LOCUS       NZ_CP065054            22835 bp    DNA     circular CON 17-MAY-2024
DEFINITION  Streptococcus equi subsp. zooepidemicus strain SEZ13 chromosome,
            complete genome.
ACCESSION   NZ_CP065054
VERSION     NZ_CP065054.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus equi subsp. zooepidemicus
  ORGANISM  Streptococcus equi subsp. zooepidemicus
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2150055)
  AUTHORS   Borlee,G.I., Lakin,S.M., Kapuscinski,M.L., Abdo,Z., Stenglein,M.D.,
            McCue,P.M. and Borlee,B.R.
  TITLE     Complete genomes of eight Streptococcus equi subsp. zooepidemicus
            strains isolated from mares in estrus with endometriti
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2150055)
  AUTHORS   Borlee,G.I., Lakin,S.M., Kapuscinski,M.L., Abdo,Z., Stenglein,M.D.,
            McCue,P.M. and Borlee,B.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2021) Microbiology, Immunology, and Pathology,
            Colorado State University, 2025 Campus Delivery, Fort Collins, CO
            80523, USA
  REMARK    Annotation added by submitter
REFERENCE   3  (bases 1 to 2150055)
  AUTHORS   Borlee,G.I., Lakin,S.M., Kapuscinski,M.L., Abdo,Z., Stenglein,M.D.,
            McCue,P.M. and Borlee,B.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2020) Microbiology, Immunology, and Pathology,
            Colorado State University, 2025 Campus Delivery, Fort Collins, CO
            80523, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Coverage                   :: 246
            Sequencing Technology :: Illumina NextSeq;Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015689395.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 02:47:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,059
            CDSs (total)                      :: 1,970
            Genes (coding)                    :: 1,933
            CDSs (with protein)               :: 1,933
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 16 of 37
            Pseudo Genes (incomplete)         :: 20 of 37
            Pseudo Genes (internal stop)      :: 16 of 37
            Pseudo Genes (multiple problems)  :: 14 of 37
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:11:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1904069
            Orig. end                         :: 1926904
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP065054.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22835
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="10"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22835
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22835
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12835](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12835)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    639..654
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.28"
                     /tool="antismash"
     gene            810..1178
                     /db_xref="GeneID:83705625"
                     /locus_tag="I2432_RS09060"
                     /old_locus_tag="LJFMMFNO_01811"
     CDS             810..1178
                     /codon_start=1
                     /db_xref="GeneID:83705625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303676.1"
                     /locus_tag="I2432_RS09060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01811"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_041781483.1"
                     /transl_table=11
                     /translation="MKYPRFEFYTRPNGRTEFIEFLQSIPTKDKQKLLATISVIQEQGL
                     LVAQRMEWVKKLDSDIFEIRSKVSSNIQRALYFHVVDDRFIITHGFTKKTQKTPTTEIH
                     HAKALKKEFEENYNNDNH"
     gene            1165..1440
                     /db_xref="GeneID:83705626"
                     /locus_tag="I2432_RS09065"
                     /old_locus_tag="LJFMMFNO_01812"
     CDS             1165..1440
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002959518.1"
                     /locus_tag="I2432_RS09065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01812"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_015057304.1"
                     /transl_table=11
                     /translation="MTTIKFDDFLNEELKNNDFKFGYLAEKAILESAIAVYNARQKAGL
                     SQRELADLSHVPQSTIARIERGNNTSIETMSKIAFALNKHLTIHIG"
     gene            1582..2838
                     /db_xref="GeneID:83705627"
                     /locus_tag="I2432_RS09070"
                     /old_locus_tag="LJFMMFNO_01813"
     CDS             1582..2838
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705627"
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057303.1"
                     /locus_tag="I2432_RS09070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01813"
                     /product="ISL3 family transposase"
                     /protein_id="WP_206158737.1"
                     /transl_table=11
                     /translation="MEHLNNTTLLIGIKDKHITLTKAIQHDTHIKVIATLDYNPPKCKH
                     CRGKQIKYDFQKPSKIPFIEIGGFPSLIRLKKRRFQCKSCRKVTVSETTLVKKNCQISE
                     MVRQKIAQLLLNREALTHIASKLAISTSTVYRKLKQYHFREDYANLPEVLSWDEFSYQK
                     GKLAFIAQDFNTKKIITILDNRRQTTIRNHFFKYSKEARNKVKVVTVDMSGSYIPLIKI
                     LFPKAKIVLDRFHIVQHINRALKQTRSDIMKPFDKKSLKYRALKYYWKLIQKDSRKRSL
                     KPFYSRTFRQTLTPRECLNKIFSLVPELKSYYDLYQLLLFHLQEKNAKHFFGLIHDTLP
                     HLNQTFKTALNTFSRYQDYITNAIELPYSNAKLEATNKLIKDIKRNAFGFRNFDNFKKR
                     IFLALNITKEKTTFVSSRA"
     gene            complement(3049..3654)
                     /db_xref="GeneID:83705628"
                     /locus_tag="I2432_RS09075"
                     /old_locus_tag="LJFMMFNO_01814"
     CDS             complement(3049..3654)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705628"
                     /function="Response regulator containing a CheY-like
                     receiver domain and an HTH DNA-binding domain"
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057302.1"
                     /locus_tag="I2432_RS09075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01814"
                     /product="response regulator transcription factor"
                     /protein_id="WP_015057302.1"
                     /transl_table=11
                     /translation="MKILLIDDHKLFAKSIQLLCQQYDEVDVIDTITSNFNDVTIDLSK
                     YNIILLDINLTNISKENGLEIAEELIQSTPNLKVVMLTGYVKSIYEERAKTIGAYGFVD
                     KNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTEREIAILNLSKKGLSIKEIEETLQ
                     ISRRTVFNHLNHIYSKLLVNNKQEAIYKAEQLGYFMDF"
     gene            complement(3635..5197)
                     /db_xref="GeneID:83705629"
                     /locus_tag="I2432_RS09080"
                     /old_locus_tag="LJFMMFNO_01815"
     CDS             complement(3635..5197)
                     /codon_start=1
                     /db_xref="GeneID:83705629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /locus_tag="I2432_RS09080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01815"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_206158738.1"
                     /transl_table=11
                     /translation="MIRIKKITKSKFLGIAIILLQQLIALLILVYNRENLSLLFSEKVA
                     LVMTLIDTAFIWLAAVLRQKQDDIFKRIIFVISLTIWQYLESVLSRGIPLFLSSGLQII
                     LLYCYTVEITDLILYGQKQFKGKLDKCLLIIIFVSTISLLVNRILFNILFLIIFTILHL
                     YPLLVIVLYYRYFRQQISVVKRSLILFSLLLLVILGSQFYGEMLDVNQAFNNLGWYLFP
                     LIMSTIYYFKVIHDKFSSVTQRWLGNYKTRIELLSVLLIVCWVVLIRVLVKDFLLFFIV
                     VDASTLFCLVAISCIFYYLENSKQNFDYKNRRLNYFMKSKENMRVEFSNYLHDDVLQNI
                     IAIKNLLSLENSDITQGFIVNELNDLVSGIRDEIDTYHPIVPVNRTMKENIQSLFDDIV
                     KRRKSNKLLYFNCSNSAIIPPPYGDIVYRFIKELINNAIKYGVSKDIHLSLKVQSDIII
                     IEESNHIVEKVKSINYGRGLKSFQETLAAFDGDMELQIDNKQFNIRILLPIDWKLCYED
                     FIN"
     gene            complement(5236..7143)
                     /db_xref="GeneID:83705630"
                     /locus_tag="I2432_RS09085"
                     /old_locus_tag="LJFMMFNO_01816"
     CDS             complement(5236..7143)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705630"
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561001.1"
                     /locus_tag="I2432_RS09085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01816"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_152652335.1"
                     /transl_table=11
                     /translation="MIWSITKSNIKKNFSLYRIYFLATIGLLSIFIAFLNFISDKIIAE
                     KIGDSGQALVIANGSLVFLTVFLVIFLIYFNNFFVKKRSQELGVLAILGFSKRELTKLL
                     TLENLVILVLSYLVSLLLGPTLYFLAVLVITHLLNLTMEVQWFITVNEIIESLGILVVV
                     FLINFITNGLIISKQSLIEFVNFSRKAEKKIRIRKVRAIIAITALLLSYVLCLATVFSS
                     TRNMLLSIGMGPISLLIIILIIFGTIFTVRYGLTFVISLLKENKKRLYRPLSNIIYPKF
                     NYRIATKNKLLTVLGGLLTLTVSVTGIMVMLYAYSLNGIERLTPSAIEYNVESENGQVN
                     VTNILENNQVSLVDVDLLRLNTTPEVTITESGQTIPYFDIINYSDYKELMKAQGRTNSI
                     EGSESLPLLINYYPTEISLGKTFNLENVYDVTVKQVSTNNVFSFSTSVTTLVVSDKLYA
                     ELSSRFPEKEMTIRTFNGNSIRSNETFYNQFSAVPDVISSYSREYTVKTANIATYIFIT
                     FLSILFIICTGSILYFTSLIEIMENKEEYGYLSKLGYSKKLINRILGYETGILFLIPVL
                     IGIVNGSMLLSFYKYLFMDTLVAGNIIMLSLLLCLFFFLIIYGTFYLLTLRSVKSIINN
                     "
     gene            complement(7145..7882)
                     /db_xref="GeneID:83705631"
                     /locus_tag="I2432_RS09090"
                     /old_locus_tag="LJFMMFNO_01817"
     CDS             complement(7145..7882)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705631"
                     /function="'ABC-type sugar transport systems, ATPase
                     components'"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000812013.1"
                     /locus_tag="I2432_RS09090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01817"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015057298.1"
                     /transl_table=11
                     /translation="MNQLILKDVCKRYPNQPNYALDHINLTVGKGEFVAVMGRSGSGKT
                     TLLNVTSIIDKIDSGSIYCADKEISAFSNNEATNFRKNDIGFVFQDYMLLDSLTIRENI
                     SVALSLKNIDSSKIDDLINNYAKRFNLYEQLNKYPYQLSGGQRQRVSIIRAIIKEPEII
                     FADEPTGALDLKSSERTMRILNEINKTEKVTILMVTHDVLSASYADRVVLLKDGKLHME
                     IDKEVCGESFYDVISQALSDRGE"
     gene            complement(7879..10023)
                     /db_xref="GeneID:83705632"
                     /locus_tag="I2432_RS09095"
                     /old_locus_tag="LJFMMFNO_01818"
     CDS             complement(7879..10023)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705632"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887183.1"
                     /locus_tag="I2432_RS09095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01818"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_206158739.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.5e-21, bitscore:
                     72.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKITPIEQTTPTECGLCCLYMMLDYFDIPETYFKLKQQVNLGRN
                     GLSIKNISDIASIYGVTCKTYRFAQCPETLPVMVFVSDSHFVILEDIREDVFTIVDPAV
                     GKYVLAKNEFFELSPKFYTEFFYDRTTNSSKQIVKRGLVGKNVKKMIFINRKDIFLTIL
                     YTLIFQIITVSIPFFIRGIIDGDWGFLKKFSYLESAILLSIIIFFQGGFYFLKNISLVK
                     LQNKFHSAISEKFVTKLLKLPIEYIGKIDKTDIIHRYNCLMIVRELLSERIMSIWLDII
                     LMFASISYITYISKPLGIILGIVFIVEMMIFFLSLSIKQEKLGKEVLRQKNSLQTFFSL
                     MDGLFLFKAKNSEKELLSKWDKSFKDYINSAYDRNRYFSLLGAVNYVITFSVPILLILL
                     FLYYSPNSSSGELILLYMMVLNFINPINNILNSIDEILYGVKHYERVLEISTLDDETNS
                     TYKLSEDTDIEINLKNINYRYELNGAEVLNGINLKVHSGEFIAIIGKSGSGKTTLAKML
                     LGYVSPSSGNIIYNNTPYSKIDKKDFREISAFVSQDSPIFDGDVMYNISLGKESISGEQ
                     VIETCRRVSIYDDIMSMPMKFHTPLFRDNPSISGGQKQRISLARELVTTPRILVLDEPT
                     SALDVKTERIIQKNVEALHCTRVLVTHRLNTVEKADKILIMDNGKIIDYGSHHYLYKNN
                     EYYRDLYDSYMNKYQEEVIE"
     gene            complement(10001..12835)
                     /db_xref="GeneID:83705633"
                     /gene="lanM"
                     /locus_tag="I2432_RS09100"
                     /old_locus_tag="LJFMMFNO_01819"
     CDS             complement(10001..12835)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705633"
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057296.1"
                     /locus_tag="I2432_RS09100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01819"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_206158740.1"
                     /sec_met_domain="DUF4135 (E-value: 5.6e-82, bitscore:
                     272.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.5e-77, bitscore:
                     256.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRDELKLEYQQHQFYEYFNSIFDYDILDTSISENIYLLREKTH
                     KLFYSEFENQLFETVMFLSMKTLVLDINNFSKEIENKSKAYEQYIQQIRGENGISHFFD
                     RYPYLLKQINREVGLVVESYSLLFDRFLKDLSEIRSCFNITEPLSNVEFSLGDSHSQKQ
                     TVVKIEFKEKSVYYKPKSYDSYNILLELIRLLKSNNILSFSLPESLVKADYCWQLGVDY
                     INSNNDEVEKIYFKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQRKLNVQN
                     NNFEGITVDTYQRIYETSLSNGLFPVQFEKNSAPNVSGISGKGGKRKKGKYELINKNRG
                     DMKLVKTDYFQEDSYNIPTLNGKVVEPLDYANEIITGFRECYIFLISQRAKIKEILEGF
                     PELKTRAIFRNTSDYGKFLQASTNPKYLFSEKKRNNLFSILYESKHIEQFIIDSEIKDL
                     MNGDIPYFSMDTSGNVYNSLGTLIGNLGDTTTLFDNIATLNDERMEFTCELIEIALKKP
                     IKHWEREDGKSYHFPSISSEQSFSEEILDSIRRIFIDADKNSFSSEEEMTWLNIDITEA
                     EQWVISPQNITLYNGLIGDALCYLYAYQIFGDEQYLVSLNRILKTLETTKDLIETSDMS
                     VFLGKGGLVYLYFSLWKKLKLPQYQKLYLDIIKEFSNQSLEEQNIDYISGLSGLLVVLC
                     NIYNVEQNKTVYYLINRISEFIIDNVKKEDDKVYWVSDFSDSEILNGLSHGQSGIAYAL
                     LLSWKINKNYNYLKIAKSAIDFENTRISDGNWIDFRNKGKRSELGMPEPIYWCHGATGI
                     GLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGNIELFMNLDGSSKND
                     VNIEGIMLNIVRNSQKFGWESGLPQHTRVFNMMVGELGIAYQLLRYISKYEVPSLLLLD
                     VPKGSVGNEEDYPY"
     gene            complement(12919..13074)
                     /db_xref="GeneID:83705634"
                     /locus_tag="I2432_RS09105"
                     /old_locus_tag="LJFMMFNO_01820"
     CDS             complement(12919..13074)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705634"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /locus_tag="I2432_RS09105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01820"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_015057295.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.3e-18, bitscore:
                     63.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 6.1e-06, bitscore:
                     23.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAMKNSKDILNNAIEEVSEKELMEVAGGKKGSGWFATITDDCPN
                     SVFVCC"
     CDS_motif       complement(12988..13074)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIAMKNSKDILNNAIEEVSEKELMEVAGG"
                     /locus_tag="I2432_RS09105_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12919..12987)
                     /prepeptide="core"
                     /locus_tag="I2432_RS09105_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.40"
                     /molecular_weight="2306.6"
                     /monoisotopic_mass="2305.1"
                     /core_sequence="KKGSGWFATITDDCPNSVFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIAMKNSKDILNNAIEEVSEKELMEVAGG"
                     /leader_location="[12987:13074](-)"
                     /alternative_weights="2324.6"
     gene            complement(13426..14001)
                     /db_xref="GeneID:83705635"
                     /locus_tag="I2432_RS09110"
                     /old_locus_tag="LJFMMFNO_01821"
     CDS             complement(13426..14001)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000035412.1"
                     /locus_tag="I2432_RS09110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01821"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_015057294.1"
                     /transl_table=11
                     /translation="MAPLYNYATILRAGELDIKSARLKAGMTQKELGKILGVTKQTIIN
                     YEKGTTEPSWERLEDIAKALKIDVDDLFPYSELGEKKGDLKWAEHLERLANNFQYARMA
                     EEELLLQSLFDYSKFQREVEQKTYTKEQLNQALELESSNTMSDENKIDLIKLKYEKDIQ
                     KKTDNLISLYKDQSDKELDVIRFENTKL"
     gene            14153..14596
                     /db_xref="GeneID:83705636"
                     /locus_tag="I2432_RS09115"
                     /old_locus_tag="LJFMMFNO_01822"
     CDS             14153..14596
                     /codon_start=1
                     /db_xref="GeneID:83705636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057293.1"
                     /locus_tag="I2432_RS09115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01822"
                     /product="hypothetical protein"
                     /protein_id="WP_015057293.1"
                     /transl_table=11
                     /translation="MTQFYDYTQIIELVSGLNSVSTLKKWRLKIEQLTGHTFQEDRIRT
                     GKRSYSKVFLFTADDIEKLQQIADTKGNLGLDKAILKVYAPSRASPLSINQKINRLTFQ
                     LTGLSQRVTDLTQQEQLLAIRIEQLGKQIEDLEKPKKRKLFGK"
     misc_feature    14704..14719
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.96"
                     /tool="antismash"
     misc_feature    14794..14809
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.19"
                     /tool="antismash"
     gene            14878..15300
                     /db_xref="GeneID:83705637"
                     /locus_tag="I2432_RS09120"
                     /old_locus_tag="LJFMMFNO_01823"
     CDS             14878..15300
                     /codon_start=1
                     /db_xref="GeneID:83705637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057292.1"
                     /locus_tag="I2432_RS09120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01823"
                     /product="hypothetical protein"
                     /protein_id="WP_015057292.1"
                     /transl_table=11
                     /translation="MTNLTLTDTTLKLGELNLDKSQFMLPKKVVVLSARMSYKYQEVNG
                     EQVRTDEPSKLVCSVQDADKIKVLKEMNIAIEELKAITLEIHDNLDKITKLAENDGLLD
                     KTVELVNPQVRLMWNMTRSNWSGVKLVANDLKIIGD"
     gene            15303..16331
                     /db_xref="GeneID:83705638"
                     /locus_tag="I2432_RS09125"
                     /old_locus_tag="LJFMMFNO_01824"
     CDS             15303..16331
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003916 - DNA topoisomerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705638"
                     /function="Putative phage replication protein RstA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002888289.1"
                     /locus_tag="I2432_RS09125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01824"
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="WP_015057291.1"
                     /transl_table=11
                     /translation="MDNSVRVDYFAVTVKDVPPEEVLEEILLMPQDQFALNAWGINKYQ
                     RHYACSDIKVYFNQALDKMGVYLELKGQGCRQYEEFMAGNANNWVALVTRLYRYQVNFT
                     RIDIANDIYDNALSVQTLYAYCKRGLCITRAQHMDYHERSILETGERVGETVTIGARGS
                     QQWCVYNKLMEQTGKGKIVDKTSAWVRAELRCWQGKANIIAQQMVLKRPLTAIYFEAIN
                     GHYRFVRPNDRDTNKRRRQPVKWWLDYLQTETKTRLSIERTKPTLRQSEQWTEKQVSKT
                     LAKLYVAKYEATTLEGADQFLQDLLKLGLSKFTNSDEKEIDQYVREHQSSDTWGIQKDD
                     LP"
     gene            16391..16651
                     /db_xref="GeneID:83705639"
                     /locus_tag="I2432_RS09130"
                     /old_locus_tag="LJFMMFNO_01825"
     CDS             16391..16651
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196071.1"
                     /locus_tag="I2432_RS09130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01825"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_015057290.1"
                     /transl_table=11
                     /translation="MQVILPDEQIHQLQLLISQLIENEIKNKLDSNNIESPFLNKQQAC
                     KYLGIANNTLDSWIKKGLPVIRVGKTVRFDRAELNQWLQNQ"
     gene            16722..17939
                     /db_xref="GeneID:83705640"
                     /locus_tag="I2432_RS09135"
                     /old_locus_tag="LJFMMFNO_01826"
     CDS             16722..17939
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705640"
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015647386.1"
                     /locus_tag="I2432_RS09135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01826"
                     /product="site-specific integrase"
                     /protein_id="WP_206158741.1"
                     /transl_table=11
                     /translation="MSITKTKNGTYRLRIYIPEEVKSSLGIDKKVIEKRFKLRSEAKKY
                     ELELQNRIDKILSEDSTSLETNGLILFSDFYHNIWWESYKAGQTTSTTKPPSQATIDGT
                     EIVFRKHILPLLGNYPIDFLNQNKQVVLNLLTQKAEEYANFKVIRSYVNSIFDWAEELE
                     YIETNRLSKTISRIKATKKIKLQEAKNDEDLYLSPSELQAWFTAFEEDLKNDKLLFKDY
                     VLFYTTFFLGDRKSESYALQWKHINTKKQEIQLVQALDKYKNPKSTKGNKKTTFQIPIE
                     LANLLQYWKKQQKAELAKFDIIQSDEQYVFTYIDMKGNVNSPLHADYLNNKMKSVKRRH
                     KELKHATPHKLRHTGATLAKQAGTSLEAISEALTHSDTLTTKTYVNTSNVVPMAVGEIA
                     YRNLKK"
     CDS             17955..18017
                     /gene="allorf_1922024_1922086"
                     /locus_tag="allorf_1922024_1922086"
                     /protein_id="allorf_1922024_1922086"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKSGVNFAKKSSKNTPWCEP"
     CDS_motif       17955..17978
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKSGVNFA"
                     /locus_tag="allorf_1922024_1922086_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       17979..18017
                     /prepeptide="core"
                     /locus_tag="allorf_1922024_1922086_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="1350.5"
                     /monoisotopic_mass="1349.7"
                     /core_sequence="KKSSKNTPWCEP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSGVNFA"
                     /leader_location="[17954:17978](+)"
                     /alternative_weights="1368.6"
                     /alternative_weights="1386.6"
     misc_feature    complement(17988..17997)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            18324..18545
                     /db_xref="GeneID:83705641"
                     /locus_tag="I2432_RS09140"
                     /old_locus_tag="LJFMMFNO_01827"
     CDS             18324..18545
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001100856.1"
                     /locus_tag="I2432_RS09140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01827"
                     /product="AbrB/MazE/SpoVT family DNA-binding
                     domain-containing protein"
                     /protein_id="WP_024379186.1"
                     /transl_table=11
                     /translation="MNVILRKTGNSTVITIPNKIKETLGVEIGEEIEFVTSGNNVIIRK
                     AEPKFDFDKELEKAMNQYDELLKELVDR"
     gene            18542..18949
                     /db_xref="GeneID:83705642"
                     /locus_tag="I2432_RS09145"
                     /old_locus_tag="LJFMMFNO_01828"
     CDS             18542..18949
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83705642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269840.1"
                     /locus_tag="I2432_RS09145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01828"
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /protein_id="WP_043026593.1"
                     /transl_table=11
                     /translation="MRYLTAEDIIKINVMVIGKYSPNEPVGIADPNSLRMIVEQPKQEI
                     FGKVLYPDIYSKAAIIWINLIKKHPFYNANKRTAVLALHMFLAMNGYQSNLSLQDGLEK
                     TVEIATFQGDFEDLKKTIIQFLKQDGNITKL"
     gene            complement(19315..20748)
                     /db_xref="GeneID:83705643"
                     /locus_tag="I2432_RS09150"
                     /old_locus_tag="LJFMMFNO_01829"
     CDS             complement(19315..20748)
                     /codon_start=1
                     /db_xref="GeneID:83705643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082309.1"
                     /locus_tag="I2432_RS09150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_01829"
                     /product="ATP-binding protein"
                     /protein_id="WP_111678597.1"
                     /transl_table=11
                     /translation="MNRTLHYYQFSPETQYLDRKSARKKPQELLKHLIAFANADGGQLV
                     VGIEDEKQDNIITGFKDGRAYPIDDFKKIDREMRDTPLDLSFEEIPVVNHKGEDDLILV
                     ISVELSSNRVIAAPNDEVYLRQGDESVKLSYEQRTQLSYDKGQRFFEDEVVPDATLEDI
                     DDNLVQDFKNRFDISERSTEEILKARRFLVNGKLTKAAILLFGKCPSAFFPQARVRFQR
                     FDGTDMGTGSSFNVIKEVTFDDALPVLIIKVRDFIRTQLREFQYLDDNGQFQILPEYPE
                     FAWFEGVVNAVTHRDYSVYGDHIRVLMFDDRLEIHSPGKLPNIVTVDNIKHERFSRNPR
                     IARTLTEFGWVREMNEGVKRIYSEMESAFLHEPKYSEPGNKVVLILENNIVSRHLRTRD
                     SLEKQFSDFGTLNADEQAIIHFMYNSGEKMTTAKAIELTGRSRSFVVKMLHHLRDLEII
                     TWFGSSKNDRNQYYLLVDK"
     misc_feature    complement(21189..21202)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.15"
                     /tool="antismash"
     misc_feature    22436..22450
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 20.1"
                     /tool="antismash"
     misc_feature    22491..22505
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.04"
                     /tool="antismash"
ORIGIN
        1 atctgcctgg cctatgaaca tctgccagac tagataagta gtagccaagc tttaataaag
       61 taacaagacc ttgatttttt tgaattgcac cccaacagtt agccaaaaac tctaacaggc
      121 tggggtcagt tcattcatca aggtcttttc ttctttttat ctataggcgt tacaaaaagg
      181 acatgaaacg acaagccttt ggacttaact ttaaaaactt caaaaccaag agccccaatg
      241 ctttgaacat cacaaaagag aaaataaaaa tgatctcctc tcgtgcttag ctataagtca
      301 ctcactacag ttgacaaaga gacaaaaaac acccaagata aaactcttga gtgctctgaa
      361 acgttgatat aactgaatat taacgttttg aggcacagag actacgtctc ctttgcagcc
      421 gtattcgtaa gcgactaaag ccgcaacgac tacgtcaatt gcgtcgccag ttctttcaaa
      481 aaagaaaata ctccatggta atccatgaag tattgttctg ctgtatcgta gctggttctt
      541 aacgttttga gaactggcta gctttacgag ctttcttaag acctggtttg aacaactttt
      601 gtttgactaa atttcaaaag cctttaatat caaacatttc cacgattttt tgaaaacact
      661 atttcaatct atttcaacta atttcgtctg aatggtgtga attttaccct aaaatcattg
      721 aattgagcta aattatactc aaaagttcac accattgtaa gatgttctta attgcacaaa
      781 tgaacaatat atgctatcat gaaaatataa tgaaataccc aagatttgaa ttttacacac
      841 gtccaaatgg acggactgag tttatcgaat ttttacaaag tataccgaca aaggacaagc
      901 agaaactcct tgctactatt agtgtaatcc aagagcaagg cttactggtg gctcaacgta
      961 tggagtgggt taaaaagtta gatagtgata tttttgaaat tcgttctaag gtatcaagta
     1021 atattcagcg tgccctttat tttcatgttg ttgatgaccg ctttatcatt acgcatggat
     1081 ttactaagaa aacgcaaaag acccctacta ctgaaatcca ccacgctaaa gctctgaaaa
     1141 aagaatttga ggagaattat aacaatgaca accattaaat ttgacgattt tttgaatgaa
     1201 gaattgaaaa acaatgactt caaatttggc tatctggctg aaaaagctat cttagaaagc
     1261 gccattgctg tctataatgc acgccaaaag gcggggctta gccaacgtga actcgctgac
     1321 ctctcacatg ttccacaatc caccatcgca cgtattgagc gcggcaacaa tacgagtatc
     1381 gaaaccatga gcaaaatcgc atttgctctt aataaacatc ttactattca cattggttaa
     1441 tgtttatttt tatagtttaa aggctctata atttctgtag tgggtaactc cactgtggag
     1501 attatagggc tttttgagta ccaaaaagtc ccataagact tataatgaaa agcgactaaa
     1561 caactcatta gaaagtatct tatggaacac ctcaataata ccacattact tatcggaatc
     1621 aaagacaaac atatcacctt gactaaagct atccaacatg atactcatat caaagttatc
     1681 gctacactag actataaccc tcctaaatgt aagcactgta ggggtaaaca aattaagtat
     1741 gacttccaga agccctctaa aattcccttt atcgaaattg gaggctttcc tagtctcatt
     1801 cgtttgaaaa aaagaaggtt tcaatgcaaa tcctgtcgaa aagtcactgt atctgaaact
     1861 accctggtta agaaaaattg ccaaatttct gagatggtga gacagaaaat cgctcagctt
     1921 ttactcaaca gagaggctct cacccatatc gcttctaagc tcgctatctc cacttctacc
     1981 gtctatcgca agcttaagca gtatcatttc cgagaggatt acgccaattt gccagaagtt
     2041 ctctcttggg atgagttctc ttatcagaaa ggcaaattag ccttcattgc tcaggatttt
     2101 aacactaaga aaatcattac cattcttgat aatagacgtc aaacaaccat ccgaaatcat
     2161 ttctttaagt actctaaaga ggctagaaac aaggtgaaag tcgttactgt cgatatgtct
     2221 ggaagttata ttcctctcat taaaattcta tttcctaagg ctaaaatcgt tctcgatcgt
     2281 tttcacattg tccagcacat caatagagct ctcaagcaaa cacgtagtga catcatgaaa
     2341 ccatttgaca agaagtctct taaatataga gctcttaagt actactggaa gcttattcaa
     2401 aaggatagca gaaaacggtc tcttaagcct ttctattctc gcaccttcag acaaacctta
     2461 actcctagag aatgtctcaa taagatcttc tcactagtgc ctgagttaaa atcttattat
     2521 gacctgtacc agctgctcct ttttcacctg caagaaaaga atgccaagca tttctttggt
     2581 ttaattcatg acacactacc acatcttaat cagactttta aaacagctct aaataccttt
     2641 agtcgctacc aagactacat caccaatgcc attgaactgc cttattctaa cgctaagtta
     2701 gaagccacta acaaacttat caaagatatc aagcgcaatg cgttcggatt tcggaacttt
     2761 gacaacttta aaaaacgcat cttcctcgct ttgaacatca caaaagagaa gacaaccttc
     2821 gtctcctctc gtgcttagtt atcagtcacc cactacagtt gacatggagc caaatatcca
     2881 gctaaaaagc cctatcaggg gctttttatt gcatattaaa aaaataatca ttggtttaat
     2941 atcgttattt atcacggcta cttttttata aagaattact tactttttat ttcacagaac
     3001 ccctaacaaa tgtggagata gagcttaatt aagttgtttg cctacaactc agaaatccat
     3061 aaaataccct aattgctcag ctttgtagat agcctcttgc ttattattta ccaagagctt
     3121 tgaatagatg tggttcaaat gattaaatac cgttctccta ctaatttgta atgtttcctc
     3181 tatctctttt atagagagac ctttcttact caaatttaag atagctattt ctcgttcagt
     3241 taaagattca acataatcct gagactcaat ttgttcaaaa tactttttcc cagaatccac
     3301 tttttttaag atagaaatga gttgtttagg gtctatattt ttatctacaa aaccatatgc
     3361 gcctattgtt tttgctctct cttcatagat tgatttaaca tatcctgtca gcataacaac
     3421 tttcaaatta ggagtagact gtatgagttc ctctgctatc tccaatccat tctctttaga
     3481 aatatttgtt aaattaatat caagtaatat aatattgtac ttagacaaat caatcgtcac
     3541 atcgttaaaa ttagaagtaa tcgtatctat gacatctact tcatcatact gttgacataa
     3601 cagttggata ctctttgcaa atagtttatg gtcatcaatt aataaaatct tcatagcaca
     3661 gtttccaatc tatgggaagt aatattctga tattaaattg tttattatct atttgtagct
     3721 ccatatcccc atcaaaagct gctagtgttt cttgaaatga tttcaaacct ctaccataat
     3781 ttatagattt aactttttcc actatatgat tgctctcctc aatgataata atatcagatt
     3841 gaacctttaa agataaatga atatctttac taactccata ttttatagca ttattaatta
     3901 actcttttat aaacctgtaa acaatatctc catatggagg tgggattatt gcactattcg
     3961 aacagttgaa atacaataat ttattacttt tccttctttt gacaatatcg tcaaaaagag
     4021 actgtatatt ttctttcatt gttcgattaa caggaactat tgggtggtaa gtatcaattt
     4081 catccctgat accagaaact aaatcattta actcattaac aatgaaaccc tgtgttatat
     4141 cactattttc tagcgagagt aagtttttta tcgctatgat attttgcaag acatcatcat
     4201 gcaaataatt tgaaaactcc actctcatgt tttcttttga tttcataaaa tagttcagcc
     4261 ttctattttt atagtcaaaa ttttgtttag agttttctaa ataataaaat atacaagaaa
     4321 ttgccactaa acaaaacaac gtacttgcgt caacaactat aaaaaatagt aaaaaatctt
     4381 taactagtac ccttataagt acaacccaac aaacaataag aagtacagat aatagttcta
     4441 tacgagtttt gtagttacct aaccatcttt gagtaactga actaaactta tcatgtatga
     4501 ccttaaaata gtatattgta ctcataataa ggggaaacag ataccacccc aaattattaa
     4561 aggcttgatt aacatctagc atttctccat aaaattgact accaagtatt accagcaaaa
     4621 gcaaagaaaa cagtatcaat gaacgtttta ctactgatat ttgttgccta aaatacctat
     4681 aatatagcac tataaccaat aacggataaa gatgtaaaat agtaaaaata atcaagaata
     4741 aaatattaaa taaaattcta ttaactaata ggctaattgt agaaacaaaa ataattatta
     4801 acaagcactt atctagctta cccttaaatt gtttctgccc atataatatt aaatcagtaa
     4861 tctcaacggt ataacaatag agcaatataa tttgcagacc actactcaaa aagagaggaa
     4921 ttccccttga tagcacagat tccaagtatt gccaaattgt taaagagatg acaaaaataa
     4981 ttcttttaaa aatatcatct tgtttttggc gtaatactgc tgctagccaa ataaaagctg
     5041 tatcaataag agtcattaca agagctactt tttcagagaa aagaagagac aagttctctc
     5101 gattatagac taaaatcaac aaggctatta attgttgtaa caagattatt gcaatcccca
     5161 aaaatttact ctttgttatt ttttttattc ttatcatatt actacttaat tattaaagtt
     5221 aagaggtttt tagaattaat tgttgattat tgacttcact gaccgcaatg tcaataaata
     5281 aaatgtgcca tatattatca agaagaaaaa cagacaaagc aataaagata gcattatgat
     5341 attgcctgct accaacgtat ccataaataa atatttatag aaactaagca acatactacc
     5401 atttacaatt ccaattaata caggaataag aaaaagtata cctgtttcat atccgagaat
     5461 ccgattaatt aattttttac tataacctag cttacttaga tagccatatt cttctttatt
     5521 ttccatgatt tctatgagac ttgtaaagta tagaatacta cctgtacaaa taataaagag
     5581 tatggatagg aaagttataa agatataagt cgcaatatta gcagtcttta ctgtgtattc
     5641 cctactataa ctactgataa catcaggaac cgcactaaac tgattgtaaa atgtttcgtt
     5701 tgacctaata gaatttccat taaaagtcct aattgtcatt tctttctctg gaaaacgaga
     5761 actaagttca gcatataatt tatcagaaac aaccagagtc gtgacacttg tagaaaaact
     5821 aaaaacatta ttcgttgata cttgttttac agtaacatca tatacatttt ccaaattaaa
     5881 ggttttcccg aggctaattt ctgttggata ataatttatt aacaatggta atgactcact
     5941 accttcaata gaatttgttc tcccttgagc tttcattaac tctttataat cactgtaatt
     6001 aattatatca aaataaggaa ttgtttgccc agattctgtg atagtcactt ctggggtagt
     6061 gttcaatctc aataggtcaa catcaactag gctcacttgg ttgttctcta aaatatttgt
     6121 aacattaact tgaccatttt ctgactcaac attatattct atagcagatg gagtcaatct
     6181 ctctattcca ttaagagaat aagcatagag cattaccata attccagtaa ctgaaacggt
     6241 taatgttaaa aggcctccca agactgttaa taatttattt tttgtcgcaa tacgatagtt
     6301 aaatttggga tagatgatat tagatagagg acggtataac ctttttttat tttcttttaa
     6361 caaagaaatt acaaaagtca atccatatct gactgtaaaa attgttccaa aaataattaa
     6421 gataattatc aatagagaaa tcggtcccat ccctatgctt aatagcatat ttcgtgtgga
     6481 tgaaaatact gtcgccaaac ataaaacata tgacaatagc aatgcagtaa tagcgataat
     6541 agctctgact tttcttatcc tgattttttt ctcagccttt cttgagaaat taacaaattc
     6601 aatcaaagac tgtttactaa tgataagtcc atttgtgatg aaattaatca gaaaaactac
     6661 aactaatatt cctaaagact ctataatctc attaactgta ataaaccact gaacttccat
     6721 tgttaaattc aatagatgag taattaccag tacagctaaa aaatataaag tcggtcccag
     6781 caataaactt accaagtaac tcaaaactag aataacaaga ttttctaaag tcagtaattt
     6841 tgttaattct ctttttgaaa accctagtat tgctaagact ccaagttctt gactacgttt
     6901 tttaacaaag aaattattga aataaattaa aaatatcacc aaaaatacag tcaaaaaaac
     6961 taatgacccg ttagcgataa ctagagcttg gccactatcc ccaatttttt ccgcaatgat
     7021 tttatctgag ataaaattta gaaaagctat aaaaatactt aataaaccaa tcgtagctag
     7081 aaaatagata cgatataacg aaaaattttt tttaatgtta gattttgtaa ttgaccaaat
     7141 catattactc acctctatcg gataaggctt gactaattac atcgtaaaac gactctccac
     7201 aaacctcttt atcaatctcc atgtgaagtt taccatcttt gaggagtaca actctatcgg
     7261 cataagaagc tgataaaacg tcatgagtaa ccattaaaat agttaccttt tccgttttat
     7321 tgatttcatt caaaatcctc attgttcttt cagaagattt caagtcaagt gctccagttg
     7381 gttcgtcagc aaaaataatc tctggttctt taatgattgc tctgataata ctaaccctct
     7441 gtctctgacc tccagaaagt tgataaggat atttattcaa ctgctcatat aaattaaatc
     7501 tttttgcata gttatttatc aaatcatcaa tctttgatga atcaatattt tttaaagata
     7561 aagcaacaga aatattctcc ctaatggtta gactgtctaa cagcatataa tcttgaaaaa
     7621 caaaaccaat atcgtttttt ctaaaattag ttgcctcgtt attagaaaat gcactaattt
     7681 ctttatctgc acaataaata ctcccactat caattttatc aataatcgaa gtaacattta
     7741 agagtgtcgt tttaccacta ccgctacgtc ccatgacagc cacaaattct ccttttccca
     7801 cagtcaaatt gatatggtct aaagcataat tcggttggtt tggatatctt ttgcaaacat
     7861 cttttaatat taattgattc attctattac ttcctcctga tatttattca tgtacgagtc
     7921 atataaatca cgataatact cattattttt atataaataa tgatgactac catagtcaat
     7981 aattttccca ttatccatta ttaaaatctt atcagctttt tcaactgtat taagtctatg
     8041 ggtaaccaaa accctagtac aatgtaaagc ctcaacattt ttttggatta ttctttcagt
     8101 ttttacatct aaagctgatg taggttcatc aagaactaag attctagggg tagttactaa
     8161 ctctcttgct agagaaattc gttgtttttg cccaccagat attgatggat tgtctcgaaa
     8221 aagtggggta tgaaacttca ttggcatact cataatatca tcatatattg atactcttct
     8281 acaagtttca attacctgct ctcctgaaat agattcttta ccaagcgaaa tattatacat
     8341 cacatcccca tcgaatatgg gagaatcttg agaaacaaaa gccgatatct ccctaaaatc
     8401 ttttttatca attttggaat aaggagtatt attgtatatg atgtttccac tactaggact
     8461 gacatatcct agtagcatct tagctagagt agtcttccca cttccacttt ttcctataat
     8521 tgcaataaat tctcctgagt gaacttttag gttaatccca ttcagtacct ctgctccatt
     8581 taactcatat cgatagttta tattttttaa atttatttct atatccgtat cctctgataa
     8641 tttataagtg ctatttgtct catcatcaag agtcgatatc tccagtaccc tttcgtaatg
     8701 cttaacacca tatagaatct catcaatcga attcaaaata ttattaatgg ggttaataaa
     8761 attcaaaacc atcatataaa ggagaataag ctcaccactg ctactatttg gcgagtaata
     8821 taaaaacaac aaaattaaca aaatgggtac ggaaaaagta atcacataat ttaccgcccc
     8881 taaaagactg aagtacctat ttctgtcata tgctgaattg atatagtcct taaaactttt
     8941 atcccatttt gacaaaagtt ctttttcaga attcttagct ttaaaaagaa atagcccatc
     9001 catcagtgaa aagaatgttt gtaaagagtt cttttgtctt aaaacttctt tccctaactt
     9061 ttcttgttta atgcttagtg aaaggaaaaa aatcatcatt tccacaataa aaactatgcc
     9121 caatataatt cccaaaggtt tagaaatata tgtgatataa ctaatactcg caaacattaa
     9181 gataatatcc aaccagatag acataattct ttctgacagt aactccctca caatcatcaa
     9241 acaattatat ctatgaatga tatctgtttt atcaattttt ccaatatatt ctatgggaag
     9301 tttcaataac ttagtcacaa acttttctga aatagcgctg tgaaatttat tttgcaattt
     9361 cactaaagag atattcttta gaaaatagaa tcctccctga aaaaaaatta ttatagaaag
     9421 taggattgca ctttctaaat agctaaattt tttaaggaaa ccccaatctc catcaataat
     9481 accccttata aaaaacggaa ttgacactgt aataatctga aaaatcagag tatatagaat
     9541 agttaaaaaa atatccttcc tatttataaa tatcattttc tttacgtttt tgccaactaa
     9601 tcctcgtttg actatttgtt ttgaagaatt agtcgtccta tcataaaaaa actcagtata
     9661 aaatttagga gataattcaa agaattcatt tttagctaag acatatttcc caacagcagg
     9721 gtcaacaata gtaaagacat cctcacgaat atcctctaaa attacaaagt gtgaatctga
     9781 aacaaatacc atgacaggca atgtttctgg gcactgggca aaacgataag ttttacaagt
     9841 aactccgtag atagaagcaa tatctgagat attctttata ctcaatccat ttcttcctaa
     9901 attgacctgt tgtttcaatt taaagtatgt ttctggaata tcaaaataat ctaacatcat
     9961 atacaaacaa cataatccac attcagtagg agttgtttgt tcaatagggg taatcttctt
    10021 catttccaac acttcctttt ggaacatcta ataacaataa tgatggtact tcatacttag
    10081 atatatatct aagtaactga tatgctatcc ctaattctcc aaccatcata ttgaatactc
    10141 ttgtatgctg tggcaagcca gattcccaac cgaatttttg agaattacga acaatattaa
    10201 gcatgatacc ttctatattt acatcatttt tcgaggagcc atctaaattc ataaataatt
    10261 ctatattgcc cattttcccg tgacaaaggc aatccgaatt caaataacca ttatttaata
    10321 ccgtttgttt agccatttca taattatttt tcaactcttt atcgtttaac cattttgatt
    10381 ctctatatct cgttaatccg atacctgttg caccatgaca ccaataaata ggttctggca
    10441 ttcctaactc tgaacgtttt cctttatttc taaaatcaat ccaatttcca tcggaaatac
    10501 gagtattttc aaaatcaata gctgacttcg ctattttcaa ataattataa tttttattga
    10561 ttttccatga taaaagtaat gcatatgcaa ttccagattg cccgtgagac agtccattta
    10621 gaatttctga atctgaaaag tccgataccc aataaacttt atcatcttct tttttcacat
    10681 tatcaataat aaattcagat atccgattaa ttaaataata tactgtttta ttttgctcca
    10741 cattatatat attgcataaa acaactaata gaccagacaa tccagaaata taatctatat
    10801 tttgctcctc tagtgattgg ttggaaaatt ctttaattat gtctaaatat aatttttggt
    10861 attgaggtaa tttaagtttt ttccacaaac taaagtatag ataaaccaaa cctccttttc
    10921 ccaaaaatac tgacatatca ctagtttcta taaggtcctt cgtggtctcc agtgttttca
    10981 atatcctatt taatgatact agatattgct catcaccaaa aatttgataa gcatataaat
    11041 aacatagagc atctccaatt aatccattat acaaggtaat gttctgagga gatattaccc
    11101 attgctcagc ctctgtaata tcaatattga gccatgtcat ctcctcctct gaagaaaaac
    11161 tattcttatc tgcatcaata aatatccgtc taatactgtc taatatttcc tcactaaaac
    11221 tttgttctga ggatattgat ggaaaatgat aagatttccc atcctccctc tcccaatgct
    11281 taatcggttt ttttaaggct atttcaatca attcacaagt gaactccatt ctttcatcgt
    11341 tcaatgtcgc tatattatca aataacgtgg ttgtatctcc tagatttcca attaatgtcc
    11401 ctaaagaatt atatacattt ccactggtat ccattgaaaa gtaaggaata tcaccattca
    11461 tcaaatcttt aatttcacta tcaataataa attgttcaat atgttttgac tcatatagta
    11521 tcgaaaataa attatttctc tttttttctg agaaaagata ctttggattc gtagaggctt
    11581 gcaaaaattt tccatagtcg gaagtatttc tgaatatagc tctagttttc aattctggga
    11641 aaccttctaa aatctcttta atctttgcac gttgcgatat aagaaatata tagcactctc
    11701 taaaacctgt aattatctca ttagcatagt cgagaggttc caccactttc ccatttaatg
    11761 tcggaatatt ataactatct tcctgaaaat agtcagtttt cactaacttc atatctccac
    11821 gatttttatt tatcagttca tactttccct tttttctttt cccacctttt ccacttatcc
    11881 cagaaacgtt aggagcgctg tttttctcaa attgtacggg aaataaacca tttgaaagtg
    11941 atgtctcata aattctctga taggtatcaa cagtaatccc ttcaaaatta ttattttgta
    12001 cattcaactt tctttgaaaa aatgtttcaa catcaattaa atataaatct ccgcctgaaa
    12061 caatcacatt ttccatatgt aagtccgtaa tggaaaaaat ttcagaaaat gcagctaaaa
    12121 caccatactt aaagtaaatt ttctctactt catcattatt agaatttata taatccacac
    12181 caagttgcca acaataatct gctttaacta agctttcagg aagactgaac gagagtatat
    12241 tattagattt cagtaaacga ataagttcta acaagatatt gtatgaatca taacttttag
    12301 gcttgtagta aacagatttt tctttaaatt caattttaac gactgtttgt ttttgggaat
    12361 gactgtctcc aagtgaaaat tcaacattac ttaggggctc agtaatatta aagcacgacc
    12421 ttatttcaga caaatctttt aaaaacctat caaatagcaa agagtacgat tccactacca
    12481 atccaacttc tctattgatt tgttttagca aatatggata tctgtcaaaa aaatgactta
    12541 tcccattttc tccccttatc tgctgtatat attgttcata tgcctttgac ttattttcaa
    12601 tttccttgga aaaattattt atatctagaa ctagtgtttt cattgaaaga aacattacag
    12661 tttcaaataa ctgattttca aactcactat aaaataactt atgtgtcttt tcccttaaca
    12721 aataaatatt ttcactaata gaagtatcta atatgtcgta atcaaaaatt gagttaaagt
    12781 attcgtaaaa ctgatgttgc tgatattcta actttaattc atctcttttt atcatattta
    12841 tcctaccatt gctcaaaaat cctgcctaga ctaagtctaa acaggaaatt tttagtctgc
    12901 ttatccagat tgttttaatt aacaacaaac aaatactgag ttcggacagt catcagtgat
    12961 agttgcaaac caacctgaac cttttttacc accagctact tccataagtt ctttttcaga
    13021 aacttcttcg atagcattat tcaaaatatc ttttgagttt ttcatggcaa tcattctccc
    13081 tcctattagt atgtagtaga taatttctac actcttattg taaccaatat atcttcattt
    13141 ttaatgagta aaaagtgcaa aaattgtttt tttaatattt ttgagttgta aaataagagg
    13201 tcactttata acaagtaatc ctctcatata ataaaataaa tctcgttctt tacagctatt
    13261 ttataatcca atcacttctc attataaaat taattcctta tcggaaatag tttactttat
    13321 ttgcttaatt atgtaatgag tatttagcgc aaaaaccaat gttaaatatg tttgaaaagg
    13381 aatcaaaaaa gtcttggcaa aaattgctaa gactcaaata actatttata gctttgtatt
    13441 ttcaaatcga attacatcaa gttccttgtc tgattggtct ttatacaacg agatgagatt
    13501 gtcggttttc ttctgaatat ctttttcata tttaagtttg atgaggtcta ttttattctc
    13561 atcagacatg gtattgctgc tttccaattc caacgcttga ttgagttgct ctttcgtata
    13621 agttttttgt tccacttctc gttgaaattt tgagtaatca aaaagacttt gtaacagcaa
    13681 ttcttcttct gccatacgag catactgaaa gttatttgcc aaacgttcca aatgctctgc
    13741 ccattttaaa tctcccttct tttccccaag ttcactatag ggaaaaagat catcaacatc
    13801 aattttcaag gcttttgcta tatcttcaag gcgctcccaa cttggttctg tagtgccttt
    13861 ttcgtagtta ataattgtct gtttagttac accgagaatt tttcctaatt ctttttgggt
    13921 cattcctgct tttaagcgag ccgacttaat atccaattct ccagctcgta aaatagttgc
    13981 ataattatat aaaggagcca ttagtatctc actttctagg taaaatattt ttttactttt
    14041 tgttgacaag taaattttta ttttgtataa taaagataat tcaaggtaaa ataactattt
    14101 acctcttgat tatacaatat tttaccttaa aagtaaatga gaggagacaa aaatgacaca
    14161 attttatgat tatactcaaa taattgagct tgtctctggt ttgaactctg tctcaacctt
    14221 aaagaaatgg cgtttaaaga ttgaacagtt aacaggacac acctttcaag aagataggat
    14281 acgaacagga aaacgttctt atagcaaagt cttcctcttt acagctgatg atattgaaaa
    14341 gctccaacaa attgcagata ccaaaggaaa tcttggacta gataaggcaa tcctaaaagt
    14401 ttatgctccg agcagggctt cccctttatc tattaaccaa aaaattaatc gcttaacgtt
    14461 tcaactaacg ggattaagtc aaagagtaac cgacttaaca caacaggaac agctattagc
    14521 tattcgtata gagcagttag gcaaacagat tgaagattta gagaaaccaa agaagagaaa
    14581 attatttggc aagtgagtac ggttagaagc acaacgccat gggcgaatgt gtggaaacac
    14641 ggtagcccat aaatggcgtg cccgtgcttg gacgggcgaa cttcccccta aattagtacc
    14701 ccattactaa tagggggtac gaacgtacac gaaagtaggg ctaaaccctt gatacgtctg
    14761 gggttaaagc caatcagttg aagttttcgc tgaaatccct tggggagtaa ggttcaaagc
    14821 taattctgcg tacgtttaga aaagataact actttagaaa atacaaagga gaatactatg
    14881 acaaacttaa cactaactga cacaacactt aaacttggcg aattgaacct tgataaaagt
    14941 caattcatgc tacctaaaaa agtggtggtg ctttctgctc gtatgagtta taagtatcaa
    15001 gaggtaaatg gcgaacaagt ccgaacagac gaaccatcca aactagtttg tagcgttcaa
    15061 gatgcggata aaatcaaagt gttaaaagaa atgaacattg ccattgaaga actcaaagcg
    15121 attacgcttg aaattcatga caacctcgac aaaatcacga aattggcaga aaatgacggt
    15181 ttacttgata agaccgttga actcgtcaat cctcaagtcc gtctcatgtg gaacatgact
    15241 cgtagtaact ggtctggagt aaaactagtg gcaaacgacc ttaaaatcat tggtgattaa
    15301 acatggacaa cagtgtgagg gttgactact tcgctgtaac cgttaaagat gttccaccag
    15361 aggaggtgtt agaagagata ctccttatgc cccaagacca gtttgcactt aatgcttggg
    15421 gaataaataa gtatcaacgc cactatgcct gttcagacat caaagtttac tttaaccaag
    15481 ccttagataa gatgggggtc tatctggaac tcaaaggaca aggctgtcgg caatatgagg
    15541 aatttatggc gggtaacgct aacaactggg tagctctggt cacacgcctt taccgctatc
    15601 aggtcaactt tacccgaatt gatattgcca acgatatcta cgataacgcc ttatcggttc
    15661 aaactctcta tgcttactgt aaacggggct tgtgtatcac cagagcccaa cacatggact
    15721 atcacgagcg ttcaatcctt gaaacggggg aacgggttgg cgagaccgtc accataggcg
    15781 cacgaggaag ccaacaatgg tgtgtttaca acaaactcat ggaacaaaca ggcaaaggta
    15841 agattgttga taagacaagc gcttgggtca gagcggagct ccgttgttgg caaggcaaag
    15901 ccaatattat cgcccagcaa atggttctta aaagacctct gacagctatt tactttgaag
    15961 ctatcaatgg acactaccgc tttgtcagac ctaatgacag ggataccaac aaacgcagac
    16021 gtcaacctgt taaatggtgg ctggactacc tccagacgga aaccaaaaca cggttaagta
    16081 ttgaacgcac caagccaaca cttagacaat cggaacaatg gacggagaaa caagtctcaa
    16141 agaccttagc caaactctat gtggctaagt acgaggcaac cacacttgag ggagctgacc
    16201 aatttctcca agacctctta aaattgggat tatcgaaatt taccaacagc gatgaaaagg
    16261 agattgacca atatgtccgt gaacaccaaa gttctgacac ttggggcata caaaaagacg
    16321 acttgccata aacaaatcgc cttagaaata ataactacca atattatatc atgaaaggac
    16381 aaaaaaggct atgcaagtga ttttaccaga cgaacaaatt catcagctac aactgttaat
    16441 tagccagctt atagaaaatg aaataaaaaa taaattggat agtaacaaca ttgaaagtcc
    16501 attcttgaac aagcaacaag cttgtaagta tctaggaatt gccaataata cgcttgattc
    16561 ttggataaaa aaggggttac cagttattcg agttggaaaa actgtccgct ttgatagagc
    16621 cgaactcaat caatggttac aaaatcagta gcattataac cgtggtttga tataattaag
    16681 ccacggtatt tttctagctc aattcaaaaa aggagaatac tatgtcaatt acaaaaacta
    16741 aaaatggaac ttatcgctta cgtatctata tcccagaaga agtcaaatca tcattgggaa
    16801 ttgataaaaa agtgattgaa aaacgtttca aactaaggag tgaggctaaa aaatacgaac
    16861 ttgaattaca aaacaggatt gataaaattt taagcgaaga ttcaacctca ttggaaacaa
    16921 atggtttaat cctcttttcc gatttttatc acaatatttg gtgggaatcc tataaagcag
    16981 gtcaaacaac atctaccaca aaaccacctt cacaagctac tattgacggt actgaaattg
    17041 tctttagaaa acatatcctg cccttgcttg gaaattatcc tattgatttt ctcaatcaaa
    17101 ataaacaggt tgttttgaac ctattgaccc aaaaagcaga agaatatgcc aacttcaaag
    17161 tcatcagaag ttatgttaac tctatttttg attgggctga ggaactggaa tatatcgaaa
    17221 ctaatcgtct ctctaaaacc attagccgta ttaaggcaac taaaaaaatc aaactacaag
    17281 aggctaaaaa tgatgaagat ttatatctat caccatcaga actacaagca tggtttacag
    17341 cttttgaaga agatttaaaa aatgacaaac tcctgttcaa agattatgtg ttattctata
    17401 caactttttt cttaggagat agaaaatctg aaagctacgc tttgcaatgg aaacacatta
    17461 acaccaagaa acaggaaatc caattagtcc aagccttgga taaatataaa aatccaaaat
    17521 ctacaaaagg gaataagaaa acaacctttc aaattccaat tgaattagca aacctgcttc
    17581 aatattggaa aaaacaacag aaagctgagc tggcgaaatt tgacattatc caatctgatg
    17641 aacagtatgt ttttacttat atcgacatga aaggcaacgt gaacagtccc ttacatgctg
    17701 attatctcaa taacaaaatg aagtcagtca aacgccgtca caaggagctg aaacacgcca
    17761 caccgcacaa attacgccat acaggagcaa ctttagctaa acaagcagga acatcacttg
    17821 aagctatttc agaggctcta acgcatagcg acaccctcac taccaaaact tacgttaata
    17881 cttcaaatgt tgtcccaatg gctgttggcg aaatcgccta tcgtaacctt aaaaagtaat
    17941 ggtgtgaatt tggtgtgaaa agtggtgtga attttgctaa aaaatcatca aaaaacaccc
    18001 catggtgtga accatgaagt gctttgaaac gttgatatat ataggtatat taacgttttg
    18061 agaattgtga tgctttacgt gctttcttaa gacctggttt tgggtaacaa aaaccaaatc
    18121 tctgtaaaag actattaaat caagctttca aaagtctttt tcattaaata aacagacttc
    18181 taaatcaatc ctgaaaatca tggattacca atagattacc aaaaatttag ttttcggagc
    18241 ttatgtagtt aagaaacaat gtgtattcac tttacttttt tgtaagttca ttttataatg
    18301 tatatacaaa cggaggtaga accatgaatg ttatcttgag aaaaacagga aatagtactg
    18361 tcattacaat tcccaataaa attaaagaaa ctcttggagt agaaattgga gaagaaattg
    18421 aattcgtcac ttcaggaaat aacgtcatca ttcgtaaagc tgagccaaaa tttgattttg
    18481 ataaggaact agaaaaagcc atgaaccaat acgatgagct tttgaaagaa ttggtggata
    18541 gatgagatat ctaactgctg aagatattat caaaatcaat gtcatggtta ttggcaaata
    18601 ttctcctaat gaacctgttg gcattgctga tccaaacagt cttcgaatga ttgttgaaca
    18661 gcctaaacaa gagattttcg gcaaagttct ctatccagat atctacagta aagctgctat
    18721 tatctggata aatttgatta aaaaacatcc tttttataat gccaataaac gaactgctgt
    18781 tcttgccttg catatgtttc tagcaatgaa tggttaccaa tccaatcttt ccttacagga
    18841 tggacttgaa aagacagttg aaattgctac ctttcaagga gattttgaag atttaaagaa
    18901 aacaattatt caattcctca agcaagatgg aaacataaca aaattataat taaaaagtgg
    18961 ttatcaacct ttcgttgaag accactttta tgttctattg tattctactg tattctactg
    19021 tattctactg tattctactg tattctactg tattctactg tattctactg tattctactg
    19081 tattctactg tattctactg tattctactg tattcttact gtattcccat cactgtattc
    19141 tactgtattc tactgtattc tactgtattc ttattctact gtattctact gtattctact
    19201 gtattctact gtattctact gtattctact gtattctact gtattctact gtattctact
    19261 gtattctact gtattctact gtattcttta ttactaatag tatcctgact gcaatcattt
    19321 atcaactaaa agataatatt gattgcggtc atttttactt gaaccaaacc aagtgatgat
    19381 ttctaaatca cgaagatgat gcaacatttt aacaacaaac gagcgacttc ttcctgttag
    19441 ttcaatcgcc ttcgcggttg tcattttctc tcctgaattg tacatgaagt gaataatagc
    19501 ctgttcatct gcatttagag ttccaaaatc agaaaactgt ttttccaaac tgtctcgtgt
    19561 tcgtagatgt cgactaacaa tgttattttc aaggattaga actaccttat tacctggctc
    19621 tgaatattta ggttcatgaa gaaaagctga ttccatttca gaatagatac gcttaacacc
    19681 ctcgttcatt tcacgaaccc aaccaaattc agtcagggtt ctcgcaatcc gaggatttct
    19741 tgaaaaacgt tcatgcttga tattgtcaac ggtgacgata ttgggtaatt tccctgggct
    19801 gtgaatctct aagcgatcat cgaacatgag tacacgaatg tgatctccat agacagagta
    19861 atcacggtga gttactgcat tgacaacacc ttcaaaccaa gcaaactcag gatattcagg
    19921 caatatttga aattgaccat tatcgtctaa gtactgaaat tcccgcaact gagtacggat
    19981 aaaatctcga acttttataa tcagtactgg caaagcatca tcaaaagtca cttctttgat
    20041 gacattaaag ctactgcctg tccccatatc cgtgccatca aagcgttgaa agcgaacacg
    20101 agcttgtggg aaaaacgctg acggacattt accaaaaagt agaattgctg ccttggtcag
    20161 tttaccattc acgagaaaac gccgtgcttt aagaatttcc tctgtcgaac gttctgaaat
    20221 atcaaaccga tttttgaaat cttgcactaa gttatcatca atgtcttcca gggttgcatc
    20281 aggtactact tcatcttcaa agaaacgttg tcccttatca tagctgagct gagtacgttg
    20341 ctcatagctt aatttaaccg attcatcgcc ctgacgcaga taaacctcat cattaggcgc
    20401 agcaatcact cgattagatg acaattcaac tgagataacc aaaatcaggt catcttcccc
    20461 cttatgatta accacaggga tttcttcaaa agataagtcc agaggagtgt cacgcatctc
    20521 acggtcaatc tttttgaaat cgtctattgg ataagctctg ccatccttga aaccagtgat
    20581 aatgttgtcc tgtttctcat cttcaatacc aaccaccaac tgaccgccgt ccgcattggc
    20641 aaaggcaatc agatgcttga gtaattcctg tggcttcttg cgtgctgatt ttctatccaa
    20701 gtattgagtt tctggtgaaa attggtagta gtgtaaggtt cgattcatgt atttctcctg
    20761 aattctatta actatccgcc cataactcac attgtgtgat aactgttgac aaggcatctt
    20821 caagcccttc tggaggatac ttgtattttc tcaaaagtct cttaacgatc cgtcgcatat
    20881 tagcacgagc agattccttt ttctgccaat caatcgtgcg acttctccgc aattcgtttg
    20941 tcagctcccg cgtcagggca actaactggt cattatcata aaaatcttta acagcagcag
    21001 gtttggtaat cgcatcataa aaagctattt cctctggact aagtcctagt tcatttcctg
    21061 catcacttgc tgcttgcatt tccgacgcca tgcgttttaa ttcttcgata acttcctcat
    21121 ttgtcaacat accatttaag taggctttca tagctctgga aagcatctct gaaaatttct
    21181 cagattgaac aacatttgtt cgcttataaa tatgaacttg ttctcttatc aacctcttca
    21241 acaattcaac cgcaatgttc ctttctttca tctttgcaat ttcgtccaag aatttaggat
    21301 caaacaatga aaaatctctt tcagaatccg caaatagatt gataatacct tcgctcttaa
    21361 tacttgattt tagcaactca ctgattttag cattaatttc tttgaccgat agaggttttc
    21421 gaggattaac aatacgcgtt aatattgttc gaacagcttc aaaataagct gcttcatagc
    21481 gttcctctgg cgttagtaag gaacgacaga gctgcagggc ttgctttaag agagtagcct
    21541 cccgtaaaaa actctcctta tccttgtctc tactagtgat aaagttgaca ccacccgtga
    21601 tgacattagc acgcatcaga ttcgttgcat tttcatcttt aaaagcggtg taatcaaagc
    21661 caaagaacat atcttgacaa acttcaagct tttcttgaaa tttagggtaa gctgtcgcag
    21721 caatattggt gtctccaaaa ttgcctttat cgcgattggt ataatcgttc atagcttgtt
    21781 ttaaagctga ggcgatacca acataatcaa cgactaaacc accttcttta tccttataga
    21841 cacggttaac acgcgcaata gcctgcatga gattatgacc agacatcggc ttatagacat
    21901 acatggtcgc aagacttgga acatcaaaac cagttagcca catatcaaca acgatagcaa
    21961 tcttgaaagg actattatca tccttaaatt ttttagccag ttcttcttta tgctttttat
    22021 tgcctataag atcatgccat tcttcgggat ctttgttact agaagtcatc acaacaccaa
    22081 ccttatcacc ccaatcagga cgcaagtcaa gtatcttatg ataaatcttc atcgcaatag
    22141 gtctcgaata tgcgacaatc atcgccttcc ccgtcaattc atttttacga ttatcttcgt
    22201 agtgggtgat aatatctgtc actagcgccg aaatggtctg gtcagcacct aaaacactat
    22261 ccagtcgact aagttctctt ttactcctat tgatggcaga atcttcggct tgctctgcca
    22321 acacgtcata ttcggcatca atctcctgca agattttttc atcaaggttg agatgtatga
    22381 cacgactctc atagtagaca ggtctagttg caccgtcctc aacagcctgt gtcatatcat
    22441 aaatatcgat ataatcccca aatacttctg ttgttgattt gtctttactt gaaataggtg
    22501 ttccagtgaa accaatatag gtcgcattgg ggagattatc acggatgatg cgcgctgtcc
    22561 cgattttaaa cttaccagtt gcgggatcaa tcttttcttc taaaccatac tgaccacgat
    22621 gtgcctcgtc agccataacg acgatattat atcgttctga caaggcttcc gatgattctt
    22681 caaacttctg catggttgtg aaaataatcc cgttcgcttg cctaccagat aatagttctt
    22741 taagatgttt acgacttgtc gcttgtactg gtgtttggcg taaaaattga gaacagcggt
    22801 caaattgctt aaacaactga ttatctaaat cattt
//
