LOCUS       NZ_JADNJR010000016     31649 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Dorea longicatena strain 1001136B_160425_G1
            NODE_16_length_82834_cov_66.212, whole genome shotgun sequence.
ACCESSION   NZ_JADNJR010000016
VERSION     NZ_JADNJR010000016.1
KEYWORDS    WGS; RefSeq.
SOURCE      Dorea longicatena
  ORGANISM  Dorea longicatena
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Dorea.
REFERENCE   1  (bases 1 to 82834)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 82834)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.58x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 03:07:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,053
            CDSs (total)                      :: 2,995
            Genes (coding)                    :: 2,936
            CDSs (with protein)               :: 2,936
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 10 of 59
            Pseudo Genes (incomplete)         :: 53 of 59
            Pseudo Genes (internal stop)      :: 5 of 59
            Pseudo Genes (multiple problems)  :: 7 of 59
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:58:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 51185
            Orig. end                         :: 82834
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADNJR010000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..31649
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..31649
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20742
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20742
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10742](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10742)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     gene            complement(678..1340)
                     /locus_tag="I2E58_RS10735"
     CDS             complement(678..1340)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015541031.1"
                     /locus_tag="I2E58_RS10735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_005359225.1"
                     /transl_table=11
                     /translation="MAKILAVDDEPAILEMIESILNKDGHLVTKVSNPLKINMEELHRY
                     DLILLDIMMPGIDGFELCKRIRILVDCPILFLTAKTEENSLVNGLSLGADDYISKPFGV
                     MELRARINAHLRREHREHSVRMVLGRVCIQISQKKLLVDDKELPLTKAEYEICEFLAKN
                     RGQVFSKEQILEAVFGFDNESNDSTIITHIKNIRAKFADYDYTPIKTVWGIGYKWEE"
     gene            complement(1355..2095)
                     /locus_tag="I2E58_RS10740"
     CDS             complement(1355..2095)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005330844.1"
                     /locus_tag="I2E58_RS10740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_005330844.1"
                     /transl_table=11
                     /translation="MIGRSLNADLRKMKGTSVILAHLLIPIITSVIFLIYYFFSPWNEN
                     MKVIAFYQAIGAGLPVLIGIFTASVMEQEQNAGDFQNLLSLPDKPAAFLSKLLMLLVLC
                     LCSILLTAIIFGIGFGRIASSDIEIMKGCIFAALLLWGSSVPLYLWQLILAFQFGKGVS
                     IGAGIISGLISALMLTGLGDYVWKYVFVCWTGRVPYTYLQSVLGETSVGEWLSFIPGCL
                     IFTGISMVYYFWWVNHWEGNRISE"
     gene            complement(2097..2828)
                     /locus_tag="I2E58_RS10745"
     CDS             complement(2097..2828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015541029.1"
                     /locus_tag="I2E58_RS10745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_004853398.1"
                     /transl_table=11
                     /translation="MVNIIKAEHQKAKRTMRKKFIWGFPLLTFVMAFIFTLGMTNAYAE
                     SVWNWWYTLLLPGMIALFCYLSVAQEKKIKYYHLMTIPTDRRKLLLGKIIYIGYMILFS
                     NVIVFAGATLGGFLLTTHVPVGGALIAVLFLTVSELWEIPVALFLSERFGMIVNLFVCL
                     FITVSGVVISQTRIWYVLVSAIPMRMMCPLLHVLPNGLAAEAGNPLLDTGVIVPGMCLS
                     IIWFVFVTVLFLKWFERREVK"
     gene            complement(2821..3534)
                     /locus_tag="I2E58_RS10750"
     CDS             complement(2821..3534)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005359230.1"
                     /locus_tag="I2E58_RS10750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_005609481.1"
                     /transl_table=11
                     /translation="MEMMLQTQNLCKYFRKQKAVNNVSLNIEKGQIYGLLGPNGAGKST
                     TLKMLTGMMKPTAGKIYFDGKLLDRKDLSKIGALIENPPIYENLSARENLKVRQLLLGT
                     DENRIDEVLQIVSLTNTGKKKAGQFSLGMKQRLGIAMALLGEPELLILDEPTNGLDPIG
                     IEELRELIRSFPEQGITVILSSHILSEVQLLADKVGIISGGILGYEGALKQGDNLEDLF
                     MNVVRKNQKAGEIHG"
     misc_feature    3639..3654
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.38"
                     /tool="antismash"
     misc_feature    3641..3655
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.93"
                     /tool="antismash"
     misc_feature    complement(3819..3832)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.91"
                     /tool="antismash"
     gene            complement(3891..4070)
                     /locus_tag="I2E58_RS10755"
     CDS             complement(3891..4070)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002594660.1"
                     /locus_tag="I2E58_RS10755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_195464940.1"
                     /transl_table=11
                     /translation="MREKAYHLYLNEEERSRVIQSLIELKNNLAAQGRYTDAVDDVLCK
                     VLEAKKKKLKIEYI"
     gene            complement(4067..5035)
                     /locus_tag="I2E58_RS10760"
     CDS             complement(4067..5035)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015512766.1"
                     /locus_tag="I2E58_RS10760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-ribbon domain-containing protein"
                     /protein_id="WP_195464950.1"
                     /transl_table=11
                     /translation="MNNSLAEVHPELITEWSEKNLPLTPDDITFGSNKKVWWKGACGHE
                     WQTSIKARSNGEKCPICSGARVIAGINDLQTTHPEIASEWSEKNLPLKPDEVNAKSRKN
                     VWWRCGKCGNEWKSVINARVKGTVCPVCAEREVLAGYNDLATTDNQLLSEWDYEQNKLK
                     PTEVSRTSAKRAWWKCRHGHSWSMKINERTILNKGCRICEQEYLSLFPALAVSYYSNKK
                     GLKAELGSDRLLGVPLETYIPSEKLAIESGSADENIEIMKAYMCKQRGIRMIKLPMKGT
                     ELDYANSLKKAFQSVHIFISSDTEEDVEIIKNTFERWRDSQ"
     misc_feature    5131..5142
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.05"
                     /tool="antismash"
     gene            complement(5169..6053)
                     /locus_tag="I2E58_RS10765"
     CDS             complement(5169..6053)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006428694.1"
                     /locus_tag="I2E58_RS10765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_195464942.1"
                     /transl_table=11
                     /translation="MLLNEIINEVEMTKRAVKYYEEKGLLSVDKDNNGYRNYTAQDVET
                     LKKISVYRKLGISIKDIQSLLETGDKSILLRIYQEKVQEKVLKDSELEALKQFIDDGDA
                     DKANEALDYQTVENAIESLLPGKEWGDYFKSHFKPFLNVRLKTLEQKQALQNILEYCDE
                     TTLKVPFIMGIGAKMIGGIAQETRTADEMIAYYRDMSESEYERLKEKVWKGAKMKNGIM
                     KYHPAFIAQRKMQKELQNKGYNDIFIPNLMVLSPTYAEYKKALDNVNDRMCRELGLYYD
                     SNYNLVIKKDNSK"
     cand_cluster    5865..31649
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    5865..31649
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[15864:22046](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(15865..22046)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
     gene            complement(6317..>6700)
                     /locus_tag="I2E58_RS10770"
                     /pseudo=""
     CDS             complement(6317..>6700)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015559615.1"
                     /locus_tag="I2E58_RS10770"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lysine--tRNA ligase"
                     /pseudo=""
                     /transl_table=11
                     /translation="EKIDFSKVKVEPLFEEMVDFDTFSKSDFRAVKVKECVAVPKSKKL
                     LQFTLDDGTGTDRTILSGIHAYYEPEELVGKTLIAITNLPPRAMMGIDSCGMLLSAIHE
                     EEGEEKLHLLMVDDHIPAGAKLY"
     gene            complement(6952..8190)
                     /locus_tag="I2E58_RS10775"
     CDS             complement(6952..8190)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006859226.1"
                     /locus_tag="I2E58_RS10775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /protein_id="WP_119245829.1"
                     /transl_table=11
                     /translation="MAKARKDNRGRALRKGESQRQSDLMYIYTYTDPFGKRKYTYSKDL
                     IKLREKEQKLLKDQLDGLDVYAAGNANLNFVFDRYISTKTELRRTTYTNYMYMYDHYVR
                     DSFGKKKIGEIKYSDVLYFYYHLINERKLQVNTLETIHTVLHPTFQLAVRDDIIRNNPS
                     HGVMSEIKKKPGRNHGVRHALTVEQQRAFMNYTSSSPVFNHWAPLFTVLLGTGCRIGEI
                     IGIRWEDIDLEKRLININHSVTYYPRRAETTKCEFAVSLPKTEAGIRTVPMMEPVYNAF
                     MEEYEYQKENGFSTVTLDGMEGFIFTNRFGNLHNPQAVNRTIKRIRENYNAEEILKAKK
                     EKREPIIIPHFSCHHLRHTFCTRFCENETNIKVIQAVMGHANIETTMDIYAEVTDMKKT
                     EAIEKLSHNLDIF"
     gene            complement(8227..8400)
                     /locus_tag="I2E58_RS10780"
     CDS             complement(8227..8400)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016292191.1"
                     /locus_tag="I2E58_RS10780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_226855577.1"
                     /transl_table=11
                     /translation="MAKMGRPKAESPKKKNVSFRLTEEEYQKLSEYAAKHELTTTQAIQ
                     KGIDLLYQMPEK"
     gene            complement(8500..8691)
                     /locus_tag="I2E58_RS10785"
     CDS             complement(8500..8691)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004070289.1"
                     /locus_tag="I2E58_RS10785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6462 family protein"
                     /protein_id="WP_015543500.1"
                     /transl_table=11
                     /translation="MQRHIINRKRFVRYKEGAEMYSMCQSKFEKMAKEANAVYKLDKLV
                     LVNCDIFEAYLETFRTGI"
     misc_feature    complement(8915..8928)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            complement(9079..9330)
                     /locus_tag="I2E58_RS10790"
     CDS             complement(9079..9330)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004613390.1"
                     /locus_tag="I2E58_RS10790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_015543499.1"
                     /transl_table=11
                     /translation="MKTEKKSVSNKKLIPLWVIERALEGDIQAINKILKHYEGYIAKLS
                     VRKMYDEYGCVHYCVDETLRRRLETKLIKTIIGFKIVR"
     gene            complement(9302..9754)
                     /locus_tag="I2E58_RS10795"
     CDS             complement(9302..9754)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004613389.1"
                     /locus_tag="I2E58_RS10795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma factor-like helix-turn-helix DNA-binding
                     protein"
                     /protein_id="WP_119245827.1"
                     /transl_table=11
                     /translation="MEQSSSYDEKTVRHQFDRKCKLALKGEVVDYERHLAYLRKHEVLF
                     SELSEREIENFSIINEYELEKSYFRAGGYDVVVKDALLAEALKALTERKRDVILLSYFM
                     EMNDADIARKLNLVRSTVHEHRTRSLEILKAMLEENVNENGKKKCK"
     misc_feature    9775..9789
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            complement(10001..10591)
                     /locus_tag="I2E58_RS10800"
     CDS             complement(10001..10591)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005421682.1"
                     /locus_tag="I2E58_RS10800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_119245826.1"
                     /sec_met_domain="AgrB (E-value: 4e-33, bitscore: 106.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLSEKITKYVIKTGAVSPELYVVYQYGFQIGLEMLCCFVTCFG
                     IAIYMHMIPEFVVFTGIFMLLRTYAGGVHLNSFGTCYVCSVAVQTLVMYFNNKYKFTVS
                     IAWILILMSAILILKAAPVESINRELDNTEKEHCQKVTMKILMGVIAFAICCTVGLIQD
                     MLSLISLTTFIILISQYVGILKYKIENSKNKRR"
     gene            complement(10593..10742)
                     /locus_tag="I2E58_RS10805"
     CDS             complement(10593..10742)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005337541.1"
                     /locus_tag="I2E58_RS10805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_015543498.1"
                     /sec_met_domain="TIGR04223 (E-value: 1.8e-16, bitscore:
                     52.2, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKDVKKQSAKMLASVSLKLGKMSADSACCYIYHQPKMPEKLKN
                     MKQS"
     gene            complement(10877..11278)
                     /locus_tag="I2E58_RS10810"
     CDS             complement(10877..11278)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS10810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_119245825.1"
                     /transl_table=11
                     /translation="MEKILLFSDDEKLFEITKQVTEGKQELIWGNYQCLETNGYPFADV
                     VIMHFDEEKIKKDIFQPIIKVKGRLGHSTPILAVIENGSMQDIFSVLKIGVYDYIETTD
                     NLEKYQKKIQDIILWEWYLKKYKGEVKKQ"
     gene            complement(11377..12684)
                     /locus_tag="I2E58_RS10815"
     CDS             complement(11377..12684)
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005337547.1"
                     /locus_tag="I2E58_RS10815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_015543496.1"
                     /transl_table=11
                     /translation="MWIDKALPYGADILLSAYAVYLFFYYFDIFFARKKSKKLWVAGLT
                     EFVLWQFGISTIISLPAYVNIAVTVIVTLFAVTITYEGMWWNKCVFVITFNAIWMLMET
                     LSNYVLMIYCEQYASIQPIGSFVSKSFFLAVIIALKKVFTDDEIKELSVRYSIMLVLIP
                     MGSIYIMNNVFMLGFTVNDNHTRINSAITVIILLVMNILIFYIYMKLADDLRLRRMASV
                     YEQQLELCERHQQEREISILQLRDAKHNMKNNLVSILAYAENRQHEKIIGFINEIMEES
                     GMAIAAISNSGNIVIDSLIGYWYVTAKKKEIDFKTDICIPMMLPFKGADICLILGNLLE
                     NAVEAAQKVDGKKYIEIKMKYDKNNILLSVTNSYSGKLLKTKDHRLKSTKTDTENHGVG
                     LASVYRAVAKYCGTVIIDDSVSGQFKIRVLLYGGQE"
     gene            complement(12671..13399)
                     /locus_tag="I2E58_RS10820"
     CDS             complement(12671..13399)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015543495.1"
                     /locus_tag="I2E58_RS10820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_195464946.1"
                     /transl_table=11
                     /translation="MLNIAICDDDIQTTGQIEMIIQKIAKRNFADVDIEVFWNGESLAD
                     SVVAGDGYDIIYLDIEMNNEDGISTAKRIRKYDKNVLIIYVTSHENYMKESFSVRPFQF
                     LVKPVSEKQMETCFMAAYEDINSGDFYFRYSYQRMNHKVLIRDILYFESSKRKVFIVTR
                     EETFEFYGKLNEIENSLKVCKISFLRVHQSFLVNYKHIKGQSYDFVVMDNGKKISISED
                     RRKLISEQYCSMEDTYYVDR"
     gene            complement(13405..13779)
                     /locus_tag="I2E58_RS10825"
     CDS             complement(13405..13779)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005337551.1"
                     /locus_tag="I2E58_RS10825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_195464948.1"
                     /transl_table=11
                     /translation="MESRIEQLREKRGLIQEILAAELGITQQMLSKYERDVTLIKVDIL
                     KKIATYFNVTTDYLLGVSDVKRDLQRQMKMNETLDEYYDLIEIYKDLDSYDKEMIWSIM
                     QTVKKVGEKRKKDNKLIEES"
     gene            14547..14786
                     /locus_tag="I2E58_RS10830"
     CDS             14547..14786
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS10830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_015543492.1"
                     /transl_table=11
                     /translation="MRSHTNEGVEGRIFTQFIALIIRNKIYTALQEKNEKLESKQNYMT
                     VPAVIKELEKIEMTRQTDNVYRLDHAVTAKQKKS"
     misc_feature    complement(14549..14560)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(15372..15758)
                     /locus_tag="I2E58_RS10835"
     CDS             complement(15372..15758)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005343038.1"
                     /locus_tag="I2E58_RS10835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_015543488.1"
                     /transl_table=11
                     /translation="MDKITHKVRCEQWTNIIKECLASGMPKMTWFREHGISDKSFFYWQ
                     RILREEAYLSTLENTLTPAVKENSVPTTTDFVEIKMTDHTSSSASPFKPDVVIRRGSVS
                     IEISNTATEELLNKVGGASTCCRI"
     gene            complement(15865..17187)
                     /locus_tag="I2E58_RS10840"
     CDS             complement(15865..17187)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="I2E58_RS10840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_015543487.1"
                     /sec_met_domain="LANC_like (E-value: 1.5e-66, bitscore:
                     216.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MECDILAMTKNIATNLSDYERMLKIMGRKENQRTWEGIEFEAFSP
                     LTLSHGLPGICLLYGKLMECCPKEDKWGRFAHNYLSLMVEELNKKGFQSLSMFSGAAGV
                     ALSVASVSNDFLNYNKLLNTLNDYILNRFEESYSNIVKEEGTHSLYYDVIEGLSGVLSY
                     LGIYRNQRKYYNVITRGLEILVNLTKDIEIQGQVVPGWYIPVQNQFSELEQDLYPKGNF
                     NTSLSHGIAGPLIILSDMMANGIIVDGQEEAIIKIIKFLFDFKLNDGERDFWKGQIDFD
                     EVVNKKLTDENIIRRDAWCYGNPGICYAIVSAGNALDNQRLIDYGIENLRLTMNNIKGI
                     FSPTFCHGYAGLYQVLNSVEMLLQKEFFSLEKELLKNKIIDFYNPDYIYGFKNMELDNK
                     MEKIKPYDVCGLLEGTTGVCLSLLEGEKKSDNLWKKAFLLA"
     gene            complement(17192..18994)
                     /locus_tag="I2E58_RS10845"
     CDS             complement(17192..18994)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="I2E58_RS10845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015543486.1"
                     /transl_table=11
                     /translation="MNNKKVGFKEVWRALKQIPKTITIIRKVDKKGFTLIVMLSMIAGA
                     FPVITLVLSQELINSIVKKSSPLRYTIILFTIYIIVSFLGSILGEAKDYIESKFQYVLQ
                     YKLNYLIMDKCTKLTLKDFETPAMYDKIEKITGEVAYKPYQIMIAIIGIITSVVTMLSS
                     AFLLFAWNPYISMLLLVVPIISMLYYLKIGQQEFEIMWNRAKDERKTWYLTYLLTHDFS
                     FKEISLLDLKDYFLKKYWSISALFIRQNTSILKRKTLFNILYELSIQIVSAIIIGVAIM
                     SAYVGEILVGNVMSYIRSVGLVQTNSQAIMSNIYTVYSSTLYMDMLFQFLNYCVKEDSS
                     EKIVMKEPINKIDIKELSFSYNGKTKVLDKINLTLVQGEKVALVGPNGSGKSTFLKILA
                     GLYNIEEGEILINGRSLKDLDIRSYRSKMSVLFQDFVKYELSLRENIGFGDIQNLNNDE
                     KMVQMLHKLQTKFLQTDNGSYNLDLQLGNWFEDGCQLSQGQWQKIALGRVYFRDASFYI
                     LDEPNAALDTVSEREVFEKFFELSKDKIGVFISHRLNAAKMADKIIVMDKGKIVGIGKH
                     DELLRNCMTYQKLYKAESYEREDM"
     gene            complement(18987..22046)
                     /locus_tag="I2E58_RS10850"
     CDS             complement(18987..22046)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="I2E58_RS10850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_119245822.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-127, bitscore:
                     419.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.9e-14,
                     bitscore: 44.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-31, bitscore:
                     101.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYYNTQKFMFRIPTDVERKLDFTEDEIKNACLDAKFREKVSI
                     ASPALVDMMDLYIKNPEKLSEKKLVNFQNSIMKYLIRSKNRTTPFGLFSGVGLGKFGDS
                     DTFDVSGAKYQKKVNIDSEWLFGFISQLEKIKSQRLRFKINDACYIKGNRAILLYSTEK
                     EIEEISVRATRVFEIIYESCQEFKEYNQIAGIIEEEYPNVPNEKVTFYLNELISKEILI
                     SDLRPSLNSRDQIAYVIERLRESALFEEAGNIIEIRKMCTSYMNLPVGEGITLYDKIVS
                     KMKLLYSCSSYLQVDTVIENAEFEIKSTVANKINRLASFFVYISNDKNESHTYLDEYRN
                     KFIEKYGVDREVPLLEMLDSNIGIGAPTSYLNPQNDFFEEDSTKPNYNLRLKNYLLNKY
                     ESAITNKTSITLEQDEIEGILKREIKTDEVPISLELYFQLKKKNDELNLCLGPNCGSLV
                     AGKTFGRFSTISDEFADMLEDINKEERRLRDDNIEMCEIGFLPAPARNGNIVRTRTFRE
                     KKTVIFTAADKGTTDVINIKDISIGVFNELFYARDYKTKKLVVFESNNMYNPMLNPNIL
                     RFLQDISHEGKRSWSEFPWTYIFSEFRHVPAIKFEDIVIENEKWKLNLSEMRLEKKNFE
                     EFKCKFLQLIKDKNIPDDIYLTEADNRIKLDLKKELSIRIIFDEFKKHGSRDLILERAE
                     TGENITYSGEGGHTTEIVVPLFRKEKELQNIYPAEKVIIERKKHLELPFENWLYFNLYC
                     NSNREDELIAFDIMDFCEELKKKYDVDYFFMRYVDPKPHVRLRIKGTQEVLLQIYPLII
                     KWQHQLLDDGIIGDLKISIYDREIERYGGLHLMDIAEQVFFIDSFIVESILRMKRLGVL
                     AIDQEDIAIISIIMYTQGFYETFEEQMNFLAINYHTSDFMSEFKKKKQRLVSLCGCEND
                     WKELLSNEEGTSLYNLLNMRTVVLNKYRDEINNINQDPLFKNSIVASVIHLHCNRIIGT
                     DRELERKLMAFSESIMYAKRYIMKRNEDHE"
     aSDomain        complement(21363..21620)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I2E58_RS10850_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.50E-14"
                     /identifier="RREFam001.1"
                     /label="I2E58_RS10850"
                     /locus_tag="I2E58_RS10850"
                     /protein_end="228"
                     /protein_start="142"
                     /score="44.3"
                     /tool="antismash"
                     /translation="KINDACYIKGNRAILLYSTEKEIEEISVRATRVFEIIYESCQEFK
                     EYNQIAGIIEEEYPNVPNEKVTFYLNELISKEILISDLRPS"
     misc_feature    complement(22086..22100)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.15"
                     /tool="antismash"
     gene            22168..22371
                     /locus_tag="I2E58_RS10855"
     CDS             22168..22371
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS10855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_015543484.1"
                     /transl_table=11
                     /translation="MKTKEELLLSVKEDIEAFGKDKLVYTHMSLQNEGTILYGYSYTPE
                     GKFIDEASLEELLIILESDTDM"
     gene            complement(22418..23776)
                     /locus_tag="I2E58_RS10860"
     CDS             complement(22418..23776)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="I2E58_RS10860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_015543483.1"
                     /transl_table=11
                     /translation="MGYKIITMKRQLLLYLIKLFMGIVIIIICWLALTNIFVECGVIIP
                     ANYSETILEENRKRLDDIQQITDNDLPYGSKYSIFDLDYNYERGTMNKSDIEVTKKILL
                     GKESNLQGNYVYSVIARTEEYCVIKYNIKARFNSDNKIFNYIDYDNLSYITMVLVFLLY
                     VYIMTLHLVGIWKNNFEKIEKITLEIEKQNLDFTYEESKIKEFSNIITALIKMRDALKE
                     SLYQTWKIENEKNEEIAALAHDIKIPLTIISGNTELLKCYSSDEYSLSHLQSIWGAVGK
                     MEEYINLLIKYVKADRIDFHEKESMPCNSFSHKIVSEIKEYISGSEEIIKFNVEKVRGT
                     IKIDYISLERAIFNIIDNAIEYKVYGDKIMCFIGKKDDSYIFTICNEKGEFSSQVLENG
                     TKLFFTSNNNRNSIHYGIGLAYANKVIQSCEGELELYNSKEHGAVVSIKLPIT"
     gene            complement(23761..24426)
                     /locus_tag="I2E58_RS10865"
     CDS             complement(23761..24426)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="I2E58_RS10865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_015543482.1"
                     /transl_table=11
                     /translation="MENILVIDDDEKILELVQEVLKNEHYIVETRSYVDNTNIGEFEGF
                     DLILLDIMLPFLDGYEILERIKNIITCPVIFLSAKSSEGAKVKGLMSGADDYITKPFSI
                     RELVARVKVALRRNLKNGSNGILINGLVFNQDSNSIKLDNGEILLTKNEFRICKILVQN
                     SGKIFSKDELYEYLYDLDANAQLRTITEFIYSIRKKFKTLGLDPIKTIWGIGYKWDIK"
     gene            complement(24759..24929)
                     /locus_tag="I2E58_RS10875"
     CDS             complement(24759..24929)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="I2E58_RS10875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_117640235.1"
                     /sec_met_domain="TIGR03731 (E-value: 4.8e-18, bitscore:
                     57.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKFDDFDLDVTKTAAQGGIEPKYKSKSACTPGCPTGILMTCPLK
                     TATCGCHITGK"
     CDS_motif       complement(24861..24929)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAKFDDFDLDVTKTAAQGGIEPK"
                     /locus_tag="I2E58_RS10875_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(24759..24860)
                     /prepeptide="core"
                     /locus_tag="I2E58_RS10875_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="12.50"
                     /molecular_weight="3228.9"
                     /monoisotopic_mass="3226.6"
                     /core_sequence="YKSKSACTPGCPTGILMTCPLKTATCGCHITGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKFDDFDLDVTKTAAQGGIEPK"
                     /leader_location="[24860:24929](-)"
                     /alternative_weights="3246.9"
                     /alternative_weights="3264.9"
                     /alternative_weights="3282.9"
     gene            complement(24953..25123)
                     /locus_tag="I2E58_RS10880"
     CDS             complement(24953..25123)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="I2E58_RS10880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_151190481.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.5e-18, bitscore:
                     57.8, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKFDDFDLDVTKTAAQGGIEPKYKSKSACTPGCPTGILMTCPLK
                     TATCGCHITGK"
     CDS_motif       complement(25055..25123)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGKFDDFDLDVTKTAAQGGIEPK"
                     /locus_tag="I2E58_RS10880_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(24953..25054)
                     /prepeptide="core"
                     /locus_tag="I2E58_RS10880_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="12.50"
                     /molecular_weight="3228.9"
                     /monoisotopic_mass="3226.6"
                     /core_sequence="YKSKSACTPGCPTGILMTCPLKTATCGCHITGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGKFDDFDLDVTKTAAQGGIEPK"
                     /leader_location="[25054:25123](-)"
                     /alternative_weights="3246.9"
                     /alternative_weights="3264.9"
                     /alternative_weights="3282.9"
     misc_feature    complement(25324..25337)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.81"
                     /tool="antismash"
     gene            complement(25630..26988)
                     /locus_tag="I2E58_RS10885"
     CDS             complement(25630..26988)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="I2E58_RS10885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_119245819.1"
                     /transl_table=11
                     /translation="MGVKIKKRQYSLKFFFIKFILSLIIGAGVSIALPLVLATLASNMG
                     YITVANYNEIQAEKTAKILETEKNPDYKNIPAGIKYLIISKEFDILNTNMSNGEQKDAL
                     RYANGKFEKTASGKQFILVTRDKEFCILQYYIGSHFTNIWLDIHMPSPDILINAGMILN
                     CLFVFSIMVFLFAKELRKELKPVMDATTKIEEQELEFNISSSRIIEFNDILKSIYNMKN
                     SLKKSLKTQWNIECQQKEQISALAHDLKTPLTIIGGNADLLSETNINQEQEEYINHILE
                     SSKRMENYIAILIDLSKNTGEIPINRESISIGKFIDSIKGQMQSVVAMKKMNLIIAIMD
                     ESFRIEIDTVLMERAIINVLSNAVDHSPTHGEIIFNVTKDKGKCKISIIDSGPGFTPAA
                     LKYGLERFFMDDKSRNYQHHYGMGLYITNSIVTQHGGKVELKNKRGAEVDIII"
     gene            complement(26979..27644)
                     /locus_tag="I2E58_RS10890"
     CDS             complement(26979..27644)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018597936.1"
                     /locus_tag="I2E58_RS10890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_119245818.1"
                     /transl_table=11
                     /translation="MIKILVIDDEEAILELVKRGLEKDGFAVDTLTSAKKVDVSKLRQY
                     NLLILDVMMPDIDGFTFCKKIRDIFNAPILFLTAKTLEDEVLYGLGIGGDDYITKPFRI
                     KELRARVKAHLRRESRENHDYLFSEDGNIKFDLSAKKLLVCEKEIPLTHSEYKICELLI
                     QNRGHVFSREKIYERVFGFYGESADNTIVVHVKNIRVKLSEAGVNPIQTVWGIGYKWE"
     gene            complement(27706..28542)
                     /locus_tag="I2E58_RS10895"
     CDS             complement(27706..28542)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033433.1"
                     /locus_tag="I2E58_RS10895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_015543481.1"
                     /transl_table=11
                     /translation="MKNSILIKRVILVFCMISIMIIGSGCAAKKTVLENQGKTECYLDE
                     KDATKFIYNGQQYTILNNTVDKNSLGDWIGFIQKYVALDENYNILKKCDMGVNVVGDLS
                     DLIDHTDGTAYYVPYLNVYKTENEGDMNNLVVDVDNDFHKAIPSENAKDGDLKIIFKNQ
                     NDTKDIENDLPQIDKEDVRNLTWEGKTYQITDQVVPNEKIGDYLCTLSGNITFDAETGR
                     ELTHDELNAIDIIPGELSNQKRETWIYDSVYTVIGKDKDSLAVEINYKCVYAILKD"
     gene            complement(28532..29293)
                     /locus_tag="I2E58_RS10900"
     CDS             complement(28532..29293)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03733.1"
                     /locus_tag="I2E58_RS10900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_015543480.1"
                     /transl_table=11
                     /translation="MKSLWYAIKSEVVKLRHTPIFLLHIIVPLLGGLLFAMYFHLYSGQ
                     QSITQRLNLILQATSAFFPLAISIAVSLGINLEEEGHFQALFVGMESKSKLIIAKLILF
                     LGIGAVAIVILFLPILFSVAVMDQELSISVLNTVLYSYVYLVLGNIVTYIIHFWLSLKS
                     GLGASVITGVLESLIVILFSNLPLKLVISWEYIPWAWAVNMCRQEILQFNTQLSTLQPN
                     IIFKVIIITFVLLLVFCIWFEKWEGRKNYEE"
     gene            complement(29290..30009)
                     /locus_tag="I2E58_RS10905"
     CDS             complement(29290..30009)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03732.1"
                     /locus_tag="I2E58_RS10905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_015543479.1"
                     /transl_table=11
                     /translation="MRYIRSENLKYKRSFSRKLIFVVPIITAFVAVIFGGIRNFQAQTI
                     YWWYTFLLPGTVAIYCSLSEKKEKSVRYHTFYTLSIDLENAWYARVLVIAWYMLLTGII
                     LVLPAVSMKIWAPAICQISNGKLLLGSICIVVMSLWQIPILLFFNKRIGILLPLIINCM
                     LPLAISPLSNTDLWFLIPYSWVSKSMKSIIGLDVNGTMTTVSSKDSLDFTIGLLLSVLL
                     FIITVIITAKKFREVEG"
     gene            complement(30009..30713)
                     /locus_tag="I2E58_RS10910"
     CDS             complement(30009..30713)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009296714.1"
                     /locus_tag="I2E58_RS10910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_015543478.1"
                     /transl_table=11
                     /translation="METLLRTENLTKKFKNQVAIQNISMNVPENSVYGLLGPNGAGKST
                     TLKMIAGILKPTRGSIIFNKHPWKRSDLSNIGALIETPPLYGNLTARENLKVRTELLNI
                     SDGRIDEVLEISGLTGTGKKRAGQFSMGMKQRLGIAIALLNNPKLLILDEPTNGLDPVG
                     IEELRNLIRQFPKQGMTVILSSHILSEVEQIADYIGIICNGKLEYEAPENKEDNLEALF
                     MDIVKRNRREII"
     misc_feature    complement(30798..30810)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    30905..30920
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.64"
                     /tool="antismash"
     gene            complement(31182..31565)
                     /locus_tag="I2E58_RS10915"
     CDS             complement(31182..31565)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2E58_RS10915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_015543477.1"
                     /transl_table=11
                     /translation="MKKMISILTVLVLSIVTMLPVKVMAAEYPHKNSEVKHVNLLSDKT
                     EYGIQPQTDGYYYWKVDSKTNQGTTYGSWRLGPQGAGPGTVSVNKTDTVTNTISGSYTS
                     VGDISASLGATIGKSQSYSVQYP"
ORIGIN
        1 tgttttccac tgcttttcta aagattctcg caatgcatct cgcatatcat cgattgccga
       61 taaacagtca tcaaactctt tgataccgga acaggatgtc tcatattcca gattttgatc
      121 ctttatttgt ccgattgcgt ctaatacagg ctgcatctgc tttttgattc tttttccaaa
      181 acgtatggac ggaatgatga taatcgctac cgctccaatc acagacataa taatcatcac
      241 attctgtggt tctataaaat gctccctcaa aaaagctgaa tgatattgag gtgtcaggcg
      301 atattgcaat acaacatatt cattttccct tacaattact ttataaaaat atttcccgga
      361 tgcgtttccg tactttgcaa cattccatgc tatctgttcg tattgttctg acagatctcc
      421 acctattttc tctccattct ctgaaaagat tacataatca caaagtgcgg gaatcatctc
      481 agcagtcact ttatctgcac gtagaatcgt atcatatgct tcattaatct tttgctctgc
      541 ataatttgcc ggataaatac agcccacact aatcaaaagg tacagcagca gataagcaac
      601 aatcaccaaa ccaactaatg atccaagcat gaccagtaca tatctcataa aaatcctgct
      661 gagtgcattg cttctcttta ctcttcccat ttatatccaa tcccccagac tgtttttatc
      721 ggtgtataat cataatccgc aaattttgct cttatatttt tgatatgcgt gattatagta
      781 ctgtcattac tctcattgtc aaagccaaag accgcttcca atatctgttc cttcgagaaa
      841 acctgtcctc tgtttttagc cagaaattca cagatttcgt actccgcttt cgtaagagga
      901 agttccttat catcaaccaa tagtttcttt tgagatattt gaatacagac cctccccaaa
      961 accatccgga cagaatgttc cctgtgctct cttctaagat gtgcattgat ccttgcccga
     1021 agttccatca ctccaaatgg ctttgaaata taatcatctg ctcctaaaga aagtccgttt
     1081 accagactgt tttcctccgt ttttgccgta agaaacaaaa tcggacaatc cacaagtatc
     1141 ctaattcttt tgcataattc gaagccatca attccaggca tcataatgtc cagtaaaatc
     1201 aggtcataac gatgtaattc ttccatatta atttttagtg gattacttac tttggtaacc
     1261 agatgtccat ccttattcaa aatgctttct atcatttcca aaattgccgg ttcatcatca
     1321 actgccagta tttttgccat agtttccctc gattctattc cgatattctg tttccttccc
     1381 agtggtttac ccaccaaaaa tagtatacca tactaatccc tgtaaatatt aagcaacctg
     1441 gtatgaatga caaccattca cctacactag tttctcccaa tacagattgc agataagtat
     1501 atggtactct acccgtccag cagacaaata catatttcca cacataatct ccaagtccgg
     1561 taagcatcaa tgcactaatt agtcctgata taatccctgc tccaatggat accccttttc
     1621 caaactgaaa agccagaatc agctgccaca gataaagtgg aacactgctt ccccacagca
     1681 gcaatgctgc aaatatacat cctttcatga tttcgatatc gcttgatgcg attcttccaa
     1741 atccaattcc gaatatgatt gctgtcaata ggatagagca cagacacaaa accagtagca
     1801 tcaacagttt cgataaaaat gctgcaggtt tatccggtaa agacaacaga ttttgaaaat
     1861 cacctgcatt ttgttcttgt tccatcacac ttgctgtaaa aattccaata agtaccggaa
     1921 gtcctgctcc tattgcctga taaaatgcaa tcactttcat attttcattc catggtgaaa
     1981 aaaagtaata tattaaaaat ataacgctgg ttataatcgg aatcaataag tgtgccagaa
     2041 tcacagatgt tcctttcatc tttcgcaagt ctgcattaag agatcttcca atcatcttat
     2101 ttcacctctc ttctctcaaa ccatttcaaa aacagaaccg ttacaaaaac aaaccagatg
     2161 attgagagac acattcccgg aacaatgact cccgtatcca aaagaggatt ccctgcttct
     2221 gcggcaagtc catttggtaa aacatgaagc aacgggcaca tcattcgcat agggattgca
     2281 gaaacaagta cataccagat tctggtttgt gatattacca caccgctgac ggtaataaat
     2341 aggcagacga acaggtttac aatcattcca aatcgttcac ttaaaaataa agctaccgga
     2401 atctcccata actcagaaac cgtcagaaac aatactgcaa tcaacgctcc tccaactgga
     2461 acatgtgtcg ttagaagaaa gcctccaagc gttgctcctg caaacacaat cacattagaa
     2521 aacaaaatca tgtacccaat ataaataatt ttccccagca acaattttct tctgtctgtg
     2581 ggaatagtca ttaaatgata gtattttatc tttttctcct gcgccacaga aagataacaa
     2641 aatagagcaa tcatccccgg cagcaaaagt gtataccacc agttccaaac actttctgca
     2701 taagcatttg tcatcccaag agtaaatata aatgccatga caaatgtaag aagaggaaat
     2761 ccccagataa acttttttcg catggttctt ttggcttttt gatgttctgc ttttataata
     2821 ttaaccatgg atttcacctg ctttctggtt ttttcttacc acattcataa acaaatcttc
     2881 aagattatct ccctgcttta atgctccttc gtatcctaag attccacctg aaataatccc
     2941 gactttatct gcaagtaact gtacctctga gagaatatga ctggagagaa ttacagtgat
     3001 tccctgttcc ggaaaagacc ggatcagctc tcgtaattcc tcgatgccta ttggatctaa
     3061 tccattcgta ggttcatcca atatcaaaag ttccggttct ccaagcaatg ccattgcaat
     3121 gcctagtctt tgcttcatcc ccaaagaaaa ctgtcctgct ttcttctttc cggtgtttgt
     3181 aagtgataca atctgcaaga cctcatcaat tctgttttca tctgtaccaa gcaataattg
     3241 tcttaccttc aaattctctc tggcggaaag attttcataa ataggcggat tttcaattaa
     3301 cgctcctatt tttgataaat ctttcctatc caaaagtttt ccatcaaagt aaatctttcc
     3361 tgcagttggt ttcatcatac cggtcagcat tttcaatgtg gtagatttac cagcgccatt
     3421 cggtccaagc agtccataaa tctgtccctt ttcgatatta agtgaaacat tatttaccgc
     3481 tttctgtttt ctaaaatatt tacatagatt ttgtgtctgt aacatcattt ccatctttac
     3541 tatccttcct tctatatttc atttcttact gaaatataac ctaacagaaa aaaataaaga
     3601 tttgatgaag atttattccc gtatggaata aaccatcaat tgaatatcat tatcagaact
     3661 cggctttcca ctgaaatcag caaagctgtt acaaatacga agtcctaatt tacagaatat
     3721 ctccgtgatt tcatccaaac tatataacct tataggattt cactcatttg gacaaagggg
     3781 tatgaaatgc acacccaaaa tcgccgcttt tccgaaaatt tttttgaaaa attttttgaa
     3841 ataaaaaaag ccgcctgctc cggttaggaa acagacggca aatcaacttt ctaaatgtat
     3901 tcaattttca atttcttttt ctttgcttca agcactttac atagaacatc atctactgcg
     3961 tcggtgtatc gtccctgagc tgctaaattg ttcttcaatt caatgagcga ttgtatcact
     4021 cggcttcgtt cttcttcatt taagtataga tgataggctt tctctctcat tggctatccc
     4081 tccatctttc aaatgtattt ttgattatct ccacatcttc ctctgtatca gaagaaataa
     4141 atatatgtac gctctgaaaa gctttcttta agctattggc ataatccagt tctgtgcctt
     4201 tcatcggcag cttaatcatc cttattcctc tttgcttgca catatatgct ttcattattt
     4261 ctatattctc atcggcactt cctgactcaa tagccaactt ttctgaaggt atgtatgttt
     4321 caagcggaac tccaagcaat cggtcagaac caagttctgc tttcaagcct ttcttattag
     4381 aataatagct gacagccaaa gcaggaaaca atgacaaata ttcttgctca caaattcggc
     4441 agcctttatt caatatcgtt ctttcattta tcttcatact ccacgaatga ccgtgcctgc
     4501 atttccacca cgctctcttt gctgaagttc gtgatacttc tgtcggcttc aatttattct
     4561 gttcataatc ccattcactg agaagctgat tatctgtcgt cgccaaatca ttatatccgg
     4621 caagaacttc tctctccgca caaacggggc ataccgtacc tttcacacga gcattgataa
     4681 ctgatttcca ctcgttaccg catttaccgc atctccacca gacatttttc ctcgactttg
     4741 catttacctc atcaggtttc aacggcaagt tcttttctga ccactccgaa gcaatttcag
     4801 ggtgtgttgt ctgcaaatcg ttaatacctg caatcactct cgcaccagaa catatcgggc
     4861 atttttctcc attagaacga gccttaatgc ttgtctgcca ttcgtgaccg caagcacctt
     4921 tccaccatac ttttttattt gagccgaagg taatatcatc aggtgtaagc ggtaaattct
     4981 tctccgacca ctccgtaata agctctgggt gtacttctgc taaactgttg ttcatagcca
     5041 aacctcaacc tccttgtatt tagagtatat gaagttttgg ctttatcttg tagtttgcga
     5101 atatccgtat aaatagaaaa agccctttga gaaaaggatt tctcctctct caaagggtag
     5161 tttaactttt acttagaatt atctttttta ataactaagt tataattgct atcataatac
     5221 agtccaagtt ctctacacat tctatcgttc acattatcta acgctttctt atattctgca
     5281 tacgttggag acagaaccat taaattagga atgaatatat cgttatatcc tttattttgt
     5341 aactctttct gcatttttct ctgtgcaata aatgctggat ggtatttcat tataccgttt
     5401 ttcattttag cacctttcca tactttttct tttagtcttt catattcact ttcactcata
     5461 tcacgataat aggctatcat ctcatctgcg gttctggttt cttgtgcaat tccacctatc
     5521 atcttcgcac ctattcccat aataaaagga actttcaatg tcgtttcatc gcaatattct
     5581 aatatattct gtagtgcctg cttctgttcc agagtcttca accttacatt aagaaatggt
     5641 ttgaaatgac ttttaaaata atctccccat tcttttcccg gtagcaaaga ctcaattgca
     5701 ttttcaacgg tttgataatc aagtgcctca tttgctttgt ctgcgtcacc atcatctata
     5761 aattgcttca aagcttcaag ttctgagtct tttaaaactt tttcctgcac tttttcttga
     5821 taaatacgaa gaagaatact tttgtcgcca gtttccaaaa ggctctgtat gtctttaata
     5881 ctaataccga gttttctata tactgaaatc ttttttaaag tttcaacatc ttgtgcagta
     5941 tagttacgat aaccattgtt atctttatcc actgacagca atcctttttc ttcataatac
     6001 ttaactgcac gctttgtcat ttcaacctca tttataattt catttaataa catcagatgc
     6061 acctccttat gatttatgtt gatagtataa gcgtatacgc tgcgtgcagg tcaagagttt
     6121 ttcgtctttc ttctaaaaat gggcaatccc gatttcagga ctgcccattc attctgctaa
     6181 ttatgcgatt ttttcttgct tgcaccgatt tctgcatcaa ttgatgtaag tttgatgtaa
     6241 atcgctgttt ttttagtttt ttatcaaatg aagtacgtcc cgtctatttt gtaaaacggt
     6301 acatctttac atcatcttaa tagagctttg cacctgctgg aatgtggtca tcaaccatca
     6361 gaagatgaag cttttcttcg ccttcttctt cgtggatagc actgagaagc ataccacaag
     6421 agtcaatgcc catcatagct ctcggtggaa gatttgtgat agcgataaga gtctttccaa
     6481 ccagttcttc cggctcataa taagcgtgaa taccgcttaa aatggttctg tctgtgcctg
     6541 ttccgtcatc aagagtaaac tgtaacagct tctttgactt cggtactgca acgcactctt
     6601 taacctttac tgcacggaaa tctgacttgc tgaatgtatc aaaatcaacc atttcttcaa
     6661 acaatggctc gacttttacc ttagaaaaat caatcttttc aaccggtttt tcagcctctg
     6721 caggagctgc ttcggaagtc ttatttgcct tcttatcagc atccagtgac ttcattgtcg
     6781 ggaaaactga ttcgcttacc atactatccc gtactgtcgg gtattataca ttattttcca
     6841 aaagacttca acctattata aagtattatt cagtatgtat ttgttgtact tctgttgcac
     6901 accacataat tctgttgcac ctcatagaat caagcccaca aggactcttt cctagaatat
     6961 gtctaaatta tgtgataatt tttctattgc ttctgttttt ttcatatcgg tgacttcggc
     7021 atatatatcc atcgttgtct caatatttgc atgtcccata actgcctgta tcaccttaat
     7081 attcgtttca ttttcgcaga atctcgtaca aaaagtatgt ctcaaatgat ggcaggaaaa
     7141 atgtggaata atgatcggct ctcttttctc cttttttgct ttcaaaattt cttctgcatt
     7201 atagttttcc cggatacgtt tgatcgtccg gttaactgcc tgcggattat gaagattgcc
     7261 aaaccgattt gtaaagataa atccctccat accgtccagt gtgacggtac tgaatccatt
     7321 ttctttctga tattcatact cttccataaa agcattatat actggctcca tcatcggaac
     7381 tgtacgaata cctgcctctg ttttaggtaa tgaaacagca aattcgcatt tggttgtttc
     7441 tgctctgcgt ggataatatg taacactatg attgatattg atcagtcgtt tctctaaatc
     7501 aatatcttcc catcgaatcc caataatttc acctatacgg catcctgtac ctaaaagaac
     7561 ggtaaacaat ggtgcccaat gattaaatac cggactgctc gatgtataat tcataaatgc
     7621 tctctgctgt tctactgtca acgcatgtct cactccatga ttcctccctg gtttcttttt
     7681 tatttctgac attacaccat gagatggatt gtttcggata atatcatctc tcactgctaa
     7741 ctgaaatgtt ggatgaagca ccgtatgaat cgtttctaat gtattaactt gtaattttct
     7801 ttcatttatc aaatgataat aaaagtacaa tacatctgaa tatttgattt caccgatttt
     7861 cttctttcca aaactgtctc tgacgtaatg atcatacatg tacatataat tggtataagt
     7921 tgttcgcctc aactctgttt tcgtagaaat atatctatca aatacaaaat taagattggc
     7981 atttcccgca gcatacacat caagaccatc taattggtct tttaacaatt tctgctcttt
     8041 ttcccttaac ttaattaaat ccttggaata tgtatatttt ctttttccaa atggatctgt
     8101 ataagtgtat atgtacatca ggtcggactg gcgttggctc tcacctttgc gtaaggctct
     8161 gcctctgtta tcttttcttg cttttgccac tgtaactcct tcctaatgta gcaaggagtc
     8221 cttgtgttac ttttctggca tttgatataa aagatcaata cctttttgta tcgcttgtgt
     8281 tgtagtcagc tcatgcttcg ctgcatactc tgacaatttc tgatattctt cttctgtcaa
     8341 tcggaaactt acatttttct tcttagggga ttctgctttc ggtctcccca ttttagccac
     8401 cgtatgcacc tccttcatag cttgattaca ttatactttt tgtcatgcaa aaagtcaata
     8461 cttttcgtag cacaaaaact cttgcaatac tattcatcac taaataccag ttcggaatgt
     8521 ttccagatat gcctcgaaaa tatcacaatt caccagtacc aatttatcca gcttatagac
     8581 agcatttgct tcctttgcca ttttttcaaa cttgctttga cacatgctgt acatttctgc
     8641 accttcctta taacgaacaa atcttttcct atttataata tgtctttgca ttctttcgct
     8701 cctttcccaa tttataacaa tcccacaggc agctatcggg taacagcttc attggtattt
     8761 caccatcttt ccagaccggg cagctttccc ggaagtatca ttatcagaaa cagtatcttc
     8821 gccacaaaag tcccacttcc tgattacagt caaatattta tcgctcgtgc ctttacttca
     8881 atattatttt gatatttctt cgtttacaac attttcactt tgcgtcacaa tgtcgcaaag
     8941 ttataatgca gacagtcttg gcgtatttgc tatacagctc ctctgtttca tatgtcctgc
     9001 aggataaata ttaaattttc aaggtgcaaa caacgctaaa tagattttcc tgcagaaagg
     9061 gatgctctca aatgtttttt agcgaactat tttaaatcca ataattgttt ttatcaattt
     9121 tgtttccaga cgtctgcgaa gtgtttcatc tacacaataa tgaacacagc catactcatc
     9181 atacattttt ctgaccgata attttgcaat atatccctca taatgcttca gaattttatt
     9241 tatcgcctga atgtcaccct ccaatgctct ttcgattacc caaagcggta tcaatttttt
     9301 attacttaca cttttttttt ccgttttcat ttacattctc ctctagcata gcctttagta
     9361 tttcaagtga tcgtgtccga tgctcatgta ctgtacttct gacaagattc aattttcttg
     9421 ctatatcagc atcattcatt tccataaaat acgataaaag aataacatcc cgttttcttt
     9481 ccgtcagtgc tttcaatgct tctgccaaaa gagcatcttt taccaccaca tcataaccac
     9541 ctgcacgaaa atagcttttt tccaattcat actcattgat tatagaaaaa ttctctattt
     9601 cccgttccga taattctgaa aacagaactt catgttttct aagatatgcc aaatgtcttt
     9661 cataatccac cacttcgcct ttcaatgcta atttacattt tcgatcaaat tgatgcctga
     9721 ctgttttctc atcataggaa gaagattgct ccatagagtt cacctccttc ccgaccacaa
     9781 gatatgagca aaggtctttt tccctttcac ccttatcccg attgagaact tcccattgtt
     9841 cgggtttaaa agaaaaactc tataaaaagt tttcgtaata tataaaaaac gtccttacgg
     9901 attgaaatcc attggacgtt tttatataaa taatctaata ttcaaaaagt aatcttctcc
     9961 attctttcta tgtaataaaa aagcggaaat aataatttta tcatctccgc ttattcttac
    10021 tattttcaat tttatatttc aaaataccaa catactgaga aattaaaatt ataaaggtag
    10081 tcaatgaaat caaagaaagc atatcctgta ttaaaccaac tgtacaacaa attgcaaatg
    10141 caataacacc cattaaaatt ttcatagtta ccttttgaca atgttctttt tcagtattgt
    10201 caagttctcg attaatactc tctactggtg cagctttcaa tataagtatt gcactcatta
    10261 gtataagaat ccacgctata cttactgtaa atttgtattt gttgttaaaa tacattacta
    10321 gtgtctgtac agcaactgaa catacatagc atgtgccaaa gctgttaagg tgtacacctc
    10381 ctgcatatgt cctcaataac ataaaaatcc cagtaaatac tacaaattcc ggaatcatat
    10441 gcatgtatat tgctatgcca aaacaagtta caaaacagca tagcatctca agtccaatct
    10501 gaaagccata ttgatatact acatataatt ccggagaaac agcaccagtt tttataacat
    10561 attttgttat cttttccgaa agttgtttca tattaagact gtttcatatt tttcagcttc
    10621 tccggcattt tcggctgatg ataaatataa cagcacgcac tgtcggctga cattttgcca
    10681 agttttaatg acacacttgc cagcattttt gccgactgtt tttttacatc tttaagcttc
    10741 ataatagaag tcctccttca tttgttttct tacatcctac tataaaaaac ttatcctttt
    10801 tctttcttgt aaaaaaaacg agtattcatg taatttttcc atacaatatt gttcaaaaaa
    10861 acaatgacca cactgatcat tgctttttta cttcaccttt atattttttc aaataccact
    10921 cccataaaat aatatcttgt attttcttct gatatttttc taagttatct gttgtttcta
    10981 tgtaatcata cacacctatt ttaagaactg aaaaaatatc ctgcatactt ccattttcta
    11041 taacagcaag gattggcgtc gaatgtccta atctaccttt tacctttatt attggctgaa
    11101 atatatcttt tttgattttc tcctcatcaa aatgcattat aacaacatca gcgaatggat
    11161 atccatttgt ttccaaacac tgataattgc cccatattaa ttcctgtttt ccttctgtta
    11221 cttgtttagt aatctcaaac aatttttcat catcgctaaa taataatatc ttctccacgt
    11281 taagacctca tagcagcata attaatttat cgttttattt taccaccatt tttatagact
    11341 atatttttgt tgtaataatt tcgagagttt atgtaactat tcctgccctc cgtataacaa
    11401 tacccgaatc ttaaattgtc ccgatacaga gtcatcaatt ataacggtcc cacaatattt
    11461 tgcgactgcc cggtaaacag atgccagtcc aacaccatga ttttcagtat cagtttttgt
    11521 tgattttaat cggtgatctt ttgttttcag caattttcca ctataactat ttgttactga
    11581 aagtaaaata ttattcttat catatttcat tttgatttct atatatttct ttccatccac
    11641 tttttgtgct gcttctactg cattttccaa taagtttcca agtatcaaac atatatctgc
    11701 gcctttaaac ggtagcatca taggaatgca aatatccgtt ttaaaatcta tttctttctt
    11761 ctttgcggtt acataccaat acccaatcag tgaatcaatg actatatttc cactgttaga
    11821 aatggcagct atagccattc cactttcttc cataatttca tttataaatc caataatctt
    11881 ttcatgttgc ctgttttctg cataagcaag gatggacaca agattatttt tcatattatg
    11941 tttagcatca cgtaattgaa gtattgaaat ttccctttcc tgctgatgcc gttcacataa
    12001 ttcaagctgc tgttcatata cggaagccat acgtcttaat cgtaaatcat cggctaattt
    12061 catataaatg taaaatataa gtatattcat taccagcaaa ataattactg taattgccga
    12121 gttaatacga gtatgattat catttactgt aaatccaagc ataaatacat tgttcataat
    12181 gtatatgctc cccatcggaa tcaaaacgag cataatgctg tatcgaaccg acagttcttt
    12241 aatctcatca tctgtgaata ctttcttcag tgcaataatc actgcaagaa aaaatgattt
    12301 agaaacaaac gagccgatag gctgaataga agcatattgc tcacaataaa tcatcaatac
    12361 ataattactc agggtttcca taagcatcca gattgcatta aatgtaatca caaacacgca
    12421 cttattccac cacataccct cataagtgat cgtaactgca aacaatgtaa caattactgt
    12481 aactgcaata tttacataag caggaagact aatgatagtc gatattccaa actgccacaa
    12541 aacaaattcc gtcaatccag ccacccataa ttttttactc ttttttcgag caaaaaatat
    12601 atcaaaataa taaaagaaca gatatactgc ataagcactc agcaatatat ctgctccgta
    12661 aggcaaagcc ttatctatcc acataatatg tatcctccat cgaacaatac tgctcgctga
    12721 taagctttct tctgtcttca ctaatggaaa tcttttttcc attgtccatt actacaaaat
    12781 cataggattg tccttttata tgcttataat ttacgagaaa agactgatga acacgtaaaa
    12841 aagagatttt acataccttc agactgttct ctatctcatt taatttccca taaaactcaa
    12901 aagtttcttc tctagtcaca ataaacacct tccgtttact gctctcaaag tataaaatat
    12961 ctcggatcaa taccttatga ttcatacgtt gataactata acgaaagtaa aaatctccac
    13021 tatttatgtc ttcataagct gccataaaac atgtttccat ttgtttttca cttactggct
    13081 ttaccagaaa ctgaaatggt cgaactgaaa aagattcttt catataattt tcatgactgg
    13141 taacataaat aatcaaaaca tttttatcat atttcctgat tcttttagct gttgaaatcc
    13201 catcctcgtt gttcatctct atgtctaaat aaatgatatc gtatccatcc cctgctacaa
    13261 ccgaatctgc caggctttca ccattccaga atacttctat atctacatca gcaaaatttc
    13321 ttttcgctat tttttgaatt atcatttcta tctgccctgt tgtttgaata tcatcatcac
    13381 aaatcgctat attcagcatt cacatcaact ctcttctatc agtttattgt ccttttttcg
    13441 cttttctccc accttcttta ccgtctgcat aattgaccat atcatttctt tgtcatacga
    13501 atctaaatcc ttatatatct caattaagtc ataatactca tctaatgttt cattcatttt
    13561 catctgtctc tgcaaatccc tttttacatc tgaaactccc aaaagataat cagtagttac
    13621 attgaaatac gttgctattt tcttgagaat atccaccttt atcaatgtga catccctctc
    13681 atatttacta agcatttgct gagttattcc taattctgct gcaagaattt cctgtataag
    13741 tcctcgtttc tccctgagct gttcgattct actctccata attgattacc tcataattat
    13801 attgtaattc tatgctaccc taattcatgc ggcgtaatac aaataatgag agtaatcaat
    13861 tacgtcatta tattttatac agagatagta ggattattga aggggaaatc ggtaattgtc
    13921 agtaaaaatt tatttttttc atacaggtta tcagattttg tttctgtacc cgacgtgaga
    13981 atcaatagat aatcttaact tcctgataat ttaactctcg attgcccaaa acccccatga
    14041 atagtagatt tgcgagtatt ttatatgtta attctcgaga ggtaattaat tctcttatca
    14101 ttaacgatac aatacgcaaa atccgcataa ataagccatt ctttggaaac gagagttaat
    14161 tttacaggaa gttaagagat aacgatccaa ataacaccta acacatctta atcacttttt
    14221 tcaaacatgc gacaatcagc aatcgcctcg taaatattat aatttcaaca taccacataa
    14281 aatacatcca tatatccaaa tgtaatttct tcgattgttc atgtcattat tttgctttcg
    14341 acagtaggtt ttacttataa attattctat gaacgttttc ttgttattat aagcgtcaaa
    14401 gcaacacttg cctttgagaa ctaggtttga gtaataattc tccatatatt ggcattttat
    14461 aaaagtcatc tgataggatt tctcccagct atttagtaaa tatcaaattt tttgcctctg
    14521 ataaatcatt ccttggaaat aagagcatgc gttcacatac aaacgaaggc gttgaaggac
    14581 ggattttcac acaatttatc gcattgataa tccgaaacaa aatttatact gcattacagg
    14641 aaaaaaatga aaaacttgag agtaaacaga attatatgac agttccagca gtaatcaagg
    14701 aacttgagaa gattgaaatg acacgacaga cggataatgt ataccggttg gatcatgctg
    14761 taacagcaaa gcagaaaaaa tcttaaaggc ttttgggatg aatgaaggaa atattactta
    14821 tcgggtcgga gagatcagta atacacttaa gaaatcaaac attcagaaag aaagacggta
    14881 aatatggtac gtgagattaa cgcagaacta ctggatacta aaattgaaaa agacagcaag
    14941 atctggcgaa agcaaaacat cgatatgatg ctgtggcagc aacattaaaa gatctgttag
    15001 atttgcggga tgcacttcgt cagaaaaagc tattggatgc tatagcacaa agcggacgga
    15061 gctatgaaga aatcaagcag tacctacaca gtaaatctga agaggtgtga tcaaatgtta
    15121 acggaatact attttgcagt caggtatgga gatatcatta ttctgctcta tcatgaagtg
    15181 tatgactgaa gtacagattc agggtgccaa taacatgtaa atttccagcc taagatgctt
    15241 tagggctatt tcaagctgga aattaaggtt atccttatat ttctattgaa aaactggcta
    15301 aaattaatgc atcatgaaaa agatgaggat aaaaatatcg tgaggataac cctgtggcaa
    15361 taaaaatttt ttcaaatccg acagcatgta gaagcccccc caaccttatt tagaagttct
    15421 tctgtagctg tatttgatat ttcaattgaa acagatcctc ttcgaataac aacatccggt
    15481 ttaaaaggac tggcagatga acttgtgtga tcagtcattt tgatttcaac gaaatctgta
    15541 gttgttggaa ctgaattttc tttaacagct ggcgtcaagg tgttctctaa tgtagagagg
    15601 tatgcttctt ctcggagaat tcgttgccag taaaaaaatg atttatctga aataccatgc
    15661 tctcggaacc aagtcatttt gggcattcca ctagcaagac attctttgat gatatttgtc
    15721 cattgttcac atcgaacttt atgagttatt ttatccatga gataatttct ctaaaaaatc
    15781 ttagattttt caaagtaatt atctcatgaa aactagcgaa aatcttagta cttactattc
    15841 accgtttact cctatcctat ctttttatgc caataaaaaa gctttcttcc ataaattatc
    15901 gctcttcttc tctccttcaa gaagagagag acatacgccg gtcgttcctt ctaacagtcc
    15961 acatacatca tatggtttta ttttctccat tttattgtca agctccatat ttttaaatcc
    16021 atatatataa tccggattat aaaaatcaat tattttattc ttcaagagtt ccttttctaa
    16081 agaaaaaaac tccttttgta acaacatttc taccgaattt aatacttggt atagaccagc
    16141 atatccatga caaaatgtag gtgaaaaaat acctttaata ttgttcattg taagtctcaa
    16201 attttctatt ccgtaatcaa tcaaacgctg attgtctaaa gcattaccgg ccgatacaat
    16261 tgcataacat attcccggat ttccataaca ccatgcatct cgccgaataa tattttcatc
    16321 ggttaatttt ttgtttacta cttcatcaaa atctatctgc cctttccaga aatcacgttc
    16381 accatcattc aacttaaaat caaaaaggaa tttaattatt tttattatag cttcttcttg
    16441 tccatccaca ataatcccat tagccatcat atctgaaaga attattaatg gtcctgcaat
    16501 accatgagat aaactggtat tgaaattgcc ttttggataa agatcttgtt ctaattcact
    16561 aaattggttt tgaaccggaa tataccaacc cggaacaact tgaccttgaa tctcaatgtc
    16621 tttagtcaaa tttacaagaa tctccaatcc tcttgtgatg acattataat actttctttg
    16681 atttctataa attcctagat aactcaaaac accgctcagc ccttcaatta catcgtaata
    16741 gagtgaatgt gtcccttcct cttttactat attactgtat gactcttcaa accgatttag
    16801 aatatagtca ttcaacgtat ttagtaattt gttatagttt aaaaaatcat tggaaacact
    16861 agctactgat agagccacac cggcagcacc tgaaaacata gacagacttt gaaatccctt
    16921 tttatttagc tcttctacca ttagtgataa ataattatga gcaaatcgtc cccatttgtc
    16981 ttcttttgga caacattcca ttaattttcc gtacaataaa caaatccccg gaagaccatg
    17041 actcaaagta agtggtgaaa atgcttcaaa ttctattcct tcccaagttc gttggttttc
    17101 ttttctcccc attattttta acattctttc gtaatcactt aaatttgtag caatgttctt
    17161 ggtcatagct aaaatatcgc attccatttt cctacatgtc ctctctttca tatgattccg
    17221 ctttatatag cttttgatat gtcatacagt ttcgcagtag ctcatcatgt ttgcctattc
    17281 caacaatttt gcccttatcc ataactataa ttttatctgc catttttgct gcattaaggc
    17341 gatgagaaat aaaaacgcca attttatctt ttgataattc aaaaaacttt tcaaaaactt
    17401 ctctttcaga tactgtatca agtgcagcat ttggctcatc taaaatataa aaagatgcat
    17461 ctctaaaata aactcttcct aatgctattt tctgccactg tccttgagac aattgacatc
    17521 catcttcaaa ccaatttcct agctgcaaat ccaaattata acttccatta tccgtttgca
    17581 aaaacttagt ttgtaacttg tgaagcattt gaaccatttt ttcatcattg tttagatttt
    17641 gaatatctcc aaagccgata ttttccctta aactaagctc atattttaca aaatcttgaa
    17701 ataaaacaga catctttgat ctataacttc tgatatccaa atcttttaac gatctaccat
    17761 ttatcaatat ttctccttct tcgatgttat agagcccggc taaaattttc aaaaaagtgc
    17821 tttttcctga tccgttagga cctacaagag cgaccttttc gccttgtacc aatgtcagat
    17881 taattttgtc caatactttt gtttttccat tatatgaaaa tgaaagttct ttaatatcta
    17941 ttttattaat tggttccttc atcactattt tttctgaact atcttctttt acacagtaat
    18001 tcaaaaattg aaaaagcata tccatataca atgtactact atatactgta taaatatttg
    18061 acattattgc ctgagaattt gtttgtacta accctacact cctaatataa ctcataacat
    18121 taccaacaag aatctcacca acatatgctg acattatagc cactcctata atgattgcac
    18181 tcacaatttg tatagataac tcatatagaa tattgaataa cgtttttctt ttcaggatgg
    18241 aggtgttttg gcgaatgaaa agagcactaa tactccaata ctttttaaga aaatagtctt
    18301 tcaaatccaa taaggatatc tctttgaatg aaaaatcatg cgtcagtaaa tacgttagat
    18361 accatgtttt tcgttcatct ttagctctat tccacattat ttcaaattcc tgttgcccta
    18421 tttttaagta atatagcatt gatataatag gaactacgag taatagcata gatatatatg
    18481 gattccatgc aaataataaa aaggctgaag atagcattgt tacaaccgaa gtaataattc
    18541 ctataattgc aatcataatt tgatatggct tatatgccac ttctccggtg attttttcaa
    18601 ttttatcata catggcaggc gtctcaaaat cttttaatgt cagttttgta cacttatcca
    18661 taatcaagta attcaatttg tactgaagaa catattgaaa tttgctttca atataatctt
    18721 ttgcttctcc aagaatactt cctaaaaatg aaacgataat ataaatcgta aatagaatga
    18781 tggtatatcg taatggtgag cttttcttaa ctattgagtt aattaattcc tgtgataata
    18841 ccaatgttat tacaggaaaa gctcccgcta tcatacttag cattactata agtgtaaatc
    18901 cttttttatc aacttttcta attatagtta tagttttagg tatctgcttt aaagccctcc
    18961 aaacttcttt aaaacctact ttcttattat tcatgatctt cattcctctt cattatgtat
    19021 cgcttagcat acattatact ttcagaaaat gccatcaatt ttctctccag ttcacgatcc
    19081 gttccaatta ttctattaca atgtagatga attacgcttg caactatact atttttaaac
    19141 aacggatcct ggtttatatt gttgatttca tccctatatt tattaagtac aactgttctc
    19201 atatttaata aattatatag agaagttcct tcttcattac ttaataattc tttccaatca
    19261 ttctcacacc cgcataatga aactaatctt tgctttttct ttttaaattc cgacataaag
    19321 tctgatgtat gataatttat tgccagaaaa ttcatttgtt cttcaaaggt ttcataaaat
    19381 ccctgagtat acataatgat tgagataatt gctatatcct cctgatcaat agctaatacc
    19441 cctaatcgct tcattctgag gatactttca acaataaagc tgtcgataaa aaatacttgc
    19501 tctgcaatat ccataagatg caaaccgcca taccgttcaa tctctctatc atatatagaa
    19561 atttttaaat caccaattat accatcatcc aataattggt gctgccattt aataattagc
    19621 ggatatatct gtaacaatac ttcttgtgtt ccttttatcc gtagccgtac atgtggttta
    19681 ggatctacat aacgcataaa gaaataatct acatcatatt tctttttaag ctcttcgcag
    19741 aaatccatga tatcaaaggc aatcaattca tcttcacgat tactattgca atataggtta
    19801 aaatataacc aattttcaaa aggtaattct aaatgtttct ttctttcaat aatcactttc
    19861 tccgccggat aaatattctg tagttccttt tcttttctga aaagaggaac tacaatttca
    19921 gttgtatgac ccccttcacc actataagta atattttcac cagtttcagc tctttcaaga
    19981 atcagatcac gactaccatg tttcttaaat tcatcaaaaa taatcctaat tgacaattct
    20041 ttttttaagt ccagctttat tctgttatca gcttctgtta aataaatatc atccggtatg
    20101 tttttatctt ttataagttg taaaaacttg catttaaatt cctcaaaatt tttcttttct
    20161 aatcgcatct cactaaggtt taatttccat ttttcatttt caattacaat atcctcaaac
    20221 tttatggctg gtacatggcg gaactctgag aatatatatg tccaaggaaa ttctgaccaa
    20281 gatctcttcc cttcatgtga tatgtcctgt aaaaacctta atatattagg atttagcatc
    20341 ggattgtaca tattattaga ttcaaagacg actaatttct ttgttttata atctcttgcg
    20401 taaaacaact cattaaaaac ccctatggaa atatctttta tattgataac atcagtagtt
    20461 cctttatctg ctgctgtaaa aataaccgtt ttcttttctc taaatgtgcg ggttctaaca
    20521 atatttccat ttctggccgg tgcaggaaga aacccaatct cacacatttc aatattatca
    20581 tcacgtaatc ttctttcttc cttattaata tcttccaaca tatccgcaaa ttcatcggag
    20641 attgtggaga atcgaccaaa agttttacca gctacaagcg aaccacaatt aggacctaaa
    20701 caaagattta attcatcatt tttcttttta agttggaaat acagctctaa cgatatgggg
    20761 acttcgtccg ttttaatttc tctttttaga atcccctcaa tttcgtcctg ttctaaagtg
    20821 atagatgttt tattggtaat agcagattca tatttattca gcaaataatt ttttaacctt
    20881 aaattgtaat taggtttagt agaatcttcc tcgaaaaaat cattttgggg attaagatat
    20941 gaagtcggtg ctcctattcc aatatttgaa tctaacattt ctaataatgg tacttctctg
    21001 tcaactccat acttttcaat aaacttattc ctatattcat ctaaataagt gtgactctca
    21061 ttcttatcat tgcttatata aacaaaaaag cttgccaacc tattaatctt atttgcaact
    21121 gttgatttta tttcaaactc agcattttca attactgtat ctacttgtaa gtaagatgag
    21181 caagaataca gtagcttcat tttagatact attttatcgt acagagttat cccttcacct
    21241 actggtaaat tcatgtagga ggtacacatc tttcttatct ctataatatt tcctgcttcc
    21301 tcaaaaagcg cactttctct taatcgctca attacatatg ctatttgatc tcttgaattt
    21361 aacgacggcc taaggtctga aattagtatt tcttttgaaa taagctcatt taaataaaaa
    21421 gtaacttttt catttggcac attaggatac tcttcttcaa tgattccagc aatctggtta
    21481 tattctttga attcctggca tgactcataa ataatttcaa agaccctagt cgctcttaca
    21541 ctaatttctt ctatttcctt ttcagtagaa tataaaagaa tagctctatt tcctttaata
    21601 taacatgcat catttatttt aaacctaagt ctttgtgact taatcttttc taactgagat
    21661 ataaatccaa aaagccattc tgaatcaata ttgactttct tttgatattt agcccctgat
    21721 acgtcaaaag tatcactatc tccgaatttt cccagaccga cacctgaaaa aagcccaaat
    21781 ggtgtagttc tatttttgct cctaatcaaa tatttcataa ttgaattttg gaagtttact
    21841 aacttcttct cagataattt ctctggattt ttaatgtaca aatccatcat atcaactaat
    21901 gcaggacttg ctatactgac tttttcacgg aactttgcat ctaaacacgc attttttatc
    21961 tcatcttccg taaagtcaag ttttctctct acatcagttg gtatacgaaa cataaacttt
    22021 tgagtattat agtataaatt tttcatttct acctcctaat ctgttataag tcaactataa
    22081 agtggaatta tcaaaaaaat atcaagattt tttgaacata ttcctaaaat atgatatact
    22141 taagaaaaag ataaaggcgc cctttccatg aaaacaaaag aagaacttct actttctgtt
    22201 aaggaagaca ttgaagcatt tggaaaagac aagttagtgt acacacatat gtcattgcaa
    22261 aacgaaggaa ccatcttata tggctactca tatactcccg aaggaaaatt tatagacgaa
    22321 gcatcattag aagagttact tattatatta gaaagtgaca cggatatgta aaagtaagaa
    22381 aaggggatga ccaaatttac ggtttccccc ttttcctcta tgtgatcggt aattttatgc
    22441 ttaccacagc accatgctct ttagaattgt atagttccaa ttccccttca caagattgaa
    22501 taactttatt cgcataagct aggccaatac catagtgaat tgaatttcta ttattatttg
    22561 aagtaaaaaa taatttagtt ccattctcaa gaacctgact actaaactct cctttttcat
    22621 tacatatggt aaatatataa gaatcatctt tttttccaat aaaacacatt attttgtcac
    22681 catatacctt atattctatt gcgttatcaa taatgttaaa aattgccctt tctaaagata
    22741 tgtagtctat cttaatagtg cccctcactt tttcaacatt aaatttaatt atttcttcag
    22801 atccgctgat atactcttta atctcagaga ctattttatg agaaaaactg ttgcagggca
    22861 tactttcctt ttcgtgaaaa tcaattctat cagctttcac atatttaatt aataaattaa
    22921 tgtattcctc catcttgccc acagctcccc aaatactttg cagatgagat aaactgtact
    22981 catcagatga ataacatttt aaaagctctg tatttccact gataattgta agcggtattt
    23041 ttatatcatg agccaatgct gctatttcct catttttttc attttctatc ttccaggttt
    23101 gatacaatga ctcttttaat gcatccctca tcttaattaa tgctgtaata atattagaaa
    23161 attcttttat cttactttct tcgtaagtga aatccagatt ctgtttttct atttccagcg
    23221 taattttctc tatcttttca aaattatttt tccagatgcc aactaagtgt aatgtcataa
    23281 tatacacata tagtaaaaac actaatacca ttgtgatata cgacaaattg tcataatcta
    23341 tataattgaa aattttattg tcagagttaa aacgtgcttt aatattatac tttataacgc
    23401 aatattcttc tgttctagca attactgagt aaacataatt cccttgaaga ttactttctt
    23461 tccctaataa tattttttta gttacttcta tatctgattt attcatagtc ccacgttcat
    23521 aattataatc taaatcaaag attgaatact tacttccata tggtaaatca ttatctgtta
    23581 tctgttgtat atcatctaaa cgctttctat tctcttccaa aatagtttcg ctataatttg
    23641 ctggaattat cactccgcat tccacaaata tattagttaa agccaaccaa cagattatta
    23701 taatcacgat tcccataaac aattttatca agtacagtaa taactgtctc ttcatcgtta
    23761 ttattttata tcccatttat aacctatccc ccaaatagtt tttattggat caagaccaag
    23821 tgttttgaac ttttttctga ttgagtaaat aaactctgtt atagtcctta attgtgcatt
    23881 ggcatctaag tcatataagt attcatatag ctcatctttt gaaaaaatct ttccgctatt
    23941 ctgaacaaga attttacata tgcgaaactc atttttcgtt aataaaattt caccattatc
    24001 taattttatt gagtttgaat cttgattaaa caccaatcca ttgattaaaa tcccgttact
    24061 cccatttttc aaatttcttc ttaatgcaac tttcactctg gctactaact ctctgatact
    24121 aaaaggtttg gtaatataat catctgctcc actcatcagg cctttcactt ttgctccttc
    24181 actagactta gcagataaaa agatcaccgg acatgttatt atgtttttta ttctctccaa
    24241 aatttcataa ccatctaaaa acggtaacat aatatccaat aatattaagt caaacccttc
    24301 aaattcacca atattagtat tgtcaacata gcttcttgtt tccactatat aatgttcatt
    24361 tttcaaaact tcttgtacta attctaaaat cttttcgtca tcgtcaatca caagtatatt
    24421 ttccattatc tgctccttta tgtttttact aactaataat aacaaaaatt agtaattaat
    24481 cacccaacat gtaaaaaata ctcatttact cgtaaaaaaa gctctattat caaaatagag
    24541 cttttttatg tatgtacact aaaacagatt tattgaccct ttaatttaca tgtgcatgta
    24601 agctgagttt ttggtggaca aagaaatcct gttaggcaat tgggggtaca aaaagagtgt
    24661 tgacttgtaa tactcgcagg tataatatct cttcttactt ttttttcgat aatatccaaa
    24721 tcaaaatcat caaattttgc catcttcact tccaaacttt atttacctgt gatatggcat
    24781 ccgcatgttg ctgtcttaag tgggcatgtc ataaggattc ctgtcgggca tcctggggta
    24841 catgctgatt tgctcttata cttcggctcg atcccaccct gtgctgctgt ctttgttaca
    24901 tccaaatcga aatcatcaaa ttttgccatc tttttttcct ccgtattctt tattatttac
    24961 ctgtgatatg gcatccgcat gttgctgtct taagtgggca tgtcataagg attcctgtcg
    25021 ggcatcctgg ggtacacgct gatttgctct tatacttcgg ctcgatcccg ccctgtgctg
    25081 ctgtctttgt tacatccaaa tcgaaatcat caaattttcc catttggtgc ctcctttctt
    25141 tttgataaat tagttataca atataaaaat cagcaaaata tcaaaatcgt tcctaaattt
    25201 aatatatttt tttacaatgt cgtttctagc tatattctga atacgcaaaa tttagaaatg
    25261 gagtagaagc aattccctct cttcttcgtc gaagatatca tgtggacaag atacctgtgc
    25321 atggcaaaaa acgtacccgg ttattcttcg gatttaaaat agcagcatta gattttcaaa
    25381 agctattaga ttatatcaat agcttggatt cgtatgcttc aaataagaaa acagcataaa
    25441 atcaatgaac cacagtttca aaatatcaat aaattatagg cgcaaaaatt atatctttca
    25501 caaattcgtg ttaaattttc aaggtacaag caaaatcaaa tattaaaatg ggcttttgac
    25561 accctaatcc tataaagtaa aaaaactctg gtgtattcca ccagagctaa cctgaactat
    25621 gaatttttcc tatataataa tatctacttc tgctcctctt ttatttttta attctacttt
    25681 tccaccatgc tgtgtcacaa tagaatttgt aatatataac cccattccat aatggtgttg
    25741 ataatttcta ctcttatcat ccataaaaaa tctttctaaa ccatatttta atgctgccgg
    25801 cgtaaaacca ggacctgaat ctataatact aatcttacat tttcctttat ccttcgtcac
    25861 gttaaaaata atctccccat gtgtaggaga atgatctacg gcatttgata aaacatttat
    25921 aatcgccctt tccattaata ctgtatcaat ctctatccta aaagattcat ccataattgc
    25981 aattattaaa ttcatttttt tcattgcaac tacagactgc atctgtcctt ttatactatc
    26041 aataaacttt ccaatagata tgctttctct atttatcgga atctcaccag tattcttgga
    26101 tagatcaatc aatatagcaa tgtaattttc catgcgttta gagctctcta aaatatggtt
    26161 aatatactct tcttgctcct gattaatatt tgtttcagat aataaatcag cattaccacc
    26221 tatgatcgtc aacggtgtct tcaaatcgtg cgctaatgcc gaaatttgtt ctttctgctg
    26281 acactctata ttccattgcg ttttcaaaga cttttttaaa ctatttttca tattataaat
    26341 agattttaat atatcattaa attctattat cctcgatgat gaaatattaa attccagctc
    26401 ctgctcttct atttttgtag tcgcatccat tactggcttc aactcttttc ttagttcttt
    26461 tgcaaacaaa aagaccataa tactaaatac aaataaacaa tttaaaatca ttcctgcatt
    26521 aatcaaaata tctggagatg gcatatgtat atctaaccat atattggtga aatgagaacc
    26581 aatataatat tgtaaaatac agaattcttt atctcttgta actaaaataa attgtttacc
    26641 tgatgctgtt ttctcaaact taccatttgc atatctcaat gcgtcttttt gttccccatt
    26701 gctcatatta gtatttaaga tatcgaattc tttgctaatt attaagtatt ttatccctgc
    26761 tggaatattc ttatagtcag gatttttttc tgtttctaaa atttttgccg ttttctcagc
    26821 ctgtatctca ttataatttg caacagttat atatcccata ttacttgcaa gtgttgccaa
    26881 gaccagcggt aaggcaatac tcactccagc tcctataatc aatgacaata taaactttat
    26941 aaaaaaaaac tttagagaat actgcctttt ttttattttt actcccattt atatcctatc
    27001 ccccacactg tctgtatagg attcacacca gcttcactta gtttcactcg tatattttta
    27061 acatgaacaa ctattgtatt atctgctgat tctccataaa atccaaaaac tcgttcatat
    27121 attttctctc tggaaaaaac gtgtcctcta ttctgtatca gcaattcaca tattttgtat
    27181 tcgctatgtg tcaaaggaat ttccttttca caaaccaata gcttttttgc tgacaaatca
    27241 aacttaatat ttccatcttc tgaaaataaa taatcatgat tttctctgga ctctcgcctt
    27301 aagtgtgctt ttacacgagc tcttaactcc ttaatccgga agggttttgt aatataatcg
    27361 tctcccccaa tacctaaacc atataatact tcgtcttcca gtgttttagc tgtcagaaat
    27421 aaaattggtg cattgaatat gtcacggatt tttttgcaaa atgtgaaacc atcaatatcc
    27481 ggcatcataa catccaaaat caacaaatta tattgccgca gtttactaac atccaccttt
    27541 tttgcagaag tcaaagtgtc aacagcaaat ccatcctttt ctagtccacg tttgacaagc
    27601 tcaagtattg cctcttcatc atctataact agaattttaa tcaagatatc ctctcctttt
    27661 aaaattttta tttgttagat attatagtca caagtttgac ccatactaat cttttaatat
    27721 agcatataca catttataat taatttcaac tgccaaacta tccttatcct ttccaataac
    27781 ggtgtatacc gaatcatata tccaagtctc ccgtttttgg tttgacagtt cgcccggaat
    27841 tatatcaata gcatttaact catcatgtgt aagttccctg cctgtttctg catcaaaagt
    27901 aatatttccg gataaagtac atagataatc gcctattttt tcatttggta caacttgatc
    27961 tgtaatttga tatgttttac cttcccaagt caaattcctc acatcttctt tatcaatttg
    28021 tggtaaatca ttttctatat ctttggtgtc attttgattt ttaaaaatta tctttaaatc
    28081 accatctttc gcattttctg atggaattgc tttatggaaa tcgttatcta catctacaac
    28141 taaattattc atatccccct cattttctgt cttatataca ttcaaatatg gcacataata
    28201 tgcggtacca tctgtatgat ctattaagtc gcttaaatct cctactacgt tgactcccat
    28261 atcacatttt tttagtatgt tataattttc atcaagtgca acatactttt gaataaatcc
    28321 aatccaatca cctaatgaat tcttatccac tgtattattt aatattgtgt attgttgtcc
    28381 attatatata aatttcgttg catctttctc gtctaaataa cattctgttt taccttggtt
    28441 ttctaaaact gtctttttag cagcacaacc tgaaccaatg atcattatag atatcataca
    28501 aaataccaga atcacccttt ttattaatat actattcttc ataatttttt cttccttccc
    28561 atttctcaaa ccatatacaa aacaccaaca ataacacaaa tgttataatg ataactttaa
    28621 atataatatt gggttgaaga gtagagagtt gagtgttaaa ttgcaaaatt tcttgtctac
    28681 acatatttac tgcccacgcc caaggaatat attcccaact aataactaac ttcaacggaa
    28741 gattgctaaa caaaataaca ataaggcttt ccaacacccc tgttataact gaagctccaa
    28801 gccctgattt cagagataac caaaaatgga ttatataagt tacaatgtta cctaaaacta
    28861 aataaacata actatacaat actgtattaa gaacagaaat actaagctct tgatccataa
    28921 ctgctactga aaataaaatt ggtaaaaaga gaatcacaat ggctactgca cctattccta
    28981 agaatagaat taactttgca ataattaatt tactcttact ctccatacct acaaaaagtg
    29041 cctgaaaatg cccttcttct tctaagttta tacctagact aacagcaata gaaattgcaa
    29101 gagggaaaaa tgctgatgtt gcctgtaaaa ttagattcag tctttgtgtt atactttgtt
    29161 gtcctgaata taagtgaaaa tacattgcaa ataataaccc tcctagaagc ggtacaatta
    29221 tgtgcaacaa aaaaataggg gtatgtcgta attttacaac ttccgactta attgcatacc
    29281 aaagactttt catccttcca cctctctgaa tttttttgca gtaataataa cagttataat
    29341 aaatagtaaa acagataata agagtccaat agtaaagtct aatgaatctt ttgaggaaac
    29401 ggtcgtcatt gttccgttta cgtctaatcc gataatactt ttcatagatt ttgagaccca
    29461 actataaggt atcaagaacc atagatcagt attagataac ggagaaatag ccaatggcaa
    29521 catacaatta attataagcg gcaaaagtat acctattctt ttattaaaaa aaagcaaaat
    29581 aggaatttgc cataatgaca taactacaat acatatactg ccaagtaata attttccgtt
    29641 agatatttgg caaatggccg gtgcccatat tttcattgat actgccggaa gaactaatat
    29701 aatacctgtc aaaagcatat accatgctat aactaacact cgagcatacc aagcattttc
    29761 taaatcaata gatagggtat aaaaggtgtg atagcgtaca cttttttctt tcttctcaga
    29821 caatgaacag tatatggcaa ccgtccccgg taagagaaat gtataccacc aatatatagt
    29881 ttgtgcttga aaatttctaa ttccaccaaa tataacagct acaaaagctg taatgatggg
    29941 taccacaaat attaattttc tgctgaaaga ccgtttatat ttcaaatttt ctgatcttat
    30001 atatctcatt aaataatctc ccttctattt ctttttacga tgtccataaa caaagcttca
    30061 agattatctt ctttgttctc tggtgcttcg tattccaatt tcccattaca tattatccct
    30121 atataatctg caatctgttc cacttccgat agtatatggc tagatagaat aactgtcata
    30181 ccttgcttcg gaaactgcct tattaaattt cgcagctctt caatacctac aggatcaagg
    30241 ccatttgtag gttcgtctaa tattagtaat ttggggttat tcaataatgc tattgcaatg
    30301 ccaagtcttt gcttcattcc catagaaaac tgtcctgctc tcttttttcc tgtaccagtc
    30361 aaacctgata tttcaaggac ctcgtcaata cgaccatccg aaatatttaa cagctcagtc
    30421 cttaccttaa ggttttctct tgcagttaga tttccatata aaggaggtgt ttcaatcaat
    30481 gcaccaatgt ttgataagtc actccttttc cacggatgtt tattaaaaat aatacttccc
    30541 ctggtaggtt tcaagattcc agctatcatt tttaatgtag tagattttcc tgcaccatta
    30601 ggtcctaaaa ggccatagac agaattttca ggtacattca ttgaaatatt ttgtattgct
    30661 acctgattct tgaatttttt tgttaaattc tctgttctca gtaatgtttc catattatta
    30721 tacatctcct tttaattgat ttttttagta tactgattaa ctataaagat tttctaaaga
    30781 ttaaaaaatt ttttatattg taaattgcat aacaaaaaag atagaacttg taaggtccta
    30841 tccttctcca cataaatgta tccaaatttg cagcattcaa caaatacccc aatatcagtt
    30901 gacattcacg gttttcttac atgctaagat gataaacaaa tattccataa ttttgactgc
    30961 tgatatgtaa agcagaaagg ggacatccat ttattggata tcccactttt taatctctca
    31021 ttttgttctt ccatattttc tttgaattca agataggatg aaatcatatg tttcaccgct
    31081 tttaattgtt ctggcgttaa agtgtacaat aattcaagaa catcctgcac atcccttaat
    31141 ttccagcctg aaatagccct aaaagcatct caggctggaa attaagggta ctgtacagaa
    31201 taggactggc tcttcccaat cgtagctcct aaagaagcgg atatatctcc tacactggta
    31261 tatgatccac taattgtgtt agtcactgta tctgttttat ttacagaaac tgtacctggg
    31321 ccggcaccct gaggtcccaa tctccatgaa ccataagttg ttccctgatt cgtcttacta
    31381 tcgactttcc aataatagta tccatccgtt tgtggctgta ttccatactc agttttatca
    31441 gatagcaaat ttacatgctt tacttcactg tttttatgtg gatattctgc agccattact
    31501 tttacaggca acattgtcac aatactaagt accaacactg tcaaaatact aatcattttt
    31561 ttcatcaaat cgcctcccta tatagtcaag tcttttttcc ttatttttca agggattttt
    31621 agttccatat ctcagatgaa tgagccaag
//
