LOCUS       NZ_CP059991            22850 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptomyces gardneri strain ATCC 15439 chromosome, complete genome.
ACCESSION   NZ_CP059991
VERSION     NZ_CP059991.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces gardneri
  ORGANISM  Streptomyces gardneri
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9054805)
  AUTHORS   Kim,W., Hwang,S. and Lee,N.
  TITLE     Genome-scale analysis on the transcription unit architecture of
            Streptomyces venezuelae ATCC 15439
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9054805)
  AUTHORS   Kim,W., Hwang,S. and Lee,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Biological Sciences, KAIST, 291 Daehak-ro,
            Yuseong-gu, Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 6.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: CP013129
            Genome Coverage                   :: 187.8x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015710995.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 17:12:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,199
            CDSs (total)                      :: 8,101
            Genes (coding)                    :: 7,918
            CDSs (with protein)               :: 7,918
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 184
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 184
            Pseudo Genes (frameshifted)       :: 70 of 184
            Pseudo Genes (incomplete)         :: 147 of 184
            Pseudo Genes (internal stop)      :: 16 of 184
            Pseudo Genes (multiple problems)  :: 48 of 184
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:23:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7873974
            Orig. end                         :: 7896824
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059991.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22850
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /product="melanin"
                     /region_number="29"
                     /rules="cds(LANC_like and DUF4135)"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..22850
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /detection_rules="melC"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-ii"
                     /product="melanin"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22850
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12850](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12850
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    559..10951
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    559..10951
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5558:5951](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      5559..5951
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="2"
     misc_feature    complement(698..713)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.55"
                     /tool="antismash"
     gene            complement(811..1719)
                     /db_xref="GeneID:95693953"
                     /locus_tag="H4W23_RS35640"
                     /old_locus_tag="H4W23_35625"
     CDS             complement(811..1719)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693953"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308423.1"
                     /locus_tag="H4W23_RS35640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35625"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_055640002.1"
                     /transl_table=11
                     /translation="MQFQQLLYFVAVAETRHFTRAAERVHVSQPSLSQQIKALEQELGA
                     ELFSRARGNITLTDAGEALLPLARRILADTETARLEVQELAQLKRGRVRLGATPSLCTG
                     LLPDVLRAFHDLHPGIELLIEEGGSHDLVRELARGALDLALVVLPLPSPSPALTTVELL
                     REDLVAVSSASAPAPTRPVRIKDLRDQPLVMFRHGYDLRELTVAACRAEGFEPTFTVEG
                     GELDAVLGFVRAGLGLAVVPAMVAARAGRDLRVTALARPGLRRTIALAHRSDVAPPRAA
                     RELQRVLLASLRRTPARDADA"
     gene            1816..2541
                     /db_xref="GeneID:95693954"
                     /locus_tag="H4W23_RS35645"
                     /old_locus_tag="H4W23_35630"
     CDS             1816..2541
                     /codon_start=1
                     /db_xref="GeneID:95693954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003977935.1"
                     /locus_tag="H4W23_RS35645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35630"
                     /product="succinate dehydrogenase"
                     /protein_id="WP_079037284.1"
                     /transl_table=11
                     /translation="MALAPTRDRTTGRPPSPTPSRGFLSSTLGKKTVMAVSGLLMLGYL
                     VAHVAGNLKVFFGPEEFNAYGHWLRVMGAPVLHHEWALWLVRIVLLAAVGAHAVSAYQL
                     SRRDVKARPTAYVHRRKRASYATRTMRWGGIILALFIVWHILDLTTGTVHPGGFEEGKP
                     YQNVVDTFSTWYGNVIYIVAMLAVGLHVRHGFWSAAQTLGVGNARRERLLRVLADTLAL
                     VLTAGFVSVPVAVMTGVVS"
     gene            2543..4525
                     /db_xref="GeneID:95693955"
                     /locus_tag="H4W23_RS35650"
                     /old_locus_tag="H4W23_35635"
     CDS             2543..4525
                     /codon_start=1
                     /db_xref="GeneID:95693955"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386402.1"
                     /locus_tag="H4W23_RS35650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35635"
                     /product="fumarate reductase/succinate dehydrogenase
                     flavoprotein subunit"
                     /protein_id="WP_055640000.1"
                     /sec_met_domain="DAO (E-value: 9.7e-07, bitscore: 27.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFSEYATGEPITDIKAPAGPVAERWDTRRFEAKLVNPANRRKHR
                     IIVVGTGLAGGSAGATLAEQGYQVVQFCFQDSPRRAHSIAAQGGINAAKNYRNDGDSIH
                     RLFYDTVKGGDFRARESNVHRLAQISVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVS
                     RTFYARGQTGQQLLLGAYQALSRQIAAGNVEMHARTEMLDLLVVDGRARGIVARDLITG
                     EISTHYADAVVLASGGYGNVFYLSTNAMNSNATAVWRAHRRGAYFANPCFTQIHPTCIP
                     RTGDHQSKLTLMSESLRNDGRIWVPKAKGDTRPAAEIPEDERDYYLERIYPSFGNLVPR
                     DIASRAAKNVCDEGRGVGPGGQGVYLDFADAIRRMGRAAVEEKYGNLFDMYARITAENP
                     YEVPMRIYPAVHYTMGGLWVDYDLQTTVPGLFAIGEANFSDHGANRLGASALMQGLADG
                     YFVLPATINDYLARHPYAEPVTDEHPAVRDVLAETEDRLNLLLAVDGDRTPDSFHRELG
                     ELMWEFCGMARTETGLRKALARIPQIREEFWRRVKVPGTGAEFNQSLEKANRIVDYLEL
                     AELMCLDALHRAESCGGHFREESQTPDGEAARHDEEFAYVAAWEFRGPGGRPPGEHGTA
                     PGTSPVLHKEDLTFEYVHPTQRSYA"
     gene            4522..5268
                     /db_xref="GeneID:95693956"
                     /locus_tag="H4W23_RS35655"
                     /old_locus_tag="H4W23_35640"
     CDS             4522..5268
                     /codon_start=1
                     /db_xref="GeneID:95693956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330439.1"
                     /locus_tag="H4W23_RS35655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35640"
                     /product="succinate dehydrogenase/fumarate reductase
                     iron-sulfur subunit"
                     /protein_id="WP_055639999.1"
                     /transl_table=11
                     /translation="MKLTLRVWRQRNADTPGAMSTYDVDGISADMSFLEMLDTLNEALI
                     LCGEDPVAFDHDCREGICGACSLVINGDAHGPERTTTCQLHMRSFRDGDTIDIEPWRAA
                     AFPVVKDLVVDRSAFDRVIQSGGYISAPTGSAPEAHATPVPKADADSAFEHAECIGCGA
                     CVAACPNGSAMLFTSAKINHLNVLPQGSPERETRVLDMVAQMDAEGFGGCTLTGECATA
                     CPKGIPLPSITAMNREWLRARRKVKG"
     CDS             5291..5449
                     /gene="allorf_7879265_7879423"
                     /locus_tag="allorf_7879265_7879423"
                     /protein_id="allorf_7879265_7879423"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGSATRRALRRKIIHRMITFSVRSSLRGAACHPDSKINSVQICTL
                     CGKLSTS"
     CDS_motif       5291..5377
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGSATRRALRRKIIHRMITFSVRSSLRGA"
                     /locus_tag="allorf_7879265_7879423_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5378..5449
                     /prepeptide="core"
                     /locus_tag="allorf_7879265_7879423_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.80"
                     /molecular_weight="2297.6"
                     /monoisotopic_mass="2296.2"
                     /core_sequence="ACHPDSKINSVQICTLCGKLSTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGSATRRALRRKIIHRMITFSVRSSLRGA"
                     /leader_location="[5290:5377](+)"
                     /alternative_weights="2315.7"
                     /alternative_weights="2333.7"
                     /alternative_weights="2351.7"
     misc_feature    5327..5341
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.4"
                     /tool="antismash"
     misc_feature    complement(5329..5343)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.14"
                     /tool="antismash"
     misc_feature    complement(5331..5345)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(5331..5348)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.98"
                     /tool="antismash"
     CDS             complement(5400..5546)
                     /gene="allorf_7879374_7879520"
                     /locus_tag="allorf_7879374_7879520"
                     /protein_id="allorf_7879374_7879520"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVCATGGLVICPRQRPSLPGGEGGAEITGRRLATKWTTCHTMYRF
                     ERS"
     CDS_motif       complement(5484..5546)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVCATGGLVICPRQRPSLPGG"
                     /locus_tag="allorf_7879374_7879520_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(5400..5483)
                     /prepeptide="core"
                     /locus_tag="allorf_7879374_7879520_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.80"
                     /molecular_weight="3050.4"
                     /monoisotopic_mass="3048.5"
                     /core_sequence="EGGAEITGRRLATKWTTCHTMYRFERS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVCATGGLVICPRQRPSLPGG"
                     /leader_location="[5483:5546](-)"
                     /alternative_weights="3068.4"
                     /alternative_weights="3086.4"
                     /alternative_weights="3104.5"
                     /alternative_weights="3122.5"
                     /alternative_weights="3140.5"
     misc_feature    complement(5408..5423)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.33"
                     /tool="antismash"
     gene            5559..5951
                     /db_xref="GeneID:95693957"
                     /gene="melC1"
                     /locus_tag="H4W23_RS35660"
                     /old_locus_tag="H4W23_35645"
     CDS             5559..5951
                     /codon_start=1
                     /db_xref="GeneID:95693957"
                     /gene="melC1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947258.1"
                     /locus_tag="H4W23_RS35660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35645"
                     /product="apotyrosinase chaperone MelC1"
                     /protein_id="WP_055639998.1"
                     /sec_met_domain="melC (E-value: 1.9e-46, bitscore: 156.7,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHITRRRALGIAAGAAGAAAGLAVAGSAVADAPRAAAPAAGPAP
                     ASFDEVYQGRRIQGGPAHGGGHHGGHHGGGYSVTIDGEELHVMQNADGTWISVINHYEP
                     VATPKSLARAAVRELQGAPLVPLTLG"
     gene            5975..6802
                     /db_xref="GeneID:95693958"
                     /gene="melC2"
                     /locus_tag="H4W23_RS35665"
                     /old_locus_tag="H4W23_35650"
     CDS             5975..6802
                     /EC_number="1.14.18.1"
                     /GO_function="GO:0004503 - tyrosinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693958"
                     /gene="melC2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="H4W23_RS35665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35650"
                     /product="tyrosinase MelC2"
                     /protein_id="WP_055639997.1"
                     /transl_table=11
                     /translation="MTVRKNQASLTADEKRRFVDALLELKRSGRYDTFVTTHNAFIMSD
                     TDNGDRVGHRSPSFLPWHRRFLIEFEQALQSVDATVNLPYWDWTADRTSRSSLWAPDFL
                     GGTGRARDGQVLDGAFARSANRWTINVRVDGRDYLRRDLGAGGRQLPTRAEVDSVLAME
                     TYDMAPWNSSSNGFRNHLEGWRGVNLHNRVHVWVGGQMGTGVSPNDPVFWLHHAFIDKL
                     WADWQARHPKSSYLPAAGTANVVDLGDTMRPWNDVTPADMLDHTRHYTFDTAA"
     gene            complement(6856..9216)
                     /db_xref="GeneID:95693959"
                     /locus_tag="H4W23_RS35670"
                     /old_locus_tag="H4W23_35655"
     CDS             complement(6856..9216)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693959"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240682.1"
                     /locus_tag="H4W23_RS35670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35655"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_055639996.1"
                     /transl_table=11
                     /translation="MQDSPQDPYVRVRGAREHNLAGVDVDIPRDALVAFTGVSGSGKSS
                     LAFGTIYAEAQRRYFESVAPYARRLIHQVGAPAVGEISGLPPAVSLEQRRSSPNARSSV
                     GTVTTLSNSLRMLFSRAGHYPEGAERLDSDAFSPNTATGACPSCHGIGRVHETSEELLV
                     PDRDLSIREGAIAAWPGAWQGKNLRDVLDTLGYDVDRPWRELAAKDREWILFTEEQPVV
                     TVHPVREADRIQRPYQGTYMSARRYVLRTFADSKSTTLRAKAERFLTSAPCPVCGGSRL
                     RPEALAVTFAGRSIAELAALPLTVLSGLLSETPVEGAETARVLTEDLVARIATVTELGL
                     GYLSLDRATPTLSNGELQRLRLATQLRSGLFGVVYVLDEPSAGLHPADTEALLVVLDRL
                     KAAGNSVFVVEHHLDVVRHADWLVDVGPRAGVHGGHVLYSGPPEGLAAVEASATRRFLF
                     DREPVPARTVRTPADWLRTGPVTRHNLRAVDAAFPLGVLTAVTGVSGSGKSTLVGALTE
                     ELPGVGRLVTVNQRPIGRTPRSNLATYTGLFDVVRKLFTETAEAKERGYKAGRFSFNVP
                     GGRCETCQGEGFVSVELLFLPSTYAPCPDCHGARYNPETLRVRWRGLTIAEVLDLTVES
                     AAEFFDDVPAAARSLRTLLDVGLGYLRLGQPATELSGGEAQRIKLASELQRPRRSATLY
                     VLDEPTTGLHPADVEVLMRQLHGLVEAGHSVIVVEHDMDVVATADWVLDLGPGGGDEGG
                     RIVAAGPPDRVARAAESRTAPYLLRALGPAGRS"
     gene            9678..9881
                     /db_xref="GeneID:95693960"
                     /locus_tag="H4W23_RS35675"
                     /old_locus_tag="H4W23_35660"
     CDS             9678..9881
                     /codon_start=1
                     /db_xref="GeneID:95693960"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240677.1"
                     /locus_tag="H4W23_RS35675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35660"
                     /product="DUF6229 family protein"
                     /protein_id="WP_055639995.1"
                     /transl_table=11
                     /translation="MPVISATRTDAIVTAWLQGAETAFGADNPAGPLYVGGAAGEAALT
                     DATEALLTGCSSCTGSWHSYCC"
     CDS_motif       9678..9755
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPVISATRTDAIVTAWLQGAETAFGA"
                     /locus_tag="H4W23_RS35675_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9756..9881
                     /prepeptide="core"
                     /locus_tag="H4W23_RS35675_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.10"
                     /molecular_weight="3877.2"
                     /monoisotopic_mass="3874.7"
                     /core_sequence="DNPAGPLYVGGAAGEAALTDATEALLTGCSSCTGSWHSYCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPVISATRTDAIVTAWLQGAETAFGA"
                     /leader_location="[9677:9755](+)"
                     /alternative_weights="3895.2"
                     /alternative_weights="3913.2"
                     /alternative_weights="3931.3"
                     /alternative_weights="3949.3"
     gene            10001..12850
                     /db_xref="GeneID:95693961"
                     /locus_tag="H4W23_RS35680"
                     /old_locus_tag="H4W23_35665"
     CDS             10001..12850
                     /codon_start=1
                     /db_xref="GeneID:95693961"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240676.1"
                     /locus_tag="H4W23_RS35680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35665"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_055639994.1"
                     /sec_met_domain="DUF4135 (E-value: 4.8e-67, bitscore:
                     225.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.2e-36, bitscore:
                     123.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEPVAAARSADGAPPEGWFAAPVNTFVGPLFAELDDRIPQTAGL
                     TADERAVLREATREALGRTLQLRLNRVLLLELRAAALADELPGADSAARWDSFLRHASA
                     PAFTETLHRRYPALLDRVFASGRLLIEGALELGTRLATDREAVAGLLGGDPGPLRGLEL
                     ARGDTHHGGRAVARVLFETGSVMYKPRPTEVDAALRSFVAAVPGAEDLGVPRVAVEDGY
                     GWAEHLGHHYCRDEAELARFYRALGGWLAVMRLLGGTDLHAENLVAHGPMPAVVDAEAL
                     FTPDVEVPPSGRGDAVDRAARTIRNTVLRTGILPLRTDGYALAGVDLSAAGGLPGQQPQ
                     IRVPVIADGGLDTARMEIGVVDLPPAGNHPSPEPVLIRHWDQVLTGFDRLTGALAKLDA
                     GGELGTLMKVFDGCQVRRIRRPTQTYTDIGRMLWHPASLHDPEAALARARDILHRNALA
                     APGAPREPAVIDGEIADLLIGDVPVFGERVDGQRLTAFLTGWRQADLTRERDTIRSALV
                     GAYLNERQLPDRVRTPARSPSAEDLDRRRRTLAAAAVDTICAAAVRGTDATATWISPVL
                     TDYGWAVRPLGADLYTGQGGVALALAEYLREQRAGRADPVADVEPVLAGTLEVLASTED
                     TMPTRQLGGFTGLASQVWTWAALHRVLGTPGLLDRARARAALLTPEIVAEDRALDVLGG
                     AAGVIVPLLDLAELTGQERWVDVAAEAGRRLERTAVVDDRGARWSTVMFPEGIGGFAHG
                     ATGAGWALTRLALSAAGSTADRRRWHELGSLAHDFEESLYSPGVRAWADARVGGEVDHP
                     TAWCHGSTGIGLAAIDLHGRTGDPRHMDTALRSAPAGLREGFGWSHTLCHGDLGLWELL
                     HRLRGLTGYEGPSAAEADAELLTGIEQRGPVGGLAKEAFAPGLLPGLAGVVHQLLRMHP
                     DARLSSPLLLALPAPTLGP"
     gene            12847..13335
                     /db_xref="GeneID:95693962"
                     /locus_tag="H4W23_RS35685"
                     /old_locus_tag="H4W23_35670"
     CDS             12847..13335
                     /codon_start=1
                     /db_xref="GeneID:95693962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240672.1"
                     /locus_tag="H4W23_RS35685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35670"
                     /product="hypothetical protein"
                     /protein_id="WP_055639993.1"
                     /transl_table=11
                     /translation="MTRDNRPLAVFDLDNTLSATAHRQHFLEGRPKNWDGFFAAASDDP
                     PLEEGIALCRKAAEECEVVYLTGRPERCRRATVAWLAAQGLPEGRIHMRSNRDFRPARV
                     TKVEVLRRLAADREVRMLVDDDVLVCDAAEAAGFHVVRAGWAAPSEALRDAQEKEGRT"
     gene            complement(13472..13690)
                     /db_xref="GeneID:95693963"
                     /locus_tag="H4W23_RS35690"
                     /old_locus_tag="H4W23_35675"
     CDS             complement(13472..13690)
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848217.1"
                     /locus_tag="H4W23_RS35690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35675"
                     /product="dodecin"
                     /protein_id="WP_055639992.1"
                     /transl_table=11
                     /translation="MSNHTYRVTEIVGTSTEGVDEAIRNGINRASQTLRGLDWFEVTQV
                     RGHIVDGAIEHYQVGLKVGFRLEDEAA"
     misc_feature    complement(13783..13797)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    13833..13848
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.38"
                     /tool="antismash"
     misc_feature    13851..13866
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.39"
                     /tool="antismash"
     gene            13970..15217
                     /db_xref="GeneID:95693964"
                     /locus_tag="H4W23_RS35695"
                     /old_locus_tag="H4W23_35680"
     CDS             13970..15217
                     /codon_start=1
                     /db_xref="GeneID:95693964"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038045.1"
                     /locus_tag="H4W23_RS35695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35680"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_055645847.1"
                     /transl_table=11
                     /translation="MKNRHLACPLAAATALALAGCGMLPGGGQTKTVNIWLMRDSASED
                     FLTRFTEAYEEEHNGVDLNITIQDWTGIGKKVTEAIEGSGGPDVIEVGNTQVAQYADTE
                     KLYDLTLESVRDLGSEDWLPGLAQPGSIGGSQYGIPWYAANRIVIYNKDLFRDAGIDKP
                     PATQAEWLADTEKLNRGGTQGIYLAGQDWYTLSGFIWDEGGELAVDKGGEWTGALGSPA
                     ALRGMDFYKKLQSLGDGPKNADEQNPPQADVFAKGDVAQIIATTSAVAPILKANPDLKD
                     KLGYFAIPGKKADQPCVVFTGGSDLIIPENAPQRGAALDVVKAFAGEKWQTELARAMGY
                     VPNKKGLASVVSGQEATAVMAAAAARGRATPNSPQWANVEGDNPIKPYMTAVLQGEDPK
                     EAAEKASAEISDTLAE"
     gene            15356..16198
                     /db_xref="GeneID:95693965"
                     /locus_tag="H4W23_RS35700"
                     /old_locus_tag="H4W23_35685"
     CDS             15356..16198
                     /codon_start=1
                     /db_xref="GeneID:95693965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038046.1"
                     /locus_tag="H4W23_RS35700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35685"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_055639991.1"
                     /transl_table=11
                     /translation="MTAPSPTLAVPAGAVSVGAVSVPAQPQPQPQARAEQAAPRYVVGL
                     ARDQEDVRAAQRLRHQVFAGELGARLDGPEPGLDSDAFDAYCDHLLVRDEATGEVVGTY
                     RILPPERAAVAGRLYSESEFDLTRLAPVRHDLVEVGRSCVHPLHRNGAVISLIWAGLAR
                     YMTRTGHNWLAGCCSIPLADGGTLAASTWDTVKAKHLAPEEYWVTPHRLWNADGIARPE
                     GRTELPPLLRGYLRLGAWVCGAPAHDPDFGVADLYVLLSLRRTNPRYLNHFLSLAPAP"
     gene            16195..17094
                     /db_xref="GeneID:95693966"
                     /locus_tag="H4W23_RS35705"
                     /old_locus_tag="H4W23_35690"
     CDS             16195..17094
                     /codon_start=1
                     /db_xref="GeneID:95693966"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038047.1"
                     /locus_tag="H4W23_RS35705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35690"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_055639990.1"
                     /transl_table=11
                     /translation="MTGSTAPSPWLPTAPCTPGRCAAHPDPAADRTVLAAGAALASARL
                     AAGIGAVLLGVLCVPAARLLPTPVRLALVRYWVRAVVRAFGVRVRFAGLPAPADRPLLV
                     VANHVSWLDIPLLAAVLPGRMVAKTEVRQWPVLGALAVLGGTLFIDRDRLRALPGTVRA
                     MAAVLAGGGRVIVFPEGSTWCGRAGGRFRPAAFQAALDGGADVQPVRIDYRPTDAAAYV
                     GDDPLGASLWRLAATRGVTADVTTLEPIPGARYPDRRSLAAAAQRAVASESANRPSSSV
                     HQRDRSSPASASSSRTPA"
     gene            complement(16989..17954)
                     /db_xref="GeneID:95693967"
                     /gene="egtD"
                     /locus_tag="H4W23_RS35710"
                     /old_locus_tag="H4W23_35695"
     CDS             complement(16989..17954)
                     /EC_number="2.1.1.44"
                     /GO_function="GO:0052706 - L-histidine
                     N(alpha)-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693967"
                     /gene="egtD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038048.1"
                     /locus_tag="H4W23_RS35710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35695"
                     /product="L-histidine N(alpha)-methyltransferase"
                     /protein_id="WP_055639989.1"
                     /transl_table=11
                     /translation="MSPFQLTRTLAPDAAGADLRTDVLHGLSRSPKTLPPKWFYDARGS
                     ELFEEITRLPEYYPTRAEREILIARAPEIAAATGARTLVELGSGSSEKTRFLIDALLPG
                     LDGYVPVDVSESALTGAAESLLADRPELRVHALVADFTRGLALPGMPGPRLVAFLGGTI
                     GNLLPAERRTFLRSVRAMLTPGDALLLGTDLVKDEETLVAAYDDAAGVTAAFNKNVLSV
                     IDRELGADADPGDFDHVAVWDRDREWIEMRLRARHALTVKIPELDLVVPFAAGEEVRTE
                     VSAKFRQAGVRDELAEAGLDLSRWWTDEEGRFALSLATAR"
     gene            complement(17951..18703)
                     /db_xref="GeneID:95693968"
                     /gene="egtC"
                     /locus_tag="H4W23_RS35715"
                     /old_locus_tag="H4W23_35700"
     CDS             complement(17951..18703)
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693968"
                     /gene="egtC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038049.1"
                     /locus_tag="H4W23_RS35715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35700"
                     /product="ergothioneine biosynthesis protein EgtC"
                     /protein_id="WP_055639988.1"
                     /transl_table=11
                     /translation="MCRHLAYVGGPVALGELLVRPEHALLRQSWEPRHQTSGVVNADGF
                     GVGWYAEGDPVPARYRRAAPIWGDLSFADLARVVRTGALLAAVRGATLAGADGEAATAP
                     FTAGPWLFSHNGAVTGWAESLAALAGALPAEALLQLEARTDSALLWALVLHRLRAGDAP
                     GTALADTVREAAAAAPGSSLNVLLTDGTTVTATRWGNSLWYLTGPDRVVVASEPYDDDP
                     RWREVPEHTLVTADRGDVTLTPLKEPSA"
     gene            complement(18703..20079)
                     /db_xref="GeneID:95693969"
                     /gene="egtB"
                     /locus_tag="H4W23_RS35720"
                     /old_locus_tag="H4W23_35705"
     CDS             complement(18703..20079)
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693969"
                     /gene="egtB"
                     /gene_functions="other (smcogs) SMCOG1226: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568094.1"
                     /locus_tag="H4W23_RS35720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35705"
                     /product="ergothioneine biosynthesis protein EgtB"
                     /protein_id="WP_230883194.1"
                     /transl_table=11
                     /translation="MTGTQRATGTEQAPAIDPVDPIDPVDPEALRARALAALTVARERT
                     ALLTSCVDDEELTAQHSPLMSPLVWDLAHIGNQEEQWLWRAVAGRDALRPEIDSLYDAF
                     EHPRASRPSLPLLPPGEARAYAADVRLRILDVLESAPLEGRPLLDDGFAFGMIAQHEQQ
                     HDETMLITHQLRRGPAALTAPPPPTPRSGPLPPEVLVPGGPFTMGTSEEPWALDNERPA
                     HARIVPAFFVDTTPVTNGAYLAFMADGGYTDRRWWRPEGWAQIREHGIGAPLFWRRDGG
                     QWLRRRFGVTEPVPLDEPVLHVSWYEADAYARWAGRRLPTEAEWEKAARHDPVSGRSRR
                     YPWGDADPGPEHANLGQRHLRPAAAGSYPEGASPLGVRQLIGDVWEWTASDFLPYPGFT
                     AFPYKEYSEVFFGPEHKVLRGGSFAVDPVACRGTFRNWDLPVRRQIFSGFRTARTAEFG
                     "
     gene            complement(20076..21335)
                     /db_xref="GeneID:95693970"
                     /gene="egtA"
                     /locus_tag="H4W23_RS35725"
                     /old_locus_tag="H4W23_35710"
     CDS             complement(20076..21335)
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693970"
                     /gene="egtA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038051.1"
                     /locus_tag="H4W23_RS35725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35710"
                     /product="ergothioneine biosynthesis glutamate--cysteine
                     ligase EgtA"
                     /protein_id="WP_055639987.1"
                     /transl_table=11
                     /translation="MAASGTPRGGPPLTESEAEELLRGICFKTGPPRTVGAELEWLVHD
                     LRDPRLPVRPPRLAAALDTVRSLPLVSSLTFEPGGQLELSSRPAGSLMECLDSLAADLR
                     AVREALGPLGLTLNGYGVDPWHAPRGRVLHEPRYDAMEIALDRTGPAGRAMMCDSASVQ
                     VCLDAGLDEPGPLGYHRRWRLAHLLGAVLVAVFANSPVHGGRRTGWRSTRQALWTNLDP
                     RRALAPPPDGKPRDEWTAHVLDTPVLCVRADEGPWAVPEGLTFREWLRTGLPRPAGLDD
                     LNYHVTTLFPPVRPRGHLELRMIDAQPGPDGWMVPVAVTTAVFEDPEAAEAVHRAVEPL
                     AERAGPGPAPRNPLWLAAARDGLTDPGLHTAARAVFSAALAALPRIGASEEVRRSVAAF
                     QERYVIPGGCPADELQVVTS"
     CDS             21384..21551
                     /gene="allorf_7895358_7895525"
                     /locus_tag="allorf_7895358_7895525"
                     /protein_id="allorf_7895358_7895525"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPLLPPKATADPRARAPHSDRTRPLCPPWPETSPGGGNLGKSVVP
                     ARGKRSCWRS"
     CDS_motif       21384..21491
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MPLLPPKATADPRARAPHSDRTRPLCPPWPETSPGG"
                     /locus_tag="allorf_7895358_7895525_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       21492..21551
                     /prepeptide="core"
                     /locus_tag="allorf_7895358_7895525_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.90"
                     /molecular_weight="2004.3"
                     /monoisotopic_mass="2003.1"
                     /core_sequence="GNLGKSVVPARGKRSCWRS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPLLPPKATADPRARAPHSDRTRPLCPPWPETSPGG"
                     /leader_location="[21383:21491](+)"
                     /alternative_weights="2022.3"
                     /alternative_weights="2040.4"
     gene            21548..22378
                     /db_xref="GeneID:95693971"
                     /locus_tag="H4W23_RS35730"
                     /old_locus_tag="H4W23_35715"
     CDS             21548..22378
                     /codon_start=1
                     /db_xref="GeneID:95693971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038052.1"
                     /locus_tag="H4W23_RS35730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35715"
                     /product="TIGR02452 family protein"
                     /protein_id="WP_055645845.1"
                     /transl_table=11
                     /translation="MSARLREIARKTEEIVAAGGYRAPDGRTVSLAEDLTAALAGTRLH
                     GPEPVPVTPDTDRTATLDVTGESSLAAARRMVSADPARPVAVLNFASARNPGGGYLNGA
                     QAQEEALCRASALHATLLRAPDYYAHHRADPDVFYTDRVIHSPRVPVFRDERGALLDEP
                     FTVGFLTSPAPNAGVVRRRTPERAAQLPAALATRAERVLETAAAAGYRRLVLGAWGCGV
                     FQNDPTVVAGAFGALLRGDGRFAGHFEEIVFAVLDCSSGAPTLAAFARVLASPV"
     gene            22442..22627
                     /db_xref="GeneID:95693972"
                     /locus_tag="H4W23_RS35735"
                     /old_locus_tag="H4W23_35720"
     CDS             22442..22627
                     /codon_start=1
                     /db_xref="GeneID:95693972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240663.1"
                     /locus_tag="H4W23_RS35735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_35720"
                     /product="hypothetical protein"
                     /protein_id="WP_055639986.1"
                     /transl_table=11
                     /translation="MGGTIVGKKQTRTNRGARTGGHEHRTEAAAKEKTAATPTREPQMP
                     LVEHASHRKERKFGHN"
ORIGIN
        1 ggtcaccgtg tcgaacagcg gggtcgtgcc cgcccggagc cgggcgaggt tgacgacggc
       61 gcggttctcc cggatcggga tctcctcggg ctgggggccg tccgcgccgt gctcggccag
      121 cacggccaga tcgcgcaggt gctcctcgcc gagcggggtc gtgctcccgg ccagggccag
      181 atagagcgcg gtgacctcgg tgtccccgtc atcgccgagg tgcagcacgg tcagccggtc
      241 acccgccgcc gcgatcagct cgtcgtgcgc ggcgagcatc tcctcgtacg tgtgccggta
      301 ccggccgtac gaggggaggg tcagcagatc gaggacgccc tcgcgcagct ggtcgagcgt
      361 ccgggcgcgg gcgtcgccgt cgtcgagcgt ctcggcgacg caggcgatcc agaagtcgag
      421 cgtgtccggc acgttggccg ggaagtcgat gaagtagacg ttgtgccgga cgtggtcgcc
      481 gacgagctcg cggaccgtgg cgagcgtgcg gacggcggtc tcgacgacgg tcggctcggc
      541 gaaccccgaa aggcgctcga tcagctcggc cgagagcttg aaccccgcgg tcatcagggc
      601 cgcgtcgaac cggcgcgcgg cggcggcccc gtccccggca gggccggcgg gagacgggag
      661 acggtgggta tggcggacga ccaggtgttc gagagcgtgg accatacggg catgctcgca
      721 gccgccgacc gccgaccgca cggggttttg tcccaccgcc tcggtcggtc accgccgccc
      781 ggtcgggggt gctccggccg ctgtttccgg tcaggcgtcc gcgtcgcgcg ccggggtcct
      841 ccggagcgag gcgagcagga cccgctggag ctcccgcgcc gcccggggcg gcgccacgtc
      901 gctgcggtgg gcgagggcga tcgtgcggcg caggcccggc cgggcgagcg ccgtcacccg
      961 caggtcgcgg cccgcccgcg ccgcgaccat cgcggggacg accgcgagcc cgagccccgc
     1021 ccggacgaaa ccgagcaccg cgtccagctc cccgccctcg accgtgaagg tgggctcgaa
     1081 gccctccgcc cggcaggccg cgacggtcag ttcccgcagg tcgtagccgt gccggaacat
     1141 cacgagaggc tggtcccgca ggtccttgat ccgcaccggc cgggtcggcg cgggcgccga
     1201 ggccgaggag accgcgacca ggtcctcccg gagcagctcg accgtcgtga gcgcaggtga
     1261 cggggacggc agcggcagga cgacgagcgc caggtcgagc gccccgcgcg ccagctcccg
     1321 tacgagatcg tgcgagccgc cctcctcgat gaggagctcg atccccgggt gcaggtcgtg
     1381 gaaggcgcgc agcacgtcgg gaaggagccc cgtgcacagg ctcggggtcg cgccgagccg
     1441 cacccggccc cgcttgagct gcgccagctc ctgcacctcg agccgggccg tctcggtgtc
     1501 ggcgaggatg cggcgcgcga gcggcagcag cgcctcgccc gcgtcggtga gtgtgatgtt
     1561 ccccctggcc cggctgaaca gctcggcgcc caactcctgt tccagggcct tgatctgctg
     1621 ggagagcgag ggctgcgaga cgtggacgcg ctcggccgcc cgcgtgaagt gccgggtctc
     1681 ggccacggcg acgaagtaga ggagctgctg gaactgcatg accccagcgt aggcgacatg
     1741 gataggtgat gcctatcgag atcagccgca ccatgtcttg gacctctggg gtccttcggc
     1801 cctagcgtcg tgagcatggc tctggcaccc acgagggacc ggacgacggg ccgcccgccg
     1861 tcccccacac cgtcacgcgg attcctgtca tcgaccctcg gcaagaagac ggtcatggcc
     1921 gtcagcgggc tgctcatgct cggctatctc gtcgcccatg tcgccgggaa cctgaaggtc
     1981 ttcttcggcc ccgaggagtt caatgcctac ggccactggc tgcgggtgat gggcgccccc
     2041 gtcctgcacc acgagtgggc cctctggctc gtccggatcg tgctcctcgc cgccgtcggc
     2101 gcccacgccg tctccgccta ccagctcagc cggcgcgacg tgaaggcccg ccccaccgcg
     2161 tacgtccacc gccgcaagcg cgcttcgtac gccacccgca ccatgcgctg gggcggcatc
     2221 atcctcgccc tcttcatcgt ctggcacatc ctcgacctca ccaccggcac cgtgcacccc
     2281 ggcggcttcg aggagggcaa gccctaccag aacgtcgtcg acaccttctc cacctggtac
     2341 ggcaacgtca tctacatcgt cgccatgctc gccgtcggcc tccatgtccg ccacggcttc
     2401 tggagcgccg cccagaccct gggcgtcggc aacgcccgcc gcgagcgact cctcagggtc
     2461 ctcgccgaca ccctcgcgct cgtcctgacc gcgggcttcg tctccgtccc cgtcgccgtc
     2521 atgaccggag tggtgagctg acatgacctt ttccgagtac gccaccggtg agccgatcac
     2581 cgacatcaag gcccccgccg ggcccgtcgc cgagcgctgg gacacccgcc gcttcgaggc
     2641 caagctggtc aaccccgcca accgtcgcaa gcaccggatc atcgtcgtcg gcaccggcct
     2701 cgccggcggc tccgccggtg ccaccctcgc cgaacagggc taccaggtcg tccagttctg
     2761 tttccaggac tccccgcgcc gcgcccactc catcgccgcg cagggcggca tcaacgccgc
     2821 caagaactac cgcaacgacg gcgactccat ccaccggctc ttctacgaca ccgtcaaggg
     2881 cggagacttc cgggctcgcg agtccaacgt ccaccgcctc gcccagatct ccgtcgagat
     2941 catcgaccag tgcgtcgccc agggcgtgcc cttcgcccgc gagtacggcg gactcctcga
     3001 cacccgctcc ttcggcggcg tccaggtctc ccgcaccttc tacgcccgcg gccagaccgg
     3061 tcagcagctc ctcctcggcg cctaccaggc actgtcccgg cagatcgccg ccggaaacgt
     3121 cgagatgcac gcccgtacgg agatgctcga cctgctcgtc gtcgacgggc gggcccgcgg
     3181 catcgtcgcc cgcgacctga tcacgggcga gatctcgacc cactacgccg acgccgtcgt
     3241 cctcgccagc ggcggctacg gcaacgtctt ctacctgtcg acgaacgcga tgaactccaa
     3301 cgccaccgcc gtctggcggg cccaccggcg cggcgcgtac ttcgccaacc cctgcttcac
     3361 ccagatccac cccacctgca tcccgcgcac cggcgaccac cagtccaagc tgaccctgat
     3421 gagcgagtcc ctgcgcaacg acggccgcat ctgggtcccc aaggccaagg gcgacacccg
     3481 gcccgccgcc gagatccccg aggacgagcg cgactactac ctggagcgca tctacccctc
     3541 cttcggcaac ctcgtccccc gtgacatcgc ctcccgcgcc gcgaagaacg tctgcgacga
     3601 gggccgcggc gtcggccccg gcggccaggg cgtctacctc gacttcgccg acgccatccg
     3661 ccgcatgggc cgggcggccg tcgaggagaa gtacggcaac ctcttcgaca tgtacgcgcg
     3721 gatcaccgcg gagaacccgt acgaggtccc catgcggatc taccccgccg tccactacac
     3781 gatgggcgga ctctgggtcg actacgacct gcagacgacc gtccccggcc tcttcgcgat
     3841 cggcgaggcc aacttctccg accacggggc caaccggctc ggcgcctccg ccctgatgca
     3901 ggggctcgcc gacggctact tcgtcctccc cgccaccatc aacgactacc tcgcccgcca
     3961 tccctacgcc gagccggtca ccgacgagca cccggcggtg cgcgacgtcc tcgccgagac
     4021 cgaggaccgg ctcaacctcc tcctcgccgt cgacggcgac cgcacccccg actccttcca
     4081 ccgcgaactc ggcgaactca tgtgggagtt ctgcggtatg gcccgcacgg agacgggcct
     4141 gcgcaaggcc ctcgcccgca tcccgcagat cagggaggag ttctggcgcc gggtcaaggt
     4201 cccgggcaca ggagcggagt tcaaccagtc cctggagaag gccaaccgca tcgtcgacta
     4261 cctggagctg gccgagctga tgtgcctcga cgcgctccac cgcgccgagt cctgcggcgg
     4321 ccacttccgc gaggagtccc agacgccgga cggcgaagcg gcccgccatg acgaggagtt
     4381 cgcgtacgtg gcggcctggg aattccgggg gcccgggggt cgccccccgg gagagcacgg
     4441 cacggcgccg ggcacctccc ccgtcctcca caaggaggac ctcaccttcg agtacgtcca
     4501 ccccacccag cggagctacg catgaagctc accctgcgcg tctggcgcca gcgcaacgcc
     4561 gacacccccg gcgccatgtc cacctacgac gtcgacggca tctccgccga catgtcgttc
     4621 ctggaaatgc tcgacaccct caacgaagcc ctcatcctgt gcggcgagga ccccgtcgcc
     4681 ttcgaccacg actgccgcga gggcatctgc ggcgcgtgca gcctcgtcat caacggcgac
     4741 gcgcacggcc ccgagcgcac caccacctgc cagctccaca tgcgctcctt ccgcgacggc
     4801 gacacgatcg acatcgagcc ctggcgcgcg gcggccttcc ccgtcgtcaa ggacctcgtg
     4861 gtcgaccgct cggccttcga ccgcgtcatc cagtccggcg gctacatcag cgcccccacg
     4921 ggctcggcgc ccgaggccca cgcgacgccc gtgccgaagg ccgacgccga ctcggccttc
     4981 gagcacgcgg agtgcatcgg ctgcggggcc tgcgtggcgg cctgccccaa cggctcggcg
     5041 atgctcttca cctcggccaa gatcaaccac ctcaacgtcc tcccgcaggg ctccccggaa
     5101 cgcgagacca gggtcctcga catggtggcc cagatggacg cggagggctt cggcggctgc
     5161 acgctgacgg gggagtgcgc gacggcctgt ccgaagggca tcccgttgcc ctcgatcacg
     5221 gcgatgaaca gggagtggct gcgggcgcgg aggaaggtga aggggtagga catccggcca
     5281 gtcttgcggc gtgggctccg ccacacggcg ggccctgcgg cgaaagatca ttcacagaat
     5341 gatcactttc tccgtaagat cttcgctcag gggtgccgct tgccacccgg acagcaagat
     5401 caactccgtt caaatctgta cattgtgtgg caagttgtcc acttcgtagc caaccggcgt
     5461 ccggtgattt ccgccccgcc ctcacccccg ggtagtgatg ggcgctgccg ggggcatatg
     5521 accaaacccc cggtcgcaca gaccaactag ggggtttcat gtcccacatc acccgccgcc
     5581 gggctctcgg catcgcggca ggcgccgccg gcgccgccgc gggcctcgcc gtggccggct
     5641 ccgccgtcgc cgacgctccc cgagccgccg ctcccgcggc cggcccggcc ccggcgtcct
     5701 tcgacgaggt ctaccagggc cgccgcatcc agggcgggcc cgcgcacggc ggaggtcacc
     5761 acggggggca ccacggaggc ggctactccg tgacgatcga cggcgaggag ctgcacgtca
     5821 tgcagaacgc cgacggtacc tggatcagcg tcatcaacca ctacgagccc gtcgccacgc
     5881 ccaagtcgct ggcccgcgcg gccgtccgcg aactccaggg cgccccgctc gtacccctca
     5941 ccctcggctg atcgatccag gaacggcacc cgtcatgacc gtacgcaaga accaggcctc
     6001 cctcaccgcc gacgagaagc ggcgcttcgt cgacgccctc ctggagctca agcgctccgg
     6061 gcggtacgac accttcgtca ccacacacaa cgccttcatc atgagcgaca ccgacaacgg
     6121 agaccgcgtc ggccaccgct cgccgtcgtt cctgccctgg caccggcgct tcctcataga
     6181 gttcgagcag gccctgcagt ccgtcgacgc gaccgtcaac ctcccctact gggactggac
     6241 ggccgaccgc acctcccgct cctcgctgtg ggcgcccgac ttcctcggcg gcaccgggcg
     6301 cgcccgcgac ggccaggtgc tcgacggcgc gttcgcccgc agcgccaacc gctggacgat
     6361 caacgtccgc gtcgacggtc gcgactacct ccggcgcgac ctcggcgcgg gcggccgtca
     6421 gctccccacc cgcgccgaag tggactccgt cctcgccatg gagacctacg acatggcgcc
     6481 gtggaacagc tcgtcgaacg gcttccgcaa ccacctcgaa gggtggcgcg gcgtgaacct
     6541 ccacaaccgc gtccacgtct gggtcggcgg ccagatgggc accggggtct ccccgaacga
     6601 ccccgtgttc tggctgcacc acgccttcat cgacaagctg tgggccgact ggcaggcccg
     6661 ccaccccaag tcctcgtacc tgccggccgc gggcaccgcg aacgtcgtcg acctcggcga
     6721 caccatgcgt ccgtggaacg acgtgacccc ggcggacatg ctggaccaca cccgccacta
     6781 caccttcgac acggcagcct gaccccgccc gaccgggtcc tcggctccgt cggccccgat
     6841 cccgccggac gggcctcagc tccgtccggc gggccccagg gcccggagca gatacggcgc
     6901 ggtgcggctc tccgccgccc gcgccacccg gtccggaggg cccgcggcca cgatccggcc
     6961 gccctcgtcg ccaccgcccg gccccaggtc gaggacccag tcggcggtgg cgaccacgtc
     7021 catgtcgtgc tcgacgacga tcacggagtg gcccgcctcc acgaggccgt ggagctggcg
     7081 catgaggacc tcgacgtccg ccgggtgcag ccccgtcgtc ggctcgtcga gcacgtacag
     7141 cgtcgcggag cggcgcgggc gctggagctc cgaggcgagc ttgatgcgct gcgcctcgcc
     7201 gccggacagc tccgtcgccg gctgcccgag ccgcagatag ccgaggccca cgtccaggag
     7261 cgtccgcagg ctccgggcgg cggccgggac gtcgtcgaag aactccgcgg ccgactcgac
     7321 ggtgaggtcc aggacctcgg cgatggtgag cccgcgccac cgcacccgga gcgtctccgg
     7381 gttgtaccgg gcgccgtggc agtcgggaca gggcgcgtag gtgctcggca ggaagaggag
     7441 ctccaccgac acgaagccct ccccctggca ggtctcgcag cgtccgccgg ggacgttgaa
     7501 ggagaagcgg cccgccttgt atccgcgctc cttcgcctcc gccgtctcgg tgaagagctt
     7561 ccgcacgacg tcgaacagcc ctgtgtacgt ggcgaggttg gagcgcggag tccgcccgat
     7621 cggtcgctgg ttcaccgtca ccaggcgccc cactcccggg agttcctcgg tcagcgcgcc
     7681 gacgagcgtc gacttgcccg aacccgacac gcccgtgacg gcggtgagga cgccgagcgg
     7741 gaaggccgcg tcgaccgccc gcagattgtg ccgggtcacc ggccccgtac gcagccagtc
     7801 cgccggggtc cgcaccgtgc gcgcgggaac cggttcccgg tcgaagagga aacgccgggt
     7861 cgcggacgcc tcgacggccg caagcccctc cggcggaccg ctgtacagga cgtgcccgcc
     7921 gtgcaccccg gcccgcggcc cgacgtcgac gagccagtcg gcgtggcgga cgacatcgag
     7981 gtggtgctcg acgacgaaga ccgagttccc ggcggccttc agccggtcga ggaccacgag
     8041 gagcgcctcg gtgtcggccg ggtgcagacc ggcggacggc tcgtcgagca cgtacacgac
     8101 gccgaagagt cccgaacgca actgggtggc gagccgcagc cgctgaagct cgccgttgga
     8161 gagggtgggg gtggcgcggt ccaggctgag gtagcccagg ccgagttcgg tgaccgtcgc
     8221 gatccgggcg acgagatcct cggtgaggac ccgcgccgtc tccgcgccct ccaccggcgt
     8281 ctccgagagg agcccggaca ggaccgtcag cggaagcgcg gccagctcgg cgatcgaccg
     8341 ccccgcgaag gtcaccgcga gcgcctccgg gcgcagccgg ctgccgccgc acaccggaca
     8401 gggcgcgctc gtcaggaagc gctccgcctt cgcccgcagc gtcgtgctct tcgagtccgc
     8461 gaaggtgcgc agcacgtacc gccgtgcact catgtacgtc ccctggtagg ggcgttggat
     8521 gcggtccgcc tcccgcaccg ggtgcacggt gacgaccggc tgctcctcgg tgaagaggat
     8581 ccactcccgg tccttcgcgg ccagctcgcg ccagggccgg tcgacgtcgt acccgagggt
     8641 gtccaggacg tcccgcaggt tcttcccctg ccaggcgccg ggccaggccg cgatggcgcc
     8701 ttcgcggatg gacaggtccc ggtcgggaac gaggagttcc tcgctcgtct cgtgcacccg
     8761 gccgatgccg tgacacgaag ggcacgcacc cgtcgccgtg ttgggggaga aggcgtcgga
     8821 gtcgaggcgc tcggcgccct ccgggtagtg gccggcccgc gagaacagca tccgcagcga
     8881 gttggagagc gtcgtcaccg taccgacgga ggagcgggcg ttcggcgagg accggcgctg
     8941 ctccagggag accgccgggg gcagcccgct gatctcgccg accgccggcg cccccacctg
     9001 atggatcagc cgccgcgcgt acggcgcgac cgattcgaag tagcgccgct gcgcctccgc
     9061 gtagatcgtc ccgaaggcga gcgaggactt gcccgaaccg gagaccccgg tgaaggcgac
     9121 gagcgcgtcg cgcgggatgt cgacgtcgac cccggcgagg ttgtgctcgc gggcgccgcg
     9181 gacacggacg tacggatcct gggggctgtc ttgcatgcgg cgatattagc tacggcttcc
     9241 tgtttgcccc ggtcgggtgg gtggggtcag gggagtcgtg ccccggtcgg atgggtgggg
     9301 ccggggggcg tgcccctgcc gcgcgccgcc ccgccggggg tcgcgcgagg cgtgtgaagc
     9361 gtccgcctgg cggacggtga atggcgaaat gtgcacgggc cgcaccactt gacgggcgcg
     9421 atcaccctcc accgcgtccc cgcgcgggcc ggctcgtcgg acccgccgcg cgaggccggg
     9481 caccgtcacc cacctcggct cgcgccccgg cgcaccgacc cgcggacacc gagccggtgg
     9541 cacggcgacg gctccccggc cgggccggag accacggaac acccgatcga agtttgaccg
     9601 gttctggcag gtctcggacg gacatcctcc ggtggattct gtagctccgc gcaatcccgg
     9661 ctcgtaggag gaaacgcatg cccgtcatct ccgccacccg taccgacgcg atcgtcaccg
     9721 cctggctcca gggcgccgag acggccttcg gcgccgacaa cccggccgga ccgctgtacg
     9781 tgggcggtgc ggccggagag gccgccctga ccgacgccac cgaggcgctg ctcaccgggt
     9841 gcagcagctg taccggttcg tggcacagct actgctgctg acgaaccgcc gtacggcaca
     9901 gcacctcacg caccacccgg ggagcccgca cgggctcccc ggccccgcgt caccacggca
     9961 ggccggatca cgggcaccag gcgtcaggag aggactcagc atgggggaac cggtggcagc
    10021 ggcccgctcg gccgacggag cgccgcccga gggatggttc gccgcaccgg tgaacacctt
    10081 cgtgggcccg ctgttcgcgg agctggacga ccggatcccg cagaccgccg ggctgaccgc
    10141 cgacgagcgg gcggtgctgc gcgaggcgac gcgcgaggcc ctcggccgca ccctgcagct
    10201 ccgcctcaac cgggtgctcc tgctggagct gagggccgcc gccctggccg acgaactgcc
    10261 cggagcggac tcggccgccc gctgggactc cttcctccgg cacgcctccg ctcccgcgtt
    10321 caccgagacc ctgcaccggc ggtacccggc tctgctcgac cgggtcttcg cctccgggcg
    10381 cctcctgatc gagggcgcgc tggaactggg cacacggctc gccacggacc gggaggccgt
    10441 cgcaggcctg ctcggcggcg acccgggccc cctgcgcggc ctggagctcg cccgcgggga
    10501 cacgcaccat ggcgggcgcg cggtggcccg ggtgctcttc gagaccggca gcgtcatgta
    10561 caagccgcgg ccgacggagg tggacgcggc gctgcgctcc ttcgtcgccg ccgtccccgg
    10621 cgccgaggac ctgggcgtgc cgagggtcgc ggtcgaggac ggctacggct gggccgaaca
    10681 cctcgggcac cactactgcc gggacgaggc ggaactcgcc cgcttctacc gtgccctggg
    10741 cggctggctg gcggtgatgc gactcctcgg cggaaccgac ctgcacgccg agaacctggt
    10801 ggcccacggc ccgatgcccg ccgtggtcga cgccgaggcc ctgttcacgc ccgacgtcga
    10861 ggttccgccg agcgggcgcg gcgacgccgt cgaccgggcg gcccggacca tccgcaacac
    10921 ggtgctgcgc accggcatcc tgccgctccg caccgacggc tacgccctcg ccggcgtgga
    10981 cctctcggcc gcgggcggtc tgcccggcca gcagccgcag atccgtgtcc cggtcatcgc
    11041 ggacggagga ctggacaccg cccgcatgga gatcggtgtc gtggacctgc cgccggccgg
    11101 caaccacccc agccccgagc ccgtgctgat ccgccactgg gaccaggtgc tgaccggatt
    11161 cgacaggctc accggggcgc tggcgaaact cgacgcgggc ggcgaactcg gcacactgat
    11221 gaaggtgttc gacggctgtc aggtccgcag gatccgacgg cccacgcaga cgtacacgga
    11281 catcggccgg atgctctggc acccggcttc gctgcacgac cccgaagccg ccctggcgcg
    11341 ggcccgggac atcctccacc gcaacgccct cgccgcgccg ggtgcgcccc gcgaacccgc
    11401 ggtgatcgac ggggagatcg cggacctgct gatcggtgac gtccccgtgt tcggggagcg
    11461 ggtggacgga cagcggctga ccgccttcct gaccgggtgg cggcaggcgg acctcacccg
    11521 cgaacgcgac accatccgca gcgcgctggt cggcgcctat ctgaacgaac ggcagctccc
    11581 cgaccgggta cggacaccgg cccggtctcc gagcgccgag gacctggacc ggcgccgccg
    11641 gaccctggcg gccgcggccg tggacacgat ctgcgcggcg gccgtgcgag gtaccgacgc
    11701 caccgcgacc tggatcagtc cggtgctcac ggactacggc tgggccgtcc gcccgctcgg
    11761 cgcggacctc tacaccggcc agggcggcgt cgccctcgcc ctcgcggagt acctgcggga
    11821 gcagcgggcg gggcgggccg acccggtggc cgacgtcgag cccgtgctgg ccggcaccct
    11881 ggaggtgctg gcctccaccg aggacaccat gccgacccgg cagctcggcg ggttcaccgg
    11941 gctcgcctcg caggtgtgga cctgggcggc cctccaccgt gtcctcggga cgcccgggct
    12001 gctcgaccgg gcccgcgcca gggccgcgct gctgaccccg gagatcgtcg ccgaggaccg
    12061 ggccctcgac gtgctcggtg gcgcggccgg ggtgatcgtc cccctgctcg acctcgccga
    12121 actcaccggc caggagcggt gggtggacgt cgccgccgaa gccgggcgcc gcctggaacg
    12181 gaccgcggtc gtcgacgacc gcggagcgcg gtggtccacg gtcatgttcc cggagggcat
    12241 cggcggattc gcccatggcg ccaccggcgc cggctgggcg ctgacccggc tcgccctctc
    12301 cgccgccggg agcacggccg accggcgtcg ctggcacgaa ctgggctccc tcgcccatga
    12361 cttcgaggag tccctgtact cgccgggcgt acgggcctgg gccgacgcgc gggtcggcgg
    12421 agaggtcgac catcccaccg cgtggtgtca tggcagcacg ggcataggcc tggccgcgat
    12481 cgatctccac gggcgcaccg gcgacccccg ccatatggac accgcgctcc gctcggcacc
    12541 ggcgggcctg cgcgagggct tcggctggag ccacaccctc tgccacggcg acctcggact
    12601 ctgggaactc ctccaccgcc tgcgcggact gacggggtac gaggggccgt ccgccgccga
    12661 ggccgacgcg gagctgctca ccggcatcga gcagcgcggt ccggtcggcg gcctcgccaa
    12721 ggaggcgttc gcaccggggc tgctcccggg gctggccgga gtggtccacc agctgctgcg
    12781 gatgcacccg gacgcccggc tgagctctcc gctcctcctg gctctcccgg ctcctacgct
    12841 gggaccgtga cacgagacaa ccggccgttg gccgtcttcg acctggacaa caccctctcc
    12901 gcgaccgccc atcgccagca cttcctggag gggcggccca agaactggga cggcttcttc
    12961 gcggcggcgt ccgacgatcc gccgctggag gagggcatcg cgctgtgccg gaaggcggcg
    13021 gaggagtgcg aggtggtcta cctgaccggg cggccggagc ggtgccgccg ggcgaccgtg
    13081 gcctggctgg cggcgcaggg cctgccggag gggcggatcc acatgcggag caaccgtgac
    13141 ttccggccgg cccgggtgac caaggtggag gtgctgcggc ggctggccgc cgaccgcgag
    13201 gtccggatgc tcgtcgacga cgacgtgctg gtgtgcgacg cggcggaggc ggctgggttc
    13261 cacgtcgtac gcgccggttg ggcggccccg tcggaggcgc tgagggacgc ccaggagaag
    13321 gagggccgta cctgatcccg ggcgtgatcc cgggcctgat cctggccctg gtccccggcc
    13381 tgatcctggt cgtgatcccg ggcctgatcc cgggattgac gccggatctg gcccagggcg
    13441 gcatggcccc gggcccggtt ccggccctcg gtcaggccgc ctcgtcctcc aggcggaagc
    13501 ccaccttcag cccgacctgg tagtgctcga tggcgccgtc gacgatgtgc ccgcggacct
    13561 gcgtgacctc gaaccagtcg aggccccgca gcgtctggga ggcgcggttg atgccgttgc
    13621 ggatggcttc gtcgacgcct tcggtggagg tcccgacgat ctcggtgacg cggtacgtgt
    13681 gattcgacat gggggccgaa ctcctctcgg tgcgtccctc caccgtgccc caggccgcgt
    13741 cggcgcgcga caggaccgcc gccgtacgac gcgcggtcga ttaccgaggg taatgatcaa
    13801 ggtctgctgt ccggaggccg gaacgggatg gtcaaggact tgaccacttc gttggtccag
    13861 accagaatcc aggccacata cccgcgcgaa caccccgttc ggtcccccca cgtcgggtca
    13921 gcccccaatg ccgcacgaac ctgtgcagaa cccgcagaag gtgacctacg tgaagaaccg
    13981 ccatctcgcc tgccccttgg cagccgccac cgcgctcgcg ctcgccgggt gcgggatgct
    14041 gccgggcggg ggccagacga agaccgtcaa catctggctc atgcgggaca gcgccagcga
    14101 ggacttcctc acacgattca ccgaggccta cgaggaggag cacaacgggg tcgacctcaa
    14161 catcaccatc caggactgga ccggcatcgg gaagaaggtc accgaggcca tcgagggctc
    14221 cggcggaccc gacgtcatcg aggtcggcaa cacccaggtc gcccagtacg ccgacaccga
    14281 gaagctctac gacctcaccc tggagtccgt acgcgacctc ggcagcgagg actggctgcc
    14341 cggtctcgcc cagccgggca gcatcggcgg ctcccagtac ggcattccct ggtacgcggc
    14401 caaccgcatc gtcatctaca acaaggacct gttccgggac gccggcatcg acaagccccc
    14461 ggccacccag gccgagtggc tcgccgacac cgagaagctc aaccgcggcg gcacccaggg
    14521 catctacctc gcgggccagg actggtacac cctctccggc ttcatctggg acgagggcgg
    14581 cgaactcgcc gtcgacaagg gcggcgagtg gaccggcgcc ctcggcagcc ccgcggccct
    14641 gcgcggcatg gacttctaca agaagctcca gtccctcggc gacggcccca aaaacgccga
    14701 cgagcagaac ccgccgcagg ccgacgtctt cgccaagggc gacgtcgccc agatcatcgc
    14761 cacgaccagc gccgtcgcgc cgatcctcaa ggccaacccg gacctcaagg acaagctcgg
    14821 ctacttcgcg atacccggca agaaggccga ccagccctgc gtcgtcttca ccggcggctc
    14881 cgacctcatc atcccggaga acgctcccca gcgcggcgcc gccctcgacg tcgtcaaggc
    14941 gttcgccggt gagaagtggc agaccgaact cgcccgcgcc atgggatacg tgcccaacaa
    15001 gaaggggctc gcctccgtcg tctccggcca ggaggcgacc gccgtcatgg cagcggccgc
    15061 cgcacgcggc cgggccaccc ccaactcccc gcagtgggcg aacgtcgagg gcgacaaccc
    15121 catcaagccg tacatgacgg ccgtcctcca gggcgaggac ccgaaggagg ccgccgagaa
    15181 ggcctcggcg gagatctcgg acacgctcgc cgaatagcat tcagcgttcg cacatccgcg
    15241 agcccccgga cggtcatgtc gaatccagcc ggtgacggaa gaagtaagga gccgggccac
    15301 tgctcacgcg gcccggtccc gcaccttccc cttccgtccg ccggaggagc ccgacatgac
    15361 cgcaccgtcg cccacgctcg ccgtccccgc cggagccgtt tccgtcgggg cggtatccgt
    15421 tcccgcccag ccccagcccc agccccaggc ccgcgccgag caggccgcgc cccggtacgt
    15481 cgtcggactc gcccgtgacc aggaggacgt acgggccgcc cagcggctgc gccaccaggt
    15541 cttcgccggc gaactgggcg cccggctcga cggccccgag cccggcctcg actccgacgc
    15601 cttcgacgcg tactgcgacc acctgctcgt ccgggacgag gccaccggcg aggtcgtcgg
    15661 cacctaccgg atcctgccgc ccgagcgggc cgccgtcgcc ggacgtctct actccgagag
    15721 cgagttcgac ctcacccggc tcgcccccgt ccgccacgac ctcgtggagg tcggccggtc
    15781 ctgcgtccac cccctccacc gcaacggcgc cgtcatctcc ctcatctggg ccggcctcgc
    15841 ccgctacatg acccggaccg gccacaactg gctcgccggc tgctgctcga tccccctcgc
    15901 cgacggcggc accctcgccg cctccacctg ggacaccgtc aaggccaagc acctcgcccc
    15961 cgaggagtac tgggtcaccc cgcacaggct ctggaacgcc gacggcatcg cccgccccga
    16021 aggccgcacc gaactcccgc ccctcctgcg cggctacctc cgactcggcg cctgggtctg
    16081 cggcgccccc gcccacgacc ccgacttcgg cgtcgccgac ctgtacgtcc tgctctccct
    16141 gcgccgcacc aacccgcgct acctcaacca cttcctgtcg ctcgcccccg ccccgtgacc
    16201 ggctccacgg caccctcgcc gtggctcccc acggcgccct gcaccccggg ccgctgcgcc
    16261 gcccacccgg acccggcggc cgaccgcacg gtcctcgcgg cgggcgccgc cctggcctcg
    16321 gcgcggctgg ccgccgggat cggcgcggtc ctcctcggcg tcctgtgcgt gccggccgcc
    16381 cgactcctgc cgacgccggt gcggctcgcc ctcgtccggt actgggtacg ggccgtggtc
    16441 cgcgccttcg gcgtgcgcgt ccgcttcgcg gggctccccg ccccggccga caggcccctc
    16501 ctcgtcgtcg ccaaccacgt ctcctggctg gacatcccgc tcctcgcggc cgtcctgccc
    16561 ggccggatgg tcgccaagac cgaggtccgg cagtggccgg tcctcggcgc gctcgccgtg
    16621 ctcggtggga ccctcttcat cgaccgggac cggctcaggg ccctgcccgg caccgtgcgg
    16681 gcgatggccg cggtgctcgc gggcggcggc cgggtgatcg tcttccccga gggatcgacc
    16741 tggtgcggac gggccggggg ccgcttccgg ccggccgcgt tccaggccgc gctggacggc
    16801 ggggccgacg tccagcccgt acggatcgac taccggccca ccgacgccgc cgcctacgtc
    16861 ggggacgacc cgctgggcgc ctccctgtgg cggctcgcgg ccacccgcgg agtcaccgcc
    16921 gacgtgacga cactggaacc gataccgggc gcccggtacc cggaccgccg ctccctggcc
    16981 gccgcggctc agcgggccgt cgcgagcgag agtgcgaacc ggccctcttc gtccgtccac
    17041 cagcgggaca gatcgagccc ggcctccgcc agctcgtccc gcactcccgc ctgacggaac
    17101 ttcgccgaca cctccgtccg tacctcctcg cccgcggcga agggcaccac gaggtccagc
    17161 tccgggatct tcaccgtgag cgcatgccgc gcgcgcagcc gcatctcgat ccactcgcgg
    17221 tcccggtccc agaccgccac gtggtcgaag tcgcccggat ccgcgtcggc gccgagctcc
    17281 cggtcgatca cggacagcac gttcttgttg aacgccgccg tcaccccggc cgcgtcgtcg
    17341 taggcggcga cgagcgtctc ctcgtccttc accaggtccg tgccgagcag cagcgcgtcg
    17401 cccggggtga gcatcgcccg gaccgagcgc aggaaggtcc gccgctcggc ggggagcaga
    17461 ttgccgatcg tgccgccgag gaacgccacc aggcgcggac cgggcatccc cggcagcgcg
    17521 agcccccggg tgaagtcggc gaccagggcg tgcacccgca gctcgggacg gtccgcgagc
    17581 agcgactcgg ccgccccggt cagcgcggac tcgctcacgt ccacgggcac gtagccgtcc
    17641 agaccgggaa ggagcgcgtc gatcaggaac cgggtcttct cggaggatcc ggaacccagc
    17701 tcgaccaggg tcctggcccc ggtcgccgcg gcgatctccg gcgcccgggc gatcaggatc
    17761 tcccgctccg cccgggtcgg gtagtactcg ggcagccggg tgatctcctc gaacagctcg
    17821 ctgccccggg cgtcgtagaa ccacttcggc ggcagggtct tgggggagcg ggacagcccg
    17881 tggaggacgt cggtgcgcag atcggcgccc gcggcgtccg gggcgagggt acgggtcagc
    17941 tggaacgggc tcacgcggac ggctccttga gcggggtgag ggtgacgtcg ccgcggtcgg
    18001 cggtcacgag cgtgtgctcg gggacctcgc gccaccgcgg atcgtcgtcg tacggttcgg
    18061 aggccacgac cacgcggtcg gggcccgtca ggtaccagag gctgttcccc catctcgtcg
    18121 cggtgacggt cgtgccgtcg gtgagcagca cgttcagcga ggagcccgga gccgcggcgg
    18181 cggcctcgcg cacggtgtcg gccagggccg tccccggggc gtccccggcc cgcagccggt
    18241 gcagcacgag cgcccacagg agcgccgagt cggtgcgcgc ctccagctgc agcagcgcct
    18301 cggccgggag tgcgccggcc agggcggcca gggactcggc ccagccggtg acggcgccgt
    18361 tgtggctgaa cagccagggg cctgcggtga acggagcggt cgctgcctcc ccgtcggcgc
    18421 cggccagcgt ggcgccccgt accgccgcga gcagcgcccc ggtgcggacc acccgggcga
    18481 ggtccgcgaa ggagaggtcg ccccagatgg gcgccgcgcg ccggtagcgc gcgggcaccg
    18541 gatcgccctc cgcgtaccag cccaccccga agccgtcggc gttcacgaca ccgctcgtct
    18601 ggtgacgcgg ttcccaggac tggcgcagca gggcgtgctc gggccggacc agcagctctc
    18661 ccagcgccac cggcccgccc acgtaggcga gatgacggca catcagccga actccgcggt
    18721 ccgcgccgta cggaagcccg agaagatctg gcgccgcacc ggcaggtccc agttgcggaa
    18781 ggtgccccgg caggcgaccg ggtccaccgc gaacgagccg ccccgcagca ccttgtgctc
    18841 gggcccgaag aaaacctccg agtactcctt gtacgggaag gccgtgaagc ccgggtaggg
    18901 caggaagtcg ctcgccgtcc actcccacac gtcaccgatc aactgccgca ccccgagcgg
    18961 cgaggcgccc tccggatagc tgcccgcggc cgccggccgc aggtgccgct gcccgaggtt
    19021 cgcgtgctcg gggccgggat cggcgtcgcc ccacggatag cggcgcgagc gacccgagac
    19081 cgggtcgtgg cgggcggcct tctcccactc ggcctcggtg gggagccggc gtccggccca
    19141 gcgcgcgtag gcgtccgcct cgtaccaact cacgtgcagg accggctcgt ccaggggtac
    19201 gggctcggtc accccgaagc ggcggcgcag ccactgcccg ccgtcccggc gccagaacag
    19261 cggcgccccg atgccgtgct cccggatctg cgcccagccc tcgggccgcc accagcgccg
    19321 gtccgtgtac ccgccgtccg ccatgaaggc cagataggcg ccgttggtga cgggggtggt
    19381 gtcgacgaag aaggccggaa cgatccgggc gtgggccggg cgttcgttgt cgagggccca
    19441 cggctcttcg gaggtgccca tggtgaacgg gccgcccggg acgaggactt cgggagggag
    19501 cggcccggat cgcggggtcg gtggcggggg cgcggtgagc gccgccggac cccggcgcag
    19561 ctgatgggtg atcaacatgg tctcgtcgtg ctgctgttcg tgctgggcga tcatgccgaa
    19621 cgcgaagccg tcgtcgagca gcggccgccc ctccagcggg gcgctctcca gtacgtcgag
    19681 gatccgcagg cgcacgtccg ccgcataggc gcgggcctcg cccggcggga gcagcgggag
    19741 cgaggggcgg ctggcgcgcg ggtgctcgaa ggcgtcgtag agggagtcga tctccggccg
    19801 cagcgcgtcc cgcccggcga cggcccgcca cagccactgc tcctcctggt tgccgatgtg
    19861 cgccaggtcc cagaccagcg gcgacatcaa gggcgagtgc tgggcggtga gttcctcgtc
    19921 gtcgacgcag gaggtgagca gggccgtgcg ctcgcgcgcg acggtcaggg cggccagggc
    19981 ccgcgcacgc agcgcctccg gatcgacggg atcgatggga tcgacgggat cgatcgcggg
    20041 ggcctgttcg gtcccggtgg cccgttgggt cccggtcatg acgtcaccac ctgaagctcg
    20101 tcggccgggc agcccccggg gatcacgtac ctctcctgga aggcggcgac ggaccgtcgc
    20161 acctcctcgc tcgccccgat ccggggcagc gccgcgaggg cggccgagaa gaccgcgcgg
    20221 gcggcggtgt gcagcccggg atcggtgagg ccgtcacgcg ccgcagccag ccacagcgga
    20281 ttgcgcggcg ccggccccgg accggcccgc tccgcgaggg gttcgaccgc ccggtggacg
    20341 gcctccgccg cctccgggtc ctcgaagacg gccgtcgtca cggccaccgg caccatccag
    20401 ccgtccgggc cgggctgcgc gtcgatcatc cgcagttcca gatggccgcg cggccggacc
    20461 ggcgggaaga gcgtcgtcac gtggtagttc agatcgtcga ggcccgcggg ccgggggagc
    20521 cccgtgcgca gccactcacg gaaggtcagc ccctccggca ccgcccacgg cccctcgtcg
    20581 gcccgcacgc acagcaccgg ggtgtccagg acgtgcgcgg tccactcgtc gcggggtttc
    20641 ccgtccggcg gcggcgcgag ggcccgccgc gggtcgaggt tcgtccacag cgcctggcgc
    20701 gtcgagcgcc agccggtccg acggccgccg tgcacggggg agttggcgaa gaccgccacg
    20761 agcaccgcgc cgaggagatg agccagccgc cagcgccggt ggtagccgag cggacccggc
    20821 tcgtcgagcc cggcgtcgag acagacctgc acggaggccg agtcgcacat catcgcccgc
    20881 ccggccggcc ccgtgcggtc gagcgcgatc tccatggcgt cgtaccgcgg ctcgtggagc
    20941 acccggccgc gcggcgcgtg ccacgggtcc accccgtagc cgttcagggt gagaccgagc
    21001 ggtccgagcg cctcccgcac cgcgcgcaga tcggcggcga gcgagtcgag acactccatg
    21061 agcgacccgg ccggacgcga actgagctcc agctgaccgc ccggttcgaa ggtgagcgac
    21121 gagaccagcg gcagggatcg tacggtgtcg agcgcggcgg ccagtctcgg cggccgtacg
    21181 ggcagacgcg ggtcgcgcag atcatggacg agccactcca gctcggcccc gaccgtgcgg
    21241 ggcggacctg tcttgaaaca gatgccgcgc agcagttcct ccgcctccga ctcggtgagt
    21301 ggggggccgc cacgcggtgt gccgctcgct gccatccgtg cacctcctga tccactggac
    21361 aggcccggaa gggctggccc cggatgccgc tgcttccacc taaagccact gccgacccgc
    21421 gtgcaagagc gcctcacagt gaccgcacgc gccccctgtg ccccccttgg cccgaaactt
    21481 cccccggcgg tggaaacctc ggaaaatccg ttgtccccgc ccgggggaaa cgatcatgct
    21541 ggcggtcatg agtgcacgac tgcgcgagat cgcccggaag accgaggaga tcgtggccgc
    21601 gggcggatac cgggcccccg acggccggac cgtctccctc gcggaagacc tgaccgccgc
    21661 cctggccgga acccgtctcc acggccccga gcccgtcccc gtcacccccg acaccgaccg
    21721 cacggccacc ctggacgtca cgggggagag cagcctggcc gccgcgcgcc ggatggtctc
    21781 cgccgacccc gcccgcccgg tcgccgtact gaacttcgcc tccgcccgca accccggcgg
    21841 cggctacctc aacggcgccc aggcccagga ggaggcgctc tgccgggcct ccgccctcca
    21901 cgccacgctg ctgcgcgccc ccgactacta cgcccaccac cgtgcggacc cggacgtgtt
    21961 ctacaccgac cgggtcatcc actcgccccg ggtcccggtc ttccgcgacg aacgcggcgc
    22021 gctgctcgac gagccgttca cggtcggctt cctcacctcg cccgcaccca acgcgggcgt
    22081 cgtccgccgc cgcacccccg aacgggccgc gcagctgccg gcggccctgg ccacccgcgc
    22141 cgaaagggtc ctggagacgg cggccgcggc cggctaccgg cggctcgtcc tcggagcctg
    22201 gggctgcggg gtgttccaga acgacccgac ggtggtcgcc ggtgccttcg gagcgctgct
    22261 caggggcgac ggccggttcg ccggccactt cgaggagatc gtcttcgccg tcctggactg
    22321 ctcctccggc gcgccgacgc tcgccgcctt cgccagggtc ctcgccagcc ccgtctgaca
    22381 tgcggctttc gtccccccgt gcgaggctga gggcatacgg accacagtcc gagacccctt
    22441 catgggaggc acgatcgtgg gcaagaaaca gacccggacc aaccgaggcg cccgtaccgg
    22501 cggtcatgag caccgcaccg aggcggccgc gaaggaaaag acggcggcga cccccacgag
    22561 agagccccag atgcccctcg tggagcacgc gtcccaccgc aaggaacgga agttcggcca
    22621 caactgaggc ccggacgcag ccgacgccga agcgcggctg acgccaggaa gcaaccgagg
    22681 ccggcgcaca cctgaggcca ggcctccacc caggccaggg gatcgcacga acgggcccgg
    22741 cgccgtgacg gcaccgggcc cgtcgcgcgg ggccgaccgc atcggccgcc ccgcgcatgc
    22801 actcgccgcg gcggcgacac catgtcggct gcaccgcgtc ggctactccg
//
