LOCUS       NZ_JADPFA010000001     24217 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptococcus salivarius strain D43t1_170807_H4
            NODE_1_length_499016_cov_26.3491, whole genome shotgun sequence.
ACCESSION   NZ_JADPFA010000001
VERSION     NZ_JADPFA010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus salivarius
  ORGANISM  Streptococcus salivarius
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 499016)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 499016)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 27.95x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 10:18:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,053
            CDSs (total)                      :: 2,002
            Genes (coding)                    :: 1,964
            CDSs (with protein)               :: 1,964
            Genes (RNA)                       :: 51
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 38
            CDSs (without protein)            :: 38
            Pseudo Genes (ambiguous residues) :: 0 of 38
            Pseudo Genes (frameshifted)       :: 13 of 38
            Pseudo Genes (incomplete)         :: 30 of 38
            Pseudo Genes (internal stop)      :: 9 of 38
            Pseudo Genes (multiple problems)  :: 12 of 38
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:50:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 80008
            Orig. end                         :: 104225
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADPFA010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24217
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..24217
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24217
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14217](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14217
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(6..19)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.75"
                     /tool="antismash"
     gene            499..3117
                     /gene="alaS"
                     /locus_tag="I4U27_RS00410"
     CDS             499..3117
                     /EC_number="6.1.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004813 - alanine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006419 - alanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alaS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002261891.1"
                     /locus_tag="I4U27_RS00410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alanine--tRNA ligase"
                     /protein_id="WP_195914433.1"
                     /transl_table=11
                     /translation="MKQLTSAQIRQMWLDFWKSKGHAVEPSANLVPVNDPTLLWINSGV
                     ATLKKYFDGSVIPENPRITNSQKAIRTNDIENVGKTARHHTMFEMLGNFSVGDYFRDEA
                     IEWGYELLTSPEWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLIPIEDNFWEIGAG
                     PSGPDTEIFFDRGEDFDPDNIGIRLLEEDIENDRYIEIWNIVLSQFNADPAVPRSEYKE
                     LPNKNIDTGAGLERLVAVMQGAKTNFETDLFMPIIREIEKMSGKTYDPDGDTMSFKVIA
                     DHIRSLAFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGISDAFLYKLVPTVGQIMES
                     YYPEVLEKKDFIEKIVKREEETFARTIDAGSSMLDELLANLKKSGKDTLEGKDIFKLYD
                     TYGFPVELTEELAEDEGFKIDHEGFKAAMKEQQERARASVVKGGSMGMQNETLANITEP
                     SEFLYEAETAESRLSVIVADDARHDSVNSGQALLVFEQTPFYAEMGGQVADHGTISDAA
                     GTVVARVVDVQRAPNGQALHTVEVEGELVVGANYKLEIDHTRRHRVMKNHTATHLLHAA
                     LHNIVGDHAVQAGSLNEQEFLRFDFTHFEAVTPEELRAIEEQVNEEIWKATPVTTIETD
                     IDTAKSMGAMALFGEKYGKNVRVVSIGDYSVELCGGTHVANTAEIGMFKIVKEEGIGSG
                     TRRILAVTSREAYLAYREEEDALKAIAATLKAPQLKEVPNKVASLQEQLHALQKENAAL
                     KEKAAAAAAGDVFKDVKEAKGVRYIASQVEVSDAGALRTFADQWKQADYSDVLVLAAHI
                     GEKVNVLVASKSKDVHAGNVIKVLAPIVSGRGGGKPDMAMAGGSDANGIQDLLSAVAEQ
                     L"
     gene            3294..5849
                     /locus_tag="I4U27_RS00415"
     CDS             3294..5849
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014633990.1"
                     /locus_tag="I4U27_RS00415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SH3 domain-containing protein"
                     /protein_id="WP_195914434.1"
                     /transl_table=11
                     /translation="MRKAYVVKERQRYSIRKYSFGAASVLIGASLMLGGHALAQEQANS
                     TSTSKDYEVFVNNSEPLQIDQATSEAVTDVLNQPASRSEAPRPKLASSEVASSEANSVV
                     ASEAASLEVPAEVAHSASAVATVSRSEVASPRSEVSSVASSEAVSDTNRSATSEVAEAR
                     VTDREAVDTPQPGVDGPVTADGSLDIPSNGTYYFRRTTEIRTAPIMDIKPTFVFSAGDH
                     VIYDKVLKRDNHQWISYIGYDYERYYADIAALKAENTSSNTEATRDETIPERGTYYFTK
                     PADVKNQPSLTAKTEFNFDPGMSVNYDRSLLADNHRWISYVSYNGTRRYVDLGAAAEAV
                     AKPRGDIAIESHDNGDFSVVISNVLDQNGVLGVSVPIWSEKNGQDDIIWYNATRLNNGN
                     YKVNVSLTDHKNERGLYNVHLYYVETNGKLVGVGGTTYTVPAKVEETHTTTSYSLPDAG
                     TYTFKERSSIKAEPRVASPELAYYDAGMSVNYDKIVSGDGYQWLSYLSYNGNRRYVAVS
                     KLAQQESKPSGTINIENLSNLGFDVHITNVSGGDKAIQGVSVPVWTAQNGQDDLVWHQA
                     DRQSDGSYKVRINVSDHKAEAGEYIVHLYYVQDGKMIGIGGTSTTVPVQNATRHNLPAS
                     GSYTFTARTGIKTQPLVANPDVSYYDSGMSVNYDKVVNNDGYTWLSYLSYSGHRFYVAI
                     APTSVTKPVEQPVQPSTPSSGTYTFKERSSIKAEPSVASPELAYYDAGMSVNYDRLVTA
                     DGHTWLSYVSHGGNRRYIAIDGKATAVAQPASPSLAATGTYTFTKPSSIKAQPSVASPE
                     LAYYDKGMSVRYDKVLTADGHTWLSYVTYSGARRYVDIS"
     gene            6052..6804
                     /locus_tag="I4U27_RS00420"
     CDS             6052..6804
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002886759.1"
                     /locus_tag="I4U27_RS00420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_195914435.1"
                     /transl_table=11
                     /translation="MLDIFVLEEDYFQQARLEDAIHKSKQIYILRIGKVDLYDKPNQLL
                     ERITERGSHLLFFLDIGSDSDVEGGILVAQQIRERDPYASIVFITAHPELLPSTFQYRL
                     AALDFIDKNLPDNEYEDRIISDIGLALSKNGLSQIECAFTVDTKNATIQVPFHKILYFE
                     TSPTVHKVILHTTEEQIEFYGQLSKIVKQDCRLYKCHKSFVVNPENIVRLDKELGIIYF
                     ENGESCLVSKAKQKEIVAKMLVPKTIAV"
     misc_feature    6879..6899
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 27.05"
                     /tool="antismash"
     gene            6939..7604
                     /locus_tag="I4U27_RS00425"
     CDS             6939..7604
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002886760.1"
                     /locus_tag="I4U27_RS00425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6287 domain-containing protein"
                     /protein_id="WP_195914436.1"
                     /transl_table=11
                     /translation="MKNTSKLIGIVLALIVVILAVFLVTKFNSHESARVSTSSSPAKAV
                     KKSSSSSSKVVKKDKKSTQSSSSAVTNEENDNQDSAVAPKASSQEQAQVGATDGGQVAE
                     SAAGTDKAKSEKNTNNSQSSLDFGALDNGDISSLVGTWTNANGESVTINSDGTIIKNST
                     GYTAQLKPQRVSDNIFYAGVFSDTSSAALRAISGGSNGSDYLVIGQDQTAEGVPYYRN"
     gene            7683..>8623
                     /locus_tag="I4U27_RS00430"
                     /pseudo=""
     CDS             7683..>8623
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611514.1"
                     /locus_tag="I4U27_RS00430"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKLTYEDKVQIYELRKQGESFKRLSNQFGVNVSGLKYMVKLIDRY
                     GINIVRKGKKRYYSPKLKREMIDKVLLEGCSQQSVCLDYGLSNQGLLNNWIAQYKKNGY
                     TIVEKTRGRPPKMGRKPKKKPEEMAALERLQAENEYLRAENAVLKKLRELRLRDEKEQE
                     EKRKLFENW"
     gene            complement(<8764..9179)
                     /locus_tag="I4U27_RS00435"
                     /pseudo=""
     CDS             complement(<8764..9179)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767230.1"
                     /locus_tag="I4U27_RS00435"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAQFTNRFYLTS"
     misc_feature    complement(9314..9329)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.01"
                     /tool="antismash"
     gene            9399..9521
                     /locus_tag="I4U27_RS10200"
     CDS             9399..9521
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017370910.1"
                     /locus_tag="I4U27_RS10200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative RiPP precursor"
                     /protein_id="WP_110981054.1"
                     /transl_table=11
                     /translation="MNYTKPVIEKISTFKSGTSGLVAGRFRDIFGGRALFLIRI"
     misc_feature    complement(9594..9609)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: strong, score: 27.47"
                     /tool="antismash"
     gene            9756..9884
                     /locus_tag="I4U27_RS00440"
     CDS             9756..9884
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003094871.1"
                     /locus_tag="I4U27_RS00440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative RiPP precursor"
                     /protein_id="WP_110981053.1"
                     /transl_table=11
                     /translation="MKYCKPTFEPIATFKKDTKGLWTGNFRDVFGGRAIVRVRIEF"
     misc_feature    complement(9767..9780)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.45"
                     /tool="antismash"
     gene            10001..11728
                     /locus_tag="I4U27_RS00445"
     CDS             10001..11728
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017370911.1"
                     /locus_tag="I4U27_RS00445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_110981052.1"
                     /sec_met_domain="Asn_synthase (E-value: 6.8e-25, bitscore:
                     83.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNKYFFEKYSDKKIIFLTKNLYRTVSGDNKIIYCLEDYVEEVCS
                     IIEQNDISSFEETISVLQNYVINGLIIVEMAERTYIISPYLDSRLSWFENNKNIIFSDS
                     SVEIAKYLNLKLSPKRLASQFIFGLPYYPFQTISLWEELVNIKPLNYLEISEKGCLEKR
                     VPSYEVDTNDFNKLIIKIKEEFLNSINHDLNMGNEVSSDVSGGVDSATIAFTLNKLIPD
                     FSILHSESSTTANSDTKWATFIAKNLGRELNKFDSIEKTEKRFSVDEKYINDIIPSSPL
                     LWADSEGYLKSVIDYQKDRKHPTHFLGIGGDELFTPMPSNPWNIVRQENLGGLLYALKY
                     SLIMRRPFFSCLLDLIDNRGYSETVTQNLEIVFSESSEPIKRKLGWVDGLQVPDWLSEK
                     SKQESQSFLHSLLFSNSDPIISDRTTFQMIQSLIFQKSVLRQIQLTTNSIYWATPFLHK
                     KLVEICLQIPAKYKVSSKLTKPILQRALKGIVPIEVFNRGFKGDYSDALYSGYREAVRK
                     NFHRLEQFELVKMGIVDVEKLKLELSLPAGNPSKIDYFEKLCSVERWIRQIKLYMKDE"
     misc_feature    complement(10015..10028)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.91"
                     /tool="antismash"
     gene            11740..11991
                     /locus_tag="I4U27_RS00450"
     CDS             11740..11991
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thurincin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775110.1"
                     /locus_tag="I4U27_RS00450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_110981083.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 8.7e-23,
                     bitscore: 75.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 2.9e-08,
                     bitscore: 28.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 2.2e-08,
                     bitscore: 29.0, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.7e-14, bitscore: 47.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFNKGSKSRLKIIKQDNGAIVFDKNQGVYFQTNDVGVKILELLSK
                     NKSEEDIVSAISGAYSIEIDVAKQDVKDFIQSLKKGGI"
     aSDomain        11758..11988
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I4U27_RS00450_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.00E-24"
                     /identifier="RREFam002.1"
                     /label="I4U27_RS00450"
                     /locus_tag="I4U27_RS00450"
                     /protein_end="83"
                     /protein_start="6"
                     /score="75.1"
                     /tool="antismash"
                     /translation="KSRLKIIKQDNGAIVFDKNQGVYFQTNDVGVKILELLSKNKSEED
                     IVSAISGAYSIEIDVAKQDVKDFIQSLKKGGI"
     aSDomain        11764..11973
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I4U27_RS00450_Subtilosin_rSAM_RRE.1"
                     /evalue="1.60E-09"
                     /identifier="RREFam018.1"
                     /label="I4U27_RS00450"
                     /locus_tag="I4U27_RS00450"
                     /protein_end="78"
                     /protein_start="8"
                     /score="28.9"
                     /tool="antismash"
                     /translation="RLKIIKQDNGAIVFDKNQGVYFQTNDVGVKILELLSKNKSEEDIV
                     SAISGAYSIEIDVAKQDVKDFIQSL"
     aSDomain        11788..11985
                     /aSDomain="Thurincin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a thurincin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I4U27_RS00450_Thurincin_rSAM_RRE.1"
                     /evalue="1.30E-09"
                     /identifier="RREFam019.1"
                     /label="I4U27_RS00450"
                     /locus_tag="I4U27_RS00450"
                     /protein_end="82"
                     /protein_start="16"
                     /score="29.0"
                     /tool="antismash"
                     /translation="NGAIVFDKNQGVYFQTNDVGVKILELLSKNKSEEDIVSAISGAYS
                     IEIDVAKQDVKDFIQSLKKGG"
     gene            11995..14217
                     /locus_tag="I4U27_RS00455"
     CDS             11995..14217
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922428.1"
                     /locus_tag="I4U27_RS00455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_195914437.1"
                     /sec_met_domain="PF13471 (E-value: 6.1e-20, bitscore: 66.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDMQLNQESYSYVQLKYRLLAQIALLISYPLTKSSPKRIESLINK
                     LSDSKLSATENEAVLARDAICTVSRKCRNQDGCVKRSLGVIMFLLFLNKRASWCTGFAM
                     DPFRSHAWVEVNGNPIKELEEVSSYERVVKTLDDKNEERKHMISEDIEKVDDTITSVKF
                     RDLLALIENKRKYFLIVLCLGILTSILTLLQPELLSKVISQKGVNLLNNPTIYTLIAIT
                     VGSTIISSLQYYFLQLMGESAVFQSRKSLIIQFLKLPIYKYNDLSAGDLISRFSSDTSK
                     LRAGIVQSTVALTSGLFLSLGAIFTLFLKDTYLAIITIISIALSFLFILFMSSLIQTAS
                     YKAHQGLGKMTAYLNRLIVGIRTIRSTNETNSELSKMLSEAQEVKNLGIGVARVQSIMT
                     PISNFSLQLCGIIILGVGGYRVSTGQMSIANLTSFMLLMYIAISPVGQIFSSVTTISEA
                     LGALGRITEIIDLPKEEDNDIILNLESTSDRSKAIEFANVTFSYDSYQFQDIQSDDNYI
                     LKDITFEINSGDYVSIVGPSGAGKSTLLYLIERFYDITSGGIKIFGQDFRTMNRETLRS
                     NIAYVEQNSPLVAGTILENLKMGNSNVTYDECCDALEKVGLEHLIQRGASGIESPIGEG
                     SFNLSGGERQRLAMARAILSDAKILLLDELTSNLDSLSEKKMKEAIKGMRGERTIIMVA
                     HRLSTILDSDKIFVLEHGRLVGSGTHVELLESVPLYKELAKEQFLA"
     gene            14230..14946
                     /locus_tag="I4U27_RS00460"
     CDS             14230..14946
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922427.1"
                     /locus_tag="I4U27_RS00460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_195914438.1"
                     /transl_table=11
                     /translation="MTNKIEIRDVTKTFKEGDILKNVSFTAEEGEVTAFLGPNGAGKSS
                     TLRILLGLDRPSSGTALIGGKKYCDIERPLLTVGASFDGVGAPSDRTVFQHLKIAAASN
                     GIDYSRISEVLSITDIEHKRNSKIGNLSLGEGQRLGIATALLGNPQYLILDEPTNGLDP
                     SGIRWFRNFIREQASTGKTVLLSSHILSEVEAVTDKVVFIDKGSIIALGTLHNILNGFD
                     NLEDVFFHLTGGDYDE"
     gene            14936..15727
                     /locus_tag="I4U27_RS00465"
     CDS             14936..15727
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017370914.1"
                     /locus_tag="I4U27_RS00465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_195914439.1"
                     /transl_table=11
                     /translation="MMSSIKSHNTLSELYKIFYSRSTKIVLPIVFIFQPLLSYISSKQI
                     LAVGLNATPETNSSLVEPIPPIEYIGFEAILLGLFAMIILGAILGSMEYKNSSLRTSLL
                     LCSNKAVFFVIKFFVTSVFIFIVSFVSIYLSIASAQFGLEREGLSPLILSNNVWYFILL
                     GSLSWSLLTVLSYSIAFYFKSSLGSLLFLLPQVYNLGSFLADRIQLAKYLPVSLGQDLI
                     ATSPLKITTPGRSVLFLSTWVLVISSFAYYKFLKEDVGNVR"
     gene            15724..16431
                     /locus_tag="I4U27_RS00470"
     CDS             15724..16431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012028134.1"
                     /locus_tag="I4U27_RS00470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_195914440.1"
                     /transl_table=11
                     /translation="MNSFRSEYLKFIYNKWLLLTVLSTIILVPLFVIFLHETPSYITED
                     YVLTQILESFYLGQAGIIIITILFIGQEFTGSTLRSSLLANPTRWKFFFIKLIVILSIS
                     ILVWSLVAFCTICVVYTFYGLLNPLLIYTFALRIILVSIGLILICFSLVLITRSIVVPM
                     GMSLSFLLGLGQMLLQFSDAFLYFPIISTMNSFFMIENQSYIPYTIGIAIQFLWGILLL
                     SFSILLFRKRIVR"
     gene            16462..17145
                     /locus_tag="I4U27_RS00475"
     CDS             16462..17145
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922424.1"
                     /locus_tag="I4U27_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_110981048.1"
                     /transl_table=11
                     /translation="MKEKKVYRILAIDDDESILRLIKNSLERSEFEVTTRREVGNIDIC
                     SFIGFDLILLDIMMSIDGLEICKSIREQIDVPIIFVTAKQLDSDLASGVKAGADDYIKK
                     PFSITELVARVRMHIQREERNRKNNKEICTKNLIINVSNQEILIEEETISLTKREFTIL
                     YTLASNPKRVYSVEELYERIYPSESDAQFRSIAEYIYQIRSKLKPFSINPIKTQWGGGY
                     SWNEN"
     gene            17130..18227
                     /locus_tag="I4U27_RS00480"
     CDS             17130..18227
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775619.1"
                     /locus_tag="I4U27_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_110981047.1"
                     /transl_table=11
                     /translation="MERKLDFKALVKKTQWTIVKQFCLNVIVAYIFPISTISIDIHSEN
                     QSIASGLLGLLFNVFSWVYICISLIIIVSINIKALLTRVKQEMEIVYHGSMWLTSVNNS
                     SNLTILEFIETNKHIELMQQRIKNMIQVEKDQKEDILFKVSAMAHDLKTPLTVIKGNSE
                     LLQLAPLSGVDVQCLKDIERASNQLDSYFNQLINYSKTFYSYQISFHQYRISNLSKILE
                     QECEYLIGDNIDYKYNSKIDRDCNIELDLDLIIRSVANIVNNAMAYADDSKKRIRVIFE
                     LEDGSIALSIWNNGSKFSDDVLKNFGKLFYREDTSRNSQFEHFGIGLAFVKQVMSIHSG
                     DIQLQNKEKGAMVKLIIPIKNSDNT"
     gene            complement(18442..19328)
                     /locus_tag="I4U27_RS00485"
                     /pseudo=""
     CDS             complement(18442..19328)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010898675.1"
                     /locus_tag="I4U27_RS00485"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS30 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSYSHLTITDRITIETYLELGLKPCQIASKLGVHKFTISRELKRC
                     QNGYSAALAQEQYDHKAKQKGRKSRLTPELKKEIENCLKSSWSPEQIYGRYQLEQKPMV
                     AFKIIYN"
     gene            19539..20273
                     /locus_tag="I4U27_RS00490"
     CDS             19539..20273
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002886762.1"
                     /locus_tag="I4U27_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_195914441.1"
                     /transl_table=11
                     /translation="MLNIYVLEDHFIQQNRIEEVIHTVLKKNNIKVGDFEVFDKPNQLL
                     ESITERGSHQLFFLDIQIKDDTKKGLEVAKQIRKNDPYANIVFFTTHSEYLPLTFQYQL
                     AALDFIDKSLEGEDFQKRVESIILLTCKKIQSQNPEDAFRIENVKTVIQVPFHDILYFE
                     TSDIVHKVILYTKEEQIEFYGSLSQIEKSDPRLFKCHKSFLINPENVIKLDKSTGTVYF
                     ENGGICYVSKLKLKKLLERISL"
     gene            20270..21589
                     /locus_tag="I4U27_RS00495"
     CDS             20270..21589
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013990167.1"
                     /locus_tag="I4U27_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_195914442.1"
                     /transl_table=11
                     /translation="MTAINFVLDNLDFLVEIILFILIYQYITSEKIKLRWYIIIPLIMR
                     FLFVLSPALSYVIGHAFLVVYSLYRNRYGNRLLDIFYGLFPIIIESLVHNLIIYGIALV
                     INRHYLIVLNHFHLNLVIELLVFPVFWLIIKTLKVDFKALNYGFRKSFSKYFLLLIDIS
                     MLSYALLLQYITFFVQQSPGGRDWHVYLVVTYALLFLATLVYINATFSERLKEEVILQK
                     DRQMSDLAHYSQQIEQLYTDLRRFRHDYLNVLSSIKYGIDSKDMAIISDIYDNILEKTK
                     TRIEGKQYEIANLINIKDEAVKGVLASKILEAQGQSITIHLEVSDIFEISRMGLLDFIT
                     VLSIFLDNAIEASLDSSTKEVNIALISGETKVVIVENTIAQESINTVGIFKLGRSSKGE
                     GRGIGLSTVREILGKYPNCSLSTQSKDYRFKQTLKIEDVV"
     gene            21687..22337
                     /locus_tag="I4U27_RS00500"
     CDS             21687..22337
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003097751.1"
                     /locus_tag="I4U27_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6287 domain-containing protein"
                     /protein_id="WP_195914443.1"
                     /transl_table=11
                     /translation="MKNTSKLIGILSALIVVILAVFLVTKFNSHESARVSTSSSPAKTV
                     KKSSSSSSKAVKKDKKNSNPHVKSEDTEDTTVEVSEPSVAKDSATKDTNETVLSSGSVS
                     ETTKEKTGEETQTSSLNGNQLSSGDYSSIAGTWTNSRGEFVTISPDGTVQNGSGYTYHL
                     YSGHLNNGNFSGTIASDIDSAAFWAIPGTGNGDSDHLVIGQSDDAENYPFYRN"
ORIGIN
        1 tttgtcaaac agaagtttcg attgggtggc gaacgctttg atatcaagga tgatcaaggt
       61 agagttgcct atcaggttga aggatccttt ttcaagattc caaagacctt tacaattttt
      121 ggtgaggatg gtcgtgagat tagtcatatc accaaggagc cgcttagtct cttgcctaag
      181 tttacagtag acttgcagga tggttcgagt ttttacattc gaaaaaaatt aacccttctt
      241 cgtgataagt atgatgtcga taatcttggc ttgcgaatag agggtaatat ttgggacttg
      301 gattttcaac tacttaatag tcaaaatcag gtagttgcta ggattcaaaa ggagctcttc
      361 catctgacat cgacctatac tgttactgtt tatgaaaata cttacgccga tttggccatt
      421 tccctgtgtg ttgctattga ctatgtggaa atgctcgaga atagctcaaa ataagaaaca
      481 tttatttaag gagaaacaat gaaacaactt acttcagcac aaattcgtca aatgtggctt
      541 gatttctgga aatcaaaagg tcacgctgtt gaaccatcag ctaacttggt tccagttaac
      601 gatccaaccc ttctttggat taactcaggg gttgccactt tgaaaaaata ctttgatggc
      661 tctgtgattc ctgaaaatcc acgtatcacc aactcacaaa aggctatccg taccaatgat
      721 atcgaaaacg ttggtaagac agctcgtcac cacacaatgt ttgaaatgct tggtaacttc
      781 tcagttgggg actacttccg tgatgaagct atcgaatggg gttatgagct tttgacaagc
      841 ccagagtggt ttgattttcc aaaagacaaa ctttacatga cttactatcc agatgataaa
      901 gattcataca accgttggat tgcttgcggt gttgaaccaa gtcatttgat tccaattgaa
      961 gataacttct gggaaatcgg tgctggacct tcaggaccag atactgaaat cttctttgac
     1021 cgtggcgaag actttgaccc tgacaatatt ggtatccgtt tgcttgaaga agatattgaa
     1081 aacgaccgtt acattgaaat ttggaacatc gttttgtcac aattcaatgc agatccagct
     1141 gttccacgtt cagaatacaa ggaacttcct aataaaaaca ttgatacggg cgcaggtctt
     1201 gaacgtcttg tagccgtgat gcaaggggct aaaacaaact ttgaaacaga cctcttcatg
     1261 cctatcattc gtgaaatcga aaaaatgtct ggtaaaactt atgatccaga tggtgacaca
     1321 atgagcttca aggtcatcgc tgaccacatc cgttcattgg catttgccat tggtgatggt
     1381 gcccttccag gtaatgaagg tcgtggttat gtccttcgtc gtcttctccg tcgtgccgta
     1441 atgcacggcc gtcgtctcgg catttctgat gctttcttgt acaaacttgt tccaactgtt
     1501 ggtcaaatca tggaaagcta ttacccagaa gttcttgaga agaaagactt tatcgaaaaa
     1561 atcgttaaac gtgaagaaga aacctttgca cgtaccatcg atgcaggttc aagcatgctt
     1621 gacgagcttc ttgctaacct taagaaatct ggtaaagata cgcttgaagg taaagacatc
     1681 tttaaacttt acgatactta tggattccca gtggaattga cagaagagtt ggctgaagat
     1741 gaaggattca agattgacca tgaaggtttc aaagctgcca tgaaagaaca acaagaacgt
     1801 gcgcgtgcta gcgtggttaa aggtggttct atgggtatgc aaaatgaaac cctcgccaac
     1861 atcactgaac catctgagtt cttgtatgaa gcggaaacag cagaaagccg tttgagcgtc
     1921 atcgttgctg atgatgctcg tcatgatagt gttaactctg gtcaagcact ccttgtcttt
     1981 gaacaaacac cattctacgc tgaaatgggt ggacaagtag cagaccacgg tacgatctca
     2041 gatgcagctg gtacagtcgt tgcgcgtgtt gttgacgttc aacgtgcacc aaatggacaa
     2101 gcgcttcaca ctgttgaggt tgaaggtgaa cttgttgtag gtgctaacta caaacttgaa
     2161 attgaccaca cacgtcgtca ccgtgttatg aagaaccaca cagcgactca cctcttgcat
     2221 gctgcccttc ataatatcgt tggtgatcat gctgttcaag cgggttctct taatgaacaa
     2281 gaattcttgc gtttcgactt cactcacttt gaggctgtaa ctccagaaga attgcgtgct
     2341 atcgaagaac aagtcaacga agaaatctgg aaagccactc cagtaacaac tattgaaaca
     2401 gacattgaca ctgctaaatc aatgggagct atggccctct ttggcgaaaa atatggtaag
     2461 aatgttcgcg tcgtttcaat cggtgattac tctgttgagc tttgtggtgg tacgcacgtt
     2521 gccaacactg ctgaaatcgg tatgttcaag attgtcaaag aagaaggtat cggttcagga
     2581 acacgtcgta tcttggcagt gacatcacgt gaagcttacc ttgcttaccg tgaagaagaa
     2641 gatgccctta aagcaatcgc agcaacactt aaggcaccac aattgaaaga agtacctaac
     2701 aaggttgcta gccttcaaga gcagttgcat gcccttcaaa aagaaaatgc tgcgcttaaa
     2761 gaaaaagcag ctgcagctgc agctggtgac gtcttcaaag acgttaaaga agctaaaggt
     2821 gttcgttaca ttgctagcca agtagaagtt tctgatgcag gtgcccttcg taccttcgcg
     2881 gaccaatgga aacaagcaga ctactctgat gtccttgtcc ttgcagctca cattggcgaa
     2941 aaagttaatg ttcttgtagc aagtaagtct aaagacgttc acgcaggtaa tgttatcaag
     3001 gttctcgcac caatcgtatc aggtcgtggt ggtggtaaac cagatatggc catggccggt
     3061 ggtagtgatg ccaatggtat ccaagatctt ctttcagcag tagcagaaca gctctaagat
     3121 gtgatacaat aaaagtaact tgaaaaggta ggatgaaaat cctatctttt tttctttaaa
     3181 aactttagta ataatattga aataattgta aaaaatattt caaaggagta taatagaaat
     3241 gtgaaaacgg ttccaatgtt tatcaaacag cctagaaagt gagagtgatc aaaatgagaa
     3301 aggcatatgt tgttaaggaa cgtcaacgtt actcaattcg taaatattct tttggagctg
     3361 catcagtctt gattggtgcg agcttgatgc ttggtggaca tgctttggct caggaacaag
     3421 ccaacagcac aagtaccagc aaggattatg aagtttttgt aaataattct gaaccacttc
     3481 aaatcgacca ggcaacttca gaagctgtta ccgatgtcct caatcaacca gcttcaagat
     3541 ctgaagcgcc aagacctaag cttgctagca gtgaggttgc ctcttctgaa gctaatagtg
     3601 tagtggctag cgaggctgct tctttggaag taccggcaga ggttgctcat tctgcatctg
     3661 ctgttgctac tgtttctaga tcagaagtgg ctagcccacg ttctgaagtg tcatcagtag
     3721 ctagctctga agcagtaagt gatactaacc gttcagcaac ttcagaagta gcagaagcta
     3781 gagttactga ccgtgaagct gtggatactc ctcaacctgg tgtagatggt cctgtgactg
     3841 ctgatggttc tcttgatatt ccatcaaacg gcacctatta tttccgtcgc acaacagaaa
     3901 ttcgtactgc gccaatcatg gatatcaaac ctaccttcgt ctttagtgca ggcgaccatg
     3961 ttatctacga caaggtcttg aagagagaca atcaccaatg gatttcttac attggttacg
     4021 actatgaacg ctactacgct gatatcgcag ctttgaaggc tgaaaatact agtagcaaca
     4081 ctgaagcgac tagagatgaa accatccctg aacgtggtac ttattacttc actaaacctg
     4141 cagatgtgaa gaaccaacct agcttgactg ctaagactga gttcaatttt gatccaggta
     4201 tgtcagtcaa ctacgataga tctttgcttg ctgacaacca ccgttggatt tcatatgtgt
     4261 catacaatgg tactcgtcgt tacgtcgatc taggtgctgc agcagaggct gtagctaaac
     4321 caagaggcga tatcgctatt gaaagccatg ataatggtga ctttagtgtg gttatcagta
     4381 atgttttaga tcaaaacggt gtccttgggg tatctgtccc aatctggtct gaaaagaatg
     4441 gtcaagatga cattatctgg tacaatgcga ctcgtcttaa caatggtaac tacaaggtta
     4501 acgtcagtct aactgaccac aagaatgaac gtggcctcta caatgtccat ctttactatg
     4561 ttgaaactaa tggtaaatta gttggtgtgg gtggcacaac ttacacagtt cctgccaaag
     4621 ttgaagaaac tcatacaact actagctata gccttcctga tgcaggaact tacaccttca
     4681 aagaacgttc tagcatcaag gcagaacctc gtgtggcaag tccagagttg gcctactacg
     4741 atgctggcat gtcagtcaac tacgacaaga ttgtcagtgg tgatggttac caatggcttt
     4801 cttacctcag ctacaatggc aaccgccgtt atgtagccgt gtctaaactt gctcaacaag
     4861 aaagcaaacc aagcggtact atcaatattg aaaatctctc taaccttggt tttgacgttc
     4921 atatcactaa tgtttctggt ggtgataaag ctatccaagg cgtgagtgtt ccagtatgga
     4981 cagctcaaaa cggtcaagac gatcttgtat ggcaccaagc tgacagacaa agtgatggta
     5041 gctacaaggt tcgcatcaat gttagcgatc ataaggctga agcaggggaa tacatagtcc
     5101 atctctacta tgttcaagat ggtaagatga taggtatcgg tggcactagc acaactgttc
     5161 cagttcaaaa tgcaacccgc cacaaccttc cagcttcagg ttcatacacc tttaccgctc
     5221 gtactggcat caagacccaa cctttggtag ccaacccaga tgttagctac tacgattcag
     5281 gcatgtcagt caactatgat aaggttgtca ataatgatgg ctatacatgg ctttcttacc
     5341 tcagctattc aggacatcgt ttctatgtgg ctatcgcacc aacaagtgtg actaaacctg
     5401 tagaacaacc tgttcaacca agtacacctt catctggtac ctatactttc aaagaacgct
     5461 ctagcattaa agcagaacca agtgtagcga gtccagagtt ggcttactat gatgctggta
     5521 tgtccgttaa ctatgacaga ttggtgactg cagatggtca cacatggctc tcttatgtta
     5581 gccatggagg aaaccgtcgt tacattgcca ttgatggtaa ggcaacagca gttgctcaac
     5641 cagcaagtcc aagcctagct gcgactggta cttatacctt taccaaacct agctctatca
     5701 aggctcaacc aagtgttgca agtccagagt tagcctacta tgataaaggc atgtccgttc
     5761 gatatgacaa ggtccttaca gctgatggac acacatggtt gtcttatgta acctatagcg
     5821 gtgcaagacg ctatgtagat atttcttaag agttttaaca tcactctctt ttgagggtgg
     5881 tgttttttta gtttcaagag ttgaatcaat atattgttca atatgtttta gaagcatttg
     5941 ctgtaaatta gagaaagttg taaaatcaag gtgaaaatat aggattagtt ctacaagtag
     6001 ctaattcagc aagttattga aagaaaatgt tataaaacgg aggtactgag catgttggat
     6061 atttttgttt tagaagaaga ttattttcaa caagctcgtc ttgaggatgc catccacaag
     6121 tctaaacaaa tatatatttt aagaattggg aaggttgatt tatacgataa acccaatcaa
     6181 ttattagagc gtattacgga aaggggctcg catttactgt tttttctaga tattggatct
     6241 gacagtgatg tcgaaggggg aatattggtt gctcaacaga ttcgtgagcg agatccgtat
     6301 gcaagtattg ttttcatcac agcacatccc gaactcctac cttcaacctt tcagtatcgc
     6361 ttagctgcac ttgattttat tgataagaat ttgcctgata atgaatatga agataggatt
     6421 atttctgata ttggattagc actttctaaa aatggtctga gccaaataga gtgtgctttt
     6481 acggtagata caaagaatgc aactatacaa gttccttttc ataagattct ctattttgaa
     6541 acatctccaa cggttcataa ggtgattctt catacaacgg aagagcagat tgagttctat
     6601 ggtcaattgt caaaaattgt gaaacaagat tgcagactat ataaatgcca taaatcattt
     6661 gttgtaaatc ccgaaaacat tgtgagattg gacaaagagt taggtattat ttattttgaa
     6721 aacggagagt catgcttggt ttcaaaagct aaacaaaaag agattgttgc taagatgctt
     6781 gttccaaaaa ccatagcagt ttgatgtata tagtattttt attttaaatg ttattttctg
     6841 attatgacga aaaaaccacc gtttatgact tcaatgaaaa atttagcttt ctctatatta
     6901 taataaccta gtaaattatc agaaaaggaa catcactcat gaaaaataca agtaaactca
     6961 ttggtatcgt attagctctt attgtagtta tcctcgctgt cttcttagtg actaagttta
     7021 atagtcatga gtcggcgcgt gttagcacaa gtagtagccc agccaaagcg gttaagaaat
     7081 catcctcaag ctcgagtaag gtcgttaaga aggataagaa atcaactcaa tcatcatctt
     7141 cagcagtcac aaatgaagaa aatgacaatc aggattcagc agtagcacct aaagcttctt
     7201 ctcaagaaca agctcaagta ggcgctacag atggtggaca agtggctgaa tctgcggctg
     7261 gaacagataa ggctaaatct gagaagaaca caaataatag tcaatcctcg cttgactttg
     7321 gtgcccttga caatggtgat attagctctc ttgtgggaac ttggactaac gcgaatggtg
     7381 aatcagtgac tatcaattct gatggtacaa ttattaaaaa ctcaacaggt tatactgctc
     7441 aattgaagcc tcaaagagtt tcagataata ttttctatgc aggagttttc tcagatacaa
     7501 gctcagctgc attgagagcg atttctggag gcagtaacgg ctctgattac cttgttattg
     7561 gtcaggacca aactgctgaa ggtgtccctt attatcgtaa ctagtacgaa aaagattgct
     7621 atttatgaac tgcaccccaa aagttagaca gataaaatct aactttgtgg ggtgttttta
     7681 ttatgaaatt gacttatgag gataaagttc aaatatatga actgagaaag caaggagaaa
     7741 gctttaaacg actttcaaat caatttgggg tgaatgtttc tggtctaaag tacatggtta
     7801 aattaattga tcgttatgga ataaacatcg ttagaaaggg aaagaaacgt tactattctc
     7861 ctaaattaaa acgagaaatg attgataaag tcctacttga aggttgttct caacaaagtg
     7921 tttgcctgga ctatggcctc tcaaatcaag gattgcttaa caattggata gcacaataca
     7981 agaaaaatgg gtatactatt gttgaaaaaa caagagggag accgcctaaa atgggacgta
     8041 agccaaagaa gaaacctgaa gagatggcag cgctagagcg acttcaagca gaaaatgaat
     8101 acctgagagc ggagaatgct gttctaaaaa agttgagaga actccgattg agggacgaga
     8161 aagagcaaga agaaaaacgg aaattgttcg agaattggta acagagtttg ctttagatat
     8221 tcttctaaag attattaagc ttgctcgttc gacctattat taccacttga agcagctaga
     8281 tcaaacggat aagaatcaaa ctatcaaaac tgaaattcaa gctattttta ctgaacacaa
     8341 gggaaattat ggttatcgtc ggatacattt agaattaaga aatcgtggtt ttttggtcaa
     8401 tcataagagg gttcagcgat tgatgaacgt actcaattta caagctagaa tccggcagaa
     8461 acgcaagttt tcttctcaca aaggagatat aggtaagaaa gccgacaacc ttattcaacg
     8521 ccagtttgaa gcttcaaaac caatggaaaa gtgctacaca gatgtgacag aatttgccat
     8581 tccagcaagg agtaagaaaa ctctttttgt tgctagtata ctgactccaa aaagttagaa
     8641 atttaaatag tttatttatg acgaagtttt tagtaatgat aaattggaag aataagtgca
     8701 acacttactt gaactcatcc tctagagctt cacaagtagt tctataagct aaacattctc
     8761 ctaagttgct tttgagatat tagaaattgt gacaggacta tattgataac catacattcg
     8821 atcgatgata tcaacaattt ctcgagttgt tacaccggtt tgataaccat ctcttccaag
     8881 gggacatctc gacgtccata agcgggaagc aaagatgggc taaagttccc attacaatct
     8941 cttggaatgg ttaactgaac agtccccata tttggtttca agtttccgtg aatacgttcc
     9001 attgcgacta ttaccagaat tgtagcctgc tttttcgtaa ggcacatacc ctaaaaaggc
     9061 tgataaatca gcttggagta gattattctt agctgtatca agagaagaac ggaaaaattc
     9121 atcaatatct tgctttgggg ttaggatgtt aagtaaaatc tgttggtaaa ctgagccata
     9181 ggaataaatt tctttctagt aatgtttcgc aactctacta taacggattt attccttttt
     9241 gtgtttacac aacttatttt acactaccct tatattccac taccatcagg aattgtttat
     9301 aaatttattt tttctgaaaa aaatctgaat aatctttgtt attattttaa tagtcaagca
     9361 gtctggacta ttaaatattg acttagaaag gaaagtatat gaattatacg aagccagtta
     9421 tagagaaaat ttctactttt aaaagtggta cttcaggatt agtcgcaggt agattcagag
     9481 atatatttgg tggcagggct ttatttttaa ttagaatata atctattacc cgaacatatt
     9541 cattaagtta atatagtatt tattatggaa aacaagtaat ccacagagtg gaggtgaaaa
     9601 aaatctgaaa tttgttcaat cttaatctat tttctgattt ttttccgaaa ttcatattat
     9661 agaatttaat taaatcaaga agtatctctt gaaaattatt tttcatttac accaatgggt
     9721 tctggcatta gtctaaatga tagaaggagt ttaaaatgaa atattgcaaa ccaacatttg
     9781 aaccaattgc aactttcaaa aaagacacta aaggtctatg gactggtaat tttcgtgatg
     9841 tctttggtgg acgtgcaatc gtaagagtta gaattgagtt ttaagcttag aactatgtat
     9901 tacaacggta aataattttg aataaagtgt ttcgatattc attccagaac tacgaatatc
     9961 gagatgcttt acttttttat ttttgaggtt gttaatatat atggtaaata agtatttttt
    10021 tgaaaaatat tctgataaaa aaataatatt ccttactaaa aatttatata gaaccgtttc
    10081 tggagataat aaaataatct attgtttaga agactatgtc gaagaagtat gctcaattat
    10141 agaacaaaat gatatcagta gttttgaaga aacaatatca gtacttcaga attacgttat
    10201 aaatggttta attattgttg agatggctga aagaacatat attatttctc cttatttaga
    10261 ttcgagacta tcttggtttg agaataataa gaatataatt tttagtgatt cctctgtaga
    10321 aattgcaaaa tatttgaatt taaaactctc tccgaagcgt ttagcgagtc aatttatttt
    10381 tggacttcca tattatccat ttcaaacaat tagcctatgg gaagagctag taaatataaa
    10441 gcctttaaac tatttagaaa tatctgaaaa agggtgttta gaaaaaagag ttccaagtta
    10501 tgaagtagac acaaatgatt ttaataaact aataataaaa ataaaagaag agtttttaaa
    10561 tagcattaat catgatttga atatgggaaa cgaagtgtcg agtgatgtat caggaggtgt
    10621 tgattctgca actattgctt ttacattgaa taaactgata cccgacttct ctattttgca
    10681 ctctgaatca agtaccactg ctaatagtga tactaaatgg gcgacattta ttgcaaaaaa
    10741 tcttggtagg gagttgaata agtttgattc aatagaaaaa acagagaaaa gattttcggt
    10801 agatgaaaaa tatatcaatg atattattcc aagttctcca ttactgtggg cggattcaga
    10861 aggatatttg aaatcagtca ttgattatca gaaagataga aaacatccga ctcactttct
    10921 aggtattggt ggtgatgaat tatttacacc aatgccttct aatccctgga atattgttcg
    10981 tcaggaaaat ttaggtggac tcctttatgc tctgaaatat agtctgataa tgagaagacc
    11041 attttttagt tgtctattgg atttgataga caatagagga tattcggaaa ctgtgaccca
    11101 aaatttagaa attgtcttca gcgaatcttc tgaacctatc aagagaaaac tgggatgggt
    11161 ggatggtcta caagtaccag attggctcag tgaaaaatcc aaacaagaat cgcaaagttt
    11221 tttacactcg ttattatttt ccaattctga tccaataata tctgatagaa caacattcca
    11281 aatgattcaa tccttaatat ttcaaaaatc agtattgcga caaattcaat taactactaa
    11341 ttccatttat tgggcaactc catttttaca taaaaaatta gtagaaattt gtcttcaaat
    11401 tccagcaaaa tataaagtta gttcaaaact aacaaaaccg atattgcaaa gagcattgaa
    11461 gggaatcgta ccaattgagg tttttaacag gggtttcaaa ggggattatt cagatgcctt
    11521 atatagtgga tatagagaag ctgttcgtaa aaacttccac aggttagaac agtttgaatt
    11581 ggttaaaatg ggtattgttg atgttgagaa gttaaaatta gagctgtcat taccagcggg
    11641 aaatccgagt aaaatcgatt attttgaaaa gttatgttcg gtagaacgtt ggattaggca
    11701 gatcaaatta tatatgaagg atgagtgagg tttgtaatta tgtttaataa agggtcgaaa
    11761 agtagactga aaataataaa gcaagataat ggtgcaattg tatttgacaa aaatcaaggt
    11821 gtatactttc aaacaaatga tgtaggtgtt aaaattttag agttactgtc taaaaataaa
    11881 agcgaagaag atattgttag cgctatatct ggtgcgtatt ccattgaaat cgatgttgca
    11941 aaacaagatg ttaaagattt tatacaatct ctaaaaaaag gagggatata gattatggat
    12001 atgcaactca atcaagagtc atactcctat gttcagctaa agtacagatt actagcacaa
    12061 atagctttac tgatctctta tccgcttaca aagtcctcgc ctaaaagaat tgaatctttg
    12121 attaataagt taagtgactc gaaattatct gccacagaaa atgaagcagt attagctcgc
    12181 gatgcaatat gtactgtaag ccgtaagtgt aggaatcaag atggatgcgt aaaaagatca
    12241 ttgggagtaa taatgttttt acttttttta aataaacgtg caagttggtg tactggattt
    12301 gctatggacc cctttagatc tcatgcgtgg gtggaagtaa acggaaatcc aattaaagag
    12361 ctggaagaag tatcatcgta tgaaagagtt gtgaaaactc tagatgataa aaatgaagag
    12421 cgtaaacaca tgatatctga agatatagaa aaagtagatg atactattac tagcgtaaaa
    12481 ttccgtgatt tacttgcttt gatagaaaat aaaagaaaat attttttaat cgttttatgt
    12541 ttgggaatac ttacatccat tttaacgtta ttacaaccag aacttttgtc taaagtaatc
    12601 tctcaaaagg gagtaaattt attgaataat ccaaccatat atacgcttat agctattacc
    12661 gtgggttcaa caattatttc cagtttgcaa tattactttt tacaattaat gggagaaagt
    12721 gcagtatttc aatcaagaaa aagtttaatt attcaatttc tgaaacttcc tatttataaa
    12781 tataatgatc tatctgcagg agacctaatt agtcgcttta gtagcgatac aagtaaacta
    12841 agagcaggta tcgttcaatc aacagttgct ctgacgagtg gattgttctt gagtttaggt
    12901 gcgatattta cattatttct aaaggatact tatcttgcaa taattacaat tatttctata
    12961 gctttatcat tcctatttat tttatttatg agtagtttga ttcaaacggc aagttataaa
    13021 gctcatcagg gtttggggaa aatgacagcg tacttaaata ggctaatcgt aggaattaga
    13081 acaattcgat cgacaaatga aacgaattca gaattatcta aaatgttatc tgaggcgcaa
    13141 gaagtaaaaa acttgggaat tggagttgca agagtgcaat caataatgac accgatatcc
    13201 aattttagct tgcaattgtg tgggataatt attttgggag ttggaggtta ccgtgtttct
    13261 actgggcaaa tgtctattgc aaatctaact tcttttatgc tattaatgta tatcgctatt
    13321 tcaccagtag gacaaatatt ttcgtcagtc acaactattt cagaagcttt gggagcttta
    13381 ggtagaatta ctgaaattat tgatcttcca aaagaagaag ataatgatat cattttaaat
    13441 ctagaatcta cgtcagacag aagcaaagca attgaatttg cgaatgtaac tttttcatat
    13501 gattcttacc aatttcaaga tattcaatcg gatgataatt atatattaaa ggatattact
    13561 ttcgaaataa atagtggaga ttacgttagt attgtaggtc cgtctggtgc ggggaaaagc
    13621 acacttcttt acctcattga aagattctat gatattacta gtggtggtat aaagatattt
    13681 ggacaagatt ttcgaacaat gaatcgtgag actttacgtt cgaatattgc atatgttgaa
    13741 caaaattcac cattagtagc tggtacaatc ttagaaaatc taaaaatggg taatagtaat
    13801 gtaacatatg atgaatgttg tgacgcttta gaaaaagttg gtttggagca tttaattcaa
    13861 agaggtgcat ccgggattga aagcccaatt ggtgaaggaa gtttcaattt atcaggagga
    13921 gaaagacaga gattggcaat ggcaagagca atactttccg atgcaaagat actcttgctg
    13981 gatgagttaa cttcgaattt agatagtctt agtgagaaga aaatgaagga agcaatcaaa
    14041 ggtatgagag gtgagaggac tattataatg gttgctcata gattatctac aattttagat
    14101 tcagataaaa tctttgtttt ggaacacgga agacttgtag gaagtgggac tcatgtggag
    14161 ctattggaat ctgttccatt atataaagag ttggccaaag aacaattttt agcataggag
    14221 tatcgtatta tgacaaataa gattgaaata agagatgtta caaaaacttt taaagaagga
    14281 gatatattaa agaacgtatc ctttacagct gaagaggggg aagtcactgc ctttttggga
    14341 ccgaatggtg ccggaaaaag ttcgacacta cgaatacttt tgggtctgga taggccatct
    14401 tcaggaactg ctttaatagg aggtaagaaa tattgtgata ttgaacgtcc tcttttaact
    14461 gtaggagctt cttttgatgg tgtgggggct cctagtgatc gaacagtttt tcaacatttg
    14521 aaaattgctg ctgctagtaa tggaatagat tattccagaa tatcagaggt gttatccatt
    14581 actgatattg aacataaaag aaattcaaaa ataggcaacc tttccttggg agagggtcag
    14641 agattaggta ttgcaacagc gctgttggga aacccccagt acctgatttt agatgaacct
    14701 acaaatggtc tagatcctag tggaattaga tggtttagaa attttattcg ggaacaagca
    14761 agcactggta agacagtatt gttatcttca catatacttt cagaagtaga agcggtaact
    14821 gataaggttg tttttattga caaaggaagt atcatagctt tgggtacact tcataatata
    14881 ttgaacggat ttgataatct agaagatgtt ttctttcatt taacaggagg tgactatgat
    14941 gagtagtata aaaagccata atactttatc agagctatat aaaatttttt atagtagatc
    15001 aaccaaaata gttttaccaa ttgtttttat ttttcagccg ttattgtctt atatcagttc
    15061 taaacaaatt ttagcagttg gattgaatgc aacccctgaa acaaatagta gcttagtaga
    15121 accaatacct ccaattgagt atattggttt tgaagctata ctattgggct tgtttgctat
    15181 gattatttta ggagcaattc ttggaagtat ggaatataaa aatagttctt tacgtaccag
    15241 cttgttatta tgttcaaata aggcagtatt ctttgtaata aaattttttg tcacaagtgt
    15301 atttattttt attgtgtcat ttgtttcaat ctatttatct attgcaagtg cacagtttgg
    15361 tttagaaaga gaaggattga gccctctgat actgagtaat aatgtttggt actttatatt
    15421 gttaggatca ttgtcgtggt cgctactaac ggtgttatcc tattcaattg ctttttattt
    15481 taaatcctca cttggatcat tattattctt attaccacaa gtctataatt taggtagttt
    15541 tcttgctgac agaattcagc ttgccaagta tttaccagta tctttagggc aagatttaat
    15601 tgcaacatct cctttaaaaa tcacaacacc aggacgcagt gttttatttt tgagtacttg
    15661 ggtgctagta attagtagct ttgcatatta caaatttttg aaagaagatg taggtaatgt
    15721 tagatgaatt cttttagaag tgagtattta aagtttattt ataataaatg gttattattg
    15781 actgtactat caactataat tttagtacct ttatttgtta tttttttaca tgaaactcca
    15841 agttatataa ccgaggatta tgttttaacg caaatcttag aaagcttcta tctcggacaa
    15901 gctgggatta ttattattac aatactattt ataggtcaag aatttaccgg ttcaacttta
    15961 agaagcagtt tattagctaa cccaacacgg tggaaattct tttttataaa attaatagta
    16021 atattatcaa tatctatatt agtttggagt ctggttgctt tctgtactat ttgcgtagta
    16081 tatacttttt atggtctatt aaatccctta cttatttata cctttgcatt aagaataata
    16141 ttggtatcaa ttggtttaat attaatatgt tttagtttag ttcttataac aaggagtata
    16201 gttgttccaa tgggaatgtc cttgtctttc ttgttggggt taggtcaaat gcttctgcaa
    16261 ttcagcgatg cttttctcta cttcccgatt atctccacta tgaattcatt ttttatgatt
    16321 gagaatcaat cttatatacc ttatacaata ggtattgcaa ttcaattttt atgggggatt
    16381 ttgctgttat ctttctctat tttgctgttt aggaagagga ttgtacgata aaaaatttgt
    16441 attttgtgat aatatttagt tatgaaagaa aaaaaagtat atcgaatatt agcaattgat
    16501 gatgatgaaa gcattcttcg tttgataaag aattctctag aacgctcaga gtttgaagtt
    16561 acgacgagga gagaagtagg taacatagat atttgttcat ttattggctt tgatttaatt
    16621 ttattagaca ttatgatgtc gattgatggt ttagaaattt gtaaatccat tcgagaacaa
    16681 atcgatgtac cgataatttt tgtaacagcc aagcaattgg atagcgattt ggctagcggg
    16741 gtaaaggctg gtgcggatga ttatataaaa aaaccattta gtattacaga attagttgct
    16801 cgtgttagga tgcatatcca aagggaggaa agaaatcgta aaaataataa agaaatatgt
    16861 acaaagaatt tgataattaa tgtcagtaat caagaaatct taattgaaga agagactata
    16921 tcattgacaa agcgagaatt tacaatttta tatactttag caagcaaccc gaagagagta
    16981 tattccgttg aggagctcta tgagagaata tatccgtcgg aatcagatgc acaatttcgt
    17041 tctattgcag agtatattta tcaaattcgt tcaaaattaa aacccttttc aattaatccg
    17101 atcaagacac agtggggagg cggatatagt tggaacgaaa attagatttt aaggctttag
    17161 taaaaaagac gcagtggaca attgttaaac aattttgttt gaatgtaatt gtagcctata
    17221 tttttcctat atcaactatt tctatcgata tccattcaga aaatcagtca atcgctagtg
    17281 gcttgttagg gctattattt aatgtttttt catgggttta tatttgtata tctttgatta
    17341 ttatagtttc tattaatatt aaagctttgt taacaagagt aaagcaagaa atggagattg
    17401 tttatcatgg tagcatgtgg ctaacctctg taaacaattc atcgaattta acaattcttg
    17461 aattcataga aacaaataaa cacattgaat taatgcaaca aagaattaaa aatatgattc
    17521 aggtagagaa agaccaaaag gaggatattc tctttaaagt ttcagcgatg gcacatgact
    17581 tgaagacacc tttgactgta attaaaggaa actcggaatt gttgcaattg gcacctttat
    17641 caggtgttga tgttcaatgt cttaaagaca ttgagagagc aagtaaccaa ttagatagct
    17701 attttaatca gttaatcaac tactctaaaa ctttttactc ttatcagatt tctttccatc
    17761 agtatcgtat tagtaattta tccaaaatac tggaacaaga gtgtgaatac cttattggag
    17821 ataacattga ctacaagtat aattcgaaga tagaccgaga ctgtaatatt gaattggatt
    17881 tagatttaat aatccgttcg gtggcaaata ttgttaataa tgcaatggct tatgcagacg
    17941 attctaaaaa gagaatcaga gttatctttg agttagaaga tggtagtatt gccttaagta
    18001 tttggaataa tggttctaaa ttttctgatg atgttttaaa aaattttgga aaattatttt
    18061 atcgagaaga cactagtaga aattcacagt ttgaacattt tggaataggt ttggcatttg
    18121 taaaacaagt aatgagcatt cattctggtg atatacaact gcaaaataag gaaaaagggg
    18181 ctatggttaa attaattatt cctataaaaa atagtgataa cacctaggtt tgaatatcgt
    18241 aatcttgaat tctatgaagt tcataaagta agcatattga taataattat ttcaaaatct
    18301 ttgcaattag cactcataac tgatttattc ggctcttttc caccatttgt caagtctatc
    18361 aaggctttaa gtaaagataa attgcatgaa tgagtgcaac atttactcga actcttctat
    18421 tagagcttca caagcagttt tctaagctaa atattttcgt gatcgatgaa taaaaccttg
    18481 ttcaaatcct cctcacagat agcggctaga tctgttttct ttgggaaata ttctcttagt
    18541 aagccatttg cgttttcatt gcttcctctc tgccaagatg tataggcgtc cgcaaagaaa
    18601 aaggaaattc ctaagttctc tactagagga tagcaggcaa actcttttcc cctgtctgaa
    18661 gtgaaggttt taagagcctc ttttggaaat agattacaga gttgttcgat ggctgaaaac
    18721 atggatttgg ctgttctatt tggtatcttg aaagctaagt aaaagcgagt tttccgctct
    18781 aggaatgtcg ctaaacagcc cttgcttttg cctctggaag ataccacagt atcgagctcc
    18841 cagtgaccaa aggtctcacg tttcctgacc tctttaggac gtttggcaat cgacgtgcca
    18901 atcctaaatg tcccacgtgt ttctttgggt tgtcgagtct tccctttacg acgaaggacg
    18961 cttaaatcca gatcaatcaa accagtatag agtcagttat agataatttt aaaagctacc
    19021 attggctttt gttcaagctg atagcggcca taaatctgtt caggcgacca ggaggatttt
    19081 aaacagttct caatttcctt ttttaactct ggtgtcaaac gagattttcg acctttttgt
    19141 ttagccttgt ggtcgtactg ttcctgtgct aaggctgcag aataaccatt ttgacatcgt
    19201 tttaactctc ttgaaatggt aaacttatgg acgccaagtt tacttgcaat ttggcaaggt
    19261 ttcaatccta attctaagta ggtttctatc gttattcggt cggttatggt aagatgggag
    19321 tagctcatag tttttcctcg ggttcttttg tgtggttact tacagtttac accaatgaaa
    19381 cgctatgagt ttttttgttg cactatattt tacaatttat cataaaataa ataaaaagac
    19441 agatatcttt cattttagat agagtaagat taaatccttt atggagtaga ggtatctacc
    19501 tatagtgatt tttattacaa ttctgaagga gttatgccat gcttaacatc tatgttttag
    19561 aggatcattt tatccaacaa aatcgtattg aagaggttat tcatacggtt cttaagaaaa
    19621 ataacattaa agtaggcgac tttgaggttt ttgacaaacc caatcagcta ttagagtcta
    19681 ttaccgagcg agggtctcat cagctctttt tcttggacat tcaaattaaa gacgatacta
    19741 aaaaaggttt ggaagtggct aagcagattc gcaagaatga tccctatgcc aatattgttt
    19801 tcttcacgac ccattcagag tatcttccct tgacttttca ataccaactg gcagctctag
    19861 actttattga taagtctttg gagggtgagg actttcaaaa gcgtgtggaa agtattatct
    19921 tattaacctg caaaaagata cagagtcaga atccagaaga tgcttttcgg attgagaatg
    19981 ttaagaccgt tattcaggtt ccctttcatg atatcttgta ctttgagacc tcggatatcg
    20041 ttcataaggt tatcctttat actaaagagg agcaaatcga gttttatggc agtctctctc
    20101 aaattgaaaa gagtgaccct agactgttta aatgccataa atctttcctt atcaacccag
    20161 aaaatgtcat caaattagat aaaagtacgg ggacggtcta ttttgaaaac ggtggtatct
    20221 gctatgtttc aaagttgaaa ctaaagaaat tgcttgagag aattagccta tgacagcaat
    20281 caattttgtg ttggataatc tagacttttt agtggagatt atcctcttta ttctcattta
    20341 tcaatacatt acctccgaga agataaagct aagatggtat atcatcatcc ccttgattat
    20401 gcgatttttg tttgtgcttt ctccagcact atcctatgtt atagggcatg ccttcttggt
    20461 tgtttattcc ctctacagaa atcgttatgg caataggtta ttagatattt tctatggctt
    20521 gtttccaatc atcatagaaa gtcttgttca caatcttatt atttatggga ttgccttggt
    20581 catcaatcgt cattatctga ttgtacttaa ccattttcat ttaaaccttg tcattgagtt
    20641 gctagtcttt cctgtgtttt ggttaatcat taagacctta aaagtggatt tcaaagcatt
    20701 gaactatggt tttcgaaagt cattttcaaa gtacttttta ttactcatag atatatcaat
    20761 gttatcttat gccctccttc tccaatatat tacctttttt gtgcaacaga gccctggagg
    20821 aagagattgg catgtttatc tcgtggtgac ctatgcttta ctctttcttg cgacccttgt
    20881 ttatatcaat gcgaccttca gtgagagact aaaagaagaa gtcatactcc aaaaagatag
    20941 gcaaatgagt gatttggctc attatagtca acaaatcgag caactctata cggatcttcg
    21001 tcgcttcagg cacgattacc taaatgtttt gtctagtatc aaatatggca ttgactccaa
    21061 ggatatggct attatttccg atatctacga taacatcctt gaaaaaacaa agactcggat
    21121 tgaggggaaa cagtacgaaa ttgccaactt gattaatatt aaagatgaag ccgttaaagg
    21181 tgtcctggct agtaaaattt tggaagcaca gggacagtct attaccattc accttgaggt
    21241 cagtgatatc tttgaaatat cgaggatggg attgttggat ttcataacag tgctgtccat
    21301 atttttggat aatgctattg aagctagtct ggatagcagt actaaagaag taaacattgc
    21361 tcttatcagt ggagagacaa aggtagtaat agtagagaat accattgctc aagaatctat
    21421 caatacagtc ggtatcttta aacttggtcg ctcaagtaaa ggagagggac gtggtatagg
    21481 tctgtccact gttcgagaga ttttagggaa gtaccctaat tgttctttgt caacacaatc
    21541 taaagactat cgttttaaac agacgctaaa aatagaagat gtggtttgat tatgacgaaa
    21601 aaacgactgt ttatgacttc aatgaaaaat ttagctttct atatattata ataacctcgt
    21661 aaattatcag aaaaggaatc tcactcatga aaaatacaag taaacttatt ggtatcctat
    21721 cagctctaat tgtagttatc cttgctgtct tcttggtgac taagtttaat agtcatgagt
    21781 cggcgcgtgt tagcacaagt agtagcccgg ctaagacggt caagaaatca tcttcaagct
    21841 caagtaaagc tgttaagaag gataagaaaa attcaaaccc gcatgtaaaa agtgaagaca
    21901 cagaagatac aacagttgag gttagtgagc cttctgttgc caaggattct gcaactaaag
    21961 atactaatga aacggtctta tcttcaggaa gtgtttctga gactacaaaa gaaaaaacag
    22021 gagaagaaac acaaacatca tcattaaatg ggaaccaact aagttcaggt gattatagtt
    22081 caatcgctgg tacttggaca aactctcgag gagaatttgt cacaatttcc ccagatggga
    22141 cagtacaaaa tgggagtggt tatacttatc atctctattc tggacattta aataatggaa
    22201 atttttcagg aacaattgct tctgatattg atagcgcagc tttttgggct attcctggaa
    22261 ctggtaatgg cgattcagac catcttgtta ttggtcaaag tgatgatgca gaaaattatc
    22321 cattttatcg taattaacat gaaaaaagat tgctatttga atagtgatct ttttatattt
    22381 tttccacttt tcctaacaaa attacgaata aataagtatg gcttgcttcg gctttcgatt
    22441 atgacaaaaa atggacagtt tatgatttag gtgtgaacaa gtcaaataaa tttggtatac
    22501 taatggacaa gtgagaaata ttcagtaata ttctgtaaaa tacttgtaat gtttgtcacc
    22561 gagtgttaca atcaaacagt aacatcaatt cgatagagag aataattgat atgaaacgag
    22621 aaaaattttt acacgaacaa caacgttttt ccattcgtaa atattcattt ggggcagcat
    22681 cagttctttt aggagctagt ttggtctttg caggtcaagc tttggctgat gagcatcatg
    22741 aagtttcaac accttcagat gccactgtgc gtgctacctc agatagtgat gctgtgacag
    22801 cagctgatat tttcagtggg gtagcatcaa gtgagaaagc tagccaagtc tcaacaacta
    22861 gccaaaccgc tagtggaact gctactagcg aggctagaag tgaagtgagt gctagtacct
    22921 cacaagcagc agataaaatt tctgaatcaa caactgctag ctcagaagcg acaaggaaca
    22981 caaatgcttc atctgaaaca gccactaacc ttgatgtatc tgccttaacg agagcggctg
    23041 tcaacactag tttggtgagc caaccagcta caactacaga cagcgacctt ccaagtcaag
    23101 gaacttatgt ctacaaggaa cgtacagaga ttaagaatca acccaaggtg tctgccaagg
    23161 ctgaatttta tgtaaatcca ggagacagcg tcctttacga tcaagtcgtg acggctgacg
    23221 gctaccaatg gattagctac aaatcatact ctggcgtgcg tcgttatgcg ccagtgaaac
    23281 cagtggcagc tggtagtggt aatggtaata gtggtaatgg ggatggcaaa ccttctaatg
    23341 gcgctcaagc cacaacaggg gctttgaaca tcccagcgac aggaactttc tactttacac
    23401 gtgacacaga tattaagaaa gaaccaaaag cagacctcaa acctactttt gttttcagta
    23461 agggtgacca tgttatctat gacaaagttt tgactgcgga taatcaccaa tggatttctt
    23521 accttggtta tgactatgtt cgctattatg cagatgttgc gactttgaca cctgctaaag
    23581 ctgaaacacc aactgttaaa ccaacagaga ctaatcaagc aaaaccagaa actactggtg
    23641 ctgaaaagct tccagcaagt ggtacttata atgtgacacg tagcttgaat gttaaaaacg
    23701 aacctaaagc ttctgcagaa acactttata ccttggaaaa aggctacaaa gtgaactatg
    23761 acaaggtctt gactgcggat aaccatcaat ggatttctta catcagttac agtggtacac
    23821 gtcgttatgt ggatattgcg accttgaaag ctactgagtc taaaccacaa gaaaaccgtg
    23881 tttctggtaa ccttaccatc aacaaccaaa cctctaatgg ctttgatgtt gtcgtaacca
    23941 atgtttcagg tggtggcaag acagttcagg aagtccgtgt tccaatttgg tcagataaag
    24001 atggtcaaga tgatctcact tggtatcatg ctgacaaaca gtcagacggt agctataagg
    24061 ttcatgtaga tacagctagc cataagggtg atacgggtac ttattctgtg catctttact
    24121 atatgttgga tggtaagcga acttatatta ccgaaactac agccaaagtc cctgaaactc
    24181 aagtaacagg aaaattgacg attaccaacc aaagctc
//
