LOCUS       NZ_CP048882            26243 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces bathyalis strain ASO4wet chromosome, complete genome.
ACCESSION   NZ_CP048882
VERSION     NZ_CP048882.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces bathyalis
  ORGANISM  Streptomyces bathyalis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Rohde,M., Schumann,P., Hahnke,R.L.,
            Sproer,C., Bunk,B., Kampfer,P., Schupp,P.J. and Wink,J.
  TITLE     Streptomyces bathyalis sp. nov., an actinobacterium isolated from
            the sponge in a deep sea
  JOURNAL   Antonie Van Leeuwenhoek 114 (4), 425-435 (2021)
   PUBMED   33595745
REFERENCE   2  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Schupp,P. and Wink,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2020) Microbial Strain Collection, Helmholtz
            Centre for Infection Research, Inhoffenstrasse 7, Braunschweig,
            Niedersachsen 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-FEB-2019
            Assembly Method                   :: HGAP v. v3
            Assembly Name :: Streptomyces_DSM106605_HGAP3_1SC_10M
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 117.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015910445.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 04:35:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,467
            CDSs (total)                      :: 6,387
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 37 of 111
            Pseudo Genes (incomplete)         :: 90 of 111
            Pseudo Genes (internal stop)      :: 12 of 111
            Pseudo Genes (multiple problems)  :: 25 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 106835
            Orig. end                         :: 133078
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048882.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MISG, Helmholtz Centre for
            Infection Research, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26243
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26243
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26243
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16243](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16243)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    127..142
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.03"
                     /tool="antismash"
     gene            134..904
                     /locus_tag="G4Z16_RS00475"
                     /old_locus_tag="G4Z16_00475"
     CDS             134..904
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609683.1"
                     /locus_tag="G4Z16_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00475"
                     /product="response regulator transcription factor"
                     /protein_id="WP_197348615.1"
                     /transl_table=11
                     /translation="MRTQPSAAARRVLVVDDDPTVTEVVAGYLDRSGFVVDRAADGLDA
                     LSRAQAAPPDLVVLDLMLPGLDGLQVCRQLRRQGPVPVVMLTARGDEEDRILGLEVGAD
                     DYVTKPFSPRELVLRVESVLRRAGSPPPEGPLLTGGGITLDPAARSVSDARGALSLTLR
                     EFDLLAHFLRHPGRAFSREQLMADVWGWDFGDLSTVTVHVRRLRHKVEADPAHPRLITT
                     VWGVGYRFDDGGGGGPAAGDAGAGGVGAGGGRDA"
     gene            897..2171
                     /locus_tag="G4Z16_RS32210"
     CDS             897..2171
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140038.1"
                     /locus_tag="G4Z16_RS32210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_246530585.1"
                     /transl_table=11
                     /translation="MRDLLLIALYAALGAAAVGLAGLVALRALRRRSVAVSLAVLTAVA
                     VGSVLAGTLSVAWAMLLNKHDLGVVTTVCVMAGVTATATALWLGRWVIGGHRALERAAR
                     ALGETGGSGAAAGNGGTAGGGGGEADRTALGAASPGGEDGGQSAAGGLLPSGADGAGQA
                     VGGFVQPTTPMPAELTSLSRQLADTSARLALSRERERALEASRRELVAWISHDLRSPLA
                     GLRAMAEALEDGIAEDPARYHRQIRGEVERLSGMVGDLFELSRIQAGSLALSRTRISAY
                     DLVSDALAGADALASELGVRLAAAGVEQIPMEVDGKEMSRVLANLLVNAIRRTPADGTV
                     AVSARQVEDSVVLSVVDGCGGIPAEDLPRVFDTGWRGTDARTPPGGAGLGLAIVRGIVE
                     AHKGQAAVRNVPGGCRFDVMLPAAR"
     gene            complement(2346..3368)
                     /locus_tag="G4Z16_RS00485"
                     /old_locus_tag="G4Z16_00485"
     CDS             complement(2346..3368)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (45-244). E-value:
                     1.9e-09. Score: 28.9. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS00485_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643495.1"
                     /locus_tag="G4Z16_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00485"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_197348616.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.3e-05, bitscore:
                     22.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLVTGGSGFIGSHIVTVLEAVGHEPVVFDRAATDGLRGDVRDA
                     DAVREALRGVDAVCHQSAMVGLGKGFADASAYVSSNDLGTAVLLEQMADAGVHRLALAG
                     SMVVYGEGRYSCPVHGVVRPGPRSVPDLDSGRFEPPCPRCGAALAPELVDEDAPADPRN
                     VYATTKLAQEHLSAAWARATGGRAVSLRYHNVYGDGMPRDTPYAGVASFFRSALERGEA
                     PRVYEDGSQRRDFVHVDDVAAANVVALEALDELPVGGLRAYNTGSGQPHTVGEMADALA
                     EAFGGPKPVVTGEYRLGDVRHITASSERFRRELGWSAHVPFAEGMARFAKDQLAAPARP
                     "
     aSDomain        complement(2637..3233)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS00485_NAD_binding_4.1"
                     /evalue="1.90E-09"
                     /label="G4Z16_RS00485_NAD_binding_4.1"
                     /locus_tag="G4Z16_RS00485"
                     /protein_end="244"
                     /protein_start="45"
                     /score="28.9"
                     /tool="antismash"
                     /translation="DAVREALRGVDAVCHQSAMVGLGKGFADASAYVSSNDLGTAVLLE
                     QMADAGVHRLALAGSMVVYGEGRYSCPVHGVVRPGPRSVPDLDSGRFEPPCPRCGAALA
                     PELVDEDAPADPRNVYATTKLAQEHLSAAWARATGGRAVSLRYHNVYGDGMPRDTPYAG
                     VASFFRSALERGEAPRVYEDGSQRRDFVHVDDVAAA"
     gene            3540..4814
                     /locus_tag="G4Z16_RS00490"
                     /old_locus_tag="G4Z16_00490"
     CDS             3540..4814
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018562382.1"
                     /locus_tag="G4Z16_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00490"
                     /product="4-hydroxybenzoate 3-monooxygenase"
                     /protein_id="WP_197348617.1"
                     /transl_table=11
                     /translation="MTQGSTGGPAAHVPEETTVGIIGGGPAGLLLSRLLHRSGISSVVL
                     ESRDRSYAEQRQRAGMLEQTTVDVLRDCGAGARMDREGLVHDGIELRFDGRSQHIDFPT
                     LAGGRRVTIYAQTEIVKDLISLQLSELSNGAPLLFDAEVHSVSGLTQGGEQATQETGSD
                     SERPVLHYTYEGRRRTLRCDFVVGCDGSHGISRSALPASVARTYEREYPYSWLGILAEA
                     PPSCDELIYAHSPRGFALHSMRSPSVSRLYLQVPNGTDPGEWPDERIWDELDARFALSD
                     DQEWRINRGPITSKAVLPMRSSVTEPMRHGRLFLAGDAAHIVPPTGAKGLNLAVADVAV
                     LARALDRYCTSGDTAALDSYSDDRLRRVWRAEHFSYFMTTTLHTSPDQSPFDTRLQLSQ
                     LDRIASSRAAATELAENYAGLALVD"
     gene            complement(4858..5538)
                     /locus_tag="G4Z16_RS00495"
                     /old_locus_tag="G4Z16_00495"
     CDS             complement(4858..5538)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025017.4"
                     /locus_tag="G4Z16_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00495"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_343070929.1"
                     /transl_table=11
                     /translation="MHWCPFGFHWHRPIQQCANSPMVCSGCCSVFRREVLVDFGGFPER
                     TIVEDMDFTWSQQIAGRRARYVGDAVALAADPETLLYMRKQVWRWMAGFCQNVRLHTGQ
                     LLRRKPILAVWVLLAILEILTAPLWWSAPFVLTLGIGRPALPTVLWWLGAELAFTLPPL
                     VYAARRRQLPLGRVLLNIPCVYPAKVVNLLYAWKAVVVELVLVPLRLSHGLIVYEKGRG
                     SAVA"
     misc_feature    5613..5627
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(5663..6559)
                     /locus_tag="G4Z16_RS00500"
                     /old_locus_tag="G4Z16_00500"
     CDS             complement(5663..6559)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131922.1"
                     /locus_tag="G4Z16_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00500"
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_246530586.1"
                     /transl_table=11
                     /translation="MTFEEYSEEWRGRQREILEYSTGAGHKSHLRVHLYPELGSRKLET
                     FDSMVLERFIATMERNGVKLGTQRNVYGTLHAILLDAFRKGGIPEDPTLGVQPPKYVPD
                     RAVVPDQDYIRLAMRKADFQLAILVTMMYGCGLRNGEARAVNINNIVADDVYRVTEQIH
                     HDTYTPAPLKHRKEGEFREVPLPWSVKLAIERFVDEYGMSDDGYLLRGPRGYFTFRMES
                     NRAGMLFKQAPPPEGMTLYGFRHFFASNCLSRGIPITDVAEWMGHRNIQVTYRTYRHLM
                     PGSISKAAKVLEQGLAA"
     gene            6735..6998
                     /locus_tag="G4Z16_RS32215"
     CDS             6735..6998
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS32215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_246530587.1"
                     /transl_table=11
                     /translation="MEQEQFLKKLPMPLARLLATILPISHLLLFKPLQDISAPEPQLRT
                     FTTPELVSNEPKLWGITVNPSKGHIQHFGGLPSRQHLLRHHS"
     misc_feature    6748..6761
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.51"
                     /tool="antismash"
     misc_feature    6753..6755
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(7121..7134)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    7269..7283
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.2"
                     /tool="antismash"
     gene            7584..7775
                     /locus_tag="G4Z16_RS00510"
                     /old_locus_tag="G4Z16_00510"
     CDS             7584..7775
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS00510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_00510"
                     /product="hypothetical protein"
                     /protein_id="WP_197348620.1"
                     /transl_table=11
                     /translation="MDGAQLVERVELGVSWIIRNLDAVSAVGLGLTIDFLDVFGRVVSD
                     DVSSGATLLVLGAPAVGR"
     gene            complement(7950..8594)
                     /locus_tag="G4Z16_RS00515"
                     /old_locus_tag="G4Z16_00515"
     CDS             complement(7950..8594)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559358.1"
                     /locus_tag="G4Z16_RS00515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00515"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_197348621.1"
                     /transl_table=11
                     /translation="MGDWAGRTEEVQREVGTRHMGKEEARRVLLRRTYDAAVEDVWDAC
                     TDRERVSRWFVPVSGELKPGGHFRLEGHAHGEILRCEAPELLKLSWLFGDDPDFGEVEL
                     RLMAEGEERTVLELEHVAAVPEEVWDHFGPGAAGLVWDLTALGLHFHLLGGPVGDLAAW
                     RESDEAREFMTRSSEAWGAAYEASGAPADVAAPAVTNTTAFYAPRREDGDR"
     gene            complement(8792..9904)
                     /locus_tag="G4Z16_RS00520"
                     /old_locus_tag="G4Z16_00520"
     CDS             complement(8792..9904)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953653.1"
                     /locus_tag="G4Z16_RS00520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00520"
                     /product="hypothetical protein"
                     /protein_id="WP_197348622.1"
                     /transl_table=11
                     /translation="MDPHGPIAQRFPLVARFRPACLPLPERIASITDLADTAVSESDQG
                     VASSVYNQAALVASDLGRPDLAREMCQQHAAAHLHACPLPGMSAIRALEPAVNLARLQV
                     RAGCGDEGRRRLLALHSAVGAGTAARFEDIAIPASLTATADDRQEVHAWLWRVLLADGT
                     RTLTTEGRWEEALAHIEQHRGIGTRMLDGRQVAVLAALTTGDTARARNLLDQTTPGDPW
                     EQRVSACLTVLCRLAVGESTGQHVADLADVYLDAPAGHGTTVFDMRLGLTILAAARSAG
                     HAVAHDLVDSLHRRTTEARDGYAAREALADTQFTDLASDQQVHECHELLHMCALGSGHL
                     PDDLLSDLLSAIRTGDRVIREGHPALHGGR"
     misc_feature    complement(9908..9924)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.65"
                     /tool="antismash"
     misc_feature    complement(9909..9924)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.11"
                     /tool="antismash"
     gene            complement(10001..12079)
                     /gene="fxlM"
                     /locus_tag="G4Z16_RS00525"
                     /old_locus_tag="G4Z16_00525"
     CDS             complement(10001..12079)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543781.1"
                     /locus_tag="G4Z16_RS00525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00525"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_197348623.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.4e-29, bitscore:
                     100.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 4.4e-45, bitscore: 152.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDRWHQHNVVFPNREIAQSAIPERIAPALLAAEEAGEITGWWF
                     MNKQPWPLRYRAPEASPTVQRLLSDLVADGTVRSWLSGIYEPETFALGGQWAIDAAHSL
                     FHLDSRHLLTYRPGPGHLGRRETAVLLASAMMRAAGLDWYEQGDVWAKYADLRRAPEPI
                     APEQRAALAPAMRTLMTANTADLTRPGGPLDGHAEWVSAFERTGTGLAGLATQDGLTRG
                     LRAVLAHHVLFHANRAGLSPEDQHALSHVAREVVMESHDNTSAAGTHATADSVSAVNTD
                     TTTTPEADAEQLRNALVDQIKANGRARTPEVETALRTVPRHLFVPNAALEAAYANTVVD
                     VKHDNDGTSISCASQPVIVALMLDRLEAQPGERILELGAGTGYNAALLGHLVGEHGHIT
                     TIDVDDDLVEGARQHLAAADITNVTALTRDGAVGHAEGAPYDRIIATVGAHGIPHAWLD
                     QLAPGGRLVAPQRLKGSVSRSIAYEKHDGRWTSVGSEMNTFMPLRKGIADDDRRDVPLS
                     ADGAVRLHAPSAQHIDADALAGALEQPRVEEWTGMTVRAMESPEWMELYVSCSMPSGLI
                     RMLFPKTAKGTLLTDDPYPSSTAAVEKGALTYLARRVSKQTTADGGKLWEFGVIGHGPG
                     SDELVAQVADAVRTWDREYRGREATFELQDLTAPRVEPRPGLFSLDTPLNRVVVDFN"
     gene            complement(12102..13331)
                     /locus_tag="G4Z16_RS00530"
                     /old_locus_tag="G4Z16_00530"
     CDS             complement(12102..13331)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543780.1"
                     /locus_tag="G4Z16_RS00530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00530"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_197348624.1"
                     /sec_met_domain="LANC_like (E-value: 9.4e-43, bitscore:
                     144.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSEALSAAIADSLADPDARPLVLEDRQHLAYGMPGIALLHIER
                     AAAGLAPWSRAHDWLFSAARQPVTSGPDSHPFYGAPALAHAVACAADHQPGSYERALTK
                     LDEQMVRDVRRRLSAAHRRLDAGQLPQFAEFDVIRGLTGYGSYLLRRQPAGGALRDVLD
                     YCVRLTRPITDRGERLPGWWAPTAPMGRLDDQFPEGHANHGMSHGVGGVLALLALAARH
                     GTVVDGQHDAMRTILAWLSRWHGQAWPYWVTRAELRADSLAPSAPRRPSWCYGTAGVAR
                     AQQLAALALNEAPRQVEAETALVAALTDPAQLRATTDNGLCHGFAGLAHVASRAADDAH
                     PSTAAQLRDAIPALLSTVCPPDTDPVDAAVANEAGPGFLDGAAGIALAVLAPATGTPPH
                     TAWDSCLLIA"
     gene            complement(13328..16243)
                     /locus_tag="G4Z16_RS00535"
                     /old_locus_tag="G4Z16_00535"
     CDS             complement(13328..16243)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014628008.1"
                     /locus_tag="G4Z16_RS00535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00535"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_246530588.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.8e-189,
                     bitscore: 627.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.3e-17,
                     bitscore: 60.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.4e-25, bitscore:
                     86.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEGLRHASPVLAASVESLCSAAVPEARQLHKTVLSVARYLLRAQ
                     HRPSPFGLFAGVTAATFAPRARAEWGGRHAVTARAGAEWLSAVIARLEKCPDLLERLPV
                     VVNTAVTTRGDRLIVPYEPDADDGQARAVEVSLASTAPVRSVLAAARAPLPTGALADKL
                     CAEFPTAGRETVQNLIGQLLARRVLITSLHAPSTETDALTYLLARLDDVDADGLAPVAE
                     TMRELRAIRAGLDVYGVRDGRDRVATRMRALTPELRRHPLALDVRLDVQLALPEAVARE
                     VERAAWVLTRVCARPYGTEAWRTYHQRFYERYGIGTMVPLRDVLADSGTGFPDGYPGAP
                     SGAGRARLSARDDALLRIAQAAALEGGTEVALTDELLAELDIGPEQPRIPPHLEVGVRV
                     DASSLDDLQRGRFRLEVGSVSRGAGVSTGRFLSVLAPDDRKALIAELADVPAADEDTVP
                     AQLSFPPLLPASTHVTRAPRIHPTVISVQEHRTPDGADVLTPDNLAVACDGRRMYLADP
                     GRGRRIEAVGLHALNLRTHTPPLVRFLTELSRAQCAQVTTFDWGAASALPFLPRLRYGR
                     TVLAPARWLLDAAELPPHNWDAALTDWRERRHAPRRVLLVEDDRRLFLDLDDAGHRTLL
                     RAHLDRAGTAHLQEAPEQDAYGWCDGRAHEVVVPLKATRPATWPRLPAPTLARTFSPEQ
                     QQTPAAAPVLLAALYGDARRQDELLARYLRELLGRLGDPPWWFIRFRDPDPHVRLRIGL
                     PSPDAFAATARTVSAWADELRAAGLLSDLRYPTSYREMGRWGSGPAWEAAEDVFRADSR
                     AILAQLRQPQRPPQRALVAAHTVAIAAGFLGGVEAGMRWLIDHIPATAPNQVPRPQFTE
                     AVRLADPTDDWAALRSKPGGTAIAAAWVDRVAALATYRPHLLGPHTDGIALDDVLTSLL
                     HTHFVRHVAVNFPEEEICLYLARAAALAWTARAEKQMGTQP"
     aSDomain        complement(15659..15934)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_G4Z16_RS00535_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.60E-19"
                     /identifier="RREFam001.1"
                     /label="G4Z16_RS00535"
                     /locus_tag="G4Z16_RS00535"
                     /protein_end="195"
                     /protein_start="103"
                     /score="60.2"
                     /tool="antismash"
                     /translation="VVVNTAVTTRGDRLIVPYEPDADDGQARAVEVSLASTAPVRSVLA
                     AARAPLPTGALADKLCAEFPTAGRETVQNLIGQLLARRVLITSLHAP"
     gene            complement(16494..16682)
                     /locus_tag="G4Z16_RS00540"
                     /old_locus_tag="G4Z16_00540"
     CDS             complement(16494..16682)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031313.1"
                     /locus_tag="G4Z16_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00540"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_246530589.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.5e-11, bitscore:
                     41.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPSISTTSDETQVNPPKVQAGVPDGFQLDVALVEVADTAGLVSI
                     TNDGCGSTCGACTTNVA"
     CDS_motif       complement(16563..16682)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSPSISTTSDETQVNPPKVQAGVPDGFQLDVALVEVADTA"
                     /locus_tag="G4Z16_RS00540_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16494..16562)
                     /prepeptide="core"
                     /locus_tag="G4Z16_RS00540_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-7.10"
                     /molecular_weight="1936.1"
                     /monoisotopic_mass="1934.9"
                     /core_sequence="GLVSITNDGCGSTCGACTTNVA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSPSISTTSDETQVNPPKVQAGVPDGFQLDVALVEVADTA"
                     /leader_location="[16562:16682](-)"
                     /alternative_weights="1954.1"
                     /alternative_weights="1972.2"
                     /alternative_weights="1990.2"
     gene            complement(16884..17417)
                     /locus_tag="G4Z16_RS00545"
                     /old_locus_tag="G4Z16_00545"
     CDS             complement(16884..17417)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS00545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_00545"
                     /product="hypothetical protein"
                     /protein_id="WP_197348626.1"
                     /transl_table=11
                     /translation="MPAEMLRVGPSEIRRGDRTLRGGTQVEVIDMLVAGLTGKMLRFDN
                     GSTYLLRSGDELQVWRGAEDAAPARRVIPAGRTAADVAAAQAWNSTRQLGERAERHSQA
                     AIEMWARRRRRFAAARAQRSEQSGPRGPYPGEEQMLHCGNRMRPQPVQGGGVLYTCNRC
                     GHLSTGSGDPPHPQ"
     gene            complement(17917..18321)
                     /locus_tag="G4Z16_RS00550"
                     /old_locus_tag="G4Z16_00550"
     CDS             complement(17917..18321)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716396.1"
                     /locus_tag="G4Z16_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00550"
                     /product="ATP-binding protein"
                     /protein_id="WP_343070582.1"
                     /transl_table=11
                     /translation="MTESSATGVPSYSETLPRVPESVAKARRLVSSSLRVWHLEGAEDT
                     ARLVVSELVTNTVAHTRLDCVRVTISRVDEHLVRVAVTDRSQNMPEGREAGLDDESGRG
                     LALVDALSTDWGVDPLRWGKRVWADVKCGA"
     misc_feature    complement(18505..18520)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            18644..19894
                     /locus_tag="G4Z16_RS00555"
                     /old_locus_tag="G4Z16_00555"
     CDS             18644..19894
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716397.1"
                     /locus_tag="G4Z16_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00555"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_246530590.1"
                     /transl_table=11
                     /translation="MYANAKLEARIEQLGFSQAALAREINLAVERLTGSYGSVTDADVR
                     RWLRYETRWPQDRIRLCIEEVLDASSEDLGFIPRRKDSRAPSEDGPVQRRAFVNAVGGA
                     GLGFATPQARQRRLGVSDVDRFHEDYVKILQEDRVVGGTRRVENLAIELGTRVQSALAT
                     GVATSRVRDMLHRLAAEAMSAAAFAALDASSPKRARAHLDKAMTLAGLSRDSQTTYRVW
                     DHLMLASSMRENHAEAAASADVMKRSTAARRDPLFASLGHMRNANALARLDQHTDALRA
                     LALAEKNFSRSQSARSEWISFYGAAEFDALSSYVWTAVGEHGRAEFCLHRTLAAIPEDM
                     ARDRALFTAHLSLAQVRQGELEVGCATARKASALLHPGSGSRRTAKTLARGRELLIASG
                     SKAPEVTEWTEESRRWI"
     misc_feature    18863..18865
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19885..20406
                     /locus_tag="G4Z16_RS00560"
                     /old_locus_tag="G4Z16_00560"
     CDS             19885..20406
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179465.1"
                     /locus_tag="G4Z16_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00560"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_197348628.1"
                     /transl_table=11
                     /translation="MDLRRYDHADAQDVRSMLLDIHDEVYSDDPDPFHSRERFTYFLDL
                     WSSRKNWRCVSGWENGGPVGFAYGSVLAPGGWWQGSTRPLGLRGPVFALSELMVLPKWR
                     GTGRAKKIHDALLAPVDARVVSLQVEIAHEKVVRLYESWGYRKVDEAKSHDDSPQYAVM
                     LADLPLNRCR"
     gene            20426..20698
                     /locus_tag="G4Z16_RS00565"
                     /old_locus_tag="G4Z16_00565"
     CDS             20426..20698
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_00565"
                     /product="hypothetical protein"
                     /protein_id="WP_197348629.1"
                     /transl_table=11
                     /translation="MTPPPFEPPATHARDAINSSIRSLMSQPQHHRRGEEYARLLALWS
                     DVGLANTVKAPHQGSEDGEASCHQSQQVATCMDESQNTAYADMSI"
     gene            complement(<21108..>21365)
                     /locus_tag="G4Z16_RS00575"
                     /old_locus_tag="G4Z16_00570"
                     /pseudo=""
     CDS             complement(<21108..21365)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1151: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_195211954.1"
                     /locus_tag="G4Z16_RS00575"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="G4Z16_00570"
                     /product="ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRVDLLCIDELGYMELDKHGAELLFQVLTEREEKNSVAIASNES
                     FGGWTKIFTDPRLCAAIVDRLTFNGTIIETGTDSYRLANSR"
     gene            21942..22328
                     /locus_tag="G4Z16_RS00580"
                     /old_locus_tag="G4Z16_00575"
     CDS             21942..22328
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019546446.1"
                     /locus_tag="G4Z16_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_00575"
                     /product="hypothetical protein"
                     /protein_id="WP_197348630.1"
                     /transl_table=11
                     /translation="MSVYQVSCPARTLILDEERRLLEEGGLRIEPTLWCTLEAEHGGLH
                     LTLAQALKGGGGVPPSTLWLRWPEDAEHGPLRELLTLPSCPERFLAGTVEEEVCDLPKD
                     HAGRHGFEFGPPLNDGDITPDWLL"
     gene            22494..23255
                     /locus_tag="G4Z16_RS32220"
     CDS             22494..23255
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS32220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_246530591.1"
                     /transl_table=11
                     /translation="MERQFVVGVDERFGVSSVDGAGEVVRTDIGIELLQRPMGRVGSSG
                     ADQLRDKPWAPAFLPVQQDLLPGFLIQQHPSHHIRRGLLGGEHAREGVVELKDFPCSVG
                     EEGHRLQLVYGLPPDVRDGQLGGTQRPWWAVTDCAHPRLAPLILIQLQDFRDALKEFRS
                     RSRSSTAFQLVVRLDAAPKRTGYLTLRQSHCFLTAGVTGSVQPEFGRVDAFPRRGEQAP
                     QTATASIGQAGHRPAPLPDVDSISHECRPGF"
     gene            23508..25271
                     /locus_tag="G4Z16_RS00595"
                     /old_locus_tag="G4Z16_00590"
     CDS             23508..25271
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_00590"
                     /product="hypothetical protein"
                     /protein_id="WP_197348631.1"
                     /transl_table=11
                     /translation="MLLEADPSLPPATQQHRTVRLLAHLVREQATGIVAMNEASQLALL
                     ASGDRLPLFVPRRPCTGLELQSQLLRAQLRAERSAHARTEALLKLASRLDRQGEGPQEV
                     LRMVRQETGATVRIIDVDADEENPSDQEIPPHLLKLVASGQADSATDDTEGHLLLHALG
                     GGYPRPVLAAESTVPWTPAQHAFVATAALHVSLLRQPLALRAQQQRLAETASAMREAAL
                     LALLRGTLAQARLSLKGLGLDLLDHPWMQFGVLRCPAGEDRVNLREECSRLLSRSALVA
                     PCPAEPDDLLILRGLDSAEADTGTAQLLLPLVTARPGRMLGLSQPQPWERTAHVYNSAV
                     NALSQTTPQRPFATDAGAPCISQQLPAWASLWAAGVLKSKLGSLAQEDRESLLEISYRA
                     LTIGTKQTAGLLNTQEQESDPLHRNTVSAQLTRLSGLLGLGSSRRDRALLHFLLDVASH
                     APQSAAIAGGPKNPTLSDVLATPEARSAAHQVIAPLETRQNTYLLKTLIVRATSDSVDE
                     AADTLGITRRALQKRLTIIGTTIGRQMSGPPWGWLHEVILALVIAGHVSQDLLTDPSLP
                     SAPASRHDPAA"
     misc_feature    complement(25402..25415)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
ORIGIN
        1 catctccatc tgcctcaccc tacgagccca taacggacat aagggatcga cccaccttac
       61 ggaaggctga catccgtgcc cgggcgacgc ctcgacaggg ccaccgcgcc cggcccggtg
      121 ccagactcgc catatgcgaa cacagccttc ggccgcggcc cgcagggtcc ttgtcgtgga
      181 cgacgatccg accgtcacgg aagtggtggc cggttacctc gaccgctccg ggttcgtcgt
      241 cgaccgcgcg gccgacgggc tcgacgccct gtcccgggct caggccgccc cgcccgatct
      301 cgtcgtgctc gatctgatgc tgccgggact ggacggcctt caggtgtgca ggcagctgcg
      361 ccggcaagga ccggtgccgg tggtcatgct gacggcacgc ggcgacgagg aggaccgcat
      421 cctcggcctc gaggtgggcg cggacgacta cgtcaccaag ccgttctctc cgcgtgaact
      481 ggtgctccgc gtcgagtcgg tgctgcgccg cgcggggtcg ccgccgccgg agggtccgct
      541 gctgacgggt ggcggcatca cactcgaccc ggccgcccgt tccgtctccg acgcacgggg
      601 agctctgtcg ctgacccttc gagagttcga tctgctcgcg cacttcctgc ggcatccggg
      661 gcgggcgttc agccgggagc agctcatggc ggacgtgtgg ggctgggact tcggcgacct
      721 gtcgacggtg accgtccacg tgcggcgtct gcgtcacaag gtcgaggccg atcccgcaca
      781 cccgcggctg atcacgacgg tgtggggtgt cggctaccgc ttcgacgacg gcggtggcgg
      841 tggtccggcc gccggtgacg cgggcgcagg cggcgtcggc gccggtggag gccgtgatgc
      901 gtgatctgct gctcatcgcg ctctacgcgg ccctgggagc ggcggccgtc ggcctggccg
      961 gactggtcgc gctgcgcgct ctgcgacgcc ggtcggttgc cgtgtcgctg gcggtcctca
     1021 ccgctgtcgc ggtcggttcg gtgctggccg ggaccctgtc ggtggcatgg gcgatgcttc
     1081 tcaacaagca cgacctcggc gtggtcacga cggtgtgcgt gatggcgggt gtgaccgcga
     1141 ctgccaccgc cctgtggctc ggccggtggg tgatcggcgg gcaccgagcg ctggagcggg
     1201 cggcgcgcgc tctgggcgag acgggcggct ccggagcagc cgcaggcaac ggcggtacgg
     1261 cgggcggggg cgggggcgaa gcagaccgta ctgcgctggg tgccgcctcc cccggtggcg
     1321 aagacggcgg tcagtctgcg gcggggggtc tgctcccgtc gggggcggat ggggccggtc
     1381 aggccgtcgg cggattcgtg cagccgacca cacccatgcc ggccgaactg acgtcgctct
     1441 cccggcagtt ggcggacacc agcgcaaggc tcgccctctc gcgcgaacgc gagcgcgctc
     1501 tggaggcctc acgccgcgaa ctcgttgcgt ggatctctca cgacctgcgg tcaccgctgg
     1561 ccgggctgcg tgcgatggcc gaggcgctgg aggacggcat cgccgaggac ccggcccgct
     1621 accaccggca gatacgcggg gaagtcgaac ggctctccgg catggtcggc gacctcttcg
     1681 aactctcccg catccaggcc ggttcgctcg ctttgtcccg gactcgtatc tccgcgtacg
     1741 acctcgtcag cgacgccctc gccggcgccg acgccctcgc cagcgagcta ggggttcgcc
     1801 tcgcggccgc cggcgtcgag cagatcccga tggaagtgga cggcaaggag atgtcccgcg
     1861 ttctggccaa cctcctcgtc aatgccattc gccgcacgcc cgcggacggc acggtcgccg
     1921 tctccgcgcg acaggttgag gactcggtgg tgctgtcggt tgtcgacggc tgcggaggca
     1981 tcccggcgga agaccttcca cgggtcttcg acaccggctg gcgcggcacc gacgcccgca
     2041 cgccgcccgg cggcgccggg ctcggactgg caatcgtgcg cggcatcgtc gaggcccaca
     2101 aggggcaggc cgccgtacgc aacgtgcctg gcggctgccg cttcgacgtc atgctcccgg
     2161 ctgcccgctg acctcccccg acgcggacgt cagctcatcg gaccgctccg tacgcgcagt
     2221 tgaccggcga ggcctcggag ccgcaggcgg ctggtcatgg tccacggggc ggtgggcgcg
     2281 ccggacccgt tcgatgcccg cgaccgcccc acgagcacgg atgctgagcg agcccgcggg
     2341 gcttctcagg gtctggcggg ggcggccagt tggtccttcg cgaagcgtgc catcccctcg
     2401 gcgaacggca cgtgcgcgct ccagcccagc tcacggcgga agcgttcgga ggacgcggtg
     2461 atgtgccgta cgtcgcccag gcggtactcc cccgtcacca ccggcttcgg cccgccgaac
     2521 gcctccgcca gcgcatcggc catctccccc acggtgtgcg gctgtccgct cccggtgttg
     2581 tacgcgcgca ggccaccgac cggcagttcg tcgagggcct ccagcgcgac gacgttcgcc
     2641 gccgccacat cgtcgacgtg cacgaagtcg cgccgctgcg aaccgtcctc gtacacccgg
     2701 ggggcctccc cgcgttccag ggctgagcgg aagaacgagg ccacccccgc gtagggggtg
     2761 tcccgcggca ttccgtctcc gtagacgttg tgatagcgaa ggctgacggc ccggcctccg
     2821 gtggcacgcg cccaggcggc cgacagatgc tcctgtgcca gcttcgtcgt ggcgtagacg
     2881 ttgcgggggt cggcgggggc gtcctcgtcg acgagttcgg gggcgagcgc ggctccgcac
     2941 cgcgggcagg ggggctcgaa gcggccgctg tccaggtccg gtacggaccg agggccgggc
     3001 cgcaccaccc cgtgaacagg acagctgtac cgcccctctc cgtacacgac catcgacccg
     3061 gcaagagcca gcctgtgcac tccggcgtcg gccatctgct ccagcagcac tgccgtaccg
     3121 aggtcgttgc tgctcacgta cgcggacgca tccgcgaagc ccttgcccag ccccaccatc
     3181 gccgactggt gacacaccgc gtcgactcct ctgagagcct ccctcacagc atccgcgtcc
     3241 cgtacatctc cgcggagccc gtccgttgct gccctgtcga acaccacggg ctcgtgcccc
     3301 acggcttcga gcaccgtcac gatgtgagac ccgatgaacc ccgaaccgcc tgtcaccagt
     3361 acgcgcatgt cgccacgtta cggctggcgg atccctgacc ggccgaaccg ggaggtatgt
     3421 cagcgttccg taagactggt cagtcgccca cgctgttgag acgatcaccg catgtgcatc
     3481 ctgcgcatcg aagccgcgcc cccgtatccc gcgccggtcc actgcctcgg agaccggcga
     3541 tgacgcaggg ctcgaccggc ggccccgcag ctcacgtccc ggaggagacc accgtcggca
     3601 tcatcggcgg aggcccggcg ggtctgctgc tctcccggct ccttcaccgc tccggcatct
     3661 cgagcgtcgt cctcgaaagt cgtgaccgct cctacgcgga gcaacggcag cgagccggga
     3721 tgctggagca gacgacggtg gacgtgctgc gcgactgcgg cgccggagcg cggatggacc
     3781 gcgaaggcct ggtgcacgac ggcatcgagc ttcgcttcga cggacgctcc cagcacatcg
     3841 acttccccac tctcgcgggc ggccgccgcg tgacgatcta cgcccagacg gaaatcgtca
     3901 aagacctcat ctcccttcag ctctccgaac tctccaacgg cgcacccctg ctcttcgacg
     3961 ccgaagtcca ctcggtctcc ggcctcaccc agggagggga acaggcaacg caggagaccg
     4021 gctcggactc cgagaggccc gtgctgcact acacctacga gggccgccgg cggaccctgc
     4081 gctgcgactt cgtcgtggga tgcgacggct cccacggcat ctcacgcagc gcactccctg
     4141 cctccgtcgc ccgtacctat gagcgcgagt atccgtactc ctggctcggc atcctggccg
     4201 aagcgcctcc ctcctgtgac gagttgatct acgcacactc gccgcgcggt ttcgccctgc
     4261 acagcatgcg ttcgccatcc gtcagccgcc tctatctgca ggtgccgaac ggaaccgatc
     4321 ccggtgagtg gccggacgag cggatctggg acgaactcga cgctcgcttc gccctcagcg
     4381 acgaccagga atggaggatc aaccggggac ccatcacctc caaagcagtg ctgcccatgc
     4441 gcagcagcgt caccgaaccc atgcgacacg ggcggctgtt ccttgcgggc gacgccgccc
     4501 acatcgttcc gcccaccggc gccaaggggc tcaacctcgc tgtcgccgac gtcgccgtgc
     4561 tggcccgtgc gctcgaccgt tactgcacct ccggtgacac tgccgctctc gacagctatt
     4621 ccgacgaccg tcttcgacgg gtctggagag ccgagcactt ctcctacttc atgaccacca
     4681 cgctgcacac ctcccccgat cagtcaccct tcgacacccg gctccagctg tcccaactcg
     4741 accgcatcgc ctcctcacgc gccgccgcca ccgaactcgc tgagaactac gcgggacttg
     4801 ccctggtcga ctaggcgatt cttggactcg gggggtcacg ccgccgacgg cacgggctca
     4861 tgcgaccgcc gatcccctcc ccttctcata gacgatcaga ccgtgcgaga gacgcagcgg
     4921 aacgagcacc agctccacca cgacggcctt ccacgcgtag agcagattca cgaccttggc
     4981 cggatagacg caggggatgt tcaacagcac acgccccagc gggagttggc gtcttcgtgc
     5041 tgcgtacacc agaggcggca gcgtgaaggc cagctccgcg cccagccacc acagcacggt
     5101 gggcagagca gggcgcccta tgccgagcgt caggacgaat ggagcgctcc accagagggg
     5161 cgccgtgagg atctctagta tcgccaacag cacccacact gcgagtatcg gcttcctgcg
     5221 cagcaactgc cctgtgtgca ggcgcacgtt ctggcagaag ccggccatcc accgccacac
     5281 ctgcttgcgc atatagagca gcgtctccgg gtccgcggcc aaagcgaccg cgtcaccgac
     5341 gtagcgcgca cggcgtcccg cgatctgctg ggaccaggtg aagtccatgt cctcgacgat
     5401 cgtccgctcg gggaagccgc cgaagtccac cagcacctct ctgcggaaga ccgagcagca
     5461 accggaacag accatggggc tgttggcaca ctgctggatg ggccggtgcc agtggaagcc
     5521 gaaggggcac caatgcagcc gcgatgcagg tcaggcacta cgtagcggtc ttgggatcag
     5581 cagaaggtca gcatcagcct tggcccagac gtcgatcggc tcggccaccg agtctccgcg
     5641 acgatgtggg acacccctcg actcacgcgg ctaggccttg ctcaagcacc ttggcggcct
     5701 tcgagatcga ccccggcatg aggtgccggt aagtccggta cgtcacctga atgtttcgat
     5761 gccccatcca ctctgccaca tccgtgatag ggataccgcg actgaggcaa ttggaggcga
     5821 agaaatgacg gaacccgtac agggtcatgc cttccggtgg aggcgcctgc ttgaaaagca
     5881 tacccgcacg gttactctcc attctgaagg taaagtaacc cctcggcccg cgcaggagat
     5941 acccatcgtc gctcattcca tactcatcaa caaaacgctc aattgccagc ttgactgacc
     6001 atgggagcgg aacctctcgg aattctcctt ccttgcggtg cttcaagggg gctggcgtgt
     6061 aggtgtcgtg atgaatttgc tccgtcacgc ggtacacgtc atcggcaaca atgttattga
     6121 tgttcacggc acgtgcctca ccgttgcgga gcccgcaccc atacatcatg gtcaccaaga
     6181 tggcgagctg aaagtcagcc ttgcgcatag ccaaccgtat gtaatcttgg tcgggcacga
     6241 cagcacggtc aggaacatac tttggcggct ggaccccaag agtgggatcc tcggggatac
     6301 cccccttcct gaaggcatcc agaagaatag catggagagt tccatacaca ttgcgctgag
     6361 tgccaagctt cacaccattg cgctccatag tggcaatgaa gcgctcgagc accattgaat
     6421 cgaatgtctc caatttcctg gagccaagtt ccgggtacaa atgaaccctc agatgactct
     6481 tgtgcccagc cccagtcgaa tattccagaa tttcacgctg ccggccacgc cactcctcgg
     6541 aatactcctc aaatgtcatc cgcctcaggc gcgaccgagt ctctgccaca gaaactggag
     6601 tcttgcgctt cgcatcatac agcgccgtga gacgatcctt ggcagcatcc tgatttgggt
     6661 acccagtctc ctcgcgctgc ttcccggccc cgtcgcggaa tcgtatagtg tacaggtgag
     6721 cacactttgt cggcttggag caggagcagt tcttaaaaaa gctccccatg cccctcgcga
     6781 gactgctggc caccatactc cccatttcac atcttctgct gttcaagcca cttcaagaca
     6841 tcagcgcacc tgaaccgcaa cttcgcactt ttaccacgcc cgaacttgta tccaatgagc
     6901 ccaagctttg gggcatcacg gtaaatccaa gtaagggaca cattcagcat ttcggcggtc
     6961 tgcctagccg tcagcatctc ctgcgacatc acagctgacg gatattgggt cctattgcta
     7021 gcagtcacca attggatctc ctgaacaggc acggcgcgct ggcagcggct gctgccagcc
     7081 gacctacgcg actccaccgc caagtgcagc aacgcagata gcaaccagcg tgccgagaat
     7141 ccccggtttc gctaaccggg gatcgtcggc tataaaggcc cgttccaacc cgcttgtcac
     7201 cggacctcgt tgcccctgga aggctgggaa ccagcaacca aaccctggag ctggacgccg
     7261 tcgcacccaa tcctcagaag atcgactccc cagccctcct ctgactggcg agccgcgccg
     7321 atgtgtggga tccccttcgc tgacgtggtg gtttcctcgg acgctgtacg ttgacatgct
     7381 tcagcccagt ggttccaatt cctcgagaac tacgccgtct gctgtcagcg aatcgtgggc
     7441 aagtcggcag cacgacggtg gccaggaaga agaagtaacg tcgacgactc tgcgaccttg
     7501 cgggtcgtgc cgaacaccgt tgtcacggaa ccaagttctc gatgcagggc aggccggcca
     7561 gtgcgatgct gatcatcaca gggatggatg gcgcacagct cgtggaacgg gtggagctgg
     7621 gcgtcagctg gatcatccgg aatctggacg ccgtcagcgc cgtcgggctg ggcctgacga
     7681 tcgatttcct ggatgtcttc gggcgcgtgg tcagcgacga cgtctcttcc ggcgcgacac
     7741 tccttgtact cggcgcacct gccgtgggtc ggtgaccgag caggttcctc aaaggccgcg
     7801 caccggtcgg tggccggctg gacgccgggg ctaaggcatc cgcatccggg gggccgcgag
     7861 tcgcgacacc gccgggccgc acggggccca tctcgcttgt gcgaaccggg agttgtgaag
     7921 ggctcccgcg gggtcgtccg tccggcagct cagcggtcgc cgtcctcgcg gcgcggggcg
     7981 tagaaggccg tcgtgttggt gacggcgggc gctgccacgt cggcgggcgc gccggaggcc
     8041 tcgtacgctg cgccccatgc ctcgctgctg cgggtcatga actcacgtgc ctcgtcggac
     8101 tcccgccagg cggccaagtc gccgaccggg ccgcccagaa gatggaagtg gaggccgagc
     8161 gccgtcaggt cccagacgag acctgccgct ccgggcccga agtggtccca cacctcttcg
     8221 ggtacggcgg cgacgtgctc cagctccagt acggttcgct cctcgccctc ggccattagc
     8281 cgcagctcga cctcgccgaa atcggggtcg tcgccgaaca gccagctcag cttgagcagt
     8341 tcgggcgcct cgcagcgcag gatctcgccg tgagcgtggc cctcgagccg gaagtgcccg
     8401 ccgggcttca gttcgccgct gacgggtacg aaccaccgac tgacgcgctc ccggtccgtg
     8461 cacgcgtccc agacgtcctc gacggccgcg tcgtatgtgc gccgaagcaa gaccctacgg
     8521 gcctcctcct tgcccatgtg ccgggtgccg acttcccgtt ggacctcctc ggtcctgccg
     8581 gcccagtcgc ccatcgatgc tctgctcctc actgcgacgg ccgccgcacg gccctcgcgc
     8641 agccaccgac gttaccgctg tccggccggg cccgcgttca aggacgccgg ccccaaggcg
     8701 catgtgcgga tcggcacagt tcatgttggc tcgcagctgt ctttgcccgg cgaactgact
     8761 tagattcagc gccgcctcac ccgaccgtat gtcaccttcc cccgtggagc gccgggtggc
     8821 cttctcggat cacgcggtcg cccgtgcgta tcgccgagag caggtcactg agcagatcgt
     8881 ccggcaagtg gcctgaaccc agcgcgcaca tgtgcagcag ctcgtggcac tcgtgcacct
     8941 gctggtcgct ggcgaggtcg gtgaactgtg tgtcggcaag ggcctcacgg gccgcgtagc
     9001 cgtcgcgggc ttcggtcgtg cggcggtgca ggctgtcgac gagatcgtgg gcgacagcgt
     9061 gaccggcgga tcgggcggca gcaaggatcg tgaggccgag ccgcatgtcg aagacggtcg
     9121 tgccgtggcc ggccggagcg tcgaggtaga catcggccaa gtccgcgacg tgctgcccgg
     9181 tcgactcgcc gacagcgagg cggcacagca ccgttaggca ggcggagact cgctgttccc
     9241 acgggtcgcc gggtgtcgtt tggtcgagca ggtttcgggc acgggctgtg tcgccagtgg
     9301 tgagggcggc gaggacggcg acctggcggc cgtccagcat ccgggtcccg atgccgcggt
     9361 gctgctcgat gtgcgcgagg gcttcctccc agcggccttc ggtggtgagg gtacgggtgc
     9421 cgtcggcaag gagtacccgc cacagccagg cgtggacttc ctgacggtcg tcagcggtcg
     9481 ccgtgaggct ggcagggatg gcgatgtcct cgaagcgggc ggctgtcccc gcaccaactg
     9541 ctgagtgcag ggcgaggagg cggcgtcggc cttcgtcgcc gcagcccgcg cgcacctgga
     9601 gtcgcgcgag gttgacggcc ggttccaggg cgcggatcgc gctcatgccc ggcaaggggc
     9661 aggcgtggag gtgcgcggcg gcatgctgtt ggcacatctc gcgggcgagg tcgggccggc
     9721 cgaggtcgga cgcgacgagg gcagcttggt tgtagacgga ggaggcgacg ccctggtccg
     9781 actcgctgac ggcggtgtcg gccaggtcgg tgatggaggc gatgcgctcg ggcagaggaa
     9841 ggcaggcggg gcggaagcgg gcgacgagcg ggaaacgctg ggcgattggc ccgtgcgggt
     9901 ccatgggttc cccccgaggg gtagagaggc ggggtacgga acggcaggtg cccgtcagca
     9961 cgtggctgac gggcaccgat cgtggggcga gctcagcccg tcagttgaag tcgacgacga
    10021 ctcggttcag cggtgtgtcg aggctgaaca ggccgggcct cggttccact cgcggggccg
    10081 tcaggtcttg cagctcgaac gtggcttcgc gcccccggta ctcgcggtcc caggtacgca
    10141 cggcgtcagc gacctgcgcc accagctcgt cgctgccggg gccgtggccg atgacgccga
    10201 attcccacag cttgcctccg tcggcggtgg tctgcttgga gacgcggcgg gcgaggtagg
    10261 tgagggcgcc cttctcgacg gctgcggtcg aggaggggta ggggtcgtcc gtgagcagcg
    10321 tccccttggc cgtcttcggg aagagcatgc ggatcaggcc ggacggcatg gagcaggaga
    10381 cgtacagctc catccactcc ggggactcca tggcgcggac cgtcattccg gtccactcct
    10441 ccacgcgcgg ctgctccagc gctccggcca gggcgtcggc gtcgatgtgc tgggcggagg
    10501 gtgcgtgcag ccgcacggct ccgtccgcgc tgagggggac gtcgcggcgg tcgtcgtcgg
    10561 cgatgccctt cctgagcggc atgaaggtgt tcatctcgga gccgacggag gtccagcggc
    10621 cgtcatgctt ctcgtaggcg atggagcggg agacgctgcc tttgagtcgc tggggtgcga
    10681 cgagtcggcc gccgggggcg agttggtcga gccacgcgtg ggggatgccg tgggcgccga
    10741 cggtggcaat gatccggtcg tagggagctc cttcggcgtg gccgacagcg ccgtcacgcg
    10801 tcagcgccgt gacgttggtg atgtcggcgg cggcgaggtg ctgccgggcg ccttccacca
    10861 gatcgtcgtc gacgtcgatg gtggtgatgt ggccgtgctc gccgacgagg tggccgagga
    10921 gtgctgcgtt gtagccggtg ccggcgccga gttccaggat gcgttctcct ggctgggctt
    10981 cgagccggtc cagcatgagg gcgacgatga ccggttggga ggcgcaggag atcgacgtgc
    11041 cgtcgttgtc gtgctttacg tcgacgacag tgttggcgta ggccgcttcc agtgccgcgt
    11101 tggggacgaa caggtgccgg ggcacggtgc gcagggcggt ctccacctcg ggggtgcggg
    11161 cgcggccgtt ggccttgatc tggtcgacga gggcgttgcg gagttgctcg gcgtcggcct
    11221 cgggggttgt ggtggtgtct gtgttcaccg cgctgacgct atcggccgtg gcgtgtgttc
    11281 cggctgctga cgtgttgtcg tgcgattcca tgactacctc tcgtgcgacg tgggacaggg
    11341 cgtgctggtc ctccggtgag agaccggcac ggttggcgtg gaaaaggacg tggtgggcga
    11401 gcacggcgcg caggccgcgg gtgagcccgt cctgtgtggc gagtccggcg agacctgttc
    11461 cggtccgttc gaaggcggac acccactcgg cgtgtccatc gagcgggccg ccgggccggg
    11521 tcaggtcggc ggtgttagcg gtcatcaagg tgcgcatcgc cggggccagg gctgcgcgtt
    11581 gctctggggc gatgggctcg ggagcccggc ggaggtcggc gtacttcgcc cagacgtcgc
    11641 cctgctcgta ccagtccagg ccggcggctc gcatcatggc gctggcgaga agaaccgcag
    11701 tctcccggcg gccgagatgg ccggggccgg ggcggtacgt aagcaggtgg cggctgtcca
    11761 ggtggaacag gctgtgtgcc gcgtctatgg cccactggcc gcccagggcg aacgtctcgg
    11821 gctcgtagat gccggacagc caggagcgca ctgtgccgtc ggcgacgagg tcgctcaaga
    11881 ggcgctgcac ggtgggggat gcctcgggcg ccctgtagcg cagtggccag ggctgcttgt
    11941 tcatgaacca ccagcccgtg atctcacccg cctcctccgc cgcgaggagc gcgggcgcga
    12001 tgcgttcggg gatggcgctc tgcgcgatct cgcggttggg aaacacgacg ttgtgctgat
    12061 gccagcggtc cgggggcatg gacgtccttt cgatcggtgg ttcaggcgat gaggaggcag
    12121 gagtcccacg cggtgtgggg cggggtaccg gtggcggggg ccagcactgc cagcgcgatg
    12181 cctgcggcgc catcgaggaa ccccggcccg gcctcgttcg ccacggcagc gtcgacgggg
    12241 tcggtgtcgg gcggacagac ggtgctcaag agcgccggga tggcgtcccg gagctgggcg
    12301 gcggtggagg ggtgggcgtc gtcggcggcg cgtgaggcca cgtgggcgag tccggcgaag
    12361 ccgtggcaca ggccgttgtc ggtcgtcgct cggagctggg cgggatcggt gagggccgcc
    12421 acgagggccg tctccgcctc gacctgacga ggcgcctcgt tcaaggcgag ggcggcgagt
    12481 tgctgagcac gggcaacgcc ggcagtgccg tagcaccagg acggtcgtcg cggcgcggag
    12541 ggcgcgaggc tgtcggcgcg cagctcggcc cgcgtgaccc agtacggcca ggcttgcccg
    12601 tgccagcggc tcagccacgc caggatggtg cgcatcgcgt cgtgctgccc gtcgacgact
    12661 gtgccgtgcc gggcggccag ggccagcagt gcgaggactc ccccgacacc gtgcgacatg
    12721 ccgtggttgg cgtgcccctc ggggaattgg tcgtcgagtc ggcccatggg tgcagtcggg
    12781 gcccaccagc ccggaagcct ctcgccgcga tcggtgatgg gcctggtcag acggacgcag
    12841 taatccagca catcacgcag ggcgccgcca gcgggctggc ggcgcagaag gtaagagccg
    12901 tagcccgtca gacctcggat cacgtcgaac tccgcgaact gcgggagctg ccccgcgtcg
    12961 aggcggcggt gcgcggccga gagacgccga cggacgtcac ggaccatctg ctcgtccagc
    13021 ttggtcaagg cacgttcata cgagcccggt tgatggtcgg cggcgcaggc gacggcgtgc
    13081 gcgagggcgg gagccccgta gaaggggtgg ctgtccgggc cgctagtgac gggctgccgg
    13141 gcggcggaaa agagccagtc atgggcgcgg ctccacggtg cgagtccagc cgcggcgcgt
    13201 tcgatgtgga gcagtgcgat acccggcatg ccgtaggcga ggtgctgccg gtcctcgagt
    13261 accagtgggc gggcgtcagg gtcggccagg gagtcagcga tcgcggccga cagcgcttcg
    13321 gatgtggtca tggctgtgtt cccatctgct tctcggcacg ggccgtccag gccagggccg
    13381 cagcccgcgc gaggtagagg cagatctcct cttcggggaa gttcaccgcc acgtgccgca
    13441 cgaagtgggt gtgcagcagg gaggtgagga cgtcgtcgag ggcgatgccg tcggtgtgcg
    13501 gtcccagcag atgcggccgg tatgtggcga gcgcagcaac gcggtcgacc cacgctgcgg
    13561 caatggctgt tccgcccggc ttgctgcgca gcgccgccca gtcgtcggtg gggtcggcga
    13621 gccgtacggc ttcggtgaac tgcggccggg gcacctggtt gggtgcggtc gccggaatgt
    13681 ggtcgatcag ccagcgcatc ccagcctcca cgccgccgag gaatccggcg gcgatggcga
    13741 ccgtgtgcgc ggcgaccagc gcacgctgag gtgggcgctg cggctggcgg agctgggcga
    13801 ggatggcgcg cgagtcggcg cggaacacgt cctcggccgc ttcccacgcc gggccggagc
    13861 cccaccggcc catctcccgg tacgaggtgg ggtagcgcag gtccgacagc agcccggcgg
    13921 cacgcagctc gtcggcccac gcgctgacgg tgcgggcggt tgccgcgaac gcgtcggggg
    13981 acgggaggcc gatgcggagg cgaacgtgcg ggtcggggtc gcggaagcgg atgaaccacc
    14041 agggcggatc gcccaaccgg cccagcagct cccgcagata ccgtgccagc agctcatctt
    14101 gacggcgtgc gtcgccgtac agggcggcca gtagcacagg cgcggcggcg ggcgtctgct
    14161 gctgctccgg agagaacgtc cgggccagcg tgggggcggg gagccgtggc catgtcgcgg
    14221 gccgggtcgc tttcagcggc acgacgacct cgtgggcgcg gccgtcgcac cacccgtacg
    14281 cgtcctgctc gggcgcctcc tggagatgag ccgtgcccgc acggtcgaga tgggcgcgca
    14341 gcagtgtccg gtggcccgcg tcgtcgaggt cgaggaagag gcggcgatcg tcttcgacga
    14401 ggaggacccg ccgcggtgcg tgccgtcgtt cccgccagtc ggtgagcgcg gcgtcccagt
    14461 tgtgcggggg tagctccgcc gcgtccagga gccaccgcgc aggtgcgagc accgtccggc
    14521 cgtaccgcag ccgtggcagg aacggcagcg cggacgccgc gccccagtcg aacgtggtga
    14581 cttgggcgca ctgggcgcgg gacagctcgg tgaggaaccg cactagcggc ggggtgtgcg
    14641 tgcgcaggtt cagcgcatgc aggcccacgg cctcgatgcg ccgcccgcgc ccggggtcgg
    14701 ccaggtacat gcgccggccg tcgcaggcca ccgccagatt gtcgggggtg agtacgtcgg
    14761 cgccgtcggg ggtgcggtgc tcctgaacgc tgatcaccgt ggggtggatg cgcggggcgc
    14821 gggtgacgtg ggtactcgcg ggcagcagcg gcgggaagga gagctgagcg ggaacggtgt
    14881 cctcgtcggc ggcgggtacg tcggccagct ctgcgatcag ggccttccgg tcgtcggggg
    14941 ccagcacgct gaggaatcgg cccgtggaga cgcctgcgcc acgggagacg ctgccgactt
    15001 ccagccggaa ccggccgcgc tggaggtcgt cgaggctgga ggcgtctacg cgtacgccga
    15061 cttcgaggtg cggcgggatg cgtggctgct cggggccgat gtccagctcg gccaacagct
    15121 cgtcggtcag ggccacttcg gtgccgccct cgagcgccgc tgcctgtgcg atccgcagca
    15181 gcgcgtcgtc acgggcggag aggcgtgccc ggcctgcgcc ggacggtgcg ccgggatagc
    15241 cgtcggggaa gccggtgccg ctgtcggcga ggacgtcgcg aagcggcacc atcgtgccga
    15301 tgccgtaccg ctcgtagaac cgctgatggt aggtccgcca tgcctcggtg ccgtacgggc
    15361 gggcgcacac ccgcgtcagc acccaggcgg cacgctcgac ttcgcgggcg accgcttccg
    15421 gcaaggcgag ctgcacgtcc aggcgcacgt ccagggccag cgggtgacgg cgcagttccg
    15481 gtgtcagtgc gcgcatccgc gtggcgacgc gatcccgccc gtcccgtacg ccgtacacgt
    15541 ccaggccggc ccggatggcg cgcagctccc gcatcgtctc cgcgaccggg gccaggccgt
    15601 cggcgtcgac gtcgtcgagt cgcgcgagca ggtaggtgag ggcgtcagtt tcggtgctcg
    15661 gcgcgtgcag gctcgtgatg aggacgcggc gggcgagcag ttgtccgatg aggttctgca
    15721 ccgtctcgcg gcccgcggtg gggaattccg cacagagctt gtcggcgagc gcaccggtcg
    15781 ggaggggcgc ccgggctgcg gcgaggactg accgcacggg ggccgttgac gccaacgaca
    15841 cctcaacggc gcgtgcttgg ccgtcgtcgg catctggctc gtacggcacg atgagccggt
    15901 ccccgcgggt ggtgacggcg gtgttcacca cgacggggag ccgttcgagg agatcggggc
    15961 acttctccag ccgggcgatg acggcgctca gccactcggc gccggcgcgt gcggtcacgg
    16021 cgtgcctgcc gccccactcg gcgcgggccc gaggcgcgaa cgtcgcggcc gtcactccgg
    16081 cgaacagccc gaaggggctg ggtcgatgct gcgcccgcag caggtagcgg gccacggaca
    16141 gcaccgtttt gtggagctgc cgcgcttcgg gtactgcggc ggagcacagc gactcaacgg
    16201 aagcggcaag tacgggactt gcgtgacgca gtccctcggc cacgtcgtcg atcgcccaga
    16261 cggctcgcag ccactgcgct tgcgcggatg tcgcagcagt cgaccggtcg tcaagctcag
    16321 gccaggtggg gaccggtagg gtcggccctg tgactgcgcg gacgagggcg gttgggccgg
    16381 atcggaacgc tggggcagcc aacgcgtacc tccgcaggtg acgagggagc gggacggggc
    16441 ggctggtgcc gccggtggaa accggcggca ccagcccagg ggttcaaccc cctttaggcg
    16501 acgttcgtgg tgcaggcgcc gcaggtgctt ccgcagccgt cgttggtgat gctgaccagg
    16561 ccggccgtgt cggcgacctc caccagtgcg acgtccagtt ggaagccgtc gggcacgccc
    16621 gcctgaacct ttggcgggtt gacctgggtt tcgtcggatg tggtgctgat gctgggactc
    16681 acgtgaactc cctgtcgtgg tcggatactg cgggtgcgcc agggcccccc ggttggctcg
    16741 aggctcctgg cgccccggcg cgagccgtga tcgcgtggtg cggtgcgagt gggctcgtgc
    16801 gccgggagtt ctatgggcgg cggtggccgt ggtggccgcg tcccggccgt gagcccgtga
    16861 ttcacacggc cgggacgcgg ggctcattgg gggtgcggcg ggtcgccgga gccggtgctg
    16921 aggtggccgc agcggttgca ggtgtagagc acgccgccgc cctgcacagg ctgaggccgc
    16981 atgcggtttc cgcagtggag catctgttcc tcgcccgggt acgggccgcg tggcccactc
    17041 tgctcgctgc gctgtgcgcg ggcagccgcg aagcgcctcc ggcgcctggc ccacatctcg
    17101 attgccgcct gcgagtgccg ctcggcccgc tcgccaagct gccgggtgga gttccacgcc
    17161 tgggcagcag cgacatcggc agcggttctg cccgccggta tgacccgcct ggcgggggct
    17221 gcgtcttcgg cgccgcgcca cacttgcagt tcgtcgccgc tgcgcagcag gtacgtcgaa
    17281 ccgttgtcga aacggagcat cttccccgtg agtccggcta cgagcatgtc gatgacctcg
    17341 acctgtgtac cgccgcgtag cgtgcggtcc ccgcgacgga tctcgctggg tccgacgcgc
    17401 agcatttcgg cgggcatgcg taataactcc tccgaacgtg tgtggggccg agggttggag
    17461 ccgtgtcccg gcggtgcgcc cgtgctctgc acggccagga cacggggctt atcgggcagg
    17521 cgcgttgtcg atgtcggcct ggtgccggcg aacgcgggct tcgagtcggc gtatgcatgg
    17581 cttgcaggcg aacatcggag cgctgccgga gtcggtttgt acgggtccga tccacagcac
    17641 gggccggtcg tcggcgtcgc agatccagca ctcgccgtcc tgccagacgc ggtgcacggg
    17701 gttccctcct gggtgggtgg ctccggccgt ccccctcgga gcggcgaggg acgaccggag
    17761 cccggaagcc gccgctgccc gcgagggcgc tgcaagcggg cccgcagcgg caggttcacg
    17821 cggggcatca cgagtcccgg ccgatgccgt aggtcaaggc gcccatgagc gccataacgg
    17881 ccagcgcgta cagcagttgg gcgaggcgct gtgtcatcag gcaccgcact tcacgtcggc
    17941 ccagacgcgc ttcccccagc gcagcgggtc gactccccaa tccgtcgaca gcgcgtcgac
    18001 gagcgccagt ccgcgcccgg attcgtcgtc caggccggcc tcgcgtcctt caggcatgtt
    18061 ttgggaacgg tcggtaaccg ctacgcgcac taggtgctcg tcgacgcggg agatcgtgac
    18121 ccgcacgcag tccagtcgag tgtgcgccac ggtgttcgtg accagctcgc tgaccacgag
    18181 cctggccgtg tcttccgcgc cttcgagatg ccatacgcgg agcgatgagg acaccaagcg
    18241 ccgcgccttg gccacggact ccgggacgcg gggcagcgtc tcgctgtacg acggaacccc
    18301 ggtcgcagat gactcagtca cgatgctcac ccggctcctc cgtgacgccg cgaacagcga
    18361 ctcgtctgct ttgggtggcg ggccgttgcg tgacggtcga tgcccaggtc agcgaatgcc
    18421 agcctcaacg ctatgaacat cactgcgtac gagggctcgc ctactccctg acactccgtc
    18481 atcgtcctca ccttcggttc gggggtgact ctcaggtgac acccagtgaa cgaggcgcac
    18541 gacagcggcg acaggtggaa tcaggtggaa ctacagcgca cgaccccggt gatttttacc
    18601 ttcaggctgt cgttgcctga tcgcggaggg ctaccttcgt cctgtgtacg ccaacgccaa
    18661 gctggaagcg cgaatcgagc aactcggctt ctcccaggcc gctttggcca gggaaatcaa
    18721 ccttgcggtc gaacgactga cgggctctta tggctcggtc actgacgcag acgtgcgccg
    18781 ctggctgcga tacgagacca ggtggccgca agaccgcatc cggctttgca tcgaagaggt
    18841 gctggacgcc tcgtccgagg acttagggtt catcccccga cgcaaggaca gtcgtgcacc
    18901 atcggaggac gggcccgtgc agcgtcgcgc attcgtgaat gcagtaggcg gagcgggctt
    18961 gggcttcgct actccgcagg caaggcagag acggctgggt gtcagtgacg ttgacaggtt
    19021 tcacgaggac tacgtgaaga tcctccagga agaccgggtt gtgggaggca caaggcgcgt
    19081 ggagaacctg gccatcgagc ttggtacgcg ggtccagtcc gccctcgcca ccggagtagc
    19141 cacgagtcgt gtacgggaca tgcttcatcg tcttgctgcc gaagcgatgt cggctgcggc
    19201 gtttgccgct ctcgacgcaa gctcgccgaa gcgggctcgt gcacacctag acaaggccat
    19261 gaccctcgcc ggcctgtcgc gtgatagcca gacgacgtac cgcgtttggg atcacctgat
    19321 gctcgcctca agcatgcgag agaaccacgc tgaagctgct gctagcgccg atgtgatgaa
    19381 gaggtcaacc gcagcacgac gtgaccctct ctttgcctct ctcgggcaca tgcgcaacgc
    19441 caacgcgctg gcccgactgg atcagcacac agatgcccta cgcgctctcg cactcgcaga
    19501 gaagaacttc agccgcagcc agtctgcgcg ctcagaatgg atcagcttct acggcgccgc
    19561 cgagttcgac gcactttcct cgtacgtctg gacggcggtc ggggagcacg gccgggcaga
    19621 gttctgtctg caccggacac tggcggccat ccccgaggac atggcccgcg acagagcgct
    19681 gttcaccgca cacctatccc tcgcgcaggt taggcagggc gaacttgaag tgggttgcgc
    19741 caccgcgagg aaggcgtcag ccctgcttca tcctggctct gggtcccgaa ggactgccaa
    19801 gaccttggcc aggggtcgtg aactgctcat cgcctccggg tcgaaggcgc ctgaagtaac
    19861 cgagtggacc gaggagtctc gccgatggat ctaaggcggt acgaccacgc cgacgctcaa
    19921 gacgtgcgtt cgatgctgct ggacatccac gacgaggtgt actcggacga ccccgacccc
    19981 ttccactctc gcgagcgttt cacgtacttc ctggacctgt ggtcctcgcg gaagaactgg
    20041 aggtgcgtgt ccgggtggga gaacggcggc ccggtcggct ttgcctacgg ctcagttctt
    20101 gcgcccggtg gctggtggca gggcagcacc cggccccttg gtctacgagg ccccgtgttc
    20161 gcactctctg aactcatggt gctacccaag tggcgcggga ctggcagagc caagaagatc
    20221 cacgacgcat tgctagcccc cgtagatgcg agggtggtgt cgcttcaggt ggagatcgca
    20281 cacgagaagg tcgtgcggct ctacgagagc tgggggtacc gaaaggtaga cgaggccaag
    20341 tcacacgacg actcgcccca gtacgcggtg atgctggccg accttccgct caaccggtgt
    20401 cggtaggcgg ccgtaccctt tgggcgtgac tcctccccct ttcgagccgc cagcgacgca
    20461 tgcccgggac gccatcaaca gcagcatccg cagcctgatg agccagcccc agcatcaccg
    20521 ccgcggcgag gagtacgccc ggcttcttgc cctgtggtcc gacgtcggcc tggcgaacac
    20581 ggtgaaggcg ccccaccagg gttccgagga cggtgaggcg tcttgccacc aaagccagca
    20641 ggtagcgact tgcatggacg aaagccagaa tacggcctat gccgacatgt cgatctgaac
    20701 gagcccggcc gcacaagggg gtagtacggc cgggctcggg ctcaagtcca gctcggtagg
    20761 cggttcggga ccgggtcgtc ggcgggggcg atccggcagc cccagcgcag caggtccaat
    20821 acgtaggacg tgaggagccg acgctgccgc cgctcgaagt ccaactgacg gtccagtctc
    20881 tcggcgatga cggtgaagtc cgagcgccgg tttccggcac ggccctggga gaaggacagc
    20941 agacccacta cgagggccac ggccgccgct gcgagcgccc ctacgtccac cgcgacacct
    21001 ccccctgccg ggggcgatcg tccatgcccg agacccacag gatgctgagc gcgaaccctg
    21061 cccaggcggc ggcggagccg gactttggtt ggttcttcgg ctcgtttgcg ggagttggcg
    21121 agacggtagg agtcggtgcc ggtttcgatg atggtgccgt tgaaggtgag gcggtcgacg
    21181 atggccgcgc agagccttgg gtcggtgaag atcttggtcc agccgccgaa ggactcattg
    21241 gaggcgatgg cgacgctgtt cttctcctcg cgttcggtca ggacttgaaa gaggagttcg
    21301 gcgccgtgct tgtcgagttc catgtagccg agttcgtcga tgcacagaag gtcgacgcgt
    21361 ccgtagtcga acgagctcaa cagcaagcag agcgggatgg cgggtgacga cgacgccagc
    21421 cgcgccttca cctccgtcta caggcatgcc gctgcaacca cgctcgacca ggcgggcttc
    21481 agcgcctacg tcctgggtca gacgggtgcc ggtctcatgc gacacccgcc agatcccggc
    21541 tggcgccgac gcccacgccc tcgcgcagat cctgggcgat cacgccgaag ccatcgaacg
    21601 tgccctcgga ggatgacgac gctccgaaag ttcccctgcc aaagccactt cgcgtccaca
    21661 ccggccaact gccggacccg gcgtctcggc catgccgcgc cccacagccc cgagctggag
    21721 aaggtcgccg cgttcgccgt tcgcaggatg gacgacacga gccgggcccc ttcttcgaga
    21781 cccggcatgc gcccgactgg gcacgctcag ccgccggcac ccacctggtt actggctgtg
    21841 aaagttccgc gctctacgct gcctgtacta cgcacgctcg tccggtcggt gctggcgggc
    21901 gcgccgctcg cctcgctgct gggcgcccta ccctcggcct tgtgtctgta taccaagtct
    21961 cgtgtcccgc acgtacgttg atcctcgacg aggagcgccg tctgttggag gagggtggcc
    22021 tccgcataga gccgacgttg tggtgcacgc tcgaagccga gcacgggggg ctgcacctca
    22081 ccctggcgca ggcactcaaa ggaggcggcg gcgtgccgcc gtcgacgctg tggcttcgat
    22141 ggcccgaaga cgccgagcac ggccctctgc gggaactgct gaccctgccc tcctgtccgg
    22201 aacgctttct cgcaggcacg gttgaggaag aggtctgtga cctgccgaag gatcacgcgg
    22261 ggcggcacgg cttcgagttc ggcccgccgc tgaacgacgg ggacatcacc ccggactggc
    22321 tgctgtaacc ccgcctcccg gacagcgccc ggcgccctcg ctgcccgttc gggatgagga
    22381 ggcatccgcg atcgagaagc cgcgcggaag ccgatcactg tgatgcgggt tccgggagat
    22441 tcgagtggct cagcggaagt cagacgcgcc cggccgcgcc ctagggtggc gtggtggagc
    22501 ggcagttcgt cgtcggggtg gatgaacgct tcggcgtctc ctcggtagat ggggccggcg
    22561 aggtcgtccg cactgacatc ggcatcgagt tgctccagcg cccgatgggt cgggtgggca
    22621 gctcgggcgc cgatcagctg cgagacaagc cgtgggcacc agcgttcctc ccagtccagc
    22681 aagacctcct cccgggcttc ttgatccaac agcatccatc gcatcacatt cgccgggggc
    22741 tccttggcgg ggaacatgcg cgcgaaggcg tcgttgaact caaggacttc ccatgcagcg
    22801 ttggtgagga aggccatcgt ctccagctgg tgtacggcct gccgccagat gtccgggacg
    22861 gacaactcgg cgggacgcag cggccatggt gggccgtgac cgactgcgca cacccacgtc
    22921 tcgcgccact gatactcatt caattgcagg atttccgcga cgcgttgaag gaattcagga
    22981 gtcggtctcg ttcctctacc gcattccagc ttgttgtacg tctggatgct gcacccaagc
    23041 gcacgggcta cttgactctg cgtcaatccc actgctttct taccgcgggg gtcacggggt
    23101 cggttcagcc cgagttcggc agggtcgatg cgttccctcg ccgcggtgag caagcgccgc
    23161 agacggcgac ggcgagcatc ggacaggctg gtcaccggcc tgcacctctc ccagacgtgg
    23221 acagcatcag ccacgaatgc cgtcctgggt tttgatggaa ggcgctattg aaccaaaaac
    23281 ccgactatag aaaaaccccc ggcgcggctg cacgatagat gatcgcgcca gtcgaccact
    23341 cgggggagca atacatgctg accgtaaggg acctcatttc gggacctgca gccgtattga
    23401 ggcccttggc gcccgaccca ggcgatttct cgttggctgt cagcgatttc gtgctggtga
    23461 atctcgatgc ccgagggcag caacacccct cggctcgggg ggcgttggtg cttctggaag
    23521 cagatccgtc cctgccccct gccacgcagc agcacaggac ggttcgcctg ctggcgcacc
    23581 tcgtgcgtga gcaggccacg ggcatcgttg ccatgaacga ggcaagccag ctggcactgc
    23641 tggcctcagg ggatcggctg ccgctcttcg tgccccgtcg gccgtgcacg ggcctggagc
    23701 tgcaaagcca actcctgcgg gcacagctac gggccgagcg ctcagcccat gcacgcaccg
    23761 aagccctcct caaactcgcc tcccgcctcg accggcaagg cgaaggaccg caagaggtcc
    23821 tgcgaatggt ccggcaggag acaggcgcaa ccgtccggat catcgatgta gatgcggacg
    23881 aggagaaccc aagcgaccaa gagattcccc ctcacctgct gaagctcgtc gccagcggtc
    23941 aggctgactc ggcgacagac gacacagagg gacatctgct gctgcacgcg ctgggcggcg
    24001 gatacccgcg gccggtactg gccgccgaga gcaccgtccc ctggacgcct gcccagcacg
    24061 ccttcgtcgc caccgcggcg ctgcacgtca gcctgctgcg gcagccgctt gcccttcgcg
    24121 cccagcagca gcgcctggcc gagacggcga gcgcgatgcg tgaagcggcc ctgctggctc
    24181 tcctgcgagg cacactcgca caggcaaggc tctccctgaa gggcctgggg ctcgacctgc
    24241 tcgaccatcc ctggatgcag ttcggagtac tgcgctgccc cgccggcgag gaccgcgtga
    24301 acctgcgcga ggagtgctcc cgcctcctca gccgcagcgc tctggtagca ccctgccccg
    24361 cggaaccgga cgatctgctg atcctgcgcg ggctcgacag cgccgaagcg gacacgggca
    24421 ccgcgcagct gctccttccc ctggtgaccg cgcgccccgg cagaatgctg ggactgagcc
    24481 agcctcagcc ctgggagcgc accgcgcatg tctacaactc cgcggtgaac gccctgtcgc
    24541 agacgacacc acagcgcccc ttcgccaccg atgccggtgc tccctgcatc tcgcagcagc
    24601 tcccggcctg ggcatccctc tgggccgccg gcgtcctcaa gtccaagctg gggtccctgg
    24661 cacaagagga ccgagagtcg cttcttgaga tctcctaccg cgcgctgaca atcggcacca
    24721 agcagaccgc ggggctgctg aacacccagg agcaggagag cgatccactg caccgcaaca
    24781 ccgtctccgc ccaactcacg cgcctctccg gcctgctcgg gctgggctcc tcgcggcggg
    24841 accgggcgct gctgcacttc ctcctcgacg tggcctcaca cgcgccgcaa tccgccgcga
    24901 tcgcaggcgg ccccaagaac cccacccttt cggatgtcct ggccaccccg gaggcccgaa
    24961 gcgccgcgca ccaggtcatc gcgcccttgg agacgcggca gaacacctac ctgctgaaga
    25021 ccctcatcgt ccgcgccacc agcgacagtg tcgatgaggc cgccgacacc ctgggcatca
    25081 cgcgccgggc gctgcagaaa cggctgacga tcatcggcac gaccatcggc cggcagatgt
    25141 ccggcccgcc atggggctgg ctccacgagg tgatcctcgc cctcgtcatc gccggccacg
    25201 tcagccagga cctgctcacc gaccccagcc tgccatccgc cccggccagc cggcacgatc
    25261 cagcagcctg agaacgcacc ttgcgaaacg gcccgatcat ctactcagtg ccgctgtgaa
    25321 ccacgggccc cctcatggcc gttgacccgc gacagtaagc aaggcgctgc tgcagcgtgc
    25381 taccgagtcc cgttgagcga ctgcctgacc atgcgacgac gcgtgcggca catgcggcgc
    25441 gttcggcggc cggtcgttgt gcacgtagga accgcggcag tgcacatggg aaccgcagac
    25501 cggctctgag tgcacgtggg aaccgagata gtgcacatgc gaactggccg ctggcccgat
    25561 tccgtgccta gcctcattga catgcccaac tccccacggt tccaaggcgc acacacggcg
    25621 gccctgctgc atcgccgctt acccacgagc acggcagcga gccggcaccg ccacacctgg
    25681 gcccggaaga ccggggccta cgcaaggcgc tgagagccgt agccgaactg gcccgaggcg
    25741 gcccctgcgt ggcgccggac gggatgcagc aagggtgccc gtcccaggag ttgggaccgc
    25801 tgcgacgagg agtcagccct acgagagcta tctctggatc gttcggcggt ggtgtgcgta
    25861 tgttgctgct cgcccactgg gcagagagca aacggcagtt cacgacgagg tagaggtgag
    25921 ggatgtgggg cggtcaccac cgcggccaat cgccagcgcg gcgggtagcc agctgaacgc
    25981 cgacggcgcc tgagagcagc aactctcaga cgccgcaacg gcaatgacac ccgcgccccg
    26041 gcaagggcgt ggagatcacc caccaacacc gccccggccc ctttccctgg gaccaaccgg
    26101 agcggcgcta cttcacagga gagtgtcgca tgacgcctgc cctgcgcaaa aggcccgaag
    26161 tcgcggcctg cgcggcagcc cctgcccctc gtgccgaggc cctggcccgg caactcgccc
    26221 agatgctgcc ccacgtcgcc cgg
//
