LOCUS       NZ_CP059991            10951 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptomyces gardneri strain ATCC 15439 chromosome, complete genome.
ACCESSION   NZ_CP059991
VERSION     NZ_CP059991.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces gardneri
  ORGANISM  Streptomyces gardneri
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9054805)
  AUTHORS   Kim,W., Hwang,S. and Lee,N.
  TITLE     Genome-scale analysis on the transcription unit architecture of
            Streptomyces venezuelae ATCC 15439
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9054805)
  AUTHORS   Kim,W., Hwang,S. and Lee,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Biological Sciences, KAIST, 291 Daehak-ro,
            Yuseong-gu, Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 6.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: CP013129
            Genome Coverage                   :: 187.8x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015710995.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 17:12:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,199
            CDSs (total)                      :: 8,101
            Genes (coding)                    :: 7,918
            CDSs (with protein)               :: 7,918
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 184
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 184
            Pseudo Genes (frameshifted)       :: 70 of 184
            Pseudo Genes (incomplete)         :: 147 of 184
            Pseudo Genes (internal stop)      :: 16 of 184
            Pseudo Genes (multiple problems)  :: 48 of 184
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:23:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6859710
            Orig. end                         :: 6870661
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059991.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10951
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="24"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10951
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10951
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5951](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5951
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    complement(514..528)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.29"
                     /tool="antismash"
     gene            613..1002
                     /db_xref="GeneID:95693052"
                     /locus_tag="H4W23_RS30990"
                     /old_locus_tag="H4W23_30970"
     CDS             613..1002
                     /codon_start=1
                     /db_xref="GeneID:95693052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037145.1"
                     /locus_tag="H4W23_RS30990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_30970"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_055640743.1"
                     /transl_table=11
                     /translation="MFHTGLRSGTAVKAAEEAGPDAELYFQRCRWCHTTTFQRLLCPTC
                     GSTELSPELSEGEGVISVRRGVAAADADLWPVYMTEGFTVRCRVDGPLHAVRPGVRVKV
                     SSGVGTTGRRPVVRLCEEVPLDGWI"
     gene            complement(1082..2038)
                     /db_xref="GeneID:95693053"
                     /locus_tag="H4W23_RS30995"
                     /old_locus_tag="H4W23_30975"
     CDS             complement(1082..2038)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238294.1"
                     /locus_tag="H4W23_RS30995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_30975"
                     /product="electron transfer flavoprotein subunit alpha/FixB
                     family protein"
                     /protein_id="WP_055640742.1"
                     /transl_table=11
                     /translation="MAEILVLVDHADGAVRKPALELLTLARRIGEPSAVVLGAGEAAAS
                     IAATAGEYGAATVYVADGAEFTDQLVVPKVDSLTQLAKEKGAAAVLVTSSGEGKEIAAR
                     VALRLGSGLITDAVELEAGENGPVATQSVFAASYQVRSTVSHGVPVITVKPNSAAPEAA
                     PAAGTVENVAVAFTGNAAKVVSRTPRVSTGRPELTESAIVVSGGRGVGAAEGFAVVEKL
                     ADSLGAAVGASRAAVDAGWYPHANQVGQTGKQVSPQLYVAAGISGAIQHRAGMQTSKTI
                     VAVNKDAEAPIFDLVDYGVVGDLFEVLPQLTDEIGAR"
     gene            complement(2078..2863)
                     /db_xref="GeneID:95693054"
                     /locus_tag="H4W23_RS31000"
                     /old_locus_tag="H4W23_30980"
     CDS             complement(2078..2863)
                     /codon_start=1
                     /db_xref="GeneID:95693054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262570.1"
                     /locus_tag="H4W23_RS31000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_30980"
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="WP_055640741.1"
                     /transl_table=11
                     /translation="MTLKIAVCVKYVPDATGDRGFADDLTTDREAVDGLLSELDEYAVE
                     QALRISEESDDAEVTVVTVGPDDAKDALRKALSMGADKAVHVNDEDIHGSDVIATSAIL
                     AKALEKTGFDLVVCGMASTDGTMGVLPALLAERLNVPQVTLLSEVSVDGDTVKGRRDGD
                     SATELLEAPLPAVVSVTDQSGEARYPSFKGIMAAKKKPVEELDLDDLDIDADEVGLAGS
                     WTLVDAVAARPARTQGTIVTDEGDGGKQLAAFLATQKFI"
     gene            complement(2892..4058)
                     /db_xref="GeneID:95693055"
                     /locus_tag="H4W23_RS31005"
                     /old_locus_tag="H4W23_30985"
     CDS             complement(2892..4058)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037148.1"
                     /locus_tag="H4W23_RS31005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_30985"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_099054343.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8.6e-30, bitscore:
                     102.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7.8e-28, bitscore:
                     95.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.3e-49, bitscore:
                     167.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKDFDLYRPSEEHDMLRESVRALAEAKIVPFAAAVDEEGRFPQE
                     ALDALVANDLHAVHVPEAYGGAGADALATVIVIEEVARACGSSSLIPAVNKLGSLPVIL
                     SGSEELKAKYLGPLAKGDAMFSYALSEPDAGSDAAGMKTRAVRDGDFWVLNGVKRWITN
                     AGVSEYYTVMAVTDPDKRSKGISAFVVEKSDEGVSFGAPEKKLGIKGSPTREVYLDNVR
                     IPADRMIGAEGTGFATAMKTLDHTRVTIAAQAIGIAQGALDYAKGYVKERKQFGKPIAD
                     FQGVQFMLADMAMKLEAARQLTYAAAAKSERVSAGGDKEDLTFFGAAAKCFASDVAMEV
                     TIDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP"
     gene            complement(4210..4869)
                     /db_xref="GeneID:95693056"
                     /locus_tag="H4W23_RS31010"
                     /old_locus_tag="H4W23_30990"
     CDS             complement(4210..4869)
                     /codon_start=1
                     /db_xref="GeneID:95693056"
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037149.1"
                     /locus_tag="H4W23_RS31010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_30990"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_055640740.1"
                     /transl_table=11
                     /translation="MAQQARAIKTRRAILEAAATVFAERGYERTTIGEILVRAGVTKGA
                     LYFHFASKEDLALGVLDAQMLDEPMSPQPIKLQELADQAFLLGHRLQRDPLVRASVALA
                     LDSGATGVDRAAPFKAWIDQVSEILTVAKTRGEILGHVDVSDTAELFSGAYAGIQTMSQ
                     ILRNRNDLNHRVSVLLRYLLPSICTPALLTGLRLNEDRAEQLAAEYDASQSRREEQ"
     misc_feature    4920..4933
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.47"
                     /tool="antismash"
     gene            5001..5951
                     /db_xref="GeneID:95693057"
                     /locus_tag="H4W23_RS31015"
                     /old_locus_tag="H4W23_30995"
     CDS             5001..5951
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693057"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037150.1"
                     /locus_tag="H4W23_RS31015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_30995"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_055640739.1"
                     /sec_met_domain="AfsA (E-value: 4.9e-27, bitscore: 92.7,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQEWRGATAHVPGEYVHRADPADIFPTGWTRLAENRFSVSARWP
                     AAHPFFSPVAGDRHDPVLVAETIRQATMLVCHAELGVPLDAQFVMWGLNYAADPEALAV
                     DGLSSDVTVDLVCSDVIRRGGGLRSMRATVVLTRDGRHLATGSALTRCTSALAYRRIRG
                     ERLAALGRPVPLIPGVAPQLVGRENLKDVVLGVGARPGQWQLRINTGHTTLFRRPNDHV
                     PGMVLLEAARQAATLTTGSRAFLPAAMESSFSRYAELDSPCWIEAQAVPGADPSTTTVL
                     VAGRQDGHEVFRSVLTSPSRDLAVVGGGLSSRLAG"
     misc_feature    5005..5019
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            5966..6958
                     /db_xref="GeneID:95693058"
                     /locus_tag="H4W23_RS31020"
                     /old_locus_tag="H4W23_31000"
     CDS             5966..6958
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (6-200). E-value: 1.8e-09.
                     Score: 29.0. Matches aSDomain:
                     nrpspksdomains_H4W23_RS31020_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GeneID:95693058"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037151.1"
                     /locus_tag="H4W23_RS31020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_31000"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_055640738.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.8e-08, bitscore:
                     32.1, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.9e-06,
                     bitscore: 25.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPRVLITGTTGFVGSRVAALAATRPEPGHLRLLTRRLLPPATTP
                     GTTPAATLATEPAPVTETVTGDLRDADSLRRACEGVDVLIHCASAIGGDEELARSVNDE
                     GTRALVEAAVRAGVSRIVSLSTASVHGRGPFRAAAPGTLPLAPGSATSRTRAAGERHVM
                     EAGGAVLRPHLVYGAGDRQLIPGLIRLLELLPGPLDAGASLHSLIDVDSLAGALLGAAF
                     SPRTEAGAYYVNHPEPVPVAELLAPCEELLVGQAGQAGRSRAAAVDLAEAYELLAGHPF
                     GRHHLAMLATDHWFADDRPWEELGGDPGPGFTAGFAAHTWWYRNLLDPS"
     aSDomain        5984..6565
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_H4W23_RS31020_NAD_binding_4.1"
                     /evalue="1.80E-09"
                     /label="H4W23_RS31020_NAD_binding_4.1"
                     /locus_tag="H4W23_RS31020"
                     /protein_end="200"
                     /protein_start="6"
                     /score="29.0"
                     /tool="antismash"
                     /translation="ITGTTGFVGSRVAALAATRPEPGHLRLLTRRLLPPATTPGTTPAA
                     TLATEPAPVTETVTGDLRDADSLRRACEGVDVLIHCASAIGGDEELARSVNDEGTRALV
                     EAAVRAGVSRIVSLSTASVHGRGPFRAAAPGTLPLAPGSATSRTRAAGERHVMEAGGAV
                     LRPHLVYGAGDRQLIPGLIRLLELLPGPLDA"
     gene            7034..7798
                     /db_xref="GeneID:95693059"
                     /locus_tag="H4W23_RS31025"
                     /old_locus_tag="H4W23_31005"
     CDS             7034..7798
                     /NRPS_PKS="Domain: PKS_KR (7-186). E-value: 3.2e-10. Score:
                     32.2. Matches aSDomain:
                     nrpspksdomains_H4W23_RS31025_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GeneID:95693059"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037152.1"
                     /locus_tag="H4W23_RS31025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_31005"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_055640737.1"
                     /sec_met_domain="adh_short (E-value: 1.1e-29, bitscore:
                     102.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPLTGRTAIVTGASRGIGRGIAERLARDGAFVAVHYGSNGEAAR
                     ETVERIEESGGRAFAFRAELEAPDAVDTFYAALDAGLAEHGADHGFDILVNNAGASGSG
                     RIHELTTEVFDRLFAINVKAPLFLIQRGLGRLRDGGRIVNVSSAATRIAFPDSVTYAMT
                     KGAVDTMTLALAKELGPRGITVNAVAPGFVATDMNARRRATPEASAALAAYSVFNRLGT
                     PADIADIVGFLVSDDARWITGQYVDATGGSAL"
     aSDomain        7055..7591
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_H4W23_RS31025_PKS_KR.1"
                     /evalue="3.20E-10"
                     /label="H4W23_RS31025_PKS_KR.1"
                     /locus_tag="H4W23_RS31025"
                     /protein_end="186"
                     /protein_start="7"
                     /score="32.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAIVTGASRGIGRGIAERLARDGAFVAVHYGSNGEAARETVERIE
                     ESGGRAFAFRAELEAPDAVDTFYAALDAGLAEHGADHGFDILVNNAGASGSGRIHELTT
                     EVFDRLFAINVKAPLFLIQRGLGRLRDGGRIVNVSSAATRIAFPDSVTYAMTKGAVDTM
                     TLALAKELGPRGITVN"
     CDS_motif       7061..7126
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_H4W23_RS31025_0001"
                     /evalue="1.70E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="H4W23_RS31025"
                     /protein_end="31"
                     /protein_start="9"
                     /score="14.3"
                     /tool="antismash"
                     /translation="IVTGASRGIGRGIAERLARDGA"
     gene            complement(7838..8488)
                     /db_xref="GeneID:95693060"
                     /locus_tag="H4W23_RS31030"
                     /old_locus_tag="H4W23_31010"
     CDS             complement(7838..8488)
                     /codon_start=1
                     /db_xref="GeneID:95693060"
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268979.1"
                     /locus_tag="H4W23_RS31030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_31010"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_055640736.1"
                     /transl_table=11
                     /translation="MTKQERGTRTRDALIRSAAGEFHQHGYALATLSAISVGAGVSPGA
                     LHFHFENKAAIAEAVEDAACTTLRRTARIAYGHRSNALQNLVDTTHALARLFREDIVVR
                     AGFRLSCANHCRTELNLRQEWQSCVQQRLAEAADEGLLGGGAVRQQDLARTIVAATIGL
                     VTLSQDSGEWLSPHAVTGLWRTLLPALTAPEAHAGLEPEGTPAVIIHSLAPVG"
     misc_feature    complement(7943..7945)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8634..8650
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.79"
                     /tool="antismash"
     gene            complement(8776..9867)
                     /db_xref="GeneID:95693061"
                     /locus_tag="H4W23_RS31035"
                     /old_locus_tag="H4W23_31015"
     CDS             complement(8776..9867)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95693061"
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037365.1"
                     /locus_tag="H4W23_RS31035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_31015"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_079037359.1"
                     /transl_table=11
                     /translation="MSVHPGELPETLDNAPVAPDSRTADSATGFTELDLALVDALQAAP
                     RAPWTRIGRALGVDATTAARRFERLRAGGLAWVTAYDAAKTATVAYVEVRCRPRAFDRV
                     SAAVTALPWVFGVDETAGDFDLFLSVAAPDLPSLGRAVHGGIGGLRGVRSTRTRLGITL
                     YGEGRDWRMRAMNPAERAGLGGPPGPRPRSYSTHLHERPGPQDQALIGALGGDGRLGYA
                     ELGARTGMSEHTARRRLQRMIRDGDISLRCDLAHPLAGLSTMVVYRTSVPHALLEQTGN
                     ALARLEQVRMCVSVSGPYNLLVLVWLHGLGAVDPFEALLAERFPALEVRDRTVSLFSRK
                     RMGWLLDEQGRAEGRVPLGLPEL"
     misc_feature    9867..9880
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(10280..10295)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    complement(10660..10676)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.96"
                     /tool="antismash"
ORIGIN
        1 agcgccgact ccgacgaccc gatcgtgcgc gtctgcgacg ccgcccggct cgtcatgcgg
       61 atgtacgccg agaaccccac cttctccgtg cagcgctacc gcctcacccg cgaggtgacc
      121 ggactgcgga cgtacgagct ctcggtcgtc tggcggtacg agaagaccct cggcgactat
      181 ctgcgcaccc gctgggccga ccgccgggac ggcaccctgc gcgccaacgt ggtcgcggcg
      241 gccgtcgtcg ccgcccacaa ccacgccctg cgccactggc tgcgctcggg cggcgagggc
      301 gacccgctgg cggaggtgga ccaggccctg gagttcgtcc gggcgacctg gagcccggac
      361 gcggtggcgg acgcgcccac cgaggagaac gaggacgtcg tggtggtcat caccaagcgg
      421 tccaccccga tgtggcgcgt ggtgcgcgag gtggagtcga gcctcggcga gggctgaccg
      481 tatttctcgt catcgctcgt cagggatccc ggtatctcta attgagggaa ctcaggtctt
      541 tatttgatgg cactcagtgc catatctttg ctccatgcac ggtcgagccg ccgagtgcaa
      601 ggagaaccca tcgtgttcca caccggactg agaagcggga ccgccgtcaa ggccgccgaa
      661 gaggcgggcc ccgacgccga gctctacttc cagcgctgcc gctggtgcca caccacgacc
      721 ttccagcgac tgctctgccc gacctgcggg tcgaccgagc tgtcgcccga actcagcgag
      781 ggtgagggcg tgatatccgt acgccgcggg gtcgccgcgg ccgacgcgga cctctggccg
      841 gtgtacatga cggagggctt cacggtccgc tgccgcgtcg acgggccgct gcacgcggta
      901 cgccccggcg tccgggtgaa ggtctcctcg ggcgtcggca cgaccggtcg caggccggtc
      961 gtgcggctct gcgaagaggt cccgctcgac ggctggatct gacacgacgc gcacgaagaa
     1021 ggggcggtgg gtggcacaga gtgccaccca ccgccccttc tcgtgtcggg cgacggaacg
     1081 gtcagcgggc gccgatctcg tccgtcagct gcggcagcac ctcgaagagg tcgccgacca
     1141 cgccgtagtc cacgaggtcg aagatcgggg cctcggcgtc cttgttgacc gccacgatcg
     1201 tcttcgacgt ctgcatgccc gcccggtgct ggatcgcacc ggagatgccc gccgcgacgt
     1261 acagctgcgg cgagacctgc ttgccggtct ggccgacctg gttggcgtgc gggtaccagc
     1321 cggcgtccac ggcggcgcgg gaggcgccga cggccgcgcc gagcgagtcg gccagcttct
     1381 cgacgaccgc gaagccctcg gccgcgccga cgccacggcc gccggagacc acgatcgcgg
     1441 actcggtcag ctcggggcgg ccggtggaga cgcgcggggt gcgcgagacg accttcgcgg
     1501 cgttgccggt gaaggcgacg gcgacgttct cgaccgtgcc ggcggccggg gcggcctccg
     1561 gggcggcgga gttcggcttg acggtgatga ccgggacgcc gtgcgagacc gtcgagcgca
     1621 cctggtacga ggcggcgaag acggactggg tggcgaccgg gccgttctcg ccggcctcca
     1681 gctccacggc gtcggtgatc agaccggagc cgaggcgcag cgcgacgcgg gcggcgatct
     1741 ccttgccctc gccggaggag gtcaccagga cggcggcggc ccccttctcc ttcgcgagct
     1801 gggtcagcga gtcgaccttg gggacgacca gctggtcggt gaactcggcg ccgtccgcga
     1861 cgtacacggt ggccgcaccg tactcgccgg cagtggcggc gatcgaggcc gcggcctcgc
     1921 cggcgccgag cacgacggcc gagggctcgc cgatacggcg ggccagggtc agcagttcga
     1981 gggccggctt gcggaccgca ccgtcggcgt ggtccacgag aaccaggatc tcagccatga
     2041 ttcattgctc ctgagtgggt gtctggctga cggtgggtca gatgaacttc tgggtggcga
     2101 ggaaggccgc gagctgcttg ccgccgtccc cctcgtccgt gacgatcgtg ccctgcgtac
     2161 gggccgggcg agcggccacc gcgtcgacga gggtccagga cccggcgagg cccacctcgt
     2221 cggcgtcgat gtccaggtcg tcgaggtcca gctcctcgac cggcttcttc ttggcggcca
     2281 tgatcccctt gaaggagggg tagcgggcct cgccggactg gtcggtgacc gacacgacgg
     2341 ccggcagcgg ggcctccagg agctcggtcg cggagtcgcc gtcgcggcgg cccttgaccg
     2401 tgtcgccgtc gaccgagacc tcggagagca gcgtcacctg cggcacgttc agccgctcgg
     2461 cgagcagggc cggcaggacg cccatcgtgc cgtcggtcga ggccatgccg cagacgacca
     2521 ggtcgaagcc ggtcttctcc agggccttgg ccaggatcgc ggaggtggcg atgacgtcgg
     2581 agccgtggat gtcctcgtcg ttgacgtgga cggccttgtc ggcgcccatg gacagcgcct
     2641 tgcgcagcgc gtccttggcg tcgtccgggc ccacggtcac gacggtgacc tcggcgtcgt
     2701 ccgactcctc ggagatgcgg agggcctgct cgaccgcgta ctcgtccagc tccgagagca
     2761 ggccgtcgac ggcctcgcgg tcggtcgtca ggtcgtcggc gaaaccgcgg tcgccggtcg
     2821 cgtcggggac gtacttcaca cagactgcga tcttcagagt cacggcctgt ctcctttcga
     2881 agggctggtg gttacgggag gttgcgggcc atgacgatgc gctggacctg gttggtgcct
     2941 tcgtagatct gggtgatctt ggcgtcgcgc atcatgcgct cgacggggta gtcgcgggtg
     3001 tagccgtagc cgccgaggag ctggacggcg tcgatggtga cctccatggc gacgtcggag
     3061 gcgaagcact tggccgcggc gccgaagaac gtgaggtctt ccttgtcgcc gccggcggag
     3121 acgcgctcgc tcttggcggc ggcggcgtag gtgagctggc gggcggcttc gagcttcatg
     3181 gccatgtcgg cgagcatgaa ctggacgccc tggaagtcgg cgatgggctt gccgaactgc
     3241 ttgcgttcct tgacgtagcc cttggcgtag tcgagggcgc cctgggcgat gccgatggcc
     3301 tgggcggcga tggtgacgcg ggtgtggtcg agggtcttca tcgcggtggc gaagccggtg
     3361 ccctcggcgc cgatcatgcg gtcggcgggg atacggacgt tgtcgaggta gacctcgcgg
     3421 gtcggggagc ccttgatgcc gagcttcttc tccggggcac cgaaggagac gccctcgtcg
     3481 gacttctcca cgacgaaggc gctgatgccc ttggaccgct tgtcggggtc ggtgacggcc
     3541 atcaccgtgt agtactccga gacaccggcg ttggtgatcc accgcttcac gccgttgagg
     3601 acccagaagt ccccgtcgcg caccgcgcgg gtcttcatcc cggccgcgtc cgagcccgcg
     3661 tcgggctccg agagggcgta ggagaacatc gcgtcgccct tggccagcgg gcccaggtac
     3721 ttcgccttca gctcctccga gcccgacagg atcaccggca gcgagcccag cttgttcacc
     3781 gccgggatca gcgaggagga accgcacgcc cgcgcgacct cctcgatcac gatcaccgtc
     3841 gccagcgcgt ccgcccccgc gccgccgtac gcctcgggga cgtgcaccgc gtgcaggtcg
     3901 ttggcgacca gcgcgtccag cgcctcctgc gggaaccggc cctcctcgtc caccgcggcc
     3961 gcgaacggaa cgatcttcgc ctccgccagc gcacgcaccg actcccggag catgtcgtgc
     4021 tcctcggagg gccgatacag gtcgaagtcc ttgcccatga tgtggagctc ccctagacgc
     4081 ttgtggcact gagtaccctc agcaaaacac actcagtgcc atgacgccag agcgccccga
     4141 cgctgttccg cgtcggggcg ctgatgcgac cgtgtggtcg gttttgttta acggagggtg
     4201 tacgcggtgt tattgctctt cgcggcggct ctggctcgcg tcgtactccg ccgccagctg
     4261 ctcggcgcgg tcctcgttca gccggagacc ggtcagcagg gccggcgtac agatgctcgg
     4321 caggaggtac ctgagcagca cggacacccg gtggttcagg tcgttgcgat tgcgcaggat
     4381 ctgggacatc gtctggatcc cggcgtacgc gccggagaag agctcggccg tgtcggacac
     4441 gtccacgtgg ccgaggatct cgcccctggt cttcgcgacc gtcaggatct ccgacacctg
     4501 gtcgatccac gccttgaacg gcgccgccct gtcgaccccg gtggcaccac tgtccagggc
     4561 cagcgcgacg ctcgcccgga cgagggggtc gcgctgaagc cggtgaccga gcagaaaggc
     4621 ctggtccgcg agctcctgga gcttgatcgg ctgcggggac atcggctcgt cgagcatctg
     4681 ggcgtcgagc acaccgaggg cgaggtcttc cttggaagcg aagtggaaat acagcgcccc
     4741 cttggtgacc ccggcgcgca ccaggatctc cccgatggtc gtccgctcgt agccacgctc
     4801 ggcgaagacc gtggcggccg cctccagaat cgcccgtcgg gtcttgattg cacgcgcttg
     4861 ctgcgccaag gcgccgcctc ctgctgtctc gctgtctgtg ctcaccgtgt gacgtgatgc
     4921 gttgaaaaga aaaccgggct gtacgtattc tatgttgggc ggacacatcc gctcaggggt
     4981 gtgggacgca agggggatcc atggatcagg agtggcgagg agcgacggcg cacgtccccg
     5041 gggagtacgt ccaccgagcc gatcccgcgg acatcttccc cacgggctgg acgcgactgg
     5101 ccgagaaccg gttctcggtc tccgcccgct ggcctgctgc gcatcccttc ttctctccgg
     5161 tggcagggga ccggcacgac cctgtcctgg tggccgagac gatacgccag gccaccatgc
     5221 tcgtctgtca tgccgaactc ggggtacccc ttgacgcgca gttcgtcatg tggggcctca
     5281 attacgcggc cgaccccgag gcgctcgccg tggacggcct ctcctcggac gtcaccgtcg
     5341 acctcgtctg ctccgacgtg atccgccgcg gcggcggcct ccgcagcatg cgcgccaccg
     5401 tcgtgctcac gcgcgacggc cggcacctcg ccaccgggag cgccctgacc cgctgcacgt
     5461 cggccctggc gtaccgccgg atccgcggcg agcgcctggc cgcgctcggc agaccggtcc
     5521 cgctcatacc gggcgtggcc ccgcagctgg tcggccggga gaacctcaag gacgtcgtcc
     5581 tgggcgtggg cgccaggccc ggccagtggc agctgcggat caacaccgga cacaccaccc
     5641 tcttccgccg cccgaacgac cacgtaccgg gcatggtgct cctcgaagcg gcccgccagg
     5701 cggcgacgct gacgaccggg agccgcgcct tcctgcccgc cgccatggag tcctccttct
     5761 cgcggtacgc cgagctcgac agcccgtgct ggatagaggc ccaggccgtg cccggcgccg
     5821 acccctcgac gaccaccgtc ctggtcgccg gccggcagga cggccacgag gtgttccgct
     5881 ccgtgctcac ctccccgtca cgcgacctcg cggtcgtcgg aggcggtctc agcagccgac
     5941 tggccggttg agcggggcag aaggcatggg gcctcgcgtt ctgatcaccg gcacgacggg
     6001 tttcgtcggc agccgggtcg ccgcgctggc cgcgacccgt ccggagcccg gccacctccg
     6061 gctgctcacc cggcgcctgc ttccgcccgc gacgacgccc gggacgacgc ccgcggcgac
     6121 gctcgcgacg gagccggccc cggtgaccga gaccgtcacc ggcgacctcc gcgacgccga
     6181 ctccctgcgt cgggcctgcg agggcgtcga cgtgctgatc cactgcgcct cggcgatcgg
     6241 cggggacgag gagctggccc gcagcgtcaa cgacgagggg acccgggccc tcgtcgaggc
     6301 ggccgtacgc gccggcgtga gccggatcgt ctccctgagc accgcctccg tccacggccg
     6361 cggccccttc cgcgccgccg cccccggcac cctgccactg gctcccggct cggcgaccag
     6421 ccgtacgcgg gcggcgggcg agcggcacgt catggaggcg ggcggggccg tactgcgacc
     6481 ccacctcgtg tacggcgcgg gcgaccggca gctgattccc ggcctgatcc ggctgctcga
     6541 actgctgccg ggcccgctcg acgccggcgc ttcgctgcac tccctgatcg acgtggacag
     6601 cctggcgggc gccctgctcg gcgcggcgtt ctcgccgcgg acggaggcgg gcgcgtacta
     6661 cgtcaaccac cccgagccgg tgccggtggc ggagctgctc gcgccctgcg aggagctcct
     6721 ggtcgggcag gcggggcagg cgggccggtc ccgggcggcg gcggtggacc tcgcggaggc
     6781 ctacgagctg ctcgccggcc accccttcgg ccggcaccac ctggccatgc tcgccaccga
     6841 ccactggttc gccgacgacc gtccgtggga ggagctcggc ggtgacccgg gaccgggctt
     6901 caccgccggg ttcgcggccc acacgtggtg gtaccggaat cttctcgacc cttcctgaac
     6961 cgcgagctcg tcaccgagcc cgtgaccgga aacccgtcag cgcaagcccg taccgaagga
     7021 aggcaccacc gacatgtccc cgctgaccgg caggaccgcg atcgtcacgg gcgcgagccg
     7081 cggaatcgga agaggcatcg cggagcgtct ggcgagggac ggggccttcg tcgccgtgca
     7141 ctacggcagc aacggcgagg ccgcgcgcga gacggtggag cgcatcgagg agagcggcgg
     7201 ccgggccttc gccttccgag cggagctcga agcgcccgac gccgtcgaca cgttctacgc
     7261 ggcgctggac gccggtctcg cggagcacgg tgcggaccac gggttcgaca tcctcgtgaa
     7321 caacgcgggc gccagcggct ccggccgcat ccacgaactg accaccgagg tcttcgaccg
     7381 gctgttcgcg atcaacgtga aggccccgct gttcctgatc cagaggggcc tcggccggct
     7441 gcgcgacggc ggccggatcg tcaacgtctc ctcggcggcg acgaggatcg ccttcccgga
     7501 ctccgtcacc tacgcgatga cgaagggcgc cgtcgacacg atgacgctcg ccctcgccaa
     7561 ggagctggga ccccgcggga tcacggtcaa cgccgtggcc cccggcttcg tcgcgacgga
     7621 catgaacgcg cgacgcaggg cgacgccgga ggcgagcgcc gccctcgccg cctactcggt
     7681 cttcaaccgg ctcgggacac cggccgacat cgcggacatc gtcgggttcc tcgtctccga
     7741 cgacgcccgc tggatcaccg gccagtacgt ggacgccacg ggcggaagcg cgctctgagc
     7801 ctccgggcct ctgagcgtcc gagctgccga gcctcggtca gccgaccggg gcgagggagt
     7861 ggatgatcac ggccggggtg ccctccggtt ccaggcccgc gtgggcctcc ggggccgtca
     7921 gggccgggag cagcgtgcgc cataagccgg tgacggcgtg gggcgagagc cactcgccgc
     7981 tgtcctggga cagggtcacc aggccgatgg tggcggcgac gatcgtgcgg gcgaggtcct
     8041 gctgacgcac ggcgccgccg ccgaggaggc cctcgtcggc cgcctcggcg agccgctgct
     8101 gtacacagct ctgccattcc tggcgcagat tgagctccgt acggcagtgg ttcgcgcagc
     8161 tgagtcggaa gccggcccgt acgacgatgt cctcgcggaa cagccgggcg agcgcgtgcg
     8221 tggtgtccac gaggttctgc agggcgttgg accggtggcc gtacgcgatc cgggcggtcc
     8281 gccgcagcgt cgtacaggcc gcgtcctcga ccgcctcggc gatggcggcc ttgttctcga
     8341 agtggaagtg gagcgccccg gggctgacgc cggcgcccac gctgatcgcg gacagcgtgg
     8401 ccagggcgta gccgtgctga tggaactccc cggcagccga ccggatcagc gcgtcgcggg
     8461 tccgtgtgcc ccgctcttgt ttggtcacca acggctcccg tagcacccat gcgtcgctgc
     8521 ggcacggacc tgcatcacgt cacgccgaac cacccgacga cctcaaaccg actgattggt
     8581 attctacgag gttccgtcgt ggcccagggg cgtatctcgg ttgtcggatt tgcctacccc
     8641 gggagggtgt cggcgtaagt cccccagaag gcgttcggcg cgtacgggga gggggtcggg
     8701 cggtggggag gtgcctgcga acagaccggg aggaaggttt gtcgacccgt cagcggcagg
     8761 ggccggtgcg gggcttcaca gctcgggaag tcccagcggg acccggcctt ccgcccggcc
     8821 ctgctcgtcc aggagccagc ccatgcgctt gcgggagaac aacgacaccg tccggtcccg
     8881 cacttcgagc gccgggaagc gctccgcgag cagcgcctcg aaggggtcga cggcgcccag
     8941 tccgtgcagc cagaccagga cgagcaggtt gtacggaccg ctcaccgaca cgcacatccg
     9001 cacctgttcg agccgggcca gcgcgttccc cgtctgttcg aggagggcgt gcggcacgga
     9061 cgtccggtag accaccatcg tggacaggcc cgccagcggg tgcgccagat cgcagcgcag
     9121 cgagatgtcc ccgtcgcgga tcatccgctg gagccggcgc cgcgcggtgt gctcgctcat
     9181 gcccgtccgc gcgccgagtt ccgcgtaccc gagccgtccg tcaccgccga gcgcgccgat
     9241 gagcgcctgg tcctgcggcc ccggccgctc gtggaggtgc gtgctgtacg agcgggggcg
     9301 cgggcccggc ggcccgccga ggccggcccg ctccgccggg ttcatcgccc gcatccgcca
     9361 gtcgcgcccc tctccgtaca gcgtgatgcc cagcctcgta cgggtcgagc gcaccccgcg
     9421 caggccgccg atcccgccgt ggaccgcgcg tccgagcgag ggcaggtcgg gggcggcgac
     9481 ggagaggaag aggtcgaagt ccccggcggt ctcgtcgacg ccgaacaccc acggcagcgc
     9541 cgtcaccgcg gcactgaccc ggtcgaaggc ccggggccgg caccgcacct cgacgtaggc
     9601 gaccgtcgcc gtcttcgccg cgtcgtacgc ggtgacccag gccagcccgc cggcccggag
     9661 ccgttcgaag cggcgggccg ccgtcgtcgc gtccacgccg agcgcccgtc cgatccgggt
     9721 ccacggcgcg cggggggcgg cctggagcgc gtcgaccagc gcgagatcca gctcggtgaa
     9781 ccccgtggcg gaatccgccg tgcgggaatc cggcgcgacc ggagcattat cgagggtttc
     9841 cggcagttcc ccggggtgca cgctcatgga ccggatcgta ggggcacttc cggccgacga
     9901 ccagattcgg ccaccgctga gaggagtgcc gtgcctgctc cgacccttcc cgcaccttcg
     9961 gcggcgccgc ccgcgcaccg gagaaccgtg cggctcacgg tcgtcctgct cttcgcggcc
    10021 tggctggtcg actacgccga ccggctcgtg atcaacctcg tactgccgtc catcggcgtg
    10081 gagttcgacc tcgaccgcac ccagcagggg ttcgtcgtct ccgccttctt cctcgcctac
    10141 gccctctgcc agatccccgg cggcatgctc gccgaccggt tcggcggccg acgggtgacc
    10201 ctctgggccc tgctggcctg gtcggtcttc accgccctca ccggcttcgc ctggtccttc
    10261 gccgtgctgc tcgccctgcg cttcgccttc ggcgtggccg agggcgtctt cccgccggcc
    10321 gccatgaagg tcctggtcga gcgcacccgg ccggaggagc gcatgggcgc caacggcacg
    10381 gtgatgagct cgaacgcgat cgccgccgtc atcacaccgc tcgccgtcgc cccgctggtc
    10441 gccgtcttcg gctggcgctc ggccttctgg tccaccgccg ccctcgggct cctcgccctc
    10501 gtggccgtac gccgctggct cccggccccg ctgccgcgag gtgcggacgg cccggcgccc
    10561 ggggacgacg gcgccccggt cgcccgggag gccgcggcgg cctccccacc gctccgcgag
    10621 gtgctgcgca agggcgtgct gtggcggttc tccctcatga tgttcggcta caacacgatc
    10681 atctggggcc tcaacacctg ggtcccgtcg tacctcagcg aggagcacgg ggtctccctc
    10741 accgcggccg gagccctcgt cgccgtcccg gcgctcgggg ccgccaccgc caccgtcctc
    10801 ggcggacggc tctccgaccg gctcggcggc caccaccgca aggtcatcgt ccccggcatg
    10861 ggcgtctccg ccgccgccct cctcctcatg gcgaacacac cgtccctcac cggcttcgtc
    10921 gtcttcggca ccctcgccgt cttcgccgcg t
//
