LOCUS       NZ_CP048882            23255 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces bathyalis strain ASO4wet chromosome, complete genome.
ACCESSION   NZ_CP048882
VERSION     NZ_CP048882.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces bathyalis
  ORGANISM  Streptomyces bathyalis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Rohde,M., Schumann,P., Hahnke,R.L.,
            Sproer,C., Bunk,B., Kampfer,P., Schupp,P.J. and Wink,J.
  TITLE     Streptomyces bathyalis sp. nov., an actinobacterium isolated from
            the sponge in a deep sea
  JOURNAL   Antonie Van Leeuwenhoek 114 (4), 425-435 (2021)
   PUBMED   33595745
REFERENCE   2  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Schupp,P. and Wink,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2020) Microbial Strain Collection, Helmholtz
            Centre for Infection Research, Inhoffenstrasse 7, Braunschweig,
            Niedersachsen 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-FEB-2019
            Assembly Method                   :: HGAP v. v3
            Assembly Name :: Streptomyces_DSM106605_HGAP3_1SC_10M
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 117.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015910445.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 04:35:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,467
            CDSs (total)                      :: 6,387
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 37 of 111
            Pseudo Genes (incomplete)         :: 90 of 111
            Pseudo Genes (internal stop)      :: 12 of 111
            Pseudo Genes (multiple problems)  :: 25 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3614733
            Orig. end                         :: 3637988
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048882.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MISG, Helmholtz Centre for
            Infection Research, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23255
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="12"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23255
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23255
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13255](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13255
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(195..1124)
                     /gene="pheA"
                     /locus_tag="G4Z16_RS15735"
                     /old_locus_tag="G4Z16_15700"
     CDS             complement(195..1124)
                     /EC_number="4.2.1.51"
                     /GO_function="GO:0004664 - prephenate dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009094 - L-phenylalanine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="pheA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019432249.1"
                     /locus_tag="G4Z16_RS15735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15700"
                     /product="prephenate dehydratase"
                     /protein_id="WP_197351406.1"
                     /transl_table=11
                     /translation="MSSASRYTYLGPEGTFTEAALHTLPEAATRELTPMVSVPVALDAV
                     RNGEAAAAFVPIENSVEGGVTATLDELASGRPLMIYREVLLPIAFALLARPGTPLESIK
                     TVTGHPVAQPQVRRWMAEHIPDALWESAASNADGARLVQEGRYDAAFAGEFAAATYGLE
                     PLVTGIHDADNAATRFVLVGRPARPAAATGSDKTSVVFWLRDDHPGALLEVLQEFASRG
                     VNMMRIESRPTGEGIGRYCFSVDCEGHLQDRRVGDVLMGLKRACEQVRYLGSYPRADGG
                     HASERPGTTDAEFVEAADWLTRCLDGRG"
     gene            complement(1318..2040)
                     /locus_tag="G4Z16_RS15740"
                     /old_locus_tag="G4Z16_15705"
     CDS             complement(1318..2040)
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032865.1"
                     /locus_tag="G4Z16_RS15740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15705"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_197351407.1"
                     /transl_table=11
                     /translation="MYNKTVARLTYRGLLGRRRALLLCALPLLLLVVALAVRMLGDVDD
                     DVTKQLLGGFAMATIVPLIGVVAGTGAIGPEIDDGSVVYLLAKPIRRSSIIVTKLVVAI
                     GVTVAFSAVPTFVAGYILNGNSQQIATAYAVSAAAASVAYSALFLLLGTVSRHAVVFGL
                     VYALIWETLFGSLVPGARELSVQQWALTLAQKVGGSGAGITSEVGMATGVTLLAVATVG
                     GAWYAARRLRVFTLAGEE"
     misc_feature    complement(2024..2042)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            complement(2055..2972)
                     /locus_tag="G4Z16_RS15745"
                     /old_locus_tag="G4Z16_15710"
     CDS             complement(2055..2972)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609904.1"
                     /locus_tag="G4Z16_RS15745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15710"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_197351408.1"
                     /transl_table=11
                     /translation="MTTLHIDHTSRWFGNVVAVNDITMDIGPGVTGLLGPNGAGKSTLI
                     NMMGGFLPPSTGSVTLDGAPIWRNQAAYKEIGLVPEREGMYDFLTGWDFVLANAELHKL
                     SDPAAATRKALATVEMEQAQDRKISTYSKGMRQRVKMASALVHDPSVLLLDEPFNGMDP
                     RQRMQLMQLLRQMGDSGRTVLFSSHILEEVEQLASHIEVVVAGRHAASGDFRKIRRLMT
                     DRPHRYLVRSSDDRRLAAALIADASTAGIELDWNEKALQIQAIDFGRFTQVLPRLAREH
                     GIRLYTVSPSDESLESVFSYLVAA"
     gene            complement(2969..3907)
                     /locus_tag="G4Z16_RS15750"
                     /old_locus_tag="G4Z16_15715"
     CDS             complement(2969..3907)
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482881.1"
                     /locus_tag="G4Z16_RS15750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15715"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_197351409.1"
                     /transl_table=11
                     /translation="MSPEPHGSTPVATAGKPPGQRGEDVIHNIGYRNYDGPRLGRGYAR
                     TSLFGQSLRGAYGLGRSARSKVLPMILFAVMCVPAAIVVAVTVFTKAKEMPIDYNAYVI
                     QMQPVIGVYIAAMAPQAVSLDLRFRVVPLYFSRPIQRGDYVGAKYAALSAAIFVFTATS
                     VLILYVGAMLAKLDFGDETKGFAYGLVCCAVFSVLHAGIALTVAAATPRRGFGVAAIIA
                     VLTIPYMLVNVLQGILASQDNTDSIGWIGLASPGSLVDGLQSKFLDGKHAFPGGPPDLT
                     SAQASVYALLTVVLIAGTYALLLRRYRKAGL"
     gene            complement(3897..4937)
                     /locus_tag="G4Z16_RS15755"
                     /old_locus_tag="G4Z16_15720"
     CDS             complement(3897..4937)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061909.1"
                     /locus_tag="G4Z16_RS15755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15720"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_197354631.1"
                     /transl_table=11
                     /translation="MIAIESLTKRYPRVTALDRLTVGITPGVTGLVGANGAGKSTLIKI
                     LLGLSPATQGGATVLGLDVAREGAAIRERVGYMPEHDCLPPDVSATEFVVHMARMSGLP
                     FTAARERTADTLRHVGLYEERYRPMGGYSTGMKQRVKLAQALVHDPKLVLLDEPTNGLD
                     PVGRDEMLALIRRVHTDFGISVLVTSHLLGELERTCDHVVVIDGGKLLRASSTADFTKS
                     TASLAVEVTDTDSHPDGAEALRSALAAAGLSAQLPGTAGAPGAGHVLMVDATDESAYDT
                     VRDTVMELGLGLVRMEQRRHHIAEVFNTEPGAGASAPSADALTKGGGPASDRELQPQKG
                     GSGDVA"
     misc_feature    complement(5140..5154)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.24"
                     /tool="antismash"
     misc_feature    complement(5148..5161)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            5312..7093
                     /locus_tag="G4Z16_RS15760"
                     /old_locus_tag="G4Z16_15725"
     CDS             5312..7093
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (29-278). E-value:
                     1.4e-23. Score: 75.7. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS15760_Abhydrolase_1.1"
                     /NRPS_PKS="Domain: PKS_KR (326-443). E-value: 1e-10. Score:
                     33.8. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS15760_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985679.1"
                     /locus_tag="G4Z16_RS15760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15725"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_197354633.1"
                     /sec_met_domain="PF00561 (E-value: 2.1e-17, bitscore: 62.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.6e-14, bitscore:
                     51.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.2e-31, bitscore:
                     108.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIEGARERRVRTPEGVELCVAELGDAQAPTVVLIHGYPDSKEVW
                     SKVARRLSGRFHVVLYDVRGCGRSSAPEPLRGGFTLEKLTQDFLTVAGAVSPGRPVHVV
                     GHDWGSVQGWEFATAEETRGRVASFTSMSGPSLDHFGHWIKKRVNRPTPRRLAQAAGQG
                     VRSWYVYMLHTPVLPELAWRGPLSRAWPKLLRRAEKLPADGYPTSSLGRDAAHGAWLYR
                     DNVRFRLRHPRDDCHAHVPVQLITPTRDVFLSERLYDDVESWAPGVVRHTLDAKHWIPR
                     TRPDQLAVWISDFVDAQESGRAAGPGEPVRVYEGSGPYAERFGGSLVLVTGAGSGIGRA
                     TALSFAAAGARIVAVDVDGERAARTAESAERAGSPQAWAETADVSDQQQMEKLAQRIAA
                     DHGVVDVLVNNAGIGVSGPFLDTSVEDWKRTLDVNLWGVIHGCRLFGKQMAERGQGGHI
                     VNVASDAAYQPTRLLPAYGTSKAAVLMLSECLRAELAGRGIGVTAVCPGPVNTDITRTA
                     RFVGLDEAGQRRRRERVTRLYKLRNYPPEKVARVIMRAVVRNQAVVPVTPEARGVRVLS
                     RLSPRVLRAIARIEPPL"
     aSDomain        5399..6145
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS15760_Abhydrolase_1.1"
                     /evalue="1.40E-23"
                     /label="G4Z16_RS15760_Abhydrolase_1.1"
                     /locus_tag="G4Z16_RS15760"
                     /protein_end="278"
                     /protein_start="29"
                     /score="75.7"
                     /tool="antismash"
                     /translation="PTVVLIHGYPDSKEVWSKVARRLSGRFHVVLYDVRGCGRSSAPEP
                     LRGGFTLEKLTQDFLTVAGAVSPGRPVHVVGHDWGSVQGWEFATAEETRGRVASFTSMS
                     GPSLDHFGHWIKKRVNRPTPRRLAQAAGQGVRSWYVYMLHTPVLPELAWRGPLSRAWPK
                     LLRRAEKLPADGYPTSSLGRDAAHGAWLYRDNVRFRLRHPRDDCHAHVPVQLITPTRDV
                     FLSERLYDDVESWAPGVVRHTLDAKHW"
     aSDomain        6290..6640
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS15760_PKS_KR.1"
                     /evalue="1.00E-10"
                     /label="G4Z16_RS15760_PKS_KR.1"
                     /locus_tag="G4Z16_RS15760"
                     /protein_end="443"
                     /protein_start="326"
                     /score="33.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="LVLVTGAGSGIGRATALSFAAAGARIVAVDVDGERAARTAESAER
                     AGSPQAWAETADVSDQQQMEKLAQRIAADHGVVDVLVNNAGIGVSGPFLDTSVEDWKRT
                     LDVNLWGVIHGCR"
     CDS_motif       6296..6370
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G4Z16_RS15760_0001"
                     /evalue="3.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="G4Z16_RS15760"
                     /protein_end="353"
                     /protein_start="328"
                     /score="13.3"
                     /tool="antismash"
                     /translation="LVTGAGSGIGRATALSFAAAGARIV"
     gene            7090..8217
                     /locus_tag="G4Z16_RS15765"
                     /old_locus_tag="G4Z16_15730"
     CDS             7090..8217
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143927.1"
                     /locus_tag="G4Z16_RS15765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15730"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_246530881.1"
                     /transl_table=11
                     /translation="MTAGQDGLVEGARGEYRIEDLAGHSGATVRTIRAYQDRGLLPRPG
                     RRGRANVYDDTHLTRLRQIAALLERGYTLASIKDLLEAWDEGRGLSGVLGLVSEVEGPW
                     TDEEPERVTRAELDELFGEGSGDSDDAVAEAVELGVLVPLPERPGEYLLPSPQELAVAA
                     ELHRAGVPLLALTEHLRELRTQVEGIAARFMELTDEHIFRRCLHTRPSDEDASEAAGLV
                     RRLRPLAQQTVDAELARAMRTFASRSLREHLRRAAVSQEAETVGTEAPGQAAAPARAPV
                     ASSAPSPGPAPAPAGSVTTPPSVAPPASSTVSQSAATEPVRLPAATLAAVRELVGEEHA
                     GAFITAATEREVHSRAMDLLAAARPPASAGPPSSP"
     gene            8326..10014
                     /gene="crtI"
                     /locus_tag="G4Z16_RS15770"
                     /old_locus_tag="G4Z16_15735"
     CDS             8326..10014
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944618.1"
                     /locus_tag="G4Z16_RS15770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15735"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_197351410.1"
                     /sec_met_domain="DAO (E-value: 1.2e-19, bitscore: 69.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTLPGRSDHVVVVGAGLSGLSTALHLAGAGRSVTVVERAPGPGG
                     RAGRIEHRGYLLDTGPTVLTMPHLIEEAMAAVGESMSDHIELIALHPAYRAQFTDGTHI
                     DVHTEPEAMEAEIHRAAGAAEAAGYRRLRRWLEQIYRVQMRSFIDANFDSPLGLLTPDL
                     ARLAALGGFATWHGRISRFVRDERLRRIFSFQALYAGVPPTRALAAYAVIAYMDTVAGV
                     HFPRGGMYAVPRGMAASAQRAGVTFRYGTAVTRVERSPAGRAAAVHTAEGERIPCDALV
                     LTCDLPVTHRLLGGAPRRALPLRYAPSAVVLHAGGRRTWPQLAHHTISFGNTWHDTFRQ
                     LTRTGELMSDPSLLITSPTVTDPSLAPPGRHLHYVLAPCPNLVTGSHDWHAIAPRYRES
                     LQAVLHGRGLEGFGQDLETERLVTPADWAAQHHAAGTPFSAAHTLAQTGPFRTKNLPSG
                     WENVVLAGCGTTPGVGVPTVIVSGKLAAARITGTHTRTPAPPVPPRASTSTGPGPRSRT
                     ATRTRIRTRTGAGTGTRAGITPVPSGPPSSGPAVTTPKGEADAQR"
     gene            10001..10981
                     /locus_tag="G4Z16_RS15775"
                     /old_locus_tag="G4Z16_15740"
     CDS             10001..10981
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144573.1"
                     /locus_tag="G4Z16_RS15775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15740"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_197351411.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.3e-117,
                     bitscore: 389.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.1e-64,
                     bitscore: 217.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRGELNAADVLDPALRAAYARCRELNARDGKTYFLATRLLTPRQ
                     RPAVHALYGFARWADDIVDAPDPAISLDERGARLLRLDADLRAALRSGRSTHPVIAALA
                     DTAVRYAIDPQHFSDFMRSMRMDLTVAEYGTYEDLRDYMHGSAAVIGLQVLPVLGTVAP
                     PDEAGPHAASLGIAFQLTNFLRDVGEDLDRHRIYLPQDLLAAHGVDRELLRWCRLHRRN
                     DGRVRAAVRELAGTTREIYQHAARGVPMLYPVSRPCVETALLLYRGILDEIEATDCAVM
                     HRRTVVPRGRKARALLPALARTAALRARRTPFPERRGALPGTVLP"
     gene            10978..11970
                     /locus_tag="G4Z16_RS15780"
                     /old_locus_tag="G4Z16_15745"
     CDS             10978..11970
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524373.1"
                     /locus_tag="G4Z16_RS15780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15745"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_197351412.1"
                     /transl_table=11
                     /translation="MTRPGRRSPLRLLPASAWERQPPTWQAARPSLIADALKRAVNRPS
                     GNWYVLTSSRDVPDDRPIGRTVAGVELVVWRNSAGALRAAPGACPHLGAPLREAALCGG
                     RLVCRWHGLALDEGGMGDWHLFPAHDDGVLAWVRLDKVGGEEPTPLPVLPDRPAAAKTL
                     DAVVTQVGGCEPEDVVANRLDPWHGSWFHPYAFARLTVVEEPEPHNGDRFLIDVAYRLT
                     ARTGIPVRAAFAAPEPRTVVMHILEGEGATSAVETHATPLTPPGHPRPRTAVIEAVLAT
                     SERRGFAAARLAAPLLRPFMRRAAARLWRDDLAYAERRRQLISAGRFPG"
     gene            11990..13255
                     /locus_tag="G4Z16_RS15785"
                     /old_locus_tag="G4Z16_15750"
     CDS             11990..13255
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091568.1"
                     /locus_tag="G4Z16_RS15785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15750"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_197351413.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 1.3e-87, bitscore:
                     293.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTDADADVVVVGAGASGLSLAWRLVSGAAGAGRAAPRVLLVEP
                     PPGPLRSPERTWCFWEEGPGEFDDLLTAAWTRLSVTDGDGRTTTGACGTTYKMLRSTAY
                     TRELGARLASSAGVRRVTGTVTGIRDVPGGGETTGVDADGRPFRLLSRWVFDSRPPRRL
                     PPARTTLLQHFRGWFVQTRRACFDPSVAQLMDFRTPQPPPGGLAFVYLLPLSEDEALVE
                     YTVFSTSVASTRTYETALRRYLEDTRRLGDYTVTETEHGVIPMTDGVFRRRAGRSVFRI
                     GAAGGAVRPSTGYAFAALQRQATAVAAAYGAGRTPLPPEAHSWRHRTMDAVLLRALATG
                     RIDGGAFFTGLFRRNPLDRVLHFLEGRSTPAQEWAIGLRAPVLPMVRTLGELPFVPLRA
                     VQAERPSSGVRSAAVEHGGVQA"
     gene            13252..14838
                     /locus_tag="G4Z16_RS15790"
                     /old_locus_tag="G4Z16_15755"
     CDS             13252..14838
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557684.1"
                     /locus_tag="G4Z16_RS15790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15755"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_197351414.1"
                     /sec_met_domain="DAO (E-value: 8.3e-09, bitscore: 34.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHGHRPRPPLHIRDRRAVLWPAAAGAPHVREPAPRAAVVGGGIA
                     GLAAATALAERGVRVDLLEERPTLGGRLRGWHTRLADGSTATMSRGFHAFFRQYYNLRG
                     LLRRTVDDSGTGCGAGTLVPLPDYPLRRAGGPSDSFRRVPRTPPWSVLGFVARSPTFTL
                     SGMARMNPRAALPLLDVRVPEIYRRLDEVSAAEFLDRVRFPDEARDLAFEVFSRSFFAD
                     PRELSAAELVLMFHIYFLGSAEGLLFDVPAEPFPFALWDPLARRLGKLGVRVRTGVGVR
                     SLVPEGDGFALSLSARPDDADPEVHRYDACVLTLDSRGLQTLVADSPRIGDEHWRAGIA
                     RLRQAPPFLVSRYWLDRPVAPGRPGFLGTSGYGPLDNVSVLDRWEGEAARWARRSGGSV
                     VELHAYAVPAGRDRTAVEARTRHELSRVYPETARAGTVDVRHEWQQDCPHFPVGGYADR
                     PGVRTRHPRLVVAGDLVRTRLPVALMERAATTGFQAANALLATWGVRGHPLWSVPVAGR
                     SAALRALSRLG"
     gene            14916..16394
                     /locus_tag="G4Z16_RS15795"
                     /old_locus_tag="G4Z16_15760"
     CDS             14916..16394
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018471638.1"
                     /locus_tag="G4Z16_RS15795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15760"
                     /product="cryptochrome/photolyase family protein"
                     /protein_id="WP_197351415.1"
                     /transl_table=11
                     /translation="MADPERRWCFADQLGPHFLDGKDQPVLLIESRAVLRRRRFHRQKA
                     HLVLSALRHRAAELGERARFVQAETYGEALARVRDPLTVCGPTSHAAAEFVQKLDRVTV
                     LPSRGFVTGRDHFEEWAAGRGGKPLLMESFYRSARRATGLLMDGDEPAGGQWNLDKENR
                     EPPPAAAELPLPTPYVPDEDDIDAEVRADLDAAERRGEISFVGRDGPRQFPATRAEARR
                     ALKHFIEERLPTFGPYEDAMLAGDSSMSHSRLSAALNLGLLDPMECVRAAEKAWREGRV
                     PLRSAEGYVRQVIGWRDYVWHTYWHFGRGYARRNALRARRRLPDWFDRLDADDVRARCL
                     STVLGDVRDQGWTHHIPRLMVLGNYGLQRGWNPAELSDWFHRCFVDGYEWVMAANVIGM
                     SQYADGGSITTKPYAAGGAYIDRMSDFCHDCVYRPSARTGDDACPYTAGYWWFLARNEK
                     RLAGNWRLAPQLRNLHRITDLDEVVARERTRQRP"
     gene            complement(16440..17078)
                     /locus_tag="G4Z16_RS15800"
                     /old_locus_tag="G4Z16_15765"
     CDS             complement(16440..17078)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019762313.1"
                     /locus_tag="G4Z16_RS15800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15765"
                     /product="hypothetical protein"
                     /protein_id="WP_197351416.1"
                     /transl_table=11
                     /translation="MGLLDALLGRSKPVRPDLDQLFALPAAAVTLQAGADLVPTGLGSV
                     CFASVEGGAFKQLQRDVRQLLDADLSQGSRPDDDPRAGGIPVEFSQDEYGYTWLLARHE
                     PEETVELVNDLHAVNTLLEENGFGPQLLCSLVGFRGAEETESEGAAARSLALVYLYKRG
                     TFYPFAPQPGRKEKRDSTLELQIRGLLTDDLPVEPDLGRWFPVWGAPGL"
     gene            complement(17116..18027)
                     /gene="htpX"
                     /locus_tag="G4Z16_RS15805"
                     /old_locus_tag="G4Z16_15770"
     CDS             complement(17116..18027)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="htpX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610573.1"
                     /locus_tag="G4Z16_RS15805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15770"
                     /product="zinc metalloprotease HtpX"
                     /protein_id="WP_197351417.1"
                     /transl_table=11
                     /translation="MAAARGRYVADRGLTSRMVVTMFLIGLLYVLLVGVLIAALGNAWP
                     LIVIAVGGLFIAQFWFSDRIAAFSMGAREVTPEQAPELHGAVDRLCALADVPKPKVAMA
                     ESDVPNAFATGRSQRNSMVCATTGLMRRLEPQEVEGVLSHELSHVAHRDVAVMTIASFL
                     GVMAGVLTRVALFTGLSGAGRNDQSGLGIILLVIPLVSVIVYILSFLLTRLLSRYRELS
                     ADRAGALLTGRPSALASALTKVTGQMARIPTRDLRKAEPFNAFFFAPAFSGETIATLFS
                     SHPPLERRLEQLSRISAQLGQQ"
     misc_feature    18216..18234
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.02"
                     /tool="antismash"
     gene            18329..19279
                     /locus_tag="G4Z16_RS15810"
                     /old_locus_tag="G4Z16_15775"
     CDS             18329..19279
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019887792.1"
                     /locus_tag="G4Z16_RS15810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15775"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_197351418.1"
                     /transl_table=11
                     /translation="MAPPPLPPRTERVPRLSTVILPVLRWHEGGRERWQRAEELGFDTA
                     YTYDHLSWRANFRDGPWFGALPTLTAAAVATSRLRLGTLVTSPNFRHPVTLAKELMSLD
                     DISGGRVTLGIGAGGNGFDATALGQEPWTPRERADRFAEFVPLLDRLLREPVVSYEGTF
                     YSADEVRGIPGCVQRPRLPFAVAATGPRGMLLAGRYGQSWVTTGDPRIAATGTPAEGLQ
                     AVRDQIVRLGTACDQTGRDASDLEKVLLTGFVPGSPLESVDAFVDFAGKYAEAGITEIV
                     LHWPIAGSQFAADETVFERIATEGIAQLRGTAPQQ"
     misc_feature    complement(19344..19357)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.75"
                     /tool="antismash"
     gene            19468..>20289
                     /locus_tag="G4Z16_RS32530"
                     /old_locus_tag="G4Z16_15780"
                     /pseudo=""
     CDS             19468..>20289
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179: hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978943.1"
                     /locus_tag="G4Z16_RS32530"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_15780"
                     /product="HAD family hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSPAAADRAVRPRLIATDLDGTLLRDDKTVSGRTVAALAAAEAAG
                     LDVFFVTGRPARWMDVVSEHVHGHGLAICANGAAVVDLHRGGQVVDVRALDRYDALAVV
                     GALREAAPGVCFAVERSGGLHLDPEYPSLHRDPFGMVAPVEKLLGPEHEEPVLKLLAHH
                     PELDPDEFLAVGRGAAGAHAQFTRSSKSALLEISGSGVSKASTLARCCAQRGVRPEEVV
                     AFGDMPNDLEMLSWAGTAYAMANAHPDVLAATANHTSSNEADGVAEIIERLL"
ORIGIN
        1 cgctgaagag tgacccaaga gaattgctgt gacgaaaccg ccctggccgc gttggggaca
       61 cgtttgtggt ctccatgcgg ttttgtcgat attgcccgtt tcggcctccc gagttgtgca
      121 cagcccacac gagtgcctgt ggataacttt gagcgctgca ccggctgtcc cggcacagcg
      181 ccgcacagcc tcgttcagcc ccgcccgtcc agacagcgcg tcagccagtc ggccgcctcc
      241 acgaactcgg cgtcggtcgt gcccggacgc tccgaggcgt gcccgccgtc cgcccgcgga
      301 tacgagccga gatagcgcac ctgttcgcaa gcgcgcttca gacccatgag cacgtccccc
      361 acccggcggt cctgcagatg gccctcgcag tccaccgaga agcagtagcg gccgatcccc
      421 tcgccggtcg gccgcgactc gatgcgcatc atgttcacgc cgcgcgaagc gaactcctgg
      481 agcacctcca gcagcgcacc gggatggtcg tcgcgcagcc agaagacgac cgaggtcttg
      541 tccgagccgg tcgccgccgc gggccgcgcc ggacgtccca cgagaacgaa ccgggtggcc
      601 gcgttgtccg cgtcgtggat gcccgtcacc agcggttcga ggccgtacgt ggccgccgcg
      661 aactcaccgg cgaaggccgc gtcgtagcgg ccctcctgca ccagccgggc gccgtcggcg
      721 ttggacgccg cggactccca cagcgcgtcg gggatgtgct ccgccatcca gcgccggacc
      781 tgcggctgcg cgacggggtg ccccgtcacc gtcttgatgc tctccagcgg agtgcccggg
      841 cgggccagca gcgcgaaggc gatgggaagc agcacctcgc ggtagatcat caggggccgg
      901 ccgctcgcca gctcgtcgag cgtcgcggtg acgccgccct ccaccgagtt ctcgatcggg
      961 acgaaggccg ccgcggcctc gccgttgcgt acggcgtcga gggccacggg cacggacacc
     1021 atcggtgtca gttcgcgggt ggccgcttcc gggagggtgt gcagggcggc ctcggtgaag
     1081 gttccttcgg gaccgaggta cgtatagcgg ctcgctgatg acatgagccc acgttagccg
     1141 cgtcggagac gcagcgtttc cggcgtctca tctgccgggc ggcgggcccg gcgcgcgttg
     1201 acgcgaggcg cccgcgcgcc gccgtgacgg gccatgcacc gggacgacac acgtgtgggg
     1261 gccacggtcg cgtgaccgtg gcccccactc cgcgtgtgcc gccggtggcg gccgctctca
     1321 ttcctccccg gcgagcgtga agacgcgcag cctgcgggcc gcgtaccagg cgccgccgac
     1381 ggtggcgacg gccagcagcg tgacgcccgt ggccatgccc acctccgagg tgatgcccgc
     1441 cccgctgccg ccgaccttct gcgccagcgt cagggcccac tgctgtacgg acagctcccg
     1501 ggcccccggc accaggctgc cgaagagggt ctcccagatc agggcgtaga ccaggccgaa
     1561 caccacggcg tgccgcgaga ccgtgcccag cagcaggaac agtgcgctgt aggcgacgga
     1621 ggcggccgcg gcggagaccg cgtaggccgt ggcgatctgc tggctgttgc cgttgaggat
     1681 gtagcccgcc acgaacgtgg ggacggccga gaaggcgacc gtcacaccga tcgcgaccac
     1741 cagcttcgtc acgatgatgc tggagcgcct gatcggcttg gccagcaggt agaccaccga
     1801 gccgtcgtcg atctccgggc cgatggcgcc cgtaccggcg acgacaccga tgagcgggac
     1861 gatcgtggcc atcgcgaagc cgcccagcag ctgcttggtg acgtcgtcgt ccacgtcgcc
     1921 gagcatgcgc acggccaggg cgacgacgag cagcagcaac gggagcgcgc agagcagcag
     1981 ggcgcggcgg cgtcccagca atcccctgta ggtgagccgt gcgactgtct tgttgtacat
     2041 cgagagggct cccttcaggc cgcgacgagg tacgagaaga cgctctccag ggactcgtcc
     2101 gagggcgaga ccgtgtagag ccggatgccg tgctcgcggg cgagccgggg gaggacctgg
     2161 gtgaaccggc cgaagtcgat ggcctggatc tgcagcgcct tctcgttcca gtcgagctcg
     2221 atgcccgccg tggatgcgtc ggcgatgagg gccgccgcga ggcgccggtc gtcgctggag
     2281 cgtacgaggt agcggtgcgg gcggtccgtc atcaggcggc ggatcttgcg gaagtcgccg
     2341 ctggccgcgt gcctgccggc gacgacgacc tcgatgtggg acgcgagctg ctcgacctcc
     2401 tccaggatgt gcgaggagaa gagcacggtg cggcccgagt cgcccatctg ccgcagcagc
     2461 tgcatcagtt gcatgcgctg acgcgggtcc atgccgttga acggctcgtc gagcagcagc
     2521 accgacgggt cgtgcaccag ggcggaggcc atcttcacgc gctggcgcat gcccttgctg
     2581 taggtggaga tcttgcggtc ctgcgcctgt tccatctcga cggtggccag cgccttgcgg
     2641 gtggccgcgg ccgggtcgga cagcttgtgc agttcagcgt tggccaggac gaagtcccag
     2701 ccggtgagga agtcgtacat cccctcacgc tcggggacga ggccgatctc cttgtacgcc
     2761 gcctggttgc gccagatcgg tgccccgtcc agcgtgacgc ttcccgtcga gggcggcagg
     2821 aacccgccca tcatgttgat gagtgtggac ttgcccgcac cgttcgggcc gagcaggccg
     2881 gtcacgccgg ggccgatgtc catggtgatg tcgttgacgg cgacgacgtt cccgaaccag
     2941 cgggaagtgt ggtcgatatg cagagttgtc acagcccggc ctttcggtag cggcgcagca
     3001 gcagggcgta cgttccggcg atgagtacga cggtcagcag tgcgtacacg gacgcctggg
     3061 cgctcgtcag gtcgggcggg ccgcccggga aggcgtgctt gccgtccagg aacttgctct
     3121 gcaggccgtc gacgagcgac ccgggcgacg ccaggcctat ccagccgatg gagtcggtgt
     3181 tgtcctggga ggcgaggatc ccctggagca cgttgacgag catgtacgga atggtcagca
     3241 cggcgatgat ggccgcgacg ccgaagccgc ggcgcggtgt cgcggcggcc accgtcagcg
     3301 cgatgccggc atgcagtacg gagaagaccg cgcagcagac gagcccgtac gcgaagccct
     3361 tcgtctcgtc cccgaagtcg agcttcgcca gcatcgcccc gacgtagagg atgaggacgg
     3421 acgtcgccgt gaagacgaag atcgcggcgg agagcgccgc gtacttggcg ccgacgtagt
     3481 ccccgcgctg gatgggccgc gagaagtaca gcggcacgac gcggaagcgc aggtcgaggg
     3541 agacggcctg gggtgccatc gctgcgatgt agacgccgat gacgggctgc atctggatga
     3601 cgtaggcgtt gtagtcgatc ggcatctcct tggccttcgt gaagaccgtg acggcgacga
     3661 cgatcgcggc gggtacgcac atgaccgcga agaggatcat cggcagcacc ttggacctgg
     3721 ccgagcggcc cagcccgtaa gcgccgcgca gcgactgccc gaagagggag gtgcgggcgt
     3781 atccgcggcc cagccggggg ccgtcgtagt tgcggtagcc gatgttgtgg atgacgtcct
     3841 cgccgcgctg ccccggcggc ttgccggcgg tcgcgacggg tgtgctgccg tgaggctcag
     3901 gcgacatcgc cgctgcctcc cttctgcggc tggagttcgc ggtcggatgc gggaccgccg
     3961 cccttggtca gggcgtcggc ggagggggcg gaggccccgg cgccgggctc cgtgttgaag
     4021 acctccgcga tgtggtggcg gcgctgttcc atccgcacca ggccgaggcc gagttccatg
     4081 acggtgtcgc ggacggtgtc gtacgccgat tcgtcggtcg cgtcgaccat gagcacatgc
     4141 ccggcaccgg gggcgcccgc cgtgcccgga agctgcgcgg acagcccggc ggcggccagc
     4201 gcggagcgca gtgcctccgc accgtccggg tgggagtcgg tgtcggtgac ctccaccgcc
     4261 agggacgcgg tgctcttggt gaagtcggcc gtactggagg cacgcagcag cttgccgccg
     4321 tcgatgacca cgacgtggtc gcaggtgcgc tccagctcgc ccagcaggtg ggaggtgacg
     4381 agcacggaga tgccgaagtc ggtgtgtacg cggcggatca gcgcgagcat ctcgtcgcgg
     4441 ccgacggggt cgaggccgtt ggtcggctcg tcgagcagca ccagcttcgg gtcgtgcacg
     4501 agggcctgtg cgagcttgac gcgctgcttc atgcccgtcg aatagccgcc catggggcgg
     4561 tagcgctcct cgtacagacc gacgtggcgc agggtgtcgg ccgtgcgctc gcgtgcggcg
     4621 gtgaagggga gcccggacat gcgcgccatg tggacgacga actcggtcgc ggagacgtcg
     4681 ggcggcagac agtcgtgctc gggcatgtat ccgacgcgct cgcggatcgc cgcaccctcc
     4741 cgtgccacgt cgagtccgag gacggtggcg ccgccctggg tcgcggggga gagaccgagc
     4801 aagatcttga tgagggtcga ttttccggcc ccgttggcgc ccaccaggcc ggtaacaccc
     4861 ggtgtgatgc ccacggtcag ccggtccagc gcggtcaccc gtgggtaccg cttggtcagg
     4921 ctttcgatag caatcacagt caccctcctg acgctatggc ctacgagcca tgtgtcacgt
     4981 ccctctgggg ggctggatcc gactggtacc gaagggtgat gctcccttaa gggggtcgta
     5041 ggacaagtga ggcgaaaacc ctgccggtca ggcaccgcac ctcgaagtta cccctggtat
     5101 ccacagcctt gagcggtcta ttgactccgc catcgtccgt tgtcacattg atcagtgtcg
     5161 aatacgcgga cgcggcaggg gcgtcggtcc ctgccggcct cgaagggctg ggggatctgt
     5221 gagcgagcgg aacggcagcg gggccgacag cgcgggcgct gagcggggag cgggtccgcc
     5281 ccggggccgg cgccgggggg cgaccgggga cctgagtatc gagggcgcac gcgagcgccg
     5341 ggtgcgcaca ccggaaggcg tcgagttgtg cgtggcggag cttggcgacg cgcaggcccc
     5401 gaccgtcgtg ctgatccacg gctacccgga cagcaaggag gtctggtcga aggtcgcccg
     5461 gcggctcagc ggccgcttcc acgtggtcct ctacgacgta cggggctgcg gccgctcctc
     5521 ggcgcccgag ccgctgcgcg gcggcttcac cctggagaag ctgacgcagg acttcctgac
     5581 cgtggcgggc gccgtgtccc ccgggcggcc cgtgcacgtg gtggggcacg actgggggtc
     5641 cgtgcagggc tgggagttcg ccaccgcgga ggagaccagg ggccgggtcg cctcgttcac
     5701 ctcgatgtcc ggcccgtctc tcgaccactt cggccactgg atcaagaagc gggtgaaccg
     5761 tccgacgccg cggcggctgg cgcaggccgc cggccagggc gtccgctcct ggtacgtcta
     5821 catgctgcac acgccggtgc tgccggaact ggcgtggagg ggaccgctgt cacgggcctg
     5881 gccgaagctg ctgcgcaggg cggagaagct gcccgcggac ggctacccca cgtcctcgct
     5941 ggggcgcgac gccgcgcacg gcgcatggct gtaccgcgac aacgtgcgct tcaggctgcg
     6001 gcacccccgt gacgactgcc atgcccatgt gcccgtccag ctgatcaccc cgacccgcga
     6061 cgtcttcctg agcgaacggc tctacgacga cgtcgagtcg tgggcacccg gcgtcgtccg
     6121 gcacacgctg gacgccaagc actggatccc gcgcacccgg cccgaccaac tcgcggtctg
     6181 gatcagtgac ttcgtcgacg cgcaggaatc cggccgggcc gccgggccgg gcgagcccgt
     6241 gcgggtgtac gagggcagcg ggccgtacgc ggagcggttc ggcggctcgc tcgtgctggt
     6301 cacgggggcg ggaagcggca tcggccgggc cacggccctg tcgttcgccg cggccggagc
     6361 gcggatcgtg gcggtcgacg tggacggcga acgggccgcg cggaccgcgg agtcggcgga
     6421 gcgggccgga tctccgcagg cctgggcgga gacggccgac gtgagcgacc agcagcagat
     6481 ggagaagctc gcccagagga tcgctgccga ccacggggtc gtggacgttc tcgtcaacaa
     6541 cgccggcata ggcgtctccg gtcccttcct cgacaccagc gtcgaggact ggaagcggac
     6601 gctggacgtc aatctgtggg gcgtcatcca cggctgccgc ctcttcggca agcagatggc
     6661 ggaacgcggc cagggcggac acatcgtcaa cgtcgcctcg gacgcggcct atcagcccac
     6721 gcggctgctg cccgcctacg gcacgtcgaa ggccgccgtc ctgatgctga gcgagtgcct
     6781 gcgggccgag ctggcagggc ggggcatcgg cgtcaccgcg gtctgtcccg ggccggtcaa
     6841 cacggacatc accaggacgg ctcgcttcgt cggcctcgac gaggccgggc agcggcgccg
     6901 ccgggaacgg gtgacccgcc tgtacaagct gcgcaactac ccgccggaga aggtcgccag
     6961 ggtgatcatg cgggccgtcg tgcgcaatca ggcggtcgtc ccggtcaccc ccgaggcccg
     7021 cggtgtccgg gtgctctccc ggctctcacc gcgagtactg cgtgcgatcg cccggataga
     7081 gcccccgctg tgacggcggg ccaggacggc ctggtggaag gggcccgcgg tgagtaccgc
     7141 atcgaggacc tggcggggca cagcggcgcc accgtccgca cgatccgcgc ctaccaggac
     7201 cgcggcctgc tcccccggcc gggcagacgc ggaagggcca atgtctacga cgacacccat
     7261 ctgacgcggc tgaggcagat agccgcgctg ctggaacgcg gatacacgct cgcgtccatc
     7321 aaggacctgc tggaggcgtg ggacgaaggc cgcggtctga gcggtgtgct ggggctcgtc
     7381 tcggaagtcg aaggaccgtg gacggacgag gagccggagc gtgtcacccg cgccgagctg
     7441 gacgaactct tcggcgaggg ctcaggcgac agcgacgacg ccgtggccga ggcggtcgag
     7501 ctgggcgtgc tggtgccgct gccggagagg cccggggagt atctactccc cagcccgcag
     7561 gagctggccg tggccgccga actgcaccgg gcgggcgtgc cgttgctcgc gctcaccgag
     7621 cacctccgcg aactgcgcac ccaggtggag ggcatagcgg cccgcttcat ggaactcacc
     7681 gacgagcaca tcttccgccg atgcctgcac acccgtccct cggacgagga cgcctcggag
     7741 gcggcgggtc tcgtgcgccg gctgcgcccg ctggcgcagc agacggtcga cgccgaactg
     7801 gcccgcgcca tgcggacgtt cgcctcccgc agcctgcgtg agcacctgcg gcgggcggcg
     7861 gtgtcgcagg aagcggagac ggtcggaacg gaagcaccgg ggcaagctgc ggcaccggca
     7921 cgggcgccgg ttgcctcttc ggctcccagt cccggacccg cacccgcacc cgcaggctcc
     7981 gtaacgacgc ccccgtcggt ggcgccgcct gcgtcttcga cggtgtccca gtcggcggcc
     8041 accgaacccg tacggctgcc cgcggcgacc ctcgccgccg tacgggaact ggtcggtgag
     8101 gagcatgccg gcgccttcat cacggcggcc acggagcgcg aggtgcactc ccgcgccatg
     8161 gacctcctcg ctgctgcccg gcccccggcc tccgcaggac cgcccagctc tccctagtac
     8221 cggccgaagt actgaccgaa gtactgaccg acgtctgacc gaatcacccg cccacccggc
     8281 gcgccactgg cccgcgtgcg ggccaccacg ggccaccgtg gaccgatgag gacgctgccc
     8341 ggccgttccg accacgtggt cgtggtcggt gcgggcctct ccggtctttc gaccgccctg
     8401 cacctggcgg gagcggggcg aagcgtcacg gtcgtcgagc gcgccccggg ccccggcgga
     8461 cgggccgggc gcatcgagca ccgtggctat ctccttgaca ccggccccac ggtgctgacc
     8521 atgcctcacc tcatcgagga ggcgatggcg gccgtcggcg aatcgatgtc cgaccacatc
     8581 gagctgatcg cgctgcatcc cgcgtaccgc gcccagttca ccgacggtac gcacatcgac
     8641 gtgcacaccg agcccgaggc catggaggcg gagatccacc gcgcggcggg cgcagccgag
     8701 gcggcgggat accggcgact gcgacgctgg ctggagcaga tctaccgcgt gcagatgcgc
     8761 tccttcatcg acgccaactt cgactccccg ctcggactgc tcacccccga cctcgcccgg
     8821 ctggccgcgc tgggcggctt cgccacctgg cacggccgca tttcccgttt cgtccgggac
     8881 gagcggctgc ggcggatctt ctccttccag gccctctacg cgggtgtgcc gcccacccgc
     8941 gcgctcgccg cgtacgcggt gatcgcctac atggacaccg tggccggtgt gcacttccca
     9001 cgcggcggca tgtacgccgt gccccgcggc atggccgcct ccgcgcagcg ggccggcgtc
     9061 accttccgat acggcaccgc cgtgacccgc gtcgagcgct cccccgcggg ccgggccgca
     9121 gccgtacaca ccgccgaggg ggagcggatc ccctgcgacg cgctggtcct gacctgcgat
     9181 ctgcccgtca cccaccggct gctgggcggc gccccgcgac gcgcgctgcc gctgcgctac
     9241 gcgccgtcag cggtcgtgct gcacgcggga gggcgccgca cctggcccca actggcccac
     9301 cacaccatct ctttcggcaa cacctggcac gacacgttcc gccagctgac ccgcaccggt
     9361 gagctgatga gcgatccctc actgctgatc accagcccga ccgtcacgga cccctccctc
     9421 gcgccaccgg gccggcacct gcactacgta ctggccccct gccccaatct ggtgacgggc
     9481 tcgcacgact ggcatgccat cgcgccccgc taccgcgaga gccttcaggc cgtgctgcac
     9541 ggccgcggtc tggagggctt cggccaggac ctggagacgg aacggctggt gaccccggcg
     9601 gactgggccg cgcagcacca cgcggcgggg acgccgttct ccgcggccca cacgctcgcg
     9661 cagacaggcc cgttccggac caagaacctg ccttccggct gggagaacgt cgtactcgcc
     9721 ggctgcggca ccacgcccgg tgtcggtgtg ccgaccgtga tcgtctccgg gaagctcgcc
     9781 gccgcccgca tcaccggtac gcacacccgc acacctgcac cgcccgtacc cccgcgcgca
     9841 agcaccagca ccggccccgg cccccgctca cgcacggcca cccgcacccg catccgtacg
     9901 cgtacaggcg ccggcacagg cacccgcgcc ggcatcacac cggtaccgtc cggcccgccc
     9961 tcttccgggc ccgctgtcac caccccgaaa ggcgaggccg atgctcagag gtgagctgaa
    10021 cgcggcggac gtcctcgatc ccgcgctgcg cgccgcgtac gcacgctgcc gggaactcaa
    10081 cgcccgtgac ggcaagacgt acttcctcgc cacccgcctc ctgacgcccc gccagcgccc
    10141 cgcggtgcac gccctgtacg gcttcgcccg gtgggccgac gacatcgtcg acgccccgga
    10201 cccggcgatc tccctcgacg agcgcggcgc ccgcctgctg cggctcgacg ccgacctgcg
    10261 tgccgcgctg cgctccggcc gcagcacaca ccccgtcatc gcggccctcg ccgacaccgc
    10321 cgtccgctac gccatcgacc cgcagcactt cagcgacttc atgcgctcga tgcgcatgga
    10381 cctgaccgtc gccgagtacg gcacgtacga ggacctgcgc gactacatgc acggctcggc
    10441 tgccgtcatc gggctccagg tgcttccggt gctcggcacc gtcgcgcccc ctgatgaggc
    10501 cgggccgcat gccgcatcgc tcggaatcgc cttccagttg acgaacttcc tgcgcgacgt
    10561 cggagaagac ctcgaccgcc accgcatcta cctcccgcag gacctgctgg cggcgcacgg
    10621 cgtggaccgg gagctgctgc gctggtgccg tctccaccgg cgcaacgacg ggcgtgtgcg
    10681 ggcggcggtg cgcgaactcg ccggcacgac acgggagatc taccagcacg ccgcccgtgg
    10741 cgtccccatg ctgtatccgg tctcccgccc gtgcgtggag acggctctgc tcctctaccg
    10801 gggcatcctc gacgagatcg aggccaccga ctgcgccgtc atgcaccggc gcacggtcgt
    10861 cccccgcggc cgcaaggcgc gagccctgct ccccgccctc gccagaaccg ccgcgctgcg
    10921 cgcacgccgc acacccttcc ccgaacggcg tggcgcgctg cccgggacgg tgctcccttg
    10981 acgcggccgg gccggcgcag cccgctgcgg ctcctccccg cctctgcctg ggagcggcag
    11041 ccgccgacgt ggcaggcggc ccgcccctcc ctcatcgcgg acgcgctgaa gcgggccgtc
    11101 aaccgccctt ccggcaattg gtacgtgctc acctcctctc gggacgtccc cgacgaccgt
    11161 ccgatcggcc gcacggtcgc gggggtcgag ctcgtcgtct ggcggaactc ggcgggcgcc
    11221 ctgcgcgcgg cacccggcgc atgccctcat ctcggtgctc cgctgcgcga ggccgccctg
    11281 tgcggtggcc gcctcgtatg ccggtggcac ggcctggccc tggacgaagg cggcatgggc
    11341 gactggcatc tcttccccgc acacgacgac ggggtcctcg cctgggtgcg gctcgacaag
    11401 gtgggagggg aggagcccac gccgctgccg gtgctgccgg accgcccggc cgccgcgaag
    11461 accctcgacg cggtggtcac gcaggtcggc ggctgcgagc cggaggacgt cgtcgccaac
    11521 cgcctcgatc cctggcacgg ctcgtggttc cacccgtacg ccttcgcccg gctgacggtg
    11581 gtggaggagc ccgaaccgca caacggcgac cgcttcctca tcgatgtcgc ctaccggctg
    11641 acggcccgta ccggcatccc tgtgcgcgcc gccttcgccg ccccggaacc acgcaccgtc
    11701 gtgatgcaca tcctcgaagg cgagggagcc acgtccgccg tggagacgca cgccaccccg
    11761 ctgactcctc ccgggcatcc gcggccgcgc accgcggtga tcgaggccgt gctcgccacg
    11821 tccgagcgca ggggtttcgc cgctgcccgg ctcgcggcgc cgctgctgcg ccccttcatg
    11881 cgccgggccg cggcacgact ctggcgcgac gacctcgcat acgccgagcg caggcggcag
    11941 ttgatcagtg cgggacggtt cccgggttga ctgcggaaag gacgtgccga tgactgacac
    12001 cgacgcggac gccgacgtcg tcgtggtcgg agccggggca tccggcctgt ccctcgcgtg
    12061 gcgcctggtg agcggcgcgg ccggcgccgg gcgggcggcc ccccgcgtcc tgctcgtcga
    12121 gccgcccccg gggccgctcc gcagcccgga gcggacctgg tgtttctggg aagaggggcc
    12181 gggcgaattc gacgatctcc tgaccgccgc gtggacgcgg ctgtccgtca cggacgggga
    12241 cgggcgtacg accacgggcg cctgcgggac gacgtacaag atgctccgct ccacggccta
    12301 cacgcgtgaa ctgggggcgc ggctggcctc gtcggccggg gtgcgacgcg tgaccggtac
    12361 ggtcaccgga atccgcgacg tgccgggggg cggcgagacg accggggtgg acgcggacgg
    12421 acggccgttc cggctcctca gccgctgggt gttcgactcg cgcccgccac ggcggctgcc
    12481 cccggcccgc accacgctgt tgcagcactt ccgcgggtgg ttcgtgcaga ccaggcgggc
    12541 ctgcttcgac ccgtccgtgg cccagctgat ggatttccgt acgccacaac cgccgcccgg
    12601 gggcctcgcg ttcgtctacc tcctgcccct ctcggaggac gaggccctgg tcgagtacac
    12661 ggtcttctcc acctcggtgg cgagcacccg gacgtacgag accgcgctgc gccgctacct
    12721 cgaggacacc cggcggctcg gcgactacac cgtcaccgag accgagcacg gcgtcatccc
    12781 catgaccgac ggcgtcttcc ggcgccgagc cggcaggtcg gtcttccgca tcggtgccgc
    12841 ggggggcgcc gtgcggccgt cgaccggcta cgcgttcgcc gcgctccagc gccaggccac
    12901 ggccgtcgcc gccgcgtacg gggccggccg tacgccgctg ccgccggaag cgcactcgtg
    12961 gcgccaccgc accatggacg cagtcctgct gcgggctctg gcgaccggcc gcatcgacgg
    13021 cggggccttc ttcaccggcc tcttccggcg caaccccctg gaccgggtgc tgcacttcct
    13081 cgaagggcgc tcgactcccg cgcaggagtg ggcgatcggc ctgcgcgccc cggtcctccc
    13141 gatggtgcgc acgctgggcg aactcccctt cgtaccgctc cgggcagtac aggcggagcg
    13201 gccttcttcg ggcgtccggt ccgcggccgt cgagcacggg ggagtgcagg cgtgaggcac
    13261 ggccaccggc cacggccgcc gctgcacatc cgggaccggc gtgcagtcct ctggccggcg
    13321 gcggccgggg ctccgcacgt ccgcgagccc gcgccccgcg ccgccgtcgt gggcggcggc
    13381 atcgccgggc tcgccgccgc caccgccctg gccgaacgcg gcgtacgcgt cgacctcctg
    13441 gaggagcggc cgacgctggg cgggcggctg cgcgggtggc acacgcggct ggccgacggc
    13501 agcaccgcga cgatgagccg cggcttccac gccttcttcc gccagtacta caacctgcgg
    13561 ggtctgcttc ggcgtacggt cgacgactcc ggcaccggct gtggcgccgg cacgctcgtg
    13621 cccctgcccg actacccgct gcggcgcgcc ggcggcccgt ccgacagctt ccggcgggta
    13681 ccgcgcaccc cgccgtggag cgtgctggga ttcgtggcgc gcagccccac cttcacgctc
    13741 tccggcatgg cgaggatgaa cccgagggcg gcgctgcccc ttctcgacgt gcgggtgccg
    13801 gagatctacc ggcggctgga cgaggtcagc gcggcggagt tcctggacag ggtccgcttt
    13861 cccgacgagg cccgtgacct ggccttcgag gtgttctccc ggagcttctt cgccgacccg
    13921 cgcgaactgt ccgccgcgga gctcgtgttg atgttccaca tctacttcct gggatcggcg
    13981 gaaggcctgc tcttcgacgt ccccgcagag cccttcccct tcgccctgtg ggatccgctc
    14041 gcgcgccgcc tcggcaagct cggcgtcagg gtccgtaccg gcgtcggggt gcgctcgctc
    14101 gtgcccgaag gcgacggctt cgcgctgtcc ctctccgccc gcccggacga cgcggacccg
    14161 gaggtgcacc gctatgacgc ctgcgtcctg accctcgaca gcagggggtt gcagaccctc
    14221 gtcgccgact ccccccgaat cggggacgag cactggcgcg cgggcatcgc gcgcctgcgc
    14281 caggccccgc ccttcctcgt ctcgcgctac tggctggacc gacccgtggc tcccggcagg
    14341 ccgggcttcc tcggtacgag cggctacggg cccctcgaca acgtcagcgt cctcgaccgg
    14401 tgggagggcg aggccgcgcg ctgggcccgg cgaagcggcg gctcggtggt ggagctgcac
    14461 gcgtacgccg tacccgccgg ccgcgaccgc accgcggtcg aagcccgcac gcggcacgaa
    14521 ctatcccgcg tctaccccga gacggcacga gccgggaccg tcgacgtacg tcacgaatgg
    14581 cagcaggact gcccccattt ccccgtcggc ggatacgcgg acaggccggg cgtgcgcacc
    14641 cgccacccgc ggctcgtggt cgccggggac ctggtgcgca cgcggctgcc ggtcgcactg
    14701 atggagcggg cggcgaccac cgggttccag gccgcgaacg cgctgctggc cacctggggc
    14761 gttcgggggc acccgctgtg gtcggtgccg gtggcgggcc gctccgccgc gctgcgcgcg
    14821 ctgagccggc tgggctgacg gctgcgccgt cggcgccgtc ctccggccgc ccgcccgcgt
    14881 gtgcggagaa cgcgacactg ccgcagtgtg ggtgaatggc agatccagag cgccgctggt
    14941 gcttcgcgga ccagctgggc ccgcacttcc tggacgggaa ggaccagccg gtgctgctga
    15001 tcgagtcacg ggcggtgctg cgccgccgac gcttccaccg gcagaaggct catctggtgc
    15061 tctcggccct gcggcacagg gcagccgaac tgggcgagcg ggcgcggttc gtgcaggccg
    15121 aaacctacgg ggaagccctc gcccgtgtgc gggacccgtt gacggtctgc ggcccgacgt
    15181 cccatgcggc cgccgaattc gtgcagaagc tcgacagggt gacagtcctc ccctcacggg
    15241 gattcgtcac cggccgcgac cacttcgagg aatgggcggc cggtcgcggc ggcaagccgc
    15301 tgctcatgga gagcttctac cgcagcgccc gcagagcgac aggtctcctg atggacggcg
    15361 acgaacccgc cggcgggcag tggaacctcg acaaggagaa cagggagccg ccgcccgcgg
    15421 ccgccgaatt gccgctgccc acgccgtacg tcccggacga ggacgacatc gacgccgagg
    15481 tacgggccga cctcgacgcc gccgaacgca ggggcgagat ctccttcgtc ggccgcgacg
    15541 ggccccggca gttcccggcg acccgggccg aggcacggcg tgcactgaag cacttcatcg
    15601 aggagcggct gccgaccttc ggcccctacg aggacgccat gctcgccggc gactccagca
    15661 tgagccacag ccgactgtcg gcagccctga acctcggcct gctggacccc atggagtgcg
    15721 tacgcgcggc cgagaaggca tggcgggagg gcagggtgcc gctgcgcagc gcggaaggat
    15781 acgtccgcca ggtcatcgga tggcgcgact acgtgtggca cacgtactgg cacttcggac
    15841 gtggatacgc ccgccgcaac gcgctgcggg cgaggcggcg cctgccggac tggttcgacc
    15901 ggctcgacgc cgacgacgta cgggcccgct gtctgtccac cgtgctcggg gacgtgcgcg
    15961 accagggctg gacgcaccac atcccgcgtc tgatggtcct cggcaactac ggcctgcagc
    16021 ggggctggaa ccccgccgaa ctctccgact ggttccaccg ctgcttcgtc gacggctacg
    16081 aatgggtcat ggccgccaac gtgatcggca tgtcccagta cgcggacggt ggctcgatca
    16141 ccacgaagcc ctacgcggcg ggcggcgcct acatcgaccg gatgagcgac ttctgccacg
    16201 actgcgtcta ccggccgtcc gcacgcaccg gcgacgacgc gtgtccgtac accgccgggt
    16261 actggtggtt cctcgcccgc aacgagaagc gcctggccgg caactggcgc ctcgcaccgc
    16321 agctgcgcaa tctccaccgc atcaccgacc tggacgaggt ggtcgcgcgg gagcgcaccc
    16381 ggcagcgccc ctgaaccgct ccggcacgct cggcgcggac caccgcgagg cgcgcaacct
    16441 cagagtccgg gcgctcccca gacggggaac cagcggccca ggtccggttc gacgggcagg
    16501 tcgtccgtca gcagcccgcg gatctggagc tcgagcgtgc tgtcccgctt ctccttccgc
    16561 ccgggctgcg gagcgaacgg atagaaggtg ccgcgcttgt acagatagac gagggcgagc
    16621 gagcgggccg cggccccttc gctctccgtc tcctccgcgc cccggaagcc gaccagggag
    16681 cacagcagct gcggaccgaa cccgttctcc tcgagcaggg tgttcaccgc gtgcagatcg
    16741 ttgacgagct cgaccgtctc ctccggctcg tgccgggcca gcagccaggt gtagccgtac
    16801 tcgtcctggc tgaactccac cgggatcccg cccgcccggg ggtcgtcatc gggccgggac
    16861 ccctgggaga gatcggcgtc cagcaactgc cgtacgtccc gctgcagctg cttgaaggcc
    16921 ccgccctcca cgctcgcgaa gcacaccgat cccagtccgg tcggtacgag gtccgcgccc
    16981 gcctggagtg tgacggcggc cgccgggagg gcgaagagct ggtcgaggtc ggggcgcacg
    17041 ggtttgctgc ggcccagaag tgcgtcgaga aggcccacgg ggttcacgtc cctcgtactg
    17101 gtgcgaaggc ggtgctcact gctgcccgag ctgcgccgag atgcggctca gctgctccag
    17161 gcgccgctcc agcggcgggt gggaggagaa cagcgtggcg atggtctcgc cggagaaggc
    17221 gggtgcgaag aagaaggcgt tgaagggctc ggccttcctc agatcgcggg tcgggatacg
    17281 ggccatctga cccgtgacct tggtcagcgc ggaggccagg gcggagggcc gcccggtcag
    17341 gagcgcaccc gcgcggtccg cggacagttc gcggtagcgc gagagcagcc gggtcagcag
    17401 gaagctgagg atgtagacga tgacgctcac cagcgggatc accagcagga tgatgccgag
    17461 gccgctctgg tcgttgcgtc cggccccgct gagtccggtg aacagcgcga ccctggtcag
    17521 cacgccggcc atgacgccca ggaacgaggc gatggtcatg acggcgacgt cgcggtgcgc
    17581 gacgtgcgac agctcgtgcg agaggacgcc ttcgacctcc tgcggctcca ggcgccgcat
    17641 caggccagtc gtcgcgcaga ccatcgagtt gcgctggctg cgtccggtgg cgaaggcgtt
    17701 gggcacatcg ctctcggcca tggccacctt cggcttcggc acgtcggcga gcgcgcacag
    17761 cctgtccacg gcaccgtgca actcgggtgc ctgctccgga gtcacctcac gggcccccat
    17821 gctgaaggcc gcgatgcggt cgctgaacca gaactgggcg atgaagaggc cgcccaccgc
    17881 gatgacgatg agtggccacg cgttgcccag cgccgcgatc agcacgccca ccagcagcac
    17941 atagagcagc ccgatgagga acatcgtgac caccatgcgg ctggtcagtc cacggtcggc
    18001 gacatatcgc ccacgggctg ctgccatgac ggacgctcct ccctcactcc tacggaagcg
    18061 ggcccaccgg accgtctgcg tgcgccgggc tgcggcgctg cgcggcggcg cgggtccgcg
    18121 cacctccgta tcgcgtgccg taccgtcctc gtccggaagc gggccgttca cccgcgccca
    18181 gggtcgagcg gtgttccagt acgccactta tgagctaatt gtccactctt tacgttcgtt
    18241 ttggcgaatg acggagagca gccggaagct gacccggcgc agcacccggc ccgacggctc
    18301 cgaagccgcc cgccgtaggc tcggcgccat ggcacctccc cctcttcccc cgcggaccga
    18361 gcgcgtcccg agactgagca ccgtgatcct tcccgtcctg cgctggcacg agggcggacg
    18421 tgagcggtgg cagcgcgccg aagagctggg cttcgacacc gcctacacct acgaccacct
    18481 ctcatggcgg gccaacttcc gcgacggacc gtggttcggg gccctgccca ccctcaccgc
    18541 ggccgcggtg gcaacgtcac gtctgcgcct gggcaccctc gtcacctcgc ccaacttccg
    18601 gcaccccgtg acgctggcca aagaactgat gtccctggac gacatcagcg gcggccgcgt
    18661 caccctcggc atcggcgcgg gcggtaacgg cttcgacgcg acggcgctcg gccaggagcc
    18721 gtggacgccg cgggagcgcg cggaccggtt cgccgagttc gtgccgctgc tggaccggct
    18781 gctccgcgaa cccgtcgtct cctacgaggg caccttctac tcggcggacg aggtgcgcgg
    18841 gatccccgga tgcgtgcagc gcccccgctt gcccttcgcc gtggccgcca ccggcccgcg
    18901 cggcatgctg ctcgccgggc gctacgggca gtcctgggtg accacgggtg atccgcgcat
    18961 cgccgcgacg ggcacccccg ccgagggtct ccaggccgtg cgcgaccaga tcgtccggct
    19021 cggcacggcc tgcgaccaga cgggacggga cgcgtcggac ctggagaagg tcctgctcac
    19081 ggggtttgtg ccgggttcgc ccctggagtc cgtcgacgcc ttcgtcgatt tcgcggggaa
    19141 gtacgcggag gcgggaatca ccgagatcgt tctgcactgg ccgatcgccg gctcgcagtt
    19201 cgccgccgac gagacggtct tcgagcgcat cgccaccgag gggatcgcgc agctcagggg
    19261 aacggcacca cagcagtaga agcgacgtcc gggagggcac atgccccgtt cgccgctcat
    19321 caggggcacc ctccgcactg gtgtgcgtgc atatgcggaa agatggtcgc tgtgactgag
    19381 ccgcccgcat tccgcgaacc cagcgctccc cccgccgatc cggcagtcga ctcccctcag
    19441 gcccggcacg ccgccgcccc ggcggtcgtg tctccggccg ccgccgaccg ggccgtgcgc
    19501 ccccgcctga tcgccacaga cctcgacggc acgctgctgc gtgacgacaa gacggtctcc
    19561 ggacgtacgg tcgccgccct cgccgccgcg gaggccgcgg ggctcgacgt cttcttcgtg
    19621 accggccgcc ccgcccgctg gatggacgtc gtcagcgaac acgtgcacgg ccacggcctc
    19681 gccatctgcg cgaacggcgc cgctgtggtc gacctgcacc gcggaggcca ggtcgtggac
    19741 gtccgggcgc tggaccggta cgacgcgctg gccgtcgtcg gcgcactgcg cgaggcggct
    19801 cccggcgtgt gcttcgccgt cgaacgcagc ggcggactcc acctcgaccc ggagtacccg
    19861 tcgctgcacc gcgacccgtt cgggatggtc gcgcccgtgg agaagctgct gggcccggag
    19921 cacgaggagc ccgtgctgaa actgctggcc caccacccgg agctggaccc ggacgagttt
    19981 ctcgccgtgg gacgcggggc ggccggcgcg cacgcgcagt tcacccgctc cagcaagtcc
    20041 gcactgctcg agatcagcgg ctccggcgtg agcaaggcca gcacgctggc gcggtgctgc
    20101 gcgcagcggg gcgtcaggcc ggaggaggtc gtcgcgttcg gtgacatgcc gaacgacctg
    20161 gagatgctga gctgggcagg caccgcgtac gcgatggcca acgcgcatcc cgacgtgctc
    20221 gccgcgaccg cgaaccacac gtcgtccaac gaggccgacg gtgtcgccga gatcatcgag
    20281 aggctgctgc tccggtacgg gcggcggcgg cacgacgccg ctccgacagg ggcgcggggc
    20341 ggtccggacg ggcacggtgc gccggtacgt cgctcgccgc ttcacgggca agcatccggc
    20401 tgaacggccc gccggctgcg gccagttcgg cgtacctgcc gcgttcgacg gtgcggcccg
    20461 cgtcgagcac gaccacctcg tccaccgctt ccaggccctt cagccggtgc gtgatcagga
    20521 cggtggtgcg gccctcggtg acgtccagca ggtccgccgt gagcgcgtcc gccgtgggca
    20581 gatcgaggtg ttcggcgggc tcgtccagta cgaggacggg gaagtccgcg agcaacgcac
    20641 gggccagcgc gagccgttga cgctccccgc cggagaggcg ggcgccgtgc tccccgacga
    20701 gcgtgtccag gccctcgggc agcatgcccg tccaggtgtc gaggcgggcc ctcgcgagag
    20761 cggtgcgcag ctcgtcgtcc gtcgcgtcct tgcgcgcgag aagcaggttc tcgcgcagcg
    20821 agctgtcgaa gacatgggcg tcctgcgcgc acaggcccac gaagcaccgc acggtgtccg
    20881 agtgcagcgc gttcgccggt acgccgcctt cggcgggtgc accgccgagc gtgtacgaac
    20941 cgctctccgc gtcgaggaag cgcagcagcg tacgggccag cgtcgtcttg ccggagcccg
    21001 acgcaccgac gacggcgact cggtggccgg gggtgagctc caggtcgaag tccgcgaggg
    21061 gcggaggcag ttgccgcttt ccggcgtccg ggcggtgagt gccctgctgc tcagagtgct
    21121 ccaagtcctc cgtctccggg tagcgcgccg tgaccgagcg caggacgagc gggaacggtg
    21181 attcgggtgc gggcagcggg tgttcgggtt cccgcaccgg ttccggcgcg tccacgacgt
    21241 cccgcacacg ccgggccgag cgtgcggcgc gctgacggtg actgacggcg agcggcatgc
    21301 cgttgaccgc ctcgaacgcc gcgagcggcg tgagcacgac ggcggcgagc cacaccccgt
    21361 cgagacgccc cgcgtgcacc gccgccgctc cggcccacgc agcggcggtg acggtaagac
    21421 cgcacgcgag cgttgccaga ccggagccga gcgccgtcgc cgcggaggaa cgggcggcga
    21481 tccgggtgag acgccggtcc gcggcgcggg ccgcggcctt gcgtgcgggc agtgctcccg
    21541 cgacggtcaa ctcccctgtg ccggtgagga gatcgaccac ttgggtcgtc aacgcggccc
    21601 gcgagggggc gagtctgcgc tccgcgcgac gtgagagcgc gccgctgaga cccgggacgg
    21661 cgacaccggc caccagcagt ccggcggcga gcgccgcacc cgcggcgggc agaagcgcgc
    21721 cggtgaacgc gatcgccgcg cctcccgtga ccgccgcgac gacggcgggc agcagccagc
    21781 gcaggaagcg gtcctgaagg gcgtcgacgt cgctcacgag gcgggtgagc aggtctccgc
    21841 ggtgcatgaa gcggaggccg gccggggcga gcggttcgag cctgcggtag atgcggacgc
    21901 gtacgccggc gagcacgcgc agcaccgcgt cgtgcgagac gagccgctcg gcgtagcgga
    21961 acacggcgcg gccgatcccg aaggtgcgtg tcgcggtgac ggcgaccatc agatacagca
    22021 cgggcggctg ctgcgaggcg cgggagatca gccagcccga ggtcgccatg aggccgacgg
    22081 cgcagagcag ggcgagcgaa ccgaggacgg ccgcgaccgc cagccgggga ccgggaccac
    22141 ggtcgcgggg aggccgctcg ggccctggat cgtcgtccgt ccccgcacca cggttctcat
    22201 ggggcgcatc cgccggctcg tccccctgca cgtccgccca tccgtcctcc gcgtcaacgg
    22261 accgcgtacg caggtgagtt gcgcccgccg ccgtggcagt cggcaccggg gcggtcaggg
    22321 atgcggcggg caccggcggt gcgagggtga cgacgcggtc cgccgcgccc agcagtgccg
    22381 ggcggtgcgt gacgagcagt accgtgcggt cctccgagag gcgtcgcagc gtctcggcga
    22441 ccgacgattc cgtctctccg tcgagggccg ccgtgggctc gtcgagcagc aggagcggcc
    22501 ggtcggtgag gaacgcccgt gccagggcga cgcgttggcg ctgcccggcg gagattccgg
    22561 cgcccgcctc gccgagaggc gtggccgggt cgaggcccgc tcctgcggcg gtcagcgcgg
    22621 cggcgacctg cgcatcgccg gccgcgggct ctgccagccg gacgttgtcc gcgaccgtgc
    22681 ccgcgaagag gtgcgggtgc tgggggaccc aggcgatctg ggcgtgccag ccgccgggtt
    22741 cgaggtcgcg gacgtcggtg ccgtcgacac gcacggcacc cgatgcgggc cgtgcgaagc
    22801 ccagcaccgc ctggagcagc gtcgacttgc ccgcgccgga gggccccgtc agagcgaccg
    22861 tctcaccggg ccgcagggtg aggtccgtcg ggggcagcga gtcgtgggcg cgaccctcgt
    22921 ggcgcacgcg gagcccctcg acggtgaggg tggccgtccg caggtcgggg gccggggcgc
    22981 cggaaccgtt cgggagcggt tcggcgagga ctgcgaagac ctcgtccgcg gcggacagcc
    23041 cttcggcggc cgcgtggtag tgggtgccga cctggcgcag cggcagatag gcctccggcg
    23101 cgagtacgag gacgagcagg cccgtgtaca ggtcgagttc gccgtgcacc agccgcatcc
    23161 cgatgcccac cgccaccagc gccaccgaga tcgtggcgag gagttccagg accagggagg
    23221 agaggaaggc gatgcgcagg gtgcgcaggg tggcg
//
