LOCUS       NZ_JADNBM010000019     21446 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Sellimonas intestinalis strain 1001217B_150727_G3
            NODE_19_length_52038_cov_61.4076, whole genome shotgun sequence.
ACCESSION   NZ_JADNBM010000019
VERSION     NZ_JADNBM010000019.1
KEYWORDS    WGS; RefSeq.
SOURCE      Sellimonas intestinalis
  ORGANISM  Sellimonas intestinalis
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Sellimonas.
REFERENCE   1  (bases 1 to 52038)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 52038)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.75x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 02:59:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,087
            CDSs (total)                      :: 3,015
            Genes (coding)                    :: 2,958
            CDSs (with protein)               :: 2,958
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 5, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4 (16S)
            tRNAs                             :: 60
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 20 of 57
            Pseudo Genes (incomplete)         :: 33 of 57
            Pseudo Genes (internal stop)      :: 13 of 57
            Pseudo Genes (multiple problems)  :: 7 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:35:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 12727
            Orig. end                         :: 34173
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADNBM010000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21446
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21446
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21446
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11446](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11446
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(718..734)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.73"
                     /tool="antismash"
     misc_feature    complement(720..733)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            1085..1597
                     /locus_tag="I2A62_RS12810"
     CDS             1085..1597
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002567868.1"
                     /locus_tag="I2A62_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ferritin"
                     /protein_id="WP_195243570.1"
                     /transl_table=11
                     /translation="MLDAKVAELLNTQINKEFYSAYLYLDFANYYTEEGLDGFANWYNI
                     QAQEERDHAMLILKYLQNNGCKVTWEAIDKPDKRYHSFADPLHAGYEHEKYVTSLIHNI
                     YDAANQVKDFRTMQFLDWFVKEQGEEETNAENMIKKYELFGSDPRALYMLDGELGARVY
                     TAPSLVL"
     gene            1652..2242
                     /locus_tag="I2A62_RS12815"
     CDS             1652..2242
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006974 - DNA damage response [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015515064.1"
                     /locus_tag="I2A62_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SOS response-associated peptidase family protein"
                     /protein_id="WP_048621022.1"
                     /transl_table=11
                     /translation="MCSVFYVGENMIQKMKHLTQEIDKEAEKVKLERDIHPTDRALILR
                     WGDHKIRLSGMKWGYPVIHGSGVLINARAESVMEKRTFAEGIRYHRAVIPASHFYEWNS
                     KKEKYTFQRKDRSVLYLAGFFDLIDNEECFIILTTEANASMRAVHGRMPLILQEDQIED
                     WLRDGKVTEEILRQVPMELVRTAKYEQMTLFPM"
     gene            2274..2939
                     /locus_tag="I2A62_RS12820"
     CDS             2274..2939
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014826.4"
                     /locus_tag="I2A62_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PHP domain-containing protein"
                     /protein_id="WP_053769449.1"
                     /transl_table=11
                     /translation="MKIEMHVHTSEGSSCAKAEAQEIVKAYGEAGYDAIVITNHFDPLL
                     LQEFGETDEQKIERYLLGYRKAREAGKRYGVKVMFGVEIRLEPGVEDFLIYGIDEEFLF
                     QNPNLCFLSQSEVFNRCHAYGAVFYQAHPFREPCVPQRPEYLDGVEYNQRPNSGNHNEK
                     LDVWRKDYPELRLISGSDCHDLDQVGYGGIEIEENVDNIKEIVAIMKKGNYRLITTPV"
     gene            3071..3604
                     /locus_tag="I2A62_RS12825"
     CDS             3071..3604
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016281313.1"
                     /locus_tag="I2A62_RS12825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6323 family protein"
                     /protein_id="WP_048621020.1"
                     /transl_table=11
                     /translation="MEQNWMQLLDQQNQLSRVMETNRTAQTYGLILSEQDAKLLLKERG
                     RALKKEKRVEFGEGILPKMIYEFCDCPYLNQEHYVETLVRLQDIFYLYKNEMLDEITDD
                     ELLHFMREQYETVCFGDLDYLEGTCLDIFAQAIRAGYRGYRVTDGRSEYGQFDEVKRWD
                     YELYLEALQDLCWR"
     gene            3610..4548
                     /locus_tag="I2A62_RS12830"
     CDS             3610..4548
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040016.3"
                     /locus_tag="I2A62_RS12830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6179 domain-containing protein"
                     /protein_id="WP_195243571.1"
                     /transl_table=11
                     /translation="MWYEMEELVPIVGRLARKYTSGDSTSISYEKAEQLMGAVLYCIRE
                     AGAQRKWAVTDRENLTAETAYLTGAACVEKKTKRALRLYHQILKNFDSYEQHCLNETIT
                     KGMPEYFRWYDPIFAPQETLLTLDYPVLEDLKDYTGIDCVERWLSRVKQEQQFLHCFPR
                     ADLIWMLEEYDEDYRDGMDNLCEMVLSVCVKQVLAGKSLANRVFGREEENRIRETLEQG
                     GARLLDEKIYPVLRKLVSKAGRDADALWFYLFPAIDSAFVRIQYTARHRGQEADDRVIE
                     IELQREVTYETETTTAGLQRQSAEPGAVDFA"
     gene            4478..5590
                     /locus_tag="I2A62_RS12835"
     CDS             4478..5590
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013799.4"
                     /locus_tag="I2A62_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkaline phosphatase family protein"
                     /protein_id="WP_195243572.1"
                     /transl_table=11
                     /translation="MRQRQQLPDYRDSLPNLAQSILREFGITEVGRESLKSLDPYLGKG
                     YQNIVVLLLDGMGSKVMERSLEGDGFFLRRKKADYHSVFPPTTVAATTSIRSGLQPCEH
                     SWLGWDCYFPQINKNVTVFTNTETGTSTPAADYHVAQKYCGYETVVEKINRHGGQAYEV
                     MPFEEPFPQTMEAICERIEELCRKPGKKYIYAYWNEPDKTMHETGCYSEETKRVVRGLE
                     EQVETLCRKLNDALVIVTADHGLVDTKNVSLTDYPKICECLKWLPSIEPRALNLFVKEE
                     KKDQFEQEFEKAFGGQFLLMTKDQVLESQIFGDGTEHPNFRGMIGDYLAIGIGDVTIFS
                     DREEAESMKGVHAGLLETEMQIPLIVEERA"
     gene            complement(5746..7104)
                     /locus_tag="I2A62_RS12840"
     CDS             complement(5746..7104)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018594603.1"
                     /locus_tag="I2A62_RS12840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_024733672.1"
                     /transl_table=11
                     /translation="MKRLSLKLKLTLLYSFFMTLLTCAALAILFSLSNKEILASTQNTL
                     KKQLHESLKDIEWEDGSFDLDSDFYNLDGGVYLSLYTENGDFLFGRIPYGFSLHPDFSD
                     GQIQTLSDAEKQWYIYDLSYRLNGYGLVFVRGISSVTDAESSFRITLRFAVIVLPLLVV
                     LTAVIGYLFTRRTLRPVRRITETVRQIQGDQDLSRRVELGKGKDEIYQLADTFDQLLTK
                     IESAFQREQQFTSDVSHELRTPVTVILAQCDAILSDASLPAEQRVSIGLIQKKAQNMAQ
                     MISQLLLLSRADQGRQQLQPELLNLSELTEMVCEEQAMLSEEKKIAITTQIEPDLFVKV
                     DETFYIRMLVNLISNAISYGKAGGHILVSCYEQSGFFVGQVEDDGIGIAAEDLPHIWER
                     FYRVDSSRSASGHSGLGLSMVKWIVEAHGGTISVKSSPGEGSIFTFLLPMKAE"
     gene            complement(7101..7775)
                     /locus_tag="I2A62_RS12845"
     CDS             complement(7101..7775)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440135.1"
                     /locus_tag="I2A62_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_195243573.1"
                     /transl_table=11
                     /translation="MRILIAEDEKDLNRILTARLKAEHYSVDSCKNGQEVLEYMAGAEY
                     DALVLDIMMPVLDGLSVLKSIRRRGCAVPVLLLTAKDSIEDRVAGLDAGANDYLVKPFA
                     FEELLARIRVLLRKPAEAPSNCLQTANLKLLLDTHQVFRGDTEIHLSGKEFSLLRYLMQ
                     NEGIVLSRDKLEQHIWNYDFTGGSNVIDVYIRYLRRKIDDGFEPKLIHTVRGAGYVLKV
                     AI"
     regulatory      8045..8214
                     /bound_moiety="magnesium"
                     /db_xref="RFAM:RF00380"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00380"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="The M-box (ykoK) riboswitch appears to function as a
                     genetic 'off' switch that is important for maintaining
                     magnesium homeostasis in bacteria; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(8166..8179)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.55"
                     /tool="antismash"
     misc_feature    8372..8388
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.7"
                     /tool="antismash"
     gene            8413..9747
                     /gene="mgtE"
                     /locus_tag="I2A62_RS12850"
     CDS             8413..9747
                     /GO_function="GO:0015095 - magnesium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015693 - magnesium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mgtE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006861887.1"
                     /locus_tag="I2A62_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="magnesium transporter"
                     /protein_id="WP_048621015.1"
                     /transl_table=11
                     /translation="MNRQILTDLLRKRDFKAVRSILEVMYTVDIAALLAELDDKEMILA
                     FRLIEKAKAAEVFAEMSSSMQAYLVEMFTEKELKELLDELYMDDTVDLLEELPANLVTR
                     ILEQVDREKRAQINTILNYPEDSAGSIMTTEYVDLRRTTTVREAMEHIKQTGIHKETIY
                     TCYVLENRKLIGIVSAKDLMTMDDDLMMDELMEKEIISVTTHTDQEEAVRLLSRYNLLS
                     LPVLDQQGYMVGIVTIDDAMDVLVDETTEDMEIMNALSPSEQPYFETGVFRHAKNRIVW
                     LLFLMLSATLTQTIIAHYEAAFTAVPLLVSFIPMLTDTGGNCGSQSSTLIIRGLALDEI
                     HFGDIFRVVFKEFRVAILVGAALAVVNGVYMVIRYRDPMLALLVSISLVATILIAKMIG
                     CVLPLFAKKLHMDPAIMAAPLITTIVDVCSIMVYFQVATHLLGLI"
     gene            10001..11446
                     /gene="ccpM"
                     /locus_tag="I2A62_RS12855"
     CDS             10001..11446
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0046500 - S-adenosylmethionine metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="ccpM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04068.1"
                     /locus_tag="I2A62_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Cys-rich peptide radical SAM maturase CcpM"
                     /protein_id="WP_195243574.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2e-16, bitscore: 52.0, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 7.1e-57, bitscore:
                     184.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5e-14, bitscore: 44.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9e-09, bitscore: 27.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.8e-09, bitscore:
                     29.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEVNKEPFIHLFSCSTGYYLYDVNTDSILKVTPDTYQRLEKREN
                     IEENEQIRKLKKYGYLKTSHVQISEHPVTKLLPSLYENRIGNLTLQVTQQCNLRCDYCV
                     YSGKYYTRTHSNKRMSFEMAKKGLDFLLSHSSACEELRVGFYGGEPLLEFELIKRCVEY
                     METQTKDKAVHYQITTNGTLLKGEILTYLIEKKFEITISFDGPKEIHDRYRKFAGSDKG
                     SYDTVMQNARYIKEHYHNFFISNVTFNTVISPEESYSCIGNYFKGEELFQDAVFTSGLV
                     KDEGKKEKNTVSDRFSEEYQYEYFKLLMSKLGKIRKENTSVLGREQVEFLKMLRGGKQQ
                     DEDIELPKKWHHGGPCIPGIRSLFVTVEGDLYPCEKVCENVELARMGNINSGIDIQKAS
                     QILNIEDITSGQCKDCWAYRYCDFCIRYAEKEKEELKTCLLRNCADMRKKIEHVFKDYC
                     VLRELGYDFETDSLRKGTENGRK"
     aSDomain        10007..10348
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I2A62_RS12855_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="1.10E-16"
                     /identifier="RREFam021.1"
                     /label="I2A62_RS12855"
                     /locus_tag="I2A62_RS12855"
                     /protein_end="116"
                     /protein_start="2"
                     /score="52.0"
                     /tool="antismash"
                     /translation="EVNKEPFIHLFSCSTGYYLYDVNTDSILKVTPDTYQRLEKRENIE
                     ENEQIRKLKKYGYLKTSHVQISEHPVTKLLPSLYENRIGNLTLQVTQQCNLRCDYCVYS
                     GKYYTRTHSN"
     gene            11433..12128
                     /locus_tag="I2A62_RS12860"
     CDS             11433..12128
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2A62_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_195243575.1"
                     /transl_table=11
                     /translation="MEENKKELFDIDTSVMYILGISEALFDFQLLVQIKACFERKQYSV
                     AIVTDMEMEEEKEDIYSVYDYFSPELSSENLIKANHYIKEIEMNKEYDLFLVGMKKGSV
                     SFGREIPEDLGLSVYGISRILHPDCVLLQVFWGDYQETDLHNMGKETEQIIGEEIDFFC
                     IQNNTVDMYSSLNQHKIISSEIENTVVESTIDGLENSYIFSLNSEKEIERLTEAATEKL
                     HSYAEIERM"
     gene            12135..12395
                     /locus_tag="I2A62_RS12865"
     CDS             12135..12395
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2A62_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_048621013.1"
                     /transl_table=11
                     /translation="MKEEISKKLNQILLKRTGIDFQKQEELQTEDFFGGKIKIPARELV
                     LICFDIENEFSIQIPERELLAGSVKNYVRMKHMVENLLRFL"
     gene            12435..12572
                     /locus_tag="I2A62_RS12870"
     CDS             12435..12572
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2A62_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_155200474.1"
                     /transl_table=11
                     /translation="MQKRLGKKVYRKMPTMQVLAGCACISLCNASGSSMSKMLSIMIAP
                     "
     gene            12643..14316
                     /locus_tag="I2A62_RS12875"
     CDS             12643..14316
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="I2A62_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_270522946.1"
                     /transl_table=11
                     /translation="MDALKYDLKQVIFICKRQVLLLFVCIIIEGCMTYAQPLLLTKITD
                     QGILGKNLTALLSSVLFFVAAKVSVAGMGVLRSYEFVKIHNQMFGRLNEKAFAKLYRIP
                     ISMYKEKNGMQILQALQTDIQSLSSIFDEIAALSVGAVFQVIAGAVGLSVISPQMTILL
                     FAMIVAKFIIVVFFSQRKKEVVKENLLMNNQFMAWLEEQISGIREMKLWNLYTFQNNEL
                     KKLQKKLLQSYQKSAMWDQKYSFCEVSVDTLIMGFLYLLGGYLVIMGKTTAGSLLAFIT
                     YCSNITGSITLLIDVRYYFARIKPSAERFYEFLNGKEEKAIFSKKVCYNENDKELIPVI
                     EFCDVTFSYHGQKPVLDGISFQIYQGEKVAIIGNNGVGKSTLFDLITGLYQPDQGIIKI
                     KGRDIRELGLETIRGKIAVVSQNPFFYNTSVIDNIDLGRRNNMEDVVQVCRLSGADSFI
                     SQMEEGYETMLGNRGLKLSGGERQKIAVSRALLKKAEIVLLDEATTGYDVDSRKHTMES
                     LFSKQTLVKVTHQEEELRGMDSIYRLHRGKLERIRGGEGK"
     gene            14313..16937
                     /locus_tag="I2A62_RS12880"
     CDS             14313..16937
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="I2A62_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_195243577.1"
                     /transl_table=11
                     /translation="MKRKRALDRFTAIRLIAGIAALLTFCLVKFYIDGEFRTWMEVLER
                     LTKGAGITPEYILFFIPFGFVLLYLIRELLLLAGKWWRWFSWLPALGSITFAGVLAFIT
                     YSADILLYAKIPLYYLAMFTVEFISIKYLEQREDLNERYEEIKAREKKDKEHRKKANHF
                     PGKYPPEFYEVIRQNFRYHWKEQIVFLISGILLAAICYIVFAIYFMTDRIYGGKGKTSF
                     MFGQGIHGIFQSLALILGVLSVLMMVLMISWYIKEQKKEYRLMVILGIRKNTAYRIFLV
                     EFSINVLAAAVIGLPIGMIGAAVLRRGFARSFQGHIELPSVVSVSQVLIGFAAYVMLMI
                     LALGFNQENFISLGNSTELNEERKKERKPERRLALWIVSGIGLYVLAIKWITIRGWTEM
                     KFIYCLPALGIFFLLSGGMALWLKKRKNGAGYYKHLFRWNPFYYRFWKNVMVLFYLSVV
                     QFLLLALFSTPFITSNMRQDIPAMYPYDIVCTAYETDLSELEQIAADADATVYQYPMVR
                     MTSLYGSDTVPNWNGSTRPVQWPQGQHIAISESTYNQMRKNAGQKPRKLGLKGKEMHAV
                     YQQDLSVKANVLDWDTTRFSVHLRFGQPLEYYDTAGYWNVFPEREIVSEERNSLIGAFQ
                     QGKQENLIVLSDAYFEEVWNQISTQNRENWAKRETISKAEWKFYSAVHEGNLTEGPTML
                     YCMNVPDGKSAEVAENLEYLKEKHSLDRVWDRSIQPFYERTQMIRNTESEILLARTANG
                     FILLVLVIMAAFQYFLYVKQEEDTWKWEDTFLEKIGMRRKERAKKIGFQLRFFMLLPMI
                     QAVIGGIFFIGITLKARLFTVSEVLRYGRFMGIMYAIYILFWLFIYSMMQRYVLKRLQK
                     ENS"
     gene            complement(17061..17246)
                     /locus_tag="I2A62_RS12885"
     CDS             complement(17061..17246)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009244104.1"
                     /locus_tag="I2A62_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_024733664.1"
                     /transl_table=11
                     /translation="MEKNTAEKGKAKKQVPLRLSQSLYNEIAQWAEDDFRSMNGQIEYL
                     LTECVKYRKKNSKNKQ"
     gene            complement(17272..18261)
                     /locus_tag="I2A62_RS12890"
     CDS             complement(17272..18261)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004841949.1"
                     /locus_tag="I2A62_RS12890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SPFH domain-containing protein"
                     /protein_id="WP_024733663.1"
                     /transl_table=11
                     /translation="METKQSLVHEERIINAKNGFLMLFVSTLLLAASIAMCILGPVLSG
                     MDRISGGLCGFLIALGLVLFIVSIILYCGLKILNPNEALVFALFGKYYGTLKKPGYFWI
                     NPFCSPINPIGSKNSFTMGANGHTSVTTGTKKISLKTMTLDNGKQKVNDELGNPVEIGA
                     IVIWKVVNPTQAVINVENYKNYLSIQCDAIIRNTARIYPYDTSEQGDEKSLRGSSQEIA
                     DIMQLELQEKVADAGIQIIDIRITHLAYAPEIASAMLQRQQAAAIIDARQKIVEGAVGM
                     VQMALDKLNENEIVELDEERKAAMVSNLLVVLCGNKDAQPIVNSGTIY"
     misc_feature    complement(18409..18422)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.49"
                     /tool="antismash"
     gene            18472..18867
                     /locus_tag="I2A62_RS12895"
     CDS             18472..18867
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020967.4"
                     /locus_tag="I2A62_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2007 domain-containing protein"
                     /protein_id="WP_207734861.1"
                     /transl_table=11
                     /translation="MRAVRQESVEAMRPVSIYTAGDRIEAEMLLEALQRNDIQGFREAR
                     GSGGVMDVYTGNSIYGEKIFVDERDAQEAKEIIDSILAQTELEVEPEDEITDQTVKSPR
                     WLRSSMGVLLALLLAFLIGGTVLSIFF"
     gene            19036..20685
                     /locus_tag="I2A62_RS12900"
     CDS             19036..20685
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012475.4"
                     /locus_tag="I2A62_RS12900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GH32 C-terminal domain-containing protein"
                     /protein_id="WP_053769458.1"
                     /transl_table=11
                     /translation="MRFNTQKYRQLELFIKTEPGETGRLYMVSGSARKMFQISQYRKWL
                     KITVNPGTTYEVSAENCEISYAYLSGCEQMLERGICMIQDGRFYDRSQWGEWYDTPIRN
                     QYHLSPPKGWMNDPNGFCVYHGYYHLFYQFHPFSEEWDNMYWGHAVSQDLIHWVHLPVC
                     MEPQQEILNYPELVGGAFSGTALVDEEQKLRLFFTRHIGKRRDRTAFREYQVMTESRDG
                     LNWERESRIIEGPEGRDFRDPKVFYENGEYKMLIGIRGEEHPAISLYKSYNLAQWTYCG
                     EIFEEQKEEENFPLECPDLFRLDNQWVLTAGYCGHVDGHGRKNSIYYHIGEWYQDQFHE
                     EARGLYDFGADFYAVQTIDTETGRVAVGWISDVAKEHVKSPNGACGSMSIPRVLHIKDG
                     KLYQNPVQGIYRLIRYPVYEGCGEDVEVTGIEGNTYYVKLEMEKPSDFRMTLYKWKDRK
                     LYLEQKDGQCRFRTVGEGAKNILYPAEISDVTTVEVFVDRNVCEVFLNDGQAAGAKKFY
                     QQSETGNFEFHVQEKGTVKSLVVEKMEGIWKQ"
     gene            20682..21242
                     /locus_tag="I2A62_RS12905"
     CDS             20682..21242
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012905.4"
                     /locus_tag="I2A62_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD hydrolase-like protein"
                     /protein_id="WP_330614946.1"
                     /sec_met_domain="HAD_2 (E-value: 2.7e-30, bitscore: 97.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKIRAVLFDMDGVLIDTEKYLTRFWRQAAAEAGLLLSLEECYAF
                     RSFAGKYAAPWFAEKYGEQYDYWTIRERRKELMQEHIRVHGIEKKDGVEEVLQVLSQEG
                     YQTAVVTATDETRARQYLRDIGILELFDAVICANMVERGKPFPDVYLYACEKIQNRKNR
                     RTVWRWRILQTESGRRMAPDVMW"
     gene            21179..21370
                     /locus_tag="I2A62_RS15615"
     CDS             21179..21370
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01509.1"
                     /locus_tag="I2A62_RS15615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_330614947.1"
                     /transl_table=11
                     /translation="MAVEDSPNGIRAAYGAGCHVVMVPDLTQPDEESQNRIERKAASIR
                     DIPGVVREISRGKLQYGR"
ORIGIN
        1 ccggcatgga ttcaggtttg ctgtttccat cggtataagt aagcataccc gtttcacggt
       61 tccagacgaa atcatattcg ctggcttttc ctgccgcaat aatttccaga ccaagaaggt
      121 ttgcccaaga gcatatatca agaagattcc ttggctgatc tccgtttaca agagaataaa
      181 cggctccatt ttcagcagca gtctgattta gcattggccc acatacactg tcagtttctt
      241 tagagaccat atacacatta attcctcttt ttaatgcagt gagagccgca tctgcgctga
      301 ctgtggtgtt tccggtacat tctaccagcg ctgtaattcc acattccggc aacagacggt
      361 agtcgcttac gattaaaaca gcatcctcat ctgcgctgtg aattgcttct tttgtttcac
      421 aatatactat ttggttttcc ttataaccga tttcttttag taccgcctga cattcatccg
      481 gatgtctgga acagatgacc cggagatcca tcagtttgac ttttggaatc tgtgcaagaa
      541 gagtataacc ataccctcta gttgctccaa tgattccgac ttttgatttt tttccggagc
      601 tgtcgttaag caaattcgta taatccatat ctacattctc ctttttgaaa atttgcagaa
      661 tctttcgaca ttaaatctgt ccggtaggac gctgcatcaa tcttttaacc atatatatag
      721 caagtgatgt gccaaatcca ataaactgat tgtaacagtt tagtcacgca gcggctaatc
      781 cgagctgtga tggctgaact gttacaactg atttcagatt ctaatctatg tatgcggcat
      841 gtatatgtaa atagggatat tttggaactt atggatgatg gtgatgttat gaaatgttgc
      901 aaaacgttgc aacgacgttg atgcagtcaa ggggctcttg ggcttcagaa tgtgaggata
      961 tcatttttaa tgatacattt gttcgggaga agaagtttca gtctcttgac agagaatgag
     1021 agcctgttat aattcgaatt aaaagtataa aaaactataa ggtgatacga aaaggagaaa
     1081 gaaaatgtta gatgcgaaag ttgcagaatt attaaacaca cagatcaata aggagtttta
     1141 ttccgcctat ttatatttgg attttgcgaa ttattatacg gaagaggggc ttgacggttt
     1201 tgccaactgg tacaatatcc aggcgcagga ggagcgggat catgctatgc tcattctgaa
     1261 atacttacaa aataacggct gtaaggtgac atgggaggcg attgataaac cggataagag
     1321 gtatcattct tttgcggatc cgctgcatgc gggctatgag cacgaaaagt atgtgacaag
     1381 tttaattcac aatatctatg atgcggcaaa tcaggtgaag gattttcgta ccatgcagtt
     1441 tctggactgg tttgtaaaag agcaggggga agaagagacg aatgcggaaa atatgattaa
     1501 gaaatacgag ctgttcggtt cagatccgag agcgctttat atgctggatg gagaacttgg
     1561 tgcacgtgtt tatacagcac cgtctcttgt attataagat taagaaaaaa gaagaaagtc
     1621 ggaggcggca gaacgggggg agaaacatcc tatgtgcagc gtgttttatg ttggcgagaa
     1681 tatgatacag aagatgaaac atctgaccca ggagattgat aaggaagcag agaaggtgaa
     1741 gctggagcgg gatattcatc ccacagatcg ggcgttgatt ttgcggtggg gcgatcacaa
     1801 gattagactg tcaggaatga aatggggata tccggtgata catggatcag gggtactgat
     1861 caatgcgaga gctgagtccg tgatggaaaa aaggacgttt gcggagggaa tccgatacca
     1921 tagggcggtc attcctgcga gtcattttta cgaatggaat tcgaaaaagg agaaatatac
     1981 atttcaaagg aaagacagga gtgtcctcta tttagcaggt ttttttgatc ttattgataa
     2041 cgaagaatgt ttcatcatat tgacgacaga ggccaatgca tcgatgaggg ctgtccatgg
     2101 ccggatgccg ctgattctgc aagaagatca gattgaggac tggctccggg atggaaaggt
     2161 gacggaggag attctgcgtc aggttccgat ggagctggtt cgaacagcga aatacgaaca
     2221 aatgacgctc tttccgatgt aaatagaatg gaaccgatgg agggggaaac aaaatgaaaa
     2281 tcgaaatgca cgttcacaca agtgagggaa gttcctgtgc gaaggcagag gcccaagaga
     2341 ttgtcaaagc atacggcgaa gccggatatg atgcgattgt cattacaaat cactttgatc
     2401 ctcttttgct tcaggagttt ggggagacgg atgagcagaa gatcgaacgg tatctgcttg
     2461 gttaccgtaa ggcgagggaa gccggaaaac gatatggagt taaagtgatg tttggcgttg
     2521 agattcggct ggaaccaggg gtagaagatt ttctgattta tggaattgat gaggagtttt
     2581 tattccaaaa tcccaatctt tgctttttga gccagagtga agtgtttaac cgatgtcatg
     2641 cctacggagc agtcttttat caggcgcatc cgtttcggga gccgtgtgtt ccacagcgtc
     2701 cggaatatct cgacggtgtg gagtataacc agcgcccgaa cagtgggaat cacaatgaaa
     2761 aattggatgt gtggcggaag gactatccgg agttaaggct tatatctgga agcgactgtc
     2821 atgacctaga tcaagtagga tatggaggca ttgagataga agagaatgta gacaatatca
     2881 aagagattgt cgcaatcatg aaaaagggaa actatcgttt gattacaaca ccagtttaat
     2941 aacagaaaaa agagactttt catctctttt tctaccatta taataccaca aaatggccga
     3001 aaaatcaagt ctggcaatgc catgcgcccg gtgctatact tggctctcaa acgataaagg
     3061 aggcatgtgc atggaacaga actggatgca gttactggat cagcaaaatc agctatccag
     3121 agtgatggag accaaccgta cggcgcagac ctatggtctt atactaagtg agcaagatgc
     3181 taagttgctt ttgaaggaga ggggcagagc gcttaagaag gagaagagag tggaattcgg
     3241 cgagggaatt ctgcctaaga tgatctatga attctgcgat tgcccgtatc tgaatcagga
     3301 gcattatgtg gagaccctag tacgattgca ggatatcttt tatctctata agaatgagat
     3361 gctggatgag attacggatg atgagcttct gcattttatg agagagcaat atgaaactgt
     3421 ctgttttggg gatctggact atctggaggg gacttgtctg gatattttcg cacaggcgat
     3481 ccgggccgga tacaggggat accgggtgac ggatggaaga agtgagtatg gacagtttga
     3541 tgaagtgaag cgttgggatt atgagctgta tctggaggcg cttcaggatc tttgctggag
     3601 gtgatggctg tgtggtatga gatggaagag cttgtgccaa tcgttggcag actggcacgg
     3661 aagtatacgt caggagacag tacctctatt tcctatgaaa aggcagagca gttgatggga
     3721 gcagttctgt actgtatccg ggaagccgga gcacagagaa aatgggctgt tacggacagg
     3781 gagaatctga cggcagagac ggcgtatctt acgggggcag cgtgcgtgga gaaaaagacg
     3841 aaaagagcat taagactata tcaccagata ttaaagaatt ttgattccta tgagcagcac
     3901 tgtctgaatg aaacaatcac aaaaggaatg ccagaatatt tccggtggta cgatcccatt
     3961 ttcgcaccac aggagacgct tctgacactg gactatccag tgctggaaga tttgaaggat
     4021 tatacaggaa ttgactgtgt agagcgatgg ctttcccgtg tgaaacagga gcagcagttt
     4081 cttcattgct ttccaagggc cgatttgatc tggatgctgg aggaatatga tgaggactac
     4141 cgggatggaa tggataatct gtgcgagatg gttttaagcg tctgtgtgaa acaagttctt
     4201 gccgggaaat ccttggcaaa ccgggtattt ggccgggaag aggaaaatcg gattcgggaa
     4261 acgcttgagc agggaggagc tcggcttctg gatgaaaaga tttatccggt tttgcgaaag
     4321 cttgtgtcga aagcagggag ggatgcagat gctttgtggt tttatctgtt tccggccatc
     4381 gattctgctt ttgtacggat acaatatacc gctcgtcata gaggacagga ggcggatgat
     4441 cgggtgatag aaatagagtt acagagggag gttacatatg agacagagac aacaactgcc
     4501 ggattacaga gacagtctgc cgaacctggc gcagtcgatt ttgcgtgaat ttggtattac
     4561 agaagttgga agggagagtc tgaaaagtct ggatccatat ttgggaaaag gttatcaaaa
     4621 tatcgttgtc cttttactgg atgggatggg gtcaaaagtt atggagagaa gtctggaggg
     4681 ggatggattc tttctcagac gtaaaaaagc agactatcat tcggtatttc caccgactac
     4741 ggttgcggcc accacatcga tccggagtgg gcttcagccg tgtgagcaca gttggcttgg
     4801 atgggactgc tactttccgc agatcaataa gaatgtgacc gtctttacaa atacagagac
     4861 cggaacaagc actccggcgg cagactacca tgtagcacaa aaatactgcg gatatgagac
     4921 cgtggtagag aaaatcaacc gacacggagg gcaggcttat gaagtcatgc cgtttgagga
     4981 gccatttcct cagacaatgg aggcgatctg tgagagaatc gaggagcttt gccggaaacc
     5041 gggaaagaaa tacatttatg catattggaa tgagccagac aagacaatgc atgagaccgg
     5101 atgctacagt gaagagacga aacgagttgt ccgtggactg gaagaacagg tggagacatt
     5161 atgcaggaag ctcaatgatg cgcttgtgat cgtgacggcg gatcatgggc tggtggatac
     5221 aaaaaatgtt tcccttacgg actatccaaa gatctgtgag tgtctgaagt ggcttccgtc
     5281 catcgaacca cgggctttga atctgtttgt aaaagaagaa aagaaagatc agtttgagca
     5341 ggaatttgaa aaagcttttg gaggacagtt tctgctgatg acaaaagatc aggttctgga
     5401 gagtcaaatc ttcggggatg gaacagaaca tccgaatttc cggggaatga ttggagacta
     5461 cctggcaatc ggaataggtg atgtgacgat tttttctgac agagaagagg cggaaagcat
     5521 gaaaggagtc catgcgggac ttctggaaac ggagatgcag attccgctta ttgtggaaga
     5581 acgggcgtag catgaagatg gtggatgtac ttatgccaca tctgccgcga gggggcgcct
     5641 agatgaaaat aaaagggatg taccacggaa aggatctgtg gacatccctt ttcgtatctg
     5701 ataaatctca gatcatacat gttagacgac ttttggcagg ggggatcact ccgctttcat
     5761 tggcagcagg aaggtaaata tgctcccttc tcctggcgaa ctttttaccg agatagttcc
     5821 gccgtgagct tcgacaatcc acttgaccat ggagagcccc agaccggagt ggcccgatgc
     5881 acttcgtgag gaatccaccc gatagaagcg ctcccagatg tgaggcagat cctccgccgc
     5941 aatgccaatg ccgtcgtcct ctacctggcc tacgaagaaa ccgctctgtt catagcagga
     6001 gacgaggata tggccgccgg cctttccata agaaattgcg ttagatatga ggttgacaag
     6061 catccggata taaaaggtct catctacctt tacgaaaaga tccggttcga tctgtgtggt
     6121 gatggcaatc ttcttttcct cagacagcat agcctgttct tcacagacca tctcggtgag
     6181 ttcactgaga ttcaaaagct ccggctgtaa ttgctgtctt ccttggtctg cccgcgaaag
     6241 caggagaagc tgagagatca tctgcgccat gttctgcgct tttttctgga tgagtccgat
     6301 cgaaacacgc tgttcggccg gtagggacgc atcagataat attgcgtcac actgggcaag
     6361 aatgaccgtc accggggtgc ggagttcgtg ggaaacgtcg gaggtaaact gttgttctcg
     6421 ctgaaaggcg ctctcgatct tggtaagaag ctgatcaaaa gtatccgcaa gctggtaaat
     6481 ctcatccttt ccttttccaa gttctacccg gcgggacaaa tcctggtcac cttgaatctg
     6541 acgcacggtt tcagtgatcc ggcggacagg ccgaagggtc cttctcgtaa acagatagcc
     6601 gatcacggcc gtcagtacaa ccagaagggg aagaacaatg acagcgaacc tcagagtaat
     6661 ccgaaaactg gattccgcat ccgtgacaga ggaaatgccc cggacaaata caagaccgta
     6721 gccgttcagc cgataggaaa gatcatagat ataccactgt ttttcggcgt cggacagggt
     6781 ttggatttgc ccatcggaaa aatcaggatg cagggaaaat ccataaggta tccggccaaa
     6841 tagaaagtcg ccattttctg tgtagagtga gaggtatacc cctccatcca gattgtagaa
     6901 atcagaatcc agatcaaaag agccgtcttc ccactcgata tctttcaggc tttcgtgaag
     6961 ctgcttcttt aacgtattct gagtggaggc aagaatctct ttattgctca gagagaaaag
     7021 aatcgcaaga gccgcacacg tcaaaagcgt cataaaaaag gaatataata acgtaagttt
     7081 taattttaag gaaagtcgtt tcatattgcc accttcagaa catagccggc gccccgcacc
     7141 gtatgaatta gctttggctc aaatccatca tcgatctttc gccggagata gcggatgtag
     7201 acatcgatga cattggagcc tccagtaaaa tcataattcc agatgtgctg ttccagctta
     7261 tccctggaaa gcacgattcc ttcattttgc atcaggtagc gaagcaagga gaattccttt
     7321 cctgagagat ggatttccgt gtcgccacgg aacacctgat gggtatcaag aaggagtttc
     7381 agatttgcgg tctgtagaca attagaagga gcttcggcag gtttccttaa aaggactcgg
     7441 attcttgcca gaagttcctc aaaggcaaag ggcttcacga gataatcgtt ggccccggcg
     7501 tccagtccgg ccacacgatc ctcaatacta tcctttgcgg ttaagaggag tacgggaacc
     7561 gcacaacccc ggcggcgaat ggactttagg acgctcagac cgtccagcac aggcatcata
     7621 atatccagaa caagtgcgtc atattccgcg ccggccatat actccaacac ctcctgaccg
     7681 tttttacagg aatccacact gtagtgttcg gcctttaaac gcgcagtcaa aatccggtta
     7741 agatcttttt catcttctgc aattaagata cgcaaataga tcaccatcct tatcgttact
     7801 atttatcagt atgtgactgt tcacggaagc gccattccta aaacatacta catgtttatc
     7861 gtggctgttg ccactgattt attcagggaa tggtactttc tttgtctgca tgaaggccag
     7921 atgtcccttg tactggcata acatccggca ttaggcatac gggtgaactg taacatcagt
     7981 ataaaacata ataaaaaaga aagaaagaaa aacttgacac taccagggaa gcgaagtatg
     8041 ataaggaaga aatcggtagg tgaggttacc acagggattt gggccaccta agattgctac
     8101 cgctaaattg tggagacaca atgcgctggt taacaggtca tgtcgccgat aaggcataac
     8161 ctaatgcaat tattatgccc tgtgatacta aagcttggac gtaggaaagt ttgaggtaga
     8221 tatgatctcc ggttttgtgc cggagatttt tttcttctat aggataggcg tctgaagaac
     8281 gatcctatag aaaaaaaggc cctccgggta gaaccgagga aaggaaaggc aggtgaggcg
     8341 caatggatgc tggaggcagt tatgactcgt tttgttacat gaaaacatgg ataagagaaa
     8401 gtagggattg ctatgaacag acagatttta acagaccttt taaggaagag agacttcaag
     8461 gcagtcagaa gtattctgga ggtcatgtac accgtagata ttgcggctct ccttgccgag
     8521 ttggacgata aagagatgat tctggcgttt cgcctgattg aaaaggccaa ggcggcagaa
     8581 gtttttgcag agatgagtag ctccatgcag gcctatctgg tggaaatgtt tacggaaaaa
     8641 gaattaaaag agcttttgga tgagctctat atggacgaca cagtggattt gctggaggaa
     8701 ctaccggcaa acctggtgac acggattctg gagcaggttg acagggagaa aagggcgcag
     8761 atcaacacga ttctcaacta tccggaggac agcgccggaa gcataatgac gacagagtat
     8821 gtggatctgc gtcgtaccac aacagttcgg gaagcaatgg aacacatcaa acagaccggg
     8881 attcataagg aaacgatcta cacctgttat gtcctggaaa acaggaaact gatcgggatt
     8941 gtctcagcca aggatctgat gacgatggat gatgacctga tgatggatga gctgatggag
     9001 aaggagatta tttccgtgac gactcataca gatcaggagg aggcggtgcg cctgttgtca
     9061 cgatacaatc ttttgtccct gccggtgctg gatcagcagg gatatatggt tggaatcgtg
     9121 acgatcgatg atgcgatgga cgtcctggta gatgaaacca cagaagatat ggagattatg
     9181 aacgcattaa gtccgagcga gcagccatat tttgagacag gtgtgtttcg gcatgcaaaa
     9241 aatcgaattg tatggttatt atttttgatg ttatccgcca cactcaccca gacgattatt
     9301 gcacactatg aggctgcgtt taccgcggtt ccgctccttg tttccttcat tccgatgctg
     9361 acggatacag gcggaaactg cggttcccag agttctacgc tgattatccg gggactggcg
     9421 ctggatgaaa tccattttgg ggatatcttc agggttgttt tcaaggaatt ccgggtggcg
     9481 attctggtgg gcgccgcact ggctgttgtc aatggcgtat acatggtgat tcgttatcgg
     9541 gacccaatgt tggcgcttct tgtatccatc tccctggtag ccactatttt gatcgccaaa
     9601 atgatcggat gcgtgcttcc gttgtttgcc aagaagcttc acatggatcc ggctattatg
     9661 gcggcgccgc tgatcacaac gattgtggac gtctgctcca tcatggtgta ctttcaggtg
     9721 gcgacccatc tgctgggact gatttaagaa aagagaaaat gaatatatga caaataagaa
     9781 ggactgatta tgggtattca gattcagcaa agatttgata tccatgatta gtcctgtttt
     9841 tatgaaagta tgacagaaaa gaggtaaagg tatatagggt aaaactcatg gactcaaaat
     9901 aaaaactgat ggacaaagtg ttgaaaagaa actgggaaaa tagtagtttg tttgtataaa
     9961 gtgatgaaaa ataagtgtga gtgcaaagaa aggaaagaat atgaaagaag ttaataaaga
    10021 accatttata catttatttt cttgttctac cggatattat ttgtatgatg tcaatacaga
    10081 ttctattttg aaggtcactc cggatactta tcaaaggtta gagaagcgag agaatattga
    10141 ggaaaatgag caaattcgca aattaaagaa atatgggtac ttaaaaactt cacatgtcca
    10201 aatatcagag cacccggtca cgaaactttt gccatcgctg tacgaaaata gaatcgggaa
    10261 tctcacttta caggtaacac aacagtgcaa tttacgatgt gattactgtg tgtattctgg
    10321 caaatattat accagaaccc attcaaataa gagaatgagt tttgaaatgg caaaaaaggg
    10381 attggatttt ctgctgtcgc attcttctgc ctgcgaagaa cttcgtgtgg gattttatgg
    10441 cggagaacca ttactggaat ttgagttaat caagagatgt gtagaataca tggaaacaca
    10501 gaccaaagat aaagcagtcc attatcagat tacaacaaat ggaaccttat tgaaaggcga
    10561 aatacttact tatctgatag agaaaaagtt tgaaatcacg attagttttg acggacctaa
    10621 agagatccac gacagataca gaaaatttgc tggaagtgac aaaggcagct atgacaccgt
    10681 gatgcaaaat gcacgttata tcaaagagca ttatcataac ttctttattt ctaatgttac
    10741 ctttaataca gtcatcagtc cggaagaaag ctatagctgc attggaaatt attttaaagg
    10801 ggaagaactg tttcaggatg cggtttttac atccggtcta gtaaaagatg aggggaaaaa
    10861 agagaaaaac acagtatcag accgtttttc agaagaatat caatacgaat attttaaact
    10921 tttgatgagt aagcttggaa aaataagaaa agagaatact tcagttctcg gaagggagca
    10981 ggtagaattc ttgaaaatgc taagaggagg gaaacagcag gacgaggata tcgagcttcc
    11041 aaaaaaatgg catcatggtg gcccatgtat accagggatc agaagtctat ttgtgactgt
    11101 cgagggagac ctatatcctt gtgaaaaggt atgtgaaaat gtggaacttg ccagaatggg
    11161 taatatcaac tctgggattg atattcaaaa agcgtcccag attctgaaca tcgaggacat
    11221 aacatccggt cagtgtaagg actgctgggc atatcggtat tgtgattttt gcatccgata
    11281 tgcggaaaaa gaaaaagaag aattaaaaac atgtctatta agaaattgtg cagatatgag
    11341 aaaaaagata gaacatgttt ttaaagatta ctgcgtgttg agagaactgg gatatgattt
    11401 tgaaacagac tctctaagga agggaacaga aaatggaaga aaataaaaag gaactatttg
    11461 acatagatac ttcggtgatg tatattcttg gaatttcgga ggcacttttc gattttcagt
    11521 tattagtaca aataaaagcg tgctttgaaa gaaaacaata tagcgtggcg attgttacgg
    11581 atatggaaat ggaagaggag aaggaagata tctatagtgt gtatgactat tttagcccgg
    11641 aattgtccag tgaaaatctg ataaaggcaa atcattatat taaggaaata gagatgaata
    11701 aggagtatga tttgttcttg gtcggcatga aaaagggttc cgtttcattc ggaagagaaa
    11761 ttccggaaga tttaggactt tctgtttacg gaatttcaag aatccttcat ccggactgtg
    11821 ttttattaca ggttttctgg ggagattatc aggagacaga tttacataat atggggaaag
    11881 aaacagagca aatcataggg gaagaaattg actttttctg tattcaaaac aatacagttg
    11941 atatgtattc ctctcttaat caacacaaaa tcatttcatc tgagatagaa aacacagtgg
    12001 tggaatcgac aatcgacggt ttggaaaata gctatatttt ttctttaaac agtgagaagg
    12061 aaatagaacg attaacagaa gcagcgaccg agaagttaca tagttatgca gaaatagaga
    12121 gaatgtgaat aggaatgaaa gaagaaatca gtaaaaagtt gaaccagatt cttttaaaga
    12181 gaacaggaat cgattttcag aagcaggaag agttacagac agaagatttc tttggaggaa
    12241 aaataaaaat tccagccaga gagcttgttt tgatctgctt tgacatcgaa aacgaattct
    12301 caatccagat tccggaacgt gaattgcttg cgggaagcgt gaaaaattat gtgagaatga
    12361 aacatatggt ggaaaacttg ttaagatttt tatagattaa cagttgaaat cacaggaaga
    12421 aggaggtgaa atatatgcag aaaagattag gcaaaaaagt ataccgaaaa atgcctacga
    12481 tgcaggtttt agcagggtgt gcttgtatat cactttgcaa tgcttctgga agcagtatgt
    12541 caaagatgct ttctattatg atcgcaccgt aaggaaaatg gagaggagat tacagcaacg
    12601 taatctcctc ttcgtcataa gataataaag ggatatcgga gaatggatgc tttaaagtat
    12661 gatttgaaac aagtaatatt catatgcaaa aggcaagtac ttttactttt tgtatgtatt
    12721 ataatagaag gatgtatgac ctatgcccaa ccgttgctgc tgacaaagat tactgaccaa
    12781 gggattcttg ggaaaaactt aacagcactt ctttcatcgg tactattttt tgtcgccgcg
    12841 aaagtgagtg tggcgggaat gggagttttg cgatcctatg aattcgtgaa aatacataat
    12901 cagatgtttg gcagattaaa tgaaaaggca tttgctaaat tatacagaat tccaatcagc
    12961 atgtataaag agaaaaatgg aatgcagatt cttcaggcct tgcagacaga catccagtct
    13021 ctttcttcca tttttgatga aatagcagca ttgtcagtag gagcggtttt tcaggtgatt
    13081 gcaggtgcag tcgggctgtc tgtaattagt cctcaaatga caattttgtt atttgcgatg
    13141 attgtggcaa aatttattat cgttgttttt ttctcacaaa gaaagaaaga agttgttaaa
    13201 gaaaatttat tgatgaataa tcaatttatg gcttggttgg aagaacagat tagtgggatt
    13261 cgggagatga aactttggaa tctttatacg tttcagaata acgaattgaa aaaattacag
    13321 aagaagctgc tgcagtctta tcaaaaaagc gccatgtggg atcagaagta ttctttttgt
    13381 gaagtgagtg tagatacact gattatggga tttttgtatc ttctgggagg gtatctggta
    13441 atcatgggaa aaacgaccgc aggcagtcta ttagcgttta ttacttactg tagtaatata
    13501 acaggatcga tcacgttgct gatcgatgta agatactatt ttgccagaat caaaccttca
    13561 gcagagcggt tttatgaatt tttaaatggg aaagaggaaa aggcaatatt ttcaaaaaag
    13621 gtgtgctata atgaaaatga taaggagctt atccccgtga ttgagttttg tgatgtgacg
    13681 ttttcgtatc atgggcagaa gcctgtttta gatgggatat ctttccagat ctatcaaggg
    13741 gagaaggttg ccattatcgg caataatgga gttggaaaat caacactttt tgatttgatt
    13801 acgggactat atcaaccgga ccaaggaatc attaaaataa aaggaagaga tattcgtgaa
    13861 cttggtttgg aaacgatacg aggaaagatt gctgtagtca gccaaaatcc gtttttttat
    13921 aatacgtctg ttattgataa tatcgatctt ggaaggcgaa ataacatgga ggacgtggta
    13981 caagtttgtc gtttgagcgg agcggattcc tttatttctc agatggagga aggatatgaa
    14041 acgatgcttg gtaatcgcgg attgaaactt tcgggcggcg agagacaaaa gatagcggtg
    14101 tcgagggcgc tgttaaagaa agctgaaata gttcttctgg atgaagcgac gacaggatat
    14161 gatgtggatt ccagaaaaca taccatggaa agtttgtttt caaaacagac acttgttaaa
    14221 gtcacgcacc aggaggaaga gctaagaggg atggattcca tctaccgctt acatcgaggg
    14281 aaactggaac gaatacgagg aggagagggg aaatgaaaag aaaaagagca cttgacaggt
    14341 ttactgcgat ccgactgatt gccggaatag cagcactttt gacgttctgt ctggtaaaat
    14401 tctatattga tggagaattt cggacatgga tggaagtact ggaaagactg accaagggag
    14461 cagggattac accagaatat attctgtttt ttatcccttt cggattcgtg ctgctctatc
    14521 ttattcggga acttttgctt ctggcaggga agtggtggcg atggttttcc tggcttccgg
    14581 cgctgggatc tattacgttt gcaggagttt tggcatttat aacgtattcg gccgatatac
    14641 tcctttatgc gaagattccg ttatattatc ttgccatgtt taccgtggag tttataagta
    14701 ttaaatacct ggaacagaga gaagacctga acgagcggta tgaggagatc aaggcgcgag
    14761 agaaaaaaga taaggaacat cggaaaaagg ccaaccattt tccaggcaaa tatccgccgg
    14821 aattttatga agtgattcgc cagaatttcc gttatcactg gaaggagcag atcgtttttc
    14881 ttatttccgg aattctgctc gccgcaatct gctatattgt ttttgccata tattttatga
    14941 cagatcggat ttacggaggt aaagggaaga cgagtttcat gttcggtcag ggaatccatg
    15001 ggatttttca gagtcttgcc ctcattctgg gcgtgttaag tgttctgatg atggtgctga
    15061 tgatttcctg gtacattaag gagcaaaaaa aagaataccg gctgatggtg attctcggaa
    15121 tccgaaagaa tactgcatac cgcatctttc tggtagaatt ttcgatcaat gtgctggcgg
    15181 ctgcggtaat cggtcttccg attggaatga ttggggcagc tgtcctgcga agaggatttg
    15241 caaggagctt tcagggacac atagagttac catccgtcgt cagtgtttcc caggttctga
    15301 tcggttttgc agcttatgtg atgttgatga ttctggcgct tggctttaac caggaaaact
    15361 ttatttccct tggaaactcc acagaattaa atgaagaacg gaaaaaagag agaaagcctg
    15421 agagacgact ggctctttgg attgtatcgg gaattggttt atatgtcctc gcaatcaaat
    15481 ggattacgat tcgtggctgg acggagatga agtttatcta ttgtctgccg gcgcttggaa
    15541 ttttcttttt gctttccggt gggatggcgc tatggctgaa aaagcggaag aacggggcgg
    15601 gctattacaa acacctgttc cggtggaatc cgttttacta tcggttttgg aagaacgtta
    15661 tggtactgtt ttatctgtcc gttgtccagt ttttgctcct ggcgctgttt tctacaccct
    15721 ttatcacgtc taatatgagg caggatatcc cagctatgta tccgtacgat atcgtgtgta
    15781 cggcatatga gacggatctt tcggaactgg agcagattgc ggcagacgcg gacgccacag
    15841 tttaccagta tccaatggtg cggatgacgt cgctgtatgg aagtgataca gttccaaact
    15901 ggaatggttc tacacgtccg gttcaatggc cacagggaca gcatatcgca atctctgagt
    15961 cgacctacaa tcagatgcgg aaaaacgcgg ggcagaagcc tcggaaactg ggattgaagg
    16021 ggaaagagat gcatgccgtc taccagcagg atctgtcggt caaagcaaat gttctggatt
    16081 gggatacgac caggttcagc gtacatctcc gatttgggca gccgcttgag tattatgata
    16141 cagcgggata ttggaatgta tttcctgaac gggaaattgt aagtgaagag agaaacagtc
    16201 tgatcggagc gtttcagcag gggaaacagg aaaatctgat tgtgctgtcg gatgcatatt
    16261 ttgaagaagt ctggaatcag atcagtacac aaaaccggga gaactgggcc aaaagggaaa
    16321 cgatttcaaa ggcggagtgg aagttttatt cggctgtcca cgaagggaat ctgacagagg
    16381 gacctacgat gctgtactgc atgaatgtac cggacgggaa atcagcagag gtggcagaga
    16441 atctggaata tttaaaggag aaacacagcc tggatcgtgt ctgggaccgt tctatccagc
    16501 cgttttatga gaggacgcag atgatccgga atacggaatc cgaaatcctt ctcgcacgga
    16561 cagccaatgg atttattctt ctggtactgg tgattatggc agcattccag tattttcttt
    16621 atgtaaagca ggaagaagat acatggaaat gggaagatac attcctggaa aagattggta
    16681 tgaggagaaa agaaagggca aagaaaatag gatttcagct tcgtttcttt atgctgctcc
    16741 cgatgatcca ggcagtaatc ggcggaattt tctttattgg aattacttta aaggccaggt
    16801 tgtttacggt gtcagaagtc ctgagatatg gaaggtttat gggtatcatg tatgcaatct
    16861 atatattgtt ttggcttttt atctactcga tgatgcaaag atatgtccta aaacgtctgc
    16921 aaaaggagaa tagttaaaag tagaagaaat gattgtgaca cacagagcaa tcataatttc
    16981 caacagcaaa tcgggcgaaa cccttccgta agagacggcc tatgccgttt ctatcattag
    17041 gggctccgcc cggttcgctg ttactgtttg ttttttgagt tcttttttcg gtatttcaca
    17101 cactcagtta aaagatattc gatctgcccg ttcatggaac ggaaatcatc ttctgcccac
    17161 tgggcaattt cattgtaaag gctttgcgag agcctcaaag ggacttgttt tttggccttt
    17221 cccttttccg ctgtattttt ttccaaaatg tgtcccacct tttttctgga tttagtagat
    17281 ggtaccgcta tttacaatcg gctgtgcatc cttgtttcca cacaacacga caagtagatt
    17341 gctcaccatg gcggctttcc gttcctcatc cagttcgaca atctcgtttt cgtttaattt
    17401 atccaacgcc atctgcacca tgccgacagc gccttccacg atcttctgac gtgcatcgat
    17461 gatagctgcc gcctgctgtc tctgcaacat ggcggatgcg atctccggtg catatgccag
    17521 atgcgtgata cggatgtcaa taatctggat accggcgtca gcaactttct cctgaagttc
    17581 caactgcata atatccgcga tttcctggct actgccacga agtgactttt cgtctccctg
    17641 ctcgcttgta tcatacgggt agatgcgggc tgtgtttcgg atgatagcgt cgcattgaat
    17701 ggagagataa tttttatagt tctctacatt gatgaccgcc tgcgtcggat tgacgacttt
    17761 ccagatgacg atagctccga tttctaccgg atttccaagc tcatcattga ctttctgctt
    17821 accattgtca agcgtcatag tcttgaggga aatctttttc gtgcccgttg tgaccgatgt
    17881 atgaccgttt gctcccatgg tgaaagaatt cttcgagccg atcgggttga tcggggagca
    17941 gaatggattg atccagaagt aaccaggctt tttcagtgtg ccatagtatt taccaaaaag
    18001 ggcaaataca agggcttcgt tcggatttaa gattttcagt ccgcagtaca gaatgatgga
    18061 cacaatgaaa agcacaagac caagagcgat gaggaatccg cagagcccgc ccgaaatccg
    18121 gtccataccg gaaagaaccg gacccaagat gcacatggcg atgctggcag ccagcagcag
    18181 tgtgctgaca aataacataa gaaatccatt tttcgcattg ataatgcgtt cttcgtgaac
    18241 caaagattgt tttgtctcca taactcttcc tccttcagtc ttacatgagt taaagtgata
    18301 ttattttgat atcataatag atctaaagca gaaaattgtc aagagaaaat ctatatattt
    18361 tttcggaagg gaaatagggg taacccttgg aaaaagtaca taaaaggatt ataataatag
    18421 tagaaatctt tgacatacat tccgctgatg taaaggaaaa gaggtgtttg tatgagagca
    18481 gtaagacagg aaagtgtgga ggctatgcgt ccggtcagta tttacaccgc aggggatcgg
    18541 attgaggccg agatgctttt agaggcactt cagagaaacg atattcaggg cttccgggag
    18601 gcaaggggtt ccggaggggt catggatgtc tatacgggga attctattta tggagagaag
    18661 atttttgtag atgaaaggga tgcacaggag gcaaaggaga ttatcgattc gattctggct
    18721 cagacggagc ttgaggtgga gccggaagat gagattaccg atcagactgt gaagagtccg
    18781 aggtggctta ggagcagtat gggagttctg cttgctcttt tacttgcgtt tttgatcgga
    18841 ggaactgtgc tgagtatatt tttctaagat aaagaggcgg tatcgtctcc ggagagattc
    18901 tgtcgtaatg aatcagacaa gagagctgaa tcgttacacg ttcggagggg ataccgcttt
    18961 ttaaatgcgt tgctttgtga tacactgtaa gggtaagagc tgatgacaaa tacgcctgag
    19021 tacaggagga agaacatgag atttaatacg caaaaataca gacaactgga attgtttatt
    19081 aagacagaac ctggggagac aggcagactt tatatggttt ccggaagtgc gcgcaaaatg
    19141 tttcagatca gtcaatacag aaagtggctg aaaattacgg tgaatccggg gacgacctat
    19201 gaggtgtcgg ctgagaactg cgagatttcc tatgcctatt taagcggctg tgagcagatg
    19261 ctggagagag gcatctgcat gatccaggac ggaagatttt atgacaggag tcagtggggt
    19321 gaatggtatg acacgcccat ccgtaaccag taccaccttt ccccaccaaa gggatggatg
    19381 aatgatccga atggattttg tgtttatcat gggtattatc atctgtttta ccagtttcac
    19441 ccattttctg aggagtggga taatatgtac tggggacatg cggtaagcca ggatttaatc
    19501 cactgggtac atcttccggt gtgtatggag ccgcagcagg agattttgaa ctatccggag
    19561 ctggtgggcg gcgctttttc agggacggca ttggttgacg aggagcagaa gctcagactg
    19621 ttttttacgc gccacatcgg aaagagaaga gataggacag ctttcaggga gtatcaggtg
    19681 atgacggaga gccgggacgg cctgaactgg gagcgggaga gccggattat tgaaggcccg
    19741 gagggccggg atttccggga cccgaaagta ttttatgaga atggagaata taagatgctt
    19801 atcggtatca ggggtgaaga gcatccggcc atatcccttt ataaatccta caatctggcg
    19861 cagtggacgt actgtggcga gatttttgag gaacaaaagg aggaggagaa ttttcctctg
    19921 gaatgtccgg atctcttccg tcttgacaac cagtgggtat tgactgccgg atactgcggg
    19981 catgtggacg ggcacggaag aaaaaacagc atctattacc acatcggaga atggtatcag
    20041 gatcagttcc atgaggaggc cagagggctt tatgattttg gcgcagattt ctatgcggtg
    20101 cagactatcg atacggagac cggacgggtg gctgtcggct ggatcagcga cgtggcaaag
    20161 gagcacgtca aatcgccaaa cggtgcgtgc ggaagtatga gcattccgag ggtacttcac
    20221 atcaaggacg ggaaacttta ccagaatccg gttcagggaa tctaccggct tatccgctac
    20281 ccggtctacg aaggatgcgg ggaggacgtg gaggttaccg gaattgaggg caacacctac
    20341 tatgtcaaat tagagatgga gaaaccatca gattttcgaa tgacacttta taagtggaaa
    20401 gacaggaagc tgtatctgga gcaaaaagat ggccagtgcc gtttccggac cgtgggagaa
    20461 ggagcaaaaa atattctcta tccggcggaa atcagtgatg ttaccacggt agaagtattt
    20521 gtggaccgga acgtgtgcga agtattctta aatgacggac aggcagcggg ggcgaagaaa
    20581 ttttaccagc agtcagagac cggaaacttt gagttccacg tacaggagaa aggcacagtg
    20641 aagtctctgg tagtagagaa aatggaggga atttggaaac agtgagaaag atcagggcag
    20701 tattatttga tatggacggc gtgctgattg acacagaaaa atatctgacc cgcttctgga
    20761 gacaggctgc ggcagaggcg gggcttcttt taagtcttga agagtgttat gcgttccgga
    20821 gctttgccgg gaaatatgcg gcgccctggt ttgccgaaaa atatggagag cagtatgact
    20881 actggacaat tagggagcgg agaaaggaac tgatgcaaga gcatatccgg gtacacggaa
    20941 tagagaaaaa ggatggcgtg gaagaggtgc ttcaagtcct tagccaggaa ggataccaga
    21001 cggcggtggt gacggcgaca gatgaaacga gagcgagaca gtatctaaga gatattggaa
    21061 ttttagagtt atttgatgct gtcatctgtg cgaatatggt agagcgtgga aagccgttcc
    21121 cggatgtgta cttgtacgcc tgtgaaaaga ttcagaacag aaagaaccgc aggactgtgt
    21181 ggcggtggag gattctccaa acggaatccg ggcggcgtat ggcgccggat gtcatgtggt
    21241 gatggtgccg gatttgacgc agccggacga ggagagccag aaccggatcg agagaaaggc
    21301 agcatctatc cgggatattc ccggagttgt ccgggaaatc agcagaggaa aattgcaata
    21361 cgggaggtaa agatggggat atttcggatt atcaggggcg atattacaca gtgcaaggtg
    21421 gatgcgattg tcaatgcggc aaatcc
//
