GCF_015668115.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JADPFA010000001.1 (Streptococcus salivarius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	lassopeptide	80,009	104,225	High	cochonodin I	ribosomal:RiPP
Region 10.2	T3PKS	212,923	254,089

NZ_JADPFA010000002.1 (Streptococcus salivarius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	RiPP-like	113,417	132,266

NZ_JADPFA010000004.1 (Streptococcus salivarius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	RiPP-like	36,520	48,676
Region 15.2	RiPP-like	75,154	87,250

NZ_JADPFA010000006.1 (Streptococcus salivarius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	terpene-precursor	23,263	44,135

No secondary metabolite regions were found in these records:: NZ_JADPFA010000010.1 (Streptococcus salivarius); NZ_JADPFA010000011.1 (Streptococcus salivarius); NZ_JADPFA010000012.1 (Streptococcus salivarius); NZ_JADPFA010000013.1 (Streptococcus salivarius); NZ_JADPFA010000014.1 (Streptococcus salivarius); NZ_JADPFA010000015.1 (Streptococcus salivarius); NZ_JADPFA010000016.1 (Streptococcus salivarius); NZ_JADPFA010000017.1 (Streptococcus salivarius); NZ_JADPFA010000018.1 (Streptococcus salivarius); NZ_JADPFA010000019.1 (Streptococcus salivarius); NZ_JADPFA010000020.1 (Streptococcus salivarius); NZ_JADPFA010000003.1 (Streptococcus salivarius); NZ_JADPFA010000005.1 (Streptococcus salivarius); NZ_JADPFA010000007.1 (Streptococcus salivarius); NZ_JADPFA010000008.1 (Streptococcus salivarius); NZ_JADPFA010000009.1 (Streptococcus salivarius)

Compact view

NZ_JADPFA010000001.1 - Region 1 - lassopeptide

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Location: 80,009 - 104,225 nt. (total: 24,217 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002575.2	0.89	ribosomal	cochonodin I	Streptococcus suis
BGC0001496.3	0.53	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0001634.3	0.51	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001176.4	0.51	ribosomal	streptomonomicin	Streptomonospora alba
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001645.3	0.50	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001889.2	0.49	ribosomal	fusilassin	Thermobifida fusca YX
BGC0002298.2	0.49	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0002151.2	0.49	ribosomal	alboverticillin	Streptomyces griseocarneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002575.2	0.89	ribosomal	cochonodin I	Streptococcus suis
BGC0001496.3	0.53	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0001634.3	0.51	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001176.4	0.51	ribosomal	streptomonomicin	Streptomonospora alba
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001645.3	0.50	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001889.2	0.49	ribosomal	fusilassin	Thermobifida fusca YX
BGC0002298.2	0.49	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0002151.2	0.49	ribosomal	alboverticillin	Streptomyces griseocarneus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.75 out of 25.88

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 27.47 out of 30.25

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.45 out of 25.88

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25

Confidence: medium

Additional weak hits (1):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 6 - 83; Score: 75.1; RRE type: Thurincin_rSAM_RRE; Location: 16 - 82; Score: 29.0; RRE type: Subtilosin_rSAM_RRE; Location: 8 - 78; Score: 28.9

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_JADPFA010000001.1 - Region 2 - T3PKS

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Location: 212,923 - 254,089 nt. (total: 41,167 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

I4U27_RS01095: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: glycosyltransferase transferase

I4U27_RS01025: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

I4U27_RS01050: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

I4U27_RS01055: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Ligases: synthase

I4U27_RS01100: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: permease

I4U27_RS01130: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000255.5	0.41	PKS	pederin	Uncultured bacterium
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0000016.4	0.38	other (other)	amphotericin B	Streptomyces nodosus
BGC0001080.5	0.37	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000781.3	0.37	saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000286.3	0.36	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0002594.2	0.34	PKS	orcinol, orsellinic acid	Fusarium graminearum PH-1
BGC0000896.5	0.34	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000872.5	0.33	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000255.5	0.41	PKS	pederin	Uncultured bacterium
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0000016.4	0.38	other (other)	amphotericin B	Streptomyces nodosus
BGC0001080.5	0.37	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000781.3	0.37	saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000286.3	0.36	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0002594.2	0.34	PKS	orcinol, orsellinic acid	Fusarium graminearum PH-1
BGC0000896.5	0.34	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000872.5	0.33	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.53 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.85 out of 28.19

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.16 out of 30.25

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.43 out of 32.93

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.57 out of 25.75

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.24 out of 39.62

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JADPFA010000002.1 - Region 1 - RiPP-like

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Location: 113,417 - 132,266 nt. (total: 18,850 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: esterase

I4U27_RS03045: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.44	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001843.2	0.43	NRPS	tridecaptin M	Paenibacillus sp. M-152
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000541.5	0.42	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000449.5	0.42	NRPS	tridecaptin	Paenibacillus terrae
BGC0000624.3	0.42	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001555.4	0.42	ribosomal	colicin V	Escherichia coli chi7122
BGC0000571.3	0.42	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002323.2	0.41	ribosomal	nisin J	Staphylococcus capitis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.44	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001843.2	0.43	NRPS	tridecaptin M	Paenibacillus sp. M-152
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000541.5	0.42	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000449.5	0.42	NRPS	tridecaptin	Paenibacillus terrae
BGC0000624.3	0.42	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001555.4	0.42	ribosomal	colicin V	Escherichia coli chi7122
BGC0000571.3	0.42	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002323.2	0.41	ribosomal	nisin J	Staphylococcus capitis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.40 out of 26.06

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.81 out of 27.18

Confidence: medium

Additional weak hits (5):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.94 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.70 out of 28.14

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
NrdR	Represses ribonucleotide reductase encoding genes

NZ_JADPFA010000004.1 - Region 1 - RiPP-like

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Location: 36,520 - 48,676 nt. (total: 12,157 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

I4U27_RS06425: hydrolase

smcogs: SMCOG1179: hydrolase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.46	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000624.3	0.40	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.39	ribosomal	lactococcin G	Lactococcus lactis
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.39	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.39	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001861.4	0.39	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.46	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000624.3	0.40	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.39	ribosomal	lactococcin G	Lactococcus lactis
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.39	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.39	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001861.4	0.39	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.16 out of 27.78

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JADPFA010000004.1 - Region 2 - RiPP-like

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Location: 75,154 - 87,250 nt. (total: 12,097 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.43	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002577.2	0.39	ribosomal	lactococcin G	Lactococcus lactis
BGC0000588.5	0.39	ribosomal	microcin L	Escherichia coli
BGC0000484.5	0.39	ribosomal	glycocin F	Lactobacillus plantarum
BGC0001861.4	0.39	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.39	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.39	ribosomal	gassericin E	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.43	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002577.2	0.39	ribosomal	lactococcin G	Lactococcus lactis
BGC0000588.5	0.39	ribosomal	microcin L	Escherichia coli
BGC0000484.5	0.39	ribosomal	glycocin F	Lactobacillus plantarum
BGC0001861.4	0.39	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.39	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.39	ribosomal	gassericin E	Lactobacillus gasseri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

Additional weak hits (6):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.58 out of 32.74

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.45 out of 30.97

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.78 out of 32.74

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.09 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.10 out of 39.62

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
ToxT	Regulator of MSHA biosynthesis

NZ_JADPFA010000006.1 - Region 1 - terpene-precursor

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Location: 23,263 - 44,135 nt. (total: 20,873 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

I4U27_RS08225: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Isomerases: mutase

I4U27_RS08330: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

I4U27_RS08345: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthetase

I4U27_RS08280: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0000231.5	0.37	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000800.5	0.37	saccharide	xanthan	Xanthomonas campestris
BGC0000633.3	0.37	terpene	carotenoid	Streptomyces avermitilis
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0000905.5	0.37	other (other)	heme D1	Heliobacillus mobilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0000231.5	0.37	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000800.5	0.37	saccharide	xanthan	Xanthomonas campestris
BGC0000633.3	0.37	terpene	carotenoid	Streptomyces avermitilis
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0000905.5	0.37	other (other)	heme D1	Heliobacillus mobilis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

I4U27_RS08280: PT_FPPS_like

Domain 1 (26 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.87 out of 26.06

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 27.21 out of 33.14

Confidence: medium

Additional weak hits (3):

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.49 out of 35.63

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.75 out of 33.14

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.43 out of 32.38

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ZuR variant 2	Zinc-responsive repressor