LOCUS       NZ_CP048882            21104 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces bathyalis strain ASO4wet chromosome, complete genome.
ACCESSION   NZ_CP048882
VERSION     NZ_CP048882.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces bathyalis
  ORGANISM  Streptomyces bathyalis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Rohde,M., Schumann,P., Hahnke,R.L.,
            Sproer,C., Bunk,B., Kampfer,P., Schupp,P.J. and Wink,J.
  TITLE     Streptomyces bathyalis sp. nov., an actinobacterium isolated from
            the sponge in a deep sea
  JOURNAL   Antonie Van Leeuwenhoek 114 (4), 425-435 (2021)
   PUBMED   33595745
REFERENCE   2  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Schupp,P. and Wink,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2020) Microbial Strain Collection, Helmholtz
            Centre for Infection Research, Inhoffenstrasse 7, Braunschweig,
            Niedersachsen 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-FEB-2019
            Assembly Method                   :: HGAP v. v3
            Assembly Name :: Streptomyces_DSM106605_HGAP3_1SC_10M
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 117.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015910445.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 04:35:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,467
            CDSs (total)                      :: 6,387
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 37 of 111
            Pseudo Genes (incomplete)         :: 90 of 111
            Pseudo Genes (internal stop)      :: 12 of 111
            Pseudo Genes (multiple problems)  :: 25 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3320238
            Orig. end                         :: 3341342
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048882.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MISG, Helmholtz Centre for
            Infection Research, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21104
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21104
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21104
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11104](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11104
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            26..982
                     /locus_tag="G4Z16_RS14395"
                     /old_locus_tag="G4Z16_14370"
     CDS             26..982
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122364.1"
                     /locus_tag="G4Z16_RS14395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14370"
                     /product="TIGR03621 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_197351165.1"
                     /transl_table=11
                     /translation="MREFRFSQGLASSGTYGAVAAECRRAERDGYDAVYAADHLGIPAP
                     FQLLVAAARATERLRVGTLVLNAEFWNPALLAREAATADLLTGGRLELGLGAGHMKWEF
                     DEAGVPWRPIAERTEHLRAVVRELGRLFGSDGYEQQHGMRTRFGLPALRPVQRHGFGGA
                     GPPLIVGGTGDRVLDVAAEHADIVSIAGLYQRKGEPPGTLRLGSAAEADDRVRYVRERA
                     GARAESIEWHALAQAVVVTDDRREEAERLLERFGQAMSPEELLECPFVFVGTVEEMAEQ
                     VMRNRQRYGFTHYTVLGPYAEAFAPVVARVRELAVRD"
     gene            complement(1123..2436)
                     /locus_tag="G4Z16_RS14400"
                     /old_locus_tag="G4Z16_14375"
     CDS             complement(1123..2436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998964.1"
                     /locus_tag="G4Z16_RS14400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14375"
                     /product="SPFH domain-containing protein"
                     /protein_id="WP_197351166.1"
                     /transl_table=11
                     /translation="MSVTRSRRSVISEEVAPWSEIRQLLRGGETDKLIPVIIPKHTRRL
                     WWLLLIWLGLFALLTGVMFSLREPDGPSADVAAVAYDALASTAYAAGAVLLVLGMLWWW
                     RSSIAEIEQGTAGVLTRYGAVTRTLDPGRHYLWHPWSRVDFVVDTATEIPYSAPVMACP
                     TRENVPLRSIEFFLKFRINDAVLFVRTIGAGNFDLVLSQAVQDAIRQRARLVQTERAYD
                     LRGSDVADMQELLNRQLSRYGVRITGSNIPDVQLPAQYQQHLATRERVAKERTAYDQEW
                     GLTRKRRIDSLQMDIERAKKVRDARIVEVKAALNKAREDVAQLLEEQETNAQKVRFEIE
                     TRGRSGLISAENEARAQRRLAQAYRDNRAVLQYELARRRLEVGAILAGRAPQPVVVRTD
                     GNGGDTSALSTLLTAQLIPKLNGSLLPPEAARSADRED"
     gene            complement(2433..4175)
                     /locus_tag="G4Z16_RS14405"
                     /old_locus_tag="G4Z16_14380"
     CDS             complement(2433..4175)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524424.1"
                     /locus_tag="G4Z16_RS14405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14380"
                     /product="SPFH domain-containing protein"
                     /protein_id="WP_246530848.1"
                     /transl_table=11
                     /translation="MSQSVKRIAKAVAENPELREAAEGELRRRGGAVVRQRSGDGRDDG
                     GSGELRGDDGLDPADFPAAREQGGSIDTVMTQQTVPMDEAREVLNRSEQRREDGRKVHA
                     ICPMALPRGRSFVSMLPVLLLLVVGAAGSAITSSAGSSLLTHPLFGIHYWVLSLLAIGF
                     VWWRQGMVMVPDGCQALITRFGKLEDVVGPGRVILLNPWKRVSYIINTTREYPFNAPVR
                     EAPTKGGVKASIDLFIQFRISDPVEFVYTLGAVRGFEEKLSNATSETIRSLIYEQEAAE
                     IYDMVGEDTGRLLEQLNQQFRPAVELTNANITHAEPSDRGYRMDLASPEMVRVAKDAYT
                     HEYALHLRKEQDEGDLTKELASRHETLSAIMADIAQYQAQMDTAVERETNRAEATARQR
                     YVQAESEAKANAALLEAQALDIRAVTAAEAPEILQYRYQQQVLDTLEEVADHLPRLLRI
                     GGGTESDGGGVGVDFLALARELVGERGTELFSEEDMAAGRARLFEVSERIRAREAEIDA
                     LLETDRPTVPAAAGTAGPDADSVAESAGPSVPAAGKSPGEPRGASGNATGEAPAEAASE
                     EAAE"
     misc_feature    4148..4162
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    4462..4475
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.74"
                     /tool="antismash"
     misc_feature    complement(4840..4855)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.25"
                     /tool="antismash"
     gene            4975..6717
                     /locus_tag="G4Z16_RS14410"
                     /old_locus_tag="G4Z16_14385"
     CDS             4975..6717
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009721082.1"
                     /locus_tag="G4Z16_RS14410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14385"
                     /product="ATP-binding protein"
                     /protein_id="WP_246530849.1"
                     /transl_table=11
                     /translation="MVRAGSSPGEQGSGPVLVWLLPAVVTAAATGIAVPLVPASARTAV
                     TVCGLVATLAVAVVVAEVARRGRALTLMRAQHAEQLSMLQARLHQQERVTVQLAKERLP
                     EAVERLQEGEFAEDVLQSMPRAEGLSSEFQAAHQELLRSVVEAVQAEETLRDSAQRGVV
                     NIARRVQAIVHRQATDLRGMEDRHGQQPDFFADLLRLDHGTALIGRLADSIAVLGGARP
                     GRQWSKAVPVYSVLRGAMSRVLDYQRVELHSVADVAIVGPAVEPLIHALAELLDNATRY
                     SPPKARVHLTAGEVHAGIAIEIEDGGVGLSEEARKRAELRLKEAQAGIDLNDLGESPRL
                     GLAVVGRLAQAYDFQVSLPPSAYGGVRAVLVVPKKLVTTAPATGRAHGIGAGPGQEASR
                     REVPGTEAPAAAVPGNGAPSFDGAPASVASPAPGAPPAPGFAGDEAPRTAPQRMPFQDA
                     PSAAPPAGAPAAGHRMPPRPDPWLPESGPARQEDEVQDETPPVVERNANGLPQRRRRSA
                     NPNARPGGIGGRSTGTPQPPARPAPDEPAPGLWMADLQSGLSGKTDENSYADRNEDASS
                     DEGE"
     gene            6721..7125
                     /locus_tag="G4Z16_RS14415"
                     /old_locus_tag="G4Z16_14390"
     CDS             6721..7125
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009721083.1"
                     /locus_tag="G4Z16_RS14415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14390"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_246530850.1"
                     /transl_table=11
                     /translation="MERRADMDWMLKDLAETVPQTRHVIVLSSDGLCMAKHGTDTDTAD
                     RLAAIGSGLQSLSSAVAAEFPHSDGRMRMVVIEVNGGFMYLMAAGAGAHLAVLADEGVD
                     AGLVGGRMRDLVARIGEHLTSPPRDGGLAI"
     gene            7122..7475
                     /locus_tag="G4Z16_RS14420"
                     /old_locus_tag="G4Z16_14395"
     CDS             7122..7475
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944874.1"
                     /locus_tag="G4Z16_RS14420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14395"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_197351167.1"
                     /transl_table=11
                     /translation="MSQVPGWDDDIGPERLYVITGGRSDPSEQTGLDLVTLIVARQDPQ
                     VGMQPEHASILRVCSSPLSVAEISAYLGLPVSVITVLLADLLTEERVEARSPAPSLPDI
                     ELIEAVIHGLRNL"
     misc_feature    7230..7232
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7456..8076
                     /locus_tag="G4Z16_RS14425"
                     /old_locus_tag="G4Z16_14400"
     CDS             7456..8076
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467913.1"
                     /locus_tag="G4Z16_RS14425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14400"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_197351168.1"
                     /transl_table=11
                     /translation="MDSGISDTATGPRSEDRLPSSASSAVKIVIVGGFGVGKTTLVRSV
                     SEIRPLTTEETMTQASENIDDTAGVERKTATTVAMDFGRISLNDELVLYLFGTPGQQRF
                     WFLWNGLFDGALGAVVLVDTRRLEVSFDVIGRLEESAVPFVVAVNAFPEAPSYPVEDLR
                     SALDLDPRVPIIVCDARQRSSSQDVLLQLMHYLRSLALTSEAK"
     gene            8217..9623
                     /locus_tag="G4Z16_RS14430"
                     /old_locus_tag="G4Z16_14405"
     CDS             8217..9623
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985359.1"
                     /locus_tag="G4Z16_RS14430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14405"
                     /product="cytochrome P450"
                     /protein_id="WP_197354568.1"
                     /transl_table=11
                     /translation="MFDPSPAPPPGCPAHGLGPDGLRRLYGPEADADPIALYERLRSEH
                     GAVAPVLLPGDREAWLVLGHRENLEVSRTPSLFSRDSRLWRDMQEGKVPPTHPLAPLTM
                     WQPLCVFAEGEEHERLRRAVTESLARFEARGIRRYVTRFAHQLIDEFEPKGRADLVEQF
                     ADQLPLRVITQLFGMPEHHGPRLIEAAKDMIRGSETAVASNDYITEALQDLVDRKRASP
                     GHDVASKLIEHPARLTNDEVREHLRVVLVSANEPTVNLIANTLRLVLTDQRFRATLAGG
                     HMTLPDALEQVLWDEPPMTTNIGRWATGDAQLAGKTIKAGDMLLLGLAAGNADPQIRPD
                     KSTPMHGNRSHLAFSGGPHECPGQDLGRAIVDTGIDTLLTRIPDLRLAVPEEHLKWETA
                     LMSRRLVALPVEFAARRTNTTGRQGPGVPSVELPPLQPQEPASVPMPPVAPPPVHTSWW
                     TRLKRKLRGW"
     gene            10001..11104
                     /locus_tag="G4Z16_RS14435"
                     /old_locus_tag="G4Z16_14410"
     CDS             10001..11104
                     /EC_number="4.2.3.181"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982050.1"
                     /locus_tag="G4Z16_RS14435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14410"
                     /product="selina-4(15),7(11)-diene synthase"
                     /protein_id="WP_197351169.1"
                     /sec_met_domain="T1TS (E-value: 1.4e-80, bitscore: 270.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHGLIVPPVFSPIPPAIHPRHEAINERTTAWANTFSIGSPELRE
                     KLVVHDIGTFAARVLPEGREEVVSILADFIIWLFGVDDGLCEEGELGKDPAELVGELSR
                     MLRVAQNPDVPMLSENPLAAGLRDLRHRVSRYATPGQEARWVDALREYFLSVVWEASHR
                     SRETVPGLNDYTLMRLYDGATSVVLPLLEMGHGYELHPNERDSTAVRAAAEMAYFIITW
                     DNDLFSYHKESRAQQYYLNVLRVLENEQQLTPAEALSHAVAQRDRVMCLFLRVRDELAA
                     TGSPQLRQYLENLGTFIRGAQDWGISSHRYTTPDDPADLPSTFCDTPTDDSDEALDIPA
                     VAWWWDVLPERETFQPSHGEFRTSATV"
     gene            11385..12728
                     /locus_tag="G4Z16_RS14440"
                     /old_locus_tag="G4Z16_14415"
     CDS             11385..12728
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558486.1"
                     /locus_tag="G4Z16_RS14440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14415"
                     /product="cytochrome P450"
                     /protein_id="WP_246530851.1"
                     /sec_met_domain="p450 (E-value: 2.8e-83, bitscore: 278.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAALKAVPLAPNRRPLIGHALPLLRQPLDFMKSLRDTGDLVRVD
                     VGTLPIYFVTSAELTHELLVTKARNFDKGRFFIRARTLVGDALPTAPSDIHKRHRRLMQ
                     PMFHHARIAGYANVMATRANAMAESWKPGETVAVDEELAQFSVATLAETMFSAEISRPA
                     AEAVIRDVPILLKNALVRAVTPRLMDRMPIPANRRFDTAAARLRKVIDDVIAISHQQGD
                     EDNEDLLSLLMAARDADTGDTLSDREVRDELVAIMFAGTETTASTLAWTFHELATHPEV
                     EDQLLAEIESVLGDRPVTFEDVPKLEYMDRVLREISRMHSVPLLMRQATAPVELGGTEM
                     PVGTELAFSLYALHRDARLYEDPERFDPDRWLPEHGAKVPREGYIPFGAGNRKCIGDGF
                     AWTEIVITLATVLRRWRFQRVPGHTVKEVASAVAHPDSLPMTVLPREG"
     gene            12801..13802
                     /locus_tag="G4Z16_RS14445"
                     /old_locus_tag="G4Z16_14420"
     CDS             12801..13802
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075751.1"
                     /locus_tag="G4Z16_RS14445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14420"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_197351170.1"
                     /transl_table=11
                     /translation="MLLRQLEYLVALARERHFARAAAACFVSQPSLSAGIRKLERELDV
                     PIVQHGARFQGLTPEGERVLLWAHRILGDRDALQQEIAAMHGRLTGTLRLGAIPTALTV
                     TSLLTTPFCERHPEAGVRLESLSSREIMRRLAEFEIDAALTYLDDETLQGVHKLPLYEE
                     RYVLLTPEDEPVTADGDGDGYAGSPGDSDGYAGSTGDGEEVVSWSQAARLPLCLLSPRM
                     RNRRILDGLFAADGASVSPAVESDTVDGLYAHLASGRWSSVISHAWLHMFGIPAGMRVV
                     RLHGDGDSRPRVGLVFAAHEPRPAMVRALLEVAEGARVRDSLDELLSAHLGS"
     gene            complement(14111..14686)
                     /locus_tag="G4Z16_RS14450"
                     /old_locus_tag="G4Z16_14425"
     CDS             complement(14111..14686)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009302500.1"
                     /locus_tag="G4Z16_RS14450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14425"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_197351171.1"
                     /transl_table=11
                     /translation="MPMNRAHRRLCSSEKWAQGVRDRLLPWALEDVELGDEVLELGPGY
                     GANLRVLVEQVPSLTAVEIDGDTTRLLRESWGERARIIHGDASDLPLPDGGFSSVVCFT
                     MLHHVPEVPTQDKIFREAFRVLRPGGIFAGSDSQPNFRFRLLHIGDTMNTLPPKTLPGR
                     LEAAGFTDVLVDRHPESGGLRFRGRRPE"
     misc_feature    complement(14669..14685)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            complement(14823..15953)
                     /locus_tag="G4Z16_RS14455"
                     /old_locus_tag="G4Z16_14430"
     CDS             complement(14823..15953)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058096.1"
                     /locus_tag="G4Z16_RS14455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14430"
                     /product="hypothetical protein"
                     /protein_id="WP_246530852.1"
                     /transl_table=11
                     /translation="MADGTNGEPTARHGQDGSDGTRTNSSAPGGSWAPPPPPPPTPPAP
                     PTAPSGPPSRRGLLAAGAAAGIGVVTGCGTSSPSRPDDAKGGASSARDGGRSASPSRSP
                     KPRRTRKRPQLPRGGRELFPKYRLVGYCGLPGAPALGRLGDGDPGKRASEIEKTARKYA
                     GGREALPVLELLATVANPNAGPDGEYRTRTPGKTIRRFHELARKNDALLLLNIQPGRAG
                     MLDEVRALEEWLEHPDVGVALDPEWDMGPGQTPGETYGRTGGGEINDVADHLSKLVDEH
                     DLPHKPLVFHQVATSVLSDEKKLRPADGVTLIKSADGIGSPGLKRATWRQLVEDMPDGL
                     HTGFKLFYEEDAEGSRLMKPPEVLKLRPEPEYVMYE"
     gene            16112..17971
                     /locus_tag="G4Z16_RS14460"
                     /old_locus_tag="G4Z16_14435"
     CDS             16112..17971
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016473075.1"
                     /locus_tag="G4Z16_RS14460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14435"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_246530853.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 6e-41, bitscore:
                     138.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQKTDAMPEWEKRFRAPRVSLPDWAEDAPDRSLYVSNVTGTFEL
                     YAWDRVTGEHRQVTDRPNGTTDGVLTPDGEEIWWFSDTDGDEFGVWMRQPFKGGDDEPA
                     VPGLAPSFPAGLTIGRDGSAVIGRSTDEDGTTIHLCRPGQEPVEIYRHRESAGVADLSH
                     DGTLLVVEHTEHGDAMHSALRVMRPDGTTVAELDDSEGGTKELGLSALGFAPVPDDSRL
                     LIAHQRTGRWEPMIWEPLTGDTTELAIDLPGDVSADWYPDGSALLVSHSHQARSDLWRY
                     DLADRTLTRVETPPGSVSDATVRPVAQAAQGTEGPGGADGTGVSVEYLWSSAAQPPQVR
                     SVAGDVVLDPPGMTAPPSVAVEDAWVEGPGGTIHALVQKPEGEGPFPTVFDVHGGPTHH
                     DSDAFAGQPAAWIDHGFAVVRVNYRGSTGYGRAWTDALKHRVGLIELEDIAAVREWAVD
                     SGLADPSRLVLGGGSWGGYLTLLGLGTQPEAWAVGLAAVPVADYVTAYHDEMEALKSLD
                     RTLLGGSPEEVPERYEVSSPLTYVDDVRAPVFISAGVNDPRCPIRQVENYVQRLERRGA
                     PHEVYRYDAGHGSLVVEERIKQLRLEIDFALRHLPDPAPAARG"
     gene            complement(17898..18746)
                     /locus_tag="G4Z16_RS14465"
                     /old_locus_tag="G4Z16_14440"
     CDS             complement(17898..18746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061788.1"
                     /locus_tag="G4Z16_RS14465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_14440"
                     /product="SURF1 family protein"
                     /protein_id="WP_197351172.1"
                     /transl_table=11
                     /translation="MYRFLLTPRWWGINLFSVLAIPVCLFMGSWQLSRFEARVESHEEQ
                     QRTVSRAEHAKPEPLSRLLPVDAVTSGRTAEVTGRYDTSRPLLVPDRSLEGRRGFYVLS
                     LLRTHAGTGGHGKALPVVRGWLPGDADPSRVPRTPRGEVRVTGALQASETQGTPGVRAE
                     GGLPKGQLGMISAAALVNVVPYDVHDAWITVQHIPADSKLKPVPPVRPDNTGLDIKAFQ
                     NLGYTAEWFVFAGFVVFMWFRLFRRDAELAKDAALGIIPGPQEQDPEGASGQSRSPAST
                     A"
ORIGIN
        1 gcggccggcg ggtagctttc ggcgcatgcg ggagtttcgg ttttcacagg ggctcgcgag
       61 ttccgggacg tacggggccg tcgccgccga gtgccgccgg gccgaacgcg acggatacga
      121 cgcggtctac gccgccgacc acctcggcat cccggcaccg ttccagctgc tcgtcgccgc
      181 cgctcgggca accgagcgtc tgagggtggg cacgctggtc ctcaacgccg agttctggaa
      241 cccggcgttg ctggcccggg aggcggcgac cgccgacctc ctcaccggcg ggcggctcga
      301 actcggccta ggcgcagggc acatgaagtg ggagttcgac gaagcaggcg tgccgtggcg
      361 gccgatcgcc gagcggacgg agcatctgcg ggccgtcgta cgggagttgg ggcggctctt
      421 cggctcggac ggatacgagc agcagcacgg gatgcggacc aggttcggcc tcccggcgct
      481 ccgccccgtc cagcggcacg gtttcggcgg cgccgggccg ccgctcatcg tgggcggcac
      541 cggcgaccgg gtgctggacg tcgcggcgga gcacgcggac atcgtcagca tcgcgggcct
      601 ctaccagcgc aagggcgagc cgcccggaac gctgcggctg ggttccgccg ccgaggcgga
      661 tgaccgggtg cgttacgtca gggaacgagc gggtgcgcgt gccgagagca tcgaatggca
      721 cgcgctcgca caggcggtgg tggtgacgga cgacagacgt gaagaggccg agcgcctgct
      781 ggagcggttc gggcaggcga tgagccccga ggaactcctg gagtgcccct tcgtgttcgt
      841 cggcaccgtc gaggagatgg cggagcaggt gatgcggaac cggcagcggt acggcttcac
      901 gcactacacc gtcctcggcc cgtacgcgga ggcgttcgca cctgtcgtcg cccgcgtacg
      961 ggaactggcc gtccgcgact gacaccgcac ggccaagggc ccgcacaccc ttcccctacg
     1021 ccatcggcgt gcggagaccc cgaagcggcg tcggtgcggg ccccttgtgc cgtgcttcct
     1081 gccgtgctca cccctgccgc ggcgcgcggc gaggggccgt cctcagtcct cgcggtccgc
     1141 cgagcgggcc gcctccggcg gcagcaggga accgttcagc ttcgggatca gctgagccgt
     1201 gagcaacgtc gacagggcgg aggtgtcccc gccgttcccg tcggtgcgca cgaccaccgg
     1261 ctgcggtgcg cggcctgcga ggatcgcgcc cacctccagc cgcctgcggg ccagttcgta
     1321 ctgcagcacc gcacggttgt cgcggtaggc ctgggccagt cggcgctgcg cgcgggcctc
     1381 gttctcggcg gagatgaggc cgctgcggcc gcgggtctcg atctcgaagc gcaccttctg
     1441 cgcgttcgtc tcctgctcct ccaggagctg agccacgtcc tcacgcgcct tgttgagcgc
     1501 tgccttcacc tcgacgatgc gggcgtcgcg caccttcttc gcccgctcga tgtccatctg
     1561 gaggctgtcg atacggcgct tgcgcgtcag gccccattcc tggtcgtacg cggtgcgttc
     1621 cttggccacg cgctcccggg tggccaggtg ctgctggtac tgggcgggca gctggacgtc
     1681 cgggatgttg gagcccgtga tgcgcacccc gtagcgggag agctggcggt tgagcagttc
     1741 ctgcatgtcg gcgacgtcgg acccgcgcag gtcgtacgcg cgttccgtct gcaccaggcg
     1801 ggcgcgctgg cggatggcgt cctgcacggc ctgggagagc accaggtcga agttgcccgc
     1861 gccgatggtg cgcacgaaca ggacggcgtc gttgatgcgg aacttcagga agaactcgat
     1921 cgagcgcagc ggcacgttct cccgggtggg acacgccatc accggtgccg agtacgggat
     1981 ctcggtggcg gtgtcgacga cgaagtcgac ccgtgaccag gggtgccaga ggtagtgccg
     2041 ccccgggtcg agtgtgcggg tgacggctcc gtagcgggtc aggacgcccg cggtgccctg
     2101 ctcgatctcg gcgatggagg accgccacca ccacagcatc cccagcacga gcaggacggc
     2161 gccggcggca taggcggtcg aggccagcgc gtcgtaggcg acggcggcga cgtcggcaga
     2221 ggggccgtcg ggctccctca gcgagaacat cacgccggtc agcagcgcga agagcccgag
     2281 ccagatcagc agcagccacc acagcctgcg ggtgtgcttg gggatgatga cggggatcag
     2341 cttgtccgtc tcgccgccgc gcagcagttg gcggatctcg ctccagggag cgacctcttc
     2401 ggagatgacc gaccggcggc ttcttgtgac gctcattctg cggcctcctc ggacgcggcc
     2461 tcggccggtg cttccccggt cgcgtttccg gaggccccgc ggggttctcc gggtgacttc
     2521 ccggccgccg gcacggacgg tcccgcggac tccgccacgg agtcggcgtc agggcccgcg
     2581 gtgccggcgg cggcaggaac ggtcgggcgg tccgtctcca gcagggcgtc gatctctgcc
     2641 tcgcgtgcgc ggatgcgctc cgagacctcg aagaggcggg cgcgcccggc agccatgtcc
     2701 tcctcggaga acagctccgt gccgcgctcg cccaccaact cccgtgcgag cgcgaggaag
     2761 tcgaccccga cgccgccccc gtcggactcg gtgccgccgc cgatgcgcag cagccgcgga
     2821 aggtggtcgg cgacctcctc cagcgtgtcg aggacctgct gctggtagcg gtactgaagg
     2881 atctccggcg cctcggcggc ggtgaccgcg cggatgtcca gtgcctgcgc ctccaggagc
     2941 gccgcgttgg ccttcgcctc cgactcggcc tgtacatagc gctgacgggc cgtcgcctcg
     3001 gcgcggttcg tctcgcgctc cacggcggtg tccatctgcg cctggtactg ggcgatgtcg
     3061 gccatgatcg ccgagagggt ctcgtgacgg gaggccagct ccttcgtcag gtctccctcg
     3121 tcctgctcct tgcggaggtg cagcgcgtac tcgtgggtgt aggcgtcctt cgcgacacgc
     3181 accatctccg gcgacgccag gtccatgcgg tagccgcggt cggacggttc ggcgtgggtg
     3241 atattggcgt tggtcagctc cacggcggga cggaactgct ggttgagctg ctccaggagg
     3301 cggccggtgt cctcgccgac catgtcgtag atctcggcgg cctcctgctc gtagatgagg
     3361 ctccggatcg tctcgctggt ggcgttgctg agcttctcct cgaacccccg cacggcgccg
     3421 agcgtgtaga cgaactccac cgggtcgctg atgcggaact ggatgaacag gtcgatggac
     3481 gccttgacgc cgcccttggt cggggcctca cgcaccggcg cgttgaacgg gtactcgcgc
     3541 gtggtgttga tgatgtacga cacccgcttc cacgggttca gcaggatcac cctgccgggg
     3601 ccgaccacgt cctccagctt cccgaagcgc gtgatcagcg cctggcagcc gtccggcacc
     3661 atgaccatgc cctgccgcca ccacacgaag ccgatggcga gcagcgacag cacccagtag
     3721 tggatgccga agaggggatg ggtgaggagg gaactgcccg cggacgacgt gatggcgctc
     3781 ccggccgccc ccaccaccag cagaagcagt acgggcagca tgctgacgaa cgagcggccg
     3841 cggggcaggg ccatcgggca gatggcgtgg accttccggc cgtcctcacg gcgctgttcg
     3901 ctgcggttga gcacctcccg cgcctcgtcc atgggcacgg tctgctgcgt catcaccgtg
     3961 tcgatgctgc cgccctgttc gcgggcggct gggaagtcgg cggggtcgag tccgtcgtcg
     4021 ccgcgcagtt cgcccgaacc gccgtcgtca cgtccgtccc ccgaacgctg ccgcaccacc
     4081 gcgccgccgc ggcgccgtag ctcaccctcg gctgcttcgc gcagctccgg attctccgcg
     4141 accgccttgg cgatcctttt cacgctctgg ctcacgcaat tcccccattt cgcatgccgt
     4201 ccgtcggtgc tgcccggatg ccggtgccgg taccgatgcg ggagtccgcg ccggccgccg
     4261 tggcccgcag gtcgtgcgga agcccggtgc gaccgacggt ccccggactc cgcgcgaaca
     4321 caagacgaac ttgatgcgct cccccgttcg gtgaaccgca tggcaacaac gacgactcgc
     4381 aaggccacgt tccggtgcac cgtcggccaa cttacacaag cggcgccgcg ggcccgagag
     4441 ggaccgcgcg ttccgggcta cgtgactctg cgtcagtcac cgtcgtgcac acatagaaga
     4501 cgctagaact tcacacaacc tccgctactc gcaggttagt tctggcacgt accgatggac
     4561 cggacctggg gttcgaacat ccgcactgcc gtgtcgtacc caatagggcc tctcccggtc
     4621 actttccgac gagccggttc tttctggcca actcaccccc cgtcgccgca ttccgttttt
     4681 aggtgctgag ggcacctgtc cgtctgacgc acatttgtga gcctcggggg cctactgtcc
     4741 tgacctgctc agtttcggca ccgaagtgga ccctaagcgg cactcgcacg aagactctgc
     4801 gtcacaagtg atcggttccg gctatgctgc ccgaggctca gtggaccgga ccaacctcct
     4861 cgcccagccg ccgagttgag accgaatgtg cggttcgggc gatccccttc gtgcctgtcg
     4921 ctgctgcccc gcactgcctg ctcaccagct ttttcgattg atttgaggat cctgatggtt
     4981 cgtgctggat cgtcacccgg agagcaaggg tccggcccgg tactcgtctg gctgctgccc
     5041 gccgttgtga cggcggcggc cacaggcatc gcagtccccc tcgtaccggc gagcgcccgc
     5101 acggcggtca ccgtgtgcgg actcgtcgcg acgctcgccg tggccgtcgt ggtggccgaa
     5161 gtggcccgcc gcggacgcgc actgacgctg atgcgggccc agcatgccga gcagctgtcg
     5221 atgctccagg cccggctgca ccaacaggag cgcgtgacgg tgcagttggc caaggagcgg
     5281 ctgcccgagg ctgtggaacg cctccaggag ggcgagttcg ccgaggacgt gctgcagtcc
     5341 atgccgcggg ccgagggact cagcagtgaa ttccaggctg cgcaccagga gttgctgcgc
     5401 tccgtcgtcg aggccgtcca ggcggaggag accttgcgcg actccgcgca gcggggcgtg
     5461 gtgaacatcg cacgccgcgt gcaggccatc gtccaccggc aggcgaccga cctgcggggc
     5521 atggaggacc ggcacggcca gcagccggac ttcttcgccg acctgctgag gctcgaccac
     5581 ggcaccgccc tcatcggccg tctcgccgac agcatcgccg tgctcggcgg cgcccggccc
     5641 ggcaggcagt ggagcaaggc cgtcccggtg tacagcgtgc tgcgtggcgc gatgtcgcgg
     5701 gtgctggact accagcgcgt cgagctgcac tccgtcgccg acgtcgcgat cgtcggtccg
     5761 gcggtggaac cgctcatcca cgcgctcgcc gagcttctcg acaacgccac ccgctactcg
     5821 ccgccgaagg cacgtgtcca cctgaccgcg ggcgaagtgc acgccggcat cgccatcgag
     5881 atcgaggacg gcggcgtggg cctgagcgaa gaggcccgca agcgcgccga gttgaggctg
     5941 aaggaggccc aggcgggcat cgacctcaac gacctcggtg agtcgccgcg cctcggcctc
     6001 gccgtggtcg gccgcctcgc ccaggcctac gacttccagg tctcgctgcc gccttcggcg
     6061 tacggcggcg tgcgtgccgt gctcgtcgtg ccgaagaagc tggtcaccac cgcgcccgcc
     6121 acgggacgtg cccacggcat cggcgcgggc cccggccagg aggcatcccg ccgggaggtc
     6181 cccggcacgg aggctccggc cgccgcggtc ccgggcaacg gcgcaccgtc gttcgacggg
     6241 gcaccggcct ccgtcgcctc acccgccccg ggggccccgc ccgcgccggg gttcgcgggg
     6301 gacgaagcac cccgcactgc tccacagcgc atgccgttcc aggacgcgcc ttcggcggca
     6361 cccccggcgg gagcgcctgc cgccgggcac cggatgccgc cacgtcctga cccctggctt
     6421 ccggaaagcg gccccgcacg gcaggaagac gaagtgcagg acgagacacc accagtggtc
     6481 gagcgcaacg ccaacgggct gccccagcgc cgccgacgca gcgcgaaccc gaacgcgcgt
     6541 cccggaggca tcggcggccg gagcaccggg acgccgcagc ctccggcgcg gcccgcgccg
     6601 gacgaaccgg caccgggcct gtggatggca gacctgcaga gcggactgtc gggcaagacc
     6661 gacgagaact cctacgcgga ccgtaatgaa gacgcgtcgt cggatgaggg tgagtgaacg
     6721 atggaacggc gtgccgacat ggactggatg ctgaaggatc tggcggagac cgtcccccag
     6781 acccgccacg tgatcgtgct gtcctccgac ggtctgtgca tggccaagca cggcaccgac
     6841 accgacacgg ccgaccggct ggccgcgatc ggctccggcc tgcagagcct ctcctccgcc
     6901 gtggcggccg aattcccgca cagtgacggg cggatgcgca tggtcgtcat cgaagtcaac
     6961 ggcggtttca tgtacttgat ggcggcggga gccggcgcgc atctggccgt actcgcggac
     7021 gagggtgtcg acgcgggcct cgtcggcggg cgcatgaggg acctcgttgc tcgcatcggc
     7081 gagcatctga ccagtccccc gcgcgacggc ggattggcca tatgagccag gttccgggat
     7141 gggacgacga catcgggccc gagcggctct acgtgatcac cggcgggcgc agcgacccct
     7201 ccgagcagac gggcctggac ctcgtcacgt taatcgtggc gaggcaggac ccccaggtgg
     7261 ggatgcagcc cgagcacgcc tcgattctac gcgtgtgcag ctccccgctc tccgtggcgg
     7321 agatctccgc gtacctggga ctgcccgtga gcgtcatcac cgtcctgctg gcggacctgc
     7381 tgaccgagga acgggtcgag gcgcgatcgc ccgccccgtc gcttcctgac atcgaactga
     7441 ttgaggcggt gatccatgga ctccggaatc tctgacacag ccacggggcc taggagcgaa
     7501 gacagactgc cctcctccgc cagctccgcg gtgaagatcg tcatcgtcgg cggtttcggt
     7561 gtcggcaaga cgaccctcgt ccgttccgtc agcgagatcc gcccgctgac gacagaagag
     7621 acgatgacgc aggcgagcga gaacatcgac gacaccgccg gcgtcgaacg caagaccgcc
     7681 accaccgtcg ccatggactt cggacgcatc agcctcaacg acgagctggt gctctacctg
     7741 ttcgggacgc cggggcagca gcgcttctgg ttcctctgga acgggctctt cgacggtgcc
     7801 ctgggagccg tggtcctcgt cgacacgcgc cgtctcgagg tgagcttcga cgtgatcggc
     7861 cggctggagg agtccgccgt cccgttcgtc gtcgccgtca acgccttccc ggaggccccg
     7921 agttaccccg tcgaggacct gcgcagcgcc ctggacctcg acccgcgggt cccgatcatc
     7981 gtgtgcgacg cacgccagcg gtcctccagc caggacgtcc tgctgcagct gatgcactac
     8041 ctgcgctccc ttgcactgac ctcggaggcg aagtgacctc tccaccaccc gacccggacg
     8101 cccccggccg cccggacggc tccggccccg ctcccgcggc ccccggcgcc ggcacgccct
     8161 ccgcgcacac gcccggcgag cccgacgcgg gctcaccggc tgcctccggc ttcgacgtgt
     8221 tcgacccctc ccccgctccg ccgcccggct gccccgccca cggtctcggt ccggacgggc
     8281 tgcgccgtct gtacggaccc gaggcggacg ccgatcccat cgcgctgtac gagaggctgc
     8341 gcagcgagca cggggcggtg gctcccgtac tgctgccggg tgaccgggag gcgtggctgg
     8401 tgctggggca ccgggagaac ctcgaggtct cgcgcacgcc ctccctcttc tcccgcgact
     8461 cccgcctgtg gcgcgacatg caggagggca aggtcccgcc gacgcatccg ctggcgccgc
     8521 tgacgatgtg gcagccgctg tgcgtcttcg ccgagggcga ggagcacgag cggctgcgca
     8581 gggccgtcac cgagagcctc gcgcgcttcg aggcgcgcgg catccgccgg tacgtgacgc
     8641 gcttcgcaca ccagctgatc gacgagttcg agccgaaggg acgcgccgac ctggtcgagc
     8701 agttcgccga ccagctgccg ctgcgcgtga tcacacagct cttcggcatg cccgagcacc
     8761 acgggccccg gctgatcgaa gcggccaagg acatgatccg gggctcggag accgccgtgg
     8821 cgagcaacga ctacatcacc gaggcccttc aggacctggt ggaccgcaag cgtgcgtcgc
     8881 cgggacacga cgtggcgtcc aagctgatcg agcaccccgc ccggctcacg aacgacgagg
     8941 tgcgcgaaca ccttcgggtg gtgctcgtct cggcgaacga gccgacggtc aacctgatcg
     9001 cgaacaccct ccgcctcgtc ctgaccgacc agcgcttccg ggcgactctc gccggggggc
     9061 acatgacact gcccgacgcg ctggagcagg tgctctggga cgagccaccc atgacgacga
     9121 atatcggccg ctgggcgacg ggcgacgcac agctcgcggg caagacgatc aaggccggag
     9181 acatgctgtt gctcggcctc gccgccggca acgccgatcc gcagatccgg cccgacaagt
     9241 ccacgcccat gcacggcaac cgctcgcatc tcgcgttcag cgggggaccc cacgagtgcc
     9301 cgggccagga cctcggcagg gcgatcgtgg acaccgggat cgacacgctc ctcacgcgca
     9361 tcccggatct gcggctggcc gtcccggagg aacatctgaa gtgggagacc gcgctgatgt
     9421 cccggcggct ggtcgcgctc cccgtggagt tcgccgcacg ccgcaccaac accacgggac
     9481 gccagggacc gggcgtcccc tccgtcgaac ttccgccgct gcagccgcag gagccggcct
     9541 ccgtgccgat gcccccggtc gcaccgccgc ccgtccacac ctcgtggtgg acgcggctga
     9601 agcggaaact gcgggggtgg tgacgggggc gggggagacc aaccacgtcc gggatgtctg
     9661 caatgcccgg ccttattcgg ccactggcgt caactcgcct cctactggtg atagttgaac
     9721 gtgtaatggc gggtgaccag ggggaagcct tcctgtggcc ataacggatc cgcaggttcc
     9781 gcctgttttc ccgtggccga acagcccctt gatggagtgg tgatgtccat gtagcagacg
     9841 gtgacgtgcc gcccgcccgc agccgcggac gggcgctgtt tccgcaggca ggacgtgcta
     9901 ttggccggtt atacccggtg cagggggcca cggagaggtc aactgccgag aggttgagtg
     9961 gaaggcggcg ggagccgccg gattactgag gtgatcgaca gtggagcacg gcttgatcgt
    10021 gccacccgtt ttttctccca tcccacccgc gatacaccct cgccacgaag cgatcaacga
    10081 gcgaaccacg gcctgggcca acaccttctc catcggctcc ccggagctgc gggagaagct
    10141 ggtcgtccac gacatcggca ccttcgccgc ccgggtcctg cccgagggcc gcgaggaggt
    10201 cgtctcgata ctcgcggact tcatcatctg gctcttcggc gtcgacgacg gcctctgcga
    10261 ggagggcgaa ctcggcaagg accccgcgga gttggtgggt gagctgtcca ggatgctgcg
    10321 cgtcgcgcag aacccggacg tgccgatgct ctccgagaac cccctcgcgg cggggctgag
    10381 agatctgcgc caccgcgtct cgcggtacgc gaccccgggc caggaggccc gctgggtgga
    10441 cgcactgcgc gagtacttcc tctccgtcgt gtgggaggcc tcccaccgca gccgggagac
    10501 ggtgcccggc ctgaacgact acacgctgat gcgcctctac gacggcgcca cgtccgtcgt
    10561 cctgcccttg ctggagatgg ggcacgggta cgagctgcat cccaacgagc gggacagcac
    10621 ggcagttcgc gccgccgccg agatggcgta cttcatcatc acgtgggaca acgacctctt
    10681 ctcgtaccac aaggagagcc gggcccagca gtactacctc aacgtcctgc gagtgctgga
    10741 gaacgagcaa caactcaccc ccgccgaggc gttgtcccat gcggtcgccc aacgcgaccg
    10801 cgtcatgtgc ctgttcctgc gggtacggga cgaactcgcc gcgacgggga gccctcagct
    10861 gcgccaatac ctggagaacc tggggacgtt catccgcggg gcccaggact ggggcatcag
    10921 ttcgcaccgc tacacgacac cggacgaccc cgccgacctg ccctcgacgt tctgcgacac
    10981 ccccaccgac gacagcgacg aggccctcga catccctgcc gtcgcatggt ggtgggacgt
    11041 tctccccgag agggaaacgt ttcagccgtc gcatggcgaa ttccgcacct ccgcaacggt
    11101 ctgaacccgc gcggaaaccc cggcccacgc acatccgcgg ccacgcacac tgcacggacc
    11161 cgagcaccga tcatgcgctg accgacgcac cgccgtaagt ccgaagcaca ccaagcaacg
    11221 ccggccatgc cggcaccgaa gcccagcgcg cccacagagc accgaagacc cgtacgcctg
    11281 cacgcctttg acccgcaccg gccctcgtca cgtaccaccg aaatcgaata tcggctgcac
    11341 ctccaccccg gaccccccac ctcttgcccg aaggagctgc gaacgtgagt gctgcactga
    11401 aggctgtccc cctggccccg aaccgacgcc ccctgatcgg ccacgccctc cccctgctac
    11461 ggcagcccct cgacttcatg aagtcgctcc gagataccgg cgacctcgta cgggtcgacg
    11521 tcggaaccct gcccatctac ttcgtcacca gcgcggagct cacccatgag ctgctcgtca
    11581 ccaaggcgcg caacttcgac aagggccgct tcttcatacg ggcacgcacc ctcgtcggcg
    11641 acgcgctgcc caccgcaccc tcggacatcc acaagcggca ccgaaggctg atgcagccga
    11701 tgttccacca cgcccgcatc gccgggtacg cgaacgtcat ggccacccgc gcgaacgcga
    11761 tggccgagtc gtggaaaccg ggcgagaccg tcgccgtcga cgaggaactg gcccagttct
    11821 ccgtggccac gctcgccgag acgatgttct ccgcggagat cagccgtccc gccgccgagg
    11881 ccgtcatccg cgacgtcccg atcctgctga agaacgcgct cgttcgggcc gtcacgccga
    11941 ggctcatgga ccggatgccg atccccgcca accgccgctt cgacaccgcg gcggcacggc
    12001 tgcgcaaggt catcgacgac gtcatcgcga tctcccacca gcaaggggac gaggacaacg
    12061 aggacctgct gtccctgctc atggccgcgc gcgacgccga caccggggac acgctcagcg
    12121 accgcgaggt gcgcgacgaa ctcgtcgcga tcatgttcgc gggcaccgag acgacggcct
    12181 ccacgctcgc ctggaccttc cacgagctcg ccacgcaccc cgaggtcgag gaccagctgc
    12241 tggccgagat cgagtcggtg ctcggggacc gtcccgtcac cttcgaggac gtccccaagc
    12301 tcgagtacat ggaccgggtg ctgcgcgaga tctcccggat gcactcggtg ccgctgctca
    12361 tgcgccaggc caccgcaccc gtcgaactcg gcggtacgga gatgcccgtg ggcaccgagc
    12421 tcgccttcag cctctacgcg ctccaccgcg acgcgcgcct gtacgaggac cccgagcgct
    12481 tcgacccgga ccgctggctt ccggagcacg gcgcgaaggt gccgcgcgag ggctacatcc
    12541 cgttcggcgc cggcaaccgc aagtgcatcg gcgacggctt cgcctggacg gagatcgtca
    12601 tcacccttgc gaccgttctg cggcgctgga ggttccagcg ggtgccgggc cacaccgtca
    12661 aggaggtcgc ctcggcggtc gcgcaccccg acagcctccc catgaccgtg ctgcccaggg
    12721 aggggtgagc cgcggtcccg ggccgggcgg tcccgcacgg gggagtggac cgttcgccgg
    12781 gtgccgggtc atggtgaggc atgctgcttc gccagttgga atacctggtc gcgctggcca
    12841 gggaacgtca cttcgcgcgt gcggcggccg cttgcttcgt ctcgcagccg tcgctctccg
    12901 cgggcatccg caagctggaa cgtgagctgg acgtaccgat cgtccagcac ggcgcgcgtt
    12961 tccagggcct gacgcccgag ggcgaacgcg tcctgctgtg ggcccaccgc atactcggcg
    13021 accgcgacgc cctccagcag gagatcgccg cgatgcacgg acgcctcacc ggcaccctgc
    13081 ggctcggcgc catccccacg gcgctcaccg tcacctcgct gctgaccacg cccttctgcg
    13141 agcgccaccc cgaggcgggc gtacgtctgg aatcgctctc ctcgcgcgag atcatgcgcc
    13201 ggctcgcgga gttcgagatc gacgcggcac tcacctacct ggacgacgag accctgcagg
    13261 gcgtgcacaa gctgccgctg tacgaggagc gctacgtcct gctcacgccg gaggacgagc
    13321 cggtcaccgc cgacggcgac ggcgacggat atgccggctc ccccggcgac agcgacggat
    13381 atgccggctc caccggcgac ggcgaagagg tggtgagctg gtcgcaggcc gcgcggctac
    13441 cgctgtgcct gctctctcct cgcatgcgca accgccgcat cctcgacggg ctcttcgccg
    13501 cggacggcgc ctcggtctcc cccgccgtcg agtccgacac cgtcgacggc ctctacgcgc
    13561 acctcgcgtc gggacgctgg tcgagcgtga tctcccacgc gtggctgcac atgttcggca
    13621 tccccgcagg catgcgcgtt gtgcggctgc acggcgacgg cgacagcagg ccgcgcgtcg
    13681 gcctggtctt cgcggcccac gaaccgcggc ccgccatggt ccgcgcgctg ctggaagtgg
    13741 cggaaggcgc acgcgtacgg gactcgctgg acgagctgct cagcgcccac ctcgggtcat
    13801 aggcgccggc tatgcaggca tagggaggtt tgctttgacc cccgcgcggt ggacggagat
    13861 gctggtcgag cgcttgcacc cctgctccgc ggccggggag agcgcgagag ccaggcggcg
    13921 cctgaccgcg cccggtccgc cccgaccggg aggcactccc cctgggccct tggggccccg
    13981 gggggggacc cccagcctgg tggcccgaag ggccccggag agagcccggg gtccttccgt
    14041 caccgccccc gcggcgacga cttcggaaac gcgcccagct ggaagccgct gcgccggtac
    14101 gggtgcgccg tcactcggga cgccggccgc ggaagcgcag gccgccgctc tccgggtgcc
    14161 ggtcgaccag tacatcggtg aagcccgccg cctccagccg tcccggaagc gtcttcgggg
    14221 gcagcgtgtt catcgtgtcg ccgatgtgca gcagccggaa acggaagttg ggctggctgt
    14281 cgctgcccgc gaagatcccg ccgggacgca gcacacggaa ggcctcgcgg aagatcttgt
    14341 cctgcgtcgg gacctccggc acgtggtgga gcatcgtgaa gcagaccacg gatgagaagc
    14401 cgccgtccgg caacggcaga tccgaggcgt caccgtggat gatgcgggca cgctcgcccc
    14461 aactctcccg cagcagacgc gtggtgtccc cgtcgatctc cacggcggtg aggctgggga
    14521 cctgctcgac cagtacgcgg aggttggcgc cgtacccggg gccgagttcc agtacctcgt
    14581 cgcccagttc gacgtcctcg agggcccagg gcagcagacg gtcacgcacg ccctgcgccc
    14641 acttctcgga gctgcacaac cttcgatgtg ctcggttcat cggcatgagc agacgctacg
    14701 gcccgggtga ccgtcccgct acgctccgga cacgagctcg tcggcgctcc acgcctcggc
    14761 ccgcgccgcg cctcggccgc gccgcgaccg ttcccgaacc ggcgaggacg tgccgcaggc
    14821 cgctactcat acatcacgta ctccggttcc gggcgcagct tcaggacctc cggcggcttc
    14881 atcaggcggg agccctcggc gtcctcctcg tagaagagct tgaatccggt gtggagtccg
    14941 tcgggcatgt cctcgacgag ctgccgccac gtggcccgct tgagtccggg ggatcctatg
    15001 ccgtcggcgc tcttgatcaa cgtgacgccg tccgcggggc gcagcttctt ctcgtcgctg
    15061 aggacggacg tggcgacctg gtggaagacg agcggcttgt gcggcagatc gtgctcgtcg
    15121 acgagcttcg acaggtggtc ggcgacgtcg ttgatctcgc cgccgccggt gcgtccgtat
    15181 gtctcgccgg gcgtctggcc ggggcccatg tcccattcgg ggtcgagggc cactcctacg
    15241 tcggggtgtt ccagccattc ctccagtgcc ctgacctcgt cgagcatccc ggcgcgtccg
    15301 ggctggatgt tcagcagcag caacgcgtcg ttcttgcggg cgagttcgtg gaagcggcgg
    15361 atcgtcttcc cgggggtccg ggtgcggtac tcgccgtcgg ggcccgcgtt cgggttggcc
    15421 acggtggcga ggagttccag cacgggcagc gcctcgcggc ccccggcata cttgcgcgcg
    15481 gtcttctcga tctcggaggc ccgcttgccc ggatcgccgt cgccgaggcg gcccagcgcc
    15541 ggagctcccg gcagcccgca gtagccgacc agccggtact tcgggaacaa ctcccggccg
    15601 ccgcgaggca gttgaggccg cttcctggtc cgccgcggct tcggggacct tgacggcgag
    15661 gcgctgcgcc cgccgtcacg tgccgaactc gcgccgccct tcgcgtcgtc gggccgcgag
    15721 ggggaggacg tgccgcaacc cgtgaccacg ccgatcccgg cggccgctcc ggccgcgagc
    15781 agtcccctgc ggctcggcgg tccggacggt gccgtcggcg gagccggtgg cgtcggcggg
    15841 ggcggtggcg gtggcgccca acttccccct ggcgcagagc tgttggtcct ggtcccgtcg
    15901 gatccgtcct gcccgtgccg tgccgtcggc tcaccgttcg tcccgtcagc cacgtcgcct
    15961 ccgtccgccc ggtcggtgcg tcttgcgtgc gcgtacgtag gtccccgtcc cgtctgcttg
    16021 tcccgcgggc cccgccccga aacgatgttg atcccgccac gtacggcggc ccccgccctc
    16081 gcggcgtccg ctcccggcgc agaatgggca catgacgcag aagaccgatg ccatgccgga
    16141 gtgggagaag cgcttccggg caccgcgggt ctcgttgccc gactgggccg aggacgctcc
    16201 cgaccgctcg ctgtacgtct ccaacgtgac gggcaccttc gagctgtacg cgtgggaccg
    16261 ggtcaccggt gagcaccgcc aggtgaccga ccgccccaac gggacgaccg acggcgtact
    16321 gacgcccgac ggcgaggaga tctggtggtt ctccgacacc gacggtgacg agttcggggt
    16381 ctggatgcgg cagcccttca agggcggcga cgacgagccg gcggtacccg gtctcgcccc
    16441 gtccttcccc gcgggactga ccatcggacg cgacggcagt gccgtcatcg gccgctcgac
    16501 cgacgaggac ggcacgacga tccacctctg ccgtcccggc caggagcccg tcgagatcta
    16561 ccgccatcgc gagtccgccg gggtggccga cctctcgcac gacgggacgc tgctcgtcgt
    16621 cgaacacacc gagcacggcg acgcgatgca ctccgcgctg cgcgtgatgc gccccgacgg
    16681 cacgaccgtc gccgaactcg acgacagcga gggaggcacc aaggaactcg gcctgtccgc
    16741 cctcgggttc gcgcccgtgc cggacgactc ccggctgctg atcgcgcacc agcgcacggg
    16801 ccgctgggag ccgatgatct gggaacccct cactggagac acgaccgagc tcgccatcga
    16861 cctgcccggg gacgtgagcg ccgactggta tccggacggc agcgcgctcc tcgtgtccca
    16921 cagccaccag gcgcgcagcg acctgtggcg ctacgacctc gcggaccgca ccctgacccg
    16981 ggtcgagacc ccgcccggct cggtctccga cgcgacggta cggcccgtcg cgcaggccgc
    17041 gcagggaacg gaggggcccg gcggagcgga tggcaccggc gtcagcgtcg agtatctgtg
    17101 gtcgtccgcg gcacagccac cgcaggtgcg ttccgtcgcc ggtgacgtcg tcctggaccc
    17161 gcccggcatg acggcaccgc cgtcggtcgc agtcgaggac gcctgggtgg agggccccgg
    17221 cggcaccatc cacgcgctcg tgcagaagcc ggagggcgag ggccccttcc ccaccgtctt
    17281 cgacgtgcac ggcggcccga cccatcacga cagcgacgcc ttcgcgggcc agcccgccgc
    17341 gtggatcgac cacggcttcg ccgtcgtacg cgtcaactac cgcggctcca ccggctatgg
    17401 acgggcctgg acggacgcgc tcaagcaccg cgtcggcctc atcgagctgg aggacatcgc
    17461 ggcggtgcgt gagtgggccg tcgattccgg cctcgccgat cccagtcggc tggtgctggg
    17521 cggcggatcg tggggcggct atctgacgct gctcggcctg ggcacccagc ccgaggcgtg
    17581 ggcggtcggc ctcgccgccg tgccggtcgc cgactacgtc accgcgtacc acgacgagat
    17641 ggaggcgctg aagtcgctgg accgcacgct gctcggcggc tccccagagg aggtgccgga
    17701 gcgctacgag gtctcgtcac cgctgacgta cgtcgacgac gtccgcgcac cggtcttcat
    17761 ctccgcgggc gtcaacgacc cgcgctgccc catccggcag gtcgagaact acgtgcagcg
    17821 gctggagcgg cgaggggcac cgcacgaggt gtaccgctac gacgccgggc acggatcgct
    17881 cgtggtcgag gagcggatca agcagttgag gctggagatc gactttgccc tgaggcacct
    17941 tccggatcct gctcctgcgg cccggggatg atgccgagcg cggcgtcctt cgcgagctcc
    18001 gcgtcccggc ggaagagccg gaaccacatg aagaccacga agcccgcgaa gacgaaccac
    18061 tcggccgtgt agccgaggtt ctggaacgcc ttgatgtcga ggccggtgtt gtcgggacgt
    18121 acgggcggca ccggcttcag tttcgagtcg gcagggatgt gctgcacggt gatccaggcg
    18181 tcgtggacgt cgtacgggac gacgttgacg agggccgccg cgctgatcat gccgagctgc
    18241 cccttcggca ggcccccttc ggcccgcacg cccggagtgc cctgtgtctc ggacgcctgg
    18301 agcgcaccgg tcacccgcac ctccccgcgc ggagtccggg gcacccggga gggatcggcg
    18361 tcgccgggca gccatccccg caccaccggg agcgccttgc cgtggccgcc ggtcccggcg
    18421 tgggtgcgca gcagcgacag cacgtagaag ccacgcctgc cctccaggct ccggtcgggg
    18481 accagcagcg gacgggaggt gtcgtagcgt ccggtgacct ccgcggtgcg gccgctggtc
    18541 acggcgtcga cgggcagcag ccgggacagc ggttcgggct tcgcgtgctc cgcgcgggag
    18601 accgtcctct gctgctcctc atggctctcg acccgtgcct cgaagcggga gagctgccag
    18661 ctgcccatga agaggcacac cgggatcgcc agcacggaga agaggttgat tccccaccac
    18721 cgcggggtca gcaggaaccg gtacacgcct caacggtacg gggccgggga gcggcggtgg
    18781 cgcgtgggtg cgcgcggcgc gggtgcgcgc ggcgccaggc gccgggcacg cacgcggcgc
    18841 gggtacgcgc agcgtcggga tccgggcacg cacgcggcgc gggtgcattc ggcgctgggc
    18901 gacgggccgg agcgcgggtg cgcgcggtgt cgggacccgg gcacgcacgg ggcgcgggta
    18961 cgcgcagcga gcggccctgg gcgacgggcc ggagcgcggg tacgcgcagc gaggggcgcc
    19021 gggcgacggg ccggggcgcg gcacagctca tgagcgggtg cagggtatgg ccgccggaca
    19081 caggccgcgg ggcaccttcg ccgtccggct ttcccacccc ggccaaccgg tcccggaggg
    19141 cccgcgggcc cgcgggcccg cggcccggcc agtcgacccg gtcagtcggc cgcaagcact
    19201 ccggtgcggt agagcgtgcc ggcgcaggcg ccctcgagtt cggtgttcgc cgccgccgga
    19261 tcgcccacgt ccggtgtgtg gctgagcacg acgctggcct cctcgtccga ctccccgccg
    19321 tcgccgccgg agttggagct gttgccgccg gcgtcgtcgc cgccggagtt cccgttgctg
    19381 ccaccgctgt cgttgccgcc ggggttgccg ttgttgccgc cctggctgcc ctcgggcccg
    19441 ttgccctcct gggccttggg ctcgggatcg ccggagggtt cgcagtcctt gggcacccag
    19501 gcccacttga cctcgtaggc ctggccgggc ttcagcacca gctcgctcgc ggcgagggcg
    19561 gggtcgggaa gcgccgtggc ggcgtcgccc gcggtgtggt ccaggacgtc tatgcgctcg
    19621 atgtcggcac ggccgtgcgc ggacgcgccg acgatgccct cgccctcgac ggtgcaggcg
    19681 tcggaggagg tgttgacgac gcggaagctg ccgtagacct tcccctcgga gtcggggctc
    19741 tccgtcgccg ccgagccgtc gccgagctgt tgccggccgc agctcggggc gctcgtggcg
    19801 agggtgtcgt tcgggtctcc cccctcggag cccgcgccct gcgtgggcga gggcgacgcc
    19861 gatccgtcac cgccgcccga cttgccgccg ttgccgctcg caccgcccga cccgctgccc
    19921 gggccctggg tgttgccggt accgttcgcc ccgccgacgc tctgcgcctg gctgttgccc
    19981 tcgcccgcgt tgatcgacga gccgccctcg atgcccggga tcagccccgc gttcaccagc
    20041 ccggggaagc ccactcccac cagcacgacg gcggccgcgg cgcccgcgag ggcacggcgg
    20101 cggtgcgcac ggcgggccgg caccgcgtgc ttgaggtggg tgagggcctc gggggcgggc
    20161 tcgatgccgc gcacgctctg gtgcagcatc cggcgcagct ccgcctcgac ctcgctgtcg
    20221 tcgccgtcgt gaccgccgtc gccggcggga ccgtgttccc cgtcgccgcc gctgcccccg
    20281 ccgcccgttc cgcggagacc gccgccggag ccctgcccgc cgttgccgcc gggagcgggc
    20341 ggaggcacgg cggcgccttc tccccactcc tgcggggagc cgtgacgccg ctccggctgc
    20401 tccaggccgg acggacccgg ctcgtccggg aatcgcatcg tgtacgtgtg gttcgaatgc
    20461 atggctgtta ccgcgctggc tgctaccgcg tcgagaaccg cgtccggccc accgggggcg
    20521 gaatgcggag ggtcagggag gtccggcgga cgcggcacgt cgggcgcgtc cggggccgat
    20581 gggtcgccgg gcgcgcccgg caggtccgca ggggggcccg ggaggtcgac gggccggtcc
    20641 agctccggca ggtccggatc gtcgatccgc ggaggttccg ggatctcggg ctcgtcatgg
    20701 atgccggggc tctctgggat ctcgggagcc tccggaacgt cgggcatgtc ggggacatgc
    20761 ggcgccggcg gtatgtccgg cgtcggcggg atctccgggc tccgcagcac gtccggtgcg
    20821 ccggggatct ccggcatctc cgccggaccg tcgacctccg ggacgtccgg cactccgggc
    20881 agatccggca gatcggggga ctcgggtgcc tcgtgcggcg ggaattcggg gctttcgggc
    20941 acgtggggtg cgtccggcgc gtgcggcgtc tcgggcgcgt gcggcccgtc cggcagaccg
    21001 ggctcctcgg gaccggtgcc cgggccgccc tgctcgtggg cggcgaccgg cgcggcaccg
    21061 cggccgcccg ggttgtgccc gttgaggtgc atacccagct cgta
//
