GCF_015555015.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JADNJR010000016.1 (Dorea longicatena)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	cyclic-lactone-autoinducer,lanthipeptide-class-i	51,186	82,834	High	nisin O	ribosomal:RiPP:Lanthipeptide

NZ_JADNJR010000017.1 (Dorea longicatena)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	ranthipeptide	36,688	58,438

NZ_JADNJR010000023.1 (Dorea longicatena)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	ranthipeptide	3,782	28,577

NZ_JADNJR010000007.1 (Dorea longicatena)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 46.1	terpene-precursor	37,604	58,506

No secondary metabolite regions were found in these records:: NZ_JADNJR010000010.1 (Dorea longicatena); NZ_JADNJR010000011.1 (Dorea longicatena); NZ_JADNJR010000012.1 (Dorea longicatena); NZ_JADNJR010000013.1 (Dorea longicatena); NZ_JADNJR010000014.1 (Dorea longicatena); NZ_JADNJR010000015.1 (Dorea longicatena); NZ_JADNJR010000018.1 (Dorea longicatena); NZ_JADNJR010000019.1 (Dorea longicatena); NZ_JADNJR010000001.1 (Dorea longicatena); NZ_JADNJR010000020.1 (Dorea longicatena); NZ_JADNJR010000021.1 (Dorea longicatena); NZ_JADNJR010000022.1 (Dorea longicatena); NZ_JADNJR010000024.1 (Dorea longicatena); NZ_JADNJR010000025.1 (Dorea longicatena); NZ_JADNJR010000026.1 (Dorea longicatena); NZ_JADNJR010000027.1 (Dorea longicatena); NZ_JADNJR010000028.1 (Dorea longicatena); NZ_JADNJR010000029.1 (Dorea longicatena); NZ_JADNJR010000002.1 (Dorea longicatena); NZ_JADNJR010000030.1 (Dorea longicatena); NZ_JADNJR010000031.1 (Dorea longicatena); NZ_JADNJR010000032.1 (Dorea longicatena); NZ_JADNJR010000033.1 (Dorea longicatena); NZ_JADNJR010000034.1 (Dorea longicatena); NZ_JADNJR010000035.1 (Dorea longicatena); NZ_JADNJR010000036.1 (Dorea longicatena); NZ_JADNJR010000037.1 (Dorea longicatena); NZ_JADNJR010000038.1 (Dorea longicatena); NZ_JADNJR010000039.1 (Dorea longicatena); NZ_JADNJR010000003.1 (Dorea longicatena); NZ_JADNJR010000040.1 (Dorea longicatena); NZ_JADNJR010000041.1 (Dorea longicatena); NZ_JADNJR010000042.1 (Dorea longicatena); NZ_JADNJR010000043.1 (Dorea longicatena); NZ_JADNJR010000044.1 (Dorea longicatena); NZ_JADNJR010000045.1 (Dorea longicatena); NZ_JADNJR010000046.1 (Dorea longicatena); NZ_JADNJR010000047.1 (Dorea longicatena); NZ_JADNJR010000048.1 (Dorea longicatena); NZ_JADNJR010000004.1 (Dorea longicatena); NZ_JADNJR010000005.1 (Dorea longicatena); NZ_JADNJR010000006.1 (Dorea longicatena); NZ_JADNJR010000008.1 (Dorea longicatena); NZ_JADNJR010000009.1 (Dorea longicatena)

Compact view

NZ_JADNJR010000016.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-i

Download region GenBank file

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Location: 51,186 - 82,834 nt. (total: 31,649 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

I2E58_RS10840: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

I2E58_RS10850: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001701.4	0.68	ribosomal	nisin O	Blautia obeum
BGC0000538.3	0.47	ribosomal	nisin Z	Lactococcus lactis
BGC0002576.2	0.43	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.43	ribosomal	penisin	Paenibacillus ehimensis
BGC0000506.4	0.40	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.36	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000541.5	0.36	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.36	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000535.4	0.33	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000515.4	0.33	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001701.4	0.83	ribosomal	nisin O	Blautia obeum
BGC0002576.2	0.74	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0000538.3	0.65	ribosomal	nisin Z	Lactococcus lactis
BGC0001289.5	0.59	ribosomal	penisin	Paenibacillus ehimensis
BGC0000541.5	0.56	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.56	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000535.4	0.56	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000515.4	0.55	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002323.2	0.54	ribosomal	nisin J	Staphylococcus capitis
BGC0000506.4	0.52	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for I2E58_RS10850

I2E58_RS10875

Leader:

MAKFDDFDLDVTKTAAQGGIEPK

I2E58_RS10880

Leader:

MGKFDDFDLDVTKTAAQGGIEPK

Shared core:

YKSKSACTPGCPTGILMTCPLKTATCGCHITGK

Core with dehydrations:

YKDhaKDhaACysDhbPGCysPDhbGILMDhbCysPLKDhbADhbCysGCysHIDhbGK

antiSMASH-DB 4.0 matches for I2E58_RS10875

100.0%

NZ_JADNJR010000016.1and 2 others:

NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptideNZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide

Lanthipeptides: I2E58_RS10880_lanthipeptide

YKSKSACTPGCPTGILMTCPLKTATCGCHITGK

97.0%

NZ_QSHK01000002.1and 1 other:

NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide

Lanthipeptides: DW860_RS04735_lanthipeptide

YKSKSACTPGCPTGILMTCPLKTATCGCHITGK

YKSKS CTPGCPTGILMTCPLKTATCGCHITGK

YKSKSVCTPGCPTGILMTCPLKTATCGCHITGK

78.8%

NZ_CP015405.2and 7 others:

NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptideNZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptideNZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide

Lanthipeptides: A4V09_RS08300_lanthipeptide

SKSACTPGCPTGILMTCPLKTATCGCHITGK

SKS CTPGC TGILMTCP++TATCGC ITGK

SKSLCTPGCVTGILMTCPVQTATCGCQITGK

with 71 more sequence matches

Only the first 10 are displayed here.

69.7%

NC_015600.1and 14 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

SKSACTPGCPTGILMTCPLKTATCGCHI

SKS CTPGC TGILMTC +KTATCGCH

SKSLCTPGCKTGILMTCAIKTATCGCHF

69.7%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

SKSACTPGCPTGILMTCPLKTATCGCHI

SKS CTPGC TG LMTCP+KTATCGCH

SKSLCTPGCKTGALMTCPIKTATCGCHF

69.7%

NZ_JAMDIB010000004.1:

Lanthipeptides: M5P35_RS04030_lanthipeptide

SKSACTP-GCPTGILMTCPLKTATCGCHI

SKS CTP GC TGILMTC +KTATCGCH

SKSLCTPPGCKTGILMTCAIKTATCGCHF

66.7%

NZ_CP024974.1and 1 other:

NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide

Lanthipeptides: CVO91_RS06555_lanthipeptide

SKSACTPGCPTGILMTCPLKTATCGCHI

S S CTPGC TGILMTC +KTATCGCH

SISLCTPGCKTGILMTCAIKTATCGCHF

63.6%

NZ_BMMB01000002.1:

Lanthipeptides: IEX62_RS05935_lanthipeptide

YKSKSACTPGCPTGILMTCPLKTATCGCHIT

+KSKS CTPGC TG+L TC ++TATC CHI+

WKSKSFCTPGCVTGVLQTCFIQTATCNCHIS

60.6%

NZ_CP025079.1and 3 others:

NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptideNZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptideNZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide

Lanthipeptides: BVQ_RS17705_lanthipeptide

YKSKSACTPGCPTGILMTCPLKTATCGCHIT

+KS+S CTPGC TG+L TC L+T TC CHI+

WKSESVCTPGCVTGVLQTCFLQTITCNCHIS

60.6%

NZ_CP117416.1and 1 other:

NZ_JAQQZQ010000001.1 Lanthipeptides: PO903_RS06885_lanthipeptide

Lanthipeptides: PQ456_RS01230_lanthipeptide

YKSKSACTPGCPTGILMTCPLKTATCGCHIT

+KS+S CTPGC TG+L TC ++TATC CHI+

WKSQSFCTPGCVTGVLQTCFIQTATCNCHIS

60.0%

NZ_NHVL01000013.1:

Lanthipeptides: CEU70_RS16830_lanthipeptide

SKSACTPGCPTGILMTCPLKTATCGC--HITGK

SKS CTPGC TGIL TC +K+ATCGC HI GK

SKSLCTPGCKTGILQTCAIKSATCGCSIHIGGK

58.8%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

SKSACTPGCPTGILMTCPLKTATCGCHI

S S CTPGC TG+LM C LKTATC C I

SYSLCTPGCKTGVLMACHLKTATCNCSI

58.3%

NZ_NHVL01000013.1:

Lanthipeptides: CEU70_RS16825_lanthipeptide

SKSACTPGCPTGILMTCPLKTATCGCHI

SKS CTPGC TGIL TC +K+ATCGC I

SKSLCTPGCKTGILQTCAIKSATCGCSI

MIBiG 4.0 matches for I2E58_RS10875

55.9%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

SKSACTPGCPTGILMTCPLKTATCGCHI

S S CTPGC TG LM C +KTATC C I

SISLCTPGCKTGALMGCNMKTATCHCSI

12.1%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPGCPT

TP PT

TPATPT

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.05 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.15 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (5):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.77 out of 23.43

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.81 out of 18.46

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.50 out of 26.12

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.64 out of 30.25

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.70 out of 27.18

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

I2E58_RS10875 - Class I

Cleavage pHMM score: 12.50

RODEO score: 26

Monoisotopic mass: 3226.6 Da

Molecular weight: 3228.9 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3246.9 Da N = 1; 3264.9 Da N = 2; 3282.9 Da N = 3

I2E58_RS10880 - Class I

Cleavage pHMM score: 12.50

RODEO score: 26

Monoisotopic mass: 3226.6 Da

Molecular weight: 3228.9 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3246.9 Da N = 1; 3264.9 Da N = 2; 3282.9 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 142 - 228; Score: 44.3

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_JADNJR010000017.1 - Region 1 - ranthipeptide

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Location: 36,688 - 58,438 nt. (total: 21,751 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

I2E58_RS11145: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

I2E58_RS11220: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Translocases: transport

I2E58_RS11200: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001387.5	0.35	other (other)	nucleocidin	Streptomyces calvus
BGC0000842.5	0.34	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0001607.5	0.32	other (other)	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0001591.4	0.31	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000604.4	0.30	ribosomal	GE2270A	Nonomuraea sp. WU8817
BGC0001155.5	0.30	ribosomal	GE2270	Planobispora rosea
BGC0001540.5	0.30	other (other)	CC-1065	Streptomyces zelensis
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000466.5	0.27	NRPS	yatakemycin	Streptomyces sp. TP-A2060

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001387.5	0.35	other (other)	nucleocidin	Streptomyces calvus
BGC0000842.5	0.34	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0001607.5	0.32	other (other)	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0001591.4	0.31	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000604.4	0.30	ribosomal	GE2270A	Nonomuraea sp. WU8817
BGC0001155.5	0.30	ribosomal	GE2270	Planobispora rosea
BGC0001540.5	0.30	other (other)	CC-1065	Streptomyces zelensis
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000466.5	0.27	NRPS	yatakemycin	Streptomyces sp. TP-A2060

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

Additional weak hits (3):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.79 out of 19.52

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.82 out of 30.12

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.50 out of 32.93

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 0 - 111; Score: 96.0

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_JADNJR010000023.1 - Region 1 - ranthipeptide

Download region GenBank file

Download region SVG

Location: 3,782 - 28,577 nt. (total: 24,796 nt) Show pHMM detection rules used

Region on contig edge.

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002825.2	0.42	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000802.5	0.42	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0002144.3	0.40	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0000518.3	0.40	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000594.5	0.39	ribosomal	microviridin K	Planktothrix agardhii NIVA-CYA 126/8

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002825.2	0.42	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000802.5	0.42	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0002144.3	0.40	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0000518.3	0.40	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000594.5	0.39	ribosomal	microviridin K	Planktothrix agardhii NIVA-CYA 126/8

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.19 out of 21.55

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.24 out of 23.79

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.59 out of 33.14

Confidence: medium

Additional weak hits (5):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.78 out of 30.22

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.30 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.81 out of 26.06

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 34 - 87; Score: 35.4

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
IolR	Regulator of the inositol catabolism
ZuR variant 2	Zinc-responsive repressor

NZ_JADNJR010000007.1 - Region 1 - terpene-precursor

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Location: 37,604 - 58,506 nt. (total: 20,903 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase

I2E58_RS06020: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: back translocase

I2E58_RS06085: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase

I2E58_RS06055: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

I2E58_RS06060: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.38	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000663.5	0.38	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.38	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000663.5	0.38	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

I2E58_RS06060: PT_FPPS_like

Domain 1 (35 - 298): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

Additional weak hits (2):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.23 out of 20.01

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis