LOCUS       NZ_JADNJR010000017     21751 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Dorea longicatena strain 1001136B_160425_G1
            NODE_17_length_80286_cov_51.8027, whole genome shotgun sequence.
ACCESSION   NZ_JADNJR010000017
VERSION     NZ_JADNJR010000017.1
KEYWORDS    WGS; RefSeq.
SOURCE      Dorea longicatena
  ORGANISM  Dorea longicatena
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Dorea.
REFERENCE   1  (bases 1 to 80286)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 80286)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.58x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 03:07:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,053
            CDSs (total)                      :: 2,995
            Genes (coding)                    :: 2,936
            CDSs (with protein)               :: 2,936
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 10 of 59
            Pseudo Genes (incomplete)         :: 53 of 59
            Pseudo Genes (internal stop)      :: 5 of 59
            Pseudo Genes (multiple problems)  :: 7 of 59
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:58:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 36687
            Orig. end                         :: 58438
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADNJR010000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21751
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21751
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21751
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11751](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11751
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(270..285)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            705..1481
                     /gene="sigG"
                     /locus_tag="I2E58_RS11140"
     CDS             705..1481
                     /codon_start=1
                     /gene="sigG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009268365.1"
                     /locus_tag="I2E58_RS11140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sporulation sigma factor SigG"
                     /protein_id="WP_006427094.1"
                     /transl_table=11
                     /translation="MAQGKVEICGVNTAKLPILNEKEKEALFVRIKAGDQEAKEEYIKG
                     NLRLVLSVIRRFGASGENPDDLFQIGCIGLIKAINNFNTELEVKFSTYAVPMIIGEIRR
                     YMRDNNSIRVSRSLRDTAYKAIYAKENYMKKNQKEPTVQEIAEEIGISKEDIVFALDAI
                     QVPMSLQEPVYNDGGDALYVMDQLSDQTNKEEKWIEDLSLEEAMKHLGERERYIIKLRF
                     FQGKTQMEVADEIQISQAQVSRLEKNALKTMRQYLI"
     gene            1596..2243
                     /locus_tag="I2E58_RS11145"
     CDS             1596..2243
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009248623.1"
                     /locus_tag="I2E58_RS11145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD family hydrolase"
                     /protein_id="WP_022415000.1"
                     /sec_met_domain="HAD_2 (E-value: 2.5e-42, bitscore: 137.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKACIFDLDGTLTNTLESMTYSVNLTLKEMGLSQITKDQCRMFVG
                     NGARVLIEESLKVSGDPKASRIEEGMKIYGRIFDQNCTYHVTLYEGIPEMLKALKDRGI
                     HLAVLSNKPDRQTVKVVKEIFGDNIFDYAQGQKDGIRRKPEPDGVWYLMEQMQVSKEEC
                     LYIGDSEVDAATGKNAGLKTIGVLWGFRDRKTLETAGADHLIERPEELLQFV"
     gene            2270..2533
                     /locus_tag="I2E58_RS11150"
     CDS             2270..2533
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440037.1"
                     /locus_tag="I2E58_RS11150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_006427092.1"
                     /transl_table=11
                     /translation="MYEYDEECLKTFILNQGQLFDEPVAETLEEAEAFLEDCMASIVDS
                     IEEVKEFLDQEGMDISGMSDEEIEEASEVFALPDGRYLIVEG"
     gene            complement(2576..3010)
                     /locus_tag="I2E58_RS11155"
     CDS             complement(2576..3010)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008976454.1"
                     /locus_tag="I2E58_RS11155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_195464975.1"
                     /transl_table=11
                     /translation="MSSKTKIVVLHMKEIIYTVIFAVLAIVLILLLIFMFRPGHHSGSN
                     DKKIYTPGIYTSDITLNNTALEVEVTVDETHINSIRFTNLNDSITTMYPFIEPAIEDIA
                     EQVYKKQSLENIQYSSDTPYTSQLIVQAIESALKKAETTK"
     gene            3156..3740
                     /gene="pth"
                     /locus_tag="I2E58_RS11160"
     CDS             3156..3740
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="pth"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004605077.1"
                     /locus_tag="I2E58_RS11160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_006427089.1"
                     /transl_table=11
                     /translation="MFIIAGLGNPTLQYEGTRHNVGFDVIDMLADRYNISVDGRKGRAL
                     VGKGIIEGQKVLLVKPQTYMNLSGESLRELVNYYKIDEEHELLVIYDDISLDVGQLRIR
                     KKGSAGGHNGIKNIIANLGTDVFPRIKIGVGEKPKKYDLADYVLGHFSKEDRELMEEGY
                     DRADHAVGMILNGEIEAAMNQYNRKVKPKEA"
     gene            3744..7124
                     /gene="mfd"
                     /locus_tag="I2E58_RS11165"
     CDS             3744..7124
                     /GO_function="GO:0003690 - double-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="mfd"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009244391.1"
                     /locus_tag="I2E58_RS11165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcription-repair coupling factor"
                     /protein_id="WP_006427088.1"
                     /transl_table=11
                     /translation="MQGLIGPLKELAEFEELCKNKKKDVGMIRVCGCVNSQKSHMMYAL
                     GDGCKYKVIACSSETKAKQIYEEYRFLDSNTYLYPAKDFLFYQADIRSKELVKQRMEGI
                     QAVLSGEPVTVVTSLDGFMDHLAPKESIAEKVLKVQNDSVLKLDEMAEKLSVIGYDREV
                     QVEGPGQFAVRGGILDIYPLTEELPVRIELWGDEVDSIRTFDVESQRSIENLMDIVIYP
                     AVEFPQNGEKGVSFLDYFPPEDTILFLDEPVRLVERGQNIEDEFMEAQKKRLESGYDLE
                     EEEAKIFPVTEILKKINCYSSIGFYALGMKCKGLEVRESYEIQAKSVNPYNNSFEMLTQ
                     DLKRLKRNGYRVILLSGSRTRAKRLAEDLRDYNLSSYYSEDLDREVKPGEIMTAYGYIA
                     EGYEYPMLKFTVIAESDIFGKRKKKKKRKTYEGRKIQSFSELKPGDYVVHENHGVGVYQ
                     GIEKIVVDKISKDYMKISYAQGGNLYIPATQLDLIQKYASADAKKPKLNKLGTQEWNRT
                     KTKVRGAVKEIARDLVKLYAARQEQDGYVYGEDTVWQREFEEMFPFEETEDQMMAIEAV
                     KKDMESHKIMDRLVCGDVGFGKTEVAIRAAFKAVQESKQVVYLVPTTILAQQHYRTFVQ
                     RMKDFPVRIDLMCRFRTPAQQKKTVEDAKKGLVDIIIGTHRVLSEDMKFKDLGLLIIDE
                     EQRFGVQHKEKIKKLKENVDVLTLTATPIPRTLHMSLIGIRDMSVLEEAPNDRMPIQTY
                     VMEYNDEMVREAIERECARQGQVYYVYNRVEDIDEVAGHVQKLVPDLTVAYAHGQMREH
                     ELERIMYDFINGEIDVLVSTTIIETGLDISNANTMIIHDADRLGLSQLYQLRGRVGRSN
                     RMAYAFLLYRRDKMLKEVAEKRLAAIREFTDLGSGFKIAMRDLEIRGAGNLLGAEQHGH
                     MEAVGYDLYCKMLNEAVKQLKGEMEEEETFTTTMDLNVDAFIPASYIPNEYQKLDVYKR
                     IAAIENREEMEDMTEELIDRFGDIPKKVEKLLEVAALKAQAHQLYVTAVEQKGEVYTFT
                     MYEKAKVHPERIPKLIEDFRGELTFKADGVQPCFIYEKKRRNLKEKQTDALESTKNVLN
                     GLKRLIGEEKSGIIDPLSK"
     gene            7141..8184
                     /locus_tag="I2E58_RS11170"
     CDS             7141..8184
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427087.1"
                     /locus_tag="I2E58_RS11170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_022415001.1"
                     /transl_table=11
                     /translation="MKKRALILALAGIMAASLIGCGSLKDDAVVVKAGDEEITAGVANF
                     YARYTQAQYETYFASYLGGDDMWSRNASDGKTYEESIKKTLLDDLKNMALLEEHMKDYD
                     VKLTKADKKAINDAAKEFDKANSQKKKDKVSGSKENVKRVMTLMAIEQKMRAAIVADAN
                     VKVTDEEATQKHMQYVEFDYSTTSDSSSSSDTTVSEAEKKKTKETAEAFAKGAKTAEDF
                     AAYATEQGTEAKDATFDSDSVSPSKEVVKAADKLGEGETTDVIEGDTACYVAKVTSLND
                     KTATETKKQSMITDKQDKYYKKVLKKWKKEEKITVHKGSWNKISFTKLSVKAKDTSTTG
                     TNSTSGN"
     gene            complement(8326..8772)
                     /locus_tag="I2E58_RS11175"
     CDS             complement(8326..8772)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006442056.1"
                     /locus_tag="I2E58_RS11175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GatB/YqeY domain-containing protein"
                     /protein_id="WP_006427086.1"
                     /transl_table=11
                     /translation="MSKIDEVRADMVKAMKAKDKDTKETLSMLLAALKNKAIDKREDLT
                     PEEETQVILKEIKQTKETLDMTPADRTEIIEECNKRLAVLEQYAPKMMDEAEIKEVVAS
                     VLAEMGLDAPTAKDKGKIMKNLMPKVKGKADGKLVNEIVSTFMK"
     gene            8933..9478
                     /locus_tag="I2E58_RS11180"
     CDS             8933..9478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016293831.1"
                     /locus_tag="I2E58_RS11180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="stage V sporulation T C-terminal
                     domain-containing protein"
                     /protein_id="WP_006427085.1"
                     /transl_table=11
                     /translation="MKATGIVRRIDDLGRVVVPKEIRRTLRIREGDPLEIFTDREGEII
                     LKKYSPIGELSAFAKQYAESLSQVLECLVGICDMDQVVAAAGNGKKEIQDEDITGELGE
                     FLKERKTRNAKAGEKRYVPIVSVSEPYKQEVISPILCAGDVIGAVFLLNQERTDRFKDT
                     ELCLAEYTAKVLGKQMEQ"
     gene            9553..9927
                     /locus_tag="I2E58_RS11185"
     CDS             9553..9927
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009262925.1"
                     /locus_tag="I2E58_RS11185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04086 family membrane protein"
                     /protein_id="WP_022415002.1"
                     /transl_table=11
                     /translation="MGKKGQNEVWIMWILKSLLAAYVVTGILLMILAMALYKFELTEEA
                     VTAGITAVYLLSTFAGGLVAGKLAKIRRFFWGIVLGILYFAFLLLITWGIYRTFHGSGT
                     EILMTFALCAGGGMAGGMIS"
     gene            10001..10141
                     /gene="scfA"
                     /locus_tag="I2E58_RS11190"
     CDS             10001..10141
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004605085.1"
                     /locus_tag="I2E58_RS11190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_022415003.1"
                     /sec_met_domain="TIGR03973 (E-value: 5.6e-24, bitscore:
                     76.2, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1e-23, bitscore: 75.4,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHVKSLNKPMNSNLKKSGCGECQTSCQSACKTSCTVGNQTCEQS
                     K"
     misc_feature    complement(10217..10231)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 19.82"
                     /tool="antismash"
     misc_feature    10252..10261
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     aSDomain        10354..10686
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I2E58_RS11195_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="1.80E-30"
                     /identifier="RREFam024.1"
                     /label="I2E58_RS11195"
                     /locus_tag="I2E58_RS11195"
                     /protein_end="111"
                     /protein_start="0"
                     /score="96.0"
                     /tool="antismash"
                     /translation="MIHQYRNNGYNIVMDVYSGSVHVVDDVCYDVIAEVNKSETEPTAE
                     SLKEADVKEKLLQTLGNKYETSDIEDALSDVIELTEGGQLFVKDTYECMIEEVKKRKTV
                     VKALCLH"
     gene            10354..11751
                     /gene="scfB"
                     /locus_tag="I2E58_RS11195"
     CDS             10354..11751
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427083.1"
                     /locus_tag="I2E58_RS11195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_022415004.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 5.4e-30,
                     bitscore: 96.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 9.1e-79, bitscore:
                     257.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.9e-17, bitscore: 56.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9.6e-15, bitscore: 47.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.4e-20, bitscore:
                     64.0, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYRNNGYNIVMDVYSGSVHVVDDVCYDVIAEVNKSETEPTAE
                     SLKEADVKEKLLQTLGNKYETSDIEDALSDVIELTEGGQLFVKDTYECMIEEVKKRKTV
                     VKALCLHIAHDCNLACKYCFAEEGEYHGRRALMSYEVGKKALDFLIKNSGNRRNLEVDF
                     FGGEPLMNWQVVKDLVAYGREQEKIHNKHFRFTITTNGVLLNDEIQEFVNKEMDNVVLS
                     LDGRKEINDQMRPFRNGKGSYDLIVPKFQKLAESRNQEKYYIRGTFTRNNLDFSNDIMH
                     FADLGFKQMSIEPVVGDESDPYAIREEDLPKIREEYDKLAKMMIEREKEGKGFNFFHFM
                     IDLNGGPCVAKRLSGCGSGTEYLAVTPWGDLYPCHQFVGQDDFLMGNVDDGIVKPEIAD
                     DFRSCNVYSKDKCRNCFAKFYCSGGCMANSYNFHGTIHDTYEIGCEMQRKRVECAIMMK
                     AALADEE"
     gene            11779..13944
                     /gene="secD"
                     /locus_tag="I2E58_RS11200"
     CDS             11779..13944
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427082.1"
                     /locus_tag="I2E58_RS11200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_195464977.1"
                     /transl_table=11
                     /translation="MKKSKSILSLLLAVILIVGLGFTVITGIGKSKSGAMKNIKLGLDL
                     AGGVSITYQVKDKNPTKEEMSDTIYKLQKRVEQYSTEASVYQEGNDRINIEIPGVTDAN
                     KILDELGKPGSLSFQTADGETVLTGTDVKSASAKTGQDNMGNKEYSVELNLTKSGTSKF
                     ATATKENIGKQIAIIYDGETISSPVVRSEITGGQAYITGDFTYEEADNLASTIRIGGLK
                     LQLEELRSNVVGAQLGEQALNTSLKAGIIGLILVFLFMIFVYRLPGLASSLALVIYTEI
                     VLVILNAFDVTLTLPGIAGIILSIGMAVDANVIIFARVREEMARGRSVKVSLKSGFQKA
                     MSAIVDGNVTTLIAAAVLWFKGSGTVKGFAQTLAIGIVVSMFTALVITRMIVFAFYGIG
                     IRKESLYYHKMKERKPINFLGKKKVFFSISIAMILAGFVVMGVHSAQGNGALAYSLDFK
                     GGTSMNVKFDKDYSIDEIDKEIVPVVEKVTGDHNIQTQKVSGTKQVVIKTVTLSLSERE
                     KVNKALEDNFGVKESDITAENISSTISNEMRQDAVIAVIVATIFMLLYIWFRFKDVRFA
                     TSAVLALLHDVLVVLAFYAVSRISVGGTFIACMLTIVGYSINATIVIFDRIREELPLMK
                     RNTDLSELVNKCITQTLTRSIYTSLTTFIMVAVLFIMGVSSIREFAAPLMVGIVCGGYS
                     SVCVTGALWYVMKTEVGKKAQPKKKKK"
     gene            14054..15814
                     /gene="recJ"
                     /locus_tag="I2E58_RS11205"
     CDS             14054..15814
                     /GO_function="GO:0008297 - single-stranded DNA
                     exodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440042.1"
                     /locus_tag="I2E58_RS11205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="WP_006427081.1"
                     /transl_table=11
                     /translation="MERWVLLRKGADFEAIGKKYQISPRLACLIRNRDVIGEEAIERYL
                     NGTISDLYDGMLMKDADKAIDILKEKIAEEKKIRVIGDYDIDGVNATYILLEGLERLGA
                     YVDSDIPDRIGDGYGLNRHLIDRAYDAGIDTIITCDNGIAAANEIAYGKELGMTIIVTD
                     HHEIPFDEIDGEKIYRLPPADAVIDPKQKDCVYPFKGLCGAAVAYKLMEALWESMGKDS
                     TDLDDLIENVAIATVGDVMDLEDENRIFVKEGLQMLKRTKNPGLKALIECTGIDKESLN
                     SYHIGFVLGPCINASGRLDTAKRALKLLRVRTQKEADILAGDLKALNDSRKDMTEEAVK
                     LAKEQVETTDLSDDRVLVIYLPDCHESLAGIVAGRIRECYYKPVFVLTDAEDGAKGSGR
                     SIDGYHMYEELNKCKDILTKFGGHRLAAGLSLEKENIAEFRRRLNENCTLTEEEMKEKV
                     TIDMEMPFLCVTEELVKELELLEPFGKGNTKPIFAARGVTLLGARILGKNRNVLKIKAQ
                     DANGSVIEAMLFQNVEGFLKNMEETYGRMEVDALLQGRGGHIKIAVTYYPDINEYMGKR
                     TPQIVITHYR"
     gene            15915..16439
                     /locus_tag="I2E58_RS11210"
     CDS             15915..16439
                     /EC_number="2.4.2.7"
                     /GO_function="GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006168 - adenine salvage [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427080.1"
                     /locus_tag="I2E58_RS11210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="WP_022415006.1"
                     /transl_table=11
                     /translation="MKPIEEYVRSIPDFPEPGIIFRDVTSILQDADGLHLAIDLMQEKL
                     KDVDFDVVVGPESRGFIFGVPIAYNLHKPFIPIRKKGKLPCETVSVEYELEYGTATIEM
                     HKDAIKPGQKVVIIDDLIATGGTNEAMVKMIESLGGEVVKAVFLMELAGLKGRERLEGY
                     DVDAVITYPGK"
     gene            16472..18817
                     /locus_tag="I2E58_RS11215"
     CDS             16472..18817
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009248621.1"
                     /locus_tag="I2E58_RS11215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_006427079.1"
                     /transl_table=11
                     /translation="MSDKTTYESLDNRIAPEALTEDHTKGLAVVDGHAVKSQEDYEDPN
                     RLYDMLIARIRKYHPSTDVSMIEKAYKLAVKAHGDQRRKSGEPYIIHPLWVAIILADLE
                     MDKETIAAGMLHDVVEDTKFTEEDIRREFGDEVALLVDGVTKLGRLSYSSDKLEVQAEN
                     LRKMFLAMAKDIRVIIIKLADRLHNMRTLQFMTPAKQKEKAKETMDIYAPIAQRLGISK
                     IKTELDDLALKYSQPEVFYDLVNQINARKTEREEFVEQIVEEVSTHMKNANIKAEVNGR
                     VKHFFSIYKKMVNQDKTVDQIYDLFAVRIIVESVKDCYAALGVIHEMYTPIPGRFKDYI
                     AMPKPNMYQSLHTTLMSSVGQPFEIQIRTEEMHKTAEYGIAAHWKYKESNDGKKSVEAQ
                     EEEKLSWLRQILEWQRDMSDNREFLNLIKGDLDLFAEDVYCFTPQGDVKNLPNGSTPID
                     FAYAIHSAVGNKMVGARVNGKLVNIDYKIQNGDRIEILTSQNSKGPSRDWLNIVKSTQA
                     KNKINQWFKKEFKESNIIRGKDMIATYCRAKSINVANIIQPKYQEIVQKKYGFKDWDSV
                     LAAIGHGGLKEGQVVNRLAEEYGKDHRQAITDEVVLERVAEAAKNKVHIAKSKSGIVVK
                     GIDDMAVRFSRCCNPVPGDEIVGFVTRGRGLSIHRTDCINMIHLSESERARLIPAEWET
                     EVTEKSGGQYLAEIKMYANDQQGLLMEISRIFTEGNVDVKSMNVRTSKKGTATIEMGFI
                     VHGREELERIVKKLQQLSGIIDIERATG"
     gene            18822..19445
                     /locus_tag="I2E58_RS11220"
     CDS             18822..19445
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004605091.1"
                     /locus_tag="I2E58_RS11220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_006427078.1"
                     /transl_table=11
                     /translation="MKIEKYVVGMIGTNCYLVINEETKDTVMVDPGAYPAKLKNAVKEQ
                     GLKLKAVLLTHAHFDHIMGLSDVMEDIKVPVYVEEADLPMMMDGESNLSSGYMRGGYQF
                     ADAVPVRDGQQLQIAGFQFRVIHTPGHTPGGCCYYMEQEDVLFSGDTLFRTSVGRSDFP
                     GGSASALVRSVKEKLLILPEETHVYPGHMEETTIGYEKRHNPFV"
     gene            19493..20998
                     /gene="hemZ"
                     /locus_tag="I2E58_RS11225"
     CDS             19493..20998
                     /EC_number="1.3.98.3"
                     /GO_function="GO:0051989 - coproporphyrinogen dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427077.1"
                     /locus_tag="I2E58_RS11225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="coproporphyrinogen dehydrogenase HemZ"
                     /protein_id="WP_195464979.1"
                     /sec_met_domain="PF04055 (E-value: 6.9e-22, bitscore: 71.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQIICKSESYTYNAYHILKAFYPSQEVSCKTDEKASNYVMVHLP
                     DDREISVGFENTVEITDTADRDESTGKIQEDSEKESQKKERKRQIDLSLYDQLERITGE
                     PLAWGVLTGVRPTKLAMQKLEAGWKKEDYINWAWESARVRGEKAALAWEIAEREQKILK
                     ELDYENGYSLYVGIPFCPSVCSYCSFSSGPLDRWKEKVDAYVDALCKELEFIAERSKNK
                     KLNTIYIGGGTPTTLTAEQLERLMSWIDEKFSREYLLEYTVEAGRPDSITEEKLKVIKN
                     HDITRISINPQSMQQKTLDVIGRKHTVEEIKEAYALARKTGFDNINMDIIAGLPGEDIS
                     DMEDTLAQIAQMHPDSLTVHSLAIKRAARMEMEDLNRDAKETHEILSGMIERAAKAAKE
                     MDLFPYYLYRQKNIAGNFENVGYAKVDKAGIYNILIMEEKQSIIAAGAGASTKIVLKDP
                     IPMPGSKKKKMTRLIRQENVKAVDAYIDRIDEMIERKGEWLWH"
     misc_feature    complement(21207..21225)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.5"
                     /tool="antismash"
ORIGIN
        1 gtgtgaggcc ggacgtatca ggcatcactt gaaacataat ctgtggcggc cggaatgtac
       61 catctgtttt gttggatatc aggcagtggg aacgcttgga agaaagctga tcgaaggtgc
      121 acagagtgtg aaattatttg gtgagaacat cacggtcaac gcaaagatag aagtgttaag
      181 gggaatcagc ggacatgcag atatgaatgg actgttagac tggctcgcag gatttgaaaa
      241 ggtaccggac cgtgtgatgg ttgtacatgg tgaggataca gtgacggatc attttgctgc
      301 gcttgtagaa gagcaatttg gctgcccggc atttgcaccg tattccggag gttccgtaga
      361 tcttgcgaca aatgagatca ttaccattgg tcagaagatt ccgaagaagg cagaagaaaa
      421 gccgaataag attaaaagtg catctgcatt taaccgtctg gtggcagcag ccaaacgtct
      481 gttaaatgta gtatataaga acgaaggaat tgccaataaa gatatggcaa aatttgaaac
      541 acagatccaa aatctggcag acaaatggga cagataaccg acgtcagacc ggatgtcaag
      601 gagtaaaagt ttttttaatt tcataagaat ccgcataagc ctgtgcgata tggagaatca
      661 ttttactaga aactgataga gaagattctg acaggaggtt cgcaatggca cagggaaaag
      721 tagaaatatg tggtgtgaat acagcaaagc ttccgatcct gaatgaaaag gagaaggaag
      781 ctttgtttgt gcgtattaaa gcgggagatc aggaagcgaa agaagaatat atcaaaggta
      841 atctaagact tgtcttaagt gtaataagga ggttcggtgc aagtggagag aatccggatg
      901 atctgttcca gattggctgt attggcctta ttaaagcaat caataatttt aatacagaat
      961 tagaggtaaa attttccact tatgcagtac ctatgattat cggagaaatc agaaggtaca
     1021 tgagagataa taattccata agagtcagcc ggtcactcag agacactgca tacaaggcaa
     1081 tttatgctaa ggaaaactat atgaagaaga atcagaaaga gcctacagta caggaaatcg
     1141 ctgaggagat cggaatatcc aaagaagata ttgtatttgc actggatgca atccaggtac
     1201 ctatgagcct tcaggaaccg gtgtacaatg atggaggaga tgcactctat gtaatggatc
     1261 agttaagtga tcagacgaat aaagaagaaa agtggataga agatttatca ttggaagaag
     1321 caatgaaaca tctgggagag agggaacggt atattataaa gcttcggttt tttcagggaa
     1381 aaacacagat ggaggttgca gatgaaatac agatatcaca ggctcaggtg agcagacttg
     1441 aaaagaatgc gttgaaaaca atgcgccagt accttatcta agggctggcg tatcgctttg
     1501 tgtgtcatgt atatgacaaa aaagtctgat agattttttt agtattgcat ttttgacagt
     1561 ctcatactat gatatttgca ggagggattt gtataatgaa agcttgtata tttgacctgg
     1621 atggaacatt aacaaataca ttggaatcta tgacatattc tgtgaatctg acactgaagg
     1681 agatggggct ctcccagatc acaaaggatc agtgcagaat gtttgtcgga aacggagcaa
     1741 gagttctgat cgaagaatct ctgaaagtgt cgggggatcc taaggcttca agaattgaag
     1801 aaggaatgaa aatttacgga cgtatatttg atcagaattg tacatatcat gtaacacttt
     1861 acgaggggat tccagagatg ttaaaagcat tgaaagacag aggaatccat ctggcagtcc
     1921 tttcgaataa gccggaccgt cagacggtaa aggttgtaaa agaaatcttt ggagataaca
     1981 tttttgacta tgcacaggga caaaaagacg gcatccgcag aaaaccagaa ccggacggag
     2041 tctggtatct gatggagcag atgcaggtat cgaaagaaga atgtctgtat atcggagatt
     2101 cggaagtcga tgcggcaacc ggaaagaatg caggccttaa gacaataggt gtgctgtggg
     2161 gattccggga caggaaaacg ttagaaactg cgggagcaga tcatctgatt gaaagaccgg
     2221 aagaactgtt gcagtttgtg taatattacg ataagggagg ttgagatgta tgtacgaata
     2281 tgatgaagaa tgtctgaaga cctttatcct gaaccaggga cagctgtttg acgaaccagt
     2341 tgctgagact ttagaagagg ctgaggcttt tctggaggat tgtatggctt ctatcgtaga
     2401 cagcattgaa gaagttaaag aattcctgga tcaggaggga atggatatca gcggaatgtc
     2461 tgatgaagag atcgaagagg catcggaagt atttgcactt ccagatggac gttatcttat
     2521 cgttgagggt taagatcaga acaagaacaa aagagagcaa aagaaaaagc cgcgactact
     2581 ttgtagtttc ggcttttttt agtgcgcttt caatggcctg aacaatcaac tgggaagtat
     2641 aaggagtatc ggaagaatac tgtatattct caagagactg ttttttatag acctgttcgg
     2701 caatatcttc aatcgccggt tcgataaaag ggtacatggt tgtgatggaa tcattcagat
     2761 tcgtaaaacg gattgaattg atatgcgttt catccactgt gacctcaact tctaaagcag
     2821 tattattcaa cgtaatatcg gaagtgtaga ttccgggagt gtagatcttc ttatcattgg
     2881 atccggaatg gtgtccggga cggaacatga atatcaaaag caggatcaga acaatggcta
     2941 atactgcaaa aataacggta tagatgattt ccttcatgtg aagtacaaca attttggttt
     3001 tggaactcat agcgagacct cctggtattt tatttcaaag attgttttat tttctataat
     3061 gtatgaaaaa agtggaagga ttattcattt aatttttccg tgacaaatgg gaaaggttct
     3121 tgtagaatgg taaaagaaat ggaaggtgaa gaattatgtt tattattgca ggacttggga
     3181 atcctacact tcagtatgaa ggaaccagac acaatgtagg atttgatgtc atagatatgc
     3241 tggcggacag atataatatt tctgtagatg gaagaaaagg aagagcgctg gtcggaaagg
     3301 gaatcattga gggtcagaaa gtgcttctgg taaaaccgca gacttacatg aatctcagcg
     3361 gggaaagctt aagagaactg gtcaattatt ataagatcga tgaagaacat gaacttctgg
     3421 tgatctatga tgatatcagt ttggatgtgg gacagctaag gatccgtaaa aaaggaagtg
     3481 ccggagggca taacggaatc aagaatatca ttgccaatct gggaacggat gtatttccga
     3541 gaatcaagat cggggtaggt gagaagccga agaaatatga cctggcggat tatgtgctgg
     3601 gacatttttc aaaagaagac cgtgaattga tggaagaagg ttatgaccgc gcagaccatg
     3661 cggtgggaat gatcttaaat ggagagatcg aggctgccat gaatcagtat aacaggaaag
     3721 taaagcctaa ggaggcataa aagatgcagg gcttaatcgg gccgttaaaa gaactggcag
     3781 agtttgaaga actctgcaag aataagaaaa aagatgtggg aatgatccgt gtgtgcggat
     3841 gtgtgaattc ccagaaatct catatgatgt atgcacttgg cgatggctgt aaatataaag
     3901 tcatcgcctg ttccagtgag acaaaagcaa aacaaatcta tgaagaatac cgtttcctgg
     3961 acagtaatac gtatctgtat ccggcgaaag attttctctt ctatcaggca gatatccgaa
     4021 gtaaagaact ggtaaagcag agaatggaag gaatccaggc agtgctttcg ggtgaaccgg
     4081 taacggttgt gacaagcctg gacggcttca tggatcatct ggcaccgaag gaaagtattg
     4141 cggaaaaagt acttaaggta caaaatgaca gcgttctcaa attggatgag atggcagaga
     4201 agctttcggt tataggttat gaccgggaag tgcaggtgga aggacctgga cagtttgcgg
     4261 tacgtggagg aatcctggat atctatccgc tgacggaaga acttccggtg cgtatcgaac
     4321 tctggggaga tgaggtggat tccatccgta cgtttgatgt ggagagccag cggtcgatcg
     4381 aaaatctgat ggatattgta atctatccgg cggtagaatt cccacagaat ggtgagaagg
     4441 gtgtctcgtt tctggattat tttccaccgg aggatacgat cctttttctg gatgaaccgg
     4501 tacgtcttgt ggagcgtgga cagaatattg aagatgaatt catggaagca cagaagaaac
     4561 gtctggaaag cggatatgat ttggaagagg aagaagcaaa aatctttccg gtcactgaga
     4621 tcctgaaaaa gatcaattgt tacagtagta tcggattcta tgcactgggg atgaaatgca
     4681 aaggactgga agtgagagag tcttatgaga tccaggcgaa aagtgtgaat ccgtataata
     4741 acagttttga aatgctgaca caggatctga aacggttaaa aagaaatgga tacagggtaa
     4801 ttctgttgtc aggttccagg acccgtgcga agcgtctggc ggaagattta agagattata
     4861 atctgagcag ttattacagt gaagatctgg accgggaagt gaagccggga gagatcatga
     4921 cggcatacgg atatatcgca gaaggttatg aatatccgat gctcaaattc actgtgatcg
     4981 cagagtcgga cattttcggc aaacggaaaa agaagaaaaa gagaaagaca tatgaaggcc
     5041 gtaagatcca gagcttttcg gaactgaaac cgggagacta tgtggtccat gagaatcatg
     5101 gtgtcggggt ctatcagggg atcgagaaga tcgtcgtaga caagatttcg aaggattata
     5161 tgaagatttc gtatgcacag ggcggaaatc tttatatccc ggcaacacag ctggatctga
     5221 tccagaaata tgcaagtgcc gatgccaaga aaccgaaact gaacaagttg ggaacgcagg
     5281 aatggaaccg gaccaagaca aaggtgcgcg gtgcggtaaa agagattgca agggatctgg
     5341 tgaagctgta tgcggcgaga caggaacagg atggttatgt ctatggagaa gatactgtct
     5401 ggcagcggga atttgaagag atgttcccgt ttgaagagac agaagaccag atgatggcga
     5461 tcgaggctgt gaaaaaagat atggaaagcc acaagatcat ggaccgtctg gtctgtggcg
     5521 atgtcggatt cggaaaaaca gaagttgcga tccgtgcggc attcaaagca gtacaggaga
     5581 gtaaacaggt ggtctatctg gttccgacaa caatccttgc acagcagcat taccggacgt
     5641 tcgtgcagcg tatgaaagac tttccggtgc ggatcgatct gatgtgcaga ttccgcacgc
     5701 cggcgcagca gaagaagaca gtcgaggatg cgaaaaaggg gctggtagat attatcatcg
     5761 gaacacaccg agtgttaagt gaagatatga aattcaagga tctcgggctt ctgatcattg
     5821 atgaagagca gagattcgga gtacagcaca aagagaagat caagaaatta aaggaaaatg
     5881 tagatgtact gacgcttacg gcaactccga tcccgagaac ccttcatatg agcctgatcg
     5941 gaatccgtga catgagtgtg ctggaagaag cgccgaacga ccgtatgccg atccagacgt
     6001 atgtcatgga atataacgat gagatggtac gtgaggcaat tgaacgggaa tgcgcaagac
     6061 agggacaggt atattatgtc tacaaccgcg tggaagatat tgatgaagtg gcaggacatg
     6121 tgcagaaact ggtgccggat cttacggttg cctatgcaca cggacagatg cgggaacacg
     6181 aactggaacg gattatgtat gatttcatta atggtgagat tgatgtactg gtatctacaa
     6241 cgatcataga gaccggactg gatatttcca atgcgaatac gatgatcatc cacgatgcgg
     6301 atcgtctcgg cctttcacag ctttatcagc tgcgtgggcg tgtcggacgc tctaaccgca
     6361 tggcatatgc attccttcta taccggagag acaagatgtt aaaagaagtg gctgaaaaga
     6421 gactggcggc catccgcgag tttacggatc ttggttcggg attcaagatc gcaatgcggg
     6481 atcttgagat ccgcggagca ggcaatcttc taggagcaga acagcatgga catatggaag
     6541 cagtcggata tgacctttac tgtaagatgc tgaacgaggc ggtgaagcag ctgaaaggcg
     6601 agatggaaga agaggagaca tttacaacga cgatggatct gaatgtggat gcatttattc
     6661 cggcttcgta tattccgaat gaatatcaga aactggatgt ttataaacgg atcgctgcaa
     6721 tcgagaacag agaagagatg gaagatatga cagaagaact gatcgaccgt ttcggagata
     6781 ttccgaagaa agtagaaaag cttctggaag tagcggctct gaaggcgcag gcacatcagt
     6841 tgtatgtaac ggcggtcgag cagaaaggcg aggtttacac atttaccatg tatgaaaaag
     6901 caaaagtaca tccggagcgg attccgaagc tgattgaaga ttttcgtggc gagctgacgt
     6961 tcaaagcgga tggggtgcag ccatgcttta tctatgagaa gaagagaagg aatctgaaag
     7021 agaagcagac agacgcattg gaaagtacaa aaaatgtgtt aaatgggttg aaaagattga
     7081 taggcgaaga aaaaagcggt ataattgacc cattaagcaa ataaaggcag gttaggataa
     7141 atgaaaaaaa gagcattaat attagcactg gcaggaatta tggcagcatc acttatcgga
     7201 tgtggatcac tgaaggacga tgcagtagtc gtaaaagcag gggatgaaga gatcacggca
     7261 ggtgttgcaa atttctatgc aagatataca caggctcagt atgaaacata ctttgcaagc
     7321 tatctcggcg gtgatgatat gtggagcaga aatgcatcag atggcaagac atatgaagag
     7381 tctatcaaga agacacttct ggatgatctg aagaatatgg ctcttctgga agaacatatg
     7441 aaagattatg atgtgaagct tacaaaggcc gataaaaaag caatcaatga tgcagcaaaa
     7501 gaatttgaca aagccaattc acagaagaaa aaagacaagg tgtccggttc taaggaaaat
     7561 gtaaaacgtg tcatgacact gatggcgatc gaacagaaaa tgcgtgcggc aattgtagca
     7621 gatgcgaatg tgaaagtaac ggatgaagaa gcgacacaga agcatatgca gtatgtagaa
     7681 tttgattata gtacaacatc tgattcttca agctcatcag atactacagt atccgaagcg
     7741 gaaaagaaaa aaaccaaaga gacggcagag gcatttgcca aaggtgcaaa gacagcagaa
     7801 gattttgctg cgtatgcaac ggaacaggga acagaagcca aagatgccac gtttgattcg
     7861 gattcagtaa gtccgtctaa ggaagtcgta aaagcagcag acaaattagg agaaggcgag
     7921 acgacggatg tgatcgaagg tgacactgca tgctatgtgg caaaagttac aagcctcaat
     7981 gataaaacgg ctacagagac taagaaacag tccatgatca cagataaaca ggataaatac
     8041 tataaaaaag tattaaagaa atggaaaaaa gaagaaaaga ttacagtcca taaaggtagc
     8101 tggaataaga ttagctttac aaaactgagt gtgaaagcca aagacacaag tacaaccgga
     8161 acaaacagta cttctggtaa ctaagaggat taaaataatg ggcagcatcc atcgggtgct
     8221 gcccattatt ttgtgatcac tatgtgttcg gaagaagcag caggtggcgg ttctgtagat
     8281 accatagtat acaagaagag ctgccagcgg cagctcttga agattttatt tcatgaaagt
     8341 agatacgatc tcgttgacga gcttgccgtc agcttttccc tttactttag gcatcaggtt
     8401 cttcatgatc ttgcctttat cctttgcggt aggagcatcc agtcccatct ctgcaagaac
     8461 agaagcaacg acttctttga tctctgcttc atccatcatc ttaggagcat actgttccag
     8521 aacagccaga cgcttgttgc attcttcgat gatctctgta cgatctgcag gagtcatatc
     8581 cagggtctct tttgtctgct tgatctcttt taagattacc tgagtctctt cttccggtgt
     8641 caggtcttcg cgtttgtcga ttgctttatt cttaagagct gcaagcagca tggataaagt
     8701 ttcctttgtg tctttgtctt tggctttcat ggctttgacc atatcagcac gtacttcatc
     8761 aattttactc atgattcatt cctcctaata ttttcttcca actattatac aaaactattg
     8821 aaaaaatatc cagtctaata tctgcatgaa taattccttg ctgttttcag catactagcc
     8881 atatgttaga aaatatggaa aaaacagaaa aatcaggagg aagataaatg ctatgaaggc
     8941 aacaggaatc gtaagaagaa tcgatgatct ggggcgtgtg gtcgtgccaa aagagatcag
     9001 aaggacactg aggatcaggg aaggcgatcc gctggagata tttacagaca gagaaggtga
     9061 gattattctg aagaaatatt caccgatcgg ggaactgtct gcatttgcaa agcagtatgc
     9121 ggaaagtctg tcgcaggttc tggaatgcct ggtggggatc tgtgatatgg atcaggtagt
     9181 ggcagcagcg ggaaatggaa agaaagagat tcaggatgaa gatattacgg gagagcttgg
     9241 agaatttctg aaagaacgaa aaacacggaa tgccaaagcc ggggaaaaaa gatatgtacc
     9301 gatcgtgagt gtatcagaac cttataaaca ggaggtgatc agtccgattc tgtgtgcagg
     9361 tgatgtgatc ggtgcggttt ttctgctgaa tcaggaacgt acggacagat tcaaagatac
     9421 agagctttgt cttgcggaat atacggcaaa ggttctgggc aaacagatgg aacaatagga
     9481 cgattgtaaa caaaaataag cgcataaatc agatgcttcc ttcataatct gtgatagatg
     9541 aggagggaaa gcatgggaaa aaagggacaa aatgaagtgt ggatcatgtg gatactgaaa
     9601 tctcttctgg cagcatatgt agtgaccgga attcttttga tgatactggc aatggcgctg
     9661 tataaattcg aacttacgga agaagctgtg acagcaggga tcacagcggt ctatctgctc
     9721 tctacatttg ccggtggact tgtggcgggt aaacttgcaa agatcagacg tttcttttgg
     9781 ggaattgtac ttgggattct gtacttcgca tttctgttac tgattacatg gggaatctat
     9841 cgtacatttc acggaagtgg aacagagatt ctgatgacat ttgcgctgtg tgcgggaggt
     9901 ggtatggcag gcggaatgat atcctaagaa aaagattgcg aaacctatgt cgaaatgtta
     9961 taataacgta agttaagcaa tagtaaggag ggatacgaac atgaaacatg taaaatcatt
    10021 gaataaacct atgaacagca atctgaaaaa aagcggatgc ggcgaatgcc agacatcatg
    10081 ccagtcagca tgtaagacat cctgtacagt aggaaaccag acttgcgaac agagcaaata
    10141 atttaaaaag atatgggata cttgggacag cggtctttag ggtccgctgt ttcttgttgc
    10201 catgcatgtg acgaaaaggt ccggtggacc ttttttagtt gtctgcggaa ttgttttttg
    10261 attatttgac aacatatggt ttttgacggg tagaaagata acgggaaatt cccgatatga
    10321 aataagaaaa atgagaaagg ggtaccaaag gatatgattc atcagtaccg taataatgga
    10381 tataatatcg ttatggacgt gtacagcgga tctgtacatg tggtagatga tgtctgttat
    10441 gacgtgatcg cggaagtgaa caagtcagaa acagaaccaa ctgccgaatc gttaaaagaa
    10501 gcggatgtaa aagaaaagct tttacagaca cttggaaaca aatatgaaac atccgacatt
    10561 gaagatgcat tatcagacgt gatcgaactg acagaaggcg gtcagttatt tgtaaaagat
    10621 acatatgaat gcatgatcga agaagtaaag aagagaaaga cagttgtaaa ggcactgtgc
    10681 ctgcatattg cacacgactg taaccttgct tgcaaatact gttttgcaga agaaggggaa
    10741 tatcatggaa gacgagcact tatgagctat gaagtcggta agaaagcgct ggacttcctg
    10801 atcaagaatt ctggcaaccg ccgtaatctg gaagtagatt tcttcggcgg ggagcctctg
    10861 atgaactggc aggtggtaaa agatctggta gcttacggaa gagagcagga gaagatacat
    10921 aataagcatt tccgttttac aatcacaacg aacggagtgc tgttaaatga tgaaattcag
    10981 gaatttgtaa ataaagaaat ggacaatgta gtgttgagcc tggatggacg taaagagatc
    11041 aatgatcaga tgcgtccgtt tagaaatgga aaaggaagtt atgatctgat cgttccgaag
    11101 ttccagaaac ttgcagaaag cagaaatcag gaaaaatatt acattcgtgg cacatttaca
    11161 agaaataatc tggatttctc caatgatatc atgcattttg cagacctcgg attcaaacag
    11221 atgtcgattg aaccggttgt tggagatgaa agtgatccgt atgcgatcag ggaggaagat
    11281 cttcctaaga tcagggaaga atatgataag ctcgccaaga tgatgatcga acgcgagaaa
    11341 gaaggaaaag gcttcaattt cttccatttt atgatagatt taaatggtgg accatgtgtg
    11401 gcaaaacgtt tatccggttg tggatccgga acagagtatc tggctgttac accatgggga
    11461 gacctctatc catgccatca gtttgtcgga caggatgatt tcctgatggg taatgtggat
    11521 gatggaatcg tgaagccgga gattgctgac gatttcagaa gctgcaatgt gtattccaaa
    11581 gataaatgca gaaactgctt tgcaaaattc tactgtagcg gcggatgcat ggcaaactct
    11641 tataatttcc atggtacgat ccatgatact tatgagatcg gctgtgagat gcaaagaaaa
    11701 cgtgtagagt gtgcgatcat gatgaaggca gcacttgcag atgaagaata atatttcgag
    11761 aggatgtgta agagaacgat gaagaagtca aaaagcatac tgagtctgct tctggctgta
    11821 attctcatcg tcggacttgg atttactgtg atcacaggaa ttggcaaatc taagtccggt
    11881 gcgatgaaaa acatcaaact tggtctggat cttgccggtg gtgtaagtat tacctatcag
    11941 gtaaaagata agaatccgac caaagaagag atgagcgata cgatctacaa actgcaaaag
    12001 cgtgtagaac agtacagtac agaagcaagt gtataccagg aaggaaatga ccgtattaac
    12061 attgagatcc ctggtgttac agatgccaat aagattctgg atgaacttgg aaaaccaggt
    12121 tccctttcat tccagacagc ggatggagaa acagttctta cgggaacaga tgttaagagt
    12181 gcgtctgcga aaaccggtca ggataacatg gggaataaag aatattctgt agagttgaat
    12241 ctgaccaaat caggtaccag caaatttgca acggcaacga aagaaaatat cggaaaacag
    12301 attgcgatca tctatgatgg tgagacaatc tcaagtccgg tcgtacggtc tgagatcaca
    12361 ggtggacagg cctatattac aggcgacttc acttatgaag aagcagataa tctggcatct
    12421 acgatccgta tcggtggact gaaacttcag cttgaagagc tgcgttccaa tgtagtagga
    12481 gcacagcttg gagaacaggc attgaataca agtttaaaag ccggtattat tggtctgatc
    12541 cttgtattcc tgttcatgat ctttgtatac agacttccgg gactggcatc aagccttgcg
    12601 ctggtcatct atacagagat cgtacttgta atattgaatg cgtttgatgt aacgttgacc
    12661 cttccgggta ttgccggtat cattttaagt attggtatgg cagtagatgc gaatgttatc
    12721 atctttgccc gtgtacgtga agagatggca agaggaagaa gtgtaaaagt atccttaaaa
    12781 tcaggattcc agaaagctat gtcagcaatt gttgacggta atgtgacaac actgatcgcg
    12841 gctgcggttc tgtggtttaa aggttccgga acagtcaaag gatttgcgca gactctggca
    12901 atcggtattg tggtatcaat gtttacagca ctggtgatta cacgtatgat cgtgtttgcg
    12961 ttctatggaa tcggaatccg aaaagagagt ctgtattacc ataagatgaa agaaagaaag
    13021 ccaatcaact tccttggcaa gaagaaggtg ttcttcagta tttctattgc aatgatcctt
    13081 gcaggattcg tggttatggg agtacattct gcccagggta acggggcatt ggcttacagt
    13141 ctggatttca agggcggaac atctatgaat gtgaagtttg acaaagatta ttccatcgat
    13201 gagattgata aagagatcgt tcctgttgta gaaaaagtga caggagatca taatatccag
    13261 acacagaaag tatccggaac aaaacaggta gtcatcaaga cagtaacttt aagtctgtct
    13321 gaacgtgaga aggtaaataa ggcactggaa gataattttg gtgtaaaaga atctgatatc
    13381 acagcggaaa atatcagttc aacgatcagt aatgagatgc gtcaggatgc agtgatcgca
    13441 gtgatcgtgg caacaatttt catgttgctt tatatctggt tccgtttcaa agatgtacgt
    13501 tttgctacaa gtgcggtgct ggcattatta catgatgtgc tggttgtact ggcattctat
    13561 gcagtatcca gaatctcagt cggaggtaca tttattgctt gtatgctgac gattgtaggt
    13621 tattcgatca acgcgacgat cgtaatcttt gaccgtatcc gtgaggaact tccgcttatg
    13681 aagagaaata cagatctgtc agaacttgta aataagtgta ttacacagac actgacaaga
    13741 agtatttata cttcactgac aacatttatc atggttgcgg tactgtttat tatgggtgta
    13801 agttctattc gtgagtttgc agcacctctg atggtaggta tcgtctgcgg tggatattct
    13861 tctgtatgtg ttacaggagc actgtggtat gtaatgaaga cggaagtcgg caaaaaagca
    13921 cagccaaaga aaaagaaaaa atagatcata aaatgatccg ggaagcagtt atgcctattg
    13981 acagggcata actgcttttt ttaaaataga gacataatat tctgacggac agatacaaag
    14041 gggataaaga taaatggaac gatgggttct gctgcgcaaa ggtgcagatt ttgaagcgat
    14101 aggaaagaaa tatcagatta gtccgagact ggcatgcctg atccgcaaca gggatgtgat
    14161 cggagaagag gcaatcgaac gttatctgaa tggaacgatc agtgatctgt atgatgggat
    14221 gctgatgaaa gatgcggata aggcgattga cattttgaaa gaaaagattg cagaggagaa
    14281 gaaaatccgg gtgatcggag attatgatat tgatggtgtg aatgcgacgt atattttgct
    14341 ggaggggctg gaacgtctcg gggcatatgt ggacagtgat attccggacc gcataggtga
    14401 cggatatggt ctgaatcggc atctgatcga ccgggcttac gatgccggaa tcgatacgat
    14461 cattacctgt gataatggaa tcgcagcagc aaatgagatt gcatatggca aagaactggg
    14521 catgacgatc atcgtaacgg atcatcatga gatcccgttc gatgaaatag acggagaaaa
    14581 gatatacaga cttccaccag cggatgcagt gatcgatccg aagcagaagg actgtgtata
    14641 tccgtttaag ggactctgtg gcgcggcggt tgcatataaa ctgatggagg cgttgtggga
    14701 aagcatgggg aaagattcca ctgatctgga tgatctgatt gaaaatgttg caatcgcaac
    14761 ggtcggtgac gtgatggatc tggaggatga gaaccggatc tttgtcaaag aaggactgca
    14821 gatgcttaag cgaacgaaga atccgggact gaaagcactg atagaatgta caggaattga
    14881 taaagaaagt ctgaattctt atcatatagg gtttgttctg ggcccctgta tcaacgcaag
    14941 cgggaggctg gatacagcaa agcgggcact gaaacttctg cgggtgcgta cacagaaaga
    15001 agcggatatt cttgcgggtg atttaaaagc attaaatgac agcagaaagg atatgaccga
    15061 agaagcagta aagcttgcga aagaacaggt ggagacgaca gatttatccg acgacagggt
    15121 actggtcatc tatctgccgg attgtcatga aagccttgcg gggattgttg cgggaagaat
    15181 aagggaatgc tattacaaac cggtattcgt actgacggat gcagaggatg gtgcgaaagg
    15241 atccggacgg tcgatcgacg gatatcatat gtatgaggaa ctgaataaat gcaaagatat
    15301 cctgacgaag tttggcggac accggctggc agcaggactt tctctggaaa aagagaatat
    15361 cgcagaattc cggagaagac tgaatgagaa ctgcaccctg acggaagaag aaatgaaaga
    15421 aaaagtcacg attgatatgg agatgccgtt tctttgtgtg acggaagaac tggtgaaaga
    15481 gctggaactt ctggaaccat tcggaaaagg gaatacaaag ccgatatttg ccgcacgcgg
    15541 agtgacgctt ctgggagcga gaatacttgg aaagaacaga aatgtactga agataaaggc
    15601 gcaggatgca aacggaagtg tcatagaagc catgctgttc cagaatgtgg aaggattctt
    15661 aaagaatatg gaagagacct acgggcgcat ggaggtggat gctcttttac aaggcagagg
    15721 cggtcatata aaaattgcgg tgacttatta tcctgatatc aatgaatata tgggaaagag
    15781 aacaccgcag attgtgatca cacattaccg ttaagctggt ttctctcgtt gcagggtgaa
    15841 aaccatagat tgaaaatcag aacgagtaat ggtatactta aagttgtatt ttagacagaa
    15901 atggagagag tatcatgaaa ccgatagaag agtatgtaag aagtattccg gattttccgg
    15961 aaccgggaat tatattcaga gacgtaacaa gcatccttca ggatgcagat ggattacatc
    16021 tggcgataga cctgatgcag gaaaaattaa aagacgtgga ttttgatgtg gttgtaggac
    16081 cggaatcaag aggatttatc tttggtgtac cgatcgcata taatctgcac aagccattta
    16141 tcccaatcag aaaaaaagga aaactcccat gcgagacggt ttctgttgaa tatgaactgg
    16201 agtatggcac agccacgatc gagatgcaca aagatgcaat caagccgggg cagaaagtgg
    16261 ttattattga tgacctgatt gctacaggcg gaaccaacga ggctatggtg aagatgatcg
    16321 aaagcctcgg cggagaagtg gtaaaagcag tatttctgat ggaacttgcc gggttaaaag
    16381 gaagagaaag attagaagga tatgatgtgg acgctgtgat cacatatcct ggaaaataaa
    16441 aagagagaaa tcaagggaag gaggcgttaa tatgtctgat aagacaacct atgaatcact
    16501 ggacaaccgg atcgcaccgg aagcactgac agaagatcac acgaaagggc ttgcagttgt
    16561 agacgggcat gcggtaaaat ctcaggaaga ttatgaggac ccgaaccggt tatatgacat
    16621 gttaattgcc cgtatccgaa agtatcatcc gtccacagat gtttccatga ttgaaaaagc
    16681 ttataagctg gcggtaaagg cgcatggaga tcagcgcagg aaatccggag aaccatatat
    16741 catccatcct ttgtgggtag cgatcattct ggctgatctg gagatggata aagagacgat
    16801 tgcggcaggt atgctgcatg atgtggtaga agatacaaag tttacggaag aagatatccg
    16861 gagggaattt ggagatgagg tagcacttct ggtagatgga gttaccaaac tgggaagact
    16921 ctcttattca tcggataaac tggaggtaca ggcagaaaac ctgcgtaaga tgttccttgc
    16981 catggcgaag gatatccgtg tgatcattat caaactggca gaccgtctgc ataatatgcg
    17041 taccttgcag ttcatgacgc cggcaaagca gaaagaaaaa gcgaaagaga cgatggacat
    17101 ctatgcgccg atcgcacagc gtcttggtat atctaagatc aagacggaac tggatgacct
    17161 ggcacttaag tattcccagc cggaggtgtt ctatgacctg gtgaaccaga tcaatgcaag
    17221 aaagacagag agggaagaat tcgtagagca gatcgtagaa gaagtatcga cacatatgaa
    17281 gaatgcgaat atcaaagcag aggtcaacgg acgtgttaaa catttcttca gtatctataa
    17341 gaagatggtg aatcaggata agacggttga ccagatctat gatctgtttg ctgtgcgtat
    17401 catagtagaa tctgtaaaag actgttatgc ggcgctgggt gtgatccatg agatgtatac
    17461 gccgattccg ggacgtttta aagactatat tgctatgccg aagccgaata tgtaccagtc
    17521 actgcatacg acactgatga gttcggtcgg acagccgttc gagatccaga tccgtacaga
    17581 agagatgcat aagacagctg aatatggtat cgctgcacac tggaagtata aagaatccaa
    17641 tgatggtaag aagagtgtgg aggcacagga ggaagagaag ttaagctggc tgcgtcagat
    17701 cctggagtgg cagagagaca tgtcggataa cagagaattc ctgaacctga tcaaaggaga
    17761 tctggatctg tttgcagagg atgtctattg ctttactccg cagggagatg taaagaacct
    17821 gccgaatggt tcaactccga tcgattttgc ttatgcgatc cacagtgcgg tcggtaacaa
    17881 gatggtagga gccagagtca acggaaaact tgttaacatt gattataaga tccagaatgg
    17941 cgacagaatc gagatcctga catcccagaa ttccaaggga ccaagccgtg actggctgaa
    18001 tattgtaaag agtacccagg caaagaataa gatcaaccag tggttcaaga aagagttcaa
    18061 ggaaagcaat atcatccgcg gtaaggatat gattgcgacg tactgcagag cgaaaagtat
    18121 caatgttgca aatatcatcc agccgaaata tcaggagatt gttcagaaaa aatacggatt
    18181 caaagactgg gattctgtat tggcggcaat cggacatggc ggcttaaaag aaggccaggt
    18241 cgtgaatcgt cttgctgaag aatatggaaa agatcacaga caggcaatta ccgatgaagt
    18301 tgttctggag agagtggcag aagcagcgaa gaataaagta cacattgcca agtcaaagag
    18361 tggcattgtt gtcaagggaa ttgatgatat ggcagtccgt ttctccagat gctgtaaccc
    18421 ggtaccggga gatgagatcg tcggatttgt tacacgtgga agaggacttt ccattcaccg
    18481 aacggactgt atcaatatga tccacctgtc cgaatcggaa cgtgcaagac tgattcctgc
    18541 agagtgggag accgaagtga cggaaaaatc cggcggtcag tatcttgcag agatcaagat
    18601 gtatgcgaat gaccagcagg gacttctgat ggagatatcc cgaatcttta ctgagggaaa
    18661 cgtagatgtc aaatctatga atgtccgtac cagtaagaag ggaacggcaa cgatcgagat
    18721 gggattcatc gttcacggcc gtgaagaatt ggagcgcatc gtgaagaagc tgcagcagct
    18781 ttccggaatc atagatatag aaagggcaac aggctaaaag tatgaagata gaaaaatacg
    18841 tagtgggaat gatcggtacc aattgttatc tggtgatcaa tgaagagaca aaggatacgg
    18901 tcatggttga cccgggagca tatccggcaa aattaaagaa tgccgtgaaa gagcagggac
    18961 tgaagctgaa ggctgtactt ctgacacatg cacattttga tcatattatg ggactttccg
    19021 atgtgatgga agatataaaa gttccagtat atgtggaaga agcagatcta ccgatgatga
    19081 tggacggtga aagcaatctg tcttctggtt atatgcgcgg aggatatcag ttcgcagatg
    19141 cggttccggt cagagacgga cagcagcttc aaattgcagg ctttcagttc cgtgtgatcc
    19201 atacaccggg gcatacaccg ggcggatgct gctattatat ggaacaggaa gatgttcttt
    19261 ttagcggtga tacattgttc cgtacatccg tcggacgttc ggacttccca ggtggaagtg
    19321 catcagcact ggtccgttct gtaaaagaaa agcttttgat attaccggaa gagacgcatg
    19381 tatatccggg gcatatggaa gagacgacga ttggttatga aaagcgtcat aatccatttg
    19441 tataatgaac gataagaaaa gacagtgaaa gaaaacggaa tggagaaata gaatgattca
    19501 gattatatgt aaaagcgagt cttatactta taatgcgtat catatattaa aggcttttta
    19561 tccgtcacag gaagtatcct gtaagacgga tgaaaaagcc tctaattatg taatggtaca
    19621 tttgccggat gaccgtgaaa tttccgtggg atttgagaac accgtggaaa ttactgacac
    19681 agcagatcgg gatgaaagta cagggaagat acaggaagat tcagagaagg agagccagaa
    19741 aaaagaaaga aaacggcaga ttgatctgag cctgtatgat cagctggaaa ggattacagg
    19801 agagccgctt gcgtggggag tgcttacggg agtgcgcccg accaagcttg ctatgcagaa
    19861 actggaagcc ggatggaaaa aagaagatta tattaactgg gcatgggaaa gtgcgagagt
    19921 gagaggagaa aaagcagctc ttgcatggga gattgccgaa agagaacaga aaattttaaa
    19981 agaactggat tacgagaacg gatatagcct gtatgttgga atcccgttct gtccatcggt
    20041 ctgttcttac tgttctttca gttccggacc actggatcgc tggaaagaaa aagtggatgc
    20101 atatgtggat gcactttgca aagagctgga atttatcgca gaacgctcga aaaacaaaaa
    20161 attaaatacg atctacatcg gcggaggtac gccgacaacg ctgacggcag agcagctgga
    20221 acggctgatg agctggatcg atgagaagtt ttcgagagaa tacctgctgg aatatacagt
    20281 ggaagccgga agaccggaca gcattacaga agagaagttg aaagtcataa agaatcatga
    20341 cattacaaga atttccatta atccacagag tatgcagcag aagacgctgg atgtgattgg
    20401 aagaaaacat accgtagaag agataaaaga agcctatgca ctggccagaa agactggatt
    20461 cgataatatc aatatggata tcatcgcagg acttccggga gaagatattt ctgacatgga
    20521 agatacactg gcacagatcg cacagatgca tccggacagt ctgacagtgc attcactggc
    20581 gatcaaaaga gcagccagaa tggagatgga ggatttgaac cgggatgcga aagagacgca
    20641 tgagatcctt tccggcatga tcgagagggc tgcaaaggca gcaaaagaga tggatctttt
    20701 cccgtattat ctgtacagac agaagaatat tgcggggaat tttgaaaatg ttgggtatgc
    20761 aaaggttgac aaagccggaa tatacaatat acttattatg gaagaaaaac aatctattat
    20821 tgccgcagga gccggagcat cgacaaagat tgtattgaag gatccgattc ctatgccggg
    20881 cagtaaaaag aagaaaatga cgcgtctgat ccgtcaggag aatgtcaagg cggtagatgc
    20941 ctacatcgac aggatcgacg aaatgataga acgcaaagga gaatggttat ggcattaaag
    21001 aagaaaccgg ttaccggtat gaaagacatg ctcccacgtg agatggagat ccgtgattac
    21061 ctgatcggac tgatcaaaga gacgtataag acatacggat tctgttccat cgagacacca
    21121 tgtgtggaac atatcgagaa cctgtgcagc aaacagggcg gagacaacga gaaactgatc
    21181 ttcaagatct taaaaagagg agaaaaactg aagatcgata cagcaaaaga agaaaacgat
    21241 ctggtagacg gaggattgcg ttatgatctt accgtaccgc ttgccagata ttatgcaaac
    21301 cattcgaatg aattgccggc accttttaag gcattgcaga ttggtaatgt atggagagca
    21361 gaccgtccgc agaaaggacg tttcagacag ttcatgcagt gtgatattga tatcttagga
    21421 gagccaggaa atctcgcaga gatcgaactg atccttgcaa cgacagctat gcttggcaaa
    21481 ttaagcttcc agaactttac ggtatgtatc aatgaccgta atatcctgaa agcaatggct
    21541 gcttacagtg gtttccgtga ggatgattat gatgaagtct tcatcattct ggataagatg
    21601 gacaagatcg gtgcagaagg tgttgcaaaa gaattagaag agatgggata tgtaaaggaa
    21661 aatgtagaga cttatcttca gttatttaag gatgtagcac cagatgtaac aggtatccgt
    21721 ttcttgaaag aaaaactggg cgactgctta a
//
