LOCUS       NZ_CP046591            21612 bp    DNA     circular CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain R31 chromosome, complete genome.
ACCESSION   NZ_CP046591
VERSION     NZ_CP046591.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4186822)
  AUTHORS   Yu,G.
  TITLE     Study on the banana fusarium wilt control by endophytic Bacillus
            subtilis strain R31 by regulating banana rhizosphere microbial
            community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4186822)
  AUTHORS   Yu,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2019) Institute of Plant Health, Zhongkai
            University of Agriculture and Engineering, Dongsha, Guangzhou,
            Guangdong 510000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 450.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015602625.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:59:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,377
            CDSs (total)                      :: 4,256
            Genes (coding)                    :: 4,150
            CDSs (with protein)               :: 4,150
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 67 of 106
            Pseudo Genes (incomplete)         :: 47 of 106
            Pseudo Genes (internal stop)      :: 16 of 106
            Pseudo Genes (multiple problems)  :: 19 of 106
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:59:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3053785
            Orig. end                         :: 3075397
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP046591.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21612
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="10"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..21612
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21612
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11612](-)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11612)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     misc_feature    complement(348..357)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    379..392
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.88"
                     /tool="antismash"
     gene            complement(421..540)
                     /gene="phrF"
                     /locus_tag="GO004_RS15905"
                     /old_locus_tag="GO004_15895"
     CDS             complement(421..540)
                     /codon_start=1
                     /gene="phrF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391627.1"
                     /locus_tag="GO004_RS15905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15895"
                     /product="phosphatase RapF inhibitor PhrF"
                     /protein_id="WP_009968329.1"
                     /transl_table=11
                     /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI"
     gene            complement(524..1669)
                     /gene="rapF"
                     /locus_tag="GO004_RS15910"
                     /old_locus_tag="GO004_15900"
     CDS             complement(524..1669)
                     /codon_start=1
                     /gene="rapF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391626.1"
                     /locus_tag="GO004_RS15910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15900"
                     /product="response regulator aspartate phosphatase RapF"
                     /protein_id="WP_015714890.1"
                     /transl_table=11
                     /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLNLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFSMDY
                     ARQAYEIYKENEAYNIRLLQCHSLFATNFLDLKQYEDAVSHFQKAYSMAEAEKQPQLMG
                     RTLYNIGLCKNSQSQYEDAITYFKRAIAVFEESNILPSLPQAYFLITQIHYKLGKMDKA
                     HEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYADLEDFA
                     IDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV"
     gene            1672..1902
                     /locus_tag="GO004_RS21970"
                     /old_locus_tag="GO004_15905"
     CDS             1672..1902
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009968328.1"
                     /locus_tag="GO004_RS21970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15905"
                     /product="hypothetical protein"
                     /protein_id="WP_015714889.1"
                     /transl_table=11
                     /translation="MQIPPFIILYMSYFIINILVRSAKKPQFFLSLHRMFGDIFSKRSV
                     YPQQFVQANTLVFHILLYLREQCMSEKEVKE"
     misc_feature    complement(1702..1718)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.81"
                     /tool="antismash"
     gene            1899..3254
                     /gene="ywhK"
                     /locus_tag="GO004_RS15915"
                     /old_locus_tag="GO004_15910"
     CDS             1899..3254
                     /codon_start=1
                     /gene="ywhK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391625.1"
                     /locus_tag="GO004_RS15915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15910"
                     /product="YncE family protein"
                     /protein_id="WP_195727704.1"
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISDITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANPNDQSVSVIDTNTHTVVTTIALPYNPAGIEITPDKSAVFVLHPNNNV
                     ISVIDYDTLTVTATILLDQPPRLISFIPNHEFAYVFTGTVVYVIGIDTLTVDRSIPVEG
                     YDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAYVLEQEF
                     FFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPNGAGVIGN
                     VPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAITI"
     gene            3293..4669
                     /gene="ywhL"
                     /locus_tag="GO004_RS15920"
                     /old_locus_tag="GO004_15915"
     CDS             3293..4669
                     /codon_start=1
                     /gene="ywhL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391624.1"
                     /locus_tag="GO004_RS15920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15915"
                     /product="YncE family protein"
                     /protein_id="WP_003244415.1"
                     /transl_table=11
                     /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEAS
                     AAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGDGA
                     VSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSPDPQ
                     SYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLVSVID
                     NKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPGALDFA
                     LDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYVLNGELW
                     PKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTAR
                     QRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVGAGPSAIAM
                     "
     misc_feature    complement(3309..3326)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(4675..5376)
                     /gene="albG"
                     /locus_tag="GO004_RS15925"
                     /old_locus_tag="GO004_15920"
     CDS             complement(4675..5376)
                     /codon_start=1
                     /gene="albG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391623.1"
                     /locus_tag="GO004_RS15925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15920"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbG"
                     /protein_id="WP_195727705.1"
                     /transl_table=11
                     /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSFIYKR
                     FSYRSTASLDL"
     gene            complement(5373..6653)
                     /gene="albF"
                     /locus_tag="GO004_RS15930"
                     /old_locus_tag="GO004_15925"
     CDS             complement(5373..6653)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="albF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391622.1"
                     /locus_tag="GO004_RS15930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15925"
                     /product="pitrilysin family protein"
                     /protein_id="WP_003242974.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 2.6e-13, bitscore:
                     48.2, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKLYWDIA
                     ARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHIIQDMDAQ
                     VFLSLIDAMASSNKAIIHVSQKEAIRQ"
     gene            complement(6658..7818)
                     /gene="albE"
                     /locus_tag="GO004_RS15935"
                     /old_locus_tag="GO004_15930"
     CDS             complement(6658..7818)
                     /codon_start=1
                     /function="16.4: Excrete"
                     /function="16.8: Protect"
                     /function="16.5: Explore"
                     /gene="albE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391621.1"
                     /locus_tag="GO004_RS15935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15930"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbE"
                     /protein_id="WP_010886633.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 4.4e-05,
                     bitscore: 21.5, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYLK
                     EQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSFPS
                     SLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKAIHP
                     KRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFETETRS
                     AAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHVITRYD
                     VMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQFDSPEGL
                     LAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     gene            complement(7808..9118)
                     /gene="albD"
                     /locus_tag="GO004_RS15940"
                     /old_locus_tag="GO004_15935"
     CDS             complement(7808..9118)
                     /codon_start=1
                     /gene="albD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391620.1"
                     /locus_tag="GO004_RS15940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15935"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbD"
                     /protein_id="WP_003243158.1"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     LMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFISGRSIS
                     VLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPLFLAILAG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     gene            complement(9111..9830)
                     /gene="albC"
                     /locus_tag="GO004_RS15945"
                     /old_locus_tag="GO004_15940"
     CDS             complement(9111..9830)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="albC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391619.1"
                     /locus_tag="GO004_RS15945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15940"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_003227564.1"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     gene            complement(9827..9988)
                     /gene="albB"
                     /locus_tag="GO004_RS15950"
                     /old_locus_tag="GO004_15945"
     CDS             complement(9827..9988)
                     /codon_start=1
                     /gene="albB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391618.1"
                     /locus_tag="GO004_RS15950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15945"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbB"
                     /protein_id="WP_003222006.1"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGM
                     RARKADSR"
     gene            complement(10001..11347)
                     /gene="albA"
                     /locus_tag="GO004_RS15955"
                     /old_locus_tag="GO004_15950"
     CDS             complement(10001..11347)
                     /codon_start=1
                     /gene="albA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391617.1"
                     /locus_tag="GO004_RS15955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15950"
                     /product="subtilosin maturase AlbA"
                     /protein_id="WP_088467433.1"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1077.7, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 5.2e-29,
                     bitscore: 98.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-07, bitscore: 28.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2.6e-44, bitscore:
                     149.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.2e-06, bitscore: 26.1,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.5e-21, bitscore: 75.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.3e-10, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.7e-09, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLN
                     KTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRASR
                     HTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKMADMLFDN
                     GVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQKIIVG
                     ISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKV
                     RDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPIIPYERKR
                     AANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRF
                     SEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI"
     aSDomain        complement(11057..11332)
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GO004_RS15955_Subtilosin_rSAM_RRE.1"
                     /evalue="3.40E-31"
                     /identifier="RREFam018.1"
                     /label="GO004_RS15955"
                     /locus_tag="GO004_RS15955"
                     /protein_end="97"
                     /protein_start="5"
                     /score="98.4"
                     /tool="antismash"
                     /translation="MFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLNKTAYE
                     LCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQ"
     gene            complement(11372..11524)
                     /gene="sboX"
                     /locus_tag="GO004_RS15960"
                     /old_locus_tag="GO004_15955"
     CDS             complement(11372..11524)
                     /codon_start=1
                     /gene="sboX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_054594.1"
                     /locus_tag="GO004_RS15960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15955"
                     /product="bacteriocin-like protein SboX"
                     /protein_id="WP_010886632.1"
                     /transl_table=11
                     /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIHT
                     QPFFI"
     gene            complement(11481..11612)
                     /gene="sboA"
                     /locus_tag="GO004_RS15965"
                     /old_locus_tag="GO004_15960"
     CDS             complement(11481..11612)
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="sboA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391616.1"
                     /locus_tag="GO004_RS15965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15960"
                     /product="subtilosin A"
                     /protein_id="WP_003222002.1"
                     /sec_met_domain="Subtilosin_A (E-value: 9.2e-29, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       complement(11583..11612)
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="GO004_RS15965_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       complement(11481..11582)
                     /prepeptide="core"
                     /locus_tag="GO004_RS15965_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="33.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[11582:11612](-)"
     misc_feature    complement(11703..11718)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.99"
                     /tool="antismash"
     gene            11925..12353
                     /gene="ywiB"
                     /locus_tag="GO004_RS15970"
                     /old_locus_tag="GO004_15965"
     CDS             11925..12353
                     /codon_start=1
                     /gene="ywiB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391615.1"
                     /locus_tag="GO004_RS15970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15965"
                     /product="DUF1934 domain-containing protein"
                     /protein_id="WP_003243604.1"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     gene            12350..14020
                     /gene="argS"
                     /locus_tag="GO004_RS15975"
                     /old_locus_tag="GO004_15970"
     CDS             12350..14020
                     /EC_number="6.1.1.19"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391614.1"
                     /locus_tag="GO004_RS15975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15970"
                     /product="arginine--tRNA ligase"
                     /protein_id="WP_003227570.1"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALRE
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     misc_feature    complement(14076..14091)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            14156..15343
                     /gene="narK"
                     /locus_tag="GO004_RS15980"
                     /old_locus_tag="GO004_15975"
     CDS             14156..15343
                     /codon_start=1
                     /gene="narK"
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391613.2"
                     /locus_tag="GO004_RS15980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15975"
                     /product="nitrate transporter NarK"
                     /protein_id="WP_010886631.1"
                     /transl_table=11
                     /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEIS
                     LVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGGFF
                     LGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKSTVQ
                     MYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAFVAFT
                     IYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFAGLTLS
                     GIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAMGGLGGF
                     FPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQSIN"
     gene            15442..16158
                     /gene="fnr"
                     /locus_tag="GO004_RS15985"
                     /old_locus_tag="GO004_15980"
     CDS             15442..16158
                     /codon_start=1
                     /gene="fnr"
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391612.1"
                     /locus_tag="GO004_RS15985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15980"
                     /product="fumarate/nitrate reduction transcriptional
                     regulator Fnr"
                     /protein_id="WP_003227573.1"
                     /transl_table=11
                     /translation="MNFLSVRPSDSDLISSDLHELLESISTKRKMEKHTYLFREGMDAE
                     ELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEVLV
                     INKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSNSYG
                     VERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKRDYLR
                     CEIECENCPLEICNID"
     gene            complement(16190..16909)
                     /gene="ywiC"
                     /locus_tag="GO004_RS15990"
                     /old_locus_tag="GO004_15985"
     CDS             complement(16190..16909)
                     /codon_start=1
                     /gene="ywiC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391611.1"
                     /locus_tag="GO004_RS15990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15985"
                     /product="YwiC-like family protein"
                     /protein_id="WP_014481214.1"
                     /transl_table=11
                     /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYLA
                     VYPVTLALKKKQSKPYQKWMCYYGFPACCFLMISVFHKPPLIWVGVSLLPLFLIHMYFA
                     RRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVKSVI
                     RERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTIGILE
                     IVNACFFLAVMCLFITR"
     misc_feature    16980..16995
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            17053..17529
                     /gene="arfM"
                     /locus_tag="GO004_RS15995"
                     /old_locus_tag="GO004_15990"
     CDS             17053..17529
                     /codon_start=1
                     /gene="arfM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391610.1"
                     /locus_tag="GO004_RS15995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15990"
                     /product="Crp/Fnr family transcriptional regulator ArfM"
                     /protein_id="WP_003243032.1"
                     /transl_table=11
                     /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSFL
                     HSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSDIL
                     ILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS"
     misc_feature    complement(17621..17635)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.64"
                     /tool="antismash"
     misc_feature    17622..17635
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    complement(17644..17659)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            17725..21411
                     /gene="narG"
                     /locus_tag="GO004_RS16000"
                     /old_locus_tag="GO004_15995"
     CDS             17725..21411
                     /GO_component="GO:0009325 - nitrate reductase complex
                     [Evidence IEA]"
                     /GO_function="GO:0008940 - nitrate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009061 - anaerobic respiration [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="narG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391609.2"
                     /locus_tag="GO004_RS16000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_15995"
                     /product="nitrate reductase subunit alpha"
                     /protein_id="WP_019712380.1"
                     /transl_table=11
                     /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRWQ
                     YDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGASFS
                     WYIYSPLRVKYPYVRGVLINLWREALQEHQNPLEAWKSIVENPEKAKSYKQARGKGGFV
                     RAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPMLSFY
                     DWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEARYKGAK
                     VISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEYAKQYTD
                     FPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGTMGSRWDG
                     QQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLPIKKMNLNG
                     EETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKEAVVKIAREF
                     AQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGWAHYVGQEKLR
                     PAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPIAASSRYKHHAD
                     YNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQLQEKKLKFAIEDP
                     DNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDSIRPEEIKWREQAP
                     EGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFIHPFAPAISAPWESK
                     SDWDIFKALSKAVSDLAEEVNMEPVKEVVATPLLHDTMQELAQPFGKINDWSKGECEAI
                     PGKTMPNIQVVERDYKHIFHKMTALGPNAALKPSGTKGMSWSIADEYESLKQRLGEITS
                     DSVAKGCPNISEAKQAAEAVLTLSSTSNGKVAVKAWESLENITNLKLKDLAEEREEECF
                     TFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPWRTLTGRQTYYVDHELMME
                     FGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKWSVHSMYFDSLPMLTLFRGG
                     PTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHRIPKGMAFMHHAQDRHINVPG
                     TKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYYGPTGNQRDLNVVIRKLKEVDW
                     LED"
     misc_feature    21489..21503
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.21"
                     /tool="antismash"
ORIGIN
        1 gcagttgtat agtcgtaagg gctgtaccat ctgaaagtaa aatgcaccct tgaatcgctc
       61 gtatttgctt ttgcatgaac cgcctgtgta acacccagtg aggaaactgc gatcccaaac
      121 atgatgatga gtaaactaat cctttttttg aattgaactt tcaaaataaa tcctccattt
      181 ttaaactcca attgaagtga tactgaactt aagtcatata tatattagtt caaaaaaaag
      241 gaaaagtaaa catattttta ttttttcata taatgaaaat tatcttgttt cctatgtttg
      301 tgggtgaggt aaccaattta aattagtaag taataatatt tagagattca aaaaataaaa
      361 cttttgtccc gattgtgtat ttaacaaaaa aaaacaaccg atgaaaaccg gttgtattca
      421 ttaaatcatt cctcgttgtg caacttcaat ttggtgtgta ggtgcatttg caatagttgt
      481 tgccacgaac acagtgctta gagccagaca agagagtaat agtttagact tcaatttcat
      541 acaaactcac tcctccttga ataagttgcc ttacttgttc caccttcaaa aaataagcag
      601 aagctttttg aaaattttta cgttcatgat aatattttgc cacatcaata gcgaaatctt
      661 caagatcagc atacaacatt ttactttcga gaaaatcaaa aaatccttga attgcttctt
      721 catccgggcc tgataagtat aaagatttca aaaattcaaa ctctgataaa tatattacat
      781 ctccggcctt ttgtgaataa gccattccct tactatgata ttcatgagct ttatccattt
      841 ttcctaattt ataatggatc tgtgtaatta aaaaatacgc ttgaggtaag gaaggaagaa
      901 tatttgattc ttcaaaaaca gctattgctc ttttgaaata agttatggca tcctcatatt
      961 ggctttggct gtttttacaa agcccgatat tgtacaaagt tcttcccatt aattggggct
     1021 gcttttcagc ttctgccata gaataagctt tttgaaaatg tgagacggca tcctcatact
     1081 gttttaaatc taaaaaattg gtggcaaata aagaatgaca ctgcagcaat cttatattat
     1141 aagcttcatt ttctttgtat atttcatatg cttgccgtgc atagtccatt gaaaaatacg
     1201 tttgtttcat atagtaataa gattcagaca tcttaaagaa aaactcagct ttctctatcc
     1261 gatccttaac gaatatcagc ttgctttcgg cctttttgaa aaatttaata gccgacagat
     1321 attcccgctg gtccagctca tacatgcctc tgaagaaatt aaaatagtac tcaagcagac
     1381 cagttaaacg agcctgtttt ttatcaatct caagcagcag atcagacagt ctcggctgtt
     1441 cctcaatcct cattttttct aacggttcaa ggtactcaag catcaggttg tgccgaaact
     1501 ccatcagtga atagtacaaa ttaaggtctt gatcttcttc catttgatcc agctcttgct
     1561 tgatttctcg tcgcaaatat tctgcatcgg gtatgctgaa tcggcgtatg tacatatacc
     1621 attcgttaat cttttctccg atggaagaag aagatatgac acctgtcact tttgcaaatc
     1681 cctcccttca taattctata tatgtcatat tttatcatca acattcttgt gagaagcgca
     1741 aaaaaaccgc aattttttct ttcgttacac cgcatgtttg gagatatatt ttcaaaaaga
     1801 agcgtttacc ctcagcaatt tgtacaagca aacacgttag tcttccatat tctgttatat
     1861 ctgcgtgagc agtgtatgtc tgaaaaggaa gtgaaggaat gagaaaaaac aagctttcct
     1921 ttaaagaaaa agcaggagca gaacaagaag agtgcttatg tttttgtgag ggagaagcaa
     1981 gccgagaagc catgtttcaa gcgccgattg aattacctga aggatttgtc gttgatccgg
     2041 ctgaagctgt tgcaaacgtg acgtggaatg cagacagcct ttcttgtgtc agtgaccgtt
     2101 gcttaattca aacggggcca gagcctgatg aggtcggtgt tcaatttgca gtgcgcctgc
     2161 agggaaccgt tacgctactc gtcagtgtct cacctgtgcg aaatcaatat ggacaagggg
     2221 acggggctgt ttccgtcatt cacaatgcag aaatcgatca agtcgtctat tattccgatg
     2281 aaccggatga ttgcccggat atcagtgaca tcacgattga gaaccttgtt gttgttccgc
     2341 cgttttacgg cagtccttta tcggtgacgg ggacgattgt gcttgtaccg gagccggaac
     2401 ccgtctacgc gtttacagcg aatccaaatg atcaatcagt ttctgtgatt gatacaaaca
     2461 cccatactgt tgtgacaacg attgctcttc cgtacaatcc ggcaggtatt gaaattacgc
     2521 cagataaaag cgctgtgttt gtcttacatc ccaacaataa tgtgatttct gtcatcgatt
     2581 atgacacatt aacagtgaca gcaactatat tgctggatca gccgcctcga ttgattagtt
     2641 ttatccctaa tcatgagttt gcttatgttt tcaccggtac tgtggtttat gtgattggaa
     2701 ttgatacgtt aactgtggat aggtcgattc ctgtggaagg atatgatgtt gcaatcgatc
     2761 ccaatgggtt attcgcctat gttctgaatt ttggaatagt gcaaaaagtg gacctaacta
     2821 ccggtgaagt cacaggaaca attgaacgag agcttatcgt atcaaccata gaaacaaatt
     2881 ggccggagcg gtatgcctat gtattagaac aagaattctt ttttaattat ttgacggtta
     2941 ttgatttaaa tacgtttacc atcagcagca cccaagagct ggagtatgaa ggggaatatc
     3001 gaatgtttac gagtggagca gaggtgtatt tatatgacgg cttcactggc aatttatatt
     3061 ctgtcagtcc aaatggagca ggcgttatag gaaatgttcc gcaatcagca acagactatg
     3121 cgtttacccc gaatggcgat tttctgtatg caactcgttt tatagagcag agcatcattg
     3181 tttacaacac agatgattat tctgaggaaa ctgtgatatc tcttggggtt tcaccgggtg
     3241 ccattacgat ttaaccgctg catgttgtgc atttctaaaa ggacgtgaaa tcatgaaaaa
     3301 gaatgatctt tctgctttac aggaaaattg tttctgtttt tgtgatgagg aaattagccg
     3361 ggaagcgccg tttcaagtgc cgatagattt ccctgagggc ttcaaggttg atacggccga
     3421 agcgtcagcg gctgttacat ggagtacaga caatttgtcc tgtatcagtg agccttgctt
     3481 aatccagact gggccggaac cagaagatat cggtgttcga tatgctgtga gagtacaagg
     3541 gaccattacg cttcttgtca gtgtgtcgcc tgtacgaaat caatatggac aaggagacgg
     3601 ggctgtttct gtgattcata ctgaagagat tgatcaagtt gtttattatg cagcacagtc
     3661 tggccgctgt cctgatttca gtcaaataac agtggaagat ctgctcattg taccgccttt
     3721 ctacggcagt ccgcttacgg tggccgggac acttgtttta ccgccatcac cagaccctca
     3781 atcgtatgtg tttactgcca atactggaga cagcacggtt tcggttattg atgcagattt
     3841 aaacactgtt gtaaaaacaa tccctttttc tgacgtgcca actaatctag gcgttacttt
     3901 cgataaagca ttcacgtatg tcctccatgg aaataccaac cttgtctcag tgattgataa
     3961 taaaacatta accatcataa ataccattac tgttggagga gggccgagaa aaatcgaatt
     4021 tgatccaaca gatgagttcg catacgtgat ggccgccgga tctatatatg tgattaacac
     4081 ggcctctcaa tcggtcattg atgtcattcc gatacccggc gctttagact ttgctcttga
     4141 tccgaatgga cagtatgtct ataccgctaa tggaagcagt tggtcggttg ataaatatga
     4201 tgtaaatact gggcagttgg tagaaagtat catagataca tttgaatttc ccagtttaat
     4261 tacaactcct tacgctggaa attttgcgta cgtattgaat ggtgagctgt ggccgaaagg
     4321 tgtaacggag attagtttgt caccattaag caggggaggg gacttcagcc gtttatttga
     4381 aacgctgagg acgattgtat tttctctcga tagtactaga gcttattttc tagagccata
     4441 tagtgaaccg tttctcatta ataacttata cgtagttaat acggccagac agaggatcat
     4501 tgcaaacgtg tctctccccg gcgcctttga cctcgccgta acgccggaca aacagtatat
     4561 ttatgcggca cagcccaacg acaatgctgt gaccgtgtac cgcacaagtg attatacagc
     4621 cgtgacggtg attccggttg gcgcgggtcc gtctgcgatt gcgatgtagc tattttatag
     4681 atcaagagaa gcggtgctgc gataagagaa tcgtttataa ataaatgatc cgatttgctg
     4741 aatggcagcc aggataatca gaaacagcag ttcacttata gagaaactga gcatccacca
     4801 aatcccggct gctgccagtg ctcccgcaaa cacttttctg aacaggctgc cgtgccggaa
     4861 aagctgccgc aaatacgttc gcatgcaaaa caataaatac aggatcagta gcatcgcaag
     4921 tcccattgaa aaggcagggg gcgtatgaag gcggaaaggg acggctttaa cgatttcgaa
     4981 catgcagccg aatatgatga cttggcacaa cacggcagcc atcacgtatg tttggcggac
     5041 gtttttatag ctgtcacgca gcgatttgac gtcttctgca tatcggctgc acaagttgtg
     5101 ttgctgaaag tcacagcagc tttgatgaga ctgtgtgagt ttctgaaaag ctgctgtcat
     5161 gtttttcacg gattgggtga catagtgaag atagagaaaa gcaggcagca tcaggagggc
     5221 agcggtacaa gccagcagtc cgagccgcac agcatcattg ttgatcatct gtacatattg
     5281 ggcggcggct tcggcaacgg cctgaaccca gccgaaggaa taagccgcca tacctataag
     5341 cagcaataaa agggtaaaga cagtgctttg tttcattgtc tgatcgcctc tttctgagaa
     5401 acgtgaatga tcgctttgtt agaagatgcc attgcatcaa tgagagacaa gaaaacctgc
     5461 gcatccatat cttgaatgat gtggtacatg tcaagaaacg agcaatcgca cctgtcacac
     5521 tcggctgccc actcgaagca tttacgcaca taatcgctgt cataaatgat cgcgtctgtc
     5581 aaagagtcct tgccgtattg aagccaggcg gcaacctgtt ctttcttctg tgtgacatag
     5641 tatgaagcca catcgatata agctgaagaa tgggtccctt gactgtgaag gatcaagaaa
     5701 ccgccatcct catatatata agtctcggct gacaagcgat cgatttccag gcggtacgtt
     5761 tgctgaatct cttgaaaaaa cggtgaatct aattgaaata gaatacgagc cgcgatatcc
     5821 caataaagct ttatcgacaa cagatcgttt tgcccgggaa gtgcgccgat ctgtaatccg
     5881 gtccaggtat cttccatccg ctcctcatca cccagcatca ttttttgtga gaggactgga
     5941 gggcatgccg ggatgatttt tctttcagca tgataatccg gacgcttttc cagctggagg
     6001 tgaggaggca aaagcgtttc tgtattttct gagcccccaa tcaaaaacag cgtcatccga
     6061 tgggcttggt aggcagcctt ataggctttt tgtaaatcac tgatgtccag cgcctcaata
     6121 tcttcgattc tgcctgcggg gaaaacggca gctggtgagg agggagaaag catgctgatc
     6181 agctgataat gatatgagag ctgatggtta aggtgtgctg tttgaatttc gcttgtaatc
     6241 acagcttttt cctgagcgac aatcttcttg tcaaatgagt ggttccataa agcatcaagc
     6301 aggatgggaa tcgtttgtct gagccgatcc ggtaatgagg taaacatgaa attggtatcg
     6361 gtgtaggtag tgaatgcgtt taaaagcgcg ccatgcgcaa aaaaatcact gtacagattg
     6421 cggccgttat gccagaagag aagatgctct aaaaaatgtg ctgtgccata cggaagcagt
     6481 gtatcaccgg attctgcccg tatacataca tcccggcttc caaaatcgat ttttacattg
     6541 cacagccgca ggtgggcgcg ggggaatttc aatctgaata tttttagtcc gctgtctgtg
     6601 tatctgatat cggttcgttc atccagctgt tgaaaaaagg ctttcttttc catctcttca
     6661 tccccttact acatgagctc cgatataatt gatggtcgct atgaattgca atacatcacg
     6721 gcatgtaacc gctgagatgc catccagcaa ggcttctttc gtgcaggaga agcggcgcag
     6781 gacccccata taggccaata gaccttcggg agaatcgaat tgcagcagca attcattgcg
     6841 taaaaactgc tttgcctgtt ctagttcccg ctcatctgta tgaaaagctg agacagcttc
     6901 caaaacgcgc gggggaatgt ctttctcatg aagctgatct gtacatattg aaacaagcag
     6961 caaattgttc atgacatcgt aacgggtgat aacgtgatag actgccagat ccttctctct
     7021 gaagtgcttg aataaagcgg aatggccgta ctttcccagt aatccgtcta ttagctgtat
     7081 tttgatataa tcgctggcat ctttcatctc tccgcagtca aatccgagtg tcaagacgga
     7141 aggacctgca gcgctgcgtg tctctgtttc aaaaacatgc cggtttacgg gtattcttcc
     7201 ggacgttaca gcggacgttt gcggggcatg tccccgaaca tcacatgctt gtacttgtcc
     7261 caatatgttc agctgttttt gctgggacac taaatcaacg ataaagtccg ttgcgtcgag
     7321 aaaccgttta ggatgaatcg cctttatcct gtctctccgg ccaaacatgc ctgtgccgta
     7381 catcgggttt ccgaagacct cctcagccaa gcgagccgcc gagtaggaga agggatcagt
     7441 gaatttcttt tcgattttca gcagcagctc attcctggcc ttttcaaatg cttcgaatga
     7501 aagagaagaa gggaaagaca agtctgcaaa agttttcatc agggcgtcaa catgaagatt
     7561 cccgttatat aatgggtgaa tcaaacgggt cccgcaggtt ttcagctgct gatcaaaaaa
     7621 gagattcgct gagtacatga aacggctgcc ggcagcataa ccaaaagcgt caatgatttg
     7681 ctccttcagg tatgcggcgg cgccgtaaaa ataaatcgtt tcttcctcag gttccgccgc
     7741 gctttcgatc ggtttcagaa agctcgcggc gattgaaata gttgaaaatt gatgagtctt
     7801 cagcaggtta acttccaagc cgttctcttt tgcttgtatc aaagaaacca ccatcctgtt
     7861 tttgcaggta atagactatg accagaccgg ctatcggaat gaccgccaag gatacagcgg
     7921 tgccggctaa tatggctaag aataggggaa gacaaaacag ataagaccga tattttgaga
     7981 aaccgctcca tagctgctgc tccgtctgcc agctgaagga gggccttttt tcatccgcag
     8041 ttaacctgat atacgctccc gccagcagca actcaatgca ctgcaaaaaa gtgagaactg
     8101 aaatcgaacg gccgctgatg aaacccacaa tcatcacgac aaggagaaat ccgcctgcca
     8161 ataggcctga ataaaagcga tatttcgccc aaaacatcgt ttttcgcttg atcggaagcg
     8221 tgatgagcag catccggtca tttttttcaa tcgaatacaa aagggcgatc ggcgagcaga
     8281 tgagcaaaag cgcggaaatc acgatataaa tcacttgctg attgaagatg ccggtgttca
     8341 tcatctggaa cgaaaagaag ccgctgaata ccgccattac cgcgtaattt aacagcatcg
     8401 ctttagaaga gataaatcgg ttccattctc ttttgtaaaa cgaaaattca gatcgccgca
     8461 taaatgaatg catcttgccc tgctgcggag gcgcctgcag aaagacagga aagtcaatga
     8521 ccaccgccca caggatatga accgcgcaaa gcggaatcgt ggcggccggc atcaaagcgg
     8581 cgctgataca tacacaggcg aatatcgccg catgcagcag aaacatcaag ttcttctttt
     8641 tgacgaagtg gttgcttagc acaactccga aaataatgga gtaaacggta aaaaacgaaa
     8701 acctgccgag ccaaaacaat gtttgcgccc ctgacagcgt tccgtttcca aataagaaca
     8761 gcggtaaaat aaaaaagaat aaagttcttc tcaaacaggt atcgacaaac aaaacgacac
     8821 tctgggcgag ccaaaagctc cgtgaagaaa tcggcagcag gcagctcagc ttcatataag
     8881 attccttcca ttgtgatgtc acggaaagaa acaccatata tgtgttcatc aaaagaagcg
     8941 cgagtatgat atacgttttg cgcaacaccg attcatcaat gccggcctgg cggatcagcc
     9001 cgatttcaaa cacggccaga atgacaaggc ctgcggcaat gcggatggcg tcctttttcc
     9061 cttgccggct gtaaagctgt ttgaacagca aagacatgat agggattatg ttattcatgg
     9121 ccgatcacct cgaaaaattc ccgccgcaga tcggtctcct ctccaatcgg aatgaccttt
     9181 tggatctgtt tgttgtgaag aatagccgca taatcacaaa atctttgcac gacatcgagc
     9241 agatgagaag aaaacaaaat ggttccgcct gcttcacagt actcacgcat tttctgataa
     9301 aagacctcta tcgattccac atccaaaccg acgagcggct catccaaaat aaacagggga
     9361 gcgcgcagca ataagcctgt catcaataca accttttgcc tgttccccaa ggacagctcc
     9421 gaaattctcc tattgatgta tttcgaaaaa tgaaaggcct cggccaaact ggcaaactgc
     9481 tgctctgaaa aatccttttg ataaagcgaa tggacgaaag acacatagtc cttcgccgta
     9541 atttctgtaa atagcagcgg ataatcggcg gcgaagtaac ggtgagtctt cagctgatct
     9601 gatgttttct gcggcatgcc ggcctccgct tcaattccgc acagtgtaaa acgcccgctg
     9661 aaattgcggt tcacgcctgt cagcgtatta atcagtgtcg tttttccggc gccgtttacc
     9721 ccaagtaacc cgtaaacggc gcctttttct aaatgtaaat ccacttgttc taagatgacg
     9781 ttgtcccgtt cataccaaac ggatacatcg tgtatatcca aaatgctcat cgcgagtcag
     9841 ccttccgcgc gcgcatcccg aacagaatgg caatggcaat gaaaatcagc gtaaacagat
     9901 aatcgctttt gacaaaatag acgactgcgc cgatgacaaa gataaatgaa aggatataca
     9961 gtaaaattct tctttgtgct ggtgacaaat cgtttccctc ctaaataagc tggaccacgt
    10021 cttctaattg ttcatttttc gcccaagagc aaatgttttt ccggtgatat ttgttagagt
    10081 tcagcccttt taagtaacag cctccgcaat agccgctgaa cgggcatttg tctttcatgc
    10141 aatgttcgct gaaccgcggc gcttgcgctt gccacagttt atggacgaga ggggagttaa
    10201 agatgctttc ataggaatca tgaaaaatat ttcccaatga aaattccttt ggaaagaggg
    10261 cgcaaggacg tacttcgccg aacggactga tcacaatgga cttccagcca gcgccgcaat
    10321 ttgccgcgcg ttttctctca tagggaataa tcggaatcag atctttaaac tcatcaatca
    10381 catgttgctc gtattccata aacttgcggt gctgctcggc gtctttcgtt ggatggacaa
    10441 tatccctgcc tcttccgaaa tcgtcaaccc aattgtaaga aaacgccttc gccccgagat
    10501 cccgaacctt ttgggccata tcgtggattt cccacatgtt tttttcgaag acagacatag
    10561 cgactctgac aaatataccg tggtcactca acaattttat cgttttacaa gtttgggcaa
    10621 aagagccttt tctccctcta aaggagtcat ggacctcgga attgacacta tctagagaaa
    10681 tgccgacgat gattttttgc ttgtaagtct tcaaaagctc caggctctct tttcgcatga
    10741 gagttccgtt tgttaagaca gcgacttttt tgaacttttt acacacatag tcaagaatct
    10801 cattggcgtt tggatggaca aaaatttctc cacctgtgat ttcgcatgtc aatacaccgt
    10861 tatcaaacag catatcagcc atttttttga attgctcaat cgacacggtg ccgagcgctt
    10921 caggtgagct ttccaaataa cagtgggcgc atttcaaatt acagcggtgc gtcagttcaa
    10981 aggtggcgtg caggggcatc ggaaattcat tgcttccgct cgtggtgatt gtatggcggc
    11041 tggcccggtt tccaagctga ataacctgct tgttctggag catgttgagc atgtcgtaat
    11101 accaatcttt atggtcttcc ggtgattcat catacactgc acattgctca gctaaaatct
    11161 gctcagctgt tttttggcca tccatgcgca tgcagagctc gtaagccgtt ttgttgagat
    11221 ccaaatactc aaagtcagaa atggagacat tatcgcgcaa gtagtcgatt tctaacacgc
    11281 cgccctcagg aagctggtga actcttacac tttcattaat aaatggaaac atctgctcta
    11341 taaacaaaat accatcccct atacatatga ttcaaatgaa aaacggttgt gtatgtatat
    11401 ccaagaggta gattttagtt aaaaattgta atttacttaa aaagggcata gtagaatgac
    11461 tatgcccttt tgggagatcc ttacccccat agaccgaata gacctgttgc accggcaatt
    11521 tcaaaatcag ggataggacc gtccactaga caagcggctc cgatcgagca tgttgcacaa
    11581 cctttgtttt ctacaatgac agcttttttc ataattgaat cctccctttt tttgtttttc
    11641 tagcagatct atgttgtact tttatcttaa aactatcaaa ttactaattc aatacatata
    11701 ttttgaaaaa aatgtgaaaa agaaatgata gatttcggaa aaatgtaaca tttcctaaag
    11761 gtaattagtg atatgatttt ctcttctata taaggaaatg ctttttatga ggtttatctt
    11821 caaatctgat gagcaatgat ggtaagatag aagcagttga agtttacaaa ccgaatgatt
    11881 atactattca agtcaaagtg gaatgatgaa aaggacgtgt cagaatgaag caagagacac
    11941 cgataacact ccatgtgaag tctgtgatcg aggatgacgg aaaccaagaa gtcatcgaat
    12001 tccgcaccac cggattttac tatgtaaaac aaaataaagt gtatctatct tattatgaag
    12061 aacacgactt aggcaaagtc aaaacgattg tgaaagtaag cgaaggcgaa gtcctggtca
    12121 tgaggtcagg cgctgtcaaa atgaatcagc gtttcgtaac gggagcttcc acaattgcta
    12181 aatataaaat gtcatttggt gagcttgagc tgaaaacaag cacaaaatcg attcaatctg
    12241 atctcgatga agaaaaaggc cgtatcagca tcgcatatga catgcatgtc ggagacgagc
    12301 aggagcattt acataatatg acgatcacgt atgagggagg aactcacgca tgaacattgc
    12361 ggaacaaatg aaggacgtgc tgaaagaaga aattaaagcg gccgttctga aagcgggact
    12421 ggctgaagaa agccagattc ccaatgttgt tttagaaaca ccgaaagata aaacacacgg
    12481 cgactactca acgaatatgg cgatgcagct ggcaagagtg gcaaaaaaag cgccgcgcca
    12541 aatcgctgaa gagattgtcg cccattttga taaaggaaag gcttcgattg aaaaactgga
    12601 tatcgccggc ccgggtttta tcaatttcta tatgaacaat caatatttaa caaagctgat
    12661 tccgtctgta ctggaagcag gggaagcata cggggaaacg aacatcggaa acggtgaacg
    12721 agttcaggta gaattcgtat cagcgaatcc gacgggagac cttcacctcg ggcatgcgcg
    12781 cggggcggct gtcggcgatt ccttgtgcaa cgtgctttca aaagcgggtt acgatgtaag
    12841 ccgcgaatac tacattaacg atgcgggaaa ccaaatcaac aatctggcgc tttctgttga
    12901 agtccgttac tttgaagcac tcggattgga aaaaccgatg ccggaggatg gctaccgcgg
    12961 tgaggatatc attgcgatcg gaaagcgtct cgctgaggaa tacggtgatc gtttcgttaa
    13021 cgaagaggaa agtgaacgcc tcgcgttttt ccgtgaatac ggcctgaaat acgagctgga
    13081 aaagcttcgc aaggacttgg aaaacttccg tgtgccgttt gatgtgtggt attcagaaac
    13141 ttcactgtac caaaatggaa aaatcgacaa ggcgcttgaa gcgctccgcg aaaaaggcca
    13201 cgtctatgaa gaagacggcg cgacttggtt ccgttccacg actttcggcg atgataaaga
    13261 ccgcgtattg atcaagaagg acggcacgta cacgtacctt cttcctgata tcgcgtatca
    13321 taaggacaag cttgaccgcg gctttgataa gctgatcaac gtttggggcg ccgatcacca
    13381 cggctacatc ccgcgtatga aagcggcaat cgaagcgctg ggctatgaaa aaggaacgct
    13441 tgaagtagaa atcattcagc tcgttcacct ttacaaaaac ggcgagaaaa tgaaaatgag
    13501 caaacggacc ggtaaagccg taacgatgcg tgacctgatt gaagaagtcg gcttggatgc
    13561 cgtgcgttac ttctttgcaa tgcgaagtgc agacacccat atggattttg acttagatct
    13621 tgctgtatca acatctaacg aaaaccctgt gtattatgca caatacgcgc atgcccgtat
    13681 ttgcagcatg cttcgccaag gggaagagca ggggcttaaa ccggcggcag atcttgattt
    13741 cagccatatt caatcagaaa aagaatacga tctgctgaaa acgatcggcg gcttcccaga
    13801 ggcagtggcg gaagcagcgg aaaaacgaat tccgcaccgt gtcactaact atatttatga
    13861 tctggcttct gctctgcaca gcttctacaa cgcagagaaa gtcatcgacc ctgaaaatga
    13921 agagaaaagc cgcgcgcgcc tggctttaat gaaggcaacg caaattacgc tgaacaatgc
    13981 gcttcagctg atcggcgtat cggctccgga aaaaatgtaa tcacgatcaa aaggacaaag
    14041 tcttcgggct ttgtcctttt tttatgagaa aaacgtgtga tgtaattcac aatcctgttt
    14101 ggctagtttt tgtatgataa gactgattat tgaatcattg aaaggggcaa gccaaatgat
    14161 caaccgtcaa cacattcaat tatcgttaca gtcattaagc ttggtggcag ggtttatggt
    14221 ttgggtgctg atttcatcac tcatttccca aatcacatta gatattcatt taagcaaggg
    14281 tgagatttct ttagtgaccg cgattcctgt gatcctcggg tcgcttctcc gcattccttt
    14341 agggtattta acgaacaggt ttggcgcgcg gctcatgttt atggtcagct tcatcctgct
    14401 tttatttcct gtattttgga tcagtatcgc ggattctctg tttgatttaa tcgcaggcgg
    14461 ctttttctta gggatcgggg gagcggtgtt ttccattggg gtgacctccc tcccgaaata
    14521 ttatccgaaa gaaaagcacg gtgtcgtcaa tgggatttac ggtgcaggaa atatcgggac
    14581 agccgttacg acatttgcag cgccggttat cgctcaagcc gtcgggtgga aatcaaccgt
    14641 gcaaatgtat ctgattttgc tggctgtctt tgccttactg cacgtattgt ttggcgacag
    14701 gcatgagaag aaggtcaaag tttctgttaa gactcaaatc aaagctgttt accgaaatca
    14761 tgtgctatgg tttctgagcc tgttttattt tattacgttc ggtgcctttg tcgccttcac
    14821 tatctatctg ccgaactttc tggtggagca ttttgggctg aatcctgcag atgccggctt
    14881 gcggacggct ggctttattg cggtttctac gctgctcagg cctgcgggcg gattcctggc
    14941 tgataaaatg agcccgctcc gcatcttgat gtttgttttt gccgggctta cattatcagg
    15001 cattatccta tcgttctcgc cgacaatcgg cctttatacg tttggatcat taaccgtggc
    15061 cgtctgctca ggcataggaa acggaactgt ttttaaactg gtgcctttct atttttcgaa
    15121 gcaagcgggg attgccaatg ggattgtgtc tgccatgggc ggtttaggcg gcttttttcc
    15181 tccgctcata ttggcgagtg tatttcaggc aacaggccag tacgcgatcg ggtttatggc
    15241 gctttcagag gtggcgttag ccagttttgt ccttgtcata tggatgtatt ggcaggaaag
    15301 aatgaaaaca cacacggaga gaaacagcca gagcatcaac taacactggg gcattcacaa
    15361 gattgttagt tttttctcga tgggtacaaa tcaattcacg ttacaataaa cacacaacgt
    15421 gactttcttc gaggtgagct catgaatttt ctctctgttc gaccatctga tagtgatctt
    15481 atatccagcg atctgcatga actgctggaa tcgatcagca cgaaaagaaa aatggaaaaa
    15541 cacacgtatt tgtttcggga aggaatggat gcagaagagc tttatctgat tcaatcagga
    15601 ctcattgaaa tcggcaagct gacatctgac ggaaaagacc tgacgcttag aatctgccaa
    15661 aagcatgata tcgtcggaga attaacactt ttcactgaag aaccaaggta tatgctcagt
    15721 gcaaaagtac tagaggatgg cgaggtgctc gtcattaata aaaataagct ggaaaaagaa
    15781 ttaatccaaa acggcgcttt gacatttgag ttcatgaaat ggatgagcac gcacctccgg
    15841 aagattcagt ccaaaatcag ggatctgctt cttcatggca aaaagggggc gctctattct
    15901 acccttatcc gcttatcaaa cagctacgga gtggagcgaa gcgacggcat tctgattaac
    15961 attgtcctga caaatcagga tttggcaaag ttttgcgcgg ctgcacggga aagcgtcaat
    16021 cgtatgctcg gagatctccg caaaaaaggg gttatttcga tagacgaatc cggaaaaatt
    16081 attttgcaca agcgggacta tttacgatgt gagattgagt gtgaaaattg cccgctggag
    16141 atttgcaata ttgactgaaa aaaacaagga cagcggtgtc cttgtttttt taccttgtga
    16201 taaacaggca catgacggca agaaagaagc aggcattcac gatttcaaga atgccaatcg
    16261 tttttacggg ccaatccctt ccatgaaaaa accatgcccg caagctgctc gggataaaag
    16321 cgagaaacgc ccatcctgct ccgaaaagag cggataaaaa ggggagcagc aggtgatatc
    16381 cccatgacca gtatgcaaat gccctgtttt ttctctcgcg gatcaccgat ttcacataaa
    16441 aggaactccc gataaaaaat aaagcagact gcaagaaaat aaaccaagcc cagccgtcaa
    16501 gggttcccat ccccagccag cagctcgcaa acccgcccga acaaaagaac aagacacctg
    16561 caacatcatt caataaggct cgttcgtttt ttctgcgggc aaaatacata tgtatgagaa
    16621 acagcggcag taaagaaacg cccacccaga tgagaggcgg cttatgaaag accgagatca
    16681 tcaaaaagca gcaggcggga aaaccgtaat aacacatcca cttttgatat ggtttgcttt
    16741 gtttcttttt taaggcaagc gtaacgggat aaaccgctaa gtataggaaa agccaaccaa
    16801 ggaagagcgg aatatgccaa ataacggggc ctcccttgac catgccgagt aaaaatggga
    16861 tcagcagcat cgcccacgcc ccgtgctgct tcggaatcag cgccttcatc gaaatcctcc
    16921 ttttttcttt cattataaat gcattcaccc tcctgataag tgacattcat catacaggct
    16981 gtgaaataca tcactgctgt acaggctcag tcgagctaca ctaaagctat ccttagcaca
    17041 ggaggttttc ctatgaatca gtgtgactat ttattatttc tgaaacaact tcctatgttt
    17101 aatgaagtgc ctctatccat tgtcgaaacc ttgctgaaaa acggcacgtt tatccgcggt
    17161 tcatgtgatc agtctccatc ttttcttcat tctcaatctg tttatattgt attaaaaggc
    17221 agtgtccgtt ttatggacac aaggctccct gaagggtcga aaaccgttgc gctgtgggaa
    17281 aaaggcgatg tgtttccgat tgatgaaaaa ggcgggcttt atttatcgcc ctttatctca
    17341 gtcaatgcca cttcagacat tctgattctc aacatcccat attacatatt taagaaaatg
    17401 atgtcttatc atccgcagct gcaaatgaac tttttggcta tgcttcagca aaatgttttt
    17461 tgttcctatc aattattttt gcggtatctg catacatcac aggatgaaaa cgccgagccc
    17521 ggttcttaaa tagagccggt tttttttgat ctttgaatga aaggcagcta atgacccaag
    17581 cgtcctgcct gaactcagcc ttccttctcc tttgtgtgaa cattttgtga aaaaagcaga
    17641 gtgtgtgaca tagttcacaa ggaaacacgc tgtctctgtt tatagtgaaa ttagcatcac
    17701 ctgactcgga aggagtgaac tctcatgaag aaaaagaaaa ggagtccgtt gtttaggaga
    17761 ttgaattatt tctctcctat cgaacaccat tcaaataaac atagccaaac cacccgcgaa
    17821 gatcgcgatt gggagaatgt atacagaaac agatggcagt acgacaaagt cgttcgctcc
    17881 acccacggcg ttaactgtac agggtcttgc agctggaata tttatgtgaa aaacggaatt
    17941 gtcacgtggg aagggcaaaa tttgaattat ccttcaacag gcccggatat gcctgatttt
    18001 gaaccgagag gctgcccgcg gggggccagt ttttcatggt atatctacag cccgctgcgt
    18061 gtgaaatatc catacgtgcg cggtgtactg attaatttat ggcgggaggc actgcaagaa
    18121 catcaaaatc cattggaagc ctggaaatcg atcgtcgaaa accctgaaaa agcgaagtcc
    18181 tataaacagg cgagagggaa aggcggtttt gtgcgcgctg aatggccgga ggtgctgaag
    18241 ctgatttcag cctctctgct gtatacagtg atgaaatacg ggcctgacag aaacgtcggt
    18301 ttttctccga ttccggccat gtccatgatc agccatgcat caggctcccg gtttatgtcg
    18361 ttaatcggag gccctatgct cagtttttat gactggtatg cggatcttcc tccggcatcc
    18421 ccgcaaattt ggggtgacca gacggacgtt ccggaaagca gtgattggta caattccggc
    18481 tatatcatca catggggctc caacgttccg ttaacgagaa cgcctgacgc gcattttttg
    18541 gcggaggccc gctataaagg cgctaaggtc atttcgatca gtccggattt tgcggaatcc
    18601 tcaaagttcg cggatgactg gctgagtatt cgccaaggga ctgacggggc gcttgcgatg
    18661 gcgatgggtc acgtcattct gcaggaattt tacgtgaacc aagaaactga acgttttatt
    18721 gagtacgcga agcaatacac tgattttcca tttctcgtca ccctgtcaaa agaaaatggc
    18781 gtatacacag cgggacggtt tctgcatgcg aaggacatcg ggcggaagac aaagcatgat
    18841 cagtggaagc ctgcggtttg ggatgaacag acaagttcat ttgccatacc ccaagggaca
    18901 atgggctcgc gctgggacgg gcagcagaaa tggaacctgc acatgattga tgaagaaacc
    18961 ggggaaccga ttgaaccccg tctctctgtg ctgggaatag aggacgaaat cggcacggtg
    19021 cgcatcccgt atttttcaaa tgacggaaac aaagtgctcg agcgggatct tcctattaaa
    19081 aaaatgaacc tgaacggtga agaaacgtac atcacgaccg tgtttgactt gatactggct
    19141 aactacggcg tgaaccgggg tatcggcgaa cgatcggctg tctcctatga tgatcctgag
    19201 ccgtttacgc ctgcctggca ggaacaaatg acaggaatca aaaaagaagc tgtcgttaag
    19261 attgccagag agtttgccca aaatgcgatc gatacagacg gccggtccat gattatcgta
    19321 ggggccggca ttaaccactg gttcaactcc gacacgatct accgagcggt gttaaatctt
    19381 gttttacttg taggcgccca aggcgtaaac ggcggaggct gggcccatta cgtggggcag
    19441 gaaaagctcc gacctgctga agggtggcag acgattgcaa ctgcaaagga ctgggaaggc
    19501 gtgcccaagc tgcaaaatgg cacctcattt ttctactttg cgacagatca gtggcgttat
    19561 gaggaccagc cgatcagtga tttggcatca ccgattgctg cttcatcccg ctacaagcac
    19621 cacgctgatt acaatgtgct ggcggcgcgg ctggggtggc ttccgtctta cccgactttc
    19681 aatcaaaatg gcatcgatct gtataaagaa gctgaaaaag caggggcagc aacacctgaa
    19741 gacgttggtg cgtacgtggc ctcacagctc caagagaaaa aactgaaatt cgcgattgaa
    19801 gatcctgaca atgaagtgaa tttcccaagg aatctctttg tatggcgggc aaatctgatc
    19861 tcaagctcag gaaaagggca tgaatatttt ctcaagcatt tgctggggac aacgaacggt
    19921 ttaatgaatg acgacagcga cagcatccgc ccagaagaaa tcaaatggcg ggagcaggcg
    19981 ccggaaggaa agctcgactt attaatcaat cttgattttc gaatggcggg tacggcgctg
    20041 tattccgata tcgtgctgcc ggcggcgaca tggtatgaaa aacacgatct cagcagcaca
    20101 gatatgcatc cgttcattca tccatttgct ccggcgatct cagctccgtg ggaatcgaag
    20161 tcagactggg atattttcaa ggcgctgtca aaagccgttt ccgatctggc agaagaagtc
    20221 aatatggagc cggtgaaaga agtggttgcg acgccgctcc tccacgacac catgcaggaa
    20281 ttggcccagc cattcggcaa aatcaatgac tggagcaagg gcgaatgtga agccattccg
    20341 ggaaaaacga tgccgaacat ccaagtcgtt gaacgggatt acaaacacat ttttcataaa
    20401 atgaccgcac tcggtcctaa cgctgcttta aagccgagcg gaacaaaagg gatgagctgg
    20461 tcaatagccg atgaatatga atcactcaaa cagagactgg gagaaatcac ctcagacagc
    20521 gtggcaaagg gatgtccaaa tataagtgaa gcaaagcagg cggcagaagc ggttttaacc
    20581 ctatcatcca cttcgaatgg aaaggtcgcc gtaaaagcat gggaatcact tgaaaacatc
    20641 acaaacctga agctgaaaga cctggcggaa gagcgcgagg aagaatgctt tacgttcgaa
    20701 caaattacag cccagccgaa aacggttatc acgtctccgg catttaccgg ctctgaaaaa
    20761 ggaggccgca ggtattcgcc gtttacaacg aatgttgaaa aattaatccc gtggcggacg
    20821 ctgacaggca gacaaaccta ttatgtcgat catgaactga tgatggaatt cggtgaaacg
    20881 atggcgacat tcaaaccgat cctccagcat cgcccgtttc tgagcaagcg gcctgatcaa
    20941 gagggaaaag aaatcgtcct caattatttg acgccgcata ataaatggtc tgtccacagc
    21001 atgtattttg attctctgcc gatgctgacg ctgttccgcg gcgggccgac cgtgtggatg
    21061 aataaagatg atgcagagga cacggatatc aaagacaacg attggattga atgcttcaac
    21121 cgaaacggtg ttgtcgtcgc aagagcggtt ttgtctcatc ggattcctaa aggaatggcg
    21181 tttatgcacc atgcccagga ccgccacatc aacgtgccag gcacaaagct gacgaataac
    21241 cgcggaggca cccataacag cccgacaagg attcacgtca agccgacaca gatgatcggt
    21301 ggctacgccc agctcagcta cggctttaat tattacggtc caacggggaa tcagcgcgac
    21361 ctgaacgtcg tcatccgcaa gctgaaggag gtcgattggc ttgaagatta aagcgcaaat
    21421 cggtatggtc atgaacttgg ataaatgcat cggctgccac acgtgcagcg tcacctgcaa
    21481 aaacacgtgg acaaaccgtt ccggtgcgga atatatgtac ttcaataatg tagaaacaaa
    21541 gccgggcatc ggctacccga agcaatggga ggaacaggac aaatataaag gcggctggac
    21601 attgaaaaaa gg
//
