LOCUS       NZ_CP046591            24458 bp    DNA     circular CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain R31 chromosome, complete genome.
ACCESSION   NZ_CP046591
VERSION     NZ_CP046591.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4186822)
  AUTHORS   Yu,G.
  TITLE     Study on the banana fusarium wilt control by endophytic Bacillus
            subtilis strain R31 by regulating banana rhizosphere microbial
            community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4186822)
  AUTHORS   Yu,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2019) Institute of Plant Health, Zhongkai
            University of Agriculture and Engineering, Dongsha, Guangzhou,
            Guangdong 510000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 450.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015602625.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:59:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,377
            CDSs (total)                      :: 4,256
            Genes (coding)                    :: 4,150
            CDSs (with protein)               :: 4,150
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 67 of 106
            Pseudo Genes (incomplete)         :: 47 of 106
            Pseudo Genes (internal stop)      :: 16 of 106
            Pseudo Genes (multiple problems)  :: 19 of 106
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:59:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2455635
            Orig. end                         :: 2480093
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP046591.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24458
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="7"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24458
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24458
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14458](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14458)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(135..151)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.42"
                     /tool="antismash"
     misc_feature    complement(911..925)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(1081..1096)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.19"
                     /tool="antismash"
     misc_feature    complement(1362..1375)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     misc_feature    complement(1381..1395)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.38"
                     /tool="antismash"
     gene            complement(1456..2640)
                     /gene="ybdO"
                     /locus_tag="GO004_RS12780"
                     /old_locus_tag="GO004_12770"
     CDS             complement(1456..2640)
                     /codon_start=1
                     /gene="ybdO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388087.1"
                     /locus_tag="GO004_RS12780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12770"
                     /product="DUF4885 domain-containing protein"
                     /protein_id="WP_195727664.1"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLMAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKTSVSGNSGAFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEAYQKYQ
                     AAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMEVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLIDVGQSKSYGTGDTGWLEALKRQTGVNY"
     misc_feature    complement(2706..2715)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            2772..3629
                     /locus_tag="GO004_RS12785"
                     /old_locus_tag="GO004_12775"
     CDS             2772..3629
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388086.1"
                     /locus_tag="GO004_RS12785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12775"
                     /product="hypothetical protein"
                     /protein_id="WP_015715159.1"
                     /transl_table=11
                     /translation="MVKKWLIPFAVMLSVLFTFTYSASAAGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYVRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     VAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTS
                     ENNEWRRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     gene            3715..4485
                     /gene="pkrD"
                     /locus_tag="GO004_RS12790"
                     /old_locus_tag="GO004_12780"
     CDS             3715..4485
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pkrD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388085.1"
                     /locus_tag="GO004_RS12790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12780"
                     /product="protein kinase"
                     /protein_id="WP_015715158.1"
                     /sec_met_domain="Pkinase (E-value: 4.6e-32, bitscore:
                     109.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDI
                     LTQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLNSIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIDEEYQHTASIREDLNRAIQSIT"
     gene            complement(4470..4721)
                     /locus_tag="GO004_RS12795"
                     /old_locus_tag="GO004_12785"
     CDS             complement(4470..4721)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097672.1"
                     /locus_tag="GO004_RS12795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12785"
                     /product="hypothetical protein"
                     /protein_id="WP_133516498.1"
                     /transl_table=11
                     /translation="MCLKKSSKRLSTSQAVLVTDIADTGITAAGADIIAATAAARAKED
                     TTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVID"
     gene            complement(4787..5773)
                     /gene="ybdK"
                     /locus_tag="GO004_RS12800"
                     /old_locus_tag="GO004_12790"
     CDS             complement(4787..5773)
                     /codon_start=1
                     /gene="ybdK"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234894.1"
                     /locus_tag="GO004_RS12800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12790"
                     /product="two-component system sensor histidine kinase
                     YbdK"
                     /protein_id="WP_195727665.1"
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLHLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKPADQDVIWMSNALWMERLFDNIFQNTLRHSKAEKMEVTIEHGDVFIR
                     DDGIGFDRNESSEGLGLKIIDDTCRLLAITYELHTNDNGTGFLFSKE"
     gene            complement(5770..6441)
                     /gene="ybdJ"
                     /locus_tag="GO004_RS12805"
                     /old_locus_tag="GO004_12795"
     CDS             complement(5770..6441)
                     /codon_start=1
                     /gene="ybdJ"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388082.1"
                     /locus_tag="GO004_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12795"
                     /product="two-component system response regulator YbdJ"
                     /protein_id="WP_015382624.1"
                     /transl_table=11
                     /translation="MKGYHILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKELGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     gene            complement(6443..7420)
                     /gene="ybdG"
                     /locus_tag="GO004_RS12810"
                     /old_locus_tag="GO004_12800"
     CDS             complement(6443..7420)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybdG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388081.2"
                     /locus_tag="GO004_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12800"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_046664310.1"
                     /sec_met_domain="PF00561 (E-value: 5.7e-07, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVCVSVFIYHHFQLNKEAALLKEKG
                     TVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFMPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYEVFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR"
     gene            complement(7623..9380)
                     /locus_tag="GO004_RS12815"
                     /old_locus_tag="GO004_12805"
     CDS             complement(7623..9380)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="GO004_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12805"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015715153.1"
                     /transl_table=11
                     /translation="MGNNHLLLLLKLVKWPKKILVYILFSLLFTTILSLVIPILTKNTV
                     DQFTDGTVNWALTIMLAGLFLINILLSGLSFYYLAFLGENATYYIRDKMFSHILDLPLT
                     FFDKNESGQIVSRVIDDVELMNTFISDKIPNFASQLIVVAGSLILLFVLDWKITLLMLI
                     SVPISLAVMIPLGNKMYKISLEKQNNMAIFTARISSAFSGIRLTKSYTAEKEEYGKGNV
                     ILKRIFKLNLKDTKIQAYMMPIMSTVILMIILLLVGYGGIRLSEGTISPGTFVAIIFYL
                     VQFVTPLSSLSNFFTEYKKTLGATKRLYEIYSLKPEAENKQISSNAFNLGNGDLKFENI
                     SFQYNDPSSEVFNKLNLRFPKNKITAVVGPSGAGKSTLFNLIERLYEAQNGEIYYESTP
                     IKDIDLTVWRKKIGYVMQDTLMITGTIKENLTYGLSGSVSQETIIKYSKLANAHDFIME
                     LPDNYETFIGERGIKLSGGQKQRIAIARALIKNPEILLLDEATSNLDSESEILVQQSIN
                     RLVRDRTTIIIAHRLSTIRDADNIVFLENGVVTGSGNHLDLINNHEKYREFVNGQLLNN
                     TSISASSLS"
     gene            complement(9398..9988)
                     /locus_tag="GO004_RS12820"
                     /old_locus_tag="GO004_12810"
     CDS             complement(9398..9988)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039548.3"
                     /locus_tag="GO004_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12810"
                     /product="DUF5823 family protein"
                     /protein_id="WP_015715152.1"
                     /transl_table=11
                     /translation="MIQAVLEITIKFLTELISFELPVYMYIWFAVLFIFSMIVENVQLA
                     IAKDSILNSILKRLGIKILSLLVVLIIGVLGSNFFAQVVEDAVNKESNLAYYILSTTIA
                     TALTIIEPIIETMKKFIKEQSNLAFANFTVSVICLTVTFQAVSSIFSDYFILATPYKVV
                     LIISSAIGIVYLVKFDQNNLEVNSESVHSNKND"
     gene            complement(10001..11323)
                     /locus_tag="GO004_RS12825"
                     /old_locus_tag="GO004_12815"
     CDS             complement(10001..11323)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="GO004_RS12825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12815"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_163260154.1"
                     /sec_met_domain="LANC_like (E-value: 2.6e-61, bitscore:
                     205.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKCKNPDFLTDILLDIANSIKDKSETEKIILGDQNNPEDIIEVV
                     SLAAGYPGICVFLGYMDKVFPEDGWDVVAHDYLTDLISLIQTNKTYSLSLFNGLAGVLV
                     ALETCSRGGTRYTTIINQVLTLILENYKHYLSEDLLKLKKEGVSASEYDVISGWTGVGR
                     TLLHFDQISNKGDISLKKALHDIAEYLLLVSSIDTLSNMPNWLISNENLPLDIEKKTYK
                     KGYFNSGMAHGISGVLAFLSILKKENYKIKNLELGIKNIQNWIFEKVKTHKGIYYIPNV
                     IENEVVRNEAFFNHRDAWCYGTPGVSRAIFLSGIALNDQRVKMKALELFKTFFLRDEKD
                     RKIISPTICHGYAGILMLTLRMYKDTNDRFLADKMHDILNEMLTFYSQLNFSKFNNYEL
                     ISGKIVEEKKVGLLEGSTGIALVLISFIFGQDSWDKIFLIS"
     gene            complement(11348..14458)
                     /locus_tag="GO004_RS12830"
                     /old_locus_tag="GO004_12820"
     CDS             complement(11348..14458)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="GO004_RS12830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12820"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_015715150.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-131, bitscore:
                     438.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.7e-07,
                     bitscore: 29.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.2e-31, bitscore:
                     106.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKYLSSDLFMYRKPILDLSFYKECLAFDNEFNEEEYIAKISNL
                     LNTNPTIAEAIYFASEPLYNSFLNIEKLKKKKRKSVIDSMLKFLIRMSTRPTPFGLFSG
                     IGVETFSGQDEYLTKDSEVIKNTRLDMCWIYFLIRKLESNLSILEQLTVENNSLVYNHG
                     DRIKLSYQSLLHSDDNDQSLEMLTLRKTAVMDYVYSQAEFGINYSTLRDSINKTYSVTD
                     DISNDFLNSLLKNEVIITNLRTSLVNSDPFENILNIISKMHNVEEELNYLVRLKKSIEE
                     YKKSSGELGISILKKIKKEMRVIGYEGDDFLRTDLYYVRNKKRYINNNQKDSIEKLAEI
                     LSLLGSVNSFQPLEAYRDEFIDKYGIFQEVPLLELIDEELGIGLPPEYHENRHKPSQPE
                     PSNEFHRIKNIISSWQAEVSLSKNHEIKLDDEKIKHLFNSEELNNIAVSQELELYFNIL
                     LDEHKENKLYLNPNCGSNSLFQTYGRFKYFLGESDKEYIKQFSHIEKDVIFAEVTYYPT
                     HGKTANIINAETCFDYEIAFSCNSSKDNKHSIALSDLYVGSTYNFIYLKSKKLDKIIIP
                     KLSHMFNYSMGPKVYRFLVDIGVQYQKQWSNIDSFFYDAPIKPRVIYNNIVLSPKKWNL
                     NKSIIPFECDSGEKFHYYIKDWKKRYKVPDFIYLIEFDNKLLLNLENISHIKIIYNEFK
                     KLSNNQSLHFLEAEKELFNNHNNEIEEYVFTLKSKLHQLELDSYMTNIQSEMPFKYIGD
                     NERLKFLGTEWIYVKLYGLGTRENEFIADELGSFIKKHLDKGTIKSSFFIRYSDPKQHL
                     RVRFKVEKNNIFDTVLPIIIKWLEEMRTKGFVNYYCFDPYNPEIERYGGEQSYKIAEDL
                     FFCDSLIVSEWIQINRSGNVNIDEVTFGVFNILQLLKLFNLNIEEQMTWLEINTKPQKY
                     ANKFRGKKSTLIELADLIYTNKKLDKYNKISSIIEIREKTAITYSKSIENNPDFLIKNI
                     IMSVIHMHCNRLYGINRDKENLVIGLAYHTIKNYNNALKYNNVLIPN"
     aSDomain        complement(13727..14002)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GO004_RS12830_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.10E-09"
                     /identifier="RREFam001.1"
                     /label="GO004_RS12830"
                     /locus_tag="GO004_RS12830"
                     /protein_end="244"
                     /protein_start="152"
                     /score="29.8"
                     /tool="antismash"
                     /translation="VENNSLVYNHGDRIKLSYQSLLHSDDNDQSLEMLTLRKTAVMDYV
                     YSQAEFGINYSTLRDSINKTYSVTDDISNDFLNSLLKNEVIITNLRT"
     gene            complement(14459..15427)
                     /locus_tag="GO004_RS12835"
                     /old_locus_tag="GO004_12825"
     CDS             complement(14459..15427)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="GO004_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12825"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_164906779.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.8e-25, bitscore:
                     87.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTNALPNQFSWNSYKVTNGYRLYDLQVGSPLIKIAVIDSGYDPN
                     HSEITGNIDKKKSCSFVDYENFNEDLYGHGTAVISVIVGKNQVKGVAPGITIISYKVLD
                     RNGFGKIEWVIHAILKAIEDCVHIINLSHVFTMFGLGNKGAFNKLQQAIDKARKKGIII
                     VGAAGNQGVLLDMKSTSLYPTIKGINYVTSTNKNNYTSSYANIGSIIRFAAPSGELDET
                     NNVTDLIIVAHPTNFPKTKFEKAIGLPDFYTVTCGTSISAAMFSSLIALVLTEYLICKQ
                     IHLSEKEILNIIQKNSSRVKDQNSIFEINAYSVIKFIKGLL"
     gene            complement(15521..15691)
                     /locus_tag="GO004_RS12840"
                     /old_locus_tag="GO004_12830"
     CDS             complement(15521..15691)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Antimicr18"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001031158.1"
                     /locus_tag="GO004_RS12840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12830"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_015715148.1"
                     /sec_met_domain="Antimicr18 (E-value: 8.4e-06, bitscore:
                     23.8, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNNIFDLDINKKMESTSEVSAQTWATIGKTIVQSVKKCRTFTC
                     GCSLGSCSNCN"
     CDS_motif       complement(15620..15691)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKNNIFDLDINKKMESTSEVSAQ"
                     /locus_tag="GO004_RS12840_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15521..15619)
                     /prepeptide="core"
                     /locus_tag="GO004_RS12840_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.10"
                     /molecular_weight="3235.8"
                     /monoisotopic_mass="3233.6"
                     /core_sequence="TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKNNIFDLDINKKMESTSEVSAQ"
                     /leader_location="[15619:15691](-)"
                     /alternative_weights="3253.8"
                     /alternative_weights="3271.8"
                     /alternative_weights="3289.8"
                     /alternative_weights="3307.8"
     gene            complement(16010..>16357)
                     /locus_tag="GO004_RS12845"
                     /old_locus_tag="GO004_12835"
                     /pseudo=""
     CDS             complement(16010..>16357)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388059.1"
                     /locus_tag="GO004_RS12845"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="GO004_12835"
                     /product="glutamine--fructose-6-phosphate aminotransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VCVEGALKLNEIS"
     gene            complement(16456..17628)
                     /gene="ybcL"
                     /locus_tag="GO004_RS12850"
                     /old_locus_tag="GO004_12840"
     CDS             complement(16456..17628)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybcL"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388070.1"
                     /locus_tag="GO004_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12840"
                     /product="MFS transporter"
                     /protein_id="WP_195727666.1"
                     /transl_table=11
                     /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQL
                     ITIFSLVYALSTPVLMALTASMDRRKLMMYALGLFVFGNVLAFVLPGYGWFIAARIIMA
                     MGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIAVALGWKSVFG
                     AIALLGLIAMVVIFFTLPHTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYSVAYT
                     YLSPYLLNISGINGKLLSGVLLIFGIASLVGSKFGGYSTDKWGVPFTLVGGMTLHIVTL
                     ILLSLVTHSYIGVLMILILWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSMMQFAMA
                     VGAGIGGVFVENVSLASITWVGALGIMIAIITSLRIFHSQPKQTLKDINQ"
     gene            complement(17755..18057)
                     /gene="ybzH"
                     /locus_tag="GO004_RS12855"
                     /old_locus_tag="GO004_12845"
     CDS             complement(17755..18057)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="ybzH"
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097670.1"
                     /locus_tag="GO004_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12845"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_015715145.1"
                     /transl_table=11
                     /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFAPHEGIDMNTIGVCVS
                     QITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIEKLADFLKTEI"
     gene            complement(18502..18864)
                     /gene="ybcI"
                     /locus_tag="GO004_RS12860"
                     /old_locus_tag="GO004_12850"
     CDS             complement(18502..18864)
                     /codon_start=1
                     /gene="ybcI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019257313.1"
                     /locus_tag="GO004_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12850"
                     /product="DUF2294 domain-containing protein"
                     /protein_id="WP_015715144.1"
                     /transl_table=11
                     /translation="MKKSKGSIESEISKSITQWEKDYLGRGSVSVKTDILRDMIIVNLK
                     GILTPAEYVVCGSKEGMLSIKQTRSELVESGIEGLKDIILKITGEKVKSFHTDLSSRTG
                     ERVMVFKLCNDLEKNL"
     gene            complement(18922..19212)
                     /gene="ybcH"
                     /locus_tag="GO004_RS12865"
                     /old_locus_tag="GO004_12855"
     CDS             complement(18922..19212)
                     /codon_start=1
                     /gene="ybcH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388068.1"
                     /locus_tag="GO004_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12855"
                     /product="DUF6407 family protein"
                     /protein_id="WP_015252954.1"
                     /transl_table=11
                     /translation="MSANLTDFVTKTIEDMNSFDRENMECMKKLIRKAIDFYHLKSYEE
                     VEETHSGNVRFLHVHSMMEENMLSKMIVVTRNGKTDLDIEGVYEGYVVREY"
     gene            complement(19276..19803)
                     /gene="ybcF"
                     /locus_tag="GO004_RS12870"
                     /old_locus_tag="GO004_12860"
     CDS             complement(19276..19803)
                     /codon_start=1
                     /gene="ybcF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388067.1"
                     /locus_tag="GO004_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12860"
                     /product="carbonic anhydrase"
                     /protein_id="WP_046664311.1"
                     /transl_table=11
                     /translation="MNVNQNKKVLFLTDIENGLEPILQEATNTSAENMLTIQSYGAGIS
                     HPYGEIMRSVIFAIYQEDVEEIFVVGTKDKKTSAGNGLTQLETMKDKIQTLDYLFQNCK
                     PEFLGGTVDEWLNENSSDTIEKSVDMIRHHPLVPSYVKVRGLFVHHKDGKPSIVEVPDV
                     KTGQALPDHCLL"
     gene            complement(19880..22495)
                     /gene="mpsB"
                     /locus_tag="GO004_RS12875"
                     /old_locus_tag="GO004_12865"
     CDS             complement(19880..22495)
                     /codon_start=1
                     /gene="mpsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388065.2"
                     /locus_tag="GO004_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12865"
                     /product="YbcC family protein"
                     /protein_id="WP_195727667.1"
                     /transl_table=11
                     /translation="MGITSVLTKDNVKKIDTDIDVQERDLNVFITSASRVIAPLWPIST
                     FAARNPWMGLENQPFDQVASWLKNTRDVDIYPSASMIRSAKNKGEIDEDFVEMGLQRWL
                     DSHSYHIPRDVAERFCHAALKLDPLPSDLLSSHKLEKLVSECDGLDHIENVFMQPLSSY
                     IENQDGERLVNILDHHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPALSKKQ
                     RERVKGWPKEAHLALQKALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQSSHEHA
                     LLTEYLAVRISMEWALIKPYLPLTNERSKKTISIAPLIAAWIHWGGLTLEEWSQMTAIE
                     QNEYLSFAYSFDEKLRKKLWLEAWEQTYTDRLSQKIISKQRETGRKKSALAQLAFCIDV
                     RSEPFRRHLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQNKIKEFADED
                     VFKKYNQRKQAIHSLSHTFKTMKQNALSSLLLPELSGPWLTLQMAARSFVPRKAGRFIR
                     NLREAWLRKADTKLSLHHDTTEAEIPVGFTDEEKVNYARQALKMMGLTENIAPLVVICG
                     HGSQSTNNPYSAALDCGACGGAAGGFNARVLAALCNLSEVREALLAEGIQIPEDTVFAA
                     AEHNTTVDELHWLYVPELSEAAQEAFEQIEAVMPKVRHHVNAERLAQLPNFQSKLKNPK
                     AEANRFAEDWSEIRPEWGLARNAAFIIGKRELTQDCDLEGRAFLHNYDWKQDESGELLA
                     NIIAGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTAGLGVMQGNASDLLAGLPWQS
                     VMESDHEAYHSPLRLLILIQAPREYVERLLNNDSAFLQKVQNGWVRLASLDPEGCWESW
                     "
     gene            complement(22510..24027)
                     /gene="mpsA"
                     /locus_tag="GO004_RS12880"
                     /old_locus_tag="GO004_12870"
     CDS             complement(22510..24027)
                     /EC_number="1.6.5.9"
                     /codon_start=1
                     /gene="mpsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388064.1"
                     /locus_tag="GO004_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GO004_12870"
                     /product="NADH dehydrogenase subunit 5"
                     /protein_id="WP_015252958.1"
                     /transl_table=11
                     /translation="MLVSLSLSSLLTLFFIMLMASGISGLLFLHPRVPLSFVRIHIGIL
                     ALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSYRK
                     YFALFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKISGRLF
                     LLSWFSLFFAMMWLFHATGQWQLSLVVTNESIAGLGEWERTGIQLLIVLAVIIPAGQWP
                     FQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLAGISVLIGT
                     GISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQAGSAVG
                     RHEVSARTNERTSYLWVMAGRILSLVIGVAFWLTAPGDGYHLISALILGWSLSVSWTQL
                     VAFGEGRIGRIAGLTVLGGAALVYFIIHHLFYKWLHTTIFQSVQPPMSAVMIVVCLLLF
                     GSALGTWVARHRSSVFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS"
ORIGIN
        1 ttctgaatcc gatatggctg atcaaaatga taaaccaagg aatcatccct gggagcacgc
       61 ttgcgctgta tacatagaca aagatcttcg gcggcgcgat atagttcagt acaacgccga
      121 cagccaaacc gatcagcacc gcaattgtgc catacagcgg cacaccattg cgtgaaatct
      181 tcttaaagaa tttcggtgct tgtccattga cacccagtgt atacagcatg cggcccgcgc
      241 tgaaaatacc gctgttacag ccggacattg ccgcagtaat cacgacaaag ttaataatgc
      301 cggccgctgc cgtaatcccg attttcgaga acgtagacac aaacggactt ccgagtgagt
      361 tgagctcatc ccaaggatac accgtcacga tcacaaaaat agcgccaatg tagaaaatca
      421 aaatacgcca gataatactt tgaatcgcat ttcttagcgt gttttgcgga tcctttgctt
      481 cacccgctgt aatcccgatc agctcaactc cttgataggc cgcaatgaca agagacagtg
      541 caaagaagaa acctgagaaa cctcctgcaa agaagccccc gtgagaccac aggttcgaca
      601 aaccgatcgc atctccgcca ttgccaaaac cgaagaaaat aattccgatt cccgcaataa
      661 tcatcaagat aatcgtcacg attttaatca tcgcaaacca aaactcaaat tcgccaaacg
      721 acttaacaga aattaaattc gccgcaccaa gaatcaccat tgccacgata ccaggtatcc
      781 aagcaggcaa atccgggaac caatacttca tataagaacc gacagcgata atttctgaca
      841 tgccgacgat aatccactgg aaccagttgc tccatgctgt tatataacct gccatcggat
      901 gaatatattg atggccgaac gtcgcaaaag aacctgtgct cggctcgaca tacagcattt
      961 cacccatcgc acgcataata aaaaagataa aaattccgca tattgcataa gccagaagga
     1021 cagatgggcc agtccatgaa atcgtgctgg cagaacccat aaacaagcca acaccgattg
     1081 taccgcccaa ggcgatcatc tgaatatggc gcgcgcccag gcccctcttt aattctttat
     1141 ttgccactcc tcttcctcct cctaacataa atgagaaaac agcagacctg cttgccttca
     1201 catgaatcag cgataacaat cagaaaattc aaacttaaaa ttgttatata atctcctaaa
     1261 ttacttattt catcataata aatttctctg aaaaatacaa ttgttttttt caggtaaaca
     1321 cctttgttca gagttttgaa tcgttcactt cttttaaaat cttttatata aaaataataa
     1381 aattatttga atattgaaat taatacaccc cttagattct cataaaaaat aagctgttct
     1441 acatgaacag cttacctaat aattcacacc cgtttgacgc tttaatgctt caagccaccc
     1501 ggtatctccg gtcccatagc tcttgctttg tcccacatct atcagagatc cattgctgta
     1561 atcaattgat aggatgaaat ccggaatggc attatacccg gcttccgcga ttttactgag
     1621 ctcagaacga tagtaagata tagcataaga agccgtttgt ttctgcactg gatctttttc
     1681 aagctcttcc ttatatactt ccattaagtc acgtccctca ggcgtgacgt accgcccatc
     1741 aatcacttct aaatccttca aatggtagcc tgtaacttca tacatctcac gagcagcctg
     1801 atacttttga taggcctctt cggaaaattg tgctgaatca ctgctttggc ttttcatgat
     1861 gtgcaaaaat agttctttgc tgttgtctcc agattgcagc acttgctcaa tttgcttgat
     1921 cagatcctga tcgtctgtcc cgcttacccg cacctgatag tcaatcggtg tgattgtaaa
     1981 cgtcagctct gtcccctctg gaatatgaat atggtttcga ttcaacagta cttgcagctg
     2041 ctggttaacc tgtccccgct gatacacctt ttcattctca gcttccactt ccccatgaaa
     2101 tgtgacattc cgaaacacag catcctgaag gttatagttt tgcgccttcc ctttgaataa
     2161 ccattctgtt tcattatcgt aagcggcctg tctttctgca gctgacagat cacttctgaa
     2221 ataaggagac tttgaatttt ggtacttatc cttaatatag cctaatggat cagactttgt
     2281 tttattaatc gcattcatcc tgctgtattt ttcatctagt attttgattc tgatatcact
     2341 ctcagattca taggggtttt gggattgaat cactgtttct tcccctgtgt ctgtcactgt
     2401 tcgatcattc gctgattgat acactttgct gaacgccccg ctgtttcccg acacgctggt
     2461 tttagaataa ttgaactgat tgattccccc agttgaagat tgtgacttaa gcctgctgta
     2521 tgccttttcc agaactgccg ctggattttc agtcgcattc tcccgtttgg caggcgcatt
     2581 cttgctcaat atgttctgtg ccatcagctg agtgcggata aattgccgat tcagacgcat
     2641 tgaattccct cccgagtatt ctctcttatt cttttttatc ggcaaagata atgtatatat
     2701 taacctcaaa aaacatttat ttacacctaa atcgttatta tgtatgatgg aaataaaagg
     2761 aggttgtttg catggtgaaa aaatggctta ttccattcgc tgttatgctg tctgtcttat
     2821 tcacctttac gtattcggca tcagctgccg gagtcactgc tatcacagga aacaattcat
     2881 ttgataccgc aatgccgatc ggttattgga aatataaaaa tatcgataca acaatactgg
     2941 aagctggtca agatgaagcc tatttcactt ttacggctaa taagggagaa aaagtatacg
     3001 tgaggagtac ataccagagc gcgtatacag ggatgaaaat tgaaatttat gataagaata
     3061 gaatacctgt ttctcaaggg acagaagtca ttaaccctaa tacgttttct tcttttattt
     3121 atgcaaatgc agacgcccaa aacacgacgg atacctttta tgtgaaagtg tcacgaggca
     3181 cctataccgg aaacatgtat tttacacttt caattgaaga ccgaatcaaa tcaggcagcg
     3241 gaacattcca attcagcggc gttgctgaaa ataaaggaaa tacaagcctt agcccctcag
     3301 gttctgattc cagcgtgatc aaggttgatt taacaaacca atccgggata ccgcgtgatg
     3361 ccattgtaac cagagttcag acaaccgcca ctcaaacacc aagccaggga aatacacgcc
     3421 acctgatcat gacgagcgaa aacaacgaat ggcgccgtgc tcttgtaaac agctcgactt
     3481 cagggtctta tgatatctct ttgtcagatc aactcagtgt ggcaaaggta tggagtttta
     3541 aatataatac attagcgaca gccagatcga cgatgagcaa cgtaaaagca aaaatagatt
     3601 atgaatacga cgtgacaaag cagttttaac ttataccgag ccggtgatcc ggctcttttt
     3661 tattctctgt ctagaaggta aactatagtc agtacaacca agggaagtgc agacatggca
     3721 ttaaaacttc taaaaaaact gctatttgac cgccctctaa agaacggcgt tatcttaaat
     3781 catcaataca aaatcgaaga gtgcctcggt atgggaggct acggtttggt ttatttgtgc
     3841 accgatatcc taactcaaac accttatgtc ttaaaacagc ttcggccgac aaaagcgaaa
     3901 aaggaaaaag agaaagtccg attccaacag gaaataaaac tgctcaatag cattcaccac
     3961 ccgcaaattc cgggcttcat agatgagttc atcatagacg gacaggctta ttatgtcatg
     4021 cagttcattg agggagagaa tatagaagaa ttattatttt ttcgaaaaca gccgttcaca
     4081 gagcttatgg cattacaact gatttcgcag ctgcttgaga ttatagaata cctgcatgat
     4141 cgccttatct tccacagcga catcagaacg cctaatatca tcatcaatga cggcaggctc
     4201 tgcctcatcg atttcggcct tgccaaacaa ttgactcctg aagaaatgga ggaaataaag
     4261 gtacgaaaac aggatgactt cttcgatctc ggagaaacgc tgttattcct gctgtactct
     4321 caatataaag gaaaaaagaa gaaaaacggc acttggctgg aggaattaac actgacaaag
     4381 gaagtaaccc tgctgctgaa aagattattg ggcattgatg aggagtatca gcacaccgct
     4441 tccattcgcg aggatctaaa ccgggccatt caatcgatca cataaaaaaa cccttgtccc
     4501 aaaagcggaa caagaacttt ttttggatta actgctgctg tagctccggc gtttgtaacg
     4561 atgactgccg ccataacggt cgtagtgtct tcttttgccc gagctgctgc tgtagctgcg
     4621 ataatgtctg cgcctgctgc tgtaatgccg gtgtctgcga tatcggtcac tagaactgct
     4681 tgagaggtac ttaatcgttt tgatgatttt tttaaacata tgcttcaccc catttctttc
     4741 tccctattat ataaatttta taggagaaag aaaaacatca gcggggtcac tcttttgaaa
     4801 acaagaaccc cgttccgtta tcatttgtat gcagctcata agtaatcgca agcagcctgc
     4861 atgtatcatc aataatcttt aacccaagtc cctcactgct ctcattccga tcaaatccaa
     4921 taccgtcatc acgaataaaa acatcgccat gttcaatcgt gacttccatc ttttcagctt
     4981 ttgaatgcct taacgtattt tgaaaaatat tatcaaacag cctttccatc cataacgcgt
     5041 tgctcatcca tatcacatct tgatctgccg gcttatagtg cagctcaatc ccactcatac
     5101 tgtataaata atcccacttt ttcaccgctg tttctaatag ctcgtttaga cgcacttctt
     5161 catttacaat ataagagctt tccagcgtct cagcggaata tagattgaat tcattggtta
     5221 attccgagat atattcgatt tgctgataca atgattcgaa tacagcctga ccatgacatt
     5281 ggtcttccaa ataaaataaa tgcaacctga gagccgttaa aggtgtatta atgtcatgcc
     5341 gcagtttttg caaaagctcc tttttgattt cctcttgctg tctcagctcc agttcacgat
     5401 atgtcgtccg ttcaattaac aaattgaccg acttgatcag ttccccgatt tcatcagcac
     5461 gcttcacttc aattttatcg ggcacccttt gatcactcgc caaatgccga atggtttgat
     5521 ttaatagatt gattttatgc aacagagaat gaatcgactt tgaaaataaa aaagctaaca
     5581 ataagagcga tatcaaaaat acaacgatca ttgccgggta cgcaaacgac ctgtgaaagg
     5641 gcataccatg attcatcggt ttaaacatgc tgtcataaat aacagacatc aaaacactga
     5701 ccgccagcaa cagcatcgga acactaatga cagccgtaaa caataacaac tgatattttg
     5761 tcttgagctt catttcttca caacggtatt cagccgatac ccttctccat atatattttc
     5821 aatcatctca cccgcttgat cattgatttt agctctgatt tttttaatat gcacattgac
     5881 aatattcggg tttctatctt cgagctgcca tagatattca aagaaatgtt cctttgtcag
     5941 gatactgtct ctattttcat ataaataaaa gaaaattttc cgctcaatcg cagtaaacaa
     6001 tacctcatca tgcaggcttt cattgaacac ttttttcgtt accgcatcaa tatacaaatg
     6061 tttgatttgc gtaaaggtgc cataatgatg ctcaagcata ttccgcattc ttaatagcag
     6121 ctctctcgga tcaaagggct ttaccatata atcctcgccg atctgtaaac cttgaagctt
     6181 gctgtccata tcattacggg ccgaaagaaa aattaccgga atgcccagcc ccagctcttt
     6241 gatttttgca gacatttgat acccgtcttc acccggcagc atcacatcca taatgaccaa
     6301 atccaccttc tgaatcaccg aaagcacatc cgctccatct gttttccata tcacacgata
     6361 tccctcacgc tgcaaaatct tttgcagcaa atcaccaatc atcacatcgt cttcaacgat
     6421 taaaatatga taacccttca tcctagcgaa cctttctcat aaactccatg gacagtttat
     6481 atatttgatc aggctgatat aaataaatac tgtgtgttcc cctcagttcc tttatatcgg
     6541 cagtattgaa ttgagccgca aacacttcat aatcttttcg gttttgtata gcatactttg
     6601 aatgtctatt ttggtcagag accgcatcta aaatcaagac gggagtttcc tttggcgccg
     6661 gcagattcac agatttgctg ccgttttggt aagactgtaa aagctcatgc tccatatctg
     6721 cattaaaaaa ttgcttaaag ttaatggctt tatagatttc tttttcttca tcagttaaaa
     6781 acgactgccg tatcacctca ggattatata cagcggaagg cataaaccga tgaaaaccaa
     6841 tcgaggttaa caggtggaac cctctcactt tcaacctgtc aactccgctc aatttatacg
     6901 tgacgtactg ctggggcaat ccaatatcca tcgcaataat ggccttgatt tccttaggat
     6961 atttctgtgc ccaatacatc gcttcaatcc cggatatcga atgaggcatt aaaatataag
     7021 gaggcttatt tccgcttttc ataagcgctt tcctcgtctg ttccaatacc gtatcaatat
     7081 ctctgtcatc gtgagacact tcactgtatc cataacctgc ccgatctaca acagcaatct
     7141 tattttcttt tgaaaacttg ctgtacagcc ccttcatttc ataagcaggc gcagcaatac
     7201 ccgaaccaga cataaacaca aacgtatcct tcccgcttcc ctcttgatac acattcatct
     7261 ttttaccgtc aacatcgact actgtgcctt tttctttaag gagtgccgcc tccttattta
     7321 gctggaaatg gtgataaata aataccgaga cgcatacaag caaaaccaaa gcagccaagc
     7381 tgacaaaaac aatttttagg actttccata atgttttcat atgatgctcc tttcaccgtg
     7441 atactgaaag gatacaatat gaaaataaat ttctgattaa ctttggaaca gttttatttt
     7501 cacatttgac tttctagtca caagattcaa tcaaaaagca gctgaactaa aagttcagct
     7561 gctttttatg gttatagaac cgataaaaag tgtacccaag tggtctcatt atttatgcac
     7621 aattaactta gagaactcgc gcttattgaa gtgttattta gcaattgacc gttaacaaac
     7681 tctcggtatt tttcatggtt atttattagg tccaaatgat taccgcttcc tgtaaccact
     7741 ccattttcta aaaatacaat gttatctgca tctctaattg ttgacaatct atgagctata
     7801 ataatagtgg ttctatctcg aactagtcta tttatagatt gttgtaccaa tatttcactt
     7861 tcactgtcta aattagaagt tgcctcatct aataaaagta tttcagggtt tttaattaat
     7921 gctcttgcta ttgcaattct ttgtttttga ccacctgata attttatacc cctttctcca
     7981 ataaaggttt cataattatc tggaagctcc ataataaaat catgggcatt ggctaattta
     8041 gaatatttaa ttatagtttc ttgagataca gagcctgata aaccgtacgt caggttctct
     8101 tttatcgtgc cggtgatcat caaagtatct tgcattacat aaccaatttt ttttctccaa
     8161 acagtcaaat caatgtcttt tataggagtt gattcataat agatttcacc attttgagct
     8221 tcatacaaac gttctattaa attaaataaa gttgattttc cagctccaga aggacctaca
     8281 acagctgtta tcttattttt tggaaaacgc aaattcagtt tgttaaatac ttcagaagaa
     8341 ggatcgttat actgaaacga aatgttctca aatttcagat ccccatttcc caagttaaat
     8401 gcattactgc taatttgttt attttcggcc tcgggtttta gtgaatatat ttcatataat
     8461 ctttttgttg cacctagtgt ttttttatat tcagtaaaaa agttagacag agaggaaaga
     8521 ggtgtaacaa attgaactaa gtaaaaaatt attgcaacaa aggtacctgg tgaaatagtt
     8581 ccttccgata accttatccc cccatacccc actaacaata atattatcat tagtataaca
     8641 gtagacataa taggcatcat ataagcttgt atcttagtat cttttagatt aagcttaaaa
     8701 attcttttta aaatgacatt acctttccca tactcttctt tttctgcagt ataacttttt
     8761 gtaagtctaa ttcctgaaaa tgcactactt attcttgcag taaatattgc catattattt
     8821 tgtttttcta aagaaatttt atacatctta ttccccaatg gaatcataac agctaatgaa
     8881 ataggaacag aaatcaacat aagtaatgtt attttccaat ccagcacaaa cagaagaatt
     8941 aatgatccgg caactactat caattgagaa gcaaagtttg gtatcttgtc agaaataaaa
     9001 gtattcatta actcaacatc atctataact ctacttacaa tttgaccaga ttcattttta
     9061 tcaaaaaacg ttagaggtaa atctaaaata tgagaaaaca ttttatctcg tatatagtaa
     9121 gtcgcattct cacctaaaaa tgctagataa taaaaagata atccacttaa taaaatattt
     9181 atgagaaata aacctgctaa cattattgtt aaggcccaat ttactgttcc atcagtgaat
     9241 tgatcaacag tatttttagt caatattggt attaccaagg atagtatagt tgtaaatagt
     9301 aatgaaaata aaatatatac taatattttt tttggccatt taacaagttt aagcagtaat
     9361 agtaaatggt tattgcccat atgtataacc tcttagatta atcattttta tttgaatgaa
     9421 cactttcgct attaacttct aaattatttt gatcgaattt caccaaatat acaataccaa
     9481 ttgctgatga aattattaac accactttat aaggggtggc caaaataaaa taatcactaa
     9541 agatgcttga gactgcttga aacgttacag taagacaaat aacactgact gtaaaatttg
     9601 caaaagcaag atttgattgt tcttttataa actttttcat cgtctcaatt attggttcga
     9661 ttatggtcaa tgctgtagct attgtagtag acagaatata ataagctaag ttagattctt
     9721 tattgactgc gtcttcaaca acctgagcaa aaaagtttga tcctaaaacc ccaataatta
     9781 agaccaccaa tagacttaaa atttttattc ctaatctttt taaaatagaa tttaatatac
     9841 tatccttagc tattgccaat tgtacatttt cgactatcat tgaaaatatg aaaagaactg
     9901 cgaaccaaat atacatatat actggcaatt caaaagagat taattccgtt agaaatttaa
     9961 tagtgatttc tagtactgct tgtatcaatt ttatccccct ttaacttatc agaaatatct
    10021 tgtcccacga atcttgacca aaaatgaaag aaattaaaac taaggcaatt cccgtacttc
    10081 cttctaacaa acccactttt ttctcttcta caattttccc acttattaat tcataattat
    10141 tgaatttgga aaagtttaat tgagagtaaa aagttaacat ttcattaagt atatcatgca
    10201 ttttatcagc tagaaatcgg tcattagtat ctttatacat tcttagagtc aacattaata
    10261 tgccggcata tccatgacaa attgtggggg atataatttt tctatctttc tcatcacgta
    10321 aaaaaaatgt cttaaacagt tctagggctt tcattttaac tctttgatcg ttcaaagcta
    10381 tacctgataa aaagattgct cttgacacac ctggtgtacc atagcaccag gcatctctgt
    10441 ggttaaaaaa agcctcattt ctaacaactt cattttcaat tacattaggt atataataaa
    10501 ttcctttgtg tgtttttacc ttttcgaata tccaattttg aatgttttta atacctaatt
    10561 ctaaattctt tattttatag ttttcttttt tcagaatcga taaaaatgct aaaactccag
    10621 aaattccatg cgccatgcca gaattaaaat atcctttttt ataagttttt ttctcgatat
    10681 ctaaaggaag gttttcattg gatataagcc aatttggcat attacttaga gtatcaatac
    10741 tgctaactaa cagtaaatat tctgctatat catgcaatgc tttttttaat gaaatatctc
    10801 ctttatttga tatttgatca aaatgcaata gggttcttcc aacacctgtc caaccactta
    10861 taacatcata ttcagaagcg gacactccct ctttctttag cttcaacaag tcctcagaca
    10921 aataatgttt atagttttct aaaattaggg ttagcacttg atttattatt gtagtatatc
    10981 ttgttccgcc tctagagcaa gtttcaagag ccactaaaac acctgccaac ccattaaata
    11041 gggatagtga gtatgtttta ttagtctgaa ttaaggaaat taaatctgtt aaatagtcgt
    11101 gtgccacaac atcccatcca tcttcaggga aaactttatc catataacct aaaaacacac
    11161 aaattcctgg atatcctgct gccaatgata ctacttcaat tatatcttca ggattatttt
    11221 gatcaccaag tattattttt tcggtttctg acttatcttt aattgaatta gctatatcta
    11281 aaaggatatc ggttaaaaaa tctggattct tgcatttctg cattaattct ttcctttcaa
    11341 ttaaaattta gttagggatt aaaacattat tatactttag agcattatta taatttttaa
    11401 tggtatgata tgctaaccca ataactaagt tttctttgtc cctgtttatt ccatataatc
    11461 tgttacaatg catgtgtatt acactcatta taatattttt tattaagaaa tctggattat
    11521 tttctatgct cttagaatag gtgattgcag ttttttctcg tatctctata atacttgaga
    11581 ttttattata tttatcaagt ttcttattag tatagattaa gtctgccagc tcaattaaag
    11641 tacttttttt ccctctgaat ttattagcgt atttctgcgg ttttgtatta atttctaacc
    11701 atgtcatttg ctcttcaata tttaaattaa ataattttaa tagttgaaga atattaaaaa
    11761 ctccaaaggt cacttcatca atattaacat ttccagatct gttaatttgt atccactcag
    11821 aaacaatcaa tgagtcacaa aaaaataaat cttctgcaat cttatatgat tgttcccctc
    11881 cgtatctttc tatttcaggg ttgtatggat cgaaacaata ataattaaca aaaccctttg
    11941 ttctcatttc ttctaaccat tttattataa tcgggagtac agtatcgaaa atgttattct
    12001 tttcaacttt aaatctaaca cgtaaatgct gcttagggtc actatatcta atgaaaaagc
    12061 tagacttaat agtaccttta tctaaatgtt tttttataaa cgagccaagt tcatcagcta
    12121 taaattcatt ttctctagtg cctaatccat ataatttcac ataaatccat tctgtaccta
    12181 agaatttaag cctttcattg tcaccaatat atttaaaagg catttcactc tgaatatttg
    12241 tcatataaga atcaagttct aattgatgta actttgactt taaagtaaaa acgtattctt
    12301 ctatttcatt gttatgatta ttaaacaact ctttctctgc ttctaaaaaa tgtagtgatt
    12361 gattattcga aagcttctta aattcattat agataatttt aatgtgtgag atattttcta
    12421 agttcagcag aagtttatta tcaaattcta ttaaatatat aaaatcaggt accttatatc
    12481 tcttcttcca atcttttata tagtaatgga atttttctcc agagtcacat tcaaatggaa
    12541 taatactttt attcaagttc cactttttag gtgataatac aatattatta tatataaccc
    12601 tcggtttaat tggagcatca taaaagaaac tatctatatt agaccattgt ttttgatact
    12661 gaacaccaat atcaacaaga aatctataaa ctttagggcc cattgaataa ttaaacatat
    12721 gacttaattt tggtattatg attttatcca acttttttga cttaagataa ataaagttat
    12781 atgttgaccc aacgtataag tcagacaacg caattgagtg cttattatct ttggacgaat
    12841 tacagctaaa agctatctca taatcaaagc atgtttcagc atttataatg ttagcagttt
    12901 ttccatgggt aggataatac gtaacctctg caaaaataac atctttttct atatgtgaga
    12961 attgttttat gtactcttta tcactttcac ccaaaaaata tttgaatctt ccatatgttt
    13021 gaaaaagaga attagaacca cagttaggat ttaaatagag tttattttct ttgtgttcat
    13081 caagtaaaat attaaaataa agttctaatt cttgtgatac cgcaatgtta tttaattctt
    13141 ccgagttaaa taaatgttta atcttttcat catctaattt aatctcatga tttttggata
    13201 aactcacctc cgcttgccaa gaagatataa tattttttat cctatgaaat tcattactcg
    13261 gttctggttg tgatggttta tgcctgtttt catgatattc aggtggtaaa ccaataccta
    13321 attcttcatc tatgagttcg aggagaggta cctcttgaaa aataccatat ttatcaatga
    13381 actcatctct ataggcttct aaaggttgga aagagtttac tgatcctaat agagaaagaa
    13441 tctcagctag cttctctata ctatcttttt ggttattatt aatatatcgt tttttatttc
    13501 tcacataata caaatctgtt ctaaggaaat catccccttc gtatcctatt actcgcattt
    13561 cctttttgat tttctttaaa atacttatac ctaattcccc agaagatttt ttgtattctt
    13621 caatcgattt ttttaatcga actaaataat tcaattcttc ctctacatta tgcattttac
    13681 taattatgtt taatatattt tcaaaaggat cagaattaac aagagatgtt cttaagttag
    13741 ttataataac ttcatttttt aatagactat ttaaaaaatc atttgatatg tcatcagtaa
    13801 cactatatgt tttatttata ctatctctta acgtagagta attgataccg aattctgctt
    13861 gcgaatagac ataatccatt actgctgtct ttctaagggt taacatttct aatgactgat
    13921 cattatcgtc actgtgtaat agactttgat aacttaattt gattctatca ccgtgattat
    13981 aaaccagtga gttattttcc acagttaact gctcgagaat actaaggtta ctctctaatt
    14041 ttcttattaa gaaatagatc caacacatat ccaaacgagt attttttata acttcagaat
    14101 ctttagttaa atattcatcc tgacctgaaa atgtttcaac cccaatacct gaaaaaaggc
    14161 caaatggagt tggtcttgta ctcattctta ttaaaaactt tagcatacta tcaataacac
    14221 tcttgcgctt tttctttttt aatttttcta tatttaaaaa agaattatat agtggttcac
    14281 ttgcaaaata aatggcctct gctatagtgg gattagtgtt taataagtta cttatcttcg
    14341 ctatgtattc ctcttcgtta aattcattat caaaagctaa acactcttta taaaacgata
    14401 agtccaatat cggctttcta tacataaaca agtctgagct taaatatttt gtattcattt
    14461 ataacaatcc tttgataaat tttattacac tataagcatt tatttcgaaa atagaatttt
    14521 gatcttttac tcgtgaggag tttttttgga ttatattaag aatttctttt tctgataggt
    14581 gaatttgctt acatatcaaa tattcagtca atactaatgc tattagactc gaaaacatag
    14641 ctgctgatat actagttcca catgtaactg tataaaagtc cggaagccca attgcttttt
    14701 caaactttgt ttttggaaaa tttgtgggat gtgcaactat tattaagtct gtaacattat
    14761 ttgtttcatc aagttcccct gatggtgcag caaatcgaat aattgaccca atatttgcgt
    14821 aagatgaggt gtaattattt ttatttgttg aggtgacata gttaattccc ttaattgtag
    14881 ggtataaact tgtactcttc atatctaata aaactccttg attccctgct gcccctacaa
    14941 ttattatgcc tttctttctg gctttatcaa tggcctgctg aagtttattg aatgctcctt
    15001 tatttcccaa tccgaacata gtaaaaacat gacttaaatt tataatgtgg acacaatctt
    15061 caatggcttt taaaatagca tgtattaccc attctatttt cccaaaacca tttctatcta
    15121 gaactttata actaataatt gtaattccgg gagctactcc tttaacttga tttttcccta
    15181 caatcacact aataacagct gtaccgtgcc catatagatc ttcattaaaa ttctcataat
    15241 caacgaatga acaagatttt tttttatcaa tatttccagt aatctcggaa tgattaggat
    15301 catacccact atcaattaca gctatcttaa ttaaagggct cccaacttga agatcatata
    15361 gcctatatcc atttgttact ttataagagt tccaagaaaa ttggttaggt aaagcatttg
    15421 tagtcatatt catatttatg gaattgttta ctccttgtct ttagaagaag agggagtttt
    15481 aatatagtat gtattttaac tccctctgct catcccctaa ttagttacag ttactgcaag
    15541 agcctagcga acatccacaa gtaaatgttc tacatttttt cacagactgc acaatagttt
    15601 ttccgattgt agcccaagtt tgagcagaaa cctcactagt agattccatc tttttattaa
    15661 tgtctaggtc aaaaatatta ttcttctcca tttccatttc ctcctttttt tgatactttc
    15721 aaccggttgc aattcaatag tactatccca aaaaaagtta gtcaatactt tttttgggac
    15781 attttttaat tatttgctaa ctaattgtta taattcttct tacggttact tttactctct
    15841 actattacta ttcgactttt gatgtatcct cagtaatctt attagccaga tgtttaagtt
    15901 atcgttacta aacttccttt aatagtttta aaacgattta aaattgatct ccttcagttt
    15961 ataagtatta aaaaaccttt tgatctatat tccaaagggg ttaaaaatct tactccacag
    16021 taacactctt cacaaggtta cgctgcttat cgacatcaca accgagatgc agggcagcat
    16081 tagtaagcaa tcagctgcaa tcgacaacgg aaacagagca agcgctgtgt ttacttccgg
    16141 caatacgaat ctgtcatccg cattgtctag gcctttcagc gagatgatgc aagtgtttac
    16201 tccccaagtg gcaacttcct tgacgtttac gcggatgttc aggtttacgt tctcttgtgt
    16261 ttccagtgtt cgatcaaggc aatcgtactg tacttcagct cgccgcggca aagccttaag
    16321 aaatctcatt cagcttcagt gcgccttcga cacatacaga acgatgtcgg cccttggagg
    16381 gctcatgcat ggactgactt tgaacgctaa aaaaacaccc gcttgtataa cgagcggatg
    16441 ttagatcttt cgaaattatt gattgatatc ttttagcgtc tgtttgggtt gtgaatgaaa
    16501 aatcctcaat gatgtaataa tggcaatcat aatccctaac gcaccaaccc aggtaatcga
    16561 ggccaatgat acgttttcca caaaaacccc tcctatacct gcgccgaccg ccatggcgaa
    16621 ttgcatcatt gactgattca tgctaagcaa aacacctgac atttccggtt ctattgtagc
    16681 caggtgaaat tgctgtgtcg gaccggtgga ccatgcggca aacgaccata atatgagaat
    16741 catcaacact ccgatatagg aatgagtaac aagtgacaga agaatcagtg tgacgatatg
    16801 caacgtcatc ccgccaacga gtgtaaaggg cactccccat ttatcggtgc tatatccccc
    16861 aaactttgat ccaaccaaac tggcaattcc aaatataagc aaaacaccgc taagcaactt
    16921 gccgtttata cctgagatgt tcaagagata cggtgacaaa taagtgtaag caacagaata
    16981 tcccccgagc cagaagaaag tgattgataa tcccatagcc actttccgtt ttttgaaaag
    17041 agcaagctgt tgaagcaaag gcacaggctt atccccttca gtatgcggaa gagtaaagaa
    17101 aataacgacc attgcgatca atcccaacaa agcaattgct ccaaatacag acttccagcc
    17161 taatgctact gctatcattc ttccaagcgg aacaccaatg attaaagaag cggtaaatcc
    17221 catcacgacc gtagcgatgg cacttccctg cttcccttcc gatgcaatct tagcggcaat
    17281 cgttaatgcg gtgacaacca ccacacctgc tcccatcgcc ataatgatcc gcgctgcaat
    17341 aaaccatcca taaccaggca gtacaaaagc caggacatta ccgaacacaa acaaacctag
    17401 ggcatacatc atcaatttgc gtctatccat acttgctgtc aacgccataa gtacgggtgt
    17461 agaaagagca tatacaagtg agaaaatggt aataagctgg cccgcggcag ctaaagtaat
    17521 cccgagagta tgagcaattt gatccaaaat tccggaaatg atgtactctg aggttccaac
    17581 taaaaagctg acaatggcta aaatataaat tttccaagtg ttagacataa aacattcact
    17641 ccttaattat taataaacat atcacgaatt atcgatatgt tgttataaaa aataaacaca
    17701 tcgtaatatg tcgatatgta tggtgtaaaa ataaacatct tttgatgttt atttttatat
    17761 ctctgtttta agaaagtcag caagtttctc aatggcttct tcatctcttt tgtaatacgt
    17821 gtactttccg atacgctccg ccttaatcaa gccggctctt aaaaggatgg taagatattg
    17881 agaagctgtc gattgcgtca ttttcaattt gtctgttatt tgactgacac ataccccgat
    17941 tgtgttcata tcaatccctt catggggtgc aaaatgacga tcgggctcct tcagccattg
    18001 taaaatttgc agccttgatt catttgataa ggctttgaat acttcaattg gttccatatc
    18061 gattattata tcgttatatt tcgatatgtc aatccgtttt tttggatata tttaattaaa
    18121 ggtttatctc tgactaattc cgtgaaatga aactgaagac agcatatcaa ttttgttcac
    18181 cgcttaaatt tatcagcaag ctttacgaaa ttggtctcat aatcatttca caaaacactt
    18241 gggggaaccc agcaggtgac aaggatgttt tcaattgttc aagtgactaa tcaccagcag
    18301 caaatttaga tgtaaaaaac atccgctcat aacaactgcg gatgttagat ctttcgacag
    18361 gaataacaag tcagtgtact atgaattgac atctctttat gtccgcttag gttatgaata
    18421 aaaaatatta caacttatga ataaccagaa tgccttcagc cctctgctgg cttgaatatc
    18481 agtgatcata aaacatttac attaaagatt tttctctaga tcattacata atttaaacac
    18541 catcactcgt tcacctgtcc gggagcttaa atcagtatga aaacttttca ctttttctcc
    18601 ggttattttt aagataatat ccttaaggcc ttctatacct gattcgacta actccgaacg
    18661 agtttgtttg atagataaca taccctcttt tgatccacaa actacatatt cggctggtgt
    18721 taaaatccct tttaaattga cgatgatcat gtcccgcagt atatcagtct taacagatac
    18781 agacccccgt ccaagataat ccttctccca ttgagtgatg gacttactga tctctgattc
    18841 aatagaaccc ttagactttt tcatatctaa tacatctcct gagcaaaaaa attggcatat
    18901 tctatttgtg gtttcgtctc attaatattc tcttacaaca tatccttcat atacaccttc
    18961 aatatccaaa tcagttttac cgtttcttgt gaccactatc attttggata acatattttc
    19021 ttccatcata gagtggacat gcaaaaatcg aacatttcct gaatgggttt cctcaacttc
    19081 ttcataagat ttaagatgat aaaaatcaat tgcttttcta attagttttt tcatacattc
    19141 catattttca cgatcaaacg agttcatgtc ctctattgtt ttcgtgacaa aatcagttaa
    19201 attagcgctc atacaatctc cttagaactg ctttctccat atatgggtgc gtttagaagt
    19261 taaacctgca tttcatcata acaagcaatg atcaggtaag gcttgacctg ttttaacatc
    19321 aggaacctcc acgattgagg gttttccatc cttatgatga acgaataaac ctctaacttt
    19381 aacatatgac ggcactaggg gatgatgtcg aatcatatca acactttttt caatggtgtc
    19441 actgctattt tcatttagcc attcatcgac cgtaccacct aaaaattcag gcttgcaatt
    19501 ttgaaaaaga taatccaatg tttgtatttt atctttcatt gtttcaagtt gagttagtcc
    19561 attacctgcg gaagtcttct tatcttttgt tcctactaca aaaatctcct caacatcttc
    19621 ctggtaaatc gcaaaaataa cagacctcat gatttctcca taaggatgtg aaataccggc
    19681 accatagctt tgtatagtca acatattctc tgcagaagtg ttagtcgctt cttgtaaaat
    19741 aggctccaaa ccgttttcaa tatccgtcaa aaataatact tttttatttt ggtttacatt
    19801 catacagcac acctcttcct tatgtttatc atttttgtat tgagtaacaa atccatttga
    19861 taaatgctta gattcatcat taccagcttt cccaacatcc ttctggatca agactagcca
    19921 gtcggaccca tccattttga actttttgca gaaatgctga atcattattt aataaccgtt
    19981 ctacatattc tctaggtgct tggatgagta tcaataaacg aagaggagaa tgataggcct
    20041 cgtgatctga ttccatgacg gattgccaag gcagtccggc taacaaatcg cttgcattcc
    20101 cctgcataac gccgagacct gcagtaacgg tttgagttgc tttatttccg ctgccataat
    20161 aatgaggtgc taccgttgat gcgtaatatt gtaaattaat ccattgggct acagttccag
    20221 gtcctgcaat aatatttgct aggagttcac cgctttcatc ctgcttccaa tcataattat
    20281 ggagaaaggc tctgccttcc aaatcacaat cctgagttag ttcacgttta ccgataataa
    20341 aagcggcatt acgagccagt ccccattccg gacgtatctc actccaatct tccgcaaatc
    20401 ggtttgcctc agccttcgga ttttttagct tcgattggaa attcggtaat tgggccagac
    20461 gttctgcgtt tacatgatgt ctcactttcg gcatcacggc ttcaatttgt tcaaatgctt
    20521 cttgtgcagc ttcggaaagc tctggtacat aaagccaatg taattcatct actgttgtat
    20581 tatgttcagc tgctgcaaaa accgtatcct caggaatttg aattccttca gctaaaagag
    20641 cttctcgtac ctctgataga ttacataaag cagctaaaac tctagcattg aatccacctg
    20701 ccgctccacc gcaggcacca caatcaaggg ctgcggaata aggattatta gtgctttgac
    20761 tgccatgccc gcagatcacg accaagggtg cgatgttttc tgttaacccc atcattttta
    20821 atgcttgacg agcatagttc actttttctt catcagtaaa acccacaggt atttctgcct
    20881 ctgtagtatc atgatgaagc gagagttttg tatcagcttt gcgcaaccaa gcctcacgga
    20941 gattacgaat gaaacgaccc gcctttcttg gcacaaagct acgggctgcc atttgcagag
    21001 taagccaagg tccacttagc tcaggcagta gtaagctcga aagcgcattc tgcttcatcg
    21061 ttttaaaggt atggcttaaa gaatgaattg cttgcttccg ttgattgtat tttttgaata
    21121 catcctcatc tgcgaactct tttattttat tttgcggttt ttgtatgatc ggcaaggaag
    21181 catgactgtg tttactgcca agttcacaag ttgcaatcgg caccccgaag aaaccagcaa
    21241 taccaatcgt ttcaaacggg ccttcttttt ctagatgacg acgaaaaggt tctgatcgta
    21301 catcgatgca gaatgctaat tgagctaatg cagatttttt acggccggtt tcacgttgtt
    21361 tcgagatgat cttctggctt aatcgatcag tgtacgtttg ttcccaagct tctaaccaaa
    21421 gtttcttgcg aagtttctca tcaaagctgt aggcaaatga taaatattcg ttttgttcaa
    21481 tggccgtcat ctgtgaccat tcttctaatg taagcccacc ccaatgaatc caagctgcta
    21541 taaggggagc aattgaaatt gttttcttag atcgttcatt agtcaaaggt aagtatggct
    21601 ttataagagc ccactccatg gatattcgaa ccgctaaata ttctgttagg agtgcatgtt
    21661 cgtggctcga ttgctgggag cgccaaagca tcatccctgc ccatccaggt aatgaaagta
    21721 aatgaccttc aagataagtc tggatttctg actctgggat ttctagtgcg aataaagctt
    21781 tctgtaaagc caaatgtgcc tctttcggcc aaccctttac cctttctcgc tgctttttgc
    21841 taagtgctgg atcatattga atgagatgct gccaagcacg atagaaacct tcctcacgat
    21901 taggcattgt ccagcctgct tgagagtcat caagatataa tttactccac ttaatgacat
    21961 gatgatctag tatattgact agcctttcac cgtcttgatt ctctatatac gaacttagtg
    22021 gctgcataaa cacattctcg atatgatcca atccatcaca ttcacttact aatttctcca
    22081 gcttatgtga tgataaaagg tcggaaggca ggggatctaa ctttaatgca gcatgacaaa
    22141 atcgctctgc cacgtcccgt gggatgtgat aggaatgtga atcaagccaa cgctgcagcc
    22201 ccatttccac aaaatcttca tcaatctcac ctttattctt tgctgaacgg atcatagacg
    22261 cactagggta tatatcaaca tcgcgagtgt ttttcaacca acttgcaacc tgatcaaaag
    22321 gttggttttc aagtcccatc cacggattac gtgcagcaaa tgtagaaata ggccaaagtg
    22381 gcgcaatcac tcggctggca gatgtaatga aaacgttaag atccctttct tgaacatcaa
    22441 tatctgtatc tatctttttt acattatctt tcgttaatac ggatgtaatg cccatctcag
    22501 attagctcct tatgaaatat attgtttaag gtagtctggg tgactctcta ctgactttgg
    22561 ttttgcttca cctaatcgga ctaaccaaag atagagtacc gcaaaaaaaa cggaagaacg
    22621 atgacgagca acccacgtac ctaaagcact gccaaagagt aagagacata cgacaatcat
    22681 gacagctgac attggaggtt gaacactttg aaaaatggtt gtatgcagcc acttatagaa
    22741 aaggtgatga atgataaaat atacgagggc tgctcctcct aaaacagtta agccggcaat
    22801 ccggccaatt cggccctctc caaaagcgac aagctgagtc caagaaacgg acaatgacca
    22861 ccctaagatc agcgcactta ttaagtgata cccgtctcca ggagcagtga gccaaaaagc
    22921 aacacctatt actaaggata aaatccgacc agccatgacc cataaatagg atgttctttc
    22981 attagtgcga gccgatactt catgacgccc tactgctgaa ccagcttgta gaaacaacgt
    23041 agctttgaat aaaccatgta aaataagatg aataatggct gctatatagg cgcctaatgc
    23101 acactgaatg agcataaacc ccatttgtcc aatcgtggag cctactaact ggcgtttata
    23161 atcaacctgg actaaactaa ttccagttcc aatcaataca gaaatgccag caagcagaag
    23221 taagataatc gaagcgatac caccatgaaa tagaggtgaa aatcgagtta gtattattcc
    23281 tccagcattt accaaacctg catgcataat tgcagaaact ggggttggag caacaataga
    23341 ctcaaccaac catctttgga acggccattg acctgcagga atgatcaccg ccagtacaat
    23401 caatagctga atccctgttc tctcccattc tcccagccca gctatacttt catttgttac
    23461 aaccaatgat aactgccatt gacctgtggc atgaaaaagc cacatcatcg caaaaaacaa
    23521 agaaaaccaa cttaacaaaa ataaccggcc agaaattttg gctgcttcac tagccacttg
    23581 ccaagcactg tttaacctaa taagtaaggt taatccaaca agagtcgctc cccaaaatag
    23641 aaccatcaag cggagatcac cacttaacca tgtcatagaa gcagcacctg ttgtgaaagt
    23701 aaaaagcgca aaatattttc gataagatcg atcccccatt aagtaacgta cagaaaaacg
    23761 ctgaatgatg aatccaattg caagaacaaa gaaagtcatt aaacaagcta aggaatctaa
    23821 gtgccaaggg ccaacatttc cactcacacc actattggca agaatcagta aggaaaccaa
    23881 aagtggtaaa gccaagatcc caatatgaat gcgaacaaaa ctcaagggta ctcgcggatg
    23941 taaaaacaat agtccactaa tcccagaagc cataagcata ataaaaaata atgttaataa
    24001 tgatgacaaa ctcagcgaaa ctaacattct aaattctccc ttttttaaaa ctcattattg
    24061 gtcaaaagac ctttcaatca gatcatattt gtctattatt tatttcaatt tttatttatc
    24121 tctatttttt tccaacaaaa aagccgacaa cttcaaaatt tcaatgatta tgttagatca
    24181 ttgaatcctg aaaattgtcg gcttcacttc aactaacttc agcgaagttt tttgaagtgc
    24241 taccttatta ttggtcttta ctttatgcta tgttttcatt tcctttaata tagtcctgat
    24301 tatcaaataa atcgactcat gttctcttcc ttttttatta ggatactttt tcatcctatc
    24361 aatatttaaa attaaatatg aaaagaatgc taaaggccta catattttaa aaggaaaaat
    24421 aaacatctgc atcgattatt aagttacgta taagatat
//
