LOCUS       NZ_JADNBM010000009     29679 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Sellimonas intestinalis strain 1001217B_150727_G3
            NODE_9_length_141009_cov_57.6406, whole genome shotgun sequence.
ACCESSION   NZ_JADNBM010000009
VERSION     NZ_JADNBM010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Sellimonas intestinalis
  ORGANISM  Sellimonas intestinalis
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Sellimonas.
REFERENCE   1  (bases 1 to 141009)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 141009)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.75x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 02:59:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,087
            CDSs (total)                      :: 3,015
            Genes (coding)                    :: 2,958
            CDSs (with protein)               :: 2,958
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 5, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4 (16S)
            tRNAs                             :: 60
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 20 of 57
            Pseudo Genes (incomplete)         :: 33 of 57
            Pseudo Genes (internal stop)      :: 13 of 57
            Pseudo Genes (multiple problems)  :: 7 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:35:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 111330
            Orig. end                         :: 141009
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADNBM010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29679
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="2"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..29679
                     /SMILES="NC(CC(=O)N)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..29679
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:24482](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..24482)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     misc_feature    complement(600..609)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.14"
                     /tool="antismash"
     gene            complement(896..1852)
                     /gene="mraY"
                     /locus_tag="I2A62_RS08625"
     CDS             complement(896..1852)
                     /EC_number="2.7.8.13"
                     /GO_function="GO:0008963 -
                     phospho-N-acetylmuramoyl-pentapeptide-transferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="mraY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009248627.1"
                     /locus_tag="I2A62_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="WP_024732980.1"
                     /sec_met_domain="Glycos_transf_4 (E-value: 4.2e-38,
                     bitscore: 123.9, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTFVVPVLISFVLSVIMGPIVIPMLRKMKMKQTERVEGVESHL
                     QKAGTPTMGGVMILASIVVTSLFYVKDYPKIIPILFVTLGFGLIGFLDDYLKVVMKRSD
                     GLFPKQKFALQIVITAVFAYYLIHVTHTPLTLLIPFSGGRYWNIGWLAIPLLFIAVIGT
                     VNGVNFTDGLDGLASSVTVLVATFFTVVAVGTKSGIEPVTCAVVGALMGFLLFNVYPAS
                     VFMGDTGSLALGGFVASTAYMLQMPIFIIIVGMIYLIEVASVMIQVTYFKKTGGKRIFK
                     MAPIHHHFELCGWSETRIVAVFSIITAILCLIALLAL"
     gene            complement(1995..3743)
                     /locus_tag="I2A62_RS08630"
     CDS             complement(1995..3743)
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016439363.1"
                     /locus_tag="I2A62_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="penicillin-binding transpeptidase
                     domain-containing protein"
                     /protein_id="WP_195243241.1"
                     /transl_table=11
                     /translation="MKNKTYNKRKILIVFIGASLMILGLIARLCYLMIFDAEYYQKKAE
                     ALHEREREIKAARGEIIDRNGKVLATNKTVCTVSVIHSQIEDADAVTKALAGTLEMEEE
                     TVRKKVEKVSSMERIKTNVEKEVGDRIREMNLAGVKVDEDFKRYYPYEELASKVLGFTG
                     GDNQGIIGLEVKYEDYLKGENGMILSTTDARGVELEGIAEDRAEPTAGNTLRISIDYNI
                     QKYAQQMAQKVMEEKQAEKVAIILMNPQNGEIYAMVNWPEFNLNEPFELPEGTTYDSED
                     EKQELLNQMWRNGCINDTYEPGSTFKIITSSACLEEGVVDLDDTFVCPGYKIVEDRRIR
                     CHKVGGHGAETFVEGVQNSCNPVFMEIGLRLGAERFCDYFEQFGLMEKTGVDLPGEAST
                     IMHRLEDIGEVELATMTFGQSFQVTPVQMAATVSSLINGGKRVTPHFGVEVLDSESGKT
                     LKTFSDKQGRRVISEKTSETMRNILESVVSVGSGKNAYIEGYSIGGKTATSQTLPRSAN
                     KYISSFIGFAPAENPQILGMCVIYDPKGIYYGGTIAAPVVREIFDDVLPYLGIEKQENA
                     KSEKEE"
     gene            complement(3803..5599)
                     /locus_tag="I2A62_RS08635"
     CDS             complement(3803..5599)
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004605059.1"
                     /locus_tag="I2A62_RS08635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="penicillin-binding transpeptidase
                     domain-containing protein"
                     /protein_id="WP_243240178.1"
                     /transl_table=11
                     /translation="MKIKLVGVFTAIVLAFVFLAGKAVALNLVKGEEYQKQVMSQMRSG
                     SQIIHFKRGDILDTNDTVLATSERSYNVILDVAGLLETKTSYQNKKINATVEALVKGFD
                     LDESDLREILQDESDSRYVILKKDVDYETGKDFQTKMDKSKNIVSVTLEDSYTRTYPYG
                     TMASDVIGFTSSGNSGTIGLEAYYNNELNGTDGKKTGYLSSGSSSENVVKSPTDGNSIV
                     TTIDANLQAIVEKHILELNERLRDNYREGEGTKNTAVIIMDPNTGAILAEASYPNFDLN
                     QPRDLSKYYTTEEQEAMTEEERLETLNALWRNFCVSDTFEPGSTMKPFTMAAGFETGKL
                     TGDETYVCGGSYSYEGVAKPVSCIATDGHGTETLKQVLENSCNVGMMHIADTLGAEDFC
                     RYQHIFGFGEYTGIDLPGEGDTSNLLYTADNMQPIDLGTNAFGQNFNVSMTQLAAGFCS
                     LINGGNYYEPYLVKEIRNAQGDVVETKTPVLARKTVSQETCEILKDYMLGVVEEGSGKS
                     AQVEGYAIGGKTGTAEKLPRSQGKNLNSFIGYAPQENPEVMIYVVVDEPNLAQQAASYL
                     ATRLSADIMKEAFPYLNITKSE"
     misc_feature    5612..5626
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.57"
                     /tool="antismash"
     gene            complement(5684..6178)
                     /locus_tag="I2A62_RS08640"
     CDS             complement(5684..6178)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2A62_RS08640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="LapA family protein"
                     /protein_id="WP_024732983.1"
                     /transl_table=11
                     /translation="MASGKKRRTHNEAYMYDNLVRVRRPQIHQEAGYYEEEARTVSPQT
                     KKNQRRAMKLGFGYVTFFAGAVAVALFVCFHYLGAQADLEQKTRKIESLRTEITSLKEK
                     NTSEYNHIANSVNLDEVQQRAAELGMVYAEDSQIVKYQSAGDHKIRQYESIPEDGEATD
                     K"
     gene            complement(6226..7161)
                     /gene="rsmH"
                     /locus_tag="I2A62_RS08645"
     CDS             complement(6226..7161)
                     /EC_number="2.1.1.199"
                     /GO_function="GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008371903.1"
                     /locus_tag="I2A62_RS08645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="WP_024732984.1"
                     /transl_table=11
                     /translation="MAFEHKSVLLEEVVNGLNIKPDGIYVDGTLGGGGHAFEVCKQLSD
                     KGSFIGIDQDAAAIEAAGIRLRSFGEKVTIVRSNYCDMKLRLKELGIDKVDGIVLDLGV
                     SSYQLDTAERGFSYTKDAPLDMRMDTRQAKTAADIVNGYSEMDLFRIIRDYGEDRFAKN
                     IAKHIVMEREKGPITTTLELTEIIKASIPMKFQKMSGHPAKRTFQAIRIELNQELTVLR
                     ESLDEMIDLLNKGGRICIITFHSLEDRIVKEAFRRNENPCTCPSHFPVCVCGKKSKGKV
                     ITRKPILPGETETVENSRSKSAKLRIFEHI"
     gene            complement(7186..7623)
                     /gene="mraZ"
                     /locus_tag="I2A62_RS08650"
     CDS             complement(7186..7623)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0051302 - regulation of cell division
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mraZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008976470.1"
                     /locus_tag="I2A62_RS08650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="division/cell wall cluster transcriptional
                     repressor MraZ"
                     /protein_id="WP_024732985.1"
                     /transl_table=11
                     /translation="MLNGEFNHSIDTKGRLIIPSKFRESLGEHFVITKGMDGCLFVYPD
                     NEWSAFEDKLRELPLTNKKARDFKRFFLGSAVDGELDKQGRVLISSALRAYAGLEKEVV
                     LAGVLDKIEIWDKKAWDAHNEEVEADIDDIAGDMEDLGLRI"
     gene            8072..>8297
                     /locus_tag="I2A62_RS08655"
                     /pseudo=""
     CDS             8072..>8297
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611912.1"
                     /locus_tag="I2A62_RS08655"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSEKIIQLNEDLIKRSCS"
     gene            complement(8456..>9207)
                     /locus_tag="I2A62_RS16040"
                     /pseudo=""
     CDS             complement(8456..>9207)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015536544.1"
                     /locus_tag="I2A62_RS16040"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QKSLNLRKTKTDKVDTRTIAMLLLSDVNLKSYSETSYHNKELKSL
                     TRYRFDKVQERSQLK"
     misc_feature    complement(9194..9210)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     misc_feature    9208..9221
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.9"
                     /tool="antismash"
     gene            9522..10727
                     /locus_tag="I2A62_RS08665"
                     /pseudo=""
     CDS             9522..10727
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009266597.1"
                     /locus_tag="I2A62_RS08665"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS256 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTEGKRNIIHQLLEEYDIQSAEDIQEALKDLLGGTIKEMMEAEMD
                     DHLGYEKSERSDNDDYRNGYKTKQVNSRYGSMEIEVPQDRKSTFEPQVVKKRQKDISDI
                     DQKIISMYAKGMTTRQISETIEDI"
     gene            complement(10831..12026)
                     /locus_tag="I2A62_RS08670"
                     /pseudo=""
     CDS             complement(10831..12026)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1130: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611912.1"
                     /locus_tag="I2A62_RS08670"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS256 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDKIIQLNEDLIKHDLKDLVRSSVEETLNALLDKEADELVNAEK
                     YERSSDRQGYRSGYYKRNLHTTAGEVERKVPKLKGVPFETAIIERYRRRESSVEEALIE
                     MYLAGVSVRRVEDITETLWGTKVSPGTISNLNKKAYEHIETWSTRPLSGKYPYVYVDGV
                     YLKRSWGGEIQNVSVLVAIGVSQDGCREILGAAEGMKEDRESWRSIFVWLKERGFTGVH
                     LIIGDKNLGMLETIPEVFPDARYQRCTVYFYRNIFSVHPGTR"
     gene            complement(12436..13149)
                     /locus_tag="I2A62_RS08675"
     CDS             complement(12436..13149)
                     /NRPS_PKS="Domain: Thioesterase (5-230). E-value: 6.4e-40.
                     Score: 129.9. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08675_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.4"
                     /locus_tag="I2A62_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioesterase"
                     /protein_id="WP_195243242.1"
                     /sec_met_domain="PF00561 (E-value: 2.6e-06, bitscore: 20.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1.5e-39, bitscore:
                     129.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENRINLICIPHAGGNSSCFYKWQKYLEDNINLIPIELRGRGRRL
                     GEPLYQTMDEAIVDIFEQIRPIIKNGRYILFGHSMGSCIVYSVAQMIISQQYNEPKHIV
                     LSSVVPPKCEARCKTIHDADISVLRREVLKLGGTPREVFDNTDLASIFIPIIRADYKIL
                     ETFQATELPILECDLSVFYGSREDEVILKKISLWNSYTKKQCRYYKFDGDHFYLFNESI
                     RQVVETINLICSSLV"
     aSDomain        complement(12460..13134)
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08675_Thioesterase.1"
                     /evalue="6.40E-40"
                     /label="I2A62_RS08675_Thioesterase.1"
                     /locus_tag="I2A62_RS08675"
                     /protein_end="230"
                     /protein_start="5"
                     /score="129.9"
                     /tool="antismash"
                     /translation="NLICIPHAGGNSSCFYKWQKYLEDNINLIPIELRGRGRRLGEPLY
                     QTMDEAIVDIFEQIRPIIKNGRYILFGHSMGSCIVYSVAQMIISQQYNEPKHIVLSSVV
                     PPKCEARCKTIHDADISVLRREVLKLGGTPREVFDNTDLASIFIPIIRADYKILETFQA
                     TELPILECDLSVFYGSREDEVILKKISLWNSYTKKQCRYYKFDGDHFYLFNESIRQVVE
                     TIN"
     CDS_motif       complement(12877..12942)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08675_0001"
                     /evalue="7.00E-06"
                     /label="NRPS-te1"
                     /locus_tag="I2A62_RS08675"
                     /protein_end="91"
                     /protein_start="69"
                     /score="18.6"
                     /tool="antismash"
                     /translation="NGRYILFGHSMGSCIVYSVAQM"
     gene            complement(13195..13407)
                     /locus_tag="I2A62_RS15355"
     CDS             complement(13195..13407)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2A62_RS15355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_207734842.1"
                     /transl_table=11
                     /translation="MVYKEGNYEYDGTAFQNLIIKQSLEGEQAFILGCTELPIAVSLYH
                     IKGNLIDPSLCLVRAAIVRAGGGNS"
     gene            complement(13493..14653)
                     /locus_tag="I2A62_RS08680"
     CDS             complement(13493..14653)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0018455 - alcohol dehydrogenase [NAD(P)+]
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009245227.1"
                     /locus_tag="I2A62_RS08680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="WP_195243243.1"
                     /sec_met_domain="Fe-ADH (E-value: 4.1e-98, bitscore: 321.5,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNFTLNISTKVLFGKGMVKNLPKELSTYGSNILLVYGGGSIKKN
                     EVYQILMELLSEYDVSELAGVTPNPRIEDVRKGVRLARKNNVQVILAVGGGSVIDAAKL
                     IAAGYYYDDDSWDLVLCPGEIKKALPIITVVTCAGTGSEMNGSAVITNEEIEEKLGATS
                     VYMQPKVSILDPVYTYTVPAELTAAGVADTMSHIIESYFTKDEDTFIQNHMAEIMLKAC
                     IKYGPIAIEQSDNYEARANLLWASSLGLNGILGAGKATAWSCHPLEHELSACYDITHGV
                     GMAILLPKWMEYVLNDTTVAKFAEYARNVFDISEGDEYEMARNAINMTAEFFRKLRLPA
                     SLPEVGINDEKFEIMAKRAVTNGMLAFAYEPLKLEDVVKIYEMCLF"
     gene            complement(14681..15832)
                     /locus_tag="I2A62_RS08685"
     CDS             complement(14681..15832)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040521.1"
                     /locus_tag="I2A62_RS08685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="C45 family peptidase"
                     /protein_id="WP_207734843.1"
                     /transl_table=11
                     /translation="MYKIKKEILIAFMERGTLNYEYVFLEGDSYEVGRQRGEYLKKYPS
                     DMQYYTKPFYCDKATLTKNKIKEIRALYDEFCPGLNEEIEGFSDALHVSSDGVIFHTNL
                     YAVKGGCCHMVALPKVTENHHVLVGRSYEYSLDDDTRFTCCKINGKPAHIGFSVYLFGR
                     YEGINEHGLSITISAATPGTDTELSGLRFWTAIRCMIENCRTTDEAVYLLKHMPLSANT
                     NFIIADKQGNAVLAESSGLGNIRSLFTRQVVDYVVSTNHYNLPEMESFNVNRMNQSVMR
                     FQAANQSIKEHIPNVNESVIRDILQKKMPEGVCCHYYKDGLGTLYSIVADLTTMQIKVC
                     FGSANINKWYSINIHDERKGSWNIGVPYINEYPTNSEDFYRKV"
     misc_feature    16205..16221
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.3"
                     /tool="antismash"
     misc_feature    complement(16359..16372)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: strong, score: 23.25"
                     /tool="antismash"
     misc_feature    complement(16617..16635)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.2"
                     /tool="antismash"
     gene            complement(16784..17950)
                     /locus_tag="I2A62_RS08690"
     CDS             complement(16784..17950)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I2A62_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_195243245.1"
                     /transl_table=11
                     /translation="MLFIEQEKCANESSAQYSIRHAVEMLAGFQSVIPADTKDISSQDY
                     KEGELQFYQYITGLYVNLYKNPKVYKIDSEKYDEYMASNERKEKKGKFLVEKQHFQDSK
                     ESSLRNQFQQSISFYFKFLYELGCVSRIRMEDFSLEISKDSYRIACANTSMAKIRKDQK
                     ERIMILLNTGLGLRECGNSYIMTCEKYPKMFIGLVELCNAPDSKYKYMNYLRLDYKRIR
                     QPIPEIEDIMETLTEEMNGNINRLINALQDEKYKVKVKPLRNITSGFQWKVEFTVKGKS
                     CLGFYADRSSYLVCIYFNKHENISAMASYLEGKDKELFQWFCDHIPERLCRCPNNRWVT
                     LGSNRRRICGMSNRLDVVNPNAVDMKKCLKVLRIFRGYIGGYKDDIGY"
     gene            complement(17989..18237)
                     /locus_tag="I2A62_RS08695"
     CDS             complement(17989..18237)
                     /NRPS_PKS="Domain: PP-binding (8-78). E-value: 3.1e-10.
                     Score: 32.2. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08695_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="I2A62_RS08695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1493 family protein"
                     /protein_id="WP_195243246.1"
                     /sec_met_domain="PP-binding (E-value: 3.4e-12, bitscore:
                     39.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMERSKIEERVLSIIRDIVKDKDEDINITLQTDLKGIAGINSLEF
                     ISIMTSFEDEFSVIIDDDYIMKFFTAKDIVDYIQEQL"
     aSDomain        complement(18004..18213)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08695_PP-binding.1"
                     /evalue="3.10E-10"
                     /label="I2A62_RS08695_PP-binding.1"
                     /locus_tag="I2A62_RS08695"
                     /protein_end="78"
                     /protein_start="8"
                     /score="32.2"
                     /tool="antismash"
                     /translation="ERVLSIIRDIVKDKDEDINITLQTDLKGIAGINSLEFISIMTSFE
                     DEFSVIIDDDYIMKFFTAKDIVDYI"
     gene            complement(18265..19950)
                     /locus_tag="I2A62_RS08700"
     CDS             complement(18265..19950)
                     /NRPS_PKS="Domain: AMP-binding (28-463). E-value: 7.5e-84.
                     Score: 273.6. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08700_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="I2A62_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_195243247.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-89, bitscore:
                     293.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKTYSNPFYDWGIKLHSIKELVTYTGYQYSDNVAIRYKEKNEVI
                     EKTYKELLCDVQKTAKVLKNFDLQTGHVAILGRTSYDWIVSYLGIVYGGLVAVPLDTQL
                     NDAELAELMIRADVDCILGEERYVKNVQELVSDSNTINIIINESRERREGKEDFLSMDK
                     LRKEVQCIGTEEEIDPELLAVIVFTSGTTGKSKGVMLSHKNIITDVMSAKRILGLDEKD
                     SSLSILPLYHTYEMTCDILLMLYFGASVSLNDSLKYLSSNLKLMKPSVLFSVPMVVEQM
                     YQNIILAVKDQKKEKLFEVMIKVSSILRKMGFSCYKKLFANVREQFGGNLKLIVCGGSN
                     LDQDYIDFFDNIGINVVHGYGITECSPLLSANPDCCKKRYSVGPVVSCCQVKVDNSQNY
                     GCYNGHEVGEIMAKGDNIMLGYYNDTQGTREVMKGEWFKTGDIGYIDEDNYLFITGRVK
                     NLIILANGKNVSPENLESRLNKIDVIKEVVVSSRKINGSEHILATIFCDEQVVQEHQIS
                     DIKKYVDEQVTELNRTLPSYMQITSIEFRDKEFEKTSTKKIKRY"
     aSDomain        complement(18562..19866)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08700_AMP-binding.1"
                     /evalue="7.50E-84"
                     /label="I2A62_RS08700_AMP-binding.1"
                     /locus_tag="I2A62_RS08700"
                     /protein_end="463"
                     /protein_start="28"
                     /score="273.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QYSDNVAIRYKEKNEVIEKTYKELLCDVQKTAKVLKNFDLQTGHV
                     AILGRTSYDWIVSYLGIVYGGLVAVPLDTQLNDAELAELMIRADVDCILGEERYVKNVQ
                     ELVSDSNTINIIINESRERREGKEDFLSMDKLRKEVQCIGTEEEIDPELLAVIVFTSGT
                     TGKSKGVMLSHKNIITDVMSAKRILGLDEKDSSLSILPLYHTYEMTCDILLMLYFGASV
                     SLNDSLKYLSSNLKLMKPSVLFSVPMVVEQMYQNIILAVKDQKKEKLFEVMIKVSSILR
                     KMGFSCYKKLFANVREQFGGNLKLIVCGGSNLDQDYIDFFDNIGINVVHGYGITECSPL
                     LSANPDCCKKRYSVGPVVSCCQVKVDNSQNYGCYNGHEVGEIMAKGDNIMLGYYNDTQG
                     TREVMKGEWFKTGDIGYIDEDNYLFITGRVKNLIIL"
     CDS_motif       complement(18661..18732)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08700_0002"
                     /evalue="6.50E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="I2A62_RS08700"
                     /protein_end="430"
                     /protein_start="406"
                     /score="12.2"
                     /tool="antismash"
                     /translation="VGEIMAKGDNIMLGYYNDTQGTRE"
     CDS_motif       complement(19345..19404)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08700_0001"
                     /evalue="2.80E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="I2A62_RS08700"
                     /protein_end="202"
                     /protein_start="182"
                     /score="26.0"
                     /tool="antismash"
                     /translation="AVIVFTSGTTGKSKGVMLSH"
     gene            complement(20001..24482)
                     /locus_tag="I2A62_RS08705"
     CDS             complement(20001..24482)
                     /NRPS_PKS="Domain: Condensation_Starter (5-299). E-value:
                     2.4e-71. Score: 232.4. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08705_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (463-861). E-value: 3.5e-92.
                     Score: 301.0. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08705_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (971-1035). E-value: 1.9e-11. Score:
                     36.0. Matches aSDomain: nrpspksdomains_I2A62_RS08705_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1057-1335). E-value:
                     7e-23. Score: 73.0. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08705_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="I2A62_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_195243248.1"
                     /sec_met_domain="Condensation (E-value: 5.4e-60, bitscore:
                     195.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-99, bitscore:
                     326.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2e-06, bitscore:
                     21.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEKELYPLSEAQQRIWVTQMLNPESSMFTIGGYMLIKGAVEIEK
                     LQTSINHVIQKNKVFQTHIVKKADEYFQYYTTDSKKEIEHIDFCEKKADEKDFLEWIEQ
                     QARTAFPLENGFLYQFITFKKEEYLYGYLVKLHHVISDAWSFQLITDEISEEYEKLVKG
                     EEKQGTDEESEYDYVTYIEKEKEYLQSKQYEKYREYWVNKLTDLPIIRKTFSMQNQGKR
                     KEWIWSEEDTSRIRNYAKDTHFTLNAVLLAAYIIYLSKSLQSNDIVVGIPFSGRNMAMS
                     RHTVGMFVSSLPFRFHVDMGESFMQMVGRLQKELMICFKNHRFSYNRLVKELKLREQGQ
                     DGLYENCFNYYNVTLKTEIAGMEAVAKEFYNGEQDYVLQLIVRDWADGNQLEIDVDYKT
                     SVYQEEDIVQFFSQYRNIISAVAEKRDILVCDITMLSEEEYKMLVCDFNNTSSRYPSTE
                     TIIDLFEQQVRLTPNHIAVEDGTKLLTYEELNRKSDFIASELRKRCGNERRNIGLMTKH
                     SIETLIFILGIMKANCTFVPIDISYPSSRIQFMIKDASLHIIICDGEKEQIEKYGVEVL
                     YYQSCQMQLSELDKEESQQNQIRPEPGDLAYILYTSGTTGEPKGVMIEHKGLVNYIYWA
                     NKVYVRGDEMAFPFFTSLSFDLTITSIFTPLISGNKVVVYRDDQEVYVLNRIILDNLVS
                     IIKMTPTHLSLLVDMDCSKSKIERIIVGGEQLTAELCKTITEKFSHKIEIYNEYGPSEA
                     VVGCMIYQYDKEKDKGFAVPVGKPADNVKVFILDPSKKPMPLNGIGEMFISSPGLSRGY
                     LNKPELTKEKFIKSPFTKGERMYATGDLAKFIAPDCIEYCGRADQQIKLHGYRIELDEI
                     KNCLQKMRQIKDAVVIHKKNASGKEYLCCYYVKRESVTKQELVEYLTGELPGYMVPHLY
                     YELNEIPVTTNRKLNISALPEIEETAEKNESSTDYLDEKCKTLIEVLHSVFPNEHIEMQ
                     SDFYQLGGDSIQAIRISSQMLEYGFHLKASNILFSPIISDMVRYITKAVPDKEEEITDW
                     IEPTPIIAQFFDRNHPDRNYYHQSLLLELDQRVGVADLENVFQMLIKHHDILRMHLDRE
                     SQKLKYQSIGKEFKIIYYDLLDKPDNEKEETVRKIGIYEKSSIFIEDNYLFRVSFIRFS
                     KDKNLLLIVMHHLIIDGLSWGILLEDLESLLLQKNNGQQLKLPLKTSSFRKWSEYVKRE
                     ELNTQKYDLTAIEEFKKFYKRNTKVDESYLKNGKIECMLSKETTEKFIEEIGKNKTISE
                     LYVLADAVLTALEPLLGQDFLIDTEWHGRNTEYQELDLSRTIGWFTSIIPIHITNLDRD
                     EKERLRTIKEEMQKAKQLSVDPVFTGWYAKNRKKIQPIIKLNYLGNYSSVLKRELFCYA
                     SYDTGDDVSMNNYMENQLEINAIIIDSKLQITIYYSYSLCSEQKMQEICQKIPNHIEQI
                     TTFLREENPYCFTSMDFNTVNISTQELDSIFE"
     CDS_motif       complement(20472..20522)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0012"
                     /evalue="1.20E-07"
                     /label="NRPS-E5"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="1337"
                     /protein_start="1320"
                     /score="23.9"
                     /tool="antismash"
                     /translation="DLSRTIGWFTSIIPIHI"
     aSDomain        complement(20478..21311)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08705_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="7.00E-23"
                     /label="I2A62_RS08705_Condensation_LCL.1"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="1335"
                     /protein_start="1057"
                     /score="73.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHLIIDG"
                     /tool="antismash"
                     /translation="FFDRNHPDRNYYHQSLLLELDQRVGVADLENVFQMLIKHHDILRM
                     HLDRESQKLKYQSIGKEFKIIYYDLLDKPDNEKEETVRKIGIYEKSSIFIEDNYLFRVS
                     FIRFSKDKNLLLIVMHHLIIDGLSWGILLEDLESLLLQKNNGQQLKLPLKTSSFRKWSE
                     YVKREELNTQKYDLTAIEEFKKFYKRNTKVDESYLKNGKIECMLSKETTEKFIEEIGKN
                     KTISELYVLADAVLTALEPLLGQDFLIDTEWHGRNTEYQELDLSRTIGWFTSIIPI"
     CDS_motif       complement(20904..20969)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0011"
                     /evalue="2.40E-09"
                     /label="NRPS-E2"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="1193"
                     /protein_start="1171"
                     /score="29.5"
                     /tool="antismash"
                     /translation="LLIVMHHLIIDGLSWGILLEDL"
     CDS_motif       complement(21177..21278)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0010"
                     /evalue="4.50E-04"
                     /label="C2_LCL_024-062"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="1102"
                     /protein_start="1068"
                     /score="12.7"
                     /tool="antismash"
                     /translation="YHQSLLLELDQRVGVADLENVFQMLIKHHDILRM"
     aSDomain        complement(21378..21569)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08705_PCP.1"
                     /evalue="1.90E-11"
                     /label="I2A62_RS08705_PCP.1"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="1035"
                     /protein_start="971"
                     /score="36.0"
                     /tool="antismash"
                     /translation="TLIEVLHSVFPNEHIEMQSDFYQLGGDSIQAIRISSQMLEYGFHL
                     KASNILFSPIISDMVRYIT"
     aSModule        complement(21378..24467)
                     /complete
                     /domains="nrpspksdomains_I2A62_RS08705_Condensation_Starter
                     .1"
                     /domains="nrpspksdomains_I2A62_RS08705_AMP-binding.1"
                     /domains="nrpspksdomains_I2A62_RS08705_PCP.1"
                     /locus_tags="I2A62_RS08705"
                     /monomer_pairings="Asn -> Asn"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(21870..21932)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0009"
                     /evalue="4.90E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="871"
                     /protein_start="850"
                     /score="28.4"
                     /tool="antismash"
                     /translation="YCGRADQQIKLHGYRIELDEI"
     aSDomain        complement(21900..23093)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08705_AMP-binding.1"
                     /evalue="3.50E-92"
                     /label="I2A62_RS08705_AMP-binding.1"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="861"
                     /protein_start="463"
                     /score="301.0"
                     /specificity="substrate consensus: Asn"
                     /tool="antismash"
                     /translation="FEQQVRLTPNHIAVEDGTKLLTYEELNRKSDFIASELRKRCGNER
                     RNIGLMTKHSIETLIFILGIMKANCTFVPIDISYPSSRIQFMIKDASLHIIICDGEKEQ
                     IEKYGVEVLYYQSCQMQLSELDKEESQQNQIRPEPGDLAYILYTSGTTGEPKGVMIEHK
                     GLVNYIYWANKVYVRGDEMAFPFFTSLSFDLTITSIFTPLISGNKVVVYRDDQEVYVLN
                     RIILDNLVSIIKMTPTHLSLLVDMDCSKSKIERIIVGGEQLTAELCKTITEKFSHKIEI
                     YNEYGPSEAVVGCMIYQYDKEKDKGFAVPVGKPADNVKVFILDPSKKPMPLNGIGEMFI
                     SSPGLSRGYLNKPELTKEKFIKSPFTKGERMYATGDLAKFIAPDCIEYCGRADQQIKL"
     CDS_motif       complement(22014..22103)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0008"
                     /evalue="2.20E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="823"
                     /protein_start="793"
                     /score="36.0"
                     /tool="antismash"
                     /translation="PLNGIGEMFISSPGLSRGYLNKPELTKEKF"
     CDS_motif       complement(22608..22667)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0007"
                     /evalue="8.60E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="625"
                     /protein_start="605"
                     /score="33.6"
                     /tool="antismash"
                     /translation="AYILYTSGTTGEPKGVMIEH"
     CDS_motif       complement(22866..22907)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0006"
                     /evalue="1.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="539"
                     /protein_start="525"
                     /score="12.1"
                     /tool="antismash"
                     /translation="LGIMKANCTFVPID"
     aSDomain        complement(23586..24467)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08705_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="2.40E-71"
                     /label="I2A62_RS08705_Condensation_Starter.1"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="299"
                     /protein_start="5"
                     /score="232.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHVISDA"
                     /tool="antismash"
                     /translation="LYPLSEAQQRIWVTQMLNPESSMFTIGGYMLIKGAVEIEKLQTSI
                     NHVIQKNKVFQTHIVKKADEYFQYYTTDSKKEIEHIDFCEKKADEKDFLEWIEQQARTA
                     FPLENGFLYQFITFKKEEYLYGYLVKLHHVISDAWSFQLITDEISEEYEKLVKGEEKQG
                     TDEESEYDYVTYIEKEKEYLQSKQYEKYREYWVNKLTDLPIIRKTFSMQNQGKRKEWIW
                     SEEDTSRIRNYAKDTHFTLNAVLLAAYIIYLSKSLQSNDIVVGIPFSGRNMAMSRHTVG
                     MFVSSLPFRFHVD"
     CDS_motif       complement(23598..23687)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0005"
                     /evalue="6.60E-09"
                     /label="C5_LCL_267-296"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="295"
                     /protein_start="265"
                     /score="28.2"
                     /tool="antismash"
                     /translation="DIVVGIPFSGRNMAMSRHTVGMFVSSLPFR"
     CDS_motif       complement(23694..23726)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0004"
                     /evalue="1.40E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="263"
                     /protein_start="252"
                     /score="-0.4"
                     /tool="antismash"
                     /translation="AYIIYLSKSLQ"
     CDS_motif       complement(24015..24077)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0003"
                     /evalue="1.10E-06"
                     /label="C3_LCL_132-143"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="156"
                     /protein_start="135"
                     /score="21.2"
                     /tool="antismash"
                     /translation="LHHVISDAWSFQLITDEISEE"
     CDS_motif       complement(24315..24401)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0002"
                     /evalue="1.50E-03"
                     /label="C2_starter_024-063"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="56"
                     /protein_start="27"
                     /score="11.2"
                     /tool="antismash"
                     /translation="MFTIGGYMLIKGAVEIEKLQTSINHVIQK"
     CDS_motif       complement(24423..24464)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08705_0001"
                     /evalue="1.60E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="I2A62_RS08705"
                     /protein_end="20"
                     /protein_start="6"
                     /score="11.3"
                     /tool="antismash"
                     /translation="YPLSEAQQRIWVTQ"
     gene            complement(24518..27556)
                     /locus_tag="I2A62_RS08710"
     CDS             complement(24518..27556)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_function="GO:1904680 - peptide transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01194.1"
                     /locus_tag="I2A62_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cyclic peptide export ABC transporter"
                     /protein_id="WP_207734844.1"
                     /transl_table=11
                     /translation="MTDETSKTATSTSVDKEFIQKVDDLVKKTLRKAKVPGASLALVRG
                     DEVIYRTYGYEDREMQEQIGEDTLFELGSMSKAFTGLGILLLEQEGKLSIDDPVKEYIP
                     WLSFSYDGDTNLDNDMTIANLLYHTSGIPFQTIGYIPEGTAEDSLEKTVKMVNGVKLDF
                     YPGEKYQYATVNYDILAYIIQSVTGELYETFMEQEILDKLGLSDTHMYRYDEEVEDRIA
                     QGYKFQFLREVASNPPAYRGNTAAGYIVSSIQDMARWMQIQMGIVEIPEELTQLIMKSH
                     QGNTKVVAEGDKFYGSGWLIDMNGDIIKHGGSNPTFSSMLEMQGKDQFGVCILTNIDSN
                     AAEYIADSIIKIYNGESVAKYKADFYKSSDMFFSIIIIVSIVVILLYAVVLLKALIDIF
                     KKKRIHVKAKDMKLASIFFVIPLLIFTGLCTYNLPKILFERLPWSAVGVWASKTVIWGC
                     ILVYIAIVVFMLYISLTFNFTKDGEKNYMALIPISVVNGVASALIIFTINETFNRNLQY
                     SKELLLYFIFSIVVFVYSIKLLQGKMIYITNELIYNKRIQMIEKILQAPYQKIESLGQE
                     RIYSGLNNDTSAVSEMPNVVVNLVSNMLTIVFCLLYLTVKSTYAFLASTAIVLLNGLIS
                     IITNRIATKYWEKNRDIQETFFGQMRDLVYGFKELCFNCFRKKDFKQEMEQYTRKSADF
                     SKAASLKLLNFNMYNVLMYNLVFGVVVFIFPLLIKGISVNTLRENLFIVFYLIGPFEAL
                     ATAISKYAQIGVNMKRINKLLEELEQSSVESQEVMERPAIEPDKKLTIQLKDVIYHYII
                     KDEVKDDRKFMLGPINAEFQTGQITFIIGGNGSGKSTLGKLVSGLYCKEDGEILVNGKS
                     VEQLTLLGCFTAVYSDFHLFQKLYGIPYQERKEEVASYLELLKIEDKVHIKDNGAFESL
                     SLSTGQKKRLAFVISCLDDKPMMIFDEWAAEQDPVFRDYFYMQLLPMLKKKGKGVIVIT
                     HDDNYFNTADQIIKLDCGKIVES"
     gene            complement(27663..27911)
                     /locus_tag="I2A62_RS08715"
     CDS             complement(27663..27911)
                     /GO_function="GO:0000035 - acyl binding [Evidence IEA]"
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0009245 - lipid A biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 7.4e-14.
                     Score: 43.8. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08715_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="I2A62_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="WP_195243250.1"
                     /sec_met_domain="PP-binding (E-value: 2.2e-11, bitscore:
                     37.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNDIRERFKKVIAQTLEIQPENINLEAKLQDLGANSYYYLRIVV
                     ALEDEFGFEFSDDQLDYEKFETVMEIVNYVEKLIQND"
     aSDomain        complement(27687..27890)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08715_PP-binding.1"
                     /evalue="7.40E-14"
                     /label="I2A62_RS08715_PP-binding.1"
                     /locus_tag="I2A62_RS08715"
                     /protein_end="75"
                     /protein_start="7"
                     /score="43.8"
                     /tool="antismash"
                     /translation="RFKKVIAQTLEIQPENINLEAKLQDLGANSYYYLRIVVALEDEFG
                     FEFSDDQLDYEKFETVMEIVNYV"
     gene            complement(27941..29614)
                     /locus_tag="I2A62_RS08720"
     CDS             complement(27941..29614)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: TIGR01720 (91-222). E-value: 1.9e-24.
                     Score: 78.2. Matches aSDomain:
                     nrpspksdomains_I2A62_RS08720_TIGR01720.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="I2A62_RS08720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_195243251.1"
                     /sec_met_domain="Condensation (E-value: 7.5e-15, bitscore:
                     47.7, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTRKDFAIVLSEEETQQVCLKASEQFVSMEHIMLGCVVMALRK
                     LLHKEHLVVEMEGHGRGDVSENLNITRTVGWFTSVYPVLIDITEDNINSYIEKIAETLS
                     AVPSGGLSYGVLKYLSKDGLGESLDIAADIRFNYLGEFDQNLNSEFMSISNFDFGYTVD
                     PDYPVDFLFDINSIIIENKLRINLNYIESLTKIENLKLFDEIFRNSIREFIAEQNKRTD
                     LEVQYESYQYIEGIKPFNDLIYKDCFYNALFPVFQYYQKDIRSILANDMFVYTTQDDSQ
                     NIDAEYILSEKMLNVLSKSGLKINRIVHSNDIITNIKGAISEKKLVIIRVDCYFISTRE
                     DTYNKEHWPHTLLVYGYDDKNEAVYVLDQSDKNTLDFSERKINYCEIIDAYVGIKENFI
                     IDKEYPSYMDIQLASKKVKESSKTEYVEIIKRNLLKHQNEKMQGFDILSKFIENFDKVI
                     QDEETFKKASSGYLYSFGNILKIQTAALFRLTRIFPEDFIDRKTLEELVRGWRYAKNII
                     EKYSLTGRYRKDSLSTTTVKLKELCEVEKSFTQNLIASLS"
     aSDomain        complement(28949..29341)
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I2A62_RS08720_TIGR01720.1"
                     /evalue="1.90E-24"
                     /label="I2A62_RS08720_TIGR01720.1"
                     /locus_tag="I2A62_RS08720"
                     /protein_end="222"
                     /protein_start="91"
                     /score="78.2"
                     /tool="antismash"
                     /translation="INSYIEKIAETLSAVPSGGLSYGVLKYLSKDGLGESLDIAADIRF
                     NYLGEFDQNLNSEFMSISNFDFGYTVDPDYPVDFLFDINSIIIENKLRINLNYIESLTK
                     IENLKLFDEIFRNSIREFIAEQNKRTD"
     CDS_motif       complement(29258..29314)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08720_0002"
                     /evalue="5.30E-06"
                     /label="NRPS-E6"
                     /locus_tag="I2A62_RS08720"
                     /protein_end="119"
                     /protein_start="100"
                     /score="18.9"
                     /tool="antismash"
                     /translation="ETLSAVPSGGLSYGVLKYL"
     CDS_motif       complement(29363..29407)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I2A62_RS08720_0001"
                     /evalue="2.10E-08"
                     /label="NRPS-E5"
                     /locus_tag="I2A62_RS08720"
                     /protein_end="84"
                     /protein_start="69"
                     /score="26.2"
                     /tool="antismash"
                     /translation="ITRTVGWFTSVYPVL"
ORIGIN
        1 gctgctatcg ccaccgccgc catcacattt tcataattat gggttccaag cagcatgagc
       61 tcctccacac ggcaaaccgg aactacttcc tgattccggt agataatctc cccgtctttt
      121 aagtaaatcc ccaccggaag ttccctttta ctactaaaat aaaatggtgt cgcttctgtc
      181 tcttccccga acacccggag cacgtcatct tcataattca gcacacagta gtcatccttc
      241 gtctggtttc ttgtaatggc ctctttggcg ctgatatagt tctccatggt gtggtgtctg
      301 ttcagatgat ccggcgtaat atttaagatc gcgctgatct tcggcgcaaa cccatgaatc
      361 gtctccagct ggaaactgct gatctccgca acagttacac tttgctctgt catcttcata
      421 gcctccatgg tgtacggatt accgatattt ccaactacaa acacctcact ttgatgagcc
      481 ttcataatct caccaagaag tgtcgtggtg gtcgtctttc cattcgtccc cgtaatagcc
      541 agtacatctc ccctgccata gtgatatgca agctcgattt ctccccagat caggatcccg
      601 tccgccttca tcttctccac aaccggaaga tccactggaa tacccggact taaaaccgca
      661 agaccgattt tttccatctg atcctccgga aacggtccga atattatttc cgccttactg
      721 tcctttggca gacgtctccg gatttcttcc ggatcgagtt tttcatttcc atcatataag
      781 atcgtatcaa cgccctcgtg ctccagaagc atcaccgcac caatcccact ctttccagag
      841 ccgaacacga gtaccttttt cccgtttttt aacattactc ttccgtcctt tcttcttata
      901 gtgccaacag cgcaatcaga cacagaatcg ccgtgataat ggaaaagact gccacgatcc
      961 tcgtctcaga ccatccacag agctcaaaat gatgatgaat cggagccatc ttaaaaatcc
     1021 gttttccacc tgtcttctta aaataagtaa cctgaatcat caccgacgcc acctctatca
     1081 gataaatcat tccgacaatg atgatgaaaa tgggcatctg aagcatatat gccgtggacg
     1141 ccacgaatcc tccaagagcc agagatccgg tgtctcccat aaacacactg gccggataga
     1201 cattaaacag aaggaatccc ataagcgcac ctaccaccgc acaggtgacc ggctcaatcc
     1261 cactctttgt tcctactgcc accaccgtaa agaatgtagc aacaagcacg gtcacactgg
     1321 aggcaagccc atcgagtcca tctgtaaaat tgacgccgtt gaccgtaccg atcactgcta
     1381 taaataacag cggaatggca agccatccta tattccagta tcttccacca gaaaatggaa
     1441 tcagaagggt caacggtgta tgagtaacat ggatcagata ataggcaaat accgcagtta
     1501 tcacaatctg aagggcgaac ttctgctttg gaaagagtcc gtccgagcgc ttcatcacaa
     1561 ccttgagata atcatccaga aatccgatca gtccaaaccc aagcgttacg aacaagatcg
     1621 gaataatctt cggataatcc tttacataaa agagggaggt aactacaata gaagccagaa
     1681 tcatcacgcc tcccatggtc ggcgtccccg ccttctgtag atgagactcc accccctcca
     1741 cacgttctgt ctgtttcatt ttcattttcc gtaacatcgg aatcacaatc ggccccataa
     1801 tcacactcag tacaaatgag atcagaaccg gtactacgaa tgtaaaatcc atatctgcac
     1861 ctcttcatcc tttggtttct aaacaggcct atatgcctgc gtaccattat aacgtatttg
     1921 taccatcaat gcaagtcgac cgccatggct cgctctttct ttctgccgca ggctgctctt
     1981 cttttctgtc acggtcactc ttccttttca gactttgcgt tctcttgttt ttcgatgcca
     2041 aggtacggca gtacgtcatc aaaaatctcc cgcacaaccg gggctgcgat cgttccgcca
     2101 taatagattc ccttagggtc gtagataaca cacattccca gaatctgcgg attttcggcc
     2161 ggagcaaagc caataaagga agaaatatat ttgttggcgc ttcttggcag agtctgggac
     2221 gtggccgtct ttcctccgat actgtatccc tcgatatagg cgtttttccc ggatccgact
     2281 gaaaccacgc tctccaggat gttccgcatc gtctctgacg ttttctcaga tatgaccctt
     2341 ctgccctgtt tatccgaaaa tgtcttaagc gtcttcccgc tctcactgtc cagcacttct
     2401 accccaaaat gaggcgttac cctctttcct ccattgatca aggaactgac tgtggcggcc
     2461 atctgtaccg gcgtcacctg gaacgactga ccgaatgtca tggtagcaag ctctacctcc
     2521 ccgatatctt ccagccggtg catgatagta gaagcctccc ccggaagatc caccccggtc
     2581 ttttccatca gcccgaactg ttcgaaatag tcacagaacc gttccgctcc aaggcgtagt
     2641 ccaatttcca tgaaaaccgg gttacaggaa ttctggacgc cctccacaaa cgtctcggca
     2701 ccgtgcccgc ctaccttgtg gcaccggatc ctccgatcct ccacgatctt gtatcccgga
     2761 cagacaaacg tatcatccag atcaacgacc ccctcctcca gacaggcgct ggaggtgatg
     2821 attttaaagg tagaacccgg ctcataggtg tcgttgatac acccgtttct ccacatctgg
     2881 tttaaaagtt cctgcttttc atcctccgaa tcatatgtcg ttccctccgg aagttcaaat
     2941 ggttcgttca gattaaactc cggccagttc accatagcat agatctctcc gttctgcgga
     3001 ttcatcagga tgatcgccac cttctccgcc tgcttttcct ccattacctt ctgcgccatc
     3061 tgctgggcgt acttctgaat gttataatcg atgctgatcc gcaaggtatt gccggcagtc
     3121 ggctctgccc ggtcctctgc gatcccctcc agctccacgc ctcttgcgtc cgtagtggag
     3181 agaatcattc cattttctcc tttcagataa tcttcgtact tgacctccag tccgataatc
     3241 ccctgattat caccccctgt gaagccaagc accttgctgg caagctcttc gtacggataa
     3301 taccgtttga aatcttcatc caccttgacg cctgccagat tcatctcccg gatccggtct
     3361 ccaacttctt tttccacgtt ggttttgatt cgttccatag aggaaacttt ctccaccttt
     3421 ttccgtacgg tttcttcctc catctccagt gtcccggcaa gagctttcgt cactgcgtcc
     3481 gcatcctcga tctgactgtg aatcaccgaa acggtacaga ccgtcttatt ggtagcaagt
     3541 actttaccgt tccggtcgat aatctctcct cttgccgcct tgatctcccg ctcccgttcg
     3601 tggagagcct cggccttctt ctgataatat tccgcgtcaa aaatcatcag ataacaaagt
     3661 cttgcaatca gccccagtat cattagcgac gccccgataa acacaatgag aatcttcctt
     3721 ttattatagg ttttattctt cataaaaaac ctcacagaag tgattgatat agcttattaa
     3781 tccttctgtg aggttattct atttattccg attttgtaat attcaaatat ggaaatgctt
     3841 ctttcataat gtccgcagaa agtcttgtcg ccagataact tgccgcctgc tgtgccagat
     3901 tcggctcgtc cacaacaacg tatatcataa cttccggatt ttcctgcggg gcatatccaa
     3961 tgaaagagtt taagttcttt ccttggcttc gaggcagttt ctccgcagta ccggtctttc
     4021 cgccaatagc atacccctct acctgggctg attttccact tccctcttct acgactccaa
     4081 gcatatagtc tttcagaatc tcgcacgttt cctgggatac ggtttttctt gccagcaccg
     4141 gagtcttcgt ctccacaacg tccccctgag cattgcggat ctctttcacc agatacggtt
     4201 catagtaatt acccccattg atcagtgagc aaaaccccgc cgcaagctgt gtcatcgaca
     4261 cattaaaatt ctgtccaaaa gcgttggttc ctagatcgat gggctgcatg ttatcagccg
     4321 tgtacagaag attggatgta tccccctctc caggcagatc aatgcctgtg tactctccaa
     4381 aaccaaagat atgctgatac cggcagaagt cctccgcgcc gagtgtatct gcaatatgca
     4441 tcattccgac gttgcaggaa ttttccagca cttgttttaa tgtttctgtc ccatgtccgt
     4501 ctgtggcgat acaggaaacc ggcttggcaa ctccttcata ggaataggaa ccgccgcata
     4561 catatgtctc atctccagtc agtttgccgg tctcaaatcc ggccgccatc gtaaacggct
     4621 tcatcgtgga tcccggttca aacgtatcgc tgacgcagaa gtttctccac agcgcattaa
     4681 gtgtctccag acgctcctcc tcagtcatgg cctcctgctc ctctgtcgta taatatttcg
     4741 acagatccct tggctgattc agatcaaaat tcgggtaact tgcctcagcc agaatagctc
     4801 cagtgtttgg atccattatg atcacggctg tgtttttcgt accctcgccc tcacggtagt
     4861 tatcccgcag cctttcattt aattccagaa tatgcttctc cacgatcgcc tgcagattcg
     4921 cgtcaatcgt tgtgacaatg gaattgccgt ccgtcgggct tttcactacg ttctctgagc
     4981 tggatccaga cgagagatac cctgtttttt ttccatctgt tccgttcagt tcgttattat
     5041 aatatgcctc cagaccgatc gttccgctgt ttcctgagga agtaaatccg atcacatcac
     5101 ttgccatggt tccgtagggg taggttctcg tataggaatc ttccagtgtc acactgacaa
     5161 tatttttgct cttatccatc ttcgtctgaa aatcttttcc ggtctcataa tccacatctt
     5221 ttttcaagat cacatagcga ctgtccgact cgtcctgcaa aatctccctg agatctgact
     5281 catccaagtc aaaccctttg acaagtgctt ccactgtggc attgatcttc ttattctgat
     5341 aggacgtctt cgtctccagg agtcccgcca catcgagaat cacgttgtag gaacgctcgc
     5401 ttgtagccag aactgtatca tttgtatcca gaatatcgcc acgtttaaag tggatgatct
     5461 gactcccgct tcgcatctgg ctcataacct gcttctggta ctcctcccct ttgacaagat
     5521 ttaaggcaac tgcctttcct gccaaaaaaa caaaagccag tacgattgcc gtaaacactc
     5581 ctaccagctt tattttcatt cttttcggaa attttttatg aaaattctgg gattcttttt
     5641 gagttctctt tctttccatg gaattcccct tttcactatg ctgttattta tccgttgctt
     5701 ctccatcttc cggaatgctt tcgtactgtc tgattttatg atctcctgcg ctttggtatt
     5761 tcacaatctg ggaatcctcc gcatatacca taccaagctc cgctgccctt tgctgaacct
     5821 cgtccagatt gacggaattt gcgatatgat tgtattctga tgtatttttc tctttcaggc
     5881 tggtgatctc tgtccgcaga ctttcaattt ttcttgtctt ctgttccaaa tccgcctggg
     5941 ctccaagata atgaaagcag acaaatagtg cgaccgccac cgccccggca aaaaatgtca
     6001 cataaccaaa gccgagcttc attgccctgc gctggttctt tttcgtctgc ggactcacag
     6061 tcctggcctc ctcttcgtag tatcctgcct cctgatgtat ctgcggtcgt ctgacccgga
     6121 caagattatc atacatatat gcttcgttat gtgttcttcg tttctttcct gatgccatac
     6181 acgttccctc ttttctgtgt ctggtacttc acacgatgtt tcgtatcaga tatgctcgaa
     6241 aatacgaagc ttcgcgctct ttgatctgct gttttccact gtctctgttt cccccggaag
     6301 aattggcttt ctcgtgatca cctttccttt tgacttcttc ccacatacac acactggaaa
     6361 atggctcgga caggtgcacg gattctcgtt tctgcgaaac gcttccttta caatccgatc
     6421 ttccagtgaa tggaatgtaa taatgcagat ccttccacct ttattaagta agtcaatcat
     6481 ctcatccaaa gattccctta aaactgtcag ttcctgattc agctcaatcc ggatcgcctg
     6541 aaacgtcctc ttggccggat gacccgacat tttctgaaat ttcattggga tcgatgcttt
     6601 tataatctct gtaagttcta aagtggttgt aataggacct ttttcccgtt ccattacaat
     6661 gtgctttgcg atgttcttcg caaatctatc ttctccgtaa tcacgaatga tgcgaaaaag
     6721 gtccatctca ctgtatccat tgacaatatc agcggctgtc tttgcctgcc gggtgtccat
     6781 ccgcatatca agcggcgcat cctttgtgta tgagaatcca cgctctgccg tatccaactg
     6841 ataagacgat acgcccagat cgaggacaat cccatccact ttgtcaatgc ctaattcttt
     6901 tagccgcagc ttcatatcac aatagttgct ccttacgatt gtgactttct ccccgaaact
     6961 gcgaagccgg attcctgccg cttcaatcgc ggcggcgtcc tggtctattc cgataaaact
     7021 ccccttgtca cttaactgct tacatacttc aaaagcatgt ccgcctccac caagcgttcc
     7081 atctacgtaa atgccgtctg gcttgatgtt cagaccattt acgacctctt ctaataatac
     7141 tgatttgtgt tcaaatgcca tggtttcctc cttcacctgc tacacctaaa tgcgaaggcc
     7201 cagatcttcc atgtcgccgg cgatatcatc gatatccgcc tccacttcct cattatgtgc
     7261 atcccaggct ttcttgtccc agatttcaat cttatcaagg acacctgcca gtaccacttc
     7321 cttttccagt ccggcataag ctctcagggc agaagagata agtactcgac cttgcttgtc
     7381 aagttcgcca tcgacagcgc ttccaagaaa gaaccgtttg aagtctctgg cttttttgtt
     7441 ggtaagtggt aattcccgga gcttatcttc aaaggcgctc cattcattgt ccggatacac
     7501 aaataaacag ccgtccattc cctttgttat cacgaaatgt tctcccagac tttcgcggaa
     7561 cttagaaggg atgatgaggc ggccttttgt gtcaatgcta tgattgaatt ctccgttcaa
     7621 catgcaactc accttcttcc aaaacgggga tgtcttcccc cattttgtac cactactctc
     7681 cactttctac cacttgaaac cattgtaaac cacacaacta cctttttcaa gtactttttc
     7741 caaaatgatt cttaataatt tcttacctcc tttgaccctt ttcgacactc atttcacaca
     7801 attaccggaa gctctgaaag ccataccctg ggatgataca cagtttccaa ggttcttggc
     7861 atgcccaggc tttagctcgc cgccattata aaaaacaatc gctttgtagg attctccgcc
     7921 tgcggtgggc tgctctagcg acactttcca attcgccgga taacgtatta ttaatttcgc
     7981 aaaatcaatt tcataaaaac agacatggtc tatagccgtt tggtaaaatt aagtcaccac
     8041 aaccgaatcc atcaaaggag gctatagaac catgtctgaa aagattatac agctaaatga
     8101 ggacttaata aagcgatctt gttcgtaaca gtgtcgaaga aactttaaac gccctgcccg
     8161 ataaggaagc cgccaaatta gtcaatactg aaaagtatga gcgctcctct gatcgccagg
     8221 gatatcgttc cggtcattat aagcggaatc tccacacaac cgcaggggaa gtggaactga
     8281 aggttcttaa actgaaagac taactattaa agtcaagtct gaaataaaga ttttgtgaat
     8341 gaattgcgga aacacatttc agatatcgtt gtaccttaaa aatcgcataa taaacagagc
     8401 atcatatacc ggtgctcaat gggagtgtta tggaacagaa aaaggttttg cttttttatg
     8461 taaggcttac cggttttccc atttcataaa tcagccgcac gagtttcttt gtaacgtggg
     8521 tgatggcaac attgtagtgt atctcttcag aaatttattt ctgaagagat acgccgaatg
     8581 tttcgcccaa tggcagacgc acttggcagc attaatgaga gcaaagcgaa gtagcgagac
     8641 ccccgctttt ccatgtggga ataagaggat tccaactgcc cggattgata ggtagatgcg
     8701 gaagctccgg cgtacgccag gatcttatcc ggtgaatcaa aacgggaaaa tccccgatct
     8761 cgccaaggat catggcaccc atgcggtaac caatgccgag gatagtcagg attggagaag
     8821 cgatctgatc catgatccgt ttgatctcag attcgatctc tgcaatctcg gagtccagtt
     8881 cgccgatcag tttgagagta tgtctcagtt ccaggaattt cgcgggtatg ctggagccaa
     8941 tggaggttct tgcggcatcc cgtatttcaa tcgctgtatc tcgatggtaa cgacctttcg
     9001 aatggtgaca agccaggaga cagactactt gagctgggag cgttcctgaa ctttatcgaa
     9061 acggtaacga gtgagtgact ttagctcctt gttgtgatat gacgtttctg agtaggactt
     9121 caagttcaca tcagacaaga gcaacatagc aatggttcgg gtatcaacct tatccgtttt
     9181 cgtttttcta aggttgagac ttttctgcaa agatttgttt ggagagaatt cttactgtgt
     9241 ggccttatag aaccacttat ttgtgcttga aagatggaac ttacactgat ttctatgctg
     9301 tctaaaactg aagaaagtct ttacgactca cctgcccgtg ttttgttgtg tagcttcttt
     9361 aagaactatt ttatcaataa cgtagaggat tgaaagattt tcattactat ttgtgccacc
     9421 aactaaaagg cggaggaatg gagacttcta tgataaaatc taattcatag gagggccttt
     9481 tagttatggc aaaacaatag aaacctgtac acagagtaca aatgacagaa ggaaaacgca
     9541 acattatcca tcagctcctg gaggaatacg acattcaatc agcagaggat atccaggaag
     9601 ctttgaaaga tcttctcggt ggaacaatca aagaaatgat ggaagctgaa atggatgatc
     9661 acctcggata tgaaaaatct gagcgttcag acaatgatga ttaccgaaat ggctataaga
     9721 ccaaacaagt caacagcaga tatggaagta tggagatcga agttcctcag gatcggaaat
     9781 ctacttttga acctcaggtt gtaaagaaac gtcagaaaga catttcggat atcgatcaaa
     9841 aaatcatttc catgtatgca aaagggatga ccacacgaca gatttcagaa accatcgaag
     9901 atatttaggg ctttgaaact tcagagggat ttatttctga tgttacagat aagattcttc
     9961 ctcagattga agactggcag aacagaccac ttgatgatgt atatccaatc ctctttattg
    10021 atgcgatcca ttattctgtg cgcgataatg gagttatccg taagctggcc gcatatgtga
    10081 tccttggcat caatacgaaa ggcaaaaagg aagtacttac catccaggtt ggagacaacg
    10141 agagttcaaa atactggctt tctttattaa atgaactaaa aaatcgaggt gtaaaggata
    10201 tcctgatcct ttgtgcggat ggacttacgg gaataaaaga agccattgct gcggcatttc
    10261 cccaaacaga atatcagaga tgtatcgttc atcaggtgag aaacacgcta aaatatgttc
    10321 cggataaaga tagaaaagta ttcgccacag atttaaaaac aatctatcag gctgcggatg
    10381 agaaaaatgc tttagcagcc ttggaacgtg tgactgaaaa atggactaca aagtatccga
    10441 attctatgaa acgctggaaa gataactggg atgcccttgc tccaatcttt aaattttcag
    10501 cagtcgtcag aaaggtgata tacacgacaa atgcgataga atccttgaat tctacctatc
    10561 ggaagcttaa tcgccagaga agcgtatttc ccagtgatac atcccttttg aaggctttgt
    10621 atctggccac atttgaagcc acgaaaaaat ggacatctac gcttcggaac tgggctcagg
    10681 tatatggaga attgagtatt ttgtacgaag gaatgctgcc ggaataatat taagaatcgc
    10741 taaaaaacag gcggaaaaac cgcctgctct tgacagatag tgtcaatagt ttttcgcaaa
    10801 atcagaacct agccgtttgg cagccggtag tcagccggct atgatatcag acagcagatc
    10861 ctcttctgat ttgaaaagat gatccatatt catatagcgt ctggctcccc aactggttgc
    10921 tgctacatga cgcagtctgg cacataccag catcaaggca ctctgcccgt cgggaaaagc
    10981 gccgattgct tttgtacggc gtttaatctc acggttaagg cgctcaatcg cattattggt
    11041 ccgaatccgg gtccaatgct gcgtaggaaa atccatatag gtcaaggttt cttcgattcc
    11101 atcgtccacc ttcctggcag ctttggcaag cttcatggcc cggagcttct ccgctacctg
    11161 gattgctttt tcacgggcag cttccttgct ttcctgcgca tggatcgcct tgagcataag
    11221 agctaccgtt ttcatcttgt tccggggtgt acagaaaata tatttctgta aaaataaacg
    11281 gtacagcgct gatatctggc atccggaaag acttccggaa tggtttccag catgccgagg
    11341 ttcttatcac cgatgatcag gtgtacacca gtaaaccccc gttctttcag ccatacgaag
    11401 atagaacgcc agctttcacg atcctctttc atgccttccg cagcgccaag gatctcccgg
    11461 cagccatcct ggctgacgcc aatggcaacg agaacagaaa cgttttggat ctcgccgccc
    11521 cagctgcgtt tcaggtaaac accatctacg taaacatacg gatatttccc ggaaagcgga
    11581 cgggtactcc aggtctcgat atgctcataa gcctttttat tcaggttgct gatggttccg
    11641 ggggatactt tcgttcccca taaagtctcg gtgatatcct ccacacgccg gacagaaaca
    11701 ccggccagat acatctcgat aagagcttct tccacggaag attccctgcg gcgatatctt
    11761 tcgatgatgg ctgtctcgaa agggacccct ttcagtttag gaaccttccg ttcgacttcc
    11821 cctgcggtag tatggagatt tcgcttgtaa tagccggagc ggtatccctg gcggtcagag
    11881 gagcgctcat atttttcagc gttgactaat tcatcggctt ccttatcgag cagggcattt
    11941 aaggtttctt ccacactgct gcggacaaga tcctttaaat cgtgctttat taaatcttca
    12001 tttagctgta taatcttatc agacatggtt ctatagcctc ctttgatggg ttttgttgtg
    12061 gtgacttaat tctaccaaac ggctatagac gatgtccatt ttatgaaatt gattttgcga
    12121 aattaattat acgtcatctc ttgacatgcc tttttgcaac tgttatatat aaagcaaggg
    12181 tgaaaagctg atttttcaag cctttcaccc attcttatca tagaagaagc ttatttacag
    12241 acttttcttc atagtctcct tttctcaaaa gacttcaata ttagttacta caatttgaag
    12301 aaaaatagtt tgtcaacaga tccttttctt cataccctcg agaattctgg ctttgaaaaa
    12361 gtccgaattc tctgggattg cctcttcctt tcctataagg gttaaaaatc ggtattaact
    12421 gccccctata tattattata caagcgaaga acaaattaaa tttattgttt caactacttg
    12481 ccttattgac tcgttaaata aataaaaatg atctccgtca aatttatagt atcgacattg
    12541 ttttttggta taactattcc atagagaaat tttcttcaga atcacttcat cttccctact
    12601 accgtaaaat acagataaat cacattctaa aattggcaac tctgtagctt gaaacgtttc
    12661 aaggatttta tagtctgctc gtatgattgg tatgaaaata gatgctaaat cagtattatc
    12721 aaatacttct cttggtgtac ctcctagttt tagaacttcc cttcttagaa ctgatatgtc
    12781 tgcgtcatgg attgttttgc atcttgcttc gcactttggt ggtactacac tggataaaac
    12841 tatatgttta ggttcgttat attgttgact aataatcatc tgtgcaacac tatatacgat
    12901 acaacttccc atgctgtgac cgaataatat atatcttcca tttttaataa taggccttat
    12961 ttgttcaaat atatcaacta ttgcctcatc catcgtctgg tataatggtt cacccagtcg
    13021 ccttcctctc cctcttaact caatcggaat aagatttatg ttatcttcta aatatttctg
    13081 ccatttataa aaacatgatg agtttcctcc agcatggggt atacaaatta agtttatcct
    13141 attttccatc tctcttcggt tcctctctct accaaaacat taaatggtgc attttcagga
    13201 attacctccc ccagccctta caatagctgc acggacaagg caaagactgg gatcaatcaa
    13261 attacctttt atgtgatata gactcactgc tataggcagt tctgtacagc ctagaataaa
    13321 tgcctgctcc ccctctagtg actgtttgat aattaaattc tgaaatgcag ttccatcata
    13381 ctcataattt ccttccttat ataccattat aaattacatc tgtaacgatt ctctgttctt
    13441 catcatccga tacacgtaac tttaaattgc cttcccatat ccacctcccc tttcaaaata
    13501 gacacatctc ataaatctta actacatctt ctaattttag tggttcatag gcaaatgcta
    13561 acattccatt tgtaaccgct ctcttagcca taatttcaaa cttttcatca ttgattccaa
    13621 cttccggtaa tgaagcaggt agcctcaatt tcctaaagaa ttcagcagtc atattgatag
    13681 cgttcctagc catttcatat tcgtcacctt ccgatatgtc aaatacattt cttgcatatt
    13741 cagcaaactt tgctactgtt gtgtcattaa gcacgtattc catccacttt ggtagcagaa
    13801 tcgccatgcc tacaccatgg gtaatgtcat aacaggcact caattcatgc tctaacggat
    13861 gacaagacca cgctgttgcc tttcctgcac caagaatacc attcaatcca agagaactag
    13921 cccataacaa gttcgccctt gcttcgtaat tatcactttg ctcaattgca atcgggccat
    13981 atttaataca tgctttgagc ataatttctg ccatatggtt ttgtatgaac gtatcttcat
    14041 cttttgtaaa atagctttct attatatgtg acatagtatc tgcaactcct gctgctgtta
    14101 attctgcagg tactgtgtac gtatatactg gatcaagaat agaaactttt ggctgcatgt
    14161 aaaccgaggt tgctcctaat ttttcctcta tctcttcatt tgtaataaca gcacttccat
    14221 tcatttcgga gcctgtacca gcacaggtaa caactgtaat gataggcaat gcctttttga
    14281 tttcaccagg gcaaagcact agatcccatg aatcatcatc atagtaatat ccagctgcta
    14341 tcagttttgc agcatcgata acacttccac cacctacagc tagtattact tgcacattat
    14401 tctttcttgc taatctaact ccttttcgta catcttcaat ccttgggttg ggggttaccc
    14461 ccgctaattc tgaaacatcg tattctgaca gcagttccat caagatctga tacacttcat
    14521 ttttcttaat gcttccccca ccatatacga gcagaatatt gctcccgtat gtacttaact
    14581 cttttggaag attcttaacc attccctttc caaataatac tttcgtcgaa atattcaaag
    14641 taaagtttct catctattcc tcctaagttt tattcttgtc tcatacttta cgataaaaat
    14701 cttctgagtt tgttggatat tcattgatat atggtacgcc aatattccat gaacctttcc
    14761 tttcgtcatg aatattaatg gagtaccatt tgtttatatt agcagatcca aaacaaacct
    14821 taatctgcat ggtagttaaa tctgctacta tcgaatacaa cgttcctaat ccatctttat
    14881 agtagtggca acatacacct tcaggcattt ttttttgtaa aatgtcgcga attacacttt
    14941 catttacgtt tggaatatgt tcttttatgg actggtttgc tgcttgaaat ctcataaccg
    15001 actgattcat tcggtttaca ttaaacgact ccatctctgg cagattataa tgattggttg
    15061 aaaccacata gtctactacc tgtcttgtaa ataacgatct gatatttccc agaccggagc
    15121 tttccgctaa aactgcattg ccttgtttat ccgctattat aaaattcgta tttgctgaaa
    15181 gtggcatatg ctttaacaga taaactgctt catcggttgt acgacaattt tctatcatac
    15241 atcgtattgc cgtccaaaag cgaagtccac ttaattctgt atctgtacca ggtgttgctg
    15301 cagaaatggt gatagacagt ccatgctcat ttatcccttc atacctccca aataggtata
    15361 ctgaaaatcc aatatgagct ggttttccgt taatcttgca acacgtgaac cttgtatcat
    15421 catctaaaga atactcatag cttcttccta ctaaaacatg atgattttct gtcacttttg
    15481 gtaatgctac catatggcag catcccccct ttactgcata taagttagta tgaaaaataa
    15541 ctccatctga tgaaacatgt aatgcatctg aaaagccttc aatttcttca tttaatcctg
    15601 gacaaaattc atcatataat gctctgattt cttttatttt gtttttcgtc aatgttgctt
    15661 tatcgcaata gaatggcttg gtgtagtact gcatatcgga tggatatttc tttaggtatt
    15721 cccctctttg ccttccaact tcgtagctat cgccttccaa aaatacatat tcataattga
    15781 gtgttcctct ttccataaat gcaatcaata tctccttctt aattttatac atacattagt
    15841 aagcgtcgaa tcaatgcttc atccatctct tgggcattct gtaaactcaa ttttatcctg
    15901 tctaacatac gattattctg tctaaatata tactttaaat tcatattcac tactctcttc
    15961 gctagttcgt aaagtctatt agcaattcca ctcacttctt tatattgttc ctgattcaga
    16021 aaaacctttt ctagaaagta atcgacacgc attttcatta tctctttatg ttcacagtat
    16081 aagaacataa tacgtacatc taacaactaa gtaatctact aattctgaag agtaatttag
    16141 ctgtatatag tttgtaaaaa acaagtcttt aaaagagttc tttcgtggct ctaggtaata
    16201 cccaatataa taagataaca tgtggattac gaaaggaata cgtatcacat cgttccattc
    16261 aattccatca actgaacagc atcattcaat tccttcctca agcacctcaa tcctcagcca
    16321 cttactatta ggcaccacat cataaaatgc ttcttacttt ggattcgttc caacacatgc
    16381 acagactaac accgtaccca ttggtaaaaa agcaaattat aggtatactc ttgcttcatc
    16441 taaactatcc atcgtgataa taataccttt ctgcgtcaga tgatcatttt ccttaaaatc
    16501 ttcaacacag acagtaaaac ttcctgtccc ggaaacggtc tgatacaaga ctacgctctt
    16561 cttatcttcg ttttccggct taattagtgc taagcttaat aaatcatctt ccttccactg
    16621 tttcagttta cagtagtttc cagaacgtga tactgagaac tgttagcacc tttaaaattc
    16681 caaatccccc ttataattgc atcttgtcca tcctttaaat ggcttgcagt cacaattgcc
    16741 atgaaatcgg catcatgtgt atatgattta agaataagtc tcattaatat ccaatatcat
    16801 ccttataacc tcctatatag ccgcggaata ttcgcaatac ttttaagcac tttttcatgt
    16861 ctactgcatt aggatttacc acatctaatc gatttgacat accacatatc cttcttctgt
    16921 tgcttcctag tgtaacccat ctgttgtttg gacatctgca aagccgttct ggaatatgat
    16981 cgcagaacca ttggaacagt tccttatcct ttccttcaag atagctagcc atggccgata
    17041 tattctcatg tttattaaag taaatgcata ctaaataact gctcctgtct gcatagaacc
    17101 ccaagcagct ttttcctttc actgtaaact ccaccttcca ttggaatcct gatgtgatat
    17161 ttctaagagg ttttactttc accttgtatt tctcatcttg cagtgcattg ataagacgat
    17221 taatgttccc gttcatttct tctgtaagag tttccataat gtcttctatc tctggtatag
    17281 gttgacgtat tctcttataa tccagacgca gataattcat atatttatac ttactgtctg
    17341 gtgcattaca cagttccact aatccaataa acattttagg atatttttcg catgtcataa
    17401 tgtagctatt cccacattcc cgtagtccca atcctgtatt aagaagaatc attatcctct
    17461 ctttctggtc ttttcgaatc ttagccatcg atgtatttgc acacgcaatt cgataactat
    17521 cttttgaaat ctccagacta aaatcttcca ttcttatcct agaaacacaa ccaagttcat
    17581 aaagaaattt aaaataaaag ctgattgatt gctgaaattg attacgcaaa ctggactctt
    17641 tggaatcctg aaaatgctgc ttttctacaa ggaattttcc cttcttctct tttcgctcat
    17701 tactagccat atattcatcg tacttttcag aatcaatttt atatacttta gggttcttgt
    17761 ataggttaac ataaagtcct gtaatatact gatagaactg taactcccct tctttataat
    17821 cctgtgacga tatatctttc gtatccgctg gaataactga ttgaaaacct gctaacatct
    17881 caactgcatg acgtatggag tactgtgcag aactttcatt agcacatttc tcctgttcga
    17941 taaaaagcat atcacccctc cttagttaac tgttcagcaa acatactttt acagctgttc
    18001 ttgaatataa tcaacaatat ccttcgctgt gaaaaatttc atgatatagt catcatctat
    18061 tataacagaa aattcatctt caaagctcgt catgatagaa ataaactcca acgagttgat
    18121 tcctgctatc ccttttaagt ctgtttgcag tgtaatattg atatcttcat ctttatcttt
    18181 tacaatatcg cgaattatcg ataagactct ttcttctatt ttacttcgtt ccatcataaa
    18241 ctcctcctgt ttttcaatat attcttaata tctttttatt tttttggtag acgttttctc
    18301 aaattcctta tctctaaatt caatacttgt tatctgcatg taggaaggca atgttcgatt
    18361 caattcagta acctgctcat ctacatactt cttaatatcc gatatttgat gttcctgtac
    18421 aacctgctca tcgcagaaaa ttgttgccag tatatgttct gaaccattga tttttctact
    18481 gcttacaaca acttccttaa taacgtcaat tttattcagt ctagattcta aattctctgg
    18541 tgatacattt tttccattgg caagtatgat cagatttttc actcttcctg ttataaacag
    18601 gtaattatct tcatctatat agccaatatc acccgttttg aaccactcac ctttcataac
    18661 ttctcgtgtc ccctgcgtat cattatagta tcctagcatg atattatcgc ctttggccat
    18721 gatctctcct acttcatgcc cattgtaaca gccatagttt tggctgttat ccacttttac
    18781 ttgacagcaa gacacaacag gacctacgga atacctcttt ttacagcaat ctggattcgc
    18841 tgacagtaat ggtgaacatt ccgtaattcc atatccatgc actacattga ttcctatgtt
    18901 atcgaagaaa tcaatataat cctgatccaa attggaacct ccacatacga ttaactttaa
    18961 gttaccacca aactgctctc ggacatttgc aaatagtttc ttatagcagg aaaatcccat
    19021 ttttcttaga atgcttgata ctttaatcat tacttcaaac aatttttctt ttttttggtc
    19081 cttgactgct aatataatat tctgatacat ctgttcgaca accatcggca cagaaaatag
    19141 aacagaaggt ttcatcaatt ttaagttgct gcttagatac tttaaactgt catttaagga
    19201 aactgatgcg ccgaaataga gcatcagaag tatgtcacat gtcatttcat aggtatgata
    19261 cagcggtaaa atggataatg aggaatcctt ttcatctaat cctagaatcc tcttagcact
    19321 cataacatct gtaataatgt ttttatggct taacataaca cctttcgatt ttcccgtagt
    19381 tccagatgta aaaacaatta cagcaagtag ctctgggtct atctcctctt ctgtaccaat
    19441 acattgtacc tccttacgta gcttatccat actaagaaaa tcttcttttc cttctctgcg
    19501 ttccctactt tcattgatta taatattaat agtattggaa tcagacacaa gttcttggac
    19561 attttttaca tacctttctt ctcctaaaat acaatctaca tcagctcgta tcatcagttc
    19621 tgcaagctcc gcatcattaa gttgtgtgtc taaaggaact gcaactaatc ctccatagac
    19681 aatccctaag taggatacaa tccagtcata agaggttctt cctagaattg ctacatgccc
    19741 cgtttgtaaa tcaaagtttt ttaatacttt tgctgttttc tgcacatcac aaagtaactc
    19801 tttatacgtc ttttcaataa cctcattttt ctctttatat ctgattgcga cattatctga
    19861 atactgatat cctgtatagg taaccaattc ctttatcgaa tgtagtttta tcccccaatc
    19921 ataaaatgga ttactatatg tttttctcat ccttaattct cctttccata tcttttatgc
    19981 tgcagttaag taattccact ttattcaaaa atactatcta attcctgcgt agatatattt
    20041 actgtattaa agtccatcga agtaaaacag tatggatttt cctctcttaa aaatgtggtt
    20101 atctgttcta tatgattagg tattttctgg cagatttcct gcattttttg ctctgagcaa
    20161 aggctgtagc tatagtaaat ggtaatctgc aatttagaat cgataataat cgcgtttatc
    20221 tccagctggt tttccatata attattcata cttacgtcat cccctgtgtc atatgaagca
    20281 tagcaaaaca attcacgttt tagcacagag ctgtaatttc ctaaataatt gagctttata
    20341 attggctgta ttttcttccg gttttttgca taccaaccag taaatactgg gtcaacgcta
    20401 agctgttttg ctttttgcat ttcttccttt atagtcctta gcctttcttt ctcatctcta
    20461 tccaaattgg taatatgaat tggtataata cttgtaaacc agccaatcgt tcttgacaga
    20521 tccaattcct ggtactccgt atttcttcca tgccactccg tatctattaa gaaatcctgt
    20581 ccaagcaacg gttcaagtgc tgtcaaaaca gcatctgcaa gcacatacaa ttcacttatt
    20641 gttttatttt ttcctatctc ttctatgaat ttttctgtag tctcttttga aagcatacac
    20701 tctatcttgc cattctttag ataactttca tccacttttg tatttctttt ataaaatttc
    20761 ttgaattctt cgattgcggt taaatcatac ttttgagtat tgagttcttc tctttttaca
    20821 tactctgacc actttctaaa ggatgaggtt tttaatggaa gctttaactg ctgcccattg
    20881 ttcttctgta aaagcagact ttccaaatcc tcaagcagaa ttccccatga cagtccatca
    20941 atgataagat gatgcatgac aataagtaag agattcttat ccttagaaaa tcgaatgaaa
    21001 ctaacacgaa acagataatt atcttcaatg aaaatactag atttttcata gattccgatt
    21061 tttcttactg tttcctcttt ttcattgtct ggcttatcta aaaggtcgta ataaatgatc
    21121 ttgaattctt tgcctatgct ttgatatttg agcttttggg actcccgatc cagatgcatt
    21181 cttaagatat cgtgatgttt tattagcatt tggaatacat tctccagatc tgcaacacct
    21241 acacgttggt ctaattctaa caaaaggctc tgatggtagt agttcctgtc tggatgattc
    21301 ctatcaaaaa actgtgcaat gataggggtc ggttctatcc aatccgttat ctcctcttct
    21361 ttatctggta ctgccttcgt tatatatcta accatatcag atatgattgg actaaacagg
    21421 atattagatg ccttcagatg aaacccatac tctaacattt gggaagatat cctaattgcc
    21481 tgaatagaat ccccacccaa ctgataaaaa tcgctttgca tctctatatg ttcattaggg
    21541 aaaactgagt gcaatacttc gattaatgtt ttgcatttct catcgaggta atctgtgcta
    21601 ctctcatttt tctccgccgt ttcctcaatc tctggcaaag ccgatatatt tagtttacga
    21661 tttgttgtaa caggaatttc gtttagttca tagtaaagat gtggaaccat ataacctggt
    21721 aattctcctg tcagatattc tacaagctct tgcttcgtaa ccgattctcg ttttacataa
    21781 tagcagcaaa gatattcttt tccactagcg tttttcttat gaataacaac tgcgtccttg
    21841 atctgcctca tcttctgtaa acagtttttg atttcatcca gctcaatacg gtaaccgtgc
    21901 agcttaatct gctgatctgc tcttccacag tattcaatac aatctggggc aatgaactta
    21961 gcaaggtctc ctgtggcata cattctttct cctttggtaa aaggactttt aatgaacttc
    22021 tccttggtta attctggttt atttaaatat cctcttgata atcctggact ggagataaac
    22081 atttcgccta ttccgtttaa tggcattggc ttcttagatg gatctaaaat aaaaactttc
    22141 acattatccg ctggcttgcc tactggtact gcaaaccctt tatctttctc cttgtcatac
    22201 tggtatatca tgcaaccaac aactgcttca cttggaccat attcattata tatctcaatc
    22261 ttatgactaa atttctctgt aatagtctta cataactctg cggtcaattg ctctccacca
    22321 actataatcc gctcaatctt tgactttgag cagtccatat caaccaataa cgacaaatgt
    22381 gttggcgtca tcttaataat acttaccaga ttatccagaa taattcgatt aagaacatac
    22441 acttcctgat cgtcgcgata aactaccacc ttatttccac taattagggg cgtaaaaata
    22501 gacgtaatcg ttaagtcaaa ggatagggaa gtaaagaaag ggaaagccat ctcatctccc
    22561 ctgacataca ccttatttgc ccagtaaata tagttaacaa ggcctttatg ttcaatcata
    22621 actccttttg gctcacctgt tgtacccgaa gtatatagga tatatgctaa atcacctggt
    22681 tctggtctta tttgattttg ctggctttct tccttatcta actctgaaag ttgcatttga
    22741 caagattgat aataaagtac ctcaactccg tacttctcta tctgctcttt ttccccatca
    22801 cagatgatga tatgtaaaga tgcatccttt atcatgaact gaatacgaga actgggataa
    22861 cttatatcaa taggaacaaa tgtacaattc gctttcatga tacctagtat gaaaatcagt
    22921 gtttcaattg aatgcttggt cattaatcct atatttcttc tttcatttcc acatcttttt
    22981 cttaattccg aagctataaa atctgacttt ctattcagtt cttcatacgt taacagcttt
    23041 gttccatcct ctacggcaat atgatttggt gtcaacctaa cctgctgctc aaacaaatca
    23101 attattgttt ccgtagaagg atatctagag gaagtattgt taaaatcaca taccaacatc
    23161 ttatattcct cttctgacaa catagttatg tcacacacta gtatatccct tttctctgca
    23221 actgctgata tgatatttcg atactgggag aagaattgta caatatcttc ttcttgataa
    23281 actgaagttt tatagtccac atcaatctct aattgatttc catcagccca atctctgacg
    23341 attagttgta agacataatc ctgctcacca ttataaaact cttttgcaac tgcctccatt
    23401 ccggctatct cagttttcaa cgtcacatta taataattaa aacagttttc ataaagtcca
    23461 tcttgtccct gctctcttaa ttttaactct tttaccagtc tattatatga aaaacgatgg
    23521 ttcttaaagc atatcataag ttccttctgc aacctaccta ccatttgcat gaaggattct
    23581 cccatatcca cgtggaaacg gaacggaagg gaacttacga acatgcctac tgtatgccta
    23641 ctcatcgcca tatttcttcc tgaaaacgga atacctacaa caatatcatt tgattgaaga
    23701 cttttactta gatagattat atatgctgcc aaaagtactg cattcagggt aaaatgagta
    23761 tccttagcat agtttcgaat tctactcgta tcttcctcac tccatatcca ttcttttctc
    23821 ttaccctgat tttgcataga gaatgttttt ctaattatcg gtaaatctgt aagcttattt
    23881 acccagtatt ccctatactt ttcatattgt ttagattgta aatactcctt ttccttttca
    23941 atataggtta cataatcata ctcagactcc tcgtccgttc cttgcttttc ttctccttta
    24001 accagttttt catactcctc actgatttca tctgttatca gctggaacga ccatgcatct
    24061 gaaattacgt gatgcagttt tacaagatag ccatagagat attcctcctt tttaaaggta
    24121 atgaactgat acaagaatcc attctctaac ggaaatgcag ttctcgcctg ttgctcaatc
    24181 cattcaagga aatctttctc atccgctttc ttctcgcaaa aatcaatatg ttcgatttcc
    24241 ttttttgagt ctgtagtata gtattgaaaa tactcatccg ccttcttcac aatatgcgtc
    24301 tgaaaaacct tatttttttg aatgacatga ttgatgcttg tctgtagctt ttctatctca
    24361 acagctccct ttatcaacat gtaaccacct atcgtaaaca tggacgattc tggattaagc
    24421 atttgtgtaa cccatattct ttgctgagct tcactcaatg gatataattc tttctctatc
    24481 atctgctcct ccatttttct acaatcaaaa atatgttcta gctctctact atctttccac
    24541 aatctaattt aataatctga tctgcagtat taaagtagtt atcatcatga gtgattacaa
    24601 taacgccttt tcctttcttt ttcagcatag gtaaaagctg catataaaaa taatctcgaa
    24661 ataccggatc ctgctccgca gcccactcat cgaaaatcat cattggctta tcatcaagac
    24721 agcttatcac aaatgccagc ctctttttct gtcctgttga aagggataag gattcaaatg
    24781 ctccattatc ctttatatgt actttatcct ctatcttcaa taattctaga taagatgcaa
    24841 cttcctcttt tctttcttga taaggaatac catataactt ttgaaataga tgaaaatcgg
    24901 aatacaccgc agtaaaacat cctagtaatg taagctgttc cacagatttc ccatttacta
    24961 gtatctcgcc atcttcttta caatataaac cagatactaa ttttccaagt gtcgatttac
    25021 cacttccgtt tcctccgatg ataaatgtaa tctgtcctgt ctgaaactct gcattgattg
    25081 gtcctagcat aaattttctg tcatctttaa cttcgtcctt gataatgtag tgatatataa
    25141 catctttcag ctgaatagtt aatttcttat ctggttctat tgctggccgt tccatcactt
    25201 cttgtgattc aacagaagat tgttctaatt cttctaacag tttattaatt ctcttcatat
    25261 ttacaccaat ctgggcatac tttgagattg ctgttgccaa agcttcgaaa ggtcctatca
    25321 gataaaatac aataaacaga ttttctctta atgtattaac gctgatacct ttaataagta
    25381 atggaaatat aaacacaacg accccaaata ctaggttata cataagaaca ttgtacatat
    25441 taaagtttaa taactttaag gaagctgctt tactaaagtc agctgacttt cttgtatact
    25501 gttccatttc ctgtttgaaa tcctttttcc gaaaacagtt gaagcataat tccttaaatc
    25561 catacactaa atctcgcatc tgcccaaaga aggtttcctg aatgtctctg ttcttttccc
    25621 agtattttgt tgcaatccta ttggtaataa tactaattag tccattaaga agtactatag
    25681 cagtcgatgc taagaacgca tacgtgcttt tcaccgtcag gtaaaggaga caaaatacta
    25741 tggtaagcat atttgagact agatttacaa ccacattagg catctctgaa acggcacttg
    25801 tatcattatt taatccagaa taaattctct cctgccctaa actttcaatc ttctggtatg
    25861 gtgcttgtaa tatcttttca atcatttgaa ttctcttgtt atagattaac tcattagtta
    25921 tgtaaatcat ttttccctgt aggagcttaa tggaatatac aaatactaca atagaaaaga
    25981 taaaatatag tagcaattcc tttgaatact gaagattcct attaaatgtt tcattaattg
    26041 taaatataat caatgcactt gcaacaccat ttacaacact tattgggatt aatgccatat
    26101 agttcttttc tccatcttta gtgaagttaa aggtaagcga aatatatagc ataaaaacta
    26161 caatcgctat atatactaag atgcaacccc aaattactgt ttttgatgcc catactccca
    26221 ctgcactcca tggcagacgc tcaaagagaa tcttcggtaa attataagta caaagtcctg
    26281 taaagattag cagaggaatt acaaaaaata tactggcaag cttcatatcc tttgccttta
    26341 catgaatcct tttctttttg aaaatatcta tcaatgcttt taataagaca actgcataca
    26401 gcaaaattac tacaatactt actataatga taatagagaa aaacatatca cttgatttat
    26461 aaaagtctgc tttgtactta gcgacacttt cgccattgta tattttaata atgctatctg
    26521 caatatactc tgctgcattt gaatcaatat tggtcaatat acagacccca aactgatctt
    26581 tcccctgcat ctcaagcatg gaagaaaagg taggatttga cccaccatgt tttatgatat
    26641 ctccattcat atctatcagc cagcctgatc cgtaaaactt atccccttct gctactacct
    26701 ttgtatttcc ctggtgagac ttcataatta attgagtaag ttcctctggg atctctacta
    26761 ttcccatttg aatctgcatc catcttgcca tatcctgtat acttgatacg atatatcctg
    26821 cagcagtatt tccacggtat gctggtggat tagaagctac ttcccttaag aactgaaact
    26881 tatatccttg tgctattctg tcttccactt cctcatcata gcgatacatg tgagtgtcag
    26941 acagcccaag cttatcaagg atctcctgct ccataaacgt ttcatataat tcacctgtaa
    27001 ccgactgaat gatatatgct agaatatcgt agttcacagt tgcatactga tacttttctc
    27061 ctgggtaaaa atcaagtttc actccattta ccatcttaac tgttttctca agggaatctt
    27121 ctgcagttcc ttctggaata taaccaattg tctgaaatgg gattccactt gtatgatata
    27181 gcagattggc aattgtcatg tcgttatcga gattcgtatc accgtcataa ctaaatgaca
    27241 accaaggaat atattctttt actggatcat caatggataa ttttccttcc tgttcaagaa
    27301 ggaggattcc taaacccgta aaagccttac tcatggaccc aagttcaaat aacgtatcct
    27361 cccctatttg ttcctgcatt tctcgatcct cataaccata cgtacggtag ataacttcat
    27421 cacctcgtac taaagctaaa gaagcacccg gcacttttgc tttccgcaaa gtttttttca
    27481 ctaaatcgtc aaccttttgg ataaattcct tatccacaga agtagaagtc gcagtcttag
    27541 atgtctcatc cgtcacctga tctgcatata ccaaactacg acagttcatg aacagaagaa
    27601 tggttatgac agcacacaca atgaaactcc ttattttctt catttattat ttacttacct
    27661 tcctaatcat tttgtattag cttttctaca taattaacta tttccataac tgtctcaaat
    27721 ttttcataat ctaattgatc atctgaaaat tcaaatccga actcatcttc aagtgcaact
    27781 acaatacgaa gatagtaata ggagtttgct cccaaatcct gtagttttgc ttccagatta
    27841 atgttttctg gctgtatttc cagtgtttgt gcaatcactt ttttaaatct ctcacgtata
    27901 tcattaacca tatgcctttc acctccttac acccattgac ttatgacaga ctggctatta
    27961 gattttgtgt aaatgacttc tcaacctcac aaagttcttt taacttaacg gtagtagtgc
    28021 ttagcgaatc ctttcgatat cggcctgtca gactatattt ttcaataata ttcttggcat
    28081 atctccaacc acggactagc tcttcaagtg tttttctatc aataaaatcc tctgggaaga
    28141 ttctagtcag gcgaaacaat gcggctgtct gtatttttaa tatgttacca aaagaataca
    28201 aataaccact tgaagctttt ttaaaagtct cctcatcttg tattaccttg tcaaagtttt
    28261 caataaactt tgataaaata tcgaatcctt gcattttctc gttctgatgc ttcaaaaggt
    28321 tccgtttgat aatttccaca tattcagttt tactgctttc ttttactttc ttagacgcta
    28381 actggatatc catataagat gggtattctt tatcgataat aaaattctct ttgataccta
    28441 cataggcatc tataatttca caatagttta ttttcctttc ggagaaatcc agcgtatttt
    28501 tatcactctg atcaagcacg tacaccgctt cattcttatc gtcgtatcca tatacaagca
    28561 gggtatgagg ccaatgctcc ttgttataag tatcttctct tgttgaaata aaataacaat
    28621 ccactctgat aattacaagt tttttctccg agattgctcc cttaatgttg gtaataatat
    28681 cattgctatg tacaatacga tttatcttta accctgattt acttaggaca ttaagcattt
    28741 tctctgataa gatatattct gcatcaatat tctgagaatc gtcctgcgtt gtatacacaa
    28801 acatgtcatt agctagaata cttctaatat ccttttggta atactgaaat actggaaaca
    28861 gggcattata gaaacaatcc ttatagatta agtcattaaa tggtttaatc ccctcgatgt
    28921 actgataact ctcatactgc acctccaaat ccgtcctctt gttttgctct gctataaatt
    28981 cccgtatact atttctgaat atctcgtcaa acagcttcaa attttcgatc tttgtaagtg
    29041 attctatata atttaagtta atacgaagtt tattttctat tatgatgctg ttaatatcaa
    29101 acaaaaaatc aactggataa tcaggatcta cggtataccc aaaatcaaag ttagaaattg
    29161 acataaactc actgtttaga ttctgatcga attctcccag ataattaaaa cgaatgtctg
    29221 ctgcaatatc taatgattct cctagcccat ctttcgataa atattttaag acaccataac
    29281 tcagtccacc gcttggaact gcagataaag tttctgctat cttttcaata taggaattga
    29341 tattatcctc tgttatatcg ataagaacag gataaactga agtgaaccag cctacggttc
    29401 tagtaatgtt tagattttcg ctaacatctc ctcttccatg cccttccatt tctaccacca
    29461 aatgttcctt atgcagaagc tttcgtaatg ccatgacaac acagccaagc ataatatgtt
    29521 ccatactaac aaactgctcg cttgctttta aacaaacctg ctgtgtctct tcctctgata
    29581 aaacaatggc aaagtctttt cttgttgtgg tcaagcattt ttgtaacact tatggctaat
    29641 aaaatcggtg gattgcagtt tggaatctat cggaactgt
//
