LOCUS       NZ_JADNJR010000023     24796 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Dorea longicatena strain 1001136B_160425_G1
            NODE_23_length_53714_cov_67.9729, whole genome shotgun sequence.
ACCESSION   NZ_JADNJR010000023
VERSION     NZ_JADNJR010000023.1
KEYWORDS    WGS; RefSeq.
SOURCE      Dorea longicatena
  ORGANISM  Dorea longicatena
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Dorea.
REFERENCE   1  (bases 1 to 53714)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 53714)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.58x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 03:07:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,053
            CDSs (total)                      :: 2,995
            Genes (coding)                    :: 2,936
            CDSs (with protein)               :: 2,936
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 10 of 59
            Pseudo Genes (incomplete)         :: 53 of 59
            Pseudo Genes (internal stop)      :: 5 of 59
            Pseudo Genes (multiple problems)  :: 7 of 59
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:58:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3781
            Orig. end                         :: 28577
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADNJR010000023.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24796
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..24796
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24796
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:14796](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14796
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    500..515
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.78"
                     /tool="antismash"
     gene            538..1641
                     /locus_tag="I2E58_RS12835"
     CDS             538..1641
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="ATP-binding protein"
                     /protein_id="WP_055195773.1"
                     /transl_table=11
                     /translation="MIIMDIKVDNIYAFKDFHINMSYPKKIVNSTIENEFLEERTNFRY
                     KKVNIIMGTNATGKTTMGKLLMLFTNYLNDGGYKRFTNRIADVKKAAKLQIDFVTNENL
                     LYRFEMNVGPKTQKSYTEEDVDIKIFYTPIETRDSYETCASRLDMYECEETTYEKVNTN
                     GWKFSYPIDSSGDKVYSTIEENSKYIYILQQILKTLDSSVEEVVKVSEVENTYVIKWKN
                     CSAIIKDGKIANGEVMSSGTKAGLEISYIITSLLCDMHDLYYCDELFSYVNSDIEKACL
                     SIIIEKLSGRKQLFFTTHNSDILDMQLPKHSFTFLKKDVNNEDDSIKCIAASQYLKRST
                     DSLKHAVENDLFCTAPELHRLFEIADL"
     gene            1657..2178
                     /locus_tag="I2E58_RS12840"
     CDS             1657..2178
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS12840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_195465094.1"
                     /transl_table=11
                     /translation="MRKSGIYQYYVEGEDERSLLNTLKLDLRCIESGKIDKFNVIQSRF
                     TTARMRTLKTGTTVVLVYDTDVEMNTKILDENIAFLKRQKGIKEVICIPQVRNLEDELV
                     RACNIKNIVDLTKSLTKADYKKDLINCSNLSDRLKKCKFDITKIWAEIPKNNFKKYGND
                     SEKIKIKSKK"
     misc_feature    2319..2336
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.19"
                     /tool="antismash"
     misc_feature    2343..2355
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            2425..3696
                     /locus_tag="I2E58_RS12845"
     CDS             2425..3696
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="I2E58_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_195465095.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 2.1e-52, bitscore:
                     169.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHTQQLFLEALKAALKNEQVEWNNKLEAQEWMDLFRMAEVHQIL
                     PMIYEAVYRSPAAGQADPQILAPAKAQMVRTVIMQTQKTGEFEPLYRYLRESGICPLVV
                     KGIVCRNIYPNPDYRISGDEDLLIRPEDFRKCHDLLREYGMQTSEQDMDAEELESVYEV
                     PYGKKGSLIYIELHKSLFPPESEAYGDLNRFFANVHEDAIDIRIDGTDIRTMGYTDHLF
                     YLICHSFKHFLHSGFGIRQVCDIILFANEYGDAIDWEKILRQCCEIHADLFAAALFAIG
                     EKYLTFDPGKAHYPKAWRKISVDETDMLMDLLDSGIYGNANMSRKHSSNMTLDAVAADK
                     NGKKAGNTVLKSLFPSAKKLEGRYPYLKKHPILLPIAWTDRILKYRKETVAGGDNAAAD
                     SVKIGNQRIELMKEYGIIKNDIKR"
     gene            3786..6479
                     /locus_tag="I2E58_RS12850"
     CDS             3786..6479
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427204.1"
                     /locus_tag="I2E58_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_195465098.1"
                     /transl_table=11
                     /translation="MKRKKSTQLLAVALTAAMLAQPVGAQMVFAEGNADAVQQEQAVSP
                     AAETTEAVLKSGTAVIPADADLNQVKAILGKTLVENADQVDLNSLEWEYKCEGKTGLTG
                     LEVSGNESWGSIGGFTSSKKGIFGTTTTYTHPSLATNKDATYPVRLKGTTTEVTLKKTQ
                     KLTSAILIKDNTNVNLVYNEDGSINYNAVRQNIFNTVVESTTPELTANDVTIEYYATAT
                     TGAAVGFGKEWMPLEGGKSGTPIALTYPAMGDGTQKIKISYAGTDAYSGASAEATVNIG
                     IGREQSVIAFKENPTIKLVYNDDLTVDYAAAKEAIMNDVIDVENSSPEGLSLDNLTIEY
                     YATGALGSLVKAWAPIEGGKINGLTYPGIPEGTQKIRVTYAGDKENTAVTAETDIKVID
                     REQSAFNLNEPAEGAASYEVPMAFNEDQTYDYDATAKAIYNAVVASTVPENLTADDVTI
                     RYNAGTDMLKNWQPLNTTDWTSTFTKFGPGEWTIQFSWAGNKEYKGATTEVKVNVTDNR
                     LASALVCKEGVSFTYNMDAAVMKQAIFDNVIDWENSTLPAKDTLTVDNFTMEYYGSNTL
                     AGDIDGGVKQWAPIEGGTVTFLTYARMGAGEQKIRITYKGNAQYRPSAQTESTVTVNKA
                     KVKVKVKSTSIYAGATLPEDFVTMNPADKFDVYTVYGGLTSNANLSLYLDLPDKYTNSA
                     VLKLLDPIVEKLYGKTFTQMMNDGMTVGELRQLLSTQELLDLLEKLHIDTGTFGQILTI
                     INKMPSVADSVRVSFGTPNHAGLYTVTAVTDSKNYETGVGIGTLLVKMRSKGVKLNWNE
                     RFVNGKITAEEAKNFDFKATLSADGAVTIAQDNVHYLYSGFTSKWKIYSSTTTPPTEPG
                     SYVMTVVTLGGDYQAAPIKRGFKITK"
     gene            6977..7912
                     /locus_tag="I2E58_RS12855"
     CDS             6977..7912
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012376.4"
                     /locus_tag="I2E58_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="WP_006427206.1"
                     /transl_table=11
                     /translation="MKETGESGSTKNKTVILLLIILLTLLWFVGEILVSYHWMKVNRYP
                     VQVRNLRYADTVTDAGFKMVVISDLHDHEFGKDNEKLIRCVKEQDPEMIILDGDMLNED
                     SKSDEVPVRLVKGLAEIAPVYYALGNHELDYIGTAEGKKMQKHPENSELVKDLTDAGAC
                     VLEEGYRDVEIGGCKVRIGGMYEYAFALDGDNSAENLTGNVRDFLEEFQNTDRYKIMLC
                     HRPDSFVFGDASDYWKIDLVISGHDHGGQVVIPFKGGLYGGDQGWFPPYVHGLYRTGRI
                     RLFVTSGLSSEKQKLPRWNNRPEIAVLNVH"
     gene            7966..8298
                     /locus_tag="I2E58_RS12860"
     CDS             7966..8298
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_044919822.1"
                     /transl_table=11
                     /translation="MSSKITADSVLDGDLTSNIKYSLEKTVNTQAAGEYPIEFRVMDRG
                     GNTVYLKTQISISDKSYAGIDVKLKDYLIYLSVGDAFDPNAYFDSADKEGELTVQSNVN
                     TAKAGS"
     gene            complement(8378..9097)
                     /locus_tag="I2E58_RS12865"
     CDS             complement(8378..9097)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="I2E58_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_195465100.1"
                     /transl_table=11
                     /translation="MNIAICDRYDTDITRISEFLDANIKNHMLNHALLEVDTFTSTDEL
                     LASPKEYSLIFLGILMPGTDGIETARQLKDGPNPPIIIFTTKRTEHCLASYNLGVEGYI
                     LKPIREEDFEKVFTRLLLPIFPSTHTLNVYSNWLLYHIPVSEIFYIESIGRKCMIHTSR
                     KTYETNMALNHIESTLNDNSFIRCYRSYLVNMNYIQDILDTEIQLTNDDCIPLTLRKRS
                     QIVKLFNKFLISHSASE"
     misc_feature    complement(9078..9090)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     misc_feature    9164..9180
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: medium, score: 26.59"
                     /tool="antismash"
     gene            9497..9937
                     /locus_tag="I2E58_RS12870"
     CDS             9497..9937
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427210.1"
                     /locus_tag="I2E58_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S24/S26 family peptidase"
                     /protein_id="WP_055303328.1"
                     /transl_table=11
                     /translation="MKVVDTREYVGMLKELTEEGKEVSMLVFGSSMAPFLIHARDMIYF
                     KKPDRELQKGDIVFFRRKSGQFVMHRIWKIRPEGYYIVGDAQTQIEGPVKREQIFALIT
                     KVRRKEKWLEPGDFWWEFFEHVWLHMIPLRRGIMWCYAKVIR"
     gene            10001..10288
                     /locus_tag="I2E58_RS12875"
     CDS             10001..10288
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427212.1"
                     /locus_tag="I2E58_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_055194344.1"
                     /sec_met_domain="PF05402 (E-value: 1.9e-18, bitscore: 58.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.2e-11,
                     bitscore: 35.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVKEFILREIAGECVLVPTGATSQEFNGMITISDTAKFIWENI
                     EKVDSLEEMIRMVLDTYEIDEETARRDTIAFVGALVENGFIECTREDGTW"
     aSDomain        10103..10261
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I2E58_RS12875_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.30E-11"
                     /identifier="RREFam002.1"
                     /label="I2E58_RS12875"
                     /locus_tag="I2E58_RS12875"
                     /protein_end="87"
                     /protein_start="34"
                     /score="35.4"
                     /tool="antismash"
                     /translation="SDTAKFIWENIEKVDSLEEMIRMVLDTYEIDEETARRDTIAFVGA
                     LVENGFIE"
     gene            10282..11196
                     /locus_tag="I2E58_RS12880"
     CDS             10282..11196
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_055303323.1"
                     /transl_table=11
                     /translation="MVEQNESITRLYRIGHTEIEITAPLSMKSPRNLEKFRIGQAKRPD
                     DEVIHYQVEMTENLDEIKEDLLGKKTGRVIYRDNLTVFQTSGGECRFINFLGMDWHYAV
                     SSQEGVNQYHVWFVPEVAEMLDQDTVYLAAFSLEKQAIKDHSMILHSAYMCYEDTAVLF
                     SAPSETGKSTQAGLWEKYRGTWTVNGDRSLLIREEDGWYANGWPVCGSSEICNNKSYPV
                     RAIVMLSQAKENRISRLKGLEALRKVMEQITINAWNSEFQIQAMDELEILLKEVPVYHL
                     ECDISEDAVRCLEDVLAGGRGEE"
     gene            11197..12993
                     /locus_tag="I2E58_RS12885"
     CDS             11197..12993
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427214.1"
                     /locus_tag="I2E58_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_055303321.1"
                     /transl_table=11
                     /translation="MQENNDKNQGKNGLSFESLDILIAKWKDGTFSEIIDDWKWIFSYS
                     VRYKWAIVFYTILGIFSTSMGLVSSVAGKYLIDIITGYKTNKLMILIIVMVGSSLFSLL
                     FSSIISRISTKLSIYINNDIQADIFDKIVDADWLEINKYSNGDVLNRFNGDIGTVSSNA
                     ISWLPTIVIAIYNFIATFLVILHYNAVMAILALASAPFMLLMSRFMIKKQREYSQKTRE
                     MSSKLMTFEVEAFYNFDTIKSFGIAPHYSRLMRWWQGKFKDVSLEYNMFSIKTNILLSV
                     MGTGVEFIAFGYCLFLLWTHTITYGTMTLFLQQRSNLSGAFNNVVSIIPSFLNSSVSAH
                     RIRELVELPKEVHISESEELDPFAEDGFEVLMKDVNFAYVEGTRVITDSYFKACPGEIV
                     ALVGPSGEGKTTMIRLILGLIRPQEGEAVIVASNGREIVLNAETRHFFAYVPQGNTILS
                     GTIAENMRMVKEDATDEEIIEALKIACAWEFVEKLPDTINSALGERGRGLSEGQAQRIS
                     IARAVLRNAPILLLDEATSALDVTTERKVLRNIIEQKPNKTCIVTTHRPSVLNMCQRVY
                     RVMETKVTELDEEESSRMAIDF"
     misc_feature    13021..13034
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            13239..13607
                     /locus_tag="I2E58_RS12890"
     CDS             13239..13607
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008394245.1"
                     /locus_tag="I2E58_RS12890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_195465102.1"
                     /transl_table=11
                     /translation="MKRAYVRPTMVGERFVANEYVAACGDKEKVYKFRCDAGGGKSGEV
                     YLETNNIKGFQPLGDTYLSSYHACGITHDASTADKFLDGYYVRGLKVTPVKVWRGEKGD
                     NTHCTTKINIKEWETAKS"
     misc_feature    complement(13651..13664)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.81"
                     /tool="antismash"
     gene            13690..14796
                     /locus_tag="I2E58_RS12895"
     CDS             13690..14796
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427216.1"
                     /locus_tag="I2E58_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_055213867.1"
                     /sec_met_domain="PTHR43273 (E-value: 9.8e-38, bitscore:
                     121.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.5e-27, bitscore: 87.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.4e-11, bitscore: 35.9,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-08, bitscore: 26.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.3e-10, bitscore:
                     31.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELMEDGTTIEQQMFAMATEKKVPLYGVLELLPLCNLNCDMCYVR
                     MSREEMEEVGRLRTMEEWTKTAEDMMRAGTLFVLLTGGEPLLYPHFRELYQKLRELGMI
                     ITINTNGTLIDEAWADFFAENKPRRINITLYGASNETYERLCHYPGGFDKAVNGIRLLR
                     ERNIDVKVNGSLAKANVDDRMKIIELGESLDAPVRIDTYMYPSVRERNHAYNNQARLDP
                     EMAAKARVEVLRREMGEEVFAQYRKIQLDEAENTPEGEAVPGQMTCRAGKSSFVVNWQG
                     EMRSCVVLDKPSIPLRDVEFEEAWKFTKKETESLRISARCSSCKLRKVCNTCVAAAIAE
                     TGKADGVPEYLCRYTEATVRYLKETSKK"
     gene            14883..15650
                     /locus_tag="I2E58_RS12900"
     CDS             14883..15650
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030145 - manganese ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039343.3"
                     /locus_tag="I2E58_RS12900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CpsB/CapC family capsule biosynthesis tyrosine
                     phosphatase"
                     /protein_id="WP_055213868.1"
                     /transl_table=11
                     /translation="MIDIHAHILPGIDDGAEDMYDTLEMARMAADSGVDKIIATPHCNI
                     PGMYGNYFGKEYIDRYESVVRAVRKEKIPIEILPGMEVFSTEDLPELIVNHKIMPLNQS
                     RYILMEFAFDEDPEFADSILKRVEEVGARPVIAHAERYEFIQDYPQIAYRWFRKGYVIQ
                     ANKGSFLGRFGGGPKRAADSLLRHNLISVIASDAHSPLQRTPYMLDAYEELSREYSENH
                     LDVLFQYNPARICDNREILRLEPVPYSGRQQLY"
     gene            15669..16577
                     /locus_tag="I2E58_RS12905"
     CDS             15669..16577
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014544.4"
                     /locus_tag="I2E58_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="immunoglobulin-like domain-containing protein"
                     /protein_id="WP_173734368.1"
                     /transl_table=11
                     /translation="MRRLKIAVCLIFVASCVIFAGYTVKSKMLEDHTPPVINCKDKTVT
                     LSVQTDQKKQKKALLKGVKAEDNRDGDLTSSVRIASMSHFIAPGKRTITYVVFDKANQV
                     GTLERTVQYKDYTPPKIHLKAPLRYSTTEVGKANLTENMKAEDCLDGDLTSQIRTSLDD
                     GMYNAAAGIYKVTVQVSNSAGDVCSVPLEVTVTESGDRQEQMKEYPVLSDYIAYTTVGH
                     EIDPMSYVKGMEMNGATYTYADDGEALAGTREAISVKSEVDYSKAGVYPVEYFYTAEGA
                     PTAVTKLFVVVQDQEGAQDGE"
     gene            16567..18015
                     /locus_tag="I2E58_RS12910"
     CDS             16567..18015
                     /EC_number="2.7.10.2"
                     /GO_process="GO:0045226 - extracellular polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01007.1"
                     /locus_tag="I2E58_RS12910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide biosynthesis tyrosine autokinase"
                     /protein_id="WP_195465104.1"
                     /transl_table=11
                     /translation="MESSNRNDMPVFMDNDLDPYTLVHDIVSNWWVIILGAIAGALLTY
                     VVVSSRYVPEYTTQATFVVSSRGDANAYSNLSSANTMAKTFEKILKSNIMEKKICEKLK
                     VEELDADIHAKVLEGTNMLVLSVTADTPKESIDIIRTVMDNYSSVSLYTVGSAVMDVLE
                     EPKIPYTPDNPLDAGRQAKKGGLVAGALVLILLGMFSYMKNTIKQENEIEKKLDARSLG
                     AISYEWKYKTIRDIFRRKKKAILVDDPVASFRFVESYKKLAAKVEYRMAKNEQKVLVVT
                     SVSENEGKSTVAANLAITLAEQSKRVLLVDGDIRRPSQFLIFGMEPKEENELGEYLKGN
                     RALADVMVPCTRKHMLFMGGKNCYSSSTEMLNSESFFKLMTACRKFVDYVIIDTPPAGI
                     IGDAQIFAHCADAVMIVSRQNYMLAEDINEVMDAFRDKEGKVLGVVLNGVRSFSGLVDS
                     PVGHYYGKYSKYGRYGNYGRSKGM"
     gene            18021..19559
                     /locus_tag="I2E58_RS12915"
     CDS             18021..19559
                     /GO_process="GO:0045226 - extracellular polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01007.1"
                     /locus_tag="I2E58_RS12915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide biosynthesis tyrosine autokinase"
                     /protein_id="WP_195465106.1"
                     /transl_table=11
                     /translation="MGDYRDKSGSERVDAPEKIDLTNVMLDVYHGVKRLWWLFIGLIII
                     CAVQSYFSVSTSYQSKYVASATVSVTSVGGMDYVDAQSAQQMAEVFPYILTSGVLKDVV
                     AEDMGLDSMPGSIDVKADDGTNLLTISVSGNDPQMAYKTLKSVIKNYPKVAEFVLGETK
                     LTILDETGIPTDTKRVEVIRGSYKRGALKGAIIGCVILLLYVLSRRTVKSRKDLKKNIN
                     LQDLGSIPYVRTKKRKKETFYNSVSLLNERISMSYLEAIRKLRIRVMKDVEKKEYQTLL
                     VTSSIPGEGKTTLSANLAISIAQQGKKVLLVDCDLRNPSIAGVMNEQEPHPGLGSVLKK
                     EVPLSEAITNVKLPKERTNENGSLHVIFGGAPDGENSLLIGSGRMRALIEALKSKYDII
                     ILDTAPSELLADAPLLGKYVDAALYVIRYDYTKLREIREGVESLALSGIDMLGYVFNGD
                     NSSGGQGYGYGYRRYGNYGSYGSHYGSYGKYGAYGHYGKMEKGSTDKFGRVIKD"
     gene            19574..20512
                     /locus_tag="I2E58_RS12920"
     CDS             19574..20512
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00350.1"
                     /locus_tag="I2E58_RS12920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LCP family protein"
                     /protein_id="WP_195465107.1"
                     /transl_table=11
                     /translation="MKFFRKHKKRKIAGIIILLIVLLIGGIYGSIWWKFYGDSVGVVSA
                     DKVDPKAKKVKIAKEKRKDKDVYNVLLVGTDSRDPDADRGRSDSMMMVSFNKKEGKSTA
                     ISFLRDSLVDIDGHGKSRLGHTYAYGGVGLTINTINKTYDLDIQNYITISFDDLVNVID
                     EIGGVTVFISEEEAAYYRENGMPDIQAGDVTLTGSQALAHVRNRTLGNDFERTRRQRSV
                     MYGIYRKIMEKKDPSALLPLINYAVNHVRTNMSVSEMYSMAKDVLSVDDLKMQQTCIPQ
                     DGTYTDITYEGMQVLKVDFDANKKKIEQLLY"
     gene            20562..22172
                     /locus_tag="I2E58_RS12925"
     CDS             20562..22172
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427222.1"
                     /locus_tag="I2E58_RS12925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_195465109.1"
                     /transl_table=11
                     /translation="MKQSKKVVARIIILILALFTVIPGTVSQKVYAEPGGSESSQAADA
                     SKDDSNKKEEKKEEDMTPEEREKKAEEDAYKMEIQSNGWKNWPKGPGTYGEAAIVMDAG
                     TGSILYAKNIDEHEYPASITKVLTSLIALKYGNLSDKVTFSNDCISFMQPGDSSVGLKE
                     GNVISLEQALYATLLASANEAAYAVAENVGKNAGYDYNWFIQQMNEECKSLGGNNSNFV
                     NANGLHDDNHYTCARDMALIGREIWRYPEFLKICQEQSYKIPASDTTEEHVFPQHHKML
                     IKENKNYYQYAVAGKTGYTSNALSTLITLADNGNMKLVCVVLRTHGVNIYPDTKNLFEY
                     AFNNFQKIQVADEKKPDEVEKFISAADSQSAVSAQSDGSEDTESVQTGGNEYQPLEDGH
                     VILPKDVSYKDIDYEITDVDEDTGEGTIRYIYDGHQVGSATAKFTDKYLQKVSTRKERV
                     DSKPKDVDNSGDSKKNGGKSSEKSIWKNFLQKVKAVWDFGQKKFAGKSSTEKYMIAGGC
                     VALVILIFSLIVLLIRRRR"
     misc_feature    complement(24528..24542)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.24"
                     /tool="antismash"
ORIGIN
        1 tctgaaatct gtaacctatg acggaaggaa gagaaagacc tggacgaagg attcggtaaa
       61 gcaatttgcc gtaatcggtg gatatgtgat ctgctgtacg gaggatgaga agcttatccg
      121 ttgtgatatg tcgacgggca agagaaagga actggcggat catattcagt acttttttgc
      181 cggcgcgaag ctgtatgcgc agaaggggtc gaagattgtg tcggtcagct atgacggcaa
      241 agaggtcagg gtatttaaga aagatgtggt tatgatggat aagaaggaag acaaggtata
      301 ttataggaga atggacagga agaaagagca gatgtatgtg tgtgatgtgg atggtgggat
      361 ggagaagatg gttggaagcc gagattaatt gtctttaatt tatatatccg tgttctaata
      421 tattttatgc aagaatatat ttagaataag cttgaaattt atcgtaaaag gggtatataa
      481 taaatgaaga gagattactt cgcaaaaagc gaacaaatat acaaaggagg acgagctatg
      541 attatcatgg atattaaagt tgacaacata tatgcattta aagattttca tataaatatg
      601 tcatatccaa agaaaatagt gaattcgact atagaaaatg aatttctgga agagaggaca
      661 aattttcggt acaaaaaagt taatatcatt atgggtacaa atgcaacagg aaaaacaact
      721 atgggtaagc tgttaatgtt gtttactaat tatttgaatg atggaggata taagcggttt
      781 actaatagaa ttgcagatgt aaaaaaagca gcaaaattgc agatcgattt tgtgacaaac
      841 gaaaatttat tatatagatt tgagatgaat gtcggtccga agacccaaaa aagttataca
      901 gaagaagatg tagatattaa gattttctat acaccaatag agacaagaga cagttatgaa
      961 acatgtgcgt caagattgga tatgtatgag tgtgaagaaa cgacatatga aaaagtaaat
     1021 acaaacggat ggaaattttc atatccgata gattcgtcag gggacaaggt ttatagtacg
     1081 atagaagaga atagtaaata tatatacata ttacagcaga ttttaaaaac acttgattct
     1141 tcggtggagg aagtagtaaa agtttctgaa gtagagaata catatgtaat aaaatggaaa
     1201 aattgttcag caattatcaa ggatggaaaa atcgctaatg gtgaggtaat gtccagtgga
     1261 actaaggcag ggcttgaaat atcttatata ataacctctc ttttatgtga tatgcatgat
     1321 ttatattatt gtgatgaatt attctcttat gtgaatagtg acattgaaaa ggcctgtttg
     1381 tcgattataa ttgaaaaact ctcggggaga aagcaattgt ttttcacaac acacaactca
     1441 gacatattag atatgcagct gccaaagcat tcatttacat ttctgaaaaa agatgtaaat
     1501 aacgaagatg attcaatcaa atgtattgcg gcatctcagt atttaaaaag aagcacggac
     1561 tcgttaaagc atgcggtgga aaatgatctg ttttgtacag cgcctgaatt acataggcta
     1621 tttgaaattg ctgatttgta attaggaggg atgcaaatga gaaaaagcgg tatttatcaa
     1681 tattatgtag agggtgaaga tgagagaagt ctgcttaaca cattgaagtt ggatctgcgt
     1741 tgtattgaga gtggaaaaat tgataagttt aatgtaattc aaagtcgttt tacgactgca
     1801 agaatgcgca cgctaaagac gggaacaaca gtagttctgg tatatgatac agatgtagag
     1861 atgaatacga aaattttaga tgaaaatata gcttttctga aaagacaaaa aggaataaaa
     1921 gaagtaattt gcattccgca agtaagaaat ttggaagatg aactagtgcg ggcctgtaat
     1981 ataaaaaata ttgtggattt gactaagagt cttacaaaag cagattataa aaaggattta
     2041 attaattgta gtaatttaag tgacagatta aaaaaatgta aatttgatat aacaaaaata
     2101 tgggcagaaa ttccaaaaaa caattttaaa aaatatggaa atgattccga aaaaataaaa
     2161 atcaagtcaa agaaatagtt ataggaaaag aagcgctact tccagcagtg tcattcttgt
     2221 gtaaatgaca ttaccggaag tggcgcttct ttttgttgga ctgtatgatt aatgtaacgt
     2281 gggaatatga aatttgtggt ggggatggga ttaaatatat gttagattgt ggttaaatgg
     2341 cgttgcaatt tggaatacta tcacgtaaca ttgaagaata agaagaaagc attaaatgaa
     2401 agaagataaa aacaggagca acatatgcaa cacacacagc aattattttt agaggcatta
     2461 aaagccgcat taaaaaatga acaggtagaa tggaataaca agttggaagc gcaggaatgg
     2521 atggacctgt tccgcatggc ggaagtgcac cagatccttc cgatgatcta tgaggccgta
     2581 taccgaagcc cggccgccgg gcaggcggat ccgcagatac tggctccggc gaaggcgcag
     2641 atggtgcgca cagtgatcat gcagacgcag aagacgggag agtttgagcc gctttacaga
     2701 tatctgagag agagcggaat ctgtccgtta gtggtgaaag ggatcgtgtg caggaacatt
     2761 tatccgaatc cggattatcg gatatccgga gatgaggatc tgctgatccg gccggaggat
     2821 tttagaaaat gccacgatct gttgcgcgaa tatggaatgc agacatcgga gcaggatatg
     2881 gatgcggaag aactggaatc ggtttacgaa gtaccatacg ggaagaaggg aagccttatc
     2941 tacatagagc tccacaagag cttattcccg ccggaatcag aggcatacgg ggatctgaac
     3001 cgcttttttg caaatgtaca tgaagatgcg attgatatca ggatcgatgg aacggatatc
     3061 cggacaatgg gatacacgga tcatctgttt tatctgatct gtcattcgtt caagcatttc
     3121 ctgcacagtg gattcgggat ccggcaggta tgcgacatca tattatttgc caatgaatac
     3181 ggggatgcga ttgactggga gaagattctg agacagtgct gcgagataca tgcggatctt
     3241 tttgctgcgg cattatttgc aatcggtgag aaatatctga cgtttgatcc tgggaaagcg
     3301 cattatccaa aggcatggcg caagatcagt gtggatgaga cggatatgct gatggatctt
     3361 ctggacagtg gtatctatgg caatgcgaat atgagccgga aacacagcag taatatgacg
     3421 ctggatgcgg tggcagcaga caagaatgga aagaaagccg ggaatacggt cttaaagtct
     3481 ttgttcccat cggcaaaaaa gctcgagggg cggtatccgt atcttaagaa acatccgatt
     3541 cttcttccga ttgcgtggac agaccgtatc ttaaaatacc gtaaagagac agtggcagga
     3601 ggggataacg ctgcggcaga ttccgtgaag attggaaatc agcggattga acttatgaaa
     3661 gagtatggga tcattaaaaa tgacataaaa cgttgatgac gaattatgca tatatatggt
     3721 ataatataca ggttgtatgc attttagaat gcagtgatgt gagagaaata cagaaaggga
     3781 aaagtatgaa aagaaagaaa agtacacaat tgctggcagt agcgctgaca gcagcaatgc
     3841 tggcgcagcc ggtaggtgca cagatggtgt tcgcggaagg taatgcggat gcagtgcagc
     3901 aggagcaggc agtaagcccg gcggcagaga caacggaagc agttcttaag agtggaacgg
     3961 cagtaattcc ggcggatgca gacctgaatc aggtgaaagc gatccttggt aagacattgg
     4021 ttgagaatgc ggatcaggtg gatctgaata gtctggagtg ggagtataag tgtgaaggta
     4081 agaccggatt gaccggatta gaagtatccg gtaatgaatc ttggggaagt attggaggat
     4141 ttacaagttc caagaagggc atatttggaa caacaacaac atatacccat ccatctctgg
     4201 caacaaataa agatgccaca tatccggtgc gtctgaaagg cacaacaacg gaagtaactc
     4261 tgaaaaagac gcagaaatta acttcagcta tattaataaa agataataca aatgtaaacc
     4321 ttgtatacaa cgaggacgga agcatcaatt ataacgcagt acgtcagaat atcttcaata
     4381 cagttgtaga atctacaact ccggagctga cggccaatga tgtaacgatt gaatattatg
     4441 caactgcaac aacaggagca gcagtaggtt ttggaaaaga atggatgccg ttagaaggtg
     4501 gaaagagtgg aacaccaatt gccctgacct acccggcaat gggagatgga acccagaaga
     4561 ttaagatttc ttatgctgga acggatgcat attccggagc aagtgcagaa gcaacggtta
     4621 atatcggtat cggcagagag cagtcagtga tcgcattcaa agagaatccg acgatcaagc
     4681 ttgtatataa cgatgatctc acagtagatt atgcggcagc taaagaagcg atcatgaatg
     4741 atgtgatcga cgttgagaac agcagcccgg aaggattatc acttgataac ctgacaatcg
     4801 agtactatgc aacaggagca ttaggaagtc ttgtaaaagc atgggcaccg atcgaaggcg
     4861 gcaagattaa cggtcttact tatcctggaa ttccggaagg aacacagaag atccgtgtta
     4921 catatgcggg agacaaagag aatactgccg taacagcaga gacagatatc aaggtaatag
     4981 atcgtgaaca gtcagcattc aatctgaatg aaccggcaga aggagctgct tcttatgaag
     5041 ttccgatggc atttaacgag gatcagacat atgattatga tgccacagcc aaagcaatct
     5101 acaatgcagt tgtagcatct acagttccgg agaatctgac agcagacgat gtaacaatca
     5161 gatacaacgc aggaacagat atgcttaaga actggcagcc actgaataca acagactgga
     5221 caagcacatt tacgaaattc ggacctggcg aatggacgat tcagttctct tgggcaggta
     5281 ataaagaata caaaggtgca acaacagagg taaaggttaa tgtaacagac aaccgtcttg
     5341 caagtgccct tgtatgcaaa gaaggcgtat cgtttactta taacatggat gcagctgtaa
     5401 tgaagcaggc aatctttgac aacgtgattg actgggagaa cagtacactt cctgcaaaag
     5461 atacattgac tgtggataac ttcacgatgg aatattatgg aagcaataca cttgccggtg
     5521 atatcgatgg cggagtgaaa cagtgggcac cgatcgaagg tggtaccgta acatttctga
     5581 cctatgcacg gatgggagca ggagagcaga agatccgcat tacttataaa ggaaatgcgc
     5641 agtatcgccc gtcagcacag acagaaagca cagtaacggt taataaagct aaggtaaaag
     5701 taaaagtaaa atcaaccagc atttatgcag gtgcaacgct gccggaagac tttgtaacaa
     5761 tgaatccagc agacaaattc gatgtataca cagtatacgg tggactgaca agcaatgcga
     5821 acctgtcact ttatctggat cttccggaca aatatacgaa cagtgcggtt ctgaagttgt
     5881 tagatccgat tgtagagaaa ctctatggaa agacatttac acagatgatg aacgacggaa
     5941 tgacagtagg agaactgaga caactgctca gtacacagga actgttagac cttcttgaga
     6001 agcttcatat tgacacaggt acatttggac agattcttac aataatcaat aagatgccat
     6061 ccgttgcaga ttctgtaaga gtatcattcg gtacaccgaa ccatgcaggt ctctatacag
     6121 taacagcagt tacagatagt aagaactacg agacaggtgt aggcatcgga acacttcttg
     6181 tgaagatgcg ttctaagggc gtgaagctta attggaatga gagattcgta aacggaaaga
     6241 ttactgcaga agaagcaaag aattttgatt tcaaagcaac actttcagca gacggagctg
     6301 taacgatcgc acaggataat gtacactatc tgtattcagg attcacaagc aaatggaaga
     6361 tctattccag cacaacaact cctccgacag agccgggaag ttatgtgatg acggtagtaa
     6421 cacttggtgg agattatcag gcagcaccga tcaaacgtgg attcaagatt acaaaataaa
     6481 ttgcaaaaga atattgtaaa gcggcccctg gttttaccgg gggctttttg tatcgtaatc
     6541 aagaaacaat taagatataa tatatctatg tggtggaaat gatacgaaag ctagatatta
     6601 aaattagata ttatatgaga ttaagggacg atagagataa gggttgacaa agaatttgtg
     6661 ctccgggaag gccgagaaga aggactccgg acaggaataa actatggaga actacaaaat
     6721 ctagttagaa tggtgctcaa aaaaatgcga aaagacgtct catgtgaaat aaccgcggaa
     6781 ctcttcgaag aaccggtaga aaagatccga aagatatatg aagtagcgga gaaatatgcg
     6841 ccggaatatg atattgagtc aatttgccga gagctggcgg cataaagtgc tttggttaca
     6901 ccgtaaggga atgtccttgt accttaccgg tggatttggt atagtataag gtattattct
     6961 gtaaaggagg ctcgtgatga aagagacagg agaatccgga tcaacaaaga ataaaaccgt
     7021 tatattactt ctgatcattc ttttgaccct gttatggttt gtcggagaga ttctggtttc
     7081 ttaccattgg atgaaagtga atcggtatcc ggtgcaggta cggaatctgc ggtatgcgga
     7141 tacggttaca gatgcaggat tcaagatggt ggtgatttcg gatcttcatg atcatgaatt
     7201 cgggaaagac aatgagaagc tgatccggtg tgtaaaagaa caggatccgg agatgatcat
     7261 tctggatggc gatatgctga atgaggattc gaagagtgac gaggtgccgg tcagactggt
     7321 aaaaggtctg gcagagattg cgccggtgta ttatgcgctt gggaatcatg aactggatta
     7381 tatcggcact gcagaaggga agaagatgca aaagcacccg gagaattccg aattggtgaa
     7441 ggatcttaca gatgccggcg catgtgtgct ggaagaaggt taccgggacg tggagatcgg
     7501 tggatgtaag gtgcgcatcg gtgggatgta tgaatatgca tttgctctgg atggagataa
     7561 cagtgcagag aatctgacag gtaatgtacg ggattttctg gaggagtttc agaatacaga
     7621 ccggtacaag attatgttgt gccacagacc ggatagtttt gtattcggtg atgcatccga
     7681 ttactggaag atcgatcttg tgatcagcgg acatgatcat ggaggacagg tagtcattcc
     7741 attcaaggga ggactatatg gtggtgatca gggatggttc ccgccatatg tgcatggact
     7801 gtaccggaca ggaaggatcc ggctgttcgt gacgagtgga ttaagcagtg agaaacagaa
     7861 gctcccgaga tggaataacc ggccggagat tgcggtgctt aacgtacact gatcagaggg
     7921 atgaagaggt aaaaagatgg ttagaaggac agtcgttccg gtgatgtgtc atcaaagatt
     7981 actgcggaca gtgtgttgga cggagatctt acatcaaata tcaagtattc actggagaag
     8041 acggtcaata cgcaggctgc gggtgagtat ccgatcgagt tcagggttat ggaccgcggc
     8101 gggaatacag tgtatctgaa gacgcagatc agtatttccg ataaaagtta tgcagggatt
     8161 gatgtgaaat taaaagatta tctgatctac ctttctgtcg gagatgcatt tgatccaaat
     8221 gcatactttg attcggcaga taaagaaggc gagcttacgg tgcagtcgaa tgtaaatact
     8281 gcaaaggcag gatcctaaag agtataataa gataaaaaag aacccgacac ggctgtcata
     8341 tcatgatagc gtgcaggttc ctttggtttc acatgcatta ttctgatgcc gaatgggata
     8401 tcagaaattt gttgaataat ttgacaatct gactccgctt acgtaaggtc agtggaatac
     8461 agtcatcgtt ggttaattga atctcggtat ccagaatgtc ctgaatatag ttcatgttta
     8521 caagatagct gcgataacaa cggataaaag aattgtcatt cagcgtgctc tcgatatgat
     8581 ttaacgccat gttggtttcg taagtttttc tggaagtatg tatcatgcat tttcttccaa
     8641 tgctttcaat ataaaaaatc tcagaaaccg ggatgtgata taaaagccag ttggaatata
     8701 cattgagtgt atgggttgaa gggaatatcg gaagcaaaag tctggtaaag actttctcaa
     8761 aatcttcttc tctgattggc ttcagaatgt atccttcaac tccaagatta tagcttgcca
     8821 ggcaatgttc agtgcgtttg gtcgtgaaga taattattgg agggtttgga ccatctttca
     8881 attgtctggc agtctctata ccatctgttc ccggcattaa aattcccaaa aaaatgaggg
     8941 aatattcttt cggggatgct aacaactcgt ctgttgaagt aaaggtatct acttctaata
     9001 atgcatgatt gagcatatga ttcttaatat tggcgtccaa gaactcacta atacgtgtta
     9061 tgtcggtatc atatctatcg caaattgcaa tattcatata tagccccctt cccgaacaga
     9121 taaaacgtat ttttatataa atataaatag aatatgctct atataattat aatataacat
     9181 agattaagag tgaaaagata gaaaaatgat acaaatggac agtaaatgga atatattaac
     9241 agaaaaatat aagaatttgg agcaatcaaa cagaaaaata taaaattaat gcgaagattt
     9301 gtcgaaaaac gtagaaaaat taaagcaata ttttgatgtt gcaggaagaa aactgcgatg
     9361 gtatgataaa aaagaaattg agtactattt aatgtataca taaaaaacaa tgcgaaggat
     9421 gtgctgagaa ttgtaccata atttgcgaaa aaacggaacg gacgaagtgc ggatagagaa
     9481 aagcaggttg aggaatatga aagttgtaga tacaagagaa tatgttggta tgcttaagga
     9541 actgacggaa gagggaaagg aagtcagcat gctggtcttt ggaagcagta tggcaccgtt
     9601 tctgatccat gcaagggata tgatatattt caaaaagccg gacagagagc ttcaaaaagg
     9661 tgatattgta ttttttcgaa gaaagagcgg gcagtttgtc atgcaccgga tatggaagat
     9721 caggccggag gggtattata tcgtgggcga tgcacagaca cagatagaag gaccggtaaa
     9781 gagagagcag atatttgctc tgatcaccaa agtcagaaga aaagaaaagt ggctggagcc
     9841 gggagatttc tggtgggaat tcttcgagca tgtatggctg catatgattc cgctccgccg
     9901 ggggattatg tggtgttatg cgaaggtgat acggtgaccc ggttgcatac agacggcggc
     9961 aatgctatga tggaacaata aaatcaagga gaaaagttat atgaagattg taaaggaatt
    10021 tatattaagg gagatcgcag gtgaatgtgt actggtgccg acgggggcaa cttcgcagga
    10081 gttcaatgga atgatcacga tcagtgatac ggctaaattc atctgggaga atatcgaaaa
    10141 ggtggatagc ctggaagaga tgatccggat ggtgctggat acatatgaga ttgatgaaga
    10201 gactgcaaga agggatacga tcgcttttgt cggtgcgctt gtggagaatg gctttattga
    10261 gtgtacgagg gaagatggaa catggtagaa cagaatgagt caatcacccg cctgtacagg
    10321 atcgggcata cggagattga gattacggct ccgttatcta tgaaaagtcc gcggaatctg
    10381 gaaaaattcc ggatcgggca ggcaaagagg ccggatgatg aggttatcca ttatcaggta
    10441 gagatgacag agaaccttga tgagatcaaa gaagatcttc tggggaaaaa gacgggaaga
    10501 gtgatctacc gtgataatct tacggtattt cagacgtcgg gcggggaatg ccgctttatt
    10561 aattttcttg gaatggactg gcattatgcg gtgagcagcc aggagggtgt aaatcaatat
    10621 catgtctggt ttgttcccga agtggcagag atgcttgacc aggatacggt atacctggcg
    10681 gccttctcgc tggaaaagca ggctattaaa gatcattcga tgatactgca ttctgcatat
    10741 atgtgttatg aagatacggc agtgctcttt tctgcgccgt ctgagacggg aaaatccacg
    10801 caggcaggct tgtgggaaaa gtatcgcgga acatggacgg tgaatggcga ccgttcgctt
    10861 cttatccgtg aagaagatgg atggtatgcg aacggatggc cggtatgtgg aagctcagag
    10921 atctgtaaca ataagtccta tccggtcaga gcaatcgtta tgctgtcaca ggcgaaagaa
    10981 aatcgtatca gccgtctgaa agggcttgag gctctgcgga aagtaatgga acagattacg
    11041 atcaatgcat ggaacagcga gtttcagata caggcaatgg atgagcttga gattttactg
    11101 aaggaggttc cggtatatca tctggagtgc gacatatccg aagatgcggt gagatgtctg
    11161 gaagatgtac ttgccggtgg acgaggagag gaataaatgc aggaaaataa tgataaaaat
    11221 caaggaaaga acggcttgtc tttcgagtct ctggatattc tgatcgcgaa gtggaaagat
    11281 gggacatttt cggagatcat tgatgactgg aaatggatat tcagctacag tgtccggtat
    11341 aagtgggcaa tcgtgttcta tacgatcctt ggtatcttca gtacttctat gggacttgtc
    11401 agcagtgtgg cggggaaata tctgatcgat atcattaccg ggtataagac gaataaactg
    11461 atgatcctga tcattgttat ggtaggaagt tcattgttca gccttctgtt cagcagcatt
    11521 atcagccgta tctcgaccaa attaagtatt tatatcaata atgatatcca ggcggatata
    11581 ttcgataaga ttgtggatgc cgactggctg gagatcaata agtattccaa cggggatgtg
    11641 ttgaaccgct tcaacggaga tatcggaacg gtcagcagca atgcgatcag ctggctcccg
    11701 acgatcgtga tcgcaatcta taatttcata gcgacatttc tggttattct tcattataat
    11761 gcggtgatgg caattctggc actggcaagc gcaccgttca tgcttctgat gtcgaggttc
    11821 atgatcaaga agcagcgaga atatagtcag aagaccaggg aaatgagcag taagctgatg
    11881 acgttcgagg tggaagcatt ctacaatttt gatacgatca aatcatttgg cattgcaccg
    11941 cactacagcc ggttaatgcg ctggtggcag ggcaaattca aagatgtcag tctggagtac
    12001 aatatgttct ccatcaagac caatatcctg ttgtcggtta tgggcacggg agtggaattt
    12061 attgcgttcg gatattgtct attcttactg tggacccata cgatcacata cggaacgatg
    12121 acattattcc tgcaacagag aagcaatctg tcaggcgcat tcaataacgt ggtgtcgatc
    12181 attccgtcat ttctaaatag ttctgtgtct gcacacagaa tccgagagct ggtagagctt
    12241 ccgaaagagg tgcatatcag tgagagtgag gagctggatc cgttcgcaga ggatggattc
    12301 gaggtgctga tgaaggatgt gaatttcgca tacgtagaag ggacaagagt tattacggat
    12361 tcgtatttta aagcgtgtcc gggtgagatc gtggcacttg tgggaccttc aggagaagga
    12421 aagacgacga tgatccgtct gatccttgga ctgatccgtc cgcaggaagg agaggctgtg
    12481 atcgttgcat ccaacggaag agagatcgtc ctgaatgcgg agacgagaca tttcttcgcc
    12541 tatgtacctc agggaaatac gatcctttcc ggtacgattg ctgagaatat gcggatggtc
    12601 aaagaagatg ctacggatga agagattatc gaggctttga agattgcctg tgcatgggaa
    12661 tttgtagaga agcttccgga tacgattaac agtgcgctcg gagaacgtgg acgcggtctt
    12721 tcggaaggac aggcacagcg catctctatt gcacgtgcag ttcttcgtaa tgcaccgatc
    12781 cttctgttag acgaggcgac gtcggcgctg gatgtaacaa cggagcgaaa ggtactgcgt
    12841 aacattatcg agcagaaacc gaacaagacc tgtatcgtga cgacacacag accaagtgtg
    12901 ttgaatatgt gccagagggt gtaccgtgtt atggagacga aggttacgga attggacgag
    12961 gaagaatcaa gccggatggc gatagatttc taattagtac aagtaattat tagtagaatg
    13021 tgcataatca cgcataaaag tgtaataaaa cgacgtgaaa tgacaagtaa acagtattga
    13081 aaatattaaa aaatgtagtt ataattatag ataataagaa ttgtctataa caataaggat
    13141 tttagtattg aatttagcat tagactttta tataatagag taatatagac agaggtttat
    13201 gggtaacaag agtaaaataa taaaaggagt gtataagtat gaagagggcg tatgttagac
    13261 ctactatggt aggcgaaaga tttgtagcta atgagtatgt agcagcttgt ggcgataaag
    13321 aaaaggtgta taaatttaga tgtgatgctg gcggtggtaa aagtggagag gtatatctag
    13381 aaactaataa tataaaggga ttccagccat taggcgatac gtatctaagt tcgtatcatg
    13441 cttgtgggat aacacatgat gcgagtactg cagataaatt tttggatggc tattatgtga
    13501 gaggattgaa ggtgacgccg gttaaagtat ggcgtggaga aaagggtgat aatactcatt
    13561 gtacaacaaa gattaatata aaagagtggg agacagcaaa gtcataaaaa ataaatctat
    13621 atacatatcg aaaaagaacc ggattcccgg ttctttttta aaatctgcag gaaatatcga
    13681 ggaaccaata tggaattaat ggaagatgga acgacaatag agcaacagat gtttgcaatg
    13741 gcgacagaga agaaagtgcc gttatatgga gtgctggagt tgctaccgct ttgtaatctg
    13801 aactgtgata tgtgttacgt gcgtatgagc agagaagaga tggaagaggt gggaaggctg
    13861 cgcacgatgg aagaatggac gaaaacggca gaagatatga tgagagccgg gacgctgttt
    13921 gttcttttga cgggtggaga gccgctgctg tatccacatt tccgcgagtt atatcaaaaa
    13981 ctgcgtgaac tggggatgat tattacgatt aacacgaacg gaacgttgat cgatgaggcg
    14041 tgggcagatt tttttgcgga aaataaacca agaagaatca atattacatt atatggtgca
    14101 agcaatgaga cctatgagcg tttgtgtcat tatccgggag gattcgacaa ggcggtgaac
    14161 ggcatccggc ttttgcggga gaggaacatt gatgtgaaag tgaatggaag tcttgcaaag
    14221 gcgaatgtgg atgacaggat gaagatcata gagcttggtg aatctctgga tgctccggtg
    14281 cggatcgata cttatatgta tccgtccgtg agagaacgaa atcatgctta taataatcag
    14341 gccagactgg atccggagat ggcggcaaaa gcaagagtgg aagttttgcg aagagagatg
    14401 ggagaagaag tatttgccca ataccgcaag atccaattag acgaagcaga gaatactccg
    14461 gaaggagagg cagttccggg acagatgacg tgtcgtgccg gtaagagctc ttttgtggtg
    14521 aactggcagg gcgagatgcg ctcctgtgtg gtactggata agccaagcat accgcttcgg
    14581 gatgtggagt ttgaggaagc gtggaagttt acaaaaaaag aaacagagag tcttagaatt
    14641 tcggccagat gcagtagttg taagcttaga aaggtatgta acacttgtgt ggcagcggca
    14701 attgcggaga ccggaaaggc agacggcgta ccggaatatc tgtgcagata cacagaagca
    14761 acggtcagat atctgaagga gacaagtaag aaatagtaat gaaatagtaa gtatcgtttt
    14821 ctttactcca taatttgaaa atgatataat aaaaaagact ataaattaca aaggatgatg
    14881 agatgataga tatacatgcg catatactcc cggggattga tgacggagcc gaagatatgt
    14941 atgatacgct ggagatggca cgtatggcag cagacagcgg agtggacaag atcatagcga
    15001 ccccgcattg caatatcccg ggaatgtatg ggaattattt cgggaaagaa tatattgaca
    15061 gatatgaaag tgtggtcaga gcggtcagaa aagagaagat cccgatagag atcctgccgg
    15121 gaatggaagt attttcgaca gaagaccttc cggagctgat cgtgaatcat aagatcatgc
    15181 cgcttaacca gagccggtac atactgatgg aatttgcatt tgatgaagat cctgaatttg
    15241 cggattctat tctgaagaga gttgaagaag tcggagcaag accggtgatc gcccatgcgg
    15301 aaaggtatga atttatacag gattatccgc agatcgcgta ccgctggttc agaaaaggat
    15361 atgtgattca ggcgaataag ggaagcttcc tcggaagatt cggaggagga ccgaagcgtg
    15421 cggccgacag tcttttgcgg cataatctga tttctgtgat cgcaagtgat gcacacagtc
    15481 cacttcagag gacaccgtat atgctggatg cgtatgaaga actgagccgg gagtattccg
    15541 agaaccatct ggatgtgctg tttcagtata atccggcaag gatctgtgac aaccgggaga
    15601 tcctgagatt agaaccggtc ccgtattccg gacggcaaca gctatattaa caataaagga
    15661 gaagaattat gaggagacta aaaatagcag tatgcctgat atttgtggca tcctgtgtca
    15721 tatttgccgg atatactgtg aagtccaaga tgttggaaga ccatacaccg ccggtgatca
    15781 actgtaagga taagacggtg acactgagtg tgcagaccga tcagaagaag cagaagaaag
    15841 cacttctgaa aggtgtcaaa gcagaagaca accgtgacgg tgacctgaca tcgtctgtac
    15901 gtatcgcttc gatgtcgcat tttattgcgc cgggcaagcg taccattacg tatgtggtat
    15961 tcgataaggc gaatcaggta gggacactgg aaagaaccgt acagtacaaa gattacacgc
    16021 cgccgaagat ccatctgaag gcaccgctta gatattcgac aacagaggtg gggaaggcga
    16081 accttacgga gaatatgaag gcagaggatt gccttgacgg tgacctgacc agtcagatac
    16141 gtaccagtct ggatgatggt atgtataatg cagctgcagg aatttacaaa gtgaccgtac
    16201 aggtaagtaa cagtgcgggt gatgtgtgtt cagtgcctct cgaagtgacc gtaacagaat
    16261 ccggtgacag acaggagcag atgaaagaat atccggtatt atcggattat atcgcatata
    16321 caacagtagg acatgaaatc gatccgatgt cttatgtcaa aggtatggag atgaatggtg
    16381 caacatatac gtatgcggat gacggagagg ctcttgcagg tacaagagaa gcgatcagtg
    16441 tgaaatcaga agtggattat tccaaggcag gggtttatcc ggtggaatat ttttatacgg
    16501 cagaaggagc accgactgcg gtaacaaagt tattcgttgt agtacaggac caggaaggag
    16561 cgcaggatgg agagtagtaa tagaaatgac atgccggtat ttatggataa tgatctggat
    16621 ccatatacgc ttgtgcatga tatagtgtcc aactggtggg tgattattct gggggcaatt
    16681 gcgggagcac ttctgactta tgtagtcgta agcagcagat atgttcctga gtatacaacg
    16741 caggcgacat ttgtagtgtc atccagaggg gatgcgaatg catacagtaa tctgagttcg
    16801 gccaacacaa tggcgaagac attcgagaag atattaaaaa gtaacatcat ggagaaaaag
    16861 atctgtgaga agctgaaagt agaggagctg gatgcagata tccatgcgaa ggtgctggaa
    16921 gggacgaata tgctggtctt aagtgtgacg gcggatacac cgaaggagtc catagacatt
    16981 atccgtacgg tcatggacaa ctacagcagc gtatcgttgt ataccgtggg cagtgcggtt
    17041 atggatgtgc tggaggagcc gaagattccg tatacaccgg ataatccgct ggatgcaggc
    17101 agacaggcca agaagggcgg acttgtggca ggagcactgg tgctcatcct cctcggaatg
    17161 ttctcttata tgaagaatac tattaaacag gagaatgaga tcgagaagaa gctggatgcc
    17221 agaagtctcg gagccatcag ttatgaatgg aaatataaga cgatccggga tatattccgg
    17281 cgtaagaaaa aagcaatcct ggttgatgat ccggtagcaa gtttccggtt cgtggaaagt
    17341 tataagaaac tggcggccaa ggtagaatac cggatggcaa agaatgaaca gaaagtcctc
    17401 gtggtaacca gtgtatctga aaatgaagga aaatctacgg ttgccgccaa tctggcgatc
    17461 acgctggcag aacagtccaa gagggtactg ctggtagatg gcgatatccg aagaccgtcg
    17521 cagttcctga tctttggtat ggagccaaaa gaggagaatg aactgggaga gtatctgaaa
    17581 ggaaacagag cacttgcaga tgtcatggtt ccatgtacca gaaagcatat gttgttcatg
    17641 ggtgggaaga actgctattc ctcatcgacg gagatgctta actcggagtc attttttaag
    17701 ctaatgactg catgtaggaa atttgtggat tatgtgatca ttgatacacc accggcagga
    17761 atcatcggag atgcgcagat atttgcacat tgtgcagatg cggttatgat cgtgtcaagg
    17821 cagaattata tgctggctga agacatcaat gaagtaatgg acgctttccg tgacaaggaa
    17881 ggtaaggtac tgggagttgt actgaacggt gtaagatcgt tctccggcct ggtggacagt
    17941 ccggtgggac attattatgg taaatacagc aaatacggac gttacggcaa ttatggaaga
    18001 agtaaaggaa tgtagagtat atgggcgatt atagagacaa atcaggaagt gaacgtgtag
    18061 atgcgcctga gaagattgat ctgacaaatg ttatgttgga tgtttatcat ggtgtgaaga
    18121 ggctgtggtg gctgttcatc gggcttataa ttatttgcgc agtacagtct tatttctcgg
    18181 tgagtaccag ttatcagtca aaatatgtgg catcggcaac agtgtcggtg acatctgtcg
    18241 gcggcatgga ctatgtggat gcacagtctg cccagcagat ggcagaagtg ttcccgtata
    18301 ttcttaccag tggtgtactg aaggatgtag ttgctgagga tatggggctt gattccatgc
    18361 cgggatcgat cgatgttaaa gcggatgacg gaacgaatct tctgacaata tccgtatcgg
    18421 gaaatgatcc gcagatggca tataagacgt taaaatcagt cataaagaat tatccgaaag
    18481 ttgcggaatt cgtacttgga gagaccaagc ttacgattct ggatgagacc ggtatcccga
    18541 cagataccaa acgtgtggag gttatacgtg gatcttacaa gcgtggagct ttaaaaggtg
    18601 cgatcatagg ttgtgtgatt cttctgctgt atgtgctttc cagaaggact gtgaagtcaa
    18661 gaaaggatct gaagaagaat atcaatctgc aggatctggg aagtatcccg tatgtccgca
    18721 cgaaaaagcg taaaaaagag acattttata attcagtgag cctgttaaat gaaagaatct
    18781 ccatgagtta tctggaagcg ataagaaagc ttcgtatccg tgtgatgaaa gatgtggaga
    18841 aaaaggaata ccagaccctg cttgttacga gttcgatccc gggagaaggt aagacgacac
    18901 tttcggcgaa tctggcaatt tccattgcac agcagggaaa gaaagtactg ctggtcgact
    18961 gtgatcttag aaatccttcg attgcgggag tgatgaacga gcaggaacca catccgggac
    19021 ttggctcggt tcttaagaaa gaagtgccgt tatctgaagc aattaccaat gtaaagcttc
    19081 cgaaggaaag aacgaatgag aacggaagcc ttcatgtcat tttcggcggc gcaccggatg
    19141 gagagaattc gctgttgata ggaagcggac gtatgagagc actgatcgaa gctctgaagt
    19201 ccaaatatga cattatcatc ctggatactg cgccatccga acttctggca gatgcaccgc
    19261 ttttgggcaa atatgtagat gcggcccttt atgtgatccg ctatgattat acgaagcttc
    19321 gcgagatcag agaaggtgta gaaagccttg cattaagtgg aatcgatatg ctgggatatg
    19381 tgttcaatgg tgataattca tccggcggac aaggatacgg ctatggatac agacgttacg
    19441 gcaattacgg cagttatgga agccactacg gaagttatgg taaatacgga gcttacggtc
    19501 actatggcaa gatggaaaaa ggttcgacgg acaagtttgg ccgtgtgatc aaggactagg
    19561 gggacacaga cagatgaagt tttttcgaaa acacaaaaaa cgtaagattg caggaattat
    19621 aatattattg atcgtattgc tgattggcgg tatctacggg tcgatctggt ggaaattcta
    19681 cggggactct gtaggggttg tgtcggcaga caaagtagat ccgaaagcaa agaaagttaa
    19741 gatcgccaaa gaaaagagaa aagacaagga tgtatataat gtccttctgg taggtacgga
    19801 ttccagagat ccggatgcgg accggggacg ttcggatagt atgatgatgg tatcctttaa
    19861 caaaaaagaa ggaaaatcaa cagcaatctc attcctgaga gactcgctgg ttgatattga
    19921 cggacatgga aagagccgtc tgggccatac ttatgcatac ggcggagtgg gacttacgat
    19981 caacacgatc aataagacat atgatcttga tattcagaat tatattacga tcagctttga
    20041 tgatctggta aatgtaatcg atgagattgg cggtgtgacc gtattcatca gtgaagaaga
    20101 ggctgcttat tacagagaga atggtatgcc ggatattcag gccggagatg tgacactgac
    20161 cggatcccag gcacttgcgc atgtgagaaa ccgtacactg ggcaatgatt ttgaaagaac
    20221 aagacgtcag agaagtgtaa tgtatggaat ctaccgtaag attatggaga agaaggatcc
    20281 aagtgcgtta ctgcctctga tcaattacgc tgtaaatcat gtaaggacga atatgagtgt
    20341 atcggagatg tactctatgg caaaagatgt tctgtcggta gacgatctga agatgcagca
    20401 gacatgcatt ccacaggacg gaacgtatac agatatcact tatgagggta tgcaggtact
    20461 gaaggttgat tttgatgcga ataaaaagaa gatcgagcag ttgttatatt aaagtgattt
    20521 acaaaagatg aatataaggg gacagtaaac gggcgagtat aatgaaacag agcaagaaag
    20581 ttgtggccag gattataata ttgatcttgg ccttatttac agtaataccg ggaacggtaa
    20641 gccagaaagt atatgcggaa cctggcggca gtgagagcag tcaggcggca gacgcatcaa
    20701 aagatgattc caataagaag gaagagaaaa aagaagaaga catgacgccg gaagagcggg
    20761 aaaagaaggc agaagaagat gcctataaga tggagatcca gtcgaacggt tggaagaact
    20821 ggccaaaagg accgggcaca tacggtgaag ctgcaatcgt gatggatgcg ggaacaggaa
    20881 gcatcttata tgcgaaaaat attgatgaac atgagtaccc ggcaagtatc acaaaagtcc
    20941 tgaccagtct tattgcttta aaatacggca atctgtcaga caaggtaaca ttttccaatg
    21001 actgcatatc ttttatgcag ccgggagatt cttcggttgg attaaaagaa ggtaatgtga
    21061 tctcgctgga acaggcatta tatgcgacgc tgcttgcctc agcgaatgaa gcagcttatg
    21121 cggtggcgga aaatgtcggg aaaaatgccg gatatgatta caactggttc atccagcaga
    21181 tgaacgaaga atgtaaaagt cttggcggca ataattccaa tttcgtcaat gcgaacgggc
    21241 ttcatgatga caatcattat acatgtgcgc gcgatatggc tttgatcggc agagagatct
    21301 ggcgctatcc ggaattcctg aagatctgcc aggagcagag ttataagatc ccggcatccg
    21361 atacgacgga agaacatgta tttccacagc atcataagat gctgatcaaa gaaaataaaa
    21421 attattacca gtatgcggtt gcaggaaaga caggatatac atcgaatgca ttatctacgc
    21481 tgatcacatt ggccgataat ggcaatatga aactggtatg tgtcgtactt cggacacatg
    21541 gtgtgaatat atatccggat acgaagaatc tgttcgaata tgcatttaac aatttccaga
    21601 agatccaggt ggcagatgag aagaaaccgg atgaagtaga gaaatttata tcggctgcgg
    21661 atagccagag tgctgtatcg gcacagtcag atggaagtga ggatacagaa tccgtgcaga
    21721 caggcggaaa tgaatatcag ccgctggagg acggacatgt gatcctgccg aaggatgtat
    21781 catacaaaga tatagattat gaaattacgg atgtagatga agataccgga gagggaacga
    21841 tccggtatat atatgacggc catcaggttg gaagtgcaac ggcaaaattt acggataagt
    21901 atttacagaa agtaagcacc aggaaagaac gtgtggacag taagccgaag gatgtggata
    21961 attccggtga ttcgaagaaa aacggtggaa aatcaagtga aaagagtatc tggaagaatt
    22021 ttctgcaaaa agtaaaagca gtatgggatt tcggacagaa aaaatttgcc ggaaaatcaa
    22081 gtacagaaaa atatatgatc gccggaggat gcgtagcact ggtgattctg atcttcagtc
    22141 tgatcgtgct gcttatacgc cgtagaagat aaaaaataga aaatatatga aaaatacgga
    22201 gaaaaaccga ttaaaaaagg taaaaaccct tgacggattt taggattact gcatataata
    22261 aggaatgtga aaaacgctga cgaagacagt aggatataac agaacgcagc agcgagccgg
    22321 ggatggtgga agtccggtac aagtaagata tatctgaata tcacttctga gttgcagatt
    22381 ttgaacggtt tcagggtgtg aacaaaagcc tgactgccaa gtaaaaactg acggcattcc
    22441 tccgttacag ggaagacata tgatggtatg ttaggtggtt tataaacgta agtacagctt
    22501 tcgtcctata cagggcggaa gcttttttaa ttctatgttt taattttatg gaggtaaata
    22561 tgtataagaa agtttctacg gatcttaatt ttgtagacag agaaaaacag acagagaaat
    22621 tctgggaaga caatgacatc ttcagaaaaa gtatgcgtga ccgtgaaggc aacgagatct
    22681 atatgttcta cgacggccct ccgacagcca acggaaaacc gcacatcgga cacgttctga
    22741 cacgtgttat caaggatatg attccaagat accgcacaat gaaaggatac gaagttccaa
    22801 gaaaggccgg atgggataca cacggacttc ctgtagagct cgaagttgag aagcttctcg
    22861 gactggacgg aaaagaccag atcgaaaaat acggtatcga accatttatc aagaaatgta
    22921 aagaaagcgt atggaaatac aaaggtatgt gggaggattt ctctaatacc gtaggcttct
    22981 gggctgacat ggatgaccca tatgtaacat acgataacaa cttcatcgag tctgagtggt
    23041 gggcactcaa gagaatctgg gacaagaagc tcctttacaa aggattcaag atcgtgcctt
    23101 actgccctcg ttgtggaact ccgctttccg cacaggaagt agcgcaaggg tataaagatg
    23161 taaaagaacg ttctgcaatt gttcgtttca aagtagtagg agaggatgca tacttcctcg
    23221 catggacaac tacaccatgg acacttccat ccaacatcgc actctgcgta aacccggaag
    23281 aagactatgc gaaagtaaaa gctgctgacg gatatactta ctacatggca gtagctcttc
    23341 ttgatacagt acttggaaaa cttgcagaag aaggacagaa agcatacgag attcttgaga
    23401 catacaaagg taaagatctc gaatacaaag aatatgagcc attataccag tgtgcttatg
    23461 actgcgcttc taagcagaac aagaaagcat tcttcgttac atgtgatact tatgtaacac
    23521 tgacagatgg taccggtgtt gttcatatcg cgcctgcatt tggtgaagac gatgccaagg
    23581 ttggacgtaa gtatgacatg ccattcgtac agttagtaga cgaaaaaggt aacatgggag
    23641 agacgactcc atttgccgga ttattcgtta agaaggctga cccggaagta ttaaaagacc
    23701 tcgacggacg tggacttctc tacgatgcac cgaagttcga gcacagctat ccacactgct
    23761 ggagatgtga tacaccactt atctactacg ctcgtgaatc atggttcatc aagatgacag
    23821 aagtaaaaga tgacctgatc gctaacaaca acacaatcaa ctggattccg gaaagtatcg
    23881 gtaaaggacg tttcggcgac tggattgaga atgttcagga ctggggtatc agccgtaacc
    23941 gttactgggg aactccactg aatatctggg aatgtgagtg cggacaccag cattcgatcg
    24001 gaagcatcga agagctgaaa gaaatgtctg acaactgccc ggatgatatc gaacttcacc
    24061 gtccatacat cgacgatgta acgatcaagt gcccatgctg cggcaaacag atgcacagag
    24121 taccggaagt tatcgactgc tggttcgaca gtggatctat gccatttgca cagcaccact
    24181 atccatttga gaataaagaa ttatttgaaa agcagttccc tgcagacttc atttccgagg
    24241 ctgttgacca gacccgtgga tggttctact cactgcttgc aatctcaaca ctgatcttca
    24301 acaaagcgcc atacaagaac gttatcgtac ttggacacgt gcaggatgag aacggtcaga
    24361 agatgagtaa gtccaaagga aatgcagttg atccattcga tgcactggag aaatacggcg
    24421 cagatgcgat ccgctggtac ttctatgtca acagtgcacc gtggctgccg aaccgtttcc
    24481 acggaaaagc cgttgtagaa ggacagagaa agttcatggg aacattgtgg aacacatatg
    24541 cgttcttcgt actgtatgca aatatcgatg atttcgatgc aacaaaatat acattagact
    24601 acgacaaact gtctgttatg gataaatggc ttctgtctaa gctgaattca gcaatcaagg
    24661 cagtagacta tgatctgtcc aactacaaga ttccagaggc tgcaaaggca cttcagagct
    24721 tcgtagacga catgagtaac tggtatgtaa gacgaagccg tgaacgtttc tgggctaagg
    24781 gaatggagca ggataa
//
