LOCUS       NZ_CP065054            16758 bp    DNA     circular CON 17-MAY-2024
DEFINITION  Streptococcus equi subsp. zooepidemicus strain SEZ13 chromosome,
            complete genome.
ACCESSION   NZ_CP065054
VERSION     NZ_CP065054.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus equi subsp. zooepidemicus
  ORGANISM  Streptococcus equi subsp. zooepidemicus
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2150055)
  AUTHORS   Borlee,G.I., Lakin,S.M., Kapuscinski,M.L., Abdo,Z., Stenglein,M.D.,
            McCue,P.M. and Borlee,B.R.
  TITLE     Complete genomes of eight Streptococcus equi subsp. zooepidemicus
            strains isolated from mares in estrus with endometriti
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2150055)
  AUTHORS   Borlee,G.I., Lakin,S.M., Kapuscinski,M.L., Abdo,Z., Stenglein,M.D.,
            McCue,P.M. and Borlee,B.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2021) Microbiology, Immunology, and Pathology,
            Colorado State University, 2025 Campus Delivery, Fort Collins, CO
            80523, USA
  REMARK    Annotation added by submitter
REFERENCE   3  (bases 1 to 2150055)
  AUTHORS   Borlee,G.I., Lakin,S.M., Kapuscinski,M.L., Abdo,Z., Stenglein,M.D.,
            McCue,P.M. and Borlee,B.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2020) Microbiology, Immunology, and Pathology,
            Colorado State University, 2025 Campus Delivery, Fort Collins, CO
            80523, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Coverage                   :: 246
            Sequencing Technology :: Illumina NextSeq;Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015689395.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 02:47:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,059
            CDSs (total)                      :: 1,970
            Genes (coding)                    :: 1,933
            CDSs (with protein)               :: 1,933
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 16 of 37
            Pseudo Genes (incomplete)         :: 20 of 37
            Pseudo Genes (internal stop)      :: 16 of 37
            Pseudo Genes (multiple problems)  :: 14 of 37
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:11:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 783214
            Orig. end                         :: 799972
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP065054.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..16758
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..16758
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..16758
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:11758](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..11758
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    1511..1524
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.15"
                     /tool="antismash"
     misc_feature    complement(1941..1954)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.16"
                     /tool="antismash"
     gene            3883..4542
                     /db_xref="GeneID:83704567"
                     /locus_tag="I2432_RS03740"
                     /old_locus_tag="LJFMMFNO_00747"
     CDS             3883..4542
                     /codon_start=1
                     /db_xref="GeneID:83704567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006627214.1"
                     /locus_tag="I2432_RS03740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00747"
                     /product="DNA-binding protein"
                     /protein_id="WP_206158990.1"
                     /transl_table=11
                     /translation="MDYKTMRDRIEDMVNDNHKEFVKAIISMEKGINDESALDKLYDAY
                     VDNDTVNLLHEEFDYMIEDLREQGQIKDLPYVQEEKDNLINIVGNIVGKVDVVERENKN
                     GEAFKVANFSVVSKDDEGNKVYHNCSAYGEKSDIPKDFKQGDFVKLFGQIKTSIDDNGK
                     EHSNVRILSSKLLKAKEQMKGQEEKKESVLGAIKKYQAEDKEKPKEKKEASKEVER"
     gene            5001..7154
                     /db_xref="GeneID:83704568"
                     /locus_tag="I2432_RS03745"
                     /old_locus_tag="LJFMMFNO_00748"
     CDS             5001..7154
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0043214 - ABC-type bacteriocin transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83704568"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672141.1"
                     /locus_tag="I2432_RS03745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00748"
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="WP_111690012.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.8e-43, bitscore:
                     142.0, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1035.8,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFKKCHYRSQVDMKDCGVATLAMILEYYGSYYSLATLREMAKTT
                     QDGTTALGLVKVAEALHFNTQAIQADMSLFDIENLSFPFIAHVIKNETLLHYYTVIGCD
                     KKNIHIADPDSSVGITKMSRKQFEKEWTGVTLFFIPSNCYKLYKEKKVSLWSFVPVLKK
                     QKLLISQIIGATLFITFINISGSYYLQAIIDNYIPNQMFHVLGIISIGLIIGYMIQQLV
                     SYVQSQLLMILGQRLSIEIILSYIKHVLHLPLSFFSTRRTGEIVSRFTDANAIIEALAS
                     TVLSVFLDVSVAIIVAVILCLQHPLLFLISILSLPIYTLIVFLFMKPFERMNQEVMETN
                     AKLSSSIIEDINGIETLKALSSEDTSYQKIDKEFTVHLKKSFTYYRSENIQKAIKTLLH
                     LLLNVFILWTGSKLVMSNQMTLGQLITFNTMLVYFTNPLENIVNLQTKLQKAHVANARL
                     NEVYQIKSEFLSQQPMIDFKEWKETITFTEVSFRYGYGAEVLSKIDFTIQKGSKVAFVG
                     ISGSGKTTLAKLLVNFYEPTHGEITLDHINLKKIDKKSLRHLITYLPQQPYIFNGTILE
                     NLLLGAPKDTTQKDIIEVLNFVELNTDIFRLPMQLQTELTSDGTELSGGQKQRIALARA
                     LLTKSPILILDEATSSLDVLTEKKIINNLLALDKTILFIAHRLTIAERADRVIVLEKGQ
                     LIEDGTHETLLKKGGFYTHLMNG"
     gene            7186..7347
                     /db_xref="GeneID:83704569"
                     /locus_tag="I2432_RS03750"
                     /old_locus_tag="LJFMMFNO_00749"
     CDS             7186..7347
                     /codon_start=1
                     /db_xref="GeneID:83704569"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2432_RS03750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LJFMMFNO_00749"
                     /product="bacteriocin"
                     /protein_id="WP_172454088.1"
                     /transl_table=11
                     /translation="MLKENKKIKNIENYKKLSNQNLQSITGGAKRSESIIVSICNWLGF
                     CNNKDMRK"
     gene            7347..8660
                     /db_xref="GeneID:83704570"
                     /locus_tag="I2432_RS03755"
                     /old_locus_tag="LJFMMFNO_00750"
     CDS             7347..8660
                     /codon_start=1
                     /db_xref="GeneID:83704570"
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="I2432_RS03755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00750"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_111690014.1"
                     /transl_table=11
                     /translation="MFIDLLGLIFSIMGLLLPRIVLGSRIDGIFLQKRNWLYLFLWHLI
                     VTRINMAFSGIGIIIFYYMIFIIRLKKDKKIALFYSLYLFLAYESIRFFFASVFYRVIS
                     TREMPIFFSEGLDLLLTVFCLLIATLIFKYIRLDKEVLESKRFSVSINYTLWIFFVLSV
                     LRITSSVLTKIKNPFIYEFDTTVSLFIFISYLLTILYLHEKQLSYFHRENIKKKEQENR
                     DLNELIIELGSLYEEIRGFRHDFGGIIACLEPAIEKQNINEIKHIYQHVCLKMNQRLIK
                     AEYTAFNLKQIEDIAFRNVLTQKMLQAKAQKIPFYLEVSNNIPIVEVPMLDTVRLLSIL
                     LDNALEGTEKALYPQITVAIIHDTTTTSVLIQNTRESVVIDKRKIWEKGYSTKGKNRGI
                     GLSSLLDMIYKLGNVDIETIVEEESFTQKLIFRKRGTY"
     gene            8660..9409
                     /db_xref="GeneID:83704571"
                     /locus_tag="I2432_RS03760"
                     /old_locus_tag="LJFMMFNO_00751"
     CDS             8660..9409
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83704571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003094210.1"
                     /locus_tag="I2432_RS03760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00751"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_231146896.1"
                     /transl_table=11
                     /translation="MINIAIVEDNLHHLMRLETILYDLSKEMHIKINIVSSASIEEYQS
                     QLSEKTIYDLYFLDLEIDNNKNKGFDLAKHIRSYNPYGTIVFITTLSEAMPLVFRNHVS
                     ALDFITKDNSESIFRERVKECLKYVLSKNQIQKAEEILSYSYQGRTGIHIPFSDILFIQ
                     TAPTSHKLILFGVNFRKEFYGTIADILKLDTTHCFQQVDRSTIINIENVIEVNSREREA
                     LFYEGTSCSISRLRIKALIEKLKEKEG"
     gene            9751..10278
                     /db_xref="GeneID:83704572"
                     /locus_tag="I2432_RS03765"
                     /old_locus_tag="LJFMMFNO_00752"
     CDS             9751..10278
                     /codon_start=1
                     /db_xref="GeneID:83704572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669430.1"
                     /locus_tag="I2432_RS03765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00752"
                     /product="streptococcin A-M57"
                     /protein_id="WP_206158991.1"
                     /transl_table=11
                     /translation="MKKIFKTLILACSILTISTSLLPSTKVFASESINTEISNISETNI
                     SSQEVDQVAQALELMFDNNVSTSNFKKYVNNNFSDSEIAIAELELESRISNSPSEFRVA
                     WNEMGGCIAGKIRDEFFAMISVGTIVKYAQKKAWKELALVVLKFVKANGLKTNAIIVAG
                     QLALWAVQCGLE"
     gene            11528..11758
                     /db_xref="GeneID:83704573"
                     /locus_tag="I2432_RS03775"
                     /old_locus_tag="LJFMMFNO_00754"
     CDS             11528..11758
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:83704573"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019320866.1"
                     /locus_tag="I2432_RS03775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00754"
                     /product="Blp family class II bacteriocin"
                     /protein_id="WP_010817848.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.3e-14,
                     bitscore: 51.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTQVIDKFEVLDKETLLRVEGGGWLKCGLGTVGGALTGGVAGAA
                     VGTVTLPIIGTVSGSAAGFWGGAATGAATFC"
     misc_feature    complement(11841..11853)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            12302..12463
                     /db_xref="GeneID:83704574"
                     /locus_tag="I2432_RS03780"
     CDS             12302..12463
                     /codon_start=1
                     /db_xref="GeneID:83704574"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2432_RS03780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_206158992.1"
                     /transl_table=11
                     /translation="MDCAAGIGASVATLGVAATTPVGWIGLGALALSGGLSGFASGYSC
                     TALYFEGN"
     gene            complement(13421..14752)
                     /db_xref="GeneID:83704575"
                     /locus_tag="I2432_RS03785"
                     /old_locus_tag="LJFMMFNO_00757"
     CDS             complement(13421..14752)
                     /codon_start=1
                     /db_xref="GeneID:83704575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820672.1"
                     /locus_tag="I2432_RS03785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00757"
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_111690018.1"
                     /transl_table=11
                     /translation="MAITKIHPIKSTLNLAISYIVNGKKTDEQILVSTHKCHQETAHTQ
                     FLRTRNDAGTNGTVLARHLIQSFLPGETTPEVAHQIGLELCKKILKDEYEFVLSTHIDK
                     GHIHNHIIFNNVNMITGKCYQSNKRSYHQIRYQSDKLCKGNNLSVIDESYEAYKKKYKT
                     NGKSWYENEQSKKGTSWKSRLQFDIDHLIKQAKDWEDFLKKMAELGYEIKHGKHIAFKP
                     KDKQRFTRAKTIGEDYTEERLKKRITENRAIKTSSVKKRIGNVINMNTNAKVKESKGYE
                     YWATKHNLNTMAESVIFIREHGINSVKQLDEYIQKSAEERQNLQDKIKEIDKDMQLLSD
                     TMEQVHTVKKYRAYYKEYKANPSDKAFFEEHKAEITRYETALSKLKKSYSKLPNSKDIL
                     NRLDKLQEKKTTLMQEYSSSKTTMDDLNQIRKNYGVYMDKEMDR"
     gene            complement(14758..15108)
                     /db_xref="GeneID:83704576"
                     /gene="mobC"
                     /locus_tag="I2432_RS03790"
                     /old_locus_tag="LJFMMFNO_00758"
     CDS             complement(14758..15108)
                     /codon_start=1
                     /db_xref="GeneID:83704576"
                     /gene="mobC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270454.1"
                     /locus_tag="I2432_RS03790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00758"
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="WP_111690019.1"
                     /transl_table=11
                     /translation="MVNRIRNERLEIKLTEEEKALFEEKRKLAKCRNMSHFIRKCVLEK
                     EIYQVDLEPFRDLQGLLSNATNNINQIAKRINSTGVIYKDDINDMKKQIEHFSKELWQI
                     HSLLLNRTSGGD"
     gene            15412..16311
                     /db_xref="GeneID:83704577"
                     /locus_tag="I2432_RS03795"
                     /old_locus_tag="LJFMMFNO_00759"
     CDS             15412..16311
                     /codon_start=1
                     /db_xref="GeneID:83704577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006524876.1"
                     /locus_tag="I2432_RS03795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LJFMMFNO_00759"
                     /product="YafY family protein"
                     /protein_id="WP_111690020.1"
                     /transl_table=11
                     /translation="MKDNRLFRILYYILEKGKVTARELSDKFEVSVRTIYRDIDSISSA
                     GIPIYATQGKGGGIEIAEDFVLSKSLLSEKEKQQIMSALQGLDNTTIQHENELLTKLSA
                     LFKIKNTSWIEVDFNNWQNNKLYEKTFNDIKSAILSKNIISFTYFSSNEKETNRSVKPV
                     RLLFKSQGWYLYALCLLRNDFRYFKLSRIKNLEIHTENFNDSFEDTILKKEMPHENTVY
                     IKVKFDRKVAFRVYDELNGEITEDNDGNLYTEIEVPNDYNLYNYIFSFGDGAEVLEPKE
                     IRMQIKEMINKMAEKYIT"
ORIGIN
        1 aaacattaga gaagaacaaa acttttacag accgttatct tttaaccctg aagatgggga
       61 tttacctttt gcctgtgcaa atggcagtaa ttcatataaa tatggctatg taacaaaaga
      121 cgagtaccta tcaggaaata tcagagataa gattgcgatt gttgacagtt atctatcaaa
      181 acttagacaa acggaaagag aactacctca tcttggatat gcggaagatg gcaaagaaaa
      241 agaactgata aactatgaaa tgaaccgatt ggaataccaa aaggcggagc ttaccaaagt
      301 tttaccaaag gagcttgaag caagtgaaat caatgtaaga cttggtgcaa cttggatacc
      361 gataaaagat attgaaaagt ttacctttga aacactgaaa actccgggct gggcaagatg
      421 ggatattaag gttaagtttt caaatctcac aagcgaatgg aatattgaag ggaaaagcaa
      481 agacagagga aatgaccttg cagagatgac ctacggtaca agtagagtaa gtgcctataa
      541 gctgattgaa gatgccttaa atcttaaaga aacaaaggta tttgaccaga ttataaatcc
      601 tgacggctcg aaaacttctg tactaaataa aaaggaaact ctccttgcag gacaaaagca
      661 ggagcttcta aaagaagaat ttaagaactg gatatttaat gatcaggaaa gaagaaacag
      721 gcttgtaaag ctatataatg agcgttttaa ctccatcaga aatcgtgaat atgacggcag
      781 taacctttcc tttgagggaa tgaatactaa aatagagctt agacctcatc agagaaacgc
      841 tattgcaaga agtttgtatg gtggaaatac cttgcttgcc catgtggttg gtagtggaaa
      901 gacctttgaa atggtagctt ctgcaatgga atctaaaagg cttggaatgt gtagtaaatc
      961 actctttgtt gtgccgaacc atctgacagg acaaatcggc agagaattta tgcagctcta
     1021 tccatcggca aatattatgg tggcagataa aaaagacttt gagccgaaga acagaaagag
     1081 atttatcgga agaattgcaa caggagagta cgatgcggta gtaatcgggc atacgcagtt
     1141 tgaaaaaatt ccgatgagta aggaatatca gaagaagcat attcaggatc agattgatga
     1201 aatcatcaat tatgttgagg aatataagca tgacagaaat cagaacttta cagtaaaaca
     1261 gcttgaaaag acaaagaaaa agttggaaac aaggcttgag aaattaaatg acgattttaa
     1321 gaaagacgat gtcattacct ttgaggaatt aggcgttgat aagctattta tcgacgaagc
     1381 acacaattac aaaaatctct atctctacac aaaaatgaga aatgtagcag gtattggtca
     1441 aagcgaagcc tttaagtcat ccgatatgtt tatgaagtgc agatatatgg atgaaatgac
     1501 aggtggaaaa ggcattgttt ttgccacagg aacgccagta agtaattcca tgacagagct
     1561 ttataccatg cagcgttatc ttcagtatga aagccttaaa aagaataatt tagagcattt
     1621 tgattcttgg gcatctacat ttggtgaaac acagtctgcc tttgaattat ctccggaggg
     1681 aacagggtac agagttaaaa caagattttc aaagttctat aacctacctg agttaatgtc
     1741 tatgtttaag gaagttgcag atattcagac agcggatatg ctaaatcttc caacacctga
     1801 agcacactat gaggttatta agactttgcc aagtgaggag caaaaggaaa tcctaaagag
     1861 cttatccgaa agagctgatg atgtcagaaa cagagtggta gaacctgatg aagataatat
     1921 gctgaaaata accaatgacg gcaaaaaact tgccttagat cagcgtttaa tcaatccttt
     1981 gctacccgat aatcctgaca gtaaggtcaa tgtctgcgtg aaaaatgtgt ttgccatttg
     2041 ggataagact aaagagaaca agtctacaca gttacttttc tctgatatgt ccacaccgaa
     2101 aggcgatgga gaatttaata tctatgatga tattagagat aaacttgttg caatgggaat
     2161 accgaaagaa gaaattgcct ttattcatga agctaattca gataaacaaa aagatgaact
     2221 ctttgcaaag gtaagaaaag gagatgtgag gatattactc ggctctactc agaagatggg
     2281 agcaggcacg aatgtccaaa acaagttgat tgcactccat gacctcgatg tcccttggcg
     2341 tcctgctgat cttgagcaga gagccggaag aatcgtaaga cagggaaatg aaaataagga
     2401 agtaaacatc tatcgctatg taacggaaaa tacctttgat gcgtatttgt ggcagaccat
     2461 tgagaataag cagaaattca tttcacagat tatgacaagt aaaacgcctg tcagagttgc
     2521 ggaagatgtg gacgaaagct cccttaacta tgcggagatt aaagcactgg cgacaggcga
     2581 tccaaagatt aaagaaaaaa tggacttgga taatgaagtt acgaaactta aaatgctgga
     2641 agcaaacttc aagtccaacc gttacagatt agaggataag gtggctaaaa attatcctga
     2701 agaaatcgca aggatggaaa agttaattga ggctgtaaag aaagatatag caaatgtaga
     2761 gcctaaagca gagggagagg aaaagtttac ttcgattgcc atttttggag agaaaattac
     2821 tgataagaaa ttagccggcg aaagactgct cgaagctatc aagaccgtaa aaatcaatga
     2881 aagtaaggtt atcggtaggt atagaaatat ggatttggaa gtaagctata acttctttac
     2941 caatgctcat aactttagtt taaatggtgc tgcaaagcat tcaggagagc ttggaacaag
     3001 tgcagacggt aatatcacaa gacttgataa tgcccttgag aaaatgcctg aaaaattgaa
     3061 aagactggag gagaagctca caagcacaaa agaacagctt gaaaatgcca aagaagaact
     3121 caaaaagcct tttgaaaagg ctgatgaact aaagaataag gtgttaaggc ttgcagaact
     3181 caataagctg cttgatatgg gagatgtgga agaaaagaga aatgacaatc ctcttgtgga
     3241 agatgttaaa agagccatca ttgatttctg taacagagag tatgaagaaa attatagcta
     3301 tgaggaattt aataccttgt atcctgattt gaagcatata ggcatcgctt ataccgatac
     3361 acctgatgaa aggcatggaa tacaatttga gttaaacctt gaggattata cagctactca
     3421 atatgtaaat gacgttatag taagtcatta tgattatgtc aaagaaaatg gcagcattga
     3481 aaaagctctt gatgttatga aatttgaaat ggaaaacgga gaattcagca ctttcgttgc
     3541 agttgatgaa gatgaattaa gaaaagctac tggaatggag attgatgatg aaggtaactt
     3601 ttatgatcca cttgcaaaag atttagataa tgatggaatt gctgaccgtt atgataatga
     3661 ctttaaggac agtgattatt tcgagtcaac ttatgatgtc gaggataatc ttcatagtaa
     3721 aggagaaact acacaaaaat cagaggacaa gccgtctatt ttaggtcaga taagagccta
     3781 tcaaaatgaa agcaaaacag aagaaaaaca aacaacaaaa gaacatgaat atgtacgata
     3841 aggagcgaaa agctccctta tgccatgaaa ggagataaaa acatggatta caaaacgatg
     3901 agagatagaa tcgaagatat ggtaaatgat aaccataagg aatttgttaa ggcaattatc
     3961 agtatggaaa agggtattaa cgatgaaagt gcattagaca aactatacga tgcctatgtg
     4021 gacaatgaca ccgtcaattt actgcatgag gaatttgact atatgattga agatttaaga
     4081 gaacagggac agataaaaga cctgccatat gttcaggagg agaaagacaa tcttataaat
     4141 atcgttggaa atattgtggg taaggttgat gtagttgaaa gggaaaataa gaacggagaa
     4201 gcctttaagg tggcaaattt ctccgttgta tctaaagatg atgagggtaa taaggtgtat
     4261 cataattgct ccgcttatgg agaaaagagt gatattccaa aggactttaa gcagggagat
     4321 tttgtgaagc tctttggaca aatcaaaact tccattgatg ataatggcaa ggaacatagc
     4381 aatgtaagga tactttcttc aaagctctta aaggcaaagg aacaaatgaa aggacaggag
     4441 gaaaagaaag aatctgtact tggagctatc aaaaaatatc aggctgaaga taaagaaaag
     4501 ccaaaagaaa agaaagaagc atcaaaagaa gttgaaagat aaatatatgg tcggtgtggt
     4561 cttaggactg caccggcttt ttttatgcaa acagagaaga taattgactt aatgaaaaaa
     4621 tacagactaa cgaagaacaa gatatactcc aaaagcttaa cggcattcta aaaaaggatg
     4681 aatagaaata tatttgtaaa caagatgttt tttactaaaa atagtaagaa gacatttata
     4741 agaaatgaat cattacagag gaatagtact gtaggcacag tgttttttat gaagtaaact
     4801 ttatctaagt acttgcaaat atgaataatt acttgtaaaa aataagtgtt aactatatac
     4861 tagctgtgta cagtaataca tttcaggtac aaaaatagac atttcaagca cacatactca
     4921 ttgaaacttt taaatttgct atagtatcga catacaaata cttattatca atttactata
     4981 gaataaaatt aggaggtttt atgagattta agaaatgtca ttatcggtcg caagtagaca
     5041 tgaaagattg tggtgtggct actctcgcaa tgatacttga atattatggt tcgtattatt
     5101 ctttggcaac attaagagaa atggcaaaaa caacacaaga cggaactact gctctaggac
     5161 ttgttaaagt agcggaagcc ttacacttta atacacaagc tattcaagca gacatgtcac
     5221 tatttgacat agaaaatcta tcatttcctt ttattgcaca tgtaataaag aatgaaacac
     5281 ttttacatta ttatacggta ataggttgtg ataaaaagaa tattcatatt gctgatccag
     5341 attcttctgt aggaataacg aaaatgtctc gtaaacagtt tgagaaagaa tggacaggcg
     5401 ttacattatt ttttataccg tctaattgtt ataagctata taaggaaaag aaagttagct
     5461 tatggtcttt tgtacctgtt ttgaagaaac aaaaactact gattagtcag attattgggg
     5521 ctactttatt tataactttt atcaatatta gtggttctta ttacttacaa gctattattg
     5581 ataattatat cccaaatcaa atgtttcatg tattaggaat tatttctata ggattgatca
     5641 ttggttatat gatacaacaa ttagtgtcat atgttcagtc acaattgtta atgatattag
     5701 gacaacgtct atctattgag attattttgt cttatatcaa gcatgtttta catttaccac
     5761 tctctttttt ctcaacccga agaactggag aaattgtttc tagatttaca gatgcaaatg
     5821 caatcataga ggctttagcg agtacagtat tatctgtctt tttagatgtt tctgttgcta
     5881 taatcgtagc agttatttta tgtttacaac atcctctatt atttttgatt agtattctat
     5941 cactgccgat ttatacttta attgtcttcc tattcatgaa gccatttgaa agaatgaatc
     6001 aagaggtcat ggaaactaat gcaaaattat cgtcttctat tattgaagat ataaatggaa
     6061 tagaaactct taaagcatta tcaagtgaag atacaagcta tcaaaaaata gataaagaat
     6121 ttaccgtaca tttaaagaaa tcattcactt actatcgaag tgaaaacata cagaaagcaa
     6181 taaaaacttt actgcattta ttattgaatg tatttatttt atggacagga tcaaaacttg
     6241 ttatgagtaa tcaaatgact ttaggacaat tgattacatt caataccatg ttagtatatt
     6301 ttacaaatcc cttagagaat attgtgaatt tacaaacaaa actacaaaaa gcacatgtgg
     6361 caaatgcacg attaaatgaa gtttatcaaa ttaaatcaga gtttttatct caacagccga
     6421 tgattgattt taaagagtgg aaagagacaa ttacatttac agaggttagt tttcgatatg
     6481 gatatggtgc agaggtttta agtaaaattg attttacgat tcaaaaagga agtaaagtag
     6541 cttttgttgg tatatcgggg tctggtaaaa caactttggc aaagctatta gtaaattttt
     6601 atgaacctac tcatggagaa ataacattag atcatataaa cttaaagaaa atagataaga
     6661 aaagcttacg acatttgatt acttatcttc ctcaacagcc gtatatattt aatggaacaa
     6721 ttttagaaaa tttactatta ggtgcaccaa aagatacaac gcaaaaggat attatagaag
     6781 tattaaattt tgttgaattg aatacagata tctttcgatt gcctatgcaa ttacagacag
     6841 aattaacctc tgacggtaca gaattatctg gtggacaaaa acaaagaatt gctttagcca
     6901 gagcattgct tacaaaatca cctatattaa ttttagatga agcaacaagt agtttagatg
     6961 tattaacaga gaaaaaaata attaacaatc tattagcatt agataaaacc attttattca
     7021 ttgctcaccg tttaacaatt gcggaacgag cagatcgtgt cattgtgtta gagaaaggac
     7081 agctcattga agatggtaca catgaaacac tgctaaaaaa aggcggtttc tatacccatt
     7141 taatgaatgg ttaaaatttt aaaaaattta agaaggagag tatttatgtt gaaagaaaat
     7201 aaaaaaataa aaaatataga aaactataaa aagttgtcaa accaaaattt acagagtatt
     7261 acaggaggag caaaacgttc agaaagtatt attgtatcca tctgtaattg gttaggtttt
     7321 tgtaataata aggatatgag aaaataatgt tcattgattt attgggattg attttttcga
     7381 ttatgggttt gcttcttcct agaatcgttt taggaagtcg aattgacgga atatttcttc
     7441 aaaagagaaa ttggctatat ttatttttat ggcatttgat tgttacaaga atcaacatgg
     7501 cgtttagtgg aattggaata attatttttt attacatgat tttcattatt cgcctaaaaa
     7561 aagataagaa aatagccttg ttttactctc tatatttatt cttagcttat gaatccattc
     7621 ggttcttttt tgcgagtgta ttttatcgtg taatttcaac aagagagatg ccgatctttt
     7681 tttcagaagg attagattta ctattaacag tattctgctt attgatcgct acattaatct
     7741 ttaaatatat aagactagat aaagaagtat tagaatctaa gcgtttttca gtctccatta
     7801 attatacttt atggatattt ttcgttttaa gtgttttgag gattacatct tcggtattaa
     7861 cgaaaatcaa aaatccattt atttatgaat ttgatacaac ggtatctttg tttattttta
     7921 ttagttatct attaactatt ttatatcttc atgaaaaaca actaagctat ttccatcgag
     7981 aaaatattaa gaaaaaagaa caagagaatc gagatttaaa cgaattgatt atagagttag
     8041 gttcactcta tgaagaaata cgaggattta ggcatgattt tggtggtatt atcgcctgct
     8101 tagaaccagc gatagaaaaa caaaatatta atgaaattaa gcatatctat cagcatgtgt
     8161 gccttaaaat gaatcaacgt ttgataaagg cagagtatac agcttttaat ttaaagcaaa
     8221 tagaagatat tgcctttaga aatgtattga cacaaaaaat gcttcaagca aaagctcaaa
     8281 aaattccttt ttatttggaa gtatcgaaca atattcctat tgtagaagtg cctatgttgg
     8341 atacagttcg tttattaagt attttattgg ataatgcatt agaaggaaca gaaaaagcac
     8401 tgtatccaca aattacagtc gcgattattc atgatactac tacaacttct gttttgattc
     8461 agaatacaag agaatctgtt gtgatcgata agcgaaaaat ttgggaaaaa ggatattcta
     8521 caaagggaaa aaatagagga attggattat cttctttgtt agatatgatt tacaaattgg
     8581 gaaatgtaga tattgaaacg attgttgaag aagaatcttt tactcaaaaa ttaattttta
     8641 gaaagcgagg tacttattaa tgatcaatat tgcgatagta gaagataatc ttcatcatct
     8701 tatgcgatta gaaaccatat tgtatgatct ttcaaaagaa atgcatataa aaataaatat
     8761 agtcagttca gcaagtatag aagaatatca atcacaatta tctgaaaaaa cgatatatga
     8821 tttgtatttt cttgacttag aaattgataa taataaaaac aagggatttg acttagctaa
     8881 acatatcaga agctataatc cctatggaac aattgtgttt attacaacat tgtctgaggc
     8941 aatgccttta gtttttagaa atcatgtatc cgctttagat tttataacaa aagataatag
     9001 tgaatctatt tttagagaac gtgtcaaaga gtgtctaaag tacgtattgt ctaaaaatca
     9061 aatacaaaaa gcagaagaaa ttttaagtta ttcatatcaa ggaagaacgg gtattcatat
     9121 ccccttttcg gatattttat tcattcaaac agcccctact tcccataaat taatcctttt
     9181 tggcgttaat tttagaaaag agttttatgg aactatagca gatattttaa agttagatac
     9241 aactcactgc tttcaacaag tagatcgttc aacaattata aatattgaaa atgtaattga
     9301 agtaaattca cgtgaacgag aggcattatt ctatgaagga acaagctgtt ctatttccag
     9361 attaagaatc aaagcactaa tagaaaaact aaaagaaaaa gagggctaat gcatgtgtta
     9421 gtcttctttt tatatacaat gataaaaaga agacatttca ggcacaaaaa tcatacattt
     9481 taggcacaca tgctctataa cgtttataaa atgctagact ataaacaaga aatgattgaa
     9541 ggggaggata aaagatgatt tgtttttcag taccgcctta aataatatct atgccaataa
     9601 tctgatttat ttttgtattt gaaaagaata gagaagttag gagcaactgc ataaataaaa
     9661 aacaaacaag atttgaaaaa aagtatatgt aatttagcag atatactatt gtaaaacaaa
     9721 atttatttta tagaattgga gtgatttttg atgaaaaaaa tttttaaaac attaatactt
     9781 gcttgtagta ttttaactat atctactagc cttcttccat ctacaaaagt gtttgcaagt
     9841 gaatctatca atactgaaat ttcaaatatt tctgaaacaa atatctcatc tcaagaagta
     9901 gatcaagtag ctcaagcttt agaattgatg tttgataata atgtatcaac atctaatttt
     9961 aaaaaatatg ttaataataa tttttctgat tctgaaattg ctattgctga attagaatta
    10021 gaatctagga taagtaattc tccttcggaa tttcgagttg catggaatga aatgggaggg
    10081 tgtattgctg ggaaaataag agatgaattt tttgctatga ttagtgtagg aacaattgta
    10141 aaatatgcac aaaagaaagc ctggaaagag ttagctttag ttgtattgaa attcgttaaa
    10201 gctaatggac taaaaacaaa tgcaataatt gtagctggtc aattagcttt atgggctgtt
    10261 caatgcggat tagagtaatg atggaaagaa aaaaattatt ttttgactgt ataatatcaa
    10321 ctataattag ttttataatg gttttctttc ttttagaaaa atttgattta tggaaaagca
    10381 taatattttc tattgtattt gtttttgttg ctactattat tccttatttt attcataaga
    10441 aaaaagaata ataatatagt ttaactttaa aaatatctaa tatatgacta ctaacttagt
    10501 caattctgaa attttagtct tctagagtaa ctgaaaaaga taaagtcaaa ataggaaaca
    10561 gacggagtga atctgtggtg tgtgaattac caaggccccg ttatctaata tgtagatagt
    10621 cctacttcac atcccgtcta ttctatccaa caggttaaaa atcacctatc tgatacaata
    10681 aaatataagg tatatgtttc taatagcata tatctttttt tgattggagg aattaacatg
    10741 aataatacag aatttattga aaaattaaaa caataaagaa ctggctgtga ttattcacaa
    10801 gcaagactag taagagaact ttatatcagt agacaaaatt taaatgaaat tgaaagtggt
    10861 aaagtaaaag ccagtcgaga aatgtgacgt ttactgttac attatcttga ttaccatcaa
    10921 tgtaaacaga ccgtttacac taatgattga ttatttgcat attcgcttcc ctattacaga
    10981 cgcattggaa attattaaag tagatatttt aaagttagat acaactcatt attttcagta
    11041 agtagatcgt tcaacaatta taaatattga aaatgtaatt gaagtaaatt cacgtgaacg
    11101 agaggtatta ttctataaag gaacaagctg ttctatttcc agattaagaa tcaaagcact
    11161 aatagaaaaa ctaaaagaaa aagagggcta atgcatgtgt tagtcttctt tttatataca
    11221 atgataaaag gaagacattt caggcacaaa aatcatacat tttaggcaca catgctctat
    11281 aacgtttata aaatgttaga ctataaaaaa agatgattga aggagaggat aaaagatgat
    11341 ttatttttca ataccgcctt aaataatatc tatgttaaca atcgtattat ttctagtttt
    11401 ctaaaaatgg agatatataa ctcgtacaag ttttacattt ccatatttat atagttgaca
    11461 ttaaagaaat tgttgttaaa ttaaggaata aaactataaa aatattatta gttaaaagga
    11521 gaaaaatatg aatacacaag tgattgataa atttgaagtt ttagataaag agactctttt
    11581 aagagttgaa ggtggtggat ggcttaaatg tggattagga acagtaggag gtgctctaac
    11641 aggaggagtt gcaggagcag cagttggtac agttacatta ccaattattg ggacggtatc
    11701 tggaagtgca gcaggattct ggggaggagc ggctacaggt gcagccacat tctgttaatt
    11761 aaaaaatata tttcttaaaa ggaatgatta gatggagaaa aggatagtat cttttattat
    11821 tacaatagga attcttatag tttcaatatg caattttttt aaagaattaa gtttattact
    11881 tcttgtttta aactctgtag gattctttat atttattgtt attttaattg ccaatatgaa
    11941 gtatgtaatt tttagtagag ataaatatta agaaatatgc taatacccct tttaataatg
    12001 attcaatgat aaaaatatat tcttctgttt cgttcaataa aacagaagaa tatatttggt
    12061 cagaaatttt ttctttccaa taattaggaa ataatccttt tatactttaa atagatatca
    12121 aataataaaa agatataagt ataagatata taggaattaa aactagtgat tggtttataa
    12181 atagataaag catatttaaa aatattaatg aagtaaagga aatgtgatta taatgaaaat
    12241 cgaggatttt aaaacattaa acttaaatga attataaaac atttacggag gtggtaatgt
    12301 tttggactgt gctgcaggaa ttggcgcatc agtggcaaca ctgggagttg ctgctacaac
    12361 gccagttggc tggataggtc ttggagcatt agctctttct ggagggctaa gtggatttgc
    12421 atctggatac tcatgtacag cgctctattt tgaaggaaat taggagggat atagtatgta
    12481 taaaaaacta aaatttgatg agctaacaaa tattattggg ggaggaaata ttttagtgca
    12541 agtggtacac tcacaggtgg tgttgcagct tctgctttaa ctggtcccgg ttttgttttt
    12601 ggtcttattg gatcgggagt tgctgcattt gctaccggat attcatgtgc agcgttgtac
    12661 tatgaaggtg attaaatgga aaaatggact attaaaaaaa agaaggctgg tctcgctatc
    12721 tcattttttc ttctatcact tgttcttatt tcacgtattt ctaacaataa tagtttattg
    12781 aattatatat atgggatagg agctatctca ttcttattag aagtgttatg gataatcttt
    12841 cataaaagaa aatagatctg aaatggattc ttctgtctgt gagtaagcct gtggtgagca
    12901 atgataaagc ctccgttatc tagcaatagg acaaagaaac tggaaacgat gtacacaata
    12961 tcctgtattt atacagtgta tctgcatttt taaaggtgtg aagtaatatg actactaacg
    13021 tagtcaattc tgaaatttta gtctgctaga ataactaaaa aaagataaag tcaaaatagg
    13081 aaatagacag agtgaacctg tggtgtgtga attaccaagg ccccgttatc taacaggagg
    13141 agttacagga gtagtagttg gtacagttac attaccaatt attggggacg gtatctggaa
    13201 gtgcagcagg attctaggaa ggagcggcta caggtgcagc cacattctgt taattaaaaa
    13261 atatacttct taatatgaac aataaagatt ttatacaaga agtgaaagaa gaaaaaacac
    13321 taccccttat aaacagggat atattgacgg tttgtgatag ttataaacag atactgaaaa
    13381 atctatactg cttttactat agaaaaataa ggaggtgtaa ctatctatcc atctctttat
    13441 ccatatatac tccatagttt tttcgtatct gattaagatc atccatcgtg gtttttgagg
    13501 aagaatactc ttgcattagg gtagtctttt tttcttgcag tttatcaagt ctatttaaaa
    13561 tatcctttga atttgggagt ttggaatagg attttttcag cttggaaaga gccgtttcgt
    13621 agcgtgtgat ttcagcctta tgctcctcaa aaaatgcctt atcggatgga ttagctttat
    13681 attctttgta gtaggctcga tattttttaa cagtatgaac ttgttccatc gtatcagaaa
    13741 gtagctgcat atccttatca atttctttga ttttatcttg caggttctgt ctttcttcag
    13801 cacttttttg aatgtattca tcaagttgct taacggagtt aatgccatgt tctctgatga
    13861 aaataaccga ttcagccatt gtgtttaagt tatgcttggt tgcccaatat tcatagcctt
    13921 tgctctcttt tactttggca ttggtattca tattgatgac attgccgatt cgttttttga
    13981 cagatgaggt tttaatggct cgattttctg taatacgctt ttttaatctt tcttcggtat
    14041 aatcttcacc gatagtctta gctcttgtaa atctctgctt atcttttggc ttaaaggcta
    14101 tgtgttttcc atgttttatt tcataaccaa gttcagccat tttctttagg aaatcctccc
    14161 aatctttagc ctgttttatc agatgatcaa tgtcaaattg aagtctgctt ttccaagaag
    14221 tgcctttctt agactgctca ttttcgtacc atgacttgcc atttgttttg tattttttct
    14281 tgtaggcttc ataggactca tcaataacag aaaggttgtt tcctttgcat agcttatcgc
    14341 tttgatacct gatttgatga tagcttcttt tgttagattg gtagcatttg ccagtaatca
    14401 tatttacatt attgaagatg atatggttat gaatatgtcc tttatctatg tgagtagata
    14461 agacaaactc gtactcatct ttcaatatct ttttacacag ttcaagaccg atttgatgtg
    14521 ccacttcggg tgtggtttct cctggtaaaa aggattgaat aaggtgtctg gcaagaacag
    14581 ttccgtttgt gccagcatca tttcgtgttc ttaaaaactg tgtatgagca gtttcctgat
    14641 gacatttatg agtgcttact aagatctgct catctgtttt tttgccatta acaatgtatg
    14701 aaatggcaag attaagggtt gattttatag gatgtatttt tgtgatagcc ataaaaacta
    14761 atcacctcct gaagtcctgt tgagcagtag tgaatgtatt tgccatagtt cttttgaaaa
    14821 atgttcaatc tgttttttca tatcatttat atcatccttg tagattacgc cggtagaatt
    14881 tatacgcttt gcaatctgat ttatgttatt tgttgcgttt gaaagcaagc cttgcaaatc
    14941 tctgaaaggc tctaaatcta cttgatatat ttctttttct aaaacgcatt tgcggataaa
    15001 atggctcata tttctgcact ttgcaagttt tcttttctcc tcaaaaagag ctttttcttc
    15061 ttcggtcaat ttgatttcaa gtcgttcatt tcgtattcta tttaccatag gtaaatcctc
    15121 ctttaggtgt atttcggggt cttagggttc tccctaacaa gctaaaaatt gataaaaaaa
    15181 gaagcagctc ccgaaggtct gcttcatcaa ttttttcgta agtgtccgta cacttactgt
    15241 gcttgctaca aaagaatgaa tcagatagca agctttaagc aagttttaat tatatgcttt
    15301 tattatacta aatgagataa gtaatgtcag cggaattggg aaaaatattt tataacatga
    15361 caatagatgt caagttattg tggtataata aaaacaggag atgttaagac gatgaaagat
    15421 aataggctat tcaggatact gtattacatt ttagaaaaag gaaaagttac ggcaagagaa
    15481 ctttcagata aatttgaggt gtcagtcaga acgatttatc gagatattga ctctatcagc
    15541 agtgccggta ttcccattta tgccacacaa ggaaagggtg gtggaataga aattgccgaa
    15601 gattttgtgc ttagtaaatc gttgctgtct gaaaaagaga aacagcaaat tatgtcagct
    15661 cttcaaggat tagataatac gacaatacag catgagaatg agctgctaac aaaactttct
    15721 gcgctcttta aaataaagaa taccagttgg atagaagttg attttaataa ttggcaaaac
    15781 aataagctgt atgaaaaaac attcaatgat attaagtctg ctattttaag taagaatatt
    15841 atttcattca catattttag cagcaatgaa aaagaaacaa acagaagcgt taaacctgtg
    15901 agattacttt tcaagagtca gggctggtat ctatatgcct tgtgtttgct tagaaatgat
    15961 tttagatatt tcaaattgtc tcggataaag aatttagaaa ttcatactga aaattttaat
    16021 gacagttttg aagatacaat actcaaaaaa gaaatgccac atgagaatac agtgtatata
    16081 aaagttaagt ttgatcgtaa agttgccttc agggtatatg atgagttaaa cggagaaatt
    16141 acagaagata atgacggaaa tttatataca gaaatagaag ttccaaatga ttacaactta
    16201 tataactata ttttttcttt cggagatgga gcagaagtat tagagccaaa agagatacga
    16261 atgcagatta aagaaatgat aaataaaatg gcagaaaaat atataacttg acaaacggtg
    16321 tcaagtatcc tcctgtataa tttaattaac caagatgcaa atggaggatt ggataatgaa
    16381 atatgaatgg agaaaacaag aaaaaaatct ttatggtgtg aagcagacac ctatcattgt
    16441 agaagtgaca aagcaaaaat ttattttggt aaaaggtaaa ggaaatccga atgaagcaga
    16501 tttctcagac agaatatctg cattatattc tcttgcctat gccattaaaa tgtcgtttaa
    16561 aaatgcaatg aaaaataaaa ctgataacga gattacagat tttacggtat atccattaga
    16621 gggattttgg aaaaaagtaa attgagaaga gcttgataaa aataaactgg aatacacatt
    16681 gatgattaaa caacctgatt ttattacaca agagatattc gcaaaggcac ttgagaatat
    16741 aaaaaagaaa aagcttaa
//
