LOCUS       NZ_CP059991            25263 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptomyces gardneri strain ATCC 15439 chromosome, complete genome.
ACCESSION   NZ_CP059991
VERSION     NZ_CP059991.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces gardneri
  ORGANISM  Streptomyces gardneri
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9054805)
  AUTHORS   Kim,W., Hwang,S. and Lee,N.
  TITLE     Genome-scale analysis on the transcription unit architecture of
            Streptomyces venezuelae ATCC 15439
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9054805)
  AUTHORS   Kim,W., Hwang,S. and Lee,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Biological Sciences, KAIST, 291 Daehak-ro,
            Yuseong-gu, Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 6.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: CP013129
            Genome Coverage                   :: 187.8x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015710995.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 17:12:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,199
            CDSs (total)                      :: 8,101
            Genes (coding)                    :: 7,918
            CDSs (with protein)               :: 7,918
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 184
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 184
            Pseudo Genes (frameshifted)       :: 70 of 184
            Pseudo Genes (incomplete)         :: 147 of 184
            Pseudo Genes (internal stop)      :: 16 of 184
            Pseudo Genes (multiple problems)  :: 48 of 184
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:23:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2865080
            Orig. end                         :: 2890343
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059991.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25263
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25263
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25263
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15263](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15263
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            187..507
                     /db_xref="GeneID:95689476"
                     /locus_tag="H4W23_RS12930"
                     /old_locus_tag="H4W23_12925"
     CDS             187..507
                     /codon_start=1
                     /db_xref="GeneID:95689476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447303.1"
                     /locus_tag="H4W23_RS12930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12925"
                     /product="DUF6238 family protein"
                     /protein_id="WP_230883014.1"
                     /transl_table=11
                     /translation="MTVTTDHTALPADERAVRQDLDQLHAEALDLARRMKELALVLDHG
                     DYSAAGGRVRTAVAHIWRAAEDLHSAFHTAPPRCAGPDASMSRLCGRRMRYLAARVARR
                     AE"
     gene            507..770
                     /db_xref="GeneID:95689477"
                     /locus_tag="H4W23_RS12935"
                     /old_locus_tag="H4W23_12930"
     CDS             507..770
                     /codon_start=1
                     /db_xref="GeneID:95689477"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="H4W23_RS12935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="H4W23_12930"
                     /product="hypothetical protein"
                     /protein_id="WP_055643653.1"
                     /transl_table=11
                     /translation="MDIMPGGISLVLYAVTAVCAVALVTLWFLLNRGRRNAGFASKGQL
                     KRQMSAKAVLKATEIRPSLTSDDRHPSRATRVSFAKDRPAGH"
     gene            814..2262
                     /db_xref="GeneID:95689478"
                     /locus_tag="H4W23_RS12940"
                     /old_locus_tag="H4W23_12935"
     CDS             814..2262
                     /codon_start=1
                     /db_xref="GeneID:95689478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447312.1"
                     /locus_tag="H4W23_RS12940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12935"
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="WP_055643652.1"
                     /transl_table=11
                     /translation="MHHPLDPHDFGYSLGTSQRPKGVELWSRADKACRVIGPMGSGKTL
                     RFFAPLVRNWAGPVLATSTKPDLVELTLDARQRDGRPVAVFDPQNIAPSLPRFRWTPIN
                     GAADTEVAIMRGKAFVAGSRTPNGAAQSSEGSAFYKGQASKIIAAFFHAAALDGASLDW
                     VLRWARKLTDPAPLGILNAHPGAGPGWADMLRTATTGDSRTVGNTASTLDAALEPFMHQ
                     SVINALQGDGEDPTDFGAFLDAGGTLYLLGKDSEVNSVAPLTTAIAEDLLDFAEAHALA
                     SPAGRLDPALLAALDEAPNIAPIPSLRQRVADGRGRGITVVYGLQAWASARARFGEDTA
                     KELAAFTNNVIVLPGDKDPDFLKDMSDLCGQVERERTTKTTSGGDRGGHSTATHMALEP
                     VLRGDEIRGLPEGHALVLADNLPPIVTRLDGMWTWDSWAEIEGHVRDLRAANEAERTLR
                     ATEKKNRAKAHAVAWAGREGAAAA"
     gene            2259..2765
                     /db_xref="GeneID:95689479"
                     /locus_tag="H4W23_RS12945"
                     /old_locus_tag="H4W23_12940"
     CDS             2259..2765
                     /codon_start=1
                     /db_xref="GeneID:95689479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447313.1"
                     /locus_tag="H4W23_RS12945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12940"
                     /product="hypothetical protein"
                     /protein_id="WP_055643651.1"
                     /transl_table=11
                     /translation="MIETLTHFEPFPEPPALILEYIAERSTEESVAADGPVPWDIGALS
                     AELIKPMPAWLDSVCRWLNRTYAWQPQDVIPPCWAKHEGLAYEIAALAFARGDAYAEAG
                     SSVIWHEQYDRFLTRMNKSLGKAGDECRVGRHDDRPARFQLAAWPTAKGEETGSAGRVE
                     EMVAG"
     gene            complement(3324..3956)
                     /db_xref="GeneID:95689480"
                     /locus_tag="H4W23_RS12950"
                     /old_locus_tag="H4W23_12945"
     CDS             complement(3324..3956)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689480"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571578.1"
                     /locus_tag="H4W23_RS12950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12945"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_055643649.1"
                     /sec_met_domain="HAD_2 (E-value: 1.4e-07, bitscore: 30.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPYRGLILDFGGVLTTRMRLNGQAFERTEGLTPGAYFAALNEH
                     PDGVAIYAALEVGEATQEDWNRVIGGILGIDSTDLMRRALANLHPEPQIVAAAKRARAA
                     GIKVAMLSNSFGIEPYNPYEDKGMWTDFFDAVILSELEGVRKPSPLIYQRALDALDLTG
                     PECVFVDDHAENLPPAETLGIRTVHHTTDPTGTAAILDSLLLDPAPA"
     gene            4131..5351
                     /db_xref="GeneID:95689481"
                     /locus_tag="H4W23_RS12955"
                     /old_locus_tag="H4W23_12950"
     CDS             4131..5351
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571579.1"
                     /locus_tag="H4W23_RS12955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12950"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_055643648.1"
                     /transl_table=11
                     /translation="MVYDGELFSIGQRIKWWRERRGLSQRMLGDLIGRSENWVYKIEND
                     RMPLDRLPILIALSKQLRCSLEDLTGGYVSGIVTAGTEHEHVPLIRQALSLPASLLPQR
                     IGSVTSDDFESSVTDAWKVYETQADDRYRDVGERLPALLRQGHAALRDASPEQEGTVLR
                     QLISLYGLHQIWLRRVGEPTLARIAADRGLSLADNAGDPALLAAAAWNLACVLTSAGDV
                     EDSYELARQTIAQCRPHDDSNAEHWSAYGALHLQGAVAAVRATKGPRAWDLYNGAQQAV
                     DRVGADLNHWHTCFGPTNFAMHEVHLKAEEGDTSEALRAADHVLVNEEVPLERRTRYLI
                     EVMNLNRIQRDDYATVHILGKLLKQSPEEIVFSPLVREAVADLLKREKPMWRDDLREVA
                     KHIGLAA"
     misc_feature    5383..5392
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.26"
                     /tool="antismash"
     gene            5917..6333
                     /db_xref="GeneID:95689482"
                     /locus_tag="H4W23_RS12960"
                     /old_locus_tag="H4W23_12955"
     CDS             5917..6333
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010473467.1"
                     /locus_tag="H4W23_RS12960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12955"
                     /product="ATP-binding protein"
                     /protein_id="WP_262388013.1"
                     /transl_table=11
                     /translation="MEERFSITKHSPGERPPPVDESRVRAMRLVTRERLTSRGLTCVAD
                     DATLVVSELITNAIVHSGGRQIRLTLDVRDGVLRIRVHDGVPGPRPTAQCPEDDAENGR
                     GLVLVQEIARSRQGAWGVSDDGATTWCELSLVAC"
     gene            6333..6848
                     /db_xref="GeneID:95689483"
                     /locus_tag="H4W23_RS12965"
                     /old_locus_tag="H4W23_12960"
     CDS             6333..6848
                     /codon_start=1
                     /db_xref="GeneID:95689483"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="H4W23_RS12965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="H4W23_12960"
                     /product="hypothetical protein"
                     /protein_id="WP_148901584.1"
                     /transl_table=11
                     /translation="MTNTALRDETTSPETMPVRVKDPTVPTNPWTPPHGEEEARRYLSA
                     VREWASVDWNEVYDDLDTILHGEEEISHHAAGPSGGAPLPNYNNDALTQRFLMALKLLV
                     ARALRDKADEKHPDIAALIGQACTLRAEVVAGDAGQTIGLVRKLARLTLDLAELLEEAG
                     IVRGLVEC"
     misc_feature    6348..6350
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6582..6584
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6842..7306
                     /db_xref="GeneID:95694963"
                     /locus_tag="H4W23_RS40895"
     CDS             6842..7306
                     /codon_start=1
                     /db_xref="GeneID:95694963"
                     /inference="COORDINATES: protein motif:HMM:NF040050.4"
                     /locus_tag="H4W23_RS40895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6302 family protein"
                     /protein_id="WP_079037616.1"
                     /transl_table=11
                     /translation="MLTTTKASTRSFGPSLCPAEEAYDFEHFRNRLARPEVLAHAVAVR
                     VFRAPLLAVPVGGPRRGGYMSFDLLSLAIGARDLLTNRPGFPDLRVRWSPYRDTCHTVE
                     WGDPAPGWWEDDAVFGRFYGYSESAITSFVGARPQTPSSATSTPCSPTAS"
     gene            7360..7563
                     /db_xref="GeneID:95689484"
                     /locus_tag="H4W23_RS12970"
                     /old_locus_tag="H4W23_12965"
     CDS             7360..7563
                     /codon_start=1
                     /db_xref="GeneID:95689484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016910434.1"
                     /locus_tag="H4W23_RS12970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12965"
                     /product="DUF5999 family protein"
                     /protein_id="WP_055643646.1"
                     /transl_table=11
                     /translation="MCQHTPPCPTAEASDREAARPTVAHPEQGWSLLCNGVLLFEDTGE
                     LLPDGQIVAPHRPVALAAGSTA"
     gene            7560..8207
                     /db_xref="GeneID:95689485"
                     /locus_tag="H4W23_RS12975"
                     /old_locus_tag="H4W23_12970"
     CDS             7560..8207
                     /codon_start=1
                     /db_xref="GeneID:95689485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143560.1"
                     /locus_tag="H4W23_RS12975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12970"
                     /product="hypothetical protein"
                     /protein_id="WP_063785778.1"
                     /transl_table=11
                     /translation="MTTAPQIVVPYITAREGEEADSFLNLRMGRGPDGRPRLRYVDEAP
                     PDRDLKGVLWARYSMSLDTFGQPCGTPRWRMVHPHRQRVTMALLRCQVCTVQLKRTDGV
                     LFLETAGEEGYDGPVKTAQPPVCLEHARMAAGRCPRLRARGHVALLATRFPLYGVIGHA
                     YQWSANGLQALSDMDSPIPYRHPQIGMFLASQLVRELREYKVVNLDDLVPAA"
     gene            8411..9649
                     /db_xref="GeneID:95689486"
                     /gene="fxlM"
                     /locus_tag="H4W23_RS12980"
                     /old_locus_tag="H4W23_12975"
     CDS             8411..9649
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689486"
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490583.1"
                     /locus_tag="H4W23_RS12980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12975"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_055643645.1"
                     /sec_met_domain="PCMT (E-value: 7.1e-36, bitscore: 122.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTTVEPDEATRLRNKVVDELCADGNISSPEIEAVMRKVPRHEF
                     TPADTPLDKAYDTYAAVITKTDEHGVQLSSVSAPQIQAMMLEQAQVKPGMRVLEIGSGG
                     LNAAYLAELVGEDGEVVTVDIDPVVTDLARQLLNEHGYGRVHVVTADAAEPIPDLGEVD
                     VVMVTAGAWDVSPAWTAQLKQGGRLVVPLRMRGLTRSVAFIQVKGEHGPYLESESARIC
                     GFVPMQGSTAHREELLLVNGTPEIGLKFDDGLPADPHRLDNAVTSPRHELWTGVTVRIQ
                     ELIDTLQMAMAISLPGFCTMAVDENSDSGMVAPVNKRFALAAVEDDTFAYLVTRRTEDN
                     KHLEYGVHALGPHAEQFADKIADVLRDWEANRRGGPSPVIRVYPDGTPDDQIPADRVID
                     KVHSRVSLSWPSA"
     gene            9701..9904
                     /db_xref="GeneID:95689487"
                     /gene="fxlA"
                     /locus_tag="H4W23_RS12985"
                     /old_locus_tag="H4W23_12980"
     CDS             9701..9904
                     /codon_start=1
                     /db_xref="GeneID:95689487"
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="H4W23_RS12985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12980"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_030881377.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.5e-14, bitscore:
                     51.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATLAPPPVAPAPSADLDDDFAPLDVKVVIAEHSYGHLMCSTG
                     DGCGTTCATGASACGSFTEDPA"
     gene            10001..13066
                     /db_xref="GeneID:95689488"
                     /locus_tag="H4W23_RS12990"
                     /old_locus_tag="H4W23_12985"
     CDS             10001..13066
                     /codon_start=1
                     /db_xref="GeneID:95689488"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746441.1"
                     /locus_tag="H4W23_RS12990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12985"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_055643644.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.3e-200,
                     bitscore: 665.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.1e-15,
                     bitscore: 57.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-12, bitscore:
                     47.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASRAAAGYQWQGVAMLRATTSPGPADIPRTLDLDNVAVTRGWLN
                     RIWQREDFRSALELATPVLSDAIEAVVRGRQTEPRHVRRTALSTVSYLLRWQHRPTPLG
                     LFAGTAPVSVGPRASARWRDKHRAMIRPDAEWVTDMVLRLQRTPALLKRLPLVANNAAR
                     ARGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAAMDAARTPILYSGLHSHLRDRFPQ
                     ATPEKIDALLTSLVEQQFLITSLWAPMTTVDGFQHLCRELDRLQADDVPEVRDLVHALY
                     ALRDDVSAHQPTLSDTSVSAVAARMRALTTVTPTPLLIDTALDCETQLPQPVIAEVQAA
                     VSALYRTTPQPYGYQHWRDYHRRFRARYGVGALVPVMDLVADSGLGLPAGYVGSERGAA
                     LKVRTDRDELLLALMQQVLLDGRDELRLTDDMVDALEKAAGEDERLFVPRVEAAFEVHS
                     PSTRALSSGTFDVLLTAVPRPGSSMAGRFAHVLPPEHQDALAATYHGAPDALTAQLVFP
                     PRRHRNENVTRTPRLLPHVIELSGHQETDETTIPLADIAVTADPRSFHLVQLSTGRRID
                     VRVLHALEGGTQTPPLARFLAEVANGRYAAYKPFDFGAGARLPFLPRVRYRRTILTQAR
                     WLLRADDLPGRKASTEEWEDAFTAWRDRLRVPMQVAIIEYDQRLPLDLSHPVHRRALRA
                     HLDNARRLELREVPDADAHGWIGRAHEIWLSLGRLQPDTADVPRPRPAAPPAPGRHLPG
                     AGDVLLAQLHAHPRRYDEILSRHLPSLLAAFGDTPPLWWFTRHREMARPDADQHLDLTL
                     HLPPDAYGAAAQHVRTWADSLHGTGLAAGLVLAPYQPQTGRFGSEAAMDAAHQVFAADS
                     AAALAQIQLTERTDAVAPQALAAASALHLVTPLAPDTAAAEEWLVRNLPQGKGRLNRAL
                     RTQVLELAAPNGASALAALPGGSAVAEAWRARVVAVDTYRNALTGQRDPLGVARSLLHQ
                     HHVRALGVDPRAEETTIRLVRTAALQHRMAAR"
     misc_feature    10460..10462
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10469..10744
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_H4W23_RS12990_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.80E-18"
                     /identifier="RREFam001.1"
                     /label="H4W23_RS12990"
                     /locus_tag="H4W23_RS12990"
                     /protein_end="248"
                     /protein_start="156"
                     /score="57.0"
                     /tool="antismash"
                     /translation="VANNAARARGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAAMD
                     AARTPILYSGLHSHLRDRFPQATPEKIDALLTSLVEQQFLITSLWAP"
     gene            13063..14292
                     /db_xref="GeneID:95689489"
                     /locus_tag="H4W23_RS12995"
                     /old_locus_tag="H4W23_12990"
     CDS             13063..14292
                     /codon_start=1
                     /db_xref="GeneID:95689489"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490581.1"
                     /locus_tag="H4W23_RS12995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12990"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_055643643.1"
                     /sec_met_domain="LANC_like (E-value: 4e-36, bitscore:
                     123.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPAVTTAAILEQYTARLAQPAPPSPDEPWAVQSLADGAAGISL
                     LHIEMASRHGGSWRPAHRWITAAAAGHISAADTAGLFLGAPALGFVLTTVPPSFQHLYE
                     PARRTLHQHITDLTHRRVDAALTRIRKGDLPTFAEYDLFYGLTGIGAYLLRTDPEGLPL
                     ERVLKYLVALTRPLVPDGRGLPGWWVRHDPARGESLHYPGGHGNFGAAHGITGPLLLLA
                     QAVRRGITVSGHREAIWSICEHLDAWCQLSPSGPWWPEHISRRDLNLGRPHHDAPTRPS
                     WCYGTTGIARAGQLAGLALRAPDVQAFYEDALYRALTDPEQLAHVTDSGLCHGWAGIYQ
                     TATRAAADARDPRLQTLPKRLGNILAANAQPCLPEPGLINGDAGTALALTTYASQQAPI
                     SGWDACLLIN"
     gene            14295..15263
                     /db_xref="GeneID:95689490"
                     /locus_tag="H4W23_RS13000"
                     /old_locus_tag="H4W23_12995"
     CDS             14295..15263
                     /codon_start=1
                     /db_xref="GeneID:95689490"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490580.1"
                     /locus_tag="H4W23_RS13000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_12995"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_316248008.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.5e-35, bitscore:
                     119.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPSPVQRAVSAALTGLPIPEVAAQYGMEPTILSDAVAVYDQAG
                     REALARHAAATDWWHVYLHFTDWTAADTTFTTHVLPVLGEAEATGLMSGWWYTRKHPCW
                     RLRLRLQPEAGTKLTLGDGFDRLVSDGHLHRWWPGIYEPETAAFGGAVSMMAAHALFVT
                     DSREAQQLRQRGDLAVGPRELSVLLCTIMMRAAGLEWYEQGDVWHRVITEEHRSAVSDV
                     PADRLDARAQEIRPLLFADSDVLLRPGGLLEPVAEWAAAFRSTGQELRRAVQDGTLDRG
                     LRQVLSYHVIFHWNRLGLSMRGQSVLAWAARAAILHRESGT"
     misc_feature    15295..15309
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.02"
                     /tool="antismash"
     misc_feature    15388..15403
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.48"
                     /tool="antismash"
     gene            15896..16429
                     /db_xref="GeneID:95689491"
                     /locus_tag="H4W23_RS13005"
                     /old_locus_tag="H4W23_13000"
     CDS             15896..16429
                     /codon_start=1
                     /db_xref="GeneID:95689491"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="H4W23_RS13005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="H4W23_13000"
                     /product="hypothetical protein"
                     /protein_id="WP_057950454.1"
                     /transl_table=11
                     /translation="MGLDEDQAQRLVQGELDMGVSHCKDPWDSPFSPRGELCAVAPLRC
                     LECRNAWVLPSQLPQLMLFAEHLERVRRRLDPVTFTRQWGQSYVNLQAALDERTDQEKA
                     LAQQHIDAGTGPSGPAAVRARGVRRVIIPNTGGHTHSLFRQDTDQPGRLPIAGRKRPVR
                     AAYCTYAGPWTRRR"
     gene            complement(16339..16944)
                     /db_xref="GeneID:95689492"
                     /locus_tag="H4W23_RS13010"
                     /old_locus_tag="H4W23_13005"
     CDS             complement(16339..16944)
                     /EC_number="2.1.1.100"
                     /EC_number="2.1.1.334"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689492"
                     /inference="COORDINATES: protein motif:HMM:NF016107.5"
                     /locus_tag="H4W23_RS13010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_13005"
                     /product="isoprenylcysteine carboxylmethyltransferase
                     family protein"
                     /protein_id="WP_055643641.1"
                     /transl_table=11
                     /translation="MAVLALVLFAAFLLLAGVARILIQYHRTGDTGVRRARAAGPAQQW
                     ARAALIAGSLLTGVAAPVAELLGLPAAPVLDQPGLRASGAVLAALGIAAVVGAQNAMGA
                     SWRDDVDPAERTALITHGPFSLVRNPIYTAALAWAAGLALLVPNLIALPGPLLLLVGLE
                     IQVRYVEEPYLRRVHGPAYVQYAARTGRFLPAIGRRPG"
     gene            complement(16984..17490)
                     /db_xref="GeneID:95689493"
                     /locus_tag="H4W23_RS13015"
                     /old_locus_tag="H4W23_13010"
     CDS             complement(16984..17490)
                     /EC_number="3.4.23.36"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491734.1"
                     /locus_tag="H4W23_RS13015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_13010"
                     /product="signal peptidase II"
                     /protein_id="WP_055643640.1"
                     /transl_table=11
                     /translation="MPEHTTRVSSAARRRTALAAGAAALAAADLALKTWAQSALADAPI
                     GPDFAQLRLAFNPGVAFSMGDTLPSWVVVAFTALITAGVGVFAWRTAPQSKAAAAALAV
                     ILAGAAANLVDRAGDGVVTDYLHTGWWPTFNLADVFIVCGGLAVVALSWRRPAPKPGRA
                     SSPAA"
     gene            complement(17494..19458)
                     /db_xref="GeneID:95689494"
                     /locus_tag="H4W23_RS13020"
                     /old_locus_tag="H4W23_13015"
     CDS             complement(17494..19458)
                     /codon_start=1
                     /db_xref="GeneID:95689494"
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491733.1"
                     /locus_tag="H4W23_RS13020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_13015"
                     /product="cation-translocating P-type ATPase"
                     /protein_id="WP_055643639.1"
                     /transl_table=11
                     /translation="MGDACGCSGDEPRTGDEAEEAAPEKIWQVSELQWAAVGGVFLLAG
                     FLTGLAGGSETVQLVLNAIALAAGAWTFVPGTLRRLAKGKIGVGTLMTIAAVGAVILGQ
                     VEEAAMLAFLYSISEGLEEYSLARTRRGLRALLDLVPSEATVLRDGAQVTVDPATLKMG
                     DLLLVKPGERVATDGTIRSGRSALDVSALTGESVPVEAGVGEAVYAGSINGTGVLEVEV
                     TATAADNSLARIVKIVEAEQSRKGAAQRLADKIAKPLVPGIMVLAAIIAVTGSILGDPQ
                     TWIERALVVLVAASPCALAISVPVTVVASIGAASRLGVLVKGGAALEALGRIRAVALDK
                     TGTLTRNEPTVIRTVSVDGRSDKRVLEIAAALESRSEHPLARAILAAAPQHPHADAVEA
                     VTGAGLTGTVDGRPARLGRPGWIEPGTLADDITALQNAGATAVLVEYNGHVIGAIGVRD
                     ELRPEAAEVVSRLHASGYTVAMLTGDNQRTAAALAAQAGITEVHADLRPEDKATLIRSM
                     REKRPTAMVGDGINDAPALASADTGIAMGAMGTDVAIETADVALMGEDLRHLPQALDHA
                     RRSRAIMLQNVGMSLGLITLLIPLAAFGVMSLAAVVAVHELFEVVVIGNGVRAGRTRPL
                     PPAPVAKAADQPVPAAAGV"
     gene            complement(19451..19852)
                     /db_xref="GeneID:95689495"
                     /locus_tag="H4W23_RS13025"
                     /old_locus_tag="H4W23_13020"
     CDS             complement(19451..19852)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689495"
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491732.1"
                     /locus_tag="H4W23_RS13025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_13020"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_055643638.1"
                     /transl_table=11
                     /translation="MTMNNMGVAPAATTTSCGAPSAAVALFRSLGEPARLAILMRLAEG
                     EARVVDLVKALGLAQSTVSAHLACLRECGLIDSRAEGRSSFYFLARPELLDLLASAEDL
                     LAATGEAVDLCPTYGRTPAAAQRKENNHG"
     misc_feature    19856..19871
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.13"
                     /tool="antismash"
     gene            20187..20873
                     /db_xref="GeneID:95689496"
                     /locus_tag="H4W23_RS13030"
                     /old_locus_tag="H4W23_13025"
     CDS             20187..20873
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689496"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991734.1"
                     /locus_tag="H4W23_RS13030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_13025"
                     /product="response regulator transcription factor"
                     /protein_id="WP_055646312.1"
                     /transl_table=11
                     /translation="MHVLIVEDDQRIADALGEAMQRFGHDVTRVATGREALTVAESTEF
                     VLLDLGLPDLDGQEVCRRLRERSWVPIIAVTARAEEVDRILLLQAGADDYLIKPYSMRE
                     LLARMDAVARRVTGPAAAAGGESREDRWAAGPLVLDLRTRQVEVHGVPVGLTRREFDLL
                     AALAADAGAVRAREDLINEVWDVNWHGSTRTLDVHVGSLRNKLGVREWIESVRGVGFRL
                     AVPDAA"
     misc_feature    20197..20206
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            20938..22356
                     /db_xref="GeneID:95689497"
                     /locus_tag="H4W23_RS13035"
                     /old_locus_tag="H4W23_13030"
     CDS             20938..22356
                     /codon_start=1
                     /db_xref="GeneID:95689497"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="H4W23_RS13035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_13030"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_148902888.1"
                     /transl_table=11
                     /translation="MRGHLVAALVVLPTVVLVVLGLPLAAERDDRAVRQLTQIRTQQAR
                     EMKDLAAGVVRSGDSDRARRHIADFQDRTGGRIQLYDTTGRALLGALCILSPEELRDEE
                     PVQAALRGDFRDSAEQRVSWQAGELVVAVPVVDGGVLVGVVVICSFLDDLQIDVLTAWV
                     IIAVIALLALAVAAFLAEPLARWILKPIRYLERAALDFAAGDHDARVPVDQGPPELRVL
                     AETFNHLAQQVQHQVQVQQSFVADASHQLRSPLVALSLRLENLEPYVDKDGAARLAQAL
                     AEAERMSRILNALLLLARSETEDQPAHPVDVLAVLEERVASWRTVAAPRAVEIDIVEGR
                     ELLGAAIPGTLDQILDVFLDNAVRVSPRGSSIRLRVVADEGVVAVQCQDQGPGMSAADR
                     SRACDRFWRGPDAEPGEGSGLGLAIAASLARANGGEVLLERAPAGGLHAEVRLPNWQPA
                     LTCSGPAALESRRR"
     misc_feature    20971..20973
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21199..21201
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21820..21822
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(22434..22447)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.28"
                     /tool="antismash"
     gene            22668..24857
                     /db_xref="GeneID:95689498"
                     /locus_tag="H4W23_RS13040"
                     /old_locus_tag="H4W23_13035"
     CDS             22668..24857
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:95689498"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538107.1"
                     /locus_tag="H4W23_RS13040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H4W23_13035"
                     /product="MMPL family transporter"
                     /protein_id="WP_230883015.1"
                     /transl_table=11
                     /translation="MGTWLARRRVLVLLLTLAALVVAVPFGSDVESRLSEGGITAPGSE
                     AARADELLNTRFEGGSPHLVFIAKAASSVDAADAAKEGQALTDRLAKEPGVVQAASYWS
                     LGNSEALKAKDGKSALIMVRLAGDEDQVRKHAKRVMPTVIGEQGPFKLTATGATAVRME
                     IEKQSEEDLVKAEMLSAPLVLIILLLVFGSVVAASTPLAVGVLAVIGSFVVLRLLDMVV
                     QVSVFSVNITTALGLGLAIDYSLFIVTRFREELAAGREVHPAIAETMRTAGRTVLFSAL
                     TVALSLSAMLVFPMYHLRSFAYSGIAVVALAALGSVIVLPALLAVLGRRVDAWNVLWWR
                     RKSKNSGARSDREGFWHRLAMAVMRRPLPFALTVTAVLIALGIPFLRVEFADSDDRVLP
                     ASSAAHQGAQVLREQFDSQEGSPIAVVLPDLDPQTDSKDVAAYATALSKLPDVTRVDAA
                     TGSYNAGREVAPPSEISQRFAAKGTGSGTWLSVTSDTEPYSQRGMSLVSTVRAVPSPSE
                     SLVGGQAALLVDSKDTLGDKLPWALGIIAASTLLLLFLFTGSLLIPLKAIVLNLLSLTA
                     TFGAMVWVFQEGHLRWLVGDFTVTGAIDIDTPVLMFCVAFGLSMDYEVFLLSRIKEEYH
                     RTGDNVSAVAWGLERTGRLVTAAAVLVATVLLAFATSGLTPLKLLGVGLALAVIVDATL
                     VRGILVPAFMRLAGRANWWAPRPLARLHKRIGLDD"
     misc_feature    22699..22713
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.76"
                     /tool="antismash"
     misc_feature    24978..24993
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    complement(25242..25251)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 gtggaaggtc ggcgaggtga tctaccccgg cgtccagcac ctcttggtgg aggccgagca
       61 gcacctgtgc ttctcctccg gctcgatgac cgacctgacc agcacctccc cggacgccga
      121 atgagcgggc accgcctcct gtcgaccgcc gaccccttcc acgcagattc ggaacgagcc
      181 ctcgccatga ccgtcaccac cgaccacacc gcgcttcccg ccgacgagcg cgcggtgcgg
      241 caggacctcg accagctgca cgccgaagcg ctcgacctcg cccggcgtat gaaggagctg
      301 gccctcgtcc tggaccacgg cgactactcc gccgctggag gacgcgtacg tacggccgtc
      361 gcccacatct ggcgagccgc cgaggacctg cacagcgcct tccacaccgc gcccccgcgc
      421 tgtgccgggc ccgacgcgtc gatgtcgcgg ctgtgcggcc ggcggatgcg ctacctggcg
      481 gcccgcgtcg cccggagggc cgagtaatgg acatcatgcc cggcggcatc tcccttgtcc
      541 tgtacgccgt gacggccgtg tgcgcggtag ccctggtgac gctctggttc ctgctgaacc
      601 gcggacggcg caacgccgga ttcgcgagca agggacagct caagcgccag atgtcggcca
      661 aagcagtcct gaaggccacc gagatccgcc cctccctcac cagcgacgac cgccacccca
      721 gccgcgcaac cagggtgagt ttcgcgaagg accgccccgc cggtcactga ccctctttcc
      781 tcgtcgcccg cccacctcgc tccggagtac gtcatgcacc accccctcga tcctcacgat
      841 ttcggctact cgctgggcac gtcgcagcgc ccgaagggcg tcgagctgtg gtcccgcgcc
      901 gacaaggcat gccgggtcat cggcccgatg ggcagcggaa agactctgcg gttcttcgcc
      961 ccgctcgtcc gcaactgggc cgggccggtc ctggccacct cgaccaagcc cgatctggtc
     1021 gaactgaccc tcgacgcgcg acagcgggac ggccgccccg tcgccgtctt cgacccgcag
     1081 aacatcgcgc cgagcctccc gcgcttccgg tggacgccga tcaacggcgc agccgacaca
     1141 gaggtggcga taatgcgcgg gaaggcgttc gtcgcgggct cgcgcacccc caacggtgcg
     1201 gcacagtcca gcgagggcag cgccttctac aaggggcagg cgtccaagat catcgctgcc
     1261 ttcttccacg ccgccgccct cgacggtgcc tcactcgact gggttctgcg gtgggcccgc
     1321 aagctgaccg acccggcacc cctcggcatc ctcaacgctc acccgggcgc cggcccaggt
     1381 tgggcggaca tgctccgcac ggccaccacg ggcgacagcc gcaccgtcgg caacaccgcc
     1441 tcgaccctcg acgcggctct cgaacccttc atgcaccagt cggtgatcaa cgcccttcag
     1501 ggagacggag aggaccccac ggacttcggc gcgttcctcg acgccggggg caccctctac
     1561 ctcctcggca aggacagcga ggtgaacagc gtcgcgccgc tgaccaccgc gatagccgaa
     1621 gaccttctgg atttcgcgga ggcgcacgcc ctcgcgtccc cggccgggcg gctcgacccc
     1681 gcactcctcg cggccttgga cgaggcaccg aacatcgcgc ctatcccctc cctccgccaa
     1741 cgcgtcgccg acggtcgggg ccgaggcatc acagtggtct acggcctcca ggcgtgggcg
     1801 tcggctcgtg cccgtttcgg cgaggacacc gccaaggagc tggcggcctt caccaacaac
     1861 gtcatcgtcc tgcccgggga caaggacccc gacttcctga aagacatgtc cgacctgtgt
     1921 ggtcaggtcg agcgagagcg cacgacgaag accacgtccg gcggagaccg cggcggccac
     1981 tcgacggcca cgcacatggc gctcgaaccc gtccttcgag gagacgagat caggggcctt
     2041 cccgaggggc acgccctggt cctcgcggac aacctcccgc cgatcgtcac ccggctcgac
     2101 ggcatgtgga cctgggattc ctgggccgag atcgagggtc acgtccgtga ccttcgagcc
     2161 gccaatgaag ccgagcggac cctgcgggct acggagaaga agaaccgggc caaggcccac
     2221 gcggtggcgt gggcaggccg tgaaggagcg gctgccgcat gatcgagacc ctgacccact
     2281 tcgagccttt tcccgagccg cccgcactga tcttggagta catcgcggag cggagcacgg
     2341 aggagtccgt ggccgccgac ggtcccgtcc cgtgggacat cggcgccctg tcagcagaac
     2401 tgatcaagcc gatgcccgcg tggctcgatt ccgtgtgccg ttggctgaac cggacgtacg
     2461 cctggcagcc gcaggacgtc atcccgccct gctgggcgaa gcacgagggc ctggcatacg
     2521 agatcgcggc cctggccttc gccaggggag acgcgtacgc ggaggcgggc tcgtccgtga
     2581 tctggcacga gcagtacgac cgcttcctca cccgaatgaa caagtcgttg ggcaaagcag
     2641 gcgacgaatg ccgcgtcggc aggcacgacg accgtccggc gcgtttccag ctcgcggcct
     2701 ggcccacggc caagggcgag gagacgggat ctgcgggacg agtcgaggag atggtggccg
     2761 gatgatgagg gacccgaaca tggtcttctc gacggaccct cgtcacggac tggtggcgcg
     2821 aagcggctgg gaacaggagg aagcccggac cgtgctccgt gatctcggtt gggagtggac
     2881 ggaggaactg cacgccctcg tcccaccgga cgacgtgccg gaggtcgacg ccggccttca
     2941 ggcagtggag gaactgcacc tgcatgggca ccggaccgga tacgccgcgg ggccttacgg
     3001 cacgatgcgg ttgaccctgg atcgcgcgga gcaggtgttc acgaaggtcg ccgcccggga
     3061 gcctggtgag gtcacccccg acccgggcgc gcaaaatgat cagcctggaa gagcggacac
     3121 caggcggcct acgtacgggg gagtgtcccc ttcagaaggg ccggttgaac ccgacgggcc
     3181 cgagtcccca gcaatctaga aagtcctaca gcaggagccc gtacctgtcc ttcagcgttc
     3241 gaggagccct aggggttcct cgaacgctgc tgccgttcgt tggccggagt gacgtccccg
     3301 gcgagctgct tcgctctgtt cgttcaggcg ggagcggggt cgaggagaag cgagtcgagg
     3361 atggcagctg tgccggtggg gtcggtcgtg tggtgcacgg tgcggatgcc cagggtctcg
     3421 gcgggcggca ggttctccgc gtggtcatca acgaagacgc actcaggacc ggtcaggtcc
     3481 agggcgtcaa gcgcacgctg atagatgagc ggcgacggct tccgtacgcc ctccagctcc
     3541 gacaagatca cggcatcgaa gaagtccgtc cacatgccct tgtcctcgta cgggttgtag
     3601 ggctcgatcc cgaacgagtt gctgagcatg gccaccttga tccctgccgc acgagcgcgc
     3661 ttcgcggcgg cgactatctg aggctccgga tggaggttgg ccagagcgcg ccgcatcagg
     3721 tcggtggagt cgataccgag gatgccgccg atgacacggt tccagtcctc ctgggttgcc
     3781 tcaccgacct ccagcgctgc gtagatcgcg acgccgtcgg gatgctcatt cagcgccgcg
     3841 aaatacgcgc ctggagtcaa tccctccgtc ctctcgaacg cctgcccgtt cagtcgcatc
     3901 cgagtggtga gcacaccacc gaagtcgaga atcagaccac ggtatggggc tggcaaagcg
     3961 gcctccttgc cgatctttcc tacgtgtacg cggtcccccg gccgcagggc gacaggggga
     4021 ccgttgagtg ccctccccag agggagagac ccccagtatc gcccctcccc gaagcacctg
     4081 ggcctacgct tgacacgagt gccctgtcca ctacggcgaa cggtcaaccc atggtgtatg
     4141 acggagagtt gttcagcatc ggccagcgga tcaagtggtg gcgtgagcgc cggggcttgt
     4201 cccaaaggat gctgggagac ctgatcggca ggtcagagaa ctgggtctac aagatcgaga
     4261 atgaccggat gcccttggat cggcttccga tcctgatcgc tctgagtaag cagctgcgat
     4321 gcagtctgga ggacctgacg ggcggctacg tgtccggaat cgttacggcg ggcacggagc
     4381 acgagcacgt tccgctcatc cgacaggccc tgtcgctgcc cgcctccctc cttccgcagc
     4441 ggatcgggtc ggttacctcc gacgacttcg agtcctcggt tacggacgcc tggaaggtct
     4501 acgagacgca ggctgacgac cggtaccgcg acgtcggcga gcggctgccc gccctgttgc
     4561 ggcagggaca cgccgctctg cgcgacgcct cgcctgagca ggagggcacc gtcctccggc
     4621 agctcatcag tctctacggc ctgcaccaga tctggcttcg ccgcgtcggt gaaccaacac
     4681 tcgcccgcat cgcggccgac cgcggcctct ccctcgctga caacgccggt gacccggccc
     4741 tcctcgcagc tgcggcctgg aacctggcct gcgttctcac ttccgccgga gatgtggaag
     4801 acagctacga acttgcccga cagaccatcg cccagtgccg gccgcacgac gactccaacg
     4861 cggagcactg gtccgcgtac ggcgcgctac acctgcaagg tgccgtcgcc gccgtacgcg
     4921 cgacaaaggg cccgagggcg tgggacctgt acaacggcgc gcagcaagcc gtggaccggg
     4981 tcggcgcgga cctcaaccac tggcacacgt gcttcggtcc gaccaacttc gccatgcacg
     5041 aggtacacct gaaggcggag gagggcgata ccagcgaagc gcttcgcgcc gccgatcacg
     5101 tcctcgtcaa cgaagaggtc ccgctcgaac gtcgaacccg gtacctgatc gaggtgatga
     5161 acctcaaccg catccagcga gacgactacg cgacggtgca cattctcggc aagctgctga
     5221 agcagtctcc ggaggagatc gtgttctcgc ccctggtcag ggaggcggtg gccgacctgc
     5281 tgaagcgcga gaagccgatg tggcgcgacg accttcgtga agtagcgaag cacatcgggc
     5341 ttgccgcgta ggcatatgcc aaccctgagc gttactcagc cctgattttt tctcaggggt
     5401 ggcgccttga agtggcccta cgtttacggg tcatgacgac aagtcacgct cagacggaag
     5461 ctggcgcggc gcccttaccg ccagccaagc gccacctccg ccttgctcgt gaggcgaagg
     5521 tcgcgcacac ggaggccggt cgtttcgcgg tccccctcga cctgcacgag ggggccgcgg
     5581 agcccgcgac cattccgctg gtcctgacgg ccgatgaagc ggttgctctg cacggcaggc
     5641 tcggtgccct cttcccgttc gcggaagggg acaaccgatg accacacgaa ctccctcaga
     5701 tcgtgagcgc cgccgcaacc tcgcagacgc ttcgatcacg ccgttgcccg cttttgccgg
     5761 gctgctccga cacgtcccgg gccagcagcg tcggacgggg ccgctcgctt cccttgacga
     5821 ccgggccgcc ccggaagacg gggcctcaca gatcgggacg gagcggtgat cggcccggcg
     5881 tcgcagcgcc cgaccgcaac tcgtgccggc ggcctggtgg aggagcgctt ctccatcacc
     5941 aagcactccc cgggcgagcg cccccctccc gtagacgagt cccgcgtccg cgccatgagg
     6001 ctcgtgaccc gcgaacgtct cacctcccgc ggtctgacct gcgtcgccga cgacgcgaca
     6061 ctcgtcgtct ctgagctgat caccaatgcc atcgtgcaca gcggtggcag gcaaatccgg
     6121 ctgacccttg acgtgcgcga tggcgtcctg cgcatccgtg tccatgacgg cgtgcccgga
     6181 cctcgcccca ctgctcagtg ccccgaggac gacgccgaga acggtcgcgg cctggtgctc
     6241 gtgcaagaga tcgcccgaag cagacagggc gcgtggggtg tcagcgacga cggcgccacc
     6301 acgtggtgcg agctgagttt ggtggcgtgc tgatgacgaa caccgcatta cgcgacgaga
     6361 cgactagccc ggagaccatg ccggtccgcg ttaaggaccc gacggtcccc acgaaccctt
     6421 ggactcctcc acacggtgag gaggaggccc ggcggtacct gagcgcagtg cgcgagtggg
     6481 caagcgtgga ttggaacgag gtgtacgacg acctcgacac catcctgcac ggcgaggaag
     6541 agatcagcca ccacgccgcg ggcccgtccg gcggagcacc attacccaac tacaacaacg
     6601 atgcccttac tcagcgcttc ctcatggcgc tcaagctgct tgtagctcgc gccttgcgag
     6661 acaaagccga cgagaagcac ccggacatcg ccgctctgat cgggcaggcc tgcacgctgc
     6721 gtgccgaggt agtggccggc gacgcggggc agaccatcgg actcgttcgg aagctggcgc
     6781 ggctcaccct cgatctcgcc gagcttctgg aagaggccgg gatcgtcagg gggctggtcg
     6841 agtgctgacg accaccaagg cttcgacgcg ttcgttcggc ccttccctct gccctgccga
     6901 ggaggcgtac gacttcgagc acttccggaa ccgccttgcc cggcccgagg tccttgctca
     6961 cgctgtcgcg gtacgcgtct tccgggcacc actgcttgcc gtgccggtcg gcggcccgcg
     7021 tcgcggcgga tacatgtcct tcgatctgct gtccctggca ataggggcac gcgaccttct
     7081 cacgaaccgg ccggggtttc cggacctccg cgtccgatgg tcgccgtacc gcgatacctg
     7141 ccacaccgtc gagtggggcg atcccgctcc cgggtggtgg gaggacgacg cggtcttcgg
     7201 ccgcttctac ggctacagcg agtccgccat cacctcgttt gtaggtgcac gcccacagac
     7261 accctcttcg gcaacctcca ctccgtgttc ccccacggct tcgtagtcgc cgaagagggc
     7321 ccaacttccc cacactgcct tgagaggacg acgagtacga tgtgccagca caccccgccg
     7381 tgtcccacgg ccgaggcttc cgaccgagag gccgcccgcc ccacggtggc ccaccctgaa
     7441 cagggctgga gcctgctgtg caacggggtg ttgctcttcg aggacaccgg cgagctgttg
     7501 ccggacggcc agatcgtcgc tccgcaccgg ccggtcgcgc tcgccgccgg gagcaccgcg
     7561 tgaccaccgc tccccagatc gtcgtgccct acatcaccgc ccgggagggc gaagaggccg
     7621 actcattcct caatctgcgc atgggccgcg gtccggacgg ccggccacgt ctccgatacg
     7681 tggatgaggc gccgccggac cgggacctca agggcgtgct ctgggcccgc tactccatgt
     7741 cgctcgacac cttcgggcag ccctgcggga caccgcgctg gcggatggtt cacccgcacc
     7801 gtcaacgcgt gacgatggcg ctgctgcggt gccaggtatg caccgtccag ttgaagcgca
     7861 ccgacggcgt cctcttcctg gaaacggcgg gtgaagaggg ctacgacggt ccagtgaaga
     7921 ccgcgcagcc gccggtatgt ctggagcacg cccggatggc ggcaggccgg tgcccacggc
     7981 tcagggcaag gggccacgta gcgcttctcg ccacccgttt cccgctgtac ggcgtgatcg
     8041 gccacgcgta ccagtggagc gcgaacggcc tacaggcact ctcggacatg gactccccca
     8101 tcccttaccg ccatccccag atcggcatgt tcctggcctc ccagctcgta cgggaactgc
     8161 gggagtacaa ggtcgtcaac ctggacgatc ttgtgcccgc cgcctagacg gccgcccggc
     8221 cctcctgagt ggtacagaca ggaccgccgg gcggctcacc accggcgccg gacctgcgcg
     8281 cgccgtccag cacgaacccg ccaactttcg gcggtccgac gagagcggag agctttcgcc
     8341 gatagcctcc cggcccccgg cacgcgtgcc ggcccacccg cccccgaaca cgaacgaccg
     8401 aaggaagtcc atgacgaaca cgaccgtcga gcccgacgag gcgacccgcc tgcggaacaa
     8461 ggtggtggac gagctctgcg cggacggcaa catctcctcg ccggagatcg aagcggtgat
     8521 gcgcaaggtg ccccggcacg agttcacccc cgccgacacg ccgctggaca aggcgtacga
     8581 cacgtacgcc gccgtgatca ccaagacgga cgagcacggc gtgcagctca gctccgtctc
     8641 cgccccacag atccaggcca tgatgctgga gcaggcccag gtgaagcccg ggatgcgggt
     8701 cctggagatc ggctcgggcg ggctgaacgc ggcctacctc gccgaactcg tcggcgagga
     8761 cggtgaagtc gtcaccgtgg acatcgaccc cgtcgtcacc gatctcgcgc gccagctcct
     8821 gaacgagcac ggctacggcc gagttcacgt cgtcaccgcc gacgccgccg agcccatccc
     8881 ggacctcggt gaggtcgacg tcgtgatggt gaccgccggg gcctgggacg tctccccggc
     8941 gtggaccgcg cagctcaagc agggcggccg gctcgtcgtc ccgctgcgga tgcgcggcct
     9001 gacccggtcg gtcgccttca tccaggtcaa gggcgagcac ggtccctacc tggagagcga
     9061 gtcggcgcgg atctgcggct tcgtcccgat gcagggctcg accgcccacc gggaagaact
     9121 cctcctggtc aacggcaccc cggagatcgg gctcaagttc gatgacggcc tgccggccga
     9181 cccgcaccgg ctcgacaacg ccgtcacgtc tccgcgccat gaactgtgga ccggcgtcac
     9241 tgttcgcatc caggaactca tcgacaccct tcagatggcg atggcgatct ccctgccggg
     9301 cttctgcacg atggccgtcg atgagaactc ggactcgggg atggtcgccc ccgtgaacaa
     9361 gcggttcgcc ctcgcggccg tcgaggacga caccttcgcc tacctcgtca cccgccgcac
     9421 cgaggacaac aagcacctgg agtacggcgt gcacgccctc ggcccgcacg cggagcagtt
     9481 cgccgacaag atcgccgacg tgctccgcga ctgggaggcc aaccggcgcg gcggccccag
     9541 cccggtcatc cgggtctatc cggatggcac ccccgatgac cagatcccag ccgaccgggt
     9601 catcgacaag gtgcacagcc gggtctcgct ctcctggccc tcggcgtaac accgggagcc
     9661 aggtaatccc gcaccacccc gacaagaaga agggcacatc atgacgagcg ccactctcgc
     9721 cccgcccccg gtcgcgcccg cgccgtcggc ggacctggac gacgacttcg cgcccctgga
     9781 cgtgaaggtc gtcatcgccg agcactcgta cggccatctc atgtgctcca cgggcgacgg
     9841 ctgcggcacc acctgcgcga ccggtgcctc cgcctgcggt tccttcacgg aggacccggc
     9901 ctgatccagg ccgaccccct cacctgtggg ccgggcgaag cgcttcgccc ggcccacagg
     9961 cccctctccc cctccccgcg ccgcctcatg gaagggcctc atggcttccc gagcagccgc
    10021 cggataccag tggcaaggcg ttgcgatgct gcgcgccacc accagccccg ggccggcaga
    10081 catcccccgt accctcgacc tggacaacgt ggccgtcacc cgcggatggc tgaaccgcat
    10141 ctggcagcgc gaggacttcc gcagcgcgct ggagctggcc acccccgtcc tgtccgacgc
    10201 catcgaggca gtcgtccggg gccggcagac cgagccccgg cacgtccgcc gcaccgcgct
    10261 gtcgacggtc tcctacctcc tacggtggca gcaccggccg accccgctcg ggctgttcgc
    10321 cggcaccgcc ccggtgtcgg tcgggccccg agcgagtgcg cggtggcgcg acaagcaccg
    10381 cgcgatgatc cggccggacg ccgaatgggt caccgacatg gttctccggc tccagcgcac
    10441 ccccgcgttg ctgaagcggt taccgctcgt cgccaacaac gccgcccgcg cacgcggtga
    10501 ccggctcgtg gcaccgggtc cgccctccga cggccacgcc gtcctgctgg ccccggtcga
    10561 gatatccgtc cgcaacgccc ggccggtggc cgccgccatg gacgcggccc gcacccccat
    10621 cctctacagc ggactccaca gccacctgcg cgaccgcttc ccgcaggcga caccggagaa
    10681 gatcgacgcc cttctcacca gcctggtcga gcagcagttc ctcatcacca gcctctgggc
    10741 gcccatgacc accgtggacg gctttcagca cctgtgccgc gaactggacc ggctccaggc
    10801 ggacgacgtc cccgaggtgc gggacctggt ccacgcgctg tacgcgctgc gcgacgacgt
    10861 gtccgcccac cagccgacgc tttccgacac cagcgtgagc gccgtcgccg cgcggatgcg
    10921 cgcactcacc accgtcaccc cgaccccgct gctcattgac accgccctcg actgcgagac
    10981 ccagctcccg cagcccgtga tcgcggaagt gcaggcagcc gtgtcggccc tctaccggac
    11041 caccccgcag ccctacggct accagcactg gcgcgactac caccgccgct tccgggcccg
    11101 gtacggcgtc ggggccctgg tgccggtaat ggacctggtc gccgacagcg gtctgggcct
    11161 gcccgccgga tacgtcggct ccgaacgcgg cgccgccctg aaggtgcgca ccgaccgcga
    11221 tgaactgctg ctcgcgctga tgcagcaagt cctcctggac ggccgcgatg aactgcggct
    11281 gacggacgac atggtcgacg ccttggagaa ggccgccgga gaggacgagc ggctgttcgt
    11341 accccgggtg gaggccgcct tcgaagtcca ctcacccagc acccgggcac tgtccagcgg
    11401 caccttcgat gtcctcctca ccgcggtccc ccgccccggc agcagcatgg ccggccggtt
    11461 cgcccacgtc ctgccgcccg agcatcagga cgcgctcgcc gccacgtacc acggggcgcc
    11521 ggacgccctc acggcgcagc tcgtgttccc gccgcgccgc caccgcaacg agaacgtcac
    11581 ccgtacgccg cggctgctgc cgcacgtcat cgagctgtcc ggccaccagg agacggacga
    11641 gacaacgatc ccgctcgccg acatcgccgt caccgcggac ccgcgcagct tccacctcgt
    11701 gcagctctcc accggccggc gcatcgacgt gcgggtcctg cacgccctgg agggcgggac
    11761 acagacccca ccactggccc ggttcctcgc cgaagtggcc aacgggcggt acgccgccta
    11821 caagccgttc gacttcggcg ccggcgcccg gctcccgttc ctcccccggg tgcgctaccg
    11881 ccgcaccatc ctcacgcagg cccgatggct gctgagggcc gacgacctgc ccggccgcaa
    11941 agcctcgacc gaggagtggg aggacgcctt caccgcctgg cgggaccggc tacgggtccc
    12001 catgcaggtc gcgatcatcg agtacgacca gcgccttccc ctcgacctgt cccacccggt
    12061 ccaccgccgg gccctgcgcg cccacctcga caacgcccgg cgcctggagc tgcgcgaggt
    12121 cccggacgca gacgcccacg gctggatcgg acgggcacac gagatctggc tctccctggg
    12181 ccggttgcag ccggacaccg ccgatgtgcc ccggccgcgc cccgccgccc cgccggcccc
    12241 cgggcggcac cttccgggcg ccggtgacgt cctgctcgcg cagctccacg cccacccgcg
    12301 ccgctacgac gagatcctga gccgccacct gcccagcctc ctcgccgcgt tcggcgacac
    12361 cccgcccctc tggtggttca cccggcaccg ggagatggcc cgcccggacg ccgaccagca
    12421 cctcgacctc acgctgcacc tgccgccgga cgcatacggg gccgccgccc aacacgttcg
    12481 tacctgggcg gacagcctgc acgggaccgg tctggcggcc gggctcgtcc tggctcccta
    12541 ccagccgcag accgggcgct tcggcagcga ggcagccatg gacgccgctc accaggtgtt
    12601 cgccgcagac tccgccgccg ccctcgcaca gatccagctc accgagcgca ccgacgccgt
    12661 cgccccgcag gccctcgccg cggccagcgc cctgcacctc gtcacgcccc tggcgccgga
    12721 caccgcggcg gccgaggagt ggttggtgcg caacctcccc cagggcaagg ggcgactgaa
    12781 ccgggccctg cgtacccagg tgctcgaact cgccgcgccg aacggcgcct ccgcgctcgc
    12841 ggccctcccc ggcggctctg cggtcgccga agcatggcgg gcccgcgtcg tcgccgtgga
    12901 cacctaccga aacgccttga ccggccagcg tgatcccctc ggcgtcgccc ggtcgctcct
    12961 gcaccagcac cacgtccggg ccctgggcgt cgacccgcgc gccgaggaga ccacgatccg
    13021 gctcgtacga actgcggccc tccagcacag gatggcggcc cgatgaccgc gccggccgtc
    13081 accactgcgg cgatcctgga gcagtacacc gcccgcctcg cacaacccgc tccgccgtcc
    13141 ccggacgagc cttgggcggt gcagtccctc gccgacggcg ccgccggaat cagcctgctg
    13201 cacatcgaga tggccagccg tcacggcggc tcctggcgcc ccgcccaccg atggatcacc
    13261 gccgcagcgg ccgggcacat cagcgcggcc gacaccgccg gactgttcct cggcgccccg
    13321 gccctcggct tcgtcctcac caccgtcccg ccgtccttcc agcacctgta cgaaccggcg
    13381 cgccggaccc tgcaccagca catcaccgac ctgacccacc gccgcgtgga cgccgcgctc
    13441 acccgcatcc gcaagggcga cctgcccacg ttcgccgaat acgacctgtt ctacggcctc
    13501 accggcatcg gggcgtacct cctgcggacc gaccccgaag ggctccccct ggaacgggtc
    13561 ctgaagtacc tcgtggccct gacccgcccc cttgtccccg acggccgcgg cctgccgggc
    13621 tggtgggtcc gccacgaccc ggcccgtggc gagtccctcc actacccggg cggccacggc
    13681 aacttcggtg ccgcccacgg catcaccggc ccgctcctcc tactggccca ggccgtgcgc
    13741 cgcggcatca ccgtcagcgg ccaccgcgaa gccatctgga gcatctgcga acaccttgac
    13801 gcctggtgcc agctcagtcc ctccggtccc tggtggcccg agcacatctc gcgccgcgac
    13861 ctcaacctcg ggcgcccgca ccacgacgct cccacccggc cgagctggtg ctacggaacc
    13921 acgggcatcg cacgagccgg gcaactcgcc gggctcgccc tgcgcgcccc cgacgtccag
    13981 gcgttctacg aggacgccct gtaccgcgcc ctgaccgacc ccgaacagct cgcccacgtc
    14041 accgactcgg gtctgtgcca cggctgggca ggcatctacc agaccgccac ccgcgccgct
    14101 gccgacgccc gcgacccccg ccttcagacc ctcccgaagc gcctcggcaa catcctcgca
    14161 gcgaacgccc agccgtgcct tcccgagccc ggcctgatca acggcgacgc cggtaccgcg
    14221 ctcgccctca ccacctacgc ctcacagcag gccccgatct ccggatggga cgcatgtctc
    14281 ttgatcaact gatcttgacg gagccgagcc cggtccagcg cgcggtctcc gctgccctca
    14341 ccggcttgcc gatccccgaa gtcgcagctc agtacgggat ggaaccgacg atcctgtccg
    14401 acgccgtggc ggtctacgac caagccggcc gggaggccct ggcccgccac gccgccgcca
    14461 ccgactggtg gcatgtgtac ctccacttca ccgactggac ggccgccgac accaccttca
    14521 ccacgcacgt gctccccgtg ctcggggagg cagaggccac cgggctcatg agcggctggt
    14581 ggtacacccg caagcacccg tgctggcgcc tgcgccttcg tctacagccc gaggccggaa
    14641 ccaaactgac cctcggcgac ggcttcgacc gtcttgtctc cgacgggcat ctgcaccggt
    14701 ggtggcccgg gatctacgag ccggagaccg cagcgttcgg gggcgcggtc agcatgatgg
    14761 ctgcgcacgc gctgttcgtc accgacagcc gagaggcgca gcaactaagg cagcgcgggg
    14821 acctggccgt gggaccgcgc gagctgtccg ttctcctctg cacgatcatg atgcgcgccg
    14881 cgggtctgga gtggtacgag cagggggacg tgtggcaccg cgtcatcacg gaagagcacc
    14941 gatcggccgt gagcgacgtc ccggcagacc ggctcgacgc ccgcgcgcag gagatccggc
    15001 cgctgctctt cgccgacagt gatgtcctgc tgcgccccgg cgggctgttg gaacccgtcg
    15061 ccgagtgggc cgccgccttc cgcagcacgg ggcaggaact ccgccgtgcc gtacaggacg
    15121 ggacgctcga ccgggggctg aggcaggtgc tcagctatca cgtgatcttt cactggaacc
    15181 ggcttgggct gtccatgcgg ggacagagcg tcttggcctg ggcagcgagg gcggcgatcc
    15241 tgcaccggga aagcgggaca taggtgggcc gcgagccgtg taaaccgcca ggggccacca
    15301 gctgtaggcc ccggagaagc gacccatagt cgtgcgagat aggacttgcc atgaccgttc
    15361 catcgcggca gaagcaatga gtgagcctcg gattgctgtt cgggggccac ccacagggct
    15421 tcgagctccc gccgcccgtc tccggtggct acggcgtctt cgaacggccc cacccgtctc
    15481 cagggcagat gaccggtggg gccacttcaa gccgcccctc gatcttcacg aagtgcggcc
    15541 gactcgggcc gccctggtgg ggccgttcga agacgccgta gccagtctcc gggcccccgc
    15601 ccgccaccga ggtgaccgcc gatgagcggg aggccaagga ggtgatgcgt acggccggct
    15661 acgagccgag ggggccttac cccggtgccc gctcgatgcc ttggccgagc gagtgcaccg
    15721 actgcggggc gtcccgtaaa ccctcgctcc aggcccaggg caccacgctg cggatcctgt
    15781 caggcaaggt gatcaccacc gcccaggatc actggttccg cagggcgatc gatgggccga
    15841 ccgtgatcgc atccgactcg gccgaggcgg gcatcgacac gcacagctac aggagatggg
    15901 actggacgag gatcaggcgc agcggctggt gcagggtgag ctcgacatgg gcgtctcgca
    15961 ctgcaaggac ccgtgggact caccgttcag cccgcgcggc gagttgtgcg cggtcgcgcc
    16021 gctgcgctgt ctggaatgcc gcaacgcgtg ggtgctgccc agccaactgc cgcaactgat
    16081 gctgttcgcc gagcatttgg agagggtgcg ccgcaggctc gatccagtga cgttcacccg
    16141 ccagtggggc cagtcctacg tcaacctaca ggccgccctg gacgagcgta ccgatcagga
    16201 gaaggccctg gcacagcagc acatcgacgc ggggacgggc ccgtctggac ctgccgctgt
    16261 ccgcgcacgt ggagttcgac gcgtgatcat ccccaatacc ggcgggcaca cacattccct
    16321 tttccggcag gacaccgatc agcccgggcg cctgccgatt gcgggcagga agcggccggt
    16381 acgtgcggcg tactgcacgt acgcggggcc gtggacacga cgcaggtagg gctcctcgac
    16441 atagcggacc tggatttcca ggccgaccag gagcagcagt gggccgggca gcgcgatgag
    16501 gttgggaacg aggagggcca ggcccgccgc ccaggcgagg gcagcggtgt agatcggatt
    16561 gcggacgagg gagaacgggc catgggtgat caaggcggtg cgctcggccg ggtcgacatc
    16621 gtcgcgccag gaggcaccca tggcgttctg cgcgccgacg acggcggcga tgcccagcgc
    16681 ggccagcact gcgcccgacg cccgaagacc cggctggtcg agaacggggg ccgccggaag
    16741 acccagcagt tcggcaacgg gagcagccac ccccgtcagg agactgccgg ctatcaaggc
    16801 ggcgcgggcc cactgctgcg caggccccgc cgcacgggcc cgccggacgc cggtatcccc
    16861 agtccggtgg tactggatga ggatcctggc caccccggcc agcagcaaga acgcggcgaa
    16921 caggacaagc gcaaggacgg ccacgacttc tcacctcctc cttcgtgtct tcgtgtcccg
    16981 ccgtcaggcg gctggggaac tcgccctgcc gggtttgggg gccgggcggc gccaggacag
    17041 agcaacgacg gccagaccgc cgcagacgat gaagacgtcg gcgaggttga aggtgggcca
    17101 ccagccagtg tgtaggtagt cggtgacgac cccgtcgccg gcacggtcga ccaggttcgc
    17161 ggccgcaccg gcgaggatca cggcgagtgc cgcggccgcg gccttcgact gcggggcggt
    17221 ccgccaggcg aacacgccga ccccggcggt gatcagggca gtgaaggcga ccaccaccca
    17281 ggagggcaga gtgtcgccca tggagaaggc gacaccgggg ttgaacgcca ggcgcagctg
    17341 ggcgaagtcg gggccgatcg gtgcgtcggc cagggcgctt tgggcccagg tcttcagggc
    17401 gaggtcggct gcggccaggg cggcggcgcc ggccgcgagg gccgtgcgcc gccgggccgc
    17461 cgaggacacg cgagtggtgt gctcgggcat atttcagact cctgccgccg cggggacggg
    17521 ctggtcggct gccttggcca ccggggccgg gggcagggga cgggtgcgtc cggcgcggac
    17581 gccgttgccg atgacgacga cctcgaagag ttcgtggacg gcgacgacgg cggccaggct
    17641 catgacgccg aacgcggcga gcgggatgag cagggtgatc aggcccaggg acatgccgac
    17701 gttctgcagc atgatcgcgc gggagcggcg ggcgtggtcg agggcctggg gcaggtggcg
    17761 caggtcctcg cccatcaatg cgacgtcggc ggtttcgatg gcgacgtcgg tgcccatggc
    17821 gcccatggcg atgccggtgt cggcgctggc cagggcgggg gcgtcgttga tgccgtcgcc
    17881 gaccatcgcg gtcggccgct tctcgcgcat ggaccggatg agggtggcct tgtcctcggg
    17941 gcgcaggtcg gcgtggacct cggtgatgcc ggcctgggcg gccagggcgg cggcggtgcg
    18001 ctggttgtcg ccggtgagca tggccacggt gtagccggag gcgtgcagtc gggagacgac
    18061 ctcggcggcc tcggggcgca gttcgtcgcg tacgccgatg gcgccgatga cgtgtccgtt
    18121 gtattcgacg aggacggcgg tggcgccggc gttctgcagg gcggtgatgt cgtcggcgag
    18181 ggtgccgggc tcgatccagc cggggcggcc caggcgtgcg gggcggccgt cgacggtgcc
    18241 ggtcagtccg gcgccggtga ccgcttccac ggcgtccgcg tgcgggtgct ggggtgcggc
    18301 ggccaggatg gcgcgggcca gggggtgctc gctgcgggac tccagcgccg cggcgatctc
    18361 aaggacgcgc ttgtcgctgc ggccgtcgac ggagacggtg cggatgacgg tgggttcgtt
    18421 gcgggtcagg gtgccggtct tgtcgagcgc gacggctcgg atgcggccga gggcttcgag
    18481 ggcggcgccg cccttgacca ggacgccgag gcggctggcg gcgccgatcg aggcgaccac
    18541 ggtgaccggg acggagatcg cgagcgcgca cggcgaggcg gcgacgagga cgaccagggc
    18601 gcgttcgatc caggtctgcg ggtcgccgag gatgctgccg gtgacagcga tgatcgcggc
    18661 gaggaccatg atgccgggca ccagcggctt ggcgatcttg tcggcaagcc gctgggcggc
    18721 gcccttgcgg gactgctcgg cctcgacgat cttcacgatc cgggccaggg agttgtcggc
    18781 cgcggtggcg gtcacctcga cctccagcac accggtgccg ttgatcgacc ccgcgtacac
    18841 cgcctcgccc acgcccgcct cgacggggac ggactcgccg gtcagcgcgg agacgtcgag
    18901 cgcgctgcgg ccggagcgga tcgtgccgtc ggtggccacg cgctcaccgg gcttgaccag
    18961 cagcagatcg cccatcttca gggtggccgg gtccacggtg acctgggccc cgtcgcgcag
    19021 cacggtggcc tcgctgggca ccaggtcgag cagggcgcgc aggccgcggc gggtgcgggc
    19081 cagggagtac tcctccaggc cctcgctgat ggagtagagg aaggcgagca tggccgcttc
    19141 ctcgacctgg cccaggatga cggcgccgac ggcggcgatc gtcatcagcg tgccgacgcc
    19201 gatcttgccc ttggccaggc ggcgcagggt gccgggcacg aaggtccagg cgccggcggc
    19261 cagggctatc gcgttcagga ccagctggac cgtctccgac ccgcctgcca ggccggtgag
    19321 gaagccggcc agcaggaaca ctccgccgac ggcggcccac tgcagttcgc tgacctgcca
    19381 gatcttctcc ggcgcggcct cttcggcctc gtcaccggtg cgcggctcgt cgccgctgca
    19441 tccgcaggcg tcacccatgg ttgttctcct tgcgctgagc ggccgccggg gtgcggccgt
    19501 aggtggggca caggtcgact gcctcgccgg tcgcggccag caggtcctcg gccgaggcca
    19561 gcaggtccag cagctcgggg cgggccagga agtagaacga ggatcggccc tcggcgcggg
    19621 agtcgatcag tccgcactcg cgcaggcagg ccaggtgcgc cgagaccgtg gactgcgcca
    19681 ggccgagcgc cttcaccagg tcgaccaccc gcgcctcgcc ctcggccagg cgcatcagga
    19741 tcgccaggcg ggccggctcg cccagggagc ggaacagggc cacggcagcc gacggcgccc
    19801 cgcacgacgt cgtggtggcc gccggggcca cccccatgtt attcatcgtc atgcaacgat
    19861 gatagcgaac ctggacgatg cattgacaag gggccggacc gcactgatga actaggtccg
    19921 aggcgcaccg cgcgcgcctc gccttcgggg atgccaccga agggcggccg cccgtgatga
    19981 tggacagcga gtgcagttga cgcccaccct gcccgcgaca ccgcactcac gacgggactg
    20041 gacgaatcgc ccggatttca cacaacgaag ccgcgaaggg cgcgaaagtt actttctggt
    20101 ttcatcgcca caggtcgatg atatcgctag gatccgatat cggaacggtc ggcggggggt
    20161 cggccgcatc gcctatgggg gttgagatgc acgttctgat tgttgaggac gaccagcgga
    20221 tcgcggatgc gctcggggaa gccatgcagc gattcggcca cgacgtgacc agggtggcca
    20281 ccggtcgtga ggcgttgacg gtggcggaga gcaccgagtt cgttctactt gacctggggc
    20341 ttccggactt ggacgggcag gaggtctgcc gccggctgcg ggagcggtcg tgggtgccga
    20401 tcatcgcggt cacggcccgc gcggaggaag tggaccggat cctgctgttg caggcagggg
    20461 cggacgacta tctgatcaag ccctacagta tgcgcgagct gctggcccgg atggatgcgg
    20521 tggcgcgccg ggtcaccggc cccgctgccg ccgccggtgg cgagtcccgt gaggaccgct
    20581 gggctgcggg tcctttggtg ttggacctgc gtactcgtca ggtcgaggtg cacggtgtgc
    20641 cggtgggttt gacgcggcgc gagttcgacc tgctggcggc cctcgcggcc gacgcggggg
    20701 ccgtccgtgc ccgcgaggac ctgatcaacg aggtgtggga cgtcaactgg cacgggtcga
    20761 ctaggacgtt ggacgtccac gtcggatctc tgcgcaacaa gctcggcgtc cgggagtgga
    20821 tcgagtcggt gcggggagtc gggttccgcc tggcggtgcc cgatgcggcc tgacgccagc
    20881 gacagggcgg ggccgcgccg cgggttcggc gggcagaccg gatggaaggt aggcagcgtg
    20941 cggggtcatc tggtcgctgc cctggtcgtg ttaccgacgg tggtgctggt ggtgctcggg
    21001 ctcccgctgg ccgcggagcg cgacgaccgg gcagtgcggc agctcacgca gatccgcacc
    21061 cagcaggcac gggagatgaa ggacctggcc gccggtgtgg tgcgcagcgg cgactcggac
    21121 cgggcccgca ggcacatcgc cgacttccag gaccgtaccg gcggacggat ccagctctat
    21181 gacacgacgg gccgggcgtt actgggggcg ctgtgcatcc tctcgcccga ggagctgcgg
    21241 gacgaggagc cggtacaggc ggcgctcagg ggtgacttca gggactcggc tgagcagcgg
    21301 gtgtcctggc aggcggggga gctggtggtc gccgtgcccg tcgtcgacgg tggggtgctg
    21361 gtgggagtgg tggtgatctg ctcgttcctc gacgacctgc agatcgacgt gctgacggca
    21421 tgggtcatca tcgctgtcat cgctcttctg gcactggcgg tggccgcctt cctggcggag
    21481 ccgctggccc gttggatctt gaagcccatc cggtacttgg agcgggccgc gctggatttc
    21541 gccgccgggg atcacgatgc gcgggtccct gtggatcagg ggccgccgga gcttcgggtg
    21601 ctggcggaga cgtttaatca tctggcacag caggtccagc atcaggtcca ggtccagcag
    21661 tcgttcgtcg ccgatgccag tcatcagctg cgctcaccgc tcgtggcgct gtccttgcgt
    21721 ctggagaacc ttgaaccgta tgtcgacaag gacggcgccg cgcgcctggc tcaggcgctg
    21781 gccgaggcgg agcggatgag ccgcatcctc aacgctcttt tactcctggc ccgttcggag
    21841 accgaggatc agcccgctca cccggtcgac gttctcgcgg tgctggagga gcgggtggcg
    21901 tcctggcgga cggtggcggc cccccgggcg gtggagatcg acatcgtcga ggggcgcgag
    21961 ctgctgggcg cggcgatccc gggcacgctc gaccagatcc tcgacgtctt cctcgacaac
    22021 gctgtgcgcg tctccccaag gggcagctcg atccgattgc gggtcgtggc cgacgagggg
    22081 gtcgtggcgg tgcagtgcca ggaccagggg ccgggcatga gcgccgcgga tcgctcgcgg
    22141 gcttgcgacc ggttctggcg tggccccgac gccgaacccg gtgagggatc cgggctgggg
    22201 ctggcgatcg ccgcgagtct ggcgcgcgcc aacggcggcg aggtgctgct ggagcgtgca
    22261 cccgccggcg gcctgcatgc cgaggtgcgg ctccccaact ggcagccagc cctcacctgc
    22321 tcgggtcccg ccgcactcga atcgaggcgg aggtgatctt gtcccctttc ctgtacgtgc
    22381 cttgcatgtg cgctgccggt ttgctgacct gcggctcttt acgctgacgc cgtgcccgca
    22441 gcgtgacgca ctgactgcac gcgcggatga atgtggcagg cgtccctgcc cctccggtgc
    22501 ccactgtgtg cgccggccct tgatttcttc catctgtcgg ccccgtcgtg ggccggactc
    22561 accccctagg aggaggcgtg ggaacccgac ccactgcccg caccaccgtg acaaccgaac
    22621 cggccagccc tgctccgcca ccaccgtccc ccgcgggact cgcgcgcttg ggcacatggc
    22681 tcgcccggcg ccgggtgctg gtactccttc tcaccctcgc cgcactcgtg gtcgcggttc
    22741 ccttcggctc cgacgtggag agccgcctct ccgagggtgg catcaccgcc cccggctcgg
    22801 aagccgcgcg cgccgatgag ctgctcaaca cccgcttcga aggcggctcc ccgcacctgg
    22861 tgttcatcgc caaggccgcc agttccgtcg acgcagccga cgccgcgaag gagggccagg
    22921 ccctgaccga ccgcctggcc aaggaaccgg gcgtggtgca ggccgcctca tactggtctc
    22981 tgggcaactc cgaggcactg aaggccaagg acgggaaatc ggccctgatc atggtgcgac
    23041 tcgccggaga cgaggaccag gtccgcaagc acgccaagcg cgtgatgccc accgtcatcg
    23101 gcgagcaggg cccgtttaag ctgaccgcca ccggggccac cgcggtgcgc atggagatcg
    23161 agaagcagag cgaggaggac ctggtcaagg ccgagatgct gtccgcgcct ctggtcctga
    23221 tcatcctgct gctggtgttc ggcagcgtgg tcgccgccag cacaccgctc gccgtgggcg
    23281 tgctggccgt gatcggctcg ttcgtcgtcc tgcggctgct cgacatggtg gtccaggtgt
    23341 cggtgttctc ggtgaacatc accaccgcgc tgggcctcgg cctggccatc gactacagcc
    23401 tgttcatcgt cacccgcttc cgcgaggaac tggccgcggg gcgtgaggtg cacccggcga
    23461 tcgccgagac catgcgcacc gccggccgca ccgtgctgtt ctccgcactg acggtcgccc
    23521 tgtcgctgtc ggcgatgctc gtcttcccca tgtaccacct gcgctccttc gcctattccg
    23581 gcatcgcggt ggtggccctg gccgcgctgg gctcggtcat cgtcctgccc gccctgctgg
    23641 cggtgctcgg ccgccgggtg gatgcgtgga acgtactgtg gtggcgccgc aagtcgaaga
    23701 acagcggcgc gcgcagtgac cgcgaagggt tctggcaccg gctggccatg gccgtcatgc
    23761 gccgcccgct gcccttcgcc ctgaccgtga ccgcggtact gatcgcgctc ggcatcccct
    23821 tcctgcgggt cgagttcgcc gacagcgacg accgggtcct gcccgccagt tctgccgccc
    23881 accagggcgc gcaggtgctg cgcgagcagt tcgacagcca ggaaggctca cccatcgccg
    23941 tcgtcctgcc cgacctggac ccccagacgg actccaagga cgtggccgcc tacgccaccg
    24001 cactgtccaa actgcccgat gtgacccggg tggacgccgc caccggctcg tacaacgcgg
    24061 gccgtgaggt ggctccgccc agcgaaatct cccagcggtt cgccgccaag ggcacgggat
    24121 ccggcacctg gctgtcggtg acgtccgaca ccgagccgta ctcccagcgc ggcatgtcac
    24181 tggtctccac cgtgcgagcc gtcccgtcgc cctcagaaag cctggtcggc gggcaggcgg
    24241 ccctgctggt ggactccaag gacaccctgg gcgacaaatt gccctgggcg ctgggcatca
    24301 tcgccgcctc caccctgctg ctgctgttcc tgttcaccgg cagcctcctc atcccactca
    24361 aggccatcgt gctgaacctc ctcagcctca ccgccacctt cggcgccatg gtctgggtct
    24421 tccaggaagg gcatctgcgc tggttggtcg gtgacttcac cgtcaccggg gcgatcgaca
    24481 tcgacacacc ggtgctgatg ttctgcgtcg ctttcggcct gtccatggac tacgaggtct
    24541 tcctgctctc ccggatcaag gaggagtatc accgcactgg cgacaacgtc tccgcggtcg
    24601 cgtggggcct ggagcgcacc ggccgcctgg tcaccgctgc ggccgtcctg gtcgctaccg
    24661 tcctgctggc atttgccacc tccggactca ccccgctgaa actgctcggg gtgggcctgg
    24721 cgctggccgt catcgtggac gccactctgg tacgaggcat cctcgtgccc gccttcatgc
    24781 gcctggccgg ccgcgccaac tggtgggccc cccgcccact cgcccgcctg cacaagcgca
    24841 tcggcctcga cgactgactc ccctccaccc tccagcacct acctgccgcc ccggcgtcct
    24901 cgacgacacc ggggcggcct cgtgtccctg gcatccgccc ggctggcaag ttcaaggaac
    24961 gacacattcc cattcatgcg aagccctgtt cgagagctgc atatgcgttg ggcgggttct
    25021 gcatggccgg ttcgtagcgt catgggtgtc gcctcaagca cggcccaacc agcctgtggt
    25081 aagcggcagt tcgttgatca gcacacgaca cggtggggga cgccgggaat gaagttcttg
    25141 caacgcgaac gcgccgctct tgaagaggcg atgcccggac tggaccagca actggccgac
    25201 cactcactca tggacctgga gagggccggc gggccgggac tggccgcctt caccgaggcc
    25261 ggc
//
