LOCUS       NZ_CP048882            22003 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces bathyalis strain ASO4wet chromosome, complete genome.
ACCESSION   NZ_CP048882
VERSION     NZ_CP048882.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces bathyalis
  ORGANISM  Streptomyces bathyalis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Rohde,M., Schumann,P., Hahnke,R.L.,
            Sproer,C., Bunk,B., Kampfer,P., Schupp,P.J. and Wink,J.
  TITLE     Streptomyces bathyalis sp. nov., an actinobacterium isolated from
            the sponge in a deep sea
  JOURNAL   Antonie Van Leeuwenhoek 114 (4), 425-435 (2021)
   PUBMED   33595745
REFERENCE   2  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Schupp,P. and Wink,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2020) Microbial Strain Collection, Helmholtz
            Centre for Infection Research, Inhoffenstrasse 7, Braunschweig,
            Niedersachsen 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-FEB-2019
            Assembly Method                   :: HGAP v. v3
            Assembly Name :: Streptomyces_DSM106605_HGAP3_1SC_10M
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 117.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015910445.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 04:35:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,467
            CDSs (total)                      :: 6,387
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 37 of 111
            Pseudo Genes (incomplete)         :: 90 of 111
            Pseudo Genes (internal stop)      :: 12 of 111
            Pseudo Genes (multiple problems)  :: 25 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 505994
            Orig. end                         :: 527997
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048882.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MISG, Helmholtz Centre for
            Infection Research, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22003
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22003
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22003
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12003](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12003
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(601..1779)
                     /locus_tag="G4Z16_RS02285"
                     /old_locus_tag="G4Z16_02275"
     CDS             complement(601..1779)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827487.1"
                     /locus_tag="G4Z16_RS02285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02275"
                     /product="DUF6596 domain-containing protein"
                     /protein_id="WP_197354104.1"
                     /transl_table=11
                     /translation="MDEVLLRSLTPSVLGILVRRGADFAAAEDAVQDALVEAVRVWPAE
                     PPRDPKGWLVTVAWRRFLDATRAETARRRREDLVDEEPAPGPVPAADDTLQLYFLCAHP
                     SLTPSSAVALTLRAVGGLTTRQIAQAYLVPEATMAQRISRAKRTVSGVRFDQPGDAATV
                     LRVLYLVFNEGYSGDVDLAAEAIRLTRQLAAAFDHPEVAGLLALMLLHHARRAARTAPD
                     GSLVPLAEQDRGRWDTKLIAEGVEILQAALARDRLGEFQAQAAIAALHADAPTAEETDW
                     VQIVEWYDELTRLTDSPVVRLNRAVAVGEADGPRAGLVALAALDESAPSGSSSRGDSLP
                     RRAAVAAYLHERDGNLAKAARLYVEAAEKAPNLAEREHLTRQAARLNAQLRR"
     gene            complement(1788..2195)
                     /locus_tag="G4Z16_RS02290"
                     /old_locus_tag="G4Z16_02280"
     CDS             complement(1788..2195)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007512669.1"
                     /locus_tag="G4Z16_RS02290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02280"
                     /product="YciI family protein"
                     /protein_id="WP_197348918.1"
                     /transl_table=11
                     /translation="MSKYLLLKHYRGAPAAVNDVPMDQWKPEEISAHIQYMNDFAARLE
                     KTGEFVDGQALAPEGTWVRYDGEGRPPVTDGPFAETKDVIAGWMVIDVDTYERAVELAG
                     ELSAAPGADGKPIHEWLELRPFLTEPPTITE"
     gene            complement(2370..2594)
                     /locus_tag="G4Z16_RS02295"
                     /old_locus_tag="G4Z16_02285"
     CDS             complement(2370..2594)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS02295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_02285"
                     /product="hypothetical protein"
                     /protein_id="WP_197348919.1"
                     /transl_table=11
                     /translation="MRVPRELIHSCLDGRRCDRVALERALVAEELAVLVFLWPPYAPFN
                     RPSGIARVRRRARELQDRYFDGTAHGTVP"
     gene            2977..3855
                     /locus_tag="G4Z16_RS02300"
                     /old_locus_tag="G4Z16_02290"
     CDS             2977..3855
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AurF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998126.1"
                     /locus_tag="G4Z16_RS02300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02290"
                     /product="diiron oxygenase"
                     /protein_id="WP_197348920.1"
                     /sec_met_domain="AurF (E-value: 1.6e-33, bitscore: 114.7,
                     seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTVKPVKLDLHRLEVMAESDYYNPYTVFDWPDTLEEDRPWMSE
                     DLVTLAGTEKWDELTREQQLALTRHEAVNFFSLNVHGIRELLSEVVLRIHTRTYAEASE
                     FLHHFIGEENEHMWFFGTFCRRYLGKVYPAVPQVGVSRLEGVSEAAHELLVFARILIFE
                     EIVDYFNARMATDQALPHIAREINRVHHQDESRHVAFGRRLFTQLLTQVQENSPQDVPV
                     LAEYLEKYLQYSVQSLYNPAVYRDAGLAEPLELRRHLLAHPARHAAHDRILQRTRRFLA
                     RSGLDTQGATA"
     gene            3852..4097
                     /locus_tag="G4Z16_RS02305"
                     /old_locus_tag="G4Z16_02295"
     CDS             3852..4097
                     /NRPS_PKS="Domain: PP-binding (18-71). E-value: 9.7e-07.
                     Score: 21.0. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS02305_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1147: putative acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018486884.1"
                     /locus_tag="G4Z16_RS02305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02295"
                     /product="acyl carrier protein"
                     /protein_id="WP_197348921.1"
                     /sec_met_domain="PP-binding (E-value: 2.1e-06, bitscore:
                     26.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDKIAKILAFIHERNPEAGELGLDDDLIDRRAVDSLAFVEFLY
                     LLEELSGETIDPEELDLEDFRTLRAIDKRFLSGAVH"
     aSDomain        3906..4064
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS02305_PP-binding.1"
                     /evalue="9.70E-07"
                     /label="G4Z16_RS02305_PP-binding.1"
                     /locus_tag="G4Z16_RS02305"
                     /protein_end="71"
                     /protein_start="18"
                     /score="21.0"
                     /tool="antismash"
                     /translation="EAGELGLDDDLIDRRAVDSLAFVEFLYLLEELSGETIDPEELDLE
                     DFRTLRAI"
     gene            4097..4948
                     /locus_tag="G4Z16_RS02310"
                     /old_locus_tag="G4Z16_02300"
     CDS             4097..4948
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS02310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_02300"
                     /product="hypothetical protein"
                     /protein_id="WP_197348922.1"
                     /transl_table=11
                     /translation="MDTGTGTTVNDGLDVLGADELRLLRVLDDLFTEWGVRLGAEERRY
                     PFLLKPRELEDVDYYENFPHLGLAAATADPKLLGELRAVREAPLAELPTEVLHDAALAL
                     PSAACYSVYFHLRGQTLPSEENRVTTRATCFRNETQYEGLRRLLGFSMREIVFVGHAAG
                     ATEHLERTKELVLGFADALGLAMDTRTATDPFFDSRSSRATMQRLFPVKEEFVVDGLAV
                     GSVNYHRNFFGERCAIALPDGTPASTSCCAFGLERWVHILSTRFSGARDAAEAVARSSV
                     NA"
     gene            4991..5842
                     /locus_tag="G4Z16_RS02315"
                     /old_locus_tag="G4Z16_02305"
     CDS             4991..5842
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (45-263). E-value:
                     1.5e-20. Score: 65.8. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS02315_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="G4Z16_RS02315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02305"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_197348923.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.6e-13, bitscore:
                     49.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.3e-10, bitscore: 39.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDMTVDDVLETGTVQVSDDIRLSYERRGSGTDIVLLNNFFVDRK
                     SWRAYTGDLAAAARLTAYDLRGQGESTPLADEPVWEEHISDLKALFDGLGIEKAFLVGT
                     SFSTLLCRDFAIAHPDRVHGLVLASPALSPYGPQRLRRLTKSWLHTLDTSGLAVLHDQV
                     YPLVCSDRAVEEVGTAGFLGYKQNFLGIHTVESLRAGLLASTKAPLDPQTLTQVRQPTL
                     LFVGGDDFSLSLDATERLTKLLPDATAVIVPHGGHAAFVEESEWFNREVLAFVRRVTGT
                     DE"
     misc_feature    complement(5040..5054)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     aSDomain        5126..5779
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS02315_Abhydrolase_1.1"
                     /evalue="1.50E-20"
                     /label="G4Z16_RS02315_Abhydrolase_1.1"
                     /locus_tag="G4Z16_RS02315"
                     /protein_end="263"
                     /protein_start="45"
                     /score="65.8"
                     /tool="antismash"
                     /translation="SWRAYTGDLAAAARLTAYDLRGQGESTPLADEPVWEEHISDLKAL
                     FDGLGIEKAFLVGTSFSTLLCRDFAIAHPDRVHGLVLASPALSPYGPQRLRRLTKSWLH
                     TLDTSGLAVLHDQVYPLVCSDRAVEEVGTAGFLGYKQNFLGIHTVESLRAGLLASTKAP
                     LDPQTLTQVRQPTLLFVGGDDFSLSLDATERLTKLLPDATAVIVPHGGHAAFVEE"
     gene            5884..6570
                     /locus_tag="G4Z16_RS02320"
                     /old_locus_tag="G4Z16_02310"
     CDS             5884..6570
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013786.4"
                     /locus_tag="G4Z16_RS02320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02310"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_197348924.1"
                     /transl_table=11
                     /translation="MNAGPAGPQFCDELLLHGPGGSVRVVVETAPVRPPRTVAEQHRAG
                     RLATAAALRRAGSRVRTVGRRRDGAPKFPPGIAGSLTHTEDLAVAAVAPGARGVGVDLE
                     PRLPERRLHRFLLNEEERALLWRDGDRAGLRRLFAAKEAAFKALSGYRGAHGGLFWRVR
                     LVLFGDQLWARAGDQYALVRAAAAPDFAFAVAVRLDEPPPFANSPRTQRAWRPATERGP
                     QPPHRL"
     gene            6621..7445
                     /locus_tag="G4Z16_RS02325"
                     /old_locus_tag="G4Z16_02315"
     CDS             6621..7445
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514264.1"
                     /locus_tag="G4Z16_RS02325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02315"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_197348925.1"
                     /transl_table=11
                     /translation="MQAVSYTAQWMAAARALESERDDALFTDPLAEALAEPRGSEMIER
                     YAGGGLLPFISIRTRFLDDAIGDLLADGSIRQVVLIAAGMDTRAFRLRWPDGTDLYEVD
                     HGPLIEEKRRRLEALGATPAVRRHELSADLTQEWLPELEMAGFDPSRPTLWIAEALTFF
                     LTEAQAAGLLRLLASHSAPGSHIALDILGRGLLRNPFSRTFLDRLAADGTPWVFGTDEP
                     EEFLAANGWDVVCLREPGQPGAGEGRWPYQVQPRDRRHANRLWLIRARLAAG"
     gene            complement(7465..8457)
                     /locus_tag="G4Z16_RS02330"
                     /old_locus_tag="G4Z16_02320"
     CDS             complement(7465..8457)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010035526.1"
                     /locus_tag="G4Z16_RS02330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02320"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_197348926.1"
                     /transl_table=11
                     /translation="MDRGALLDQQALEVYRAILFHKEQDSVTLSELLELETDEVEAVLQ
                     RLADLSLLAPSRDAPGTLRAVNPRIGLKMLLRREQDELTWRQQRIEQERAALASLDAEY
                     TASRQSEAGDRVEELHHLDEIRIRLEALAESCTTEFLAFHPGSGPGVGAIQTGRSLIEQ
                     ALARGVKFRSIYLDSIANDRVGRTHAQWMMENNGDVRTSPTLPLQLLVIDTSAAMVAGL
                     PGQSGTSALLFTGQPVVLAMRALFEAYWEHASSANQLVDVSDAPSCELTPQERKLLQLL
                     GTGLTDEAAARALGIGVRTERRMVSELMKRLGASSRFEAGVQATRRRWI"
     gene            9047..9751
                     /locus_tag="G4Z16_RS02335"
                     /old_locus_tag="G4Z16_02325"
     CDS             9047..9751
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181641.1"
                     /locus_tag="G4Z16_RS02335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02325"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_246530638.1"
                     /transl_table=11
                     /translation="MRSQGHTEPRSVPRSRSANGRRAHLASLDASLTVIAADVGFLRQF
                     GGTAAEICGRSICDLLRLNASPALDEHFNRLLDGRSSRFTERVVGLCGPHAGFSAGLTG
                     IAVHTEATSVACAVLLRPDDGSPLPHADGVPHQEREALLPLGARILEGVAGGASTEQLA
                     SRLYLSRQGVEYHVGQMLRQLEVPNRAALVARAHSKGMFAPGVWPPRILPGSVKQFRRR
                     VPATASQGPFCP"
     gene            10001..11068
                     /locus_tag="G4Z16_RS02340"
                     /old_locus_tag="G4Z16_02330"
     CDS             10001..11068
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058774.1"
                     /locus_tag="G4Z16_RS02340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02330"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_197348928.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.7e-50, bitscore:
                     168.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQTLDLGRTSAAETRESVANFLEKFLTEKKEKAVLPQAERLPQ
                     ILAEFLTGGKLIRPLLTVTGWVAAGGARDSEQVVQVAASLEMFHAFALIHDDIMDHSEL
                     RRGRPTAHRQLSADQQGSGARHFGVGAAILLGDLAFTWSDEILHRADLTPVQFASVFPV
                     ISEMRSEVMLGQYLDLRGTGNPTDDVESTLTVSRYKTAKYTVERPLHIGAALAGAGLGT
                     MDVFTAYAIPLGEAFQLRDDLLGVYGDARTTGKSHLDDLRVGKNTTLVALALRAADPGQ
                     AALLHELIGNPSLDEAGAEQVRKIFAETGAKDTVEEMIENRYRESVEALDGAPFAAEAI
                     HALQDLARNATRRTS"
     misc_feature    complement(11072..11084)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    11189..11205
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.09"
                     /tool="antismash"
     gene            11215..12003
                     /locus_tag="G4Z16_RS02345"
                     /old_locus_tag="G4Z16_02335"
     CDS             11215..12003
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="G4Z16_RS02345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02335"
                     /product="hypothetical protein"
                     /protein_id="WP_246530639.1"
                     /sec_met_domain="T1TS (E-value: 3.1e-13, bitscore: 48.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDAELREVMDTCNRAVAPLGKDVSDKRWISYMDVVRWSQSARHI
                     KDMEAFKAVCVLNCVTFVWDDMDPALHRFDLFLPQVSAVCERYYAPQDAAFAYEGARAF
                     ITSDHMFRDSPIKKTLCSTSPEQYFRFRVTDVGVDFWMKMSYPIYRHAEFTEHAKTGLA
                     ARMTTRGLAIVNDFYSYERENALGQITNCFELCDVDDDKDFERFFEERLKDMTEDIECV
                     KAFDETTADILLDLLRGNFVWTTRDRRYKAAVNDVNSFIR"
     gene            12014..13372
                     /locus_tag="G4Z16_RS02350"
                     /old_locus_tag="G4Z16_02340"
     CDS             12014..13372
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000061: Hydroxylation (72% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188169.1"
                     /locus_tag="G4Z16_RS02350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02340"
                     /product="cytochrome P450"
                     /protein_id="WP_246530640.1"
                     /sec_met_domain="p450 (E-value: 6e-77, bitscore: 257.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNTISPPADRTWRTGKAPGALPLLGHVLPLWRDPLGFLASLPSH
                     GDVVEVRIGPGRAYLVNHPELVRHVLLHPRVFDKGGIFDKARQLLGNSLSVSRGEEHRY
                     QRRLVQPAFRPGKIAEYTRAVADDTNSAIAAWSSGDVRNISDEMHALLMRVAARTLFST
                     GLDDATIEEARHCLRTVSLGIYKRAMAPLGVMEKLPTPAKRAYDHANTRLREIVATMID
                     TQRRSPSDRQDLVSTLLRAEHPVTGEKLTDRELLDQVVTFLIAGSETTASTLAFVFHLM
                     GAFPEVEKRVHTEIDEAVGDRAPAYEDLPSLPYTRNVITEALRLYPPSWMAMRVAVEDV
                     ELGGLPVRSGAMVLYSAYAMHRNPELFPSPETFDPGRWEADRAARVPRGALLPFGAGSH
                     KCIGDVLALTETTLIVAAIAAGWRLRPVPGTRLRPEPRATLEAGPLPMICERR"
     gene            13461..14696
                     /locus_tag="G4Z16_RS02355"
                     /old_locus_tag="G4Z16_02345"
     CDS             13461..14696
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953398.1"
                     /locus_tag="G4Z16_RS02355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02345"
                     /product="cytochrome P450"
                     /protein_id="WP_246530641.1"
                     /sec_met_domain="p450 (E-value: 3.3e-12, bitscore: 44.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSLHDCEAVAIDPAGADIPAEAARLRALGDLVPVELPGGIRAW
                     APTRHHILKSFLTDPNVSKDPRRHWETWRSGALHENPEAHWIYNWVGVENMLTAYGDDH
                     SRLRKLIAPAFTARRTEALRPAVETITTDLLDALRTTPPGERVDLRAHYALPLPMRVIC
                     DLFGLVAGEGAQVAAFVEVMMDTTTAPEIAGKMLAGARETLTQLIDRKRAEPGEDLTSA
                     LIAAHDGQDRLSETELVDTLILLLAAGHETTVNLIGNAVVALLRNPDQLAALRAGDVPW
                     TNAVEETLRWAPSIANLPLRFAVSDISVGSVTIRAGEAILTTFGAAGWDPEFHGADAHR
                     FDVRRTPSEHLAFGHGAHRCVGAPLARAEAIIALPALFDAFPAMRLAEEEFEPVPSFVA
                     HGHRTLTVRLRP"
     misc_feature    complement(13480..13498)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.98"
                     /tool="antismash"
     gene            15051..16373
                     /locus_tag="G4Z16_RS02360"
                     /old_locus_tag="G4Z16_02350"
     CDS             15051..16373
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="G4Z16_RS02360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02350"
                     /product="aromatic acid/H+ symport family MFS transporter"
                     /protein_id="WP_197348929.1"
                     /transl_table=11
                     /translation="MTSDSAPAEPAPATPQPGPAGRTRSRALVVALCCATIIIDGYDLI
                     VYGTVVPSLLDGSAEWKLSEAETGRIGAYALVGMLFGAMMTGTVTDLVGRRRIMLGCIA
                     WFTAAMGIAAIAPTPDFFGFARFLAGLGLGGVVPTAIALTIEYAHPRHRSRTNGLMFSG
                     YSVGGILAALTAIVVIPQLGWRAMFWVGVVLGVVLLPIAWRLLPESASFLLARGRRDEA
                     ETLARRYRLALEEPPAAGADAPRGLSTLKALFVPRYVAGTLLFWLGTGVGLLLVYGLNT
                     WLAQIMREAGYPLGSALAFLLVLNLGAIIGTPLFGALADRVGSKPVTLGMFLTAALCIF
                     LLSFELPSFLLFVLVGIAGACTIGTTILVNAYTANFYPAHMRATGLGWALGVGRLGAIL
                     GPIYGAFILASGWGLDANFYAFAAPAVLGAVSMLLIPALRK"
     gene            16436..18139
                     /locus_tag="G4Z16_RS02365"
                     /old_locus_tag="G4Z16_02355"
     CDS             16436..18139
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059173.1"
                     /locus_tag="G4Z16_RS02365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02355"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_197348930.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.4e-39, bitscore:
                     133.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.9e-22, bitscore:
                     76.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVAEAVGRTLVRLGADRAFGVVGSGNFHVTDAMVAAGARYVAAR
                     HESGAAVMADAYARVSGKLGVVTVHQGCGLTNALTGVTEAAKSRTPLVVLAADTPAADL
                     RSNFRVDQDALAHAVGARAERVHGADTAVADTVRACRLAVSGRRTVVLNLPIDVQSRQV
                     PEPLPEPDPLRLHRPAPAPEAVAELARLLGQSRRPVFIAGRGALPRPCAEEAEERSAAD
                     ALRELGAATGALLATSAVARGLFHGDPWSLDVSGGFSSPLAAELISEANLVVGWGCALN
                     KWTTRHGSLIAADASLVQVDVEAEAIGAHRPVDLGIVGDTAATASAVTALLAGDERSPA
                     RGQLQNGRRGYRSPEVGARIERELAWNTVPYTDDSTGENIDPRTLSIRLDQLLPRERVL
                     AVDSGNFMGYPAMFLSVPDERGFCFTQAFQSIGLGLATAIGAALARPDRLPVAALGDGG
                     ALMGVSELETVVRLGLPMAVVVYNDRAYGAEVHHFAGDGVDLSTVTFPDTDIAALARGL
                     GYTAVTVRGEGDLEPVAAWVDGPRSTPLLVDAKITSTEGSWWLKEAFRGH"
     gene            18325..19554
                     /locus_tag="G4Z16_RS02370"
                     /old_locus_tag="G4Z16_02360"
     CDS             18325..19554
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715018.1"
                     /locus_tag="G4Z16_RS02370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02360"
                     /product="MraY family glycosyltransferase"
                     /protein_id="WP_197348931.1"
                     /sec_met_domain="Glycos_transf_4 (E-value: 6.4e-36,
                     bitscore: 122.3, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREYLLTLCVTAAVTYLLTAPVRKFAILIDAMPQIRARDVHREPT
                     PRLGGIAMFGGLCAGLLVAGQLTNIHEVFETTSEPLALLSGASVVGLLGVLDDKWGLSA
                     LLKLGGQVIAAGVMVLQGLTVLWLPIPGVGPVPLSEEQGMFLTVTVVIVTINAVNFVDG
                     LDGLASGIVCIAAMAFFMHAYRMWYGYGIEGAAPATLFAAVLIGMCLGFLPHNIHPARI
                     FMGDSGSMLIGLVIAASAVSVTGQVDSDLLVERAGSSREATHAMMPVYIPLLLPLTVIA
                     LPVADLLLAIVRRVWKGRSPFAADRGHLHHRLLDIGHSHRRAVFVLYFWSALIAFGTIA
                     LSVHDGSVWVAAGIVPFGLVGLVLLLLPRLAPRRARRPGTAGSTPRTQDAYDAERRELS
                     GTAEGGPHQP"
     misc_feature    19632..19646
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(19698..19707)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            <19735..19884
                     /locus_tag="G4Z16_RS02375"
                     /old_locus_tag="G4Z16_02365"
                     /pseudo=""
     CDS             <19735..19884
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998795.1"
                     /locus_tag="G4Z16_RS02375"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02365"
                     /product="dienelactone hydrolase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AAGVRYSSEVYPGTIHGFTMSDTDTFDASALQRHWDRLLPLLDRT
                     LNNA"
     gene            complement(20106..20669)
                     /locus_tag="G4Z16_RS02380"
                     /old_locus_tag="G4Z16_02370"
     CDS             complement(20106..20669)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123057.1"
                     /locus_tag="G4Z16_RS02380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02370"
                     /product="DinB family protein"
                     /protein_id="WP_197348932.1"
                     /transl_table=11
                     /translation="MTRSERIADQLDRHWHKNLRPRLHGLADEEYFWEPVRGCWSIRPR
                     GTSAAPMSAGSGKWTMDSASPDPVPAPVTTIAWRLAHIIVSCLGYRVGWHFGGQDVDSQ
                     TFAYAGTADEALEQLDEMYGRWNAGVRELSDADLDNPPTVGPERFPMEGIVLHVNRELI
                     HHGAEISLLRDLYRWQDGAVPRRK"
     gene            complement(20758..21303)
                     /locus_tag="G4Z16_RS02385"
                     /old_locus_tag="G4Z16_02375"
     CDS             complement(20758..21303)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012360.4"
                     /locus_tag="G4Z16_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_02375"
                     /product="gamma carbonic anhydrase family protein"
                     /protein_id="WP_197348933.1"
                     /transl_table=11
                     /translation="MPVYAFDGVRPRVSADAYVHPDAVLIGHVSLGPESSVWPGAVLRG
                     DHGRIEVGARTSIQDGTIIHTTKEWPTIIGDECVVGHNAHLEGCTVADRCLIASMSTVL
                     NRAVVGTGSVVAAAALVPEGLDVPEHSMVLGVPGRVKPLPDDRLKGRVDHGVDVYVDFA
                     RRYPKAMTRVDVDDCRVD"
ORIGIN
        1 ccggacgcca acgtgccgac ctccatccgg tccagcggca tccccgtgct gcacggatcc
       61 gtttcggagc tggactccat cctcagcacc tggctcgcgg cgcaccccga gggaaccgcc
      121 tgcgtcatcg gcgatcccac gttccggcct acgtcccgcg tgcggtcgct gaccccggag
      181 ctgtcgaagg gactggaatt cgacctggtg gtgctcgtcg gccccgagga gttcggcaag
      241 ggcgtcgatg gcatcgaagg aggggtcgac cgctacgtgg cgatgacccg ggcgacacag
      301 cagctcgtca tcctccccag ttcctgacgc cgtacgggac cgatgccggg gagacaacac
      361 cgcccggccg cagggaagtt cagcccggga cgccgacggg cggcccggaa cactgcgtaa
      421 tcggctcgcg cccgggtgtg catgcgcctt agcctgcgcg ccatgtcaac ggcacccgtt
      481 ctcacgcccc cgggcggacg acttcccgcg ctggtaccag gacctgatca gcaaggccga
      541 actggccgag aacgggccgg tccgcggcac catggtcatc cggccgtacg gcagtggctg
      601 tcagcgacgc agttgggcgt tgagccgggc ggcctggcgc gtcaggtgtt cacgctcggc
      661 gaggttgggt gccttctcgg ccgcctcgac gtacagccgt gccgccttcg ccaggttccc
      721 gtcgcgctcg tggaggtacg ccgctaccgc ggcacggcgg ggcaacgagt ctccccggct
      781 cgaagacccg ctcggtgcgg actcgtccag cgccgcgagc gccacaaggc cggcgcgcgg
      841 tccgtcggcc tcccctacgg ccaccgcgcg gttgagccgg acgaccgggc tgtcggtcag
      901 gcgcgtgagc tcgtcgtacc actcgacgat ctgcacccag tcggtctcct cggcggtggg
      961 cgcgtccgcg tggagtgccg cgatggcggc ctgcgcctgg aactcgccca gccggtcgcg
     1021 ggcgagagcc gcctgcagga tctccacgcc ctcggcgatc agtttcgtgt cccaccggcc
     1081 gcggtcctgc tcggcgagcg gcaccaggct gccgtcgggc gcggtccggg cggcgcgccg
     1141 ggcgtggtgg agcagcatca gcgcgagcag cccggccacc tcggggtggt cgaaggcggc
     1201 cgcgagctgc cgggtgagcc ggatggcctc ggcggcgagg tcgacgtcgc cggagtaccc
     1261 ctcgttgaag acgaggtaga ggacgcgcag cacggtggcg gcgtcaccgg gctggtcgaa
     1321 ccgcacgccg gagacggtgc gcttggcccg gctgatgcgc tgcgccatgg tcgcctcagg
     1381 caccaggtag gcctgcgcga tctggcgggt ggtcagcccg ccgacggcgc gcagcgtgag
     1441 ggcgaccgcg gacgacggcg tcagcgacgg gtgggcgcac aggaagtaga gctgaagcgt
     1501 gtcgtccgcc gcgggcacgg gcccgggtgc cggttcctcg tcgacgaggt cctcgcgccg
     1561 gcggcgggcg gtctccgccc gggtcgcgtc gaggaaccgg cgccaggcca cggtgaccag
     1621 ccagcccttg gggtcccggg gcggttcggc cggccagacg cggaccgcct cgaccagcgc
     1681 gtcctgaacg gcgtcctcgg ccgccgcgaa gtctgctccg cggcggacga ggatcccgag
     1741 cacgctcggc gtgaggctcc tgagcaagac ctcgtccacc tgagaggtca ctccgtgatg
     1801 gtggggggct cggtcaggaa cgggcgcagc tcgagccact catggatcgg cttcccgtcc
     1861 gcccccgggg cggccgacag ctccccggca agctcgacgg cgcgctcata ggtgtccacg
     1921 tcgatcacca tccagccggc gatgacgtcc ttggtctcgg cgaacggtcc gtcggtgacc
     1981 ggcgggcgcc cctctccgtc gtagcggacc catgtcccct cgggggcgag cgcctgaccg
     2041 tcgacgaact cccctgtctt ctccagccgg gccgcgaagt cgttcatgta ctggatgtgc
     2101 gccgagatct cctccggctt ccactggtcc atgggcacgt cgttgaccgc cgccggtgcg
     2161 ccgcggtagt gcttgagcag caggtacttg gacatcgtgt ctctcctcgg tactggtgcg
     2221 accattctgg ccgcgttcat accggggacg gagccggtcc cgggttctcg acatcaccgg
     2281 ccaagatttt ttgccctcat cggagaagcc cgggtgagcc gtcccgtcgt gtccggcaac
     2341 aggcccggcg cagcgtcgga cgccgctggt cacgggaccg tgccgtgagc cgtcccgtcg
     2401 aagtaccggt cctggagttc ccgtgccctt ctgcggacgc gagcgattcc cgagggccgg
     2461 ttgaacgggg catagggcgg ccacaggaag acgaggacgg cgagctcctc tgccaccagg
     2521 gcgcgttcca gagcgacgcg gtcgcagcgg cggccgtcca gacaggagtg gatcagctcg
     2581 cgagggaccc tcactcgttg cccaaccgcc cgccgccggg ccctcgcggc cgcggcaggc
     2641 cgaccgcagg cgcggcacca gagcctgcag ggcgacctcg tgccgggcac ggacgagcac
     2701 gccctagcct ccgcgcgctg ccgctgacca gcgctttcgc tatcactagg gtattcccta
     2761 cctccgcgcg gcaaagaggg catccccgca cacgccctgc ctaatctgtg ggccgtcacc
     2821 ttgcacggcc gttcggcacg caacctcacc cggccccccg ccgggtgcgc cgctgtgcct
     2881 gaacgggccc ccgcgcagcc gctgttcccc ggcacacaca ccgcttggcc aaatgagccg
     2941 gcgcacgacc gcacttccca ggaaagaggt ctgccgatgg cgacgaccgt caagccggtg
     3001 aagctggatc tgcaccggct cgaagtgatg gcggagtccg actactacaa cccgtacacg
     3061 gtcttcgact ggccggacac cctggaggag gaccggccgt ggatgagcga ggacctggtg
     3121 accctcgccg ggacggagaa gtgggacgag ctgacacgtg agcagcaact cgccctgacc
     3181 cgccatgagg ccgtgaactt cttcagcctc aacgtgcacg gcatccggga actgctcagc
     3241 gaagtcgtgc tccgcatcca caccaggact tatgccgaag cctcggagtt cctccaccac
     3301 ttcatcggcg aggagaacga gcacatgtgg ttcttcggga ccttctgccg ccgctatctg
     3361 ggcaaggtgt atccggcggt cccgcaggtg ggcgtgagcc ggctggaggg cgtgagcgag
     3421 gccgcacacg agttgctggt cttcgcgcgc attctgatct tcgaggagat cgtcgactac
     3481 ttcaacgccc gcatggccac ggaccaggcg ctcccgcaca tcgcacggga gatcaaccgc
     3541 gtgcaccacc aggacgagag ccgccatgtc gcgttcggca ggcgcctgtt cacgcagctc
     3601 ctgacccagg ttcaggagaa cagtccgcag gacgtcccgg ttctggcgga gtacctggag
     3661 aagtacctgc agtacagcgt ccagagtctc tacaacccgg ccgtctaccg cgacgccggg
     3721 ctggccgagc ccctggagct gaggcgtcac cttctggcgc accccgcccg ccacgccgcg
     3781 cacgaccgca tcctgcagcg cacgcggaga ttcctcgcac gcagcggcct cgacacgcag
     3841 ggagccacgg catgagcgac gacaagatcg ccaagatcct cgccttcatc cacgagcgca
     3901 acccggaagc gggtgaactg ggcctggacg acgacctgat cgaccgacgg gcggtcgact
     3961 cgcttgcctt cgtcgagttc ctctacctgc tggaggagct gagcggcgag accatcgatc
     4021 cggaggagct cgacctcgag gacttccgca cgctccgggc catcgacaag cgcttcctct
     4081 cgggagcggt gcactgatgg acaccggcac cgggacgacg gtgaacgacg ggctggacgt
     4141 gctcggcgcg gacgaactgc gcctgctgcg cgtcctcgat gacctgttca cggaatgggg
     4201 ggtgcgactc ggcgccgagg agcgccgcta cccgttcctg ctgaagccgc gtgaactcga
     4261 agacgtcgac tactacgaga acttcccgca cctggggctg gccgcggcga cggccgatcc
     4321 caagctgctc ggcgaactgc gggccgtccg cgaggccccg ctcgccgaac tgccaacgga
     4381 ggtcctccac gacgccgctc tggcgctgcc ttcggccgcc tgctactcgg tctacttcca
     4441 tctgcgcggg cagacgctgc cgtcggagga gaaccgggtc accacccgcg cgacctgctt
     4501 ccgcaatgag acgcagtacg agggcctgcg gcggctgctc ggcttctcca tgcgcgagat
     4561 cgtcttcgtc ggccacgccg ccggcgccac ggagcacctg gagcggacca aggagctggt
     4621 gctgggtttc gcggacgcac tcggcctcgc gatggacacc cgcacggcaa ctgacccgtt
     4681 cttcgacagc cgcagttcgc gcgccaccat gcagcggctg ttcccggtga aggaggaatt
     4741 cgtcgtcgac ggtctggccg tcggctcggt gaactaccac cgcaacttct tcggggagcg
     4801 ctgcgccatc gccctcccgg acggcacgcc cgcgtccacc agttgctgcg ccttcggtct
     4861 ggagcgatgg gtgcacatcc tcagcacccg cttcagcggc gcccgtgacg ccgccgaggc
     4921 agtagctcgc agcagcgtga acgcgtgaac tctcccttcc gccctccgac ttcccaccga
     4981 aggtgaaccg atgaccgaca tgaccgtcga cgacgtgctc gagaccggca ccgtccaggt
     5041 gtccgacgac atccggctca gctacgagag acgcggatcc ggcacggaca tcgtgctgct
     5101 caacaacttc ttcgtggacc gcaagtcctg gcgggcctac acgggggacc tcgccgctgc
     5161 ggcacgcctc accgcctacg acctgagagg tcagggcgaa tcgaccccgc tggccgacga
     5221 accggtgtgg gaggagcaca tcagcgacct caaggcgctc ttcgacggtc tgggtatcga
     5281 gaaggcgttc ctggtgggca cgtccttctc gacgctgctc tgccgggact tcgcgatcgc
     5341 ccacccggac cgggtgcacg ggctggtgct cgccagtccc gcgctgagcc cgtacgggcc
     5401 acagcggctg cgccggctca ccaagtcctg gctgcacacg ctcgacacct cgggcctggc
     5461 cgtcctgcac gaccaggtct atccgctggt gtgcagcgac cgtgccgtgg aggaggtggg
     5521 caccgccgga ttcctgggtt acaagcagaa cttcctcggc atccacaccg tcgagtcgct
     5581 gcgggccggc ctgctggcct cgacgaaggc gcccctcgac ccgcagaccc tcacccaagt
     5641 gcggcagccg acactgctgt tcgtcggcgg cgacgacttc tcgctgagcc tcgacgcaac
     5701 ggaacggctg accaagctcc tgccggacgc caccgcggtc atcgtgccgc acggcgggca
     5761 cgcggccttc gtcgaggagt ccgagtggtt caaccgggaa gtgctggcct tcgtccggcg
     5821 agtgaccgga acggatgagt gagcccgctc cttcccggaa cgtctccacc tggacgggca
     5881 gcggtgaacg ccggtcctgc cggtccgcag ttctgcgatg agctgctgct gcacggcccc
     5941 ggcggcagtg tgcgcgtcgt ggtggagacc gctccggtgc gtccgccccg caccgtcgcc
     6001 gagcagcacc gcgccggtcg cctggcaacc gccgcggcgc tgcggcgggc cggaagcagg
     6061 gtgagaaccg tgggccggcg gcgcgatggt gcaccgaagt tcccgccggg catcgccggc
     6121 tccctcacgc acaccgagga cctggccgtg gcggcggtgg caccaggcgc ccgcggagtc
     6181 ggcgtcgacc tcgaaccgcg cctcccggag cggcggttgc accggttcct gctgaacgag
     6241 gaggagcgtg ccctgctgtg gcgggacggt gaccgggcgg ggctgcggag gctgttcgcc
     6301 gcgaaggagg ccgctttcaa ggcgctgtcc ggctaccgcg gcgcgcacgg cggtctcttc
     6361 tggcgggtcc ggctcgtcct gttcggggat cagctgtggg cgcgtgcggg tgaccagtac
     6421 gcgctggtcc gggcagccgc cgcgccggac ttcgcgttcg ccgtggcagt ccgcctcgat
     6481 gagcctcccc catttgccaa ctcgccccgc acgcaacggg cttggcgtcc ggcaacggag
     6541 agaggaccac agccgccgca tcgcctgtga gtgggagctc cgcgagtcat ccgagtcacc
     6601 cgagaaggga ccacggaccc atgcaagccg tttcctacac cgcccagtgg atggccgccg
     6661 cccgcgcgct ggaatccgag cgcgacgacg cgctgttcac cgacccgctg gccgaagcgc
     6721 tcgccgagcc caggggctcc gagatgatcg aacgctatgc gggcggcggg ctgctgccgt
     6781 tcatctccat ccgcacccgc ttcctggacg acgcgatcgg cgacctgctg gcggacggct
     6841 ccatacggca ggtggtgctg atcgccgccg ggatggacac ccgggcgttc cggctgcggt
     6901 ggcccgacgg caccgatctg tacgaggtcg accacggccc gctcatcgag gagaagcggc
     6961 gccgcctgga ggccctcggc gcgacgccgg cggtgcggcg ccacgagctg tccgccgatc
     7021 tcacccagga gtggcttccc gagttggaga tggccgggtt cgatccgtcg cgccccacgc
     7081 tctggatcgc cgaggcgctg acgttcttcc tcaccgaggc tcaggcggca gggctgctcc
     7141 ggctgctggc ctcccactcg gctcccggca gccacatcgc tctcgacatc ctcggcagag
     7201 gactgctgcg caaccccttc tccaggacct ttctggaccg cctggccgcc gacggcactc
     7261 cgtgggtctt cggcacggac gagcccgagg agttcctcgc ggccaacggc tgggacgtcg
     7321 tatgcctcag ggagccgggg cagccgggcg ccggtgaggg ccgctggccc taccaggtcc
     7381 agccccgcga ccgccgccac gccaaccgcc tgtggctcat ccgcgcacgc ctggcggcgg
     7441 ggtgacgcac tcgcgggccc cgggtcagat ccaccgccgg cgagtggctt gcactccggc
     7501 ctcgaaccgg ctggaggctc cgagccgctt catcagctcg ctcaccatcc gccgctccgt
     7561 gcggaccccg atacccaggg cgcgcgccgc ggcttcgtcc gtgaggccgg tgccgaggag
     7621 ctggagcaat ttccgctcct gcggggtgag ttcgcaggac ggagcgtcac tcacgtcgac
     7681 gagctggttg gcggacgagg cgtgttccca gtacgcctcg aagagcgcgc gcatcgcgag
     7741 caccacgggc tgcccggtga agagcaacgc cgacgtcccg ctctgcccgg gcaggccggc
     7801 gaccatcgcc gcgctcgtgt cgatgacgag cagctgcagc ggcagggtcg gggaggtccg
     7861 gacgtcgccg ttgttctcca tcatccactg ggcgtgcgtc cggcccacac ggtcgttggc
     7921 gatgctgtcg agatagatcg agcggaactt cacgccccgc gccagcgcct gctcgatcag
     7981 ggaccgtccc gtctggatcg cccccacccc cggtccgctc ccggggtgga aggcgaggaa
     8041 ctcggtcgtg caggactcgg cgagggcctc cagccggatc cgtatctcgt cgaggtggtg
     8101 caactcctcg acgcggtcgc cggcttcgga ctggcgggaa gcggtgtatt cggcgtccag
     8161 tgacgcgagt gctgcccgct cctgctcgat gcgctgctga cgccaggtca actcgtcctg
     8221 ctcacgccgc agaagcatct tcaggccgat ccgggggttc accgcgcgca gtgtgccggg
     8281 cgcgtcccgg gaaggagcca ggagggagag gtcggccaag cgctgaagta cggcctccac
     8341 ctcgtcggtc tccaactcca gcagctcgct gagcgtcacc gagtcctgct ccttgtggaa
     8401 gaggatcgcc cggtacacct cgagggcctg ctggtcgagc aacgcgcccc tgtccaattg
     8461 cccccctgag aacccgtgtc acatgccgcc cgtaggccgg gccggtgccg gccatccggt
     8521 gcccgcggca acgatccgtt ccgaccggct gaaaatcccc ccgacgctac ccagccggag
     8581 gacccggtat ccgccgcgcc ggtccgcgga ccgcacctgc cgcgccgcgg gccccgttgc
     8641 cggtcacggc gagattggac cacatgcggg gcgcctgccg ggcggcgttc gcgatagtgg
     8701 gctgcccgag cggcgcggca cccaccgagg ctgtgcgcga atctgccgcc gcagagtgac
     8761 gaccgggacg cccggggccg ccaattcagg acggcgacag aacgggatct tccgcacgga
     8821 tcgccctgtg cagcttgctg cccggcagct tgttgcctgc ggcggcgtga ccccaggagt
     8881 gccccgcctt gggaatatgt cccccggtcc ggccgcgcag acgcgctcgg ctctgcgcct
     8941 gccggacgca gtcccccggc gtgtggtccc gcgctcgtca tgcgcgcccg gccacacgtg
     9001 gcgcagtggt cgcacgtccg tatgcattcc gagaaaggtc tgcgttgtga gatcgcaagg
     9061 gcacaccgaa ccccgctccg tcccgcgttc ccggtcggcc aacggccggc gggcccatct
     9121 ggccagcctg gacgcctcgt tgaccgtcat cgcggcggac gtgggattcc tgcggcagtt
     9181 cggcggcacg gcggccgaga tctgcggccg gagcatctgc gacctgctgc gcctcaacgc
     9241 ctcccccgca ctcgacgagc acttcaaccg gctgctcgac ggccgcagtt cgcgcttcac
     9301 cgagcgtgtg gtcggtctct gcggtccgca cgccggcttc tccgccgggc tgacgggaat
     9361 cgccgtgcac accgaggcca cctccgtggc ctgtgccgtc cttctccgac cggacgacgg
     9421 ttcgcctctc ccccacgcgg acggcgtccc ccaccaggaa cgggaggcgc tgctacccct
     9481 cggtgcccgg atactcgaag gcgtcgcggg cggcgcctcg accgagcagc tggcttcccg
     9541 tctctacctc agcaggcagg gcgtggaata ccacgtgggg cagatgctcc gtcagctcga
     9601 agtgcccaac cgcgccgccc tcgtggcccg agcccactcc aagggcatgt tcgcgccggg
     9661 tgtctggccg ccgcggatcc ttccggggtc cgtcaagcag ttccgccggc gcgtacctgc
     9721 caccgcttcg caggggccct tctgtccgta gggaccaagg gaatgcgccg ggccccaacg
     9781 tggcgtcttt cccgtccgat tgacgtggac ctcggcgacc gaaggctcag cggtcaccgc
     9841 gcgggcccgg gagacgaatg tggcggtgat cggccaatga attcccgacc gcgcggcagt
     9901 tcctgtccgg cgttccaccg tgcacttccc ggtgcctgag tcgcgcgccc gtcccggacg
     9961 gtgagtccgg tcgggcgaac cttcgaggga gaagaacaac atgagcacgc agacgttgga
    10021 tctcggcaga accagcgcgg cggagacgag agagtccgtc gcgaatttcc ttgagaagtt
    10081 cctcaccgag aagaaggaga aggccgtact cccgcaggcg gagcgactgc ctcagatcct
    10141 ggcggagttc ctcacgggag gaaagctcat ccgccccctg ctcacggtga ccggatgggt
    10201 ggcggcgggc ggggcgaggg acagtgaaca ggtcgtacag gtcgccgctt cactggagat
    10261 gttccacgcg ttcgccctga tccatgacga catcatggat cacagtgaac tccgcagagg
    10321 ccgccccacc gctcaccgcc agctctccgc ggatcaacag ggctccggtg ccaggcactt
    10381 cggtgtcggc gcggcaatac tgctgggcga tctcgctttc acgtggtccg acgagatact
    10441 gcaccgggca gacctcactc ccgttcagtt cgcatcggtt ttcccggtca tcagcgagat
    10501 gcgcagcgag gtgatgctgg ggcagtatct cgatctgcgg ggcacgggaa acccgacgga
    10561 cgacgtggag tcgacgctga cggtcagccg ctacaagacc gccaaataca cggtcgagcg
    10621 gcccctgcac ataggagcgg cccttgcggg cgccggcctc gggaccatgg acgtcttcac
    10681 cgcgtatgcc attccgctgg gcgaggcctt ccagctccgc gacgatctgc tcggcgtcta
    10741 cggcgacgcc cggacaaccg ggaagtccca tctcgacgac cttcgcgtcg gcaagaacac
    10801 cacgcttgtc gcgctcgccc tgcgtgccgc cgaccccgga caggccgccc tgctgcacga
    10861 gttgatcgga aatccctccc tggacgaagc gggtgccgaa caggtgcgga agatcttcgc
    10921 cgaaacaggc gccaaagaca ccgtcgaaga aatgatcgag aaccgctacc gggagtccgt
    10981 cgaagcgctg gatggtgcgc cgttcgccgc tgaggcgatt cacgccctcc aggatctcgc
    11041 ccgcaatgcc actaggagga cgtcatgacc cctgacaccg tcacccggca ccccgcgccg
    11101 ctcgcggacg gcgtttccca aggcaccgga atggcgcgtc gcctgccggg atgtacggac
    11161 agattcgcct cgctgttctc tcagcatgtt gcgcacgagg cggaaaaggt gccgatgtcg
    11221 gacgcagaac tgcgcgaggt catggacacc tgcaaccgtg cggtggcgcc gctggggaag
    11281 gacgtctccg acaagcgctg gatctcgtac atggacgtgg tccggtggtc ccaatccgcc
    11341 cgccacatca aggacatgga agcgttcaag gctgtctgcg tgctgaactg cgtcaccttc
    11401 gtgtgggacg acatggatcc cgcgctgcac cggttcgatc tctttctgcc ccaggtgagc
    11461 gcggtgtgcg aacgctacta cgcaccacag gacgcggcat tcgcctatga gggagcccgc
    11521 gcgttcatca ccagcgacca catgttccgc gattcgccga tcaagaagac gctctgcagc
    11581 acctctcccg agcagtactt ccggttccgg gtcaccgacg tcggcgtgga cttctggatg
    11641 aagatgtcct acccgatcta ccggcacgcg gagttcaccg agcacgccaa gacggggctc
    11701 gccgcacgca tgaccacgcg cggactggcg atcgtcaacg acttctactc ctacgaacgc
    11761 gagaacgcgc tcggccagat caccaactgc ttcgaactgt gcgacgtgga cgacgacaag
    11821 gacttcgagc gcttcttcga ggagcggctg aaggacatga cggaggacat cgaatgcgtc
    11881 aaagccttcg acgagaccac cgcggacatc ctcctggacc ttctccgcgg caacttcgtg
    11941 tggacgacac gtgaccggcg ctacaaggcg gccgtgaacg acgtcaactc gttcatccga
    12001 taggagccgc ccggtgccga acacgatctc tcccccggcg gaccgcactt ggcggaccgg
    12061 caaggccccc ggcgccctcc cgctgctggg gcacgtcctt ccgctctggc gcgacccgct
    12121 gggcttcctg gcctcactgc cctcccacgg cgacgtggtc gaggtccgca tcggccccgg
    12181 ccgcgcctac ctcgtcaacc atcccgagct ggtcagacac gtactgctcc acccgcgggt
    12241 cttcgacaag ggcgggatct tcgacaaggc gcggcaactg ctcggcaaca gcctgtccgt
    12301 gtcccgcggt gaggagcacc ggtaccagcg ccggctcgtc cagcccgcct tccgcccggg
    12361 gaagatcgcc gagtacacgc gcgccgtcgc cgacgacacg aactcggcga tcgccgcatg
    12421 gagttcgggc gacgtacgga acatcagcga cgagatgcac gcactgctga tgcgcgtggc
    12481 cgcgcggacc ctcttctcca cgggtcttga cgacgccacg atcgaagagg cccggcactg
    12541 cctgcgaacc gtttccctgg ggatctacaa acgggccatg gcaccgctgg gagtcatgga
    12601 gaagctgccc actccggcga agcgcgccta cgaccacgcc aacaccaggc tgcgggaaat
    12661 cgtggcgacg atgatcgaca cccagcggcg gtccccctcc gaccggcagg atctggtgtc
    12721 gacgctgctg cgtgccgagc atccggtgac cggggagaag ctcacggacc gcgaactgct
    12781 ggaccaggtc gtcacgttcc tgatcgccgg cagtgagacc acggcctcga cgctcgcctt
    12841 cgtattccac ctgatggggg ccttccccga ggtcgagaag cgggtccaca cggagatcga
    12901 cgaggccgtc ggggaccggg ctccggccta cgaggacctg ccgtcactcc cctacacgcg
    12961 caacgtcatc accgaggcgc tgcgcctcta cccgccgtcc tggatggcga tgagggtggc
    13021 ggtcgaggac gtcgaactcg gcggcctgcc ggtccggtcg ggcgccatgg tcctctacag
    13081 cgcctacgcc atgcaccgca atccggagct gttcccctcc ccggagacgt tcgaccccgg
    13141 gcgctgggaa gcggaccggg ccgcgcgggt gccccgcggc gcgctgctgc cgttcggcgc
    13201 cggcagccac aagtgcatcg gcgacgtgct ggcgctcacc gagacgacgc tcatcgtcgc
    13261 ggccatcgcg gcgggttggc ggctgcgccc ggtgcccgga acccggctgc gcccggaacc
    13321 gagggcgacg ctcgaggccg gaccgctgcc catgatctgc gaacggcgtt gacccccgcg
    13381 tgcacccgcc cgcttcgtgc gccgcacctc atgtcccacc ggctttatcc ccgtcaccgc
    13441 cgcaaccgag gagagctccc gtgacccagt ccctgcacga ctgcgaagcc gtcgccatcg
    13501 accccgccgg ggccgacatc cccgcggagg cggcccggct gcgggcgctc ggcgacctgg
    13561 tgcccgtcga actgcccggc gggatacggg cgtgggcacc gacccgtcac cacatactca
    13621 agtcctttct gaccgacccg aacgtcagca aggacccccg ccggcactgg gagacctggc
    13681 gcagcggtgc gctgcacgag aaccccgagg cccactggat ctacaactgg gtcggtgtgg
    13741 agaacatgct caccgcctac ggcgacgacc attcgcggct tcgcaagctc atcgctcctg
    13801 ccttcaccgc ccgacgcacc gaagccctgc gtcccgccgt cgagaccatc accaccgacc
    13861 tgctcgacgc gctgcgcacc acaccgcccg gcgagagggt ggacctgcgt gcccactacg
    13921 cgctgcccct ccccatgcgc gtgatctgcg atctcttcgg cctcgtcgcc ggcgaaggcg
    13981 cgcaagtggc cgcgttcgtc gaggtgatga tggacaccac caccgcaccg gagatcgccg
    14041 gaaagatgct cgccggcgca cgcgaaaccc tcacgcagct gatcgaccgc aagcgcgccg
    14101 agcccggcga ggacctcacg tcggcgctca tcgccgccca cgacggccag gaccgtctga
    14161 gcgagaccga actcgtcgac accctcatcc tcctcctggc ggcgggccac gagaccacgg
    14221 tcaacctgat cggcaacgcc gtcgtcgcgc tgctgcgcaa tcccgaccag ctcgcggccc
    14281 tgcgcgccgg cgacgtgccc tggaccaacg ccgtggagga gaccctgcgc tgggcgccgt
    14341 ccatcgcgaa tctgccgctg cggttcgcgg tgagcgacat cagcgtcggc agcgtcacca
    14401 tccgggccgg cgaagcgatc ctgaccacct tcggcgccgc cggctgggac ccggagttcc
    14461 acggcgcgga cgcccaccgc ttcgacgtcc gccgcacgcc ctccgagcat ctggcgttcg
    14521 ggcacggggc gcatcgctgc gtcggtgctc cactggcccg cgccgaggcg atcatcgcgc
    14581 ttccggccct cttcgacgcc ttccccgcca tgcgactggc ggaggaggag ttcgaaccgg
    14641 tgccgtcgtt cgtcgcgcac ggccaccgca ccctgacggt gcgtctgcgt ccgtagtgcc
    14701 gcaggcccgg cggggacgga cggcgaccgc ttctgcggcg ccgtccgccg cgcgcgggcc
    14761 catccgcgct ccagcacgca ctctccggtg ggctgcgaac ggcccacggt gcacggccag
    14821 ttgagggccc ggcctgggga cggccggagc ggaacgaccg cccggcgcag gtggggaggc
    14881 gaagcccggg aagggggtgg cggagtacgg gcaggcgcag agtcttccgc cccgttgccc
    14941 ggcgtgattt cctgtggccc cccacgcgcc tcaccagggc ctcccccggc catgccgtcc
    15001 cccagtgcgc gccgcatcac agcgcacgca tcgctcccct cggagatcgc gtgacttctg
    15061 actccgctcc cgccgaaccc gcccccgcga cgccgcagcc cgggcctgcc ggccgtaccc
    15121 gctccagagc ccttgtcgtc gccctgtgct gcgcgacgat catcatcgac ggctacgacc
    15181 tgatcgtcta cggcaccgtc gtgcccagcc tcctggacgg ctcggccgag tggaaactct
    15241 ccgaggccga gaccggacgc atcggtgcct acgcgctcgt cggcatgctc ttcggcgcca
    15301 tgatgacggg caccgtcacc gacctcgtcg gccgcaggcg catcatgctc ggctgcatcg
    15361 cctggttcac ggcggccatg gggatcgcgg cgatcgctcc gacgccggac ttcttcgggt
    15421 tcgcacggtt cctcgccggt ctcgggctcg gcggcgtcgt acccaccgcc atcgcgctga
    15481 ccatcgagta cgcgcacccc aggcaccgca gccgcaccaa cggcctgatg ttctcgggct
    15541 attccgtcgg cggcatcctg gccgcgctca cggcgatcgt cgtgatcccg cagcttggct
    15601 ggcgcgcgat gttctgggtc ggcgtcgtgc tgggcgtcgt actcctcccg atcgcatggc
    15661 ggctgctgcc cgagtcggcg agcttcctgc tcgcgcgggg ccgcagggac gaagcggaga
    15721 cgctggcccg ccgctaccgc ctcgccctag aggagccgcc cgccgccggg gccgacgccc
    15781 ctcgcgggct gtccacgctg aaggccctgt tcgttccgcg ctacgtggcc ggcacgctgc
    15841 tgttctggct cggcaccgga gtggggctgc tgctggtgta cggactcaac acatggctcg
    15901 cgcagatcat gcgggaggcc ggctatccgc tgggatcggc gctggcgttc ctgctggtgc
    15961 tcaacctcgg cgccatcatc ggtacgccgc tgttcggcgc actcgccgac cgcgtcgggt
    16021 ccaagcccgt gacgctgggc atgttcctca ccgccgcgct gtgcatcttc ctgctgagct
    16081 tcgaactgcc gagcttcctg ctgttcgtgc tggtgggcat cgcgggtgcc tgcacgatcg
    16141 gaacgacgat cctcgtgaac gcctacacgg cgaacttcta tccggcccac atgcgggcca
    16201 ccggtctcgg ctgggcactc ggtgtggggc ggctgggcgc catcctcggt ccgatctacg
    16261 gcgccttcat cctcgcctcg gggtggggac tcgacgcgaa cttctacgcg ttcgcggcgc
    16321 cggccgtgct gggagcggtc tcgatgctgc tgatacccgc gctgcgcaag tagggccggg
    16381 aatcaagggg cgacgctggg ccgcgctgtc gtccggagag aggagagatg cgctggtgat
    16441 cgtcgcggag gccgtcggcc gtacgctcgt ccgtctcggc gccgacaggg cgttcggggt
    16501 ggtcggcagc gggaacttcc acgtcaccga cgcaatggtc gccgcgggcg cccggtatgt
    16561 cgcggcgcgg cacgagagcg gcgcggcggt catggccgac gcctacgcga gggtctccgg
    16621 aaagctcggt gtcgtcacgg tgcatcaggg ctgcggcctg accaacgccc tgaccggcgt
    16681 caccgaagcg gccaagagcc gtaccccgct cgtcgttctc gccgccgaca cccctgcggc
    16741 ggacctgcgt tccaacttcc gtgtcgacca ggacgcgttg gcacacgccg tgggcgcgcg
    16801 ggcggagcgg gtgcacggag cggacaccgc ggtcgccgac acggtgcggg cctgccggct
    16861 ggcggtctcg ggtcggcgga ccgtcgtgct gaacctcccc atcgacgtgc agagccggca
    16921 ggttcccgaa ccgctgccgg aacccgatcc actccggctg caccggccgg cacccgcgcc
    16981 ggaggccgtg gccgaactcg cccggctgct ggggcagtcg cgccgtcccg tcttcatcgc
    17041 gggtcgcggt gcgctcccca ggccctgcgc ggaggaggcg gaggagaggt ccgccgcgga
    17101 cgcgctgcgt gaactcggcg ccgccacggg cgcgttgctc gcgacctcgg ccgtcgcgcg
    17161 cggtctgttc cacggcgatc cctggtccct cgatgtctcg ggcggcttct cgtcgccctt
    17221 ggcggccgag ctgatctcgg aagcgaacct tgtcgtcggc tgggggtgcg ccctcaacaa
    17281 gtggacgacg cgccacggtt cgctgatcgc ggcggacgcg tccctggtgc aggtggacgt
    17341 cgaggccgag gcgatcgggg cacaccgccc cgtcgacctc ggcatcgtgg gcgacaccgc
    17401 ggcgacggcc tcggcggtga cggcgttgct cgccggcgac gaacgctccc ctgcgcgggg
    17461 ccagttgcag aacggccgac ggggttaccg gtcgcccgag gtgggagcac gcatcgagcg
    17521 cgaactcgcc tggaacaccg tgccctacac ggacgattcg acgggcgaga acatcgatcc
    17581 gcgcacgctg tccatccggc tcgaccaact gctgccgcgc gagcgcgttc tcgccgtcga
    17641 ttcgggcaac ttcatgggct atccggccat gttcctgtcc gtgccggacg agcggggttt
    17701 ctgcttcacg caggcgttcc agtcgatcgg gctcggcctg gccaccgcca tcggagccgc
    17761 ccttgcccgg ccggaccgcc ttccggtggc cgcgctcggg gacggcggtg cgctcatggg
    17821 cgtctcggag ctggagacgg tggtcaggct gggtctgccc atggcggtcg tcgtctacaa
    17881 cgaccgcgcc tacggcgccg aggtgcacca cttcgccggc gacggcgtcg acctgagcac
    17941 cgtgaccttc cccgacaccg acatcgccgc gctcgcccgc ggcctcggct acaccgccgt
    18001 gacggtgcgc ggcgaaggcg acctggagcc cgtcgccgca tgggtggacg ggccgcgcag
    18061 cacgccgctc ctggtcgacg ccaagatcac atcgacggag ggctcctggt ggctgaagga
    18121 ggccttccgc gggcactgac gtgttccgac ggcccgaccg gacgccctgc cccgacaccg
    18181 aacctgacgt gtgccgtcgt cgccgaccgt ccgcggccgg gccctgcggt ctcgcaccgg
    18241 acgtggctcc tcatcgcggc atgatgcact ggcagtgcac cgatgacgtg accgctgtga
    18301 ccggcgacga ccaatggggg gcctgtgcgg gaatatctac tgacgctgtg cgtcacggct
    18361 gccgtcacgt acctgctcac cgccccggtg cgtaagttcg ccatcctcat cgacgccatg
    18421 ccgcagatcc gtgcacgtga cgtgcatcgt gaacccactc cgcgactggg cgggatcgcg
    18481 atgttcggag ggctgtgcgc gggactcctc gtggccggcc aattgacgaa cattcacgag
    18541 gtcttcgaga cgacgagcga gccgctggca ctcctctccg gcgcttccgt ggtcgggctg
    18601 ctcggcgtgc tggacgacaa gtggggcctc agcgcgctgc tcaagctcgg tggccaggtg
    18661 atcgccgcag gggtgatggt cctgcaaggg ctgacggtcc tgtggctgcc gattcccggg
    18721 gtcggcccag tcccgctgtc ggaggaacag gggatgttcc tcaccgtgac ggtggtcatc
    18781 gtcacgatca acgccgtgaa cttcgtggac ggcctggacg gactcgcctc cggcatcgtg
    18841 tgcatagcgg caatggcctt cttcatgcac gcctaccgca tgtggtacgg ctacggcatc
    18901 gaaggggccg ctcccgcaac gctgttcgcg gccgtcctga tcggcatgtg cctgggattc
    18961 ctgccgcaca acatccatcc ggcacggata ttcatgggtg actcggggtc gatgctcatc
    19021 gggctggtga tcgccgcgag cgcggtgtcc gtgaccggcc aggtcgactc ggaccttctc
    19081 gtcgagaggg cgggcagctc ccgcgaagcc acgcacgcga tgatgccggt ctacattccg
    19141 ctgctgctgc cgctgacggt catcgccctc ccggtcgcgg atctgcttct ggcgatcgtg
    19201 cgccgcgtct ggaaggggag gtcgcccttc gccgccgacc gcggccatct gcaccaccgg
    19261 ctgctggaca tcgggcactc gcaccgccgc gccgtcttcg tcctgtactt ctggtccgcg
    19321 ctgatcgcct tcggaacgat cgcgctctcc gtgcacgacg gaagcgtgtg ggtcgcggcc
    19381 ggcatcgtcc ccttcggctt ggtgggcctc gtcctgttgc tgctgccccg cctggcgcca
    19441 cgccgggctc ggcgtccggg aacagcaggg agcactcccc gaacgcagga cgcgtacgac
    19501 gccgaacgcc gcgagctcag cgggacggcc gagggcggac cgcatcagcc gtgacgtgag
    19561 gactgccgca ggtcatcgcc ggatgatctc tggctgacat ccgcccttgt gcacgggctt
    19621 cgtcccgatg aatcatgatc agcgatgccc gccaatacgc tgcagcttcc gaccgatgac
    19681 ggacaggccg acgctttcgc cgccttcccc gagcccggcc aacggcaccc gggagccgca
    19741 ggtgtccgct acagctccga ggtctacccc ggcaccatcc acggcttcac catgtccgac
    19801 accgacacgt tcgacgcctc ggcgctgcag cgccattggg accgcctgct tcccctcctc
    19861 gaccgcaccc tgaacaacgc ctgagcctcc ggcgggagtt cagcgccatc gaacgttcag
    19921 gcgctcgggg agccgactcg gctctcccga cttgccgggc gagccggaat tcgtcggctt
    19981 cacggatgag ttcctgagag cggaaccggt gcaactcgaa gcagttcgtc ctccgcctgc
    20041 acccgtgtca acgcacgccg cgaagggcgc gccgttgaag ctgcgccatc ttgcagcgga
    20101 tgaggtcatt ttcggcgcgg tacggctccg tcctgccagc ggtagaggtc gcgcagcagg
    20161 gaaatctcgg cgccgtgatg gatcagctcc ctgttgacgt gcaggacgat gccctccatg
    20221 ggaaaccgct cgggacccac cgtgggcgga ttgtccaggt cagcgtccga cagttcgcgg
    20281 acccccgcgt tccatctccc atacatctca tcgagctgtt ccagcgcctc gtcagcggtc
    20341 cccgcgtagg cgaatgtctg ggagtcgacg tcctggccgc cgaagtgcca tccgacccgg
    20401 tagcccaggc aggagacgat gatgtgcgcc agccgccagg caatcgtggt caccggcgcc
    20461 ggcaccgggt caggggacgc ggagtccatc gtccacttcc ccgaacctgc cgacatcggt
    20521 gcggccgacg tgccacgtgg ccggatgctc cagcagccac gcacgggctc ccagaagtac
    20581 tcctcatcgg caagaccgtg cagccgcggc cgcaggttct tgtgccagtg ccggtccagt
    20641 tggtccgcga ttcgctcgct tcttgtcact tccgcacact acatacgacg gagacctggc
    20701 tgcgcccctc gcgcaatgac ccaaatgtga cagctcgccc cgggctcccg ggatgcgtca
    20761 gtccacgcgg cagtcgtcca cgtccacccg ggtcatcgcc ttgggatagc ggcgggcgaa
    20821 gtcgacgtag acatccaccc cgtggtcgac ccggcccttg agccggtcgt ccggcagggg
    20881 cttcacccgg cccgggaccc ccagcaccat cgagtgttcg ggcacgtcga gcccttcggg
    20941 tacgagtgcc gcggcggcga cgaccgaacc ggtgcccacg acggccctgt tgagcaccgt
    21001 cgacatggac gcgatcaggc agcggtctgc gaccgtgcag ccctcaaggt gggcgttgtg
    21061 cccgacgacg cactcgtccc cgatgatggt gggccactcc ttcgtcgtgt ggatgatggt
    21121 gccgtcctgg atcgacgtcc gtgccccgac ctcgatccgg ccgtggtcgc cccgcagaac
    21181 ggcacccggc cacaccgacg actcggggcc caggctgacg tgcccgatca gcaccgcgtc
    21241 ggggtggacg taggcgtcgg cactcacccg cggacgtact ccgtcgaacg cgtagacagg
    21301 catgcgtcac tccctttcgg ggtcgaggcc gtggtagacg cgcatggcgt tctcccccag
    21361 cacaagcggc accgtctcgt cggagaaccc cagcccggca gcagcccgag cgttcacggc
    21421 ggttccgggg acaccgggcc agtcggtgcc gaagatccac ttgcgcgcga gcctgttcag
    21481 atcatggcgt gcgtaatacg tcgtcaggcg cttggggggc agtccggaca gttcgatcca
    21541 gacgttctcg ttcgagagcg cgaggaacgc cgcggcgtcg taccaccagc cccggccccc
    21601 gtgtgcgagg acgaccttga gatcggggaa catcctgagc accgggtaga gctgcgtcgg
    21661 gtccgcgttc tcgttcatcg accccgggaa ggacgacgtc ccgcagtgca tcacgagcgg
    21721 gacgttccgc tcgacgagca ccgagtacgc cggaaacagc gcgggatcgt ccaggcggaa
    21781 cccaccgtgc acggggtgca gtttgagcgc ggccgcaccc aggtcgagct gccgccgcag
    21841 ctcccggtcg accgggaagt gcagatgcgg gttgacgttc gcgacgggac ggaagcgccg
    21901 cgggttctgc tcgatgagcg gcagcaggtc gtcgaagtgc tggtagcccg tggccttcgg
    21961 gctgtactcg cagaacagca gcgccacatc gacgccttcg gcg
//
