LOCUS       NZ_JADPFA010000002     18850 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptococcus salivarius strain D43t1_170807_H4
            NODE_2_length_426189_cov_29.984, whole genome shotgun sequence.
ACCESSION   NZ_JADPFA010000002
VERSION     NZ_JADPFA010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus salivarius
  ORGANISM  Streptococcus salivarius
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 426189)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 426189)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 27.95x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 10:18:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,053
            CDSs (total)                      :: 2,002
            Genes (coding)                    :: 1,964
            CDSs (with protein)               :: 1,964
            Genes (RNA)                       :: 51
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 38
            CDSs (without protein)            :: 38
            Pseudo Genes (ambiguous residues) :: 0 of 38
            Pseudo Genes (frameshifted)       :: 13 of 38
            Pseudo Genes (incomplete)         :: 30 of 38
            Pseudo Genes (internal stop)      :: 9 of 38
            Pseudo Genes (multiple problems)  :: 12 of 38
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:50:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 113416
            Orig. end                         :: 132266
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADPFA010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18850
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..18850
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18850
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:13850](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..13850
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(681..694)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.4"
                     /tool="antismash"
     gene            1215..2081
                     /locus_tag="I4U27_RS03020"
     CDS             1215..2081
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003093752.1"
                     /locus_tag="I4U27_RS03020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_045769186.1"
                     /transl_table=11
                     /translation="MNTILRACHLNKSFGKQEVLTDLNFEIQRGDIVGLIGKNGCGKTT
                     LMKMILGLTPRTKGKIQFKGDSEYNTKRNSLNKIGFLLDCKLFEDFSAYDNLKLFSMYS
                     SSFDKSGLDKRINKLLKFVGLDSSKKLVKSYSFGMKQRLGLALALLDDPEFLILDEPFV
                     GLDPAGVRVLLDYIVKLRREKRVTILISSHQLHEIEEICDYFLFINGKSIETHTKLGKN
                     KIIITLEYAVPELEQSLSKLVTLKEGQIILPHDMMLLNSILRLIYKYNCEIKEITVSDS
                     IEELFRG"
     gene            2086..2838
                     /locus_tag="I4U27_RS03025"
     CDS             2086..2838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376194.1"
                     /locus_tag="I4U27_RS03025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="membrane protein"
                     /protein_id="WP_045769187.1"
                     /transl_table=11
                     /translation="MQSIVLAELYKLLKRKNFIILAILSLWSLIYGFGAFLHWDFVKIG
                     AKLDLVTFITTMWTFLLILTIPLLLILYTSSFILGGEIQGGQILLEVNRVTSKKILIVS
                     KYIVVILSILFLYILNCLTSLVTYICFISHTEFGYTRFWELHATNVQSIVVSLVNLGFI
                     ILLASIAFYLSLNISAIMASFASLGVYFLCQLLSNITMISKFIPGYFFVVPNYHFTIGL
                     SLIHLLSYFLLCILLLIATMKGFESKAL"
     gene            2876..3604
                     /locus_tag="I4U27_RS03030"
     CDS             2876..3604
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535514.1"
                     /locus_tag="I4U27_RS03030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_155198277.1"
                     /transl_table=11
                     /translation="MYKVAICDDDSLQVSNLETHISEYFDEINVQYEIDGYYKGDRMVN
                     TMSGQIDNYHLIFLDIEMEGLNGIETAKLLRNIDKNFILIFVTSFEQYALESFEVSPFR
                     YLIKPVSIEKLREVLRDVLVELTAKQKFMFYQIGTEHFQMSLDNIVCLYSEFGRKIHLE
                     LVSGSDTSFYGRISAIEKELPSTHFVRVNSGTMINLNHISSFNQNDVTMINGNCIAISR
                     SRKKAVRTAYSHFIERSFGL"
     gene            3601..4854
                     /locus_tag="I4U27_RS03035"
     CDS             3601..4854
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004183380.1"
                     /locus_tag="I4U27_RS03035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_195914544.1"
                     /transl_table=11
                     /translation="MIDVYKSVGLLSLFLFQSFVVWFYLQHFFVIRISKSKFYCLILFV
                     YFIGHASITINHNTLLDFKILSLLLTFLILFLFLSGDVMKKVFHYLFLIFWFLIQEDIA
                     ILLLHQVQQTKEIVIFFAQFFLMLLTLLFVLGLKHFKIDNLFELNKIEYGILSLPPFLS
                     IILLLYKMPLPLSRVLIFDSYLLLINIVIIVLYNYLSEKNYNIIKGKIAFDENSMTSEI
                     IQQEEELAILRHDLKNIVSSIDFYADSNDFGNIKAITREILGQEVFNRKITGCIPIDAI
                     LNQKISKMKKDGVQFHLDLQIPYNLDISSIAIDSCAILGNIIDNAIEEIERNGLTNPIE
                     IVLRFKNNKLVFKVANPILTSEIDINYNGMKSIKLPNRRGLGIKSSYDRIMKLKGHLNI
                     NIQSNQFVVLVVIPLKIK"
     misc_feature    complement(4902..4917)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            5001..5231
                     /locus_tag="I4U27_RS03040"
     CDS             5001..5231
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884558.1"
                     /locus_tag="I4U27_RS03040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Blp family class II bacteriocin"
                     /protein_id="WP_002884558.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 5.2e-09,
                     bitscore: 31.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQIINNFNSLNSEDLSTVKGGACSFWGATAAVGVGAVGGAIKG
                     GIQTGTWQGAALKGIGYGIKDGITYGLICRY"
     gene            5505..6860
                     /locus_tag="I4U27_RS03045"
     CDS             5505..6860
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884653.1"
                     /locus_tag="I4U27_RS03045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphatase"
                     /protein_id="WP_175060883.1"
                     /transl_table=11
                     /translation="MKDTIRILHINDLHSHFEQYPQLKRAVDDLSQTDRELIKVDLGDN
                     VDKSHPLSDATAGRFNVALMNELGIDYATIGNNEGIGLAKEELDCLYEQAKFQPIIGNL
                     KDEGRQPEWAKPYIIHKTKAGTNIAFLAYTFPYYITYAPNGWQVLEPMARLEEDLGRPE
                     VRDADIVVVLSHLGVRYDEQIAETYPQVNLVIGSHTHHLFEEGKLVNETYLAAADRYGY
                     YLGCIDLTVENGRLIECQIEAIPTKSYILDLDKEDEVFIKAMREEGHRRLAQKKVANLG
                     RELDFDETCQLVLQAVCQETDSQLTLLNTGLIMKTLGPQVTMADLQEALPHQMRMARLV
                     VTGQELKEICQEVFTKAELLKNQAIKGMGFRGKIFGEVITGNFAYKNGNLLYNRRVVDS
                     NEKFSLVLVDQYYFASYFPTIKEKEVTLLFPDLLRELVAKYLGKNGANWDKI"
     gene            6915..7643
                     /locus_tag="I4U27_RS03050"
     CDS             6915..7643
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621927.1"
                     /locus_tag="I4U27_RS03050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YutD family protein"
                     /protein_id="WP_014634996.1"
                     /transl_table=11
                     /translation="MRKEILPEMFNYNKYPGPDFVYVADLLKSDACQFTVLENHKDALD
                     ATRFGQRFSEIMLKYDYIVGDWSNDQLRLKGFYEDERPNTRKTDRISRLSEYLREYCAF
                     GCAYFILKNEEPQLIVFEEETEPRRKRRRSNNRRNSSQESRDRERNASQKNKGQKASAK
                     QKPDKSKRRDRDQEGPSFEKIKRRPKFKSRSEDGGRERKPNFKKSQKQAPKSKGQNTPS
                     KKQSQTKSDGQHFTIRKKGN"
     misc_feature    6945..6960
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.94"
                     /tool="antismash"
     misc_feature    complement(6947..6960)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.7"
                     /tool="antismash"
     gene            7707..8816
                     /gene="rlmN"
                     /locus_tag="I4U27_RS03055"
     CDS             7707..8816
                     /EC_number="2.1.1.192"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0016433 - rRNA (adenine) methyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0031167 - rRNA methylation [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002888240.1"
                     /locus_tag="I4U27_RS03055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="WP_096832658.1"
                     /sec_met_domain="PF04055 (E-value: 5.9e-20, bitscore: 66.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.7e-07, bitscore: 24.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGYKPSIYGLTRDELIDWAMEHGEKKFRATQIWDWLYKKRVQSF
                     EEMTNISKDFIAKLNENFCVNPLKQRIVQESKDGTVKYLFELPDGMLIETVLMRQHYGL
                     SVCVTTQVGCNIGCTFCASGLIKKQRDLTAGEIVAQIMLVQKYFDDRGDGERVSHVVVM
                     GIGEPFDNYDNVLRFLRTINNDNGLAIGARHITVSTSGLAPKIKEFANEGVQVNLAVSL
                     HAPNNDLRSSIMRINRSFPLEKLFEAIEYYIQTTNRRVTFEYIMLNEVNDHPENAQELA
                     DLTKKIRKLSYINLIPYNPVSEHDQYSRSTKERVAAFYDVLKKNGVNCVVRQEHGTDID
                     AACGQLRSNTMKRDRQKAVAEASGKSEGK"
     gene            8818..9345
                     /locus_tag="I4U27_RS03060"
     CDS             8818..9345
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884603.1"
                     /locus_tag="I4U27_RS03060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VanZ family protein"
                     /protein_id="WP_014634995.1"
                     /transl_table=11
                     /translation="MFRLKTWVDKDGELTPKGRKLSRVLVYTYLLCLVLLCWTPQYGLV
                     EGVDTPGIQHFGRVVVLLTPFNSLTNFYQLDSLKEIVFVLGQNVTNIFLLSPLILGLLA
                     LYPRFRSWKKVLLATFVMSLTIEVGQVILDLLIDANRVFELDDLWTNTLGGLLALAAYR
                     LLVKLIQTHFKE"
     gene            9505..9894
                     /locus_tag="I4U27_RS03065"
     CDS             9505..9894
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014634994.1"
                     /locus_tag="I4U27_RS03065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_223896453.1"
                     /transl_table=11
                     /translation="MVKADTYQSGRDADIMRERGQVWNYSEAKREPQLANYNTDGRYLS
                     EATNFELYNFVREYKTSDEIRRIWNPKKDESVIHDKDSYSMDDGHKVYNFDSFAYQLPE
                     STDFGKLSYIGHFQLEDGTIYRYWK"
     gene            9958..11718
                     /locus_tag="I4U27_RS03070"
     CDS             9958..11718
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002891740.1"
                     /locus_tag="I4U27_RS03070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter transmembrane domain-containing
                     protein"
                     /protein_id="WP_060971665.1"
                     /transl_table=11
                     /translation="MSFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLIPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLVAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFKKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIENLLEQESDVQDPAHPLPSIENGRL
                     EYAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGQTGSGKTALVKLLLREHDVNQGAIYLN
                     GHNIRDYRLSDLRSLMGYVPQDQFLFASSILDNICFGNPDLSFDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILDPDILILDDSLSAVDAKTEYAIIDN
                     LKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHEDLLAKGGWYAKTYESQQL
                     EMEGGEEDDA"
     gene            11711..13456
                     /locus_tag="I4U27_RS03075"
     CDS             11711..13456
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621922.1"
                     /locus_tag="I4U27_RS03075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_195187973.1"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALAFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASLILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGILSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVVIIEKTRALLSDINAKLSESIEGIRIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSMSLDSLFLRPAMSLLKLLGYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRGTDAKVTEGNI
                     RFENVSFSYDGKHQILDSISFSVNKGETIAFVGSTGSGKSSIINVFMRFYEFQSGRVLL
                     DGVDIRDYSQAELRKNIGLVLQEPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYEAPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     AMEGE"
     misc_feature    complement(13516..13531)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            13617..13850
                     /locus_tag="I4U27_RS03080"
     CDS             13617..13850
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679948.1"
                     /locus_tag="I4U27_RS03080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Blp family class II bacteriocin"
                     /protein_id="WP_195187971.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.7e-17,
                     bitscore: 56.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQTMNNFETLDLETLANVEGGNRCKDLIFGGALTGAGAGFTGG
                     MAAFGVTAFPGAFVGAHVGAVAGGLACIGASF"
     gene            13887..14051
                     /locus_tag="I4U27_RS03085"
     CDS             13887..14051
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006531876.1"
                     /locus_tag="I4U27_RS03085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class IIb bacteriocin, lactobin A/cerein 7B
                     family"
                     /protein_id="WP_225791565.1"
                     /transl_table=11
                     /translation="MCDAELEIISGGGKVGAVIGGCLGGMLMAWAAGPVSAGGYTMICA
                     TSGLANAYF"
     gene            14334..14735
                     /locus_tag="I4U27_RS10350"
     CDS             14334..14735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014634989.1"
                     /locus_tag="I4U27_RS10350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048674851.1"
                     /transl_table=11
                     /translation="MKLKNVSSRVLRFSRVVTAVLAVFLISTSISLYKSKTSPEIWLAV
                     GALALVVIFVNGLLYHILKKRPDSVNPLTIRQSFIVFLVISFLVLCVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLAYLQVKKYFKR"
     misc_feature    complement(14924..14939)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            15019..15186
                     /locus_tag="I4U27_RS03090"
     CDS             15019..15186
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003093272.1"
                     /locus_tag="I4U27_RS03090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048674846.1"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIGMGLANLFRSLDAVHHTINLLGLTLLLYSL
                     LFKKWTQFKK"
     gene            15793..16209
                     /locus_tag="I4U27_RS03095"
     CDS             15793..16209
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004183358.1"
                     /locus_tag="I4U27_RS03095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048674843.1"
                     /transl_table=11
                     /translation="MVILQKFSSAVLRSLRVVSAILGVVIGNIALNTLSSQHPIWIWLP
                     LALLSIFLLVLPLLIKQELDRRPLEERQFTLKQIYAGMGLAHLAIILAGIYRLLTVRDA
                     EWRLIIIVVIVLDICLLAFLTPRVLKVIKQSERG"
     gene            16333..16713
                     /locus_tag="I4U27_RS03100"
     CDS             16333..16713
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002951783.1"
                     /locus_tag="I4U27_RS03100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048674841.1"
                     /transl_table=11
                     /translation="MSKNLRAITAIVLSQLLIEWMGFFLGIPLSKILVLTVLSSLAEIL
                     MHLFLIKKSKVTLGDKEIWHQYFLFFKKTLWLSILLVAILLFYTLTKSDSFMLYFYWHI
                     FVLFHCLGYIICLNNIKMNRKN"
     misc_feature    complement(18377..18391)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.81"
                     /tool="antismash"
ORIGIN
        1 gaacagattc ttgagatgct taaggggatg caaccatacc tggcaatgat tttcgttaat
       61 accaaggaac gtgcagacga tttgcacagc tacctagtgt caaatggtct taaggttgcc
      121 aaaattcatg gaggtattcc accacgtgag cgtaagcgta tcatgaatca agtcaagaag
      181 cttgattttg agtacattgt agcgactgac cttgcagcgc gtgggattga tattgaaggg
      241 gttagtcatg ttatcaacga tgctatccct caggatttgt ctttctttgt tcaccgtgta
      301 gggcgtacag gacgtaatgg tttgtcagga acagctatca ccctttatca accaagtgac
      361 gactcagata ttcgtgagct tgaaaagatg gggattacct ttgaccctaa agtctataag
      421 gacggcgagt ttcaagatac ttatgaccgt gaccgtcgtg ccaaccgtga aaaagcctat
      481 caaaaacttg atacggaaat gatcggtttg gttaagaaga aaaagaaaaa aatcaagcct
      541 ggctacaaga agaaaattca gtggaaggtt gacgaaaaac gcaaacgtga gcgtcgtgcg
      601 gctaaccgtg ctaaggggcg tgctgagcgt aaagctaaga agcaaagttt ctaagtattg
      661 gcttctaggt gagagcaaat tttaatttaa aaattcaaga ggttgaaacc aaagtgtttc
      721 agcttttttg attattatca aactttttgg aaactcaaaa gaccttattt agtttgaaga
      781 tatatttttc ttttgagcct aaggtctcaa aacttcccaa cgcttatgac tacaaagttt
      841 taggtgtcat tatcacagcg acaagtctca gtatatgctc actacactcg caaaataatt
      901 ggctgtctta aggcctgaaa atgtaatgaa taaatagttt tttactattt actacaaaaa
      961 aaccaacaaa atgatacaaa agaaagttga ttttgataat ttaagctaaa ctaaaaacat
     1021 atagaatgcc ttattaataa tagttgacac attttaaata gctttattaa agccattttt
     1081 aaaaagattt gattctataa cttttatgga aaaagggaaa attattgcaa aagacaagta
     1141 tgaattatta cttgaaactt gtgataattt caatgatttt ttaatgtata ctgcaactga
     1201 tggaggtaat caccatgaat acaatattac gagcctgtca tttgaataaa tcatttggaa
     1261 aacaagaggt attaaccgat ctcaatttcg aaattcaaag aggtgacatt gttggcttaa
     1321 ttgggaagaa tggctgtgga aagactactt taatgaagat gatcttagga cttactccac
     1381 gcacaaaagg taaaattcaa tttaaagggg attcagaata taatactaaa agaaatagtt
     1441 taaataaaat cggttttctt ctagattgta aattatttga agatttttct gcatatgata
     1501 atttgaaatt attctctatg tattcttcat catttgataa gagtggacta gataaacgga
     1561 ttaataagtt gttaaaattt gtgggtttag atagtagcaa aaaactagta aaatcttact
     1621 cgtttggcat gaagcagaga ttggggttgg cattggcctt gttagatgac cctgagtttc
     1681 tgattctaga tgaacctttt gtgggtttag atcctgcagg agttagagtt cttttagact
     1741 atattgtgaa gttacgtcgt gaaaaaaggg ttacaatatt aatctcatca catcagttac
     1801 atgaaattga agaaatttgt gattatttcc tatttataaa tggaaagagt attgaaacac
     1861 atactaaact aggaaaaaat aaaataatta ttactttaga atatgcagtg ccggagttgg
     1921 aacaaagtct tagtaaatta gttaccctaa aagaaggtca gataatctta ccacatgata
     1981 tgatgttatt gaattcgatc ctgaggctca tttataaata taattgtgag ataaaagaaa
     2041 tcacggtgag tgactctatt gaagaattat ttagggggtg aaaaaatgca atcaatcgtt
     2101 ttagcagaac tatataaatt attgaaacgg aaaaatttta ttatattagc tatactatca
     2161 ttgtggtctt tgatttatgg ttttggtgcc tttttacatt gggactttgt aaaaataggg
     2221 gctaaattag atttagttac ctttatcacc acgatgtgga catttttatt aatattaact
     2281 atcccgttat tattaatttt atatacttct tcctttattt taggaggaga gattcaagga
     2341 ggacaaattt tattagaggt aaatagagtc actagtaaga aaatattgat agtctctaag
     2401 tatattgttg ttatcctatc aatattattt ttatatatct taaattgctt gacgtcgtta
     2461 gtcacttata tttgctttat atctcatact gagttcggtt atacacgatt ttgggagcta
     2521 catgctacaa atgtacaatc aatagtagtt agtttagtga atttaggatt tattattttg
     2581 cttgctagca ttgcttttta tctatcacta aatatttcgg caataatggc ttcgtttgca
     2641 agtctaggtg tttacttttt atgtcaactt ctatcaaata ttactatgat ttctaaattt
     2701 attcctggat atttttttgt tgtgcctaat tatcatttta caattggatt atctctaatt
     2761 catttactaa gttatttttt gctttgtata ctgttattga ttgctaccat gaaagggttt
     2821 gaaagtaagg cgttgtgaat gatataatat tagaaaaagg aatttataga gacagatgta
     2881 taaagtagca atttgtgacg atgatagctt acaagtgagt aatttagaaa ctcatatttc
     2941 agaatacttt gatgaaatca atgtccaata tgaaattgat ggctattaca aaggagaccg
     3001 tatggtaaat accatgagtg gacaaattga caactatcac ttgatatttt tagatattga
     3061 aatggagggg ctaaatggta tagagactgc taagttattg aggaatattg ataaaaattt
     3121 tatactcatt tttgtcacaa gctttgagca atatgcttta gaaagttttg aagtctctcc
     3181 atttcgttat ctaataaaac ctgtatctat tgaaaaattg agagaggttc tcagggatgt
     3241 tctggtagaa ttaactgcaa aacaaaaatt tatgttttat cagataggta cggaacattt
     3301 ccaaatgagc ttagataata ttgtgtgtct atattctgag tttggtagga aaatccacct
     3361 tgaattagtt agtggtagtg atacatcgtt ttacgggagg atatcagcaa ttgaaaaaga
     3421 attaccttca actcattttg ttagggttaa tagtggaaca atgattaatt taaaccatat
     3481 atcctcattt aatcagaatg atgtaactat gataaatggt aattgtattg ctattagtag
     3541 aagtcgtaag aaagccgtga gaacagcata tagccatttt attgagagga gtttcggttt
     3601 atgattgatg tatataaatc agtggggcta ctctctcttt ttttattcca aagttttgtt
     3661 gtttggtttt atttacaaca cttttttgtg atcagaattt ccaaaagcaa gttttattgt
     3721 ttgatcttat ttgtttattt tattggccac gcatcaataa caataaatca taatacattg
     3781 ttagatttta aaatcttatc tttgctatta actttcctga ttcttttcct ctttttatcg
     3841 ggagatgtta tgaaaaaggt atttcattat ttattcctga ttttttggtt tttgattcaa
     3901 gaagatatag caatattgct attacatcaa gttcaacaaa ctaaagaaat cgtaattttt
     3961 ttcgcccaat tctttttgat gttgttaacg cttttatttg tgttaggatt aaaacacttt
     4021 aaaatagata atctatttga gctgaacaaa atagaatacg gtatcttatc gttgcctcca
     4081 tttttgtcta ttattttact gttatataag atgccactac ctttaagtcg agttttgata
     4141 tttgatagtt atttattatt gataaacatt gttataattg tgctttacaa ttatttgagt
     4201 gaaaaaaatt ataatattat caaaggcaaa attgcttttg atgaaaatag catgactagt
     4261 gaaattattc aacaagaaga agaactagca attctcagac atgatttaaa aaatattgtt
     4321 tcctcaatag atttttatgc agatagtaat gattttggaa acatcaaagc aataactcga
     4381 gagatactgg gacaggaggt ttttaatcgc aagattacag gatgtatacc aattgacgct
     4441 atattaaatc aaaaaatatc taaaatgaaa aaagatggag tccagtttca tctagattta
     4501 caaatcccct ataacttaga tataagttcg attgctatag attcttgcgc tattctcgga
     4561 aatattatcg acaatgcaat agaggagatt gaacgtaatg gattaacgaa tccaatcgaa
     4621 atagtattac gttttaagaa taataaacta gtctttaaag tggcgaatcc tatacttact
     4681 tctgaaatag atatcaatta caacggaatg aaatctataa aattacctaa tagacgtggt
     4741 ctaggaataa aaagtagtta tgatagaatc atgaaactga aaggacattt gaatattaat
     4801 atacagtcaa atcaatttgt ggtactagtt gttattcctt taaaaataaa ataatttgga
     4861 agtcctaagg tctaagttga gtcaactctc aaaatcaggt agtgacattt atgtcactac
     4921 ttttttgttg gctttctatc tataatacaa tcatagcttt tgagaaaagg ctaaaaaata
     4981 ttttaaagga ggttgtttta atgacgacac aaatcattaa caattttaac tcacttaatt
     5041 ccgaagatct ttctactgtt aagggtggag catgtagttt ttggggagct acagctgccg
     5101 taggcgtcgg ggctgttgga ggagccatta aaggtggtat tcaaacaggt acttggcaag
     5161 gtgcagcctt aaagggtatt ggttatggta ttaaagatgg gattacttat ggacttattt
     5221 gtcgttatta ggcgattact gagtcaattt tttggccaaa tagtacttgc tctcctaatt
     5281 tatgggctta tattctttgc ttggcaacac tttagaggag aaattttctc aattgtatgc
     5341 atctatgtca gtatatccct agcagatgac gtctatcatc tcgcagaaga atatgttaaa
     5401 aagaaagtta actaggaata cgttcctgtt tgaaaaatag catgtaaaaa cttggcagaa
     5461 tgattgtcaa gtttttttat agcaaaagtg ctacaatagg agtcatgaaa gacacgattc
     5521 gaattcttca tatcaatgat ttacactctc attttgaaca gtatccacaa ctcaagcgag
     5581 ctgtggatga tttgagtcag acggatagag agttgatcaa ggtagatctt ggggataatg
     5641 tggataagtc ccatccccta tctgatgcga ccgctgggcg ttttaatgta gccctgatga
     5701 atgagttggg gatagactat gcgactattg gaaataatga ggggataggt ctggccaagg
     5761 aggagctaga ctgtctttat gagcaggcta agtttcagcc gatcatagga aatctcaagg
     5821 atgaggggag acaacctgaa tgggccaagc cctatattat ccacaaaact aaggcaggta
     5881 caaacattgc ttttttggcc tatacctttc catattacat cacctatgct cccaacggtt
     5941 ggcaggtgtt agagcctatg gctaggttgg aagaggattt gggtcgtcct gaggtaaggg
     6001 atgcagatat agtcgtcgtt cttagccatc tgggtgtacg ttatgatgag cagattgcag
     6061 agacttatcc acaggtaaat cttgtcatcg gaagccacac gcatcacctt tttgaagagg
     6121 gcaaattagt caatgagacc tatttagcag ctgctgacag atatggttat tatcttggct
     6181 gtattgacct tactgtggaa aatgggcgat tgatagaatg tcagattgag gctatcccca
     6241 ccaagtccta catcttggat ttagacaagg aggacgaagt ctttatcaag gctatgcgtg
     6301 aggaaggcca tcgccgttta gctcagaaaa aagtagctaa tctaggtcga gaactagatt
     6361 ttgatgagac ctgtcaattg gttttacagg ctgtttgtca ggagaccgat agccaattaa
     6421 cgcttttaaa tactggactt atcatgaaaa cactaggtcc tcaagtgacc atggcagacc
     6481 tgcaagaagc ccttcctcac cagatgcgga tggcacgtct agtcgtgaca ggacaagagc
     6541 tcaaagaaat ctgtcaggaa gtttttacta aggctgaact ccttaaaaat caagctatta
     6601 aaggtatggg atttagaggg aagatatttg gtgaagtaat cacagggaat tttgcttaca
     6661 aaaacggtaa tttgttgtat aatagaaggg ttgtagattc caatgagaag tttagtttgg
     6721 tccttgtgga ccagtactac tttgcttctt actttcctac aattaaggaa aaggaagtta
     6781 ctcttctttt tccagatttg ttaagggaac ttgtggccaa gtatttagga aaaaatggtg
     6841 ccaattggga taagatatag agacattatt acagcatcag gatagaaaat aagagagagc
     6901 agaaaggatg gcacatgcgt aaagaaatct tgccagaaat gtttaattat aataaatatc
     6961 cagggccaga ctttgtgtat gtggctgatc ttctgaaatc agatgcctgt cagtttacag
     7021 ttcttgaaaa tcacaaggat gctttagacg ctacccgctt tgggcaacgt ttttctgaaa
     7081 tcatgctcaa gtatgattat atcgttgggg actggtctaa tgatcagctt cgtcttaagg
     7141 gattttacga ggacgagcgc cctaatacgc gtaagacaga ccgcattagc cgattgtcag
     7201 agtatttgcg tgaatactgt gcctttggtt gcgcctactt tattttgaaa aatgaagagc
     7261 cgcaattaat cgtctttgaa gaggagacgg agcctcgtcg caagcgccgt cgttctaata
     7321 atcgtcgtaa ttcttctcag gaatctagag atagagagcg caatgcttct caaaagaata
     7381 aggggcaaaa agcttctgct aagcaaaagc cagacaagtc caaacgaaga gatagggatc
     7441 aagagggtcc aagctttgag aaaatcaagc gtcgccctaa gttcaaatct agatccgagg
     7501 acggtggtcg tgagcgtaag cctaacttca agaagagtca gaagcaagct ccaaaatcta
     7561 aaggtcaaaa caccccatcg aagaaacaaa gccagaccaa gtcagatggt cagcatttca
     7621 caatcagaaa aaaaggaaat taaactatgt cagaagtaac aacacaagca aaaccagaac
     7681 gccgtaaacg tcagaagtta gaggatatgg aaggctacaa accttctatt tatggtctta
     7741 ctcgtgacga gttgattgat tgggctatgg aacacggtga aaagaaattc cgtgctactc
     7801 aaatttggga ttggctctac aagaagcgtg tgcaatcttt cgaagaaatg accaacattt
     7861 ctaaggattt cattgctaaa ttgaatgaga atttctgtgt gaacccattg aaacaacgta
     7921 tcgttcaaga atctaaagat ggtaccgtta aatatctttt tgaattgcca gatggtatgt
     7981 tgattgagac ggttttgatg cgtcaacact atggtttgtc tgtctgtgtg acaactcagg
     8041 ttggatgtaa catcggttgt actttctgtg ccagtggttt gattaagaaa caacgtgact
     8101 tgactgctgg tgagattgtg gcacaaatca tgttggtaca aaaatacttt gacgatcgtg
     8161 gcgacggtga acgtgtaagc cacgtggttg ttatgggtat cggtgagcca tttgataact
     8221 atgacaatgt gcttcgtttc ttgcgtacca ttaacaatga taatggtctt gccattggag
     8281 cgcgtcacat taccgtatca acatctggtt tggcaccaaa aatcaaggaa tttgctaacg
     8341 aaggtgttca agttaacctt gccgtatcac ttcacgcgcc taacaatgac cttcgttcaa
     8401 gcatcatgcg tatcaaccgc tcattcccac ttgaaaaact ctttgaagct atcgagtatt
     8461 acatccaaac aaccaaccgt cgtgtaactt ttgagtatat catgcttaat gaggtcaatg
     8521 accatcctga aaatgcacaa gagttggctg atttgactaa gaaaatccgt aagttgtcat
     8581 acatcaactt gattccatat aacccagtat cagagcacga tcaatatagc cgttcaacta
     8641 aagaacgtgt ggcggccttc tacgatgtgc ttaagaaaaa tggggttaac tgtgtggttc
     8701 gtcaagagca cggtacagat atcgatgctg cttgtggaca attgcgttca aacactatga
     8761 aacgcgaccg tcaaaaagca gtggcagaag cttctggtaa atcagaaggt aagtaagatg
     8821 tttcggctta agacttgggt agataaggat ggagaactaa caccaaaagg aagaaagcta
     8881 agccgagttt tggtctatac ttatctcctt tgtttagtgc tcctgtgttg gacaccccag
     8941 tacgggctag ttgaaggtgt tgacacccct ggtattcaac attttggtcg tgttgtggtc
     9001 ctattaaccc cattcaatag tttgaccaac ttttatcagc tggatagtct taaggagatt
     9061 gtctttgtcc ttgggcaaaa tgtgaccaac attttcttac tgagtccgct gattttaggg
     9121 cttttagcct tgtaccccag attcaggtct tggaaaaagg tccttttagc gacctttgtc
     9181 atgtctttga cgattgaggt tggacaagtc attctagacc ttctcattga tgctaatcgt
     9241 gtctttgagt tagatgattt atggaccaat actttaggag gtttgctggc attagctgcc
     9301 taccgcctcc ttgtgaaact gattcaaacg cattttaaag agtaaaaaac ctgggagctt
     9361 acgcgtctca ggtttcactt attttctatc atacaaatac aacacattca aaagagggaa
     9421 aaatgaataa acacgtttgg agaaataatg aaacatttaa tgatgacagt agtcaccgta
     9481 ttaacgttag gagtaacaat gacgatggtt aaggcagata cctatcaaag tggccgtgat
     9541 gccgatatca tgcgagaaag aggacaggtt tggaattatt ctgaggctaa gagagagcct
     9601 caattagcta actacaacac cgatggtcgc tatctcagtg aggcaactaa ctttgaattg
     9661 tacaattttg tcagagagta taagacatct gatgaaatca gacgcatttg gaaccctaag
     9721 aaagatgaat ccgttatcca tgataaggat agctactcta tggatgatgg gcacaaggtc
     9781 tataattttg attcctttgc ttatcaattg ccagagtcta ctgattttgg gaagttatct
     9841 tatattggtc actttcagtt agaagatggc acaatctatc gctattggaa gtaaccttat
     9901 catacgagac ttatacgagg tctattatta accatttgta aggataggag gagtaacttg
     9961 tcttttaaag aatcaatcat tgcaaaactt tggtggtttt tcaagttaga aaaacgccgg
    10021 tatattgtcg ggattttggc actgagtctg gtttcggttc tcaatctgat tcctcctatg
    10081 gttatggggc gggtcattga tgctatcaca tcgggaaaat tgaccaatca gatcttgctt
    10141 ctgaatctcg tatatttgct tttggcagct ctggggatgt actatttgcg ctatgtttgg
    10201 cgcatgtata tcttggcgac ttcttatcgc ttaggccaga ttatgcgttc acgccttttt
    10261 gagcatttta ctaagatgtc gccttctttt tatcaaaagt accgaactgg ggacctcatg
    10321 gcccatgcaa ccaatgatat caactcttta acccgcttgg ctggcggggg cgtcatgtca
    10381 gccgtggatg cctctatcac agccttggta accctaatca ccatgttttt cagcatttcc
    10441 tggcagatga cactggtggc tgtcttaccc ctccccttca tggcttttgc gactagtcgt
    10501 ttaggacgca agacccataa agcttttgga gaatcccagg cagccttttc agaacttaat
    10561 aataaggtcc aagagtcggt atcaggtatc aaggtaacca agtcttttgg ctatcaggag
    10621 gctgagcttc agtccttcca agagaccaat aagatgacct ttaaaaagaa tatgcatacc
    10681 atgaagtatg atagcctttt tgatcctttg gtcttactct ttgttggctc atcctatgtt
    10741 ttgacccttc ttgtcggtgc ctttatgatt caggctggtc agataacggt cggaaatttg
    10801 gtaaccttca ttacctattt ggacatgctg gtttggcctc taatggccat tggcttcctc
    10861 tttaatatca cacagagagg aaatgtgtcc taccaacgta ttgaaaatct tctggagcag
    10921 gaatcagatg ttcaagatcc tgcgcaccct ctcccaagta ttgaaaatgg tcgcttagaa
    10981 tatgcgattg accgctttgc ctttgaggat gaggatactt tgagagatat tcatttcacc
    11041 ttggacaagg ggcaaaccct tggtttggtt ggacagactg gctcaggaaa gacggccctt
    11101 gtcaagttgc tcttgcggga gcacgatgtt aatcaaggag ccatctattt gaatggtcat
    11161 aacatccgag attatcgcct atcagacttg cgtagcttga tgggctatgt tcctcaagac
    11221 cagtttctct ttgccagctc cattttagac aatatctgct ttggtaatcc ggatctctcc
    11281 tttgacaagg tagaagaagc gactaagtta gctcaagttt atgatgacat caaggatatg
    11341 cctgaaggct ttgaaacaat cattggtgaa aagggtgtca gcctatcagg cggtcaaaaa
    11401 caacgtctgg ccatgagtcg ggccatgatt ttggatccag atattttgat tttggacgac
    11461 tccctatctg cggttgatgc caagacagaa tatgctatta ttgacaatct caaacatacc
    11521 cgcaaggaca agacaactat cattaccgcc catcgtctga gtgcggtggt gcacgctgac
    11581 cttatcttag tcatgcagga tggtcgtatc attgaacgtg gccgtcatga ggatttgcta
    11641 gctaagggtg gttggtatgc caagacctat gagtctcaac agttagaaat ggaaggagga
    11701 gaagaagatg atgcctaatc aaaaccaatg gtctgtgttt aagcgtctct tgacctatct
    11761 caagccttac aaattcttga cctttctagc tttagccttc ctcttgtcca caacggttat
    11821 caagagtatt attccccttg tggcctctta ttttattgac cactatcttc atgatatgaa
    11881 tcaggcggca agtttaattc tgattggtta ctatggtctt tatcttttgc agacactagt
    11941 tcagtatttg ggaaatctct tttttgcgcg tgtgtcctac agcattgtca gggatattcg
    12001 ccgagatgcc tttgccaata tggagaaact aggcatgtct tactttgaca aaactccagc
    12061 aggctctatc gtttcccgct tgaccaatga tacagagact attagtgaga tgttctcagg
    12121 gattctgtct agctttattt cggctatctt tatatttgtt accacccttt acaccatgat
    12181 gatcttggac attcgtctga ccgggcttat tgtgctcttt cttcctctga ttgttctttt
    12241 ggttaatctc taccgcaaaa aatcagtggt catcattgaa aagaccagag ccttgctttc
    12301 agatataaat gccaaactgt cagagagtat cgaagggatt cgcatcattc aggcctttaa
    12361 ccaagagaaa cgcctcaaaa aagagtttga tgccattaat gaggaacacc tgatttacgc
    12421 cagccgttcc atgtcactgg attctctctt tctacgccca gccatgagtt tactgaagct
    12481 cctgggctat gctgttctca tggcctactt tggctaccga ggtatctatt tgggcatcac
    12541 agcggggacc atgtatgcct ttatccagta cattaaccgc ctctttgatc ccttgattga
    12601 agtgacacaa aacttctcaa ccttgcaaac ctcgatggtc tcagcaggtc gggtcttcgc
    12661 cttgatcgac gagcgcacct atgaacctga gcagagaggc acagatgcca aggttactga
    12721 ggggaatatt cgctttgaaa atgtctcctt ctcctatgat ggcaagcacc agattttaga
    12781 tagtatttcc ttctctgtca ataaaggaga aaccatcgcc tttgtcggtt ctacaggttc
    12841 cggaaaatcc tctattatca atgtctttat gcgtttctat gagttccaat caggacgagt
    12901 tcttcttgac ggtgtggata ttcgcgatta tagtcaggca gagctacgta agaacattgg
    12961 tcttgtcctt caggaaccct ttctctatca tggtacaatc aaatccaata ttgccatgta
    13021 tcaagattta actgatgaag aaatcaaagc cgctgctgag tttgtggatg ccaaccactt
    13081 tatcgacaaa cttccagaag gttatgaagc tccagtttcc gaacgaggtt caagtttttc
    13141 aaccggtcaa cgtcagcttc tagcctttgc taggaccgtt gctagtcagc ctaaaatctt
    13201 gattttggat gaagcgacag ccaatattga ttcggagaca gaggctattg tccaaaactc
    13261 tctagcaaaa atgcgtcaag gacgtacaac cattgccatt gcccatcgtc tatcgactat
    13321 ccaagatgcc aactgcatct atgtcttaga caagggccgc atcatcgaac acggtagcca
    13381 tgaggaactc ctagccctcg gtggtaccta tcataagatg tacagcctac aagcaggtgc
    13441 aatggaagga gagtaagtta gtctagacca tagattctat attcgaaaag atttcttaaa
    13501 aatcaaaatc gagtggtgac atttatgtca ctactttttt gttgtcttcc accctataat
    13561 aaaaccatag cttgagagaa aaaagctaaa aaataatatt ttaggaggtt gttagaatga
    13621 caacacaaac aatgaacaat tttgaaacac tcgatctcga gacacttgca aacgttgaag
    13681 gtggaaatag atgtaaagat ttaatctttg gaggagcttt aactggcgca ggtgctggat
    13741 ttacaggtgg tatggcagca tttggtgtta cagcatttcc aggagcattt gtaggagcac
    13801 atgttggagc agttgctggt gggctagcat gtatcggagc gagcttttag agaggttaaa
    13861 aaatgaatgt gactaagtat aataagatgt gcgatgctga gctagaaatt atttctggtg
    13921 gtgggaaagt tggagcagta attggtggct gtctaggtgg tatgctcatg gcatgggcag
    13981 caggacctgt ttccgcaggg ggttatacta tgatatgtgc tacttcgggg cttgcaaatg
    14041 cttatttttg atgttcccga agtaaaatta ttcttgctga taatagcgga gattatatta
    14101 tatttgattg catatcttag taatagaaaa aacaaagata tgtatattcg cctatttaaa
    14161 gtatcagtac taatgacgct actgtattac atctccagta gaatgtaatc gctaaggtct
    14221 tttttgagat cttacagcag tataaaaaaa tacagaaagg aatagagttt aatgtaatag
    14281 cttattcagt ttacaagact gactgaggtt attcataatt taggtgtttt atcatgaagt
    14341 taaagaatgt tagttcgaga gtattgcgat tttctagggt cgtcactgct gtactggcag
    14401 ttttccttat aagtaccagt atttctctct acaaaagcaa gacctctcca gagatttggt
    14461 tagcagtcgg agcactagct ttagtagtca tttttgtaaa tgggctgctc taccatattc
    14521 ttaagaagcg tccagattca gtgaatccgt taacaatacg gcagtccttc attgtctttc
    14581 tggtcatctc atttctagtg ctttgtgtag agttttacac attacttaca ttcagtgata
    14641 ccacagaccg tatagtacta gccgtattaa tgcttttgtt aatcctctgt gattttctag
    14701 cttacttgca agtcaaaaaa tattttaaaa gataaaaggt atctataatc atgactaaaa
    14761 aacacctagt atctctaatg atgtctatgg gcttcatcct tgttgcctta cataacttgg
    14821 gagaaaaact gaattttgga cttcaatgcc taaatattat tgggttatgt ctttttctct
    14881 ttcttatgtg tacgattatc aaggatataa ggtcagacaa gtagtgacat ttatgtcact
    14941 acttttttat cggcttccaa tctataataa aaatcatagc tttgcacaga aagctaaaaa
    15001 cactttaagg agaaaagtat gttcaaaaac tcaaaaccgt atttactggc taccattctc
    15061 atcggaatgg gcctcgctaa tctatttaga agtttggatg cagtccacca taccattaac
    15121 ttgttggggc taaccttgct tctttatagt ctgcttttta aaaaatggac acaatttaag
    15181 aaataatgtt gagtcctaga taatccgatt acttgtgttt tgtcactatc ttgagaggaa
    15241 aagactctaa agctcactct aaccccacca ttcagaaaat atagtaaccg tttgtgacat
    15301 tattcaattt acgttgcata aaagtgttat aataagaaag tgattaatga aacatgtgaa
    15361 aattagagtg aatttccaat gtttgaagga tattcttcta tcgtatagac aaaacttgca
    15421 gggtctgggt cttcaaaaaa tgtcatgaaa ggaggattac tattggaaca atttgttatt
    15481 tctagaaaat atattaaatt tatcgtgcaa gttattttgg ctgtctgtat tcaatgtgtg
    15541 ataacatttt tctggcatca agaaagaaca tttttatttt ataccttgtc actttatgtt
    15601 tcttcatcgc tctctgatga tcttagtcag ctgatttgta gaaatgagaa gtgatgtcgt
    15661 tactctaatc tgtcacgatt aatgtgatat ttacgaggtt ttagctattc tagattcaga
    15721 aataatagcc aatcatttct atgataatac cttataattt gtttaaatag tcctagtaaa
    15781 aaaggagtta aaatggtgat attacaaaaa tttagttctg ctgtgttacg ttcgttacgt
    15841 gtcgtatcag caatcctagg agtagtcatt gggaatatag ctttaaatac tctatctagt
    15901 cagcatccaa tctggatttg gctacctctg gcattgctat caatcttttt acttgtgttg
    15961 cccctgttga ttaagcaaga gcttgaccgt cgtccacttg aagaacgaca gtttactctt
    16021 aaacaaattt acgctggtat gggcttggcg catttggcta taatcttagc tggtatttat
    16081 cgtttgctga cggtgagaga tgccgaatgg cgtctaatca ttattgttgt gattgttttg
    16141 gatatttgtt tgctagcttt tctgacacct agagtgctta aagttattaa acaaagtgaa
    16201 cgaggctaga attcagttta tgatagacac gcctataaaa attgcgatgc tgtaagttct
    16261 tatctatgct ttggtaactt tctaggtgtt gtgaaaactt tctgtttgag agaactgtga
    16321 ggtttaagtt ttatgtcaaa aaatctacgt gccattacgg ccattgtttt gtcccaattg
    16381 cttattgagt ggatgggatt ctttttaggt attcctctaa gtaagattct ggttttaaca
    16441 gtacttagca gtctagcaga gattttgatg catcttttcc taatcaaaaa atctaaagtt
    16501 actttgggcg ataaagagat atggcatcaa tactttttat tctttaagaa gacgctgtgg
    16561 ctctccattt tgttagttgc cattttactt ttttatacgc tgactaaatc tgatagcttt
    16621 atgctttatt tttactggca tatctttgtg ttgttccact gtcttggcta catcatttgt
    16681 ttaaataaca ttaaaatgaa tcgtaaaaat tgaagactaa atcttgttta tttccacaca
    16741 ataaaaaaat cccatgggag ttctcatcct atgggatttt tgcgataaag actaataagg
    16801 caatgtcatc tgactttggc ttaggtccac agttaattcg tagtcactat tgtcacgaat
    16861 ggtgtgctca aagtctgtgg tatagagaac aagtcggagt ttgtcgccct tgttgagttt
    16921 gtagatggtt ggttgcaaat ccaaaccgat agtcatccat tcatttggag tgacatcctc
    16981 aatggtgagg aggtctttac gattttgcag gttaaggtgt cccttggtaa tgacacggta
    17041 ttttgcctgc ttgaatggca attcacgtaa ggcttcttcc ttgaagagac ggccgttatc
    17101 tagattcatg cgtttgagtg cgggaatagg tgcgagatac ttcttgtcac ccatttctag
    17161 aacttgggcc gaaatgagac cacggtttgt gttagactta accttgagct ctaggtggac
    17221 acgaccattg atttggatat cttggtccag ttcaaagtcc aaggtaatgg cattggcttt
    17281 gtctgcaaag aggtcatcct tgaagctttg gtaagcttta ccatatttgg tgaaggtttc
    17341 ctcttcgtaa tggttagcga tgctagcttc agcctcacca agctgaatgg ttttcccatt
    17401 gttgtgtcca aagttatcga gaacttccca ggtctgttca gactggttgt tttgccagat
    17461 aacagtaggc agtgtgtagc cattctccaa accaaggagt ttctgacaaa tcaaggcgtt
    17521 catgctttct cggaagtcaa tggactgcca agcattcatg taaacgtggg caccattgtg
    17581 gaagaagagg tgtttgtcaa gagagtctgg aagagcattg aacatttgat agacgttaat
    17641 cggtttgaca ttccagtctt ggctaccatg tgtaaagaca acagtggctt tgacacggtc
    17701 tgcgaactgc acatagttac ggtcatgcca gaattggcta tagtccccat gcttacgatc
    17761 aatagctgtg cttagctctt tgaggtaggc ctcgtattct ttttggtggc gtaggtattc
    17821 tccagctaat agggcacgag aataggtaaa ttcagtcaag gtgtcaagat cttcaccagg
    17881 gtagcctcca ggactgacta ggagtccatt ttcacgatag tagtcgtacc aagatgaaat
    17941 acccgcttca gcaataacca tctccaaacc gtccacacca gttgtagcaa gggcgttgga
    18001 catggtacct aagtatgaaa gtccggtagt agtcacctta ccagaagccc aatctgcagt
    18061 gattgtatgc tgtctactac gactagtaaa ggcgcgtgca cgaccattga gccagtcgat
    18121 gacagcttta taggccagaa cttgttgata gtctccagag gtcatgaagc cttcagaatt
    18181 gaaagtaccg acacccgata catagataga agccacacca cgagccaaca tgtaatcgtt
    18241 aagcgtgtag gtatctgtgt gagcaaaacg ctcctgagcc tttgtgacag gattgatagg
    18301 cgtaaggtct gcctctggtg tcttgatttc tggttggcta agggagattt cacctgctgg
    18361 tttgacgagt aaatctccct ccatcttgtg ggtaagctta tctgaagcag gctcgttagt
    18421 cccttgttga taagggcttg cggtcatcat ggctggaacc gggaagtcca catcaggacg
    18481 taagatagtc accttgacca agtctaactg cccatcttta tcggtatcta caggtgtttc
    18541 gacataaacc acctcacggt gaagctgatt agtgtcaaat gttgccaagc tcttaccatt
    18601 aaagaagacg tagttattac ttgcagggat taaatcctga gctactaact gatcaattaa
    18661 ggtattgcca gactgtgtgc gtgttgctag caattgatgg aggttattaa ggctaccatc
    18721 aaaagtaatt gggaaagcca tttcctctag gaaagcaaca ctatctgtaa agtctacatt
    18781 agggacaaat cctagcattt gaagagctac caaaccaaag acgtcagcag tcaaaggacg
    18841 gtctgattgg
//
