LOCUS       NZ_JADMPO010000001     17222 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Mediterraneibacter gnavus strain D52t1_170925_A9
            NODE_1_length_311265_cov_25.1742, whole genome shotgun sequence.
ACCESSION   NZ_JADMPO010000001
VERSION     NZ_JADMPO010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Mediterraneibacter gnavus
  ORGANISM  Mediterraneibacter gnavus
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Mediterraneibacter.
REFERENCE   1  (bases 1 to 311265)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 311265)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 27.07x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 03:23:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,493
            CDSs (total)                      :: 3,428
            Genes (coding)                    :: 3,362
            CDSs (with protein)               :: 3,362
            Genes (RNA)                       :: 65
            rRNAs                             :: 1, 1, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 6 (23S)
            tRNAs                             :: 53
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 15 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 5 of 66
            Pseudo Genes (multiple problems)  :: 9 of 66
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:46:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 294043
            Orig. end                         :: 311265
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADMPO010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17222
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..17222
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17222
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:13027](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13027
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    38..58
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.3"
                     /tool="antismash"
     misc_feature    complement(715..729)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    716..730
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    1395..1409
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.08"
                     /tool="antismash"
     gene            3713..4399
                     /gene="srtB"
                     /locus_tag="I2I27_RS01360"
     CDS             3713..4399
                     /EC_number="3.4.22.71"
                     /GO_function="GO:0004197 - cysteine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016485 - protein processing [Evidence
                     IEA]"
                     /GO_process="GO:0045184 - establishment of protein
                     localization [Evidence IEA]"
                     /codon_start=1
                     /gene="srtB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016294856.1"
                     /locus_tag="I2I27_RS01360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class B sortase"
                     /protein_id="WP_195659573.1"
                     /transl_table=11
                     /translation="MRHIGEKIILVLCIAVFGIAAMNLVEIGKEYYDGQKEYEELKEYT
                     EEEPNGQQDDPAESKAEEKTIDFAELRKINEDIVAWIQIPGIGVDYPVVQGEDNEYYLY
                     HTFCREANKAGSIFLDCRNRADFTEPCVIIYGHNMKDGSMFSNLKKYQDNAFRKESGTA
                     YLYLPEKTLQLEIMVCERVSMRDGVYALEYNMTCDWPEEIILSTCSSSSDIRLILRCRI
                     AEVVHH"
     gene            4625..4792
                     /locus_tag="I2I27_RS01365"
     CDS             4625..4792
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2I27_RS01365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_195659574.1"
                     /transl_table=11
                     /translation="MKKRDEKRSFLVKNEKCLKLNEEELQKVIGSGNSQVRYISDEYIQ
                     ARILKMRINI"
     gene            4908..7076
                     /locus_tag="I2I27_RS01370"
     CDS             4908..7076
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="I2I27_RS01370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_195659575.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.9e-37, bitscore:
                     121.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKKVRFIEQSEHSECGITSVTMLLNYFGIKVSLNSLRDKYGVPK
                     GGNTLFHLKKIIQDYGIETSGYKVEKLDFFKENNRPCILFWDNRHYVVFEKITFNKVII
                     VDPAQGRKKYSHKEFLEHFSYTVLIPTDINKKVANSIKDDKRENVLFKLFMEQKFKIIG
                     LIFLTIIIQFFSLWIPIITQRAVDNYVLLTHDLTINEILFVIGIAFGTYYFLQVGRTLI
                     VAKFQNYFERYLMTKFMKKIMALPLNFFVNRSTGDLIFRSNLTTYIQQLLSSQLVTTII
                     DIIFVIAYLYLMISYSVQLTIISMCGISIIIVSSFINTKRYQTLTDKELLLHSKVHRTL
                     VELFEGMETVKSIGAEKQFYEDWEKNFSEQLKVQMSKNRATGFIGNISTTSQFTLPLVI
                     IGVGIYGIKNNTLSIGELISFNAVASAFVAPIITIMGAFSSILLLRSYFGKLSEILEQD
                     ILTDDEKESFDDVYETIELKNVSFQYSKFEKPILKNINLTIGKNEKVAIVGPSGSGKST
                     LVKILSGLYSPTEGEVLLNGRNIKGVRQSSLRKKVSMVNQNPSIFNMSLRDNILMNKTE
                     INDEVFLKAVDDARVDEIIQSLPMGFETQISEGGMNLSGGQMQRIAIARALVNQPELMI
                     MDEPTSALDNISENYIMNRVKEYDFPCVVVSHRLNTIQHFDRVIVMYQGSIVEEGTHEE
                     LMKNQGIYSYIYSGNLNNGNLKGEQAVG"
     gene            7069..8472
                     /locus_tag="I2I27_RS01375"
     CDS             7069..8472
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="I2I27_RS01375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_195659576.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.1e-36, bitscore:
                     119.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKRIKVVAAIIMLTIMMGNEAFANDLLKESEDIPEVYNGVNGTN
                     EEKEDSFEVLLDKQYSIEQFEQTVTNLYPGVVLSAVEEIMLIHIELPESVEKEEFLNNK
                     EIREFIYAQGELPDISIPLNPLGTVSLNKLNVDVLKNLRARMTDEEMFDAMAWHVDEIT
                     NNRKSLDITKGKGVKIALIDSGVDISHPVLAGKINMQDSYSYVTNEPSIRDDNGHGTGV
                     AGVIAQIAPESVITVYKVIGEETGESDWTISAIIQAANNGNDIINMSLGTYKCDDVESE
                     LLTIEAYERAVQYAEEKECLVVASAGNKALDLDQYYENEGIKHLPGGIEAAITISSVHK
                     NSLATYSNFGSNIDFSAPGGDLAYVDGLLDLNQWIYILYPTTLDNGLSSLGVPQGYTFN
                     CGTSLSAPAVTAGIADLLSYSLENKQDLNMKQIVEVLIEGANDIGTPGKDNCFGYGVAN
                     IYNSIVGMK"
     gene            8573..8761
                     /locus_tag="I2I27_RS01380"
     CDS             8573..8761
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2I27_RS01380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_195659577.1"
                     /transl_table=11
                     /translation="MKEKNIKEKHLECEVPEKEHYGKKFEDLTPEEMERIQGGGDVIPE
                     ELTKSLGMILSINGYKC"
     CDS_motif       8573..8689
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKEKNIKEKHLECEVPEKEHYGKKFEDLTPEEMERIQGG"
                     /locus_tag="I2I27_RS01380_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8690..8761
                     /prepeptide="core"
                     /locus_tag="I2I27_RS01380_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.10"
                     /molecular_weight="2426.8"
                     /monoisotopic_mass="2425.3"
                     /core_sequence="GDVIPEELTKSLGMILSINGYKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKEKNIKEKHLECEVPEKEHYGKKFEDLTPEEMERIQGG"
                     /leader_location="[8572:8689](+)"
                     /alternative_weights="2444.9"
                     /alternative_weights="2462.9"
     misc_feature    9423..9437
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.38"
                     /tool="antismash"
     CDS             complement(9548..9658)
                     /gene="allorf_303591_303701"
                     /locus_tag="allorf_303591_303701"
                     /protein_id="allorf_303591_303701"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLGLALIHETSYGGIRYEKRQTLKNYNPYTCFYKII"
     CDS_motif       complement(9617..9658)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLGLALIHETSYGG"
                     /locus_tag="allorf_303591_303701_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9548..9616)
                     /prepeptide="core"
                     /locus_tag="allorf_303591_303701_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.10"
                     /molecular_weight="2819.3"
                     /monoisotopic_mass="2817.5"
                     /core_sequence="IRYEKRQTLKNYNPYTCFYKII"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLGLALIHETSYGG"
                     /leader_location="[9616:9658](-)"
                     /alternative_weights="2837.3"
     CDS             9688..9888
                     /gene="allorf_303731_303931"
                     /locus_tag="allorf_303731_303931"
                     /protein_id="allorf_303731_303931"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRNRIITGFRNMAASIYNSDISIPISNLFCSPPPGCYLPCSKITL
                     FKNIYCKMKYNHNKMKKIFDI"
     CDS_motif       9688..9732
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRNRIITGFRNMAAS"
                     /locus_tag="allorf_303731_303931_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9733..9888
                     /prepeptide="core"
                     /locus_tag="allorf_303731_303931_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="5838.0"
                     /monoisotopic_mass="5834.0"
                     /core_sequence="IYNSDISIPISNLFCSPPPGCYLPCSKITLFKNIYCKMKYNHN
                     KMKKIFDI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRNRIITGFRNMAAS"
                     /leader_location="[9687:9732](+)"
                     /alternative_weights="5856.0"
                     /alternative_weights="5874.0"
     misc_feature    complement(9837..9849)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     gene            10001..13027
                     /gene="lanM"
                     /locus_tag="I2I27_RS01385"
     CDS             10001..13027
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="I2I27_RS01385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_195659578.1"
                     /sec_met_domain="DUF4135 (E-value: 1.2e-86, bitscore:
                     285.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4e-53, bitscore:
                     174.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKLVYAASIQERADILSLYYKDTNVKDNLSKWMSRKSLCTEEL
                     FDLSLQEKQMERKSFNLAIKSLDSNDIEVISKEIKRMIWYKKAHEILEDDKAYSTTPDI
                     IDFSYAIRPFLYYLKKQIEQIKAIGFTISDVEAFYIHLGQEFIQIAAKTLVYDLYEQKK
                     KFAFKGKTSNDRFVYYMIKRFGQKTSLMEFYEDYPVLLRLLTERVLFHADNFKEFIRSI
                     KESLPDFEKTFSLSKPYRLSNISVGAGDSHGKGKSVILFDLNDQRFAFKYKNLEIGERF
                     NSFLEYIERQTGKEFFKIKRIIKRNYCIEEFVQRKEVKSEEDIRKFYHRFGEYVALAYL
                     LCGNDFHYENLIAHGGFPVLIDIETLIQNDSPIKYADNPYVSLSLKKFNSVLGSALLPF
                     KVYGNRIEPIAEGGSKGQGIRISAFDGKKQKSPYKGLSLINENTDEVRFDYVEYELEGA
                     NNIPVFNGKEVDAEKYKYEVVEGFKEICTYFLNNKYKLISVVENIFSNVIVRNVIKTTQ
                     KYVDMLGYGYHPKCMMDYIEREKLFENLWAFEYKNKSAILSEIKDLLVNDVPIFFNNTS
                     AKDLITSDGKVIKEYYLQTAIEHVKNRIISFSNNEYLYQKLRLELSLGIYKQEIARFYM
                     GDSVSTALEKIINIIHNRAIYDEKSNQVAFEDFIYESDGTLDYNALNAEFYDGLSGIYI
                     FVLYYAKRYPDEKIKLLKSALEKSLFKLPNKKAEYHTLSAYIGKYSLLYPLYHKYKLEG
                     NDEDLLLAENLIKEIEYEIGENVEADWLNGVSGLIQVLINYYKLTKKTSFLKKAEVLST
                     VWNKKEIKFCGFAHGFSGIIYAAYSLYCETGKENYSKRVEEYLFLEDQYIKGKIWPDLR
                     EGKNATSHWCHGTIGIGLTRLYLLKHGYQNEQVWKDFLYCLEDALSTKCKETGLCHGEM
                     GRFLFLKEAQQLKSVPKSLQNKIDKSLREILQDVLENGIVIGAFEKQCILGLMTGITGI
                     GYGLLKEAEINIPNILCLE"
     gene            13165..13356
                     /locus_tag="I2I27_RS01390"
     CDS             13165..13356
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03893.1"
                     /locus_tag="I2I27_RS01390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_243271751.1"
                     /transl_table=11
                     /translation="MMKDNKKELNVITGVAFDDMSIDEMAEVQGAGDVEGEVTTPICAV
                     AVTASLSIQVAKTLKGKC"
     CDS_motif       13165..13257
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MMKDNKKELNVITGVAFDDMSIDEMAEVQGA"
                     /locus_tag="I2I27_RS01390_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13258..13356
                     /prepeptide="core"
                     /locus_tag="I2I27_RS01390_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.10"
                     /molecular_weight="3081.6"
                     /monoisotopic_mass="3079.7"
                     /core_sequence="GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MMKDNKKELNVITGVAFDDMSIDEMAEVQGA"
                     /leader_location="[13164:13257](+)"
                     /alternative_weights="3099.6"
                     /alternative_weights="3117.6"
                     /alternative_weights="3135.6"
                     /alternative_weights="3153.7"
     gene            13442..13855
                     /locus_tag="I2I27_RS01395"
     CDS             13442..13855
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028244.4"
                     /locus_tag="I2I27_RS01395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_195659579.1"
                     /transl_table=11
                     /translation="MANVNIENVIKHIDFQKIKEEKKNGKSLEEILKGIDLKPIIREEM
                     VKINPDVQDEEIESVVKEIDLIKVLGSILENENVSKEIAGKFFEDLSEEEMTMLQGAGD
                     VDVEVTPTITTSSTPCIGAVSAVTGGILSWAKC"
     gene            14028..14783
                     /locus_tag="I2I27_RS01400"
     CDS             14028..14783
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015325.4"
                     /locus_tag="I2I27_RS01400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavodoxin family protein"
                     /protein_id="WP_195659580.1"
                     /transl_table=11
                     /translation="MKKIVALFGSRRKNGNTVSFVKAILGYLPKDECDIEYIFPQDFKI
                     SPCIGCGNCFEQIQCIAKDELYILQKKILDSDLLIVASPVYLHYMSADLKLILDKCSWW
                     THTLRLQGKPTVVLSTCDSNGHRTVIEPLSKIITYMGGNVIATSNASQYPERLNNNTWL
                     NSVSIEISQRIIRYLYLPPQSNVFLEEYFLQLKKNMKLKSQFFDERKIENGEVNYWKNS
                     GMLEYENFSDYLLDIAKVKVTKKECIKQF"
     gene            14860..15123
                     /locus_tag="I2I27_RS01405"
     CDS             14860..15123
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2I27_RS01405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_195659581.1"
                     /transl_table=11
                     /translation="MEKKTKILSIVIQIALFLAFIGFFFSLFIGNEKNISTYTNLILIF
                     ACSNYFFLARQKLEDAYLNIFVRINGVLLVLWIVIAVIHLFV"
     misc_feature    complement(15311..15326)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     misc_feature    15372..15385
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.81"
                     /tool="antismash"
     misc_feature    15711..15729
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.94"
                     /tool="antismash"
     gene            15770..15970
                     /locus_tag="I2I27_RS01410"
     CDS             15770..15970
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000903073.1"
                     /locus_tag="I2I27_RS01410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_322099967.1"
                     /transl_table=11
                     /translation="MEDTQIHVFRAKKRMTQQELADLTGVSRQTIMQLEKNKYNPSLLL
                     AYTIADVLDATIDDLFIISTK"
     misc_feature    complement(15972..15987)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 22.99"
                     /tool="antismash"
     gene            15981..16298
                     /locus_tag="I2I27_RS01415"
     CDS             15981..16298
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004613730.1"
                     /locus_tag="I2I27_RS01415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_195659583.1"
                     /transl_table=11
                     /translation="MLELVEKIFDNIIVLRINGILGFVLLFTFVCYFFSREGRDERGKK
                     IIATAALTSFFALFILLNIIPMFLSWLMEDYTRLLNGIQTIYSIFLLIANVTWIILRKV
                     R"
     gene            complement(16631..16876)
                     /locus_tag="I2I27_RS17995"
     CDS             complement(16631..16876)
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (39-52). E-value:
                     0.00045. Score: 11.7. Matches aSDomain:
                     nrpspksdomains_I2I27_RS17995_PKS_Docking_Nterm.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024673.4"
                     /locus_tag="I2I27_RS17995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /protein_id="WP_195659586.1"
                     /transl_table=11
                     /translation="MVIWNKRVPSDTSIRHTVLKEEIQKIYKDSRQNYGASKITAELRK
                     SRERISEKTVGNYIRQMDLKAQWVSIDSSTRIHQAI"
     aSDomain        complement(16721..16759)
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2I27_RS17995_PKS_Docking_Nterm.
                     1"
                     /evalue="4.50E-04"
                     /label="I2I27_RS17995_PKS_Docking_Nterm.1"
                     /locus_tag="I2I27_RS17995"
                     /protein_end="52"
                     /protein_start="39"
                     /score="11.7"
                     /tool="antismash"
                     /translation="TAELRKSRERISE"
ORIGIN
        1 accaatgaaa aaggggaaac acaggtagag atcccgaaga cacaggatac ggtatattta
       61 aaagagattt ccgttcccca gggatataag ctgaatactt catctttcaa tgtgaaactg
      121 gaggcaggga aaacccagag ccaaacggtg acaaatgagg agcagaaagg aaaaatcaca
      181 atccgaaaga gcggtgaggt gctttcttcc gtatccggaa aagaagggca tcttacgttc
      241 cagtatcagt ctgcaccgtt tggagaggca agttatttta tctacgcagc agaaaacatt
      301 gtaagccagg atcagaagac accgatctat cagtctggcg agctggtgga caagctgacg
      361 acaaaggcag acggaagcat cacaagtaag gagctgcact taggaaagta taagattgtg
      421 gaacagaaag ctccggcaga tcttaccatt ggaaagactg aggcagatcg tacacaattt
      481 gtcacccttt cttatgccgg acagacagta gaattggtgc aggaggaagc agcttatgtg
      541 aatgccagac cgggagtaaa ggtgcaggca gtaaaacagt ctgaaaatga caaggtgact
      601 ttagagggcg ctatatttgg actgtatgca ggggaagaca ttaccaatgc agccggagcc
      661 gttgttgtga agaaagatac cttaattgag agcgttacat ctgataaaga cggagtggca
      721 gcgttccaag cggatattcc gattaatttt cgttactatc tgaaagagat tcaggcaccg
      781 gaattttatt atatgagtac ggaccgttat gacttcctgt ttgagtatga gaacgacaca
      841 acgtatactt acgaatttac acacacattt tccaataaag aagtgcgtgg ggaagtccat
      901 gtcttcaaga tagacaaaga tgcggaagaa tatatcagcc agggagatgc taatctggat
      961 ggtgcagtat acggattgta tgcggcagaa gatatccggc atccgaatgg gaagtcggaa
     1021 gacgtccata aaaaggataa tctggttgcg cagggtgtga tcaatgatgg aaaagttgat
     1081 tttacgaatc tgtatctggg gaattattat gtaaaagaaa tttcgccggg agaaggatac
     1141 ctgctggatg aaacagcata tccggtagaa gttggctatg aaggacagga ggttgctatt
     1201 gtacaccgga atgtaacggt aaaagaaacg gtaaaaaaac aggcttttga attaattaag
     1261 atttctgagg atggcaacca gacagagacg gatctgttgg aaggagccgg atttaaggta
     1321 ttccttattc aggatttaaa aggtgtgaaa gatggaagcc tgaaaccatc ggaaggaaat
     1381 gctttcaaag cagaggattt tatcggctat gactattcag aagatgaaac ggcacattat
     1441 tacgagaatg gtaagaaagt ttcggtggaa gaactgttta cagacaagaa aggatttgta
     1501 cgttctccag aacttccata tggaaaatat gtggtttttg aatctacaac tccagaaaat
     1561 ctccagacca tcaatccatt ccttgtaacc atttccgaag atagcaggga accgcagcca
     1621 tggcgtgttt ttgatgatag accaatccag tttttcctta agattatcaa ggaagatgca
     1681 cagacacatc ttccggtatt aaataatcac gcacaatata aaatctatga tgtgaaaaag
     1741 aaagaatatg tgacaatgaa ggtgcgctat ccggaagaaa aggaactgga tgtatttgaa
     1801 acgaatgacg aaggttatct tatgacaccg gagcagttaa agatgggaac ttaccgcata
     1861 gaagaagtaa aagctcctga tttatatgta cagccatggt atgaaatggc gttgaaagac
     1921 ggagagagcg atattccatt aaaccagttg tcacagacag gtgcttatga agatgcaaaa
     1981 cgcgatttca ttacgatcac tgtgaattcc gaaacagctt atgaagtaga ggaagaaacc
     2041 ggaaaatata ttgtcgtagt acgccagcaa aacgatgaag cggtaggaag tctgaccatc
     2101 aagaaaacag gggaagatct tgtgggtgct aagaatgtgg aagattccct tcttacaaaa
     2161 atgaaaaatg gcatcgcagg cacaataaat tctatcagtg aatttttcgg caaagaggaa
     2221 gtcatagaag aagacagcgg ctatatgttc caatatgaga agaagggagc agagggtata
     2281 acctttgaag tttatgcaaa agaaacgatt tatacaccag atggacagaa agatgaagct
     2341 ggtaaccgca aagtgttgta tgaaaaagat ggacttgttg caaaacttgt gaccggaaaa
     2401 gagggaactg tatcacttca caatctgccg gttggttcct attacctgaa ggagacggat
     2461 gttggaaatc atcattttgt tctggaccct ggagcaaaag aatttgaaat taagtatcag
     2521 ggacaggaag tagcggtaga ttatgtttct atggaacttg aaaataaacg ccagaaaata
     2581 gaacttgccc ttaccaaaca atctaaggaa acgaaagaac cggtacaggg tgccgtattt
     2641 gggctgtatg cagaggaaga tattttagac ctcacagggg aagtgattgt aaaggcagga
     2701 gaatttcttg cgaaagcaga atcggcagaa gatggaaccc tccgatttga cattgacctt
     2761 ccgcatggaa aatatatggt gaaagagttg gaagcagcac cggggtatct gaagacagaa
     2821 gaaacatgtt cctttgacgc aacctatcag aatccggagc tggaggtgat ttcccttgca
     2881 aaagagattg aaaatcagcc gacagttgta gaaatcacaa aaactgacat cacagatgaa
     2941 aaggaagtgg aaggggcaaa acttcaaatc cttgataagg acggggaaat agtggaagaa
     3001 tgggtttcca caaaagaacc gcataaagtg tatgcgttag aaccgggcga gtacatcctg
     3061 catgaagagg cagccccgga aggatatctt gttgtatccg atgttccttt cgttgtcgaa
     3121 gaaacagggg aaattcagaa agtagagatg aaagatgaac gtccatccgg tcagctcctg
     3181 attcagaaga cagatgcgga aaataaagca ccgcttgcag gcgtagaatt tgagctccgc
     3241 aataaagcta ctggggaagt agttggaaca ctggtgaccg gcgaggatgg aactgcaaag
     3301 agtgaagaac tgccgattgc agtttatgaa gagggcaaat atgtagaacc gattgtatat
     3361 gttcttgtgg aaacgaaacc gttagaaggc tatgaagcga atacagaaga ggtggaagtg
     3421 gtatttgaat atcaggatga tgaaaccaaa atcattgaag taacagaaga ggttgaaaat
     3481 actagaaaac caggaactcc gctgccggat gcaccgaaga caggggacga tacaagagca
     3541 tggattccgg ttgtaattat gagtgttgcc ttacttggcg ctttttttat agtaatccgt
     3601 atccgaagac ggaaaagata gaatataata atcgtagaat gtaacatgta atgatggaga
     3661 ttgtcacttg gaattcgagg tggcaatctc tttttttatt ggaggaaaga atatgcgaca
     3721 tattggagaa aaaattattt tggtgctttg cattgcggtt tttggaattg cagccatgaa
     3781 ccttgtggaa ataggaaagg aatattatga cggacagaaa gagtatgagg aactcaagga
     3841 atacacagaa gaagaaccga acgggcagca ggatgatccg gcagaaagta aagcagaaga
     3901 gaagacgatt gattttgcgg agcttcgcaa aatcaatgag gatattgttg cctggataca
     3961 gattccaggg attggtgtgg attatccagt agtacaggga gaagacaatg aatattatct
     4021 gtatcatacg ttctgtagag aagcgaataa ggcagggagt atctttttgg attgccggaa
     4081 tcgtgcagat tttacagagc cgtgtgtgat tatatatgga cacaatatga aagacggaag
     4141 tatgttcagt aatctgaaaa agtatcagga caacgcattt cggaaagaat ccgggactgc
     4201 atacctgtat ctgccggaga aaaccctgca gctggagatt atggtatgtg aaagagtatc
     4261 catgagagat ggagtatatg ctctggaata caatatgact tgtgactggc cagaggaaat
     4321 catactgtcc acttgtagtt catcctccga tataaggctg attttaaggt gtagaatagc
     4381 agaagtagta catcattaaa aagtatttta gacaatgtag aggtaaatta agaaatatca
     4441 taaaaattga ttattgcaag aataggtaaa aaatcaatag ttttttccaa aagttctttt
     4501 tcggtgcaaa tatgaaaaat ataattatct aaatgaaaaa aaaactttac attataaaat
     4561 aaatgatgta caatttgtaa taatagaact cataaaatga tgaaaatata aggaggtaat
     4621 caggatgaaa aaacgagatg aaaagagaag ttttcttgta aaaaatgaaa aatgtttaaa
     4681 attgaatgaa gaagaattgc aaaaagtcat tggaagtgga aatagtcaag ttagatatat
     4741 ttcggatgaa tatattcaag ctagaattct aaaaatgaga attaatatat gatgataaca
     4801 ggaaggtgaa aagagcatgt ataaaagaat aatagataaa aagaagaata ttcacttgaa
     4861 caaaaatgaa aatactacag atgtctctag agaaggagtt gaagtgaatg agtaaaaaag
     4921 ttaggtttat agaacaaagt gagcatagtg aatgtggtat tacctccgta acaatgttac
     4981 tcaattattt tggaataaaa gtatctttaa attcattacg tgacaaatat ggagttccaa
     5041 aaggtggaaa tactttattc catttaaaaa agatcattca ggattatgga attgaaacat
     5101 cgggttataa agttgaaaaa ttagattttt ttaaggagaa taacagaccg tgtattttat
     5161 tttgggataa taggcattat gttgtttttg aaaagattac ttttaataaa gttataattg
     5221 tagatcctgc acaaggtaga aaaaaatact ctcataaaga gtttctagaa catttttcat
     5281 atacagtttt aattcctacg gatataaata aaaaagttgc taatagtata aaagatgaca
     5341 aaagagaaaa tgtacttttc aaattgttca tggaacaaaa atttaaaatt atcggtttga
     5401 tatttcttac aattataatt cagttttttt cattatggat tccgataatt acacaaagag
     5461 cagtagataa ctatgtactt ttaacgcatg atttaacaat taatgaaatt ctatttgtta
     5521 taggtattgc atttggaaca tattattttt tgcaggttgg gagaactcta attgttgcaa
     5581 aattccaaaa ttattttgaa cgatatttaa tgacaaagtt catgaagaaa ataatggcat
     5641 taccattaaa tttttttgtg aatcgttcta caggagattt gatttttcgt tccaatttga
     5701 caacatatat tcaacaactt ttgagtagcc aattagtaac aacgattatt gatattatat
     5761 ttgtaattgc atatttatac ttaatgataa gttattcagt acaacttaca attattagta
     5821 tgtgcggtat tagtattatt attgtatctt catttataaa tacaaagcga tatcagacgt
     5881 tgacagataa ggagttgctt ctccattcta aagtgcatcg aacacttgtc gagttatttg
     5941 aagggatgga gactgtgaag tcaattggtg cagaaaaaca gttttatgaa gattgggaaa
     6001 agaattttag tgaacaactt aaagtgcaaa tgagcaaaaa tagagcaaca ggatttattg
     6061 gcaatatatc tactacatct cagtttacgt taccgttagt aattattgga gttggaattt
     6121 atggtataaa aaacaacacg ctgtcgattg gtgaacttat cagttttaat gcagttgcct
     6181 cagcatttgt cgcaccgatc attacgataa tgggtgcttt ttcatcaatt ttactattgc
     6241 gttcatattt tggaaaattg tcagaaattc ttgaacaaga tatattgacg gacgatgaaa
     6301 aagaaagttt tgatgatgtg tatgaaacta tagaattaaa aaatgtaagt tttcaatata
     6361 gcaaatttga aaaaccaatt ttaaaaaata ttaatttgac tattggtaaa aatgaaaaag
     6421 tagctattgt tggtccgagt ggttcgggga aaagtacttt ggtaaaaata ttatctggat
     6481 tatattctcc aacggaaggt gaagtcttat taaatggtag aaatataaaa ggggtacgcc
     6541 agagttcttt gagaaaaaaa gtgagcatgg taaatcaaaa tccttctata tttaatatga
     6601 gcttaagaga taatatatta atgaacaaga ctgaaattaa cgatgaagtc tttttgaaag
     6661 cggtggatga tgcgagggtt gatgaaatta ttcagtcgtt accaatggga tttgaaacgc
     6721 agatatcaga aggaggtatg aatctttcag gtggacagat gcaaagaatt gcaattgcaa
     6781 gagctctagt taatcaacca gagctaatga ttatggatga gcctactagt gcattggata
     6841 atatttcaga aaactatatt atgaatagag taaaagaata tgattttcca tgtgtagtag
     6901 tgtcacatag attaaacacc atacaacatt ttgacagagt catagttatg tatcaaggaa
     6961 gtatagtaga agaaggaaca cacgaggaac ttatgaaaaa tcaagggatt tatagttata
     7021 tttatagtgg aaaccttaat aatgggaatt tgaaaggaga acaagcagtt ggttaaaaga
     7081 attaaagtag ttgcagccat aatcatgtta actattatga tgggaaatga agcatttgct
     7141 aatgatttat taaaagagtc ggaagatata cccgaagtat ataatggagt aaatggtaca
     7201 aacgaagaaa aagaagactc ttttgaggta ttgctagata aacaatacag tatagaacag
     7261 tttgagcaga cagtaactaa tctttatcca ggcgttgtat tatcagcggt agaggaaatt
     7321 atgttaattc acatagagtt gccagaatct gtcgaaaaag aagaattttt gaataataaa
     7381 gaaataagag aatttattta tgcacaagga gaacttccgg acatctctat accattaaac
     7441 ccattaggaa cagttagttt gaataaactt aatgtggatg tgctgaaaaa ccttagagct
     7501 agaatgacag atgaagaaat gtttgatgct atggcatggc atgttgatga aataactaat
     7561 aatagaaaat ctttggacat aacaaaaggg aagggtgtga aaattgcctt aattgatagt
     7621 ggggttgata taagccatcc tgttttggca gggaaaatca atatgcaaga ttcatattcg
     7681 tatgtaacaa atgaaccaag tataagagat gataatgggc atggaacagg ggttgctggt
     7741 gtgattgcac aaattgcacc tgagtctgtg attacagttt ataaagtaat tggagaggag
     7801 acgggtgaat ccgattggac aataagtgct ataattcaag cagctaataa tggtaatgat
     7861 attattaaca tgagtttagg tacatataaa tgtgatgacg tagaaagtga attattgacg
     7921 atagaagcct atgaaagagc tgtacaatat gcggaagaaa aagaatgtct tgttgttgca
     7981 tctgctggaa ataaggcact tgatctagac cagtattatg agaatgaagg cataaaacat
     8041 ttaccgggcg gaatagaggc ggcaataaca atttcatcgg tgcataagaa ttcattagct
     8101 acgtatagca attttggatc taatattgat ttttcagcac caggagggga tttagcttat
     8161 gttgatgggt tgttagattt gaatcaatgg atttatattc tctatccaac cactctagat
     8221 aatggtttat cctcattagg tgtaccgcaa ggatatactt ttaattgtgg cacaagtctt
     8281 tccgcaccag ctgtaactgc agggattgct gatttgctgt cttactcttt agaaaataaa
     8341 caagatttaa acatgaaaca aattgttgaa gttttaatag agggggctaa tgatattggt
     8401 acaccaggaa aggataattg ttttggatat ggtgtggcta atatatataa ttctattgtt
     8461 ggcatgaaat agatatattt actaaacttg gtgtggttat atacttcaag tcagcttatt
     8521 tgatggcaaa attgtagaaa taaatataaa agtaataagg agttatgata aagtgaaaga
     8581 aaaaaatata aaagaaaaac atttagagtg tgaagtgcct gaaaaagaac actatggaaa
     8641 aaaatttgaa gatttaacac ctgaagaaat ggagcgaatt caaggaggcg gagatgtaat
     8701 tccagaggaa ttaacgaagt ctttggggat gattttgtcc attaatggtt ataaatgtta
     8761 atatttagaa cattaattta aaagacttta atagcatctt atagctgact tgagttatat
     8821 tattgatatt atacaaaacg ttataataat tgtttttgag aagaccgaca atttgtttgg
     8881 tcttcttttt gtggtttgtt tttagttttg tttgtagtaa atttcaatag ataggttttt
     8941 atattgtaaa acggaatatt ccatcaaaaa gagtgcgggc atgggagcat tttaataaat
     9001 ttcctactag gtttctaaca taaaatatga atggaaaatg ctgaatggct gattacattt
     9061 aaatattccc gttttgaagt ccgcacgaag ataagaaaac agattggtaa ttatgcagta
     9121 tagaagaaat tttactaata taaagtagag atggatccct atgttactag aattattatt
     9181 tcttgagata agaatattca tacagcgata atttagtagc cgtaggagct tttttaattc
     9241 tgaacgtaag cggatgataa aaaggattta ttcagaataa tcagtaataa aactcttacc
     9301 caagtcagta gctcgaatca agatgagttt tgtccttgat gaatattcgt tgtctgttaa
     9361 attttctaga aaatctcagt ttagatgttg gtatgccggc atttaatatt caaaaaatgt
     9421 gaaagattca gaaaatttga ttttttatta atcataatat tgggaatcat atttaacatc
     9481 gattgatagc aggagcaact aatggaagag cacagacgca tacgtacttg tctgttccat
     9541 ttgtttttta tatgattttg taaaagcagg tgtagggatt ataatttttt aaagtttgcc
     9601 gtttttcata acgtatacct ccataagatg tttcatgaat gagagctaaa cctagcaaag
     9661 aattgctttg ggtttttaat taatttaatg cgcaaccgta ttattactgg atttcggaat
     9721 atggcagcaa gtatctataa ttctgacatt tccataccta tttcaaatct attctgttca
     9781 ccccccccgg gttgctattt accctgctca aaaatcactc tgtttaaaaa tatatattgc
     9841 aaaatgaaat ataatcataa taaaatgaaa aaaatatttg acatttagaa agaaataata
     9901 tattataagt ccatagaagt tcgaatgatt agtaaaacac gaaatgaaat gttttgtgaa
     9961 gacgtgacaa aatataagta aaggaaagag gaaactgata atgaaagaca agttagttta
    10021 tgcagcgtct attcaagaaa gagcggacat attatcgttg tattataaag atacgaatgt
    10081 taaagacaat ttatcaaaat ggatgtcgag aaagtcgtta tgtacagagg agttattcga
    10141 tttatctcta caagaaaagc aaatggagcg caaaagtttt aatttggcta tcaaatcctt
    10201 agattccaat gatattgaag taatatcaaa agagattaaa agaatgatat ggtataaaaa
    10261 agcacacgag attcttgaag atgataaagc atattcaaca actcctgata taattgattt
    10321 ttcttatgca attagaccat ttttatacta tttaaaaaaa cagattgaac agattaaagc
    10381 tattggattt acaatttccg atgtggaagc cttttatata catttaggtc aagaattcat
    10441 acaaattgca gctaaaacat tagtctatga tttatatgaa caaaaaaaga aatttgcatt
    10501 caaaggaaaa acttccaatg atcgatttgt ttattatatg atcaagagat ttggtcagaa
    10561 aacatcattg atggagtttt atgaagacta tcctgtattg ctaagattac taacagaaag
    10621 ggtgctgttc catgctgata attttaaaga gtttattcga tcaataaaag aatccttacc
    10681 ggattttgaa aagacatttt ctttatcgaa gccatatcga ctatcaaata tttctgttgg
    10741 ggcaggagat agtcatggaa agggaaagtc ggttattttg tttgacttaa atgatcaacg
    10801 atttgcgttc aagtataaaa acttggaaat tggtgaaaga tttaatagtt ttttagaata
    10861 tatcgaaagg caaactggaa aagagttttt taaaataaag agaataataa aaaggaatta
    10921 ttgtatagaa gaatttgttc aaaggaaaga agtaaaatct gaagaagata tcagaaaatt
    10981 ttatcatcgt tttggcgaat atgttgcact tgcttattta ctttgtggaa atgattttca
    11041 ttacgaaaat ctaattgctc atggcgggtt tccggtattg atagatattg aaacattaat
    11101 tcaaaacgat agtccgatta aatatgctga taacccatac gtaagtttat cattaaaaaa
    11161 atttaattca gtattaggaa gtgctctttt accttttaaa gtatatggaa atcgaattga
    11221 accgatagct gaaggcggta gtaaaggaca aggaatacga ataagtgcat ttgatgggaa
    11281 aaaacagaag tctccataca aagggctaag tttgattaat gaaaatacag atgaagtcag
    11341 atttgattat gtggaatatg aactagaagg ggcaaataat attccggtat tcaatgggaa
    11401 agaggtggat gcagaaaaat ataagtatga agtggttgag gggtttaaag aaatatgcac
    11461 atatttttta aataataagt ataagcttat ttcagttgtg gagaatattt tttcaaatgt
    11521 tattgttcga aatgtaatta aaacgactca aaaatatgta gatatgctag gatacggcta
    11581 tcatcctaaa tgtatgatgg attatataga gagggagaag ttgtttgaaa acttatgggc
    11641 attcgaatat aaaaataaat cagcaatatt gtcagaaatc aaggatttat tggttaacga
    11701 tgtaccgata ttttttaata atacttcagc aaaggattta attacaagtg atggtaaagt
    11761 catcaaagaa tattatcttc aaacggcaat agaacatgtt aaaaatagaa ttattagttt
    11821 tagtaataat gaatacctat atcaaaagtt acgtttggag ttatccttag gtatttataa
    11881 acaagaaata gcaagattct acatggggga ttcagttagt acagcactag agaaaatcat
    11941 caatataatt cataatcgtg ctatatatga tgaaaagagt aatcaggttg catttgaaga
    12001 cttcatttat gaatcggatg gaacattaga ctataatgcg ttaaacgcag aattctatga
    12061 tggattgagt ggaatttata tatttgtttt atattatgca aaaagatatc cagacgaaaa
    12121 aattaaattg ctcaaatctg ctttggaaaa aagtctattt aaattaccca ataagaaggc
    12181 agaatatcat acattgagtg catatattgg aaaatattct ttactctatc ctttgtatca
    12241 taaatacaaa cttgaaggaa atgatgaaga tttgttactt gctgaaaatc taataaaaga
    12301 aattgaatat gagataggtg agaatgtaga agcagattgg ctaaatggtg tcagcggttt
    12361 aattcaggtt ctgatcaatt attataaatt gactaaaaaa actagctttt taaaaaaagc
    12421 tgaagtgtta tctacagttt ggaataaaaa agaaattaaa ttttgtggat ttgcacatgg
    12481 tttttctgga attatatatg cagcatattc tttatattgc gaaactggaa aagaaaatta
    12541 tagtaaacgt gttgaagaat atctatttct tgaggatcag tacattaaag gaaagatttg
    12601 gccggactta cgtgaaggga aaaatgcgac ttcacattgg tgtcatggta cgattggtat
    12661 cggtttgacg agattatatt tgttgaaaca tggatatcag aatgagcaag tttggaagga
    12721 ctttttgtat tgtttagaag atgctttatc tactaagtgt aaagaaactg gactttgtca
    12781 tggagagatg ggaagatttt tattcttgaa agaagcacag caattgaaat cagttccaaa
    12841 atctctccaa aataaaatag ataagtcctt gcgggagata cttcaagatg ttctagaaaa
    12901 tgggattgta attggggcat ttgaaaaaca gtgcatttta ggactgatga caggtattac
    12961 tggcattgga tatggattgc tgaaagaagc ggaaataaat attcccaata tcctatgttt
    13021 ggaataacaa ttatttggag gaggtgacag catttgagag gtgttacatc aatgtatttt
    13081 agatattagc taccttaggg tagcggtaag ataaaaaata aaaacaaata aatataacaa
    13141 ttagcaaaat tacaaggagg aactatgatg aaagacaaca aaaaagaatt aaatgtgata
    13201 acaggggtag catttgatga catgagcatt gatgaaatgg ctgaagtaca gggagccggg
    13261 gatgtcgagg gtgaagttac aacacctatt tgtgcagtgg cggttacagc cagtttgtca
    13321 attcaagttg caaagacact taaaggaaag tgttaaaata caactgaaat ttaacaatat
    13381 gataaagtga atctgtacat acttttttta aaattataga aacgaaaaag gagaaataga
    13441 catggcaaat gtaaatattg aaaatgtaat taagcatata gactttcaga aaattaaaga
    13501 ggaaaagaag aacggaaaaa gtcttgaaga gattcttaaa ggaattgatt tgaagccaat
    13561 tatccgagaa gaaatggtga aaatcaatcc agatgtgcag gatgaagaaa ttgaaagtgt
    13621 agttaaggaa attgatttga ttaaagtgct gggtagtatc cttgaaaatg agaatgtttc
    13681 aaaagaaatt gcaggtaaat tttttgaaga tttatcagag gaggaaatga ccatgctaca
    13741 gggagcagga gatgttgatg ttgaggttac accaaccatc acaacatcta gcacgccgtg
    13801 tatcggggct gtttcagcgg tgacaggtgg cattctttca tgggcaaagt gttaagggta
    13861 aagttcaact gaacttaagt aagaaaatgt acattatgaa tttagcggct gagttgatgt
    13921 aacaatgtga tacctaggat tcagccgcta tgcttagcaa atgcgtaagt aataaatagc
    13981 tatatttgaa tacctagaac cttgatggaa gggggaatat atagaaaatg aagaaaatcg
    14041 ttgctttatt tggaagcagg agaaaaaatg gaaatacagt ttcttttgtt aaagcaattt
    14101 taggctattt gccaaaagat gaatgtgata ttgaatatat ttttcctcaa gacttcaaaa
    14161 tttctccttg tatcggatgt ggaaactgtt ttgaacaaat acaatgtatt gcgaaagacg
    14221 agttatatat tttgcaaaaa aaaattttag attctgattt acttattgta gcttcaccgg
    14281 tttacttaca ctatatgtcg gcagatttaa aactaatttt agacaaatgt tcttggtgga
    14341 cacatactct tcggttacaa ggaaagccaa cagttgtctt gagtacttgt gattcaaatg
    14401 ggcatcgaac agtaatagaa ccattaagca aaataataac ttatatggga ggaaacgtga
    14461 tagcaacgtc aaacgctagt cagtatccag aacgcttaaa taataacact tggttaaatt
    14521 cagtatcaat tgagatatcg caaagaataa tcagatatct ttatttgcca ccacagtcta
    14581 atgtattttt agaggaatat tttttgcaac tgaaaaagaa tatgaagtta aaaagtcagt
    14641 tttttgatga aagaaaaata gaaaatgggg aggtgaatta ttggaaaaac tcgggtatgt
    14701 tggagtatga aaattttagt gattacttat tagatattgc aaaagttaaa gtcacaaaaa
    14761 aagagtgcat aaaacagttt taaacacaat gcagaatacc tagagatact gagagaaagg
    14821 aaaacccggt agtattaaca tttttggagg tatggaatta tggagaaaaa aacaaaaata
    14881 ttaagtatag taatacagat tgctttattt cttgctttta taggtttttt tttctcgtta
    14941 tttattggta atgagaaaaa tatttcaact tatacgaatt tgattttgat ttttgcttgt
    15001 tctaactatt ttttcttagc aagacagaag ttagaggatg cttatttgaa catttttgtc
    15061 aggatcaatg gagtgttgct agtactgtgg atagtcattg cggtgattca tttatttgtc
    15121 tagatgaaaa cagttactta aattatacaa gaaggttgat tcttcaggat tgtgaaggac
    15181 ttcaagatta ctatatcatt taaatcggaa aacaatcaaa ttattgtatg acatatatac
    15241 tatttgtagt gtttaattca tacaagttta ggtggttgtt ttctggttta aagtagttgc
    15301 tcgatatttg tgtgaagtat ataacataaa tcgtttacac agtatataca aaattatgaa
    15361 atgaatttag atataattat taaaaaaagt atgtgtggtt acggggataa aaaataagac
    15421 tgcaaaataa ttgatatgtt acaaaggtat tcaaagtttt gtatatgttc gtaaaactat
    15481 atatatgaaa tgctgttata agatgcggac aatataagcc atgttgtctg tattttcttt
    15541 tatcataaag tattaaaaat atctttagta gctcaattga aattagtaaa tgatgttgat
    15601 ttttagtgca accaaaagca gtgagaagta atattattct tccattttga aaaaaaacac
    15661 tttcaaaaat aaaagaattg tttacaatat aaaaaacaag tggtattata aaatggtata
    15721 ctgtctatgc agaagaaagg aggtaccaat ggcagtaaaa aaacatcata tagaagatac
    15781 tcaaatacat gtgtttcgtg ccaagaaaag aatgacgcaa caggaattgg ctgatcttac
    15841 gggggtttcg cgtcaaacaa taatgcagct tgagaaaaac aagtataatc cctccttatt
    15901 gttagcatat actatcgctg atgtgctaga cgctacaatt gatgatttgt ttattatttc
    15961 tacaaagtga ggtgaaaaga gtgttagagt tagttgaaaa aatttttgat aatattattg
    16021 ttttaaggat aaatggtata ttggggtttg tacttctttt cacttttgta tgttattttt
    16081 tctcaagaga aggaagagat gaaagaggta aaaagattat agctacagct gcacttacct
    16141 cattttttgc tttatttatt ttacttaata ttattccgat gtttctttcc tggctgatgg
    16201 aagattatac tcgactgttg aatggaatac agactatata tagtattttt cttttaatag
    16261 caaatgttac atggataatt ttaagaaaag tgagatgata aaataagatt gtagttagac
    16321 caaagattaa aggataatca tttaactgtc agaaatttaa taaaaagctc cctaaagtaa
    16381 agaataataa tgtttacttt aaggagcttt tttgtgtaga tcatctgtaa acgcaaaata
    16441 gcgagtgcat tgatgttcac gtttatctga agtataaagt atggaagtat ttcagattac
    16501 aaggaatgaa acttataatt cacctgcaga aaattagcat atgagggtct ggaacaaaag
    16561 ggagagaagt taaattcact cataagagga tagagaaatt acgttcagta tggaaactca
    16621 acaaaacgat ttaaatagct tgatgaatac gtgtggatga atctatggat acccactgag
    16681 ctttaaggtc catttgacga atgtaattcc ccacagtttt ttcggaaata cgctcccggg
    16741 atttccgcaa ttccgcagta attttagaag caccgtagtt ttgacgcgag tctttataaa
    16801 tcttttggat ttcttctttt aaaacggtat ggcgaataga cgtgtccgaa ggaacccgtt
    16861 tattccatat aactatctga tctcattgag ccgatggaat aacgctgtgg ttagatacca
    16921 atcatcgtaa gccatatcat agcttatgga tcacgtcatc agacgactgg cttccgataa
    16981 ctgattctat ggctctatct catgagattg agtggttctt aaaactcaaa gagtttcaga
    17041 ataatcataa ataacaactg actacaacag ttataaagga atttagaagc tcaatgacaa
    17101 aatgtgaaaa tgaatgcata aaaacatgaa aaattaaaga tagaaagtaa gtgcaaaata
    17161 attcgacgga ttgtgttgcc ctaaaaaata tcccataata atcaatagag aatgcaagca
    17221 tt
//
