LOCUS       NZ_JADNBM010000009     21652 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Sellimonas intestinalis strain 1001217B_150727_G3
            NODE_9_length_141009_cov_57.6406, whole genome shotgun sequence.
ACCESSION   NZ_JADNBM010000009
VERSION     NZ_JADNBM010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Sellimonas intestinalis
  ORGANISM  Sellimonas intestinalis
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Sellimonas.
REFERENCE   1  (bases 1 to 141009)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Quantification of discrete gut bacterial strains following fecal
            transplantation for recurrent Clostridioides difficile infection
            demonstrates long-term stable engraftment in non-relapsing
            recipients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 141009)
  AUTHORS   Aggarwala,V. and Faith,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.75x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 02:59:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,087
            CDSs (total)                      :: 3,015
            Genes (coding)                    :: 2,958
            CDSs (with protein)               :: 2,958
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 5, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4 (16S)
            tRNAs                             :: 60
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 20 of 57
            Pseudo Genes (incomplete)         :: 33 of 57
            Pseudo Genes (internal stop)      :: 13 of 57
            Pseudo Genes (multiple problems)  :: 7 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:35:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 82720
            Orig. end                         :: 104372
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADNBM010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21652
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21652
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21652
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11652](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11652)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            complement(89..1363)
                     /gene="hisS"
                     /locus_tag="I2A62_RS08500"
     CDS             complement(89..1363)
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015524641.1"
                     /locus_tag="I2A62_RS08500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_195243234.1"
                     /transl_table=11
                     /translation="MALKKKPVTGMNDMLPREMEIRDYVIQMIKDTYRTFGFSAIETPC
                     VEHIENLLSKQGGENEQLIFKILKRGAKLNLETAKTESDLVDGGLRYDLTLPLSRYYAN
                     HANELPSPFKALQVGNVWRADRPQRGRYRQFMQCDIDILGEPSNLAEIELILATSTLLG
                     KLDFRHFTIRINDRQILKAMAGYSGFAKESFDEVFIILDKMDKIGPEGVEMELKEAGYK
                     ENVVDTYLTLFKEVTNDLEGIHYLKEKLAGYLEPEVAEGLETIISTVEETKEADFAMRF
                     DPTLVRGMSYYTGTIFEISMDEFGGSVGGGGRYDKMIGKFTGQDTPACGFSIGFERIVL
                     LLLESGYQIPTKKEKKAYLIEKGMPSEGVTRILALAKEERAKGYQVLVSNMKKNKRFQK
                     DQLAQDGYTDVKECFVREFAPQGEE"
     gene            complement(1354..2820)
                     /gene="hemZ"
                     /locus_tag="I2A62_RS08505"
     CDS             complement(1354..2820)
                     /EC_number="1.3.98.3"
                     /GO_function="GO:0051989 - coproporphyrinogen dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008976439.1"
                     /locus_tag="I2A62_RS08505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="coproporphyrinogen dehydrogenase HemZ"
                     /protein_id="WP_195243253.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-22, bitscore: 73.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKLTCNDTLYTYDAYHLLKAFYPDEEIEQQVDEEQESQIRIESD
                     CDSCFCVTLAGEKTELLQMDRGEKKHLAVRSLYEKLCRATKKSLPWGSLTGVRPTKMLM
                     QKLEEGVPDDRILDWITKEHFVSGEKAKLGLDIAKREKRLLSRLDYENGYSLYIGIPFC
                     PTTCSYCSFTSYPISQYLEKTDAYLEALCKELSYIAAVSREKKLNTIYLGGGTPTSLRA
                     DQLDRLFTHLEKQFSYEHLLELTVEAGRPDSITREKLKVLKRHGIGRISVNPQTMQQKT
                     LDLVGRRHTVEDVITTFRVARELGFDNINMDLIAGLPGETPEDMEDTLTKVQELGPDSL
                     TVHALAIKRASRLRQEQRSGEGFTGHTASAGDLTAMIDAAYRCAGEMGLVPYYLYRQKN
                     MAGNFENVGYAEVDKAGIYNILIMEEKQSIVAAGAGASTKIVLPKAVEMPGSKKHKMTN
                     LIRIENVKQVDEYIARIDEMIERKGEWLWH"
     gene            complement(2829..3461)
                     /locus_tag="I2A62_RS08510"
     CDS             complement(2829..3461)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016293862.1"
                     /locus_tag="I2A62_RS08510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_053768795.1"
                     /transl_table=11
                     /translation="MKIETFVTGIIGTNTYVAYNETTKEAVLVDPAACTKKLMHFIEEE
                     GLSMKAVLLTHGHFDHIMGIDGFRKVYDVPVYVGEKEAGLITDAHWNQSDIYTKGYTFS
                     EAVYVQDGKILRLAGYDFQVFFTPGHTPGGVCYYVASEGILFSGDTLFHHSVGRTDFEG
                     GSMSDLVRGIEDKLLPLPDETKVLPGHMDATTIGEEKKYNPFLRRHV"
     gene            complement(3481..5799)
                     /locus_tag="I2A62_RS08515"
     CDS             complement(3481..5799)
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016439350.1"
                     /locus_tag="I2A62_RS08515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_024732960.1"
                     /transl_table=11
                     /translation="MAEKIRPEEVTTEVRQGLRIVDGHAVKEPEDYQDPDELYQYLIGH
                     IRKYHPSADVSMIEKAYELASKAHANQFRKSGEAYIIHPLWVGIILAQLEMDKETIAAG
                     ILHDVVEDTEETKEDIARDFGEDVALLVDGVTKLGQLSYSSDKLEMQAENLRKMFLAMA
                     KDIRVIIIKLADRLHNMRTLQFMKPEKQKEKARETMDIYSPIAQRLGISKVKTELDDLA
                     LKYLHPEVFYDLVQQINERKTEREEFVAQIVKEVSQHMENANIQAEVNGRVKHFFSIYK
                     KMVNQDKTVDQIYDLFAVRIIVNTVKDCYAALGVIHEMYTPVPGRFKDYIAMPKPNMYQ
                     SLHTTLMSTVGQPFEIQIRTKEMHKTAEYGIAAHWKYKESNDGKKNIKAQEEEKLNWLR
                     QILDWQKDMSDNREFLSLIKGDLDLFAEDVYCFTPNGDVKNLPNGSTPIDFAYAIHSAV
                     GNKMVGARVNGKLVKVDYKIQNGDRIEILTSQNSKGPSRDWLNIVKSTQAKNKINQWFK
                     KQFKEENIIRGKEMLVSYCKSKGLEQGNLLKPKYQQIVQQKYGFKDWDSVLAAIGHGGL
                     KEGQIVNRLADEYNKDHRQEITDEAVLEKVAEASKNVVHIAKSKSGIIVKGIDDMAVRF
                     SRCCNPLPGDEIVGFVTRGRGLTIHRTDCINVLHLTERERARLIPVEWEADADEASEGK
                     YFAEIKMYVEDKPGTLMEISRVFTETEIDIKTMNVRTSKKGVSTVEMGFVVRGKEEMGR
                     LIGKLRQIENVIDIERTTG"
     misc_feature    5883..5896
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            complement(5961..7724)
                     /gene="recJ"
                     /locus_tag="I2A62_RS08520"
     CDS             complement(5961..7724)
                     /GO_function="GO:0008297 - single-stranded DNA
                     exodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440042.1"
                     /locus_tag="I2A62_RS08520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="WP_195243235.1"
                     /transl_table=11
                     /translation="MKNWVLLRKGGNFTKIGERFHIHPRTAALIRNRDIIGEEAVDRYL
                     NGTIADLYDGMLMKDMDKAVDLLKEKLTEGQSIRIIGDYDIDGVNATYILLEGLTGLGA
                     RVDYDIPDRIRDGYGLNIDLIDRALDDDIDTIITCDNGIAAKNEIAYGKSMGMSIIVTD
                     HHEVPYEEKEDGTREFQIPPADAVVDIKREDCLYPYKGLCGAAVAYKLIEALYNVMGKD
                     PEDVDYLMENVAIATVGDVMDLRDENRIFVAQGLEMLKRTKNLGLRALMECTGVNKECL
                     SAYHIGFVIGPCINAGGRLDTAKRALELLCAGTQKEADLLAGDLKALNDSRKNLTEEAV
                     KEAVIQVETTGLKEEKVLVVYLPECHESIAGIVAGRLRERYYKPVYVLTRAEEGAKGSG
                     RSIEGYHMYDELCKCRNLLTRFGGHRLAAGLSLPEENIFFLRKALNDQTTLTERELTEK
                     IVIDMQLPLCEVTESFIKELSLLEPFGKGNTKPVFAQRKLSLLRGRLLGKHQNVLKLEV
                     MDEDHTIMEAVFFGEMESFFSCLSEKYGPDAREQLLSGRGQDLFMDVTYYPGVNEYMGK
                     KTLQITILDYR"
     misc_feature    7677..7691
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 20.95"
                     /tool="antismash"
     gene            complement(7801..9981)
                     /gene="secD"
                     /locus_tag="I2A62_RS08525"
     CDS             complement(7801..9981)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /gene_functions="transport (smcogs) SMCOG1049:
                     AcrB/AcrD/AcrF family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004605087.1"
                     /locus_tag="I2A62_RS08525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_195243236.1"
                     /transl_table=11
                     /translation="MKKSRGIAGLLGTILMIALLAYTVSFGWGGSHSGAMKNIKLGLDL
                     AGGVSITYQTKEKNPSDEDMRDTVYKLQKRVETYSTEASVYQEGDRRISISIPGVSDAN
                     EILEELGQPGTLEFQTSDGETVLTGSDIKTAEAKSGQDHTTGANEYMVELQLNKEGSKK
                     FAEATKENIGNQISIIYDGETISSPRVNEAITGGTAYIDGMATFEEAENLAASIRIGGL
                     SLELEELNSQVEGAQLGEEAISTSLYAGAVGLAVVILFMMIVYLLPGLASGLALLIYTG
                     LVLMLLNAFDITLSLPGIAGIILSIGMAVDANVIIFARVKEEISAGKSVRNALKGGFHK
                     ALSAIVDGNVTTLIAAAVLWFRGSGTVRGFAQTLALGIVISMFTALVITRMIVYSFYAV
                     GIRDEKFYAKKWKERKPVNFLSKKALCFAISLAVIVVGFGVMGYHQIKGNGMLNYSLEF
                     QGGTSTNVAFHEDYSISEIESEIVPVIEEATGDSEVQTQKVKESNQIIIRTKALSLQQR
                     EALNQALADKFEIKDSEITYSSISSTISAEMRQDAVIAVVISTICMLLYIWLRFKDIRF
                     ATSAVAALVHDVLVVLAFYAVSRITVGSTFIACMLTIVGYSINATIVIFDRIREELKVR
                     KKKESLAELVNRCITLTLTRSIYTSLTTFIMVFFLFLFGVASVREFALPLMAGIICGAY
                     SSVCITGALWYVMKTKVGKKKEAVKTETGKKK"
     gene            complement(10001..11416)
                     /gene="scfB"
                     /locus_tag="I2A62_RS08530"
     CDS             complement(10001..11416)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243476.1"
                     /locus_tag="I2A62_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_024732963.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 4.9e-30,
                     bitscore: 96.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.8e-78, bitscore:
                     257.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.6e-17, bitscore: 56.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 8.2e-15, bitscore: 48.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.6e-19, bitscore:
                     61.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYQNNGYNIVLDVNSGCVHVVDQMGYDVIAALNAIHPEQTAS
                     TIQTAKTREAIKAQFENTYEPEEIDTVLDDLAELTEAGQLFAPDTHEACIQDVMKRKTV
                     VKALCLHIAHDCNLACKYCFAEEGEYHGRRALMSFEVGKKALDFLIANSGSRRNLEVDF
                     FGGEPLMNWQVVKDLVAYGREQEKIHDKHFRFTVTTNGVLLNDEVQEFINQEMDNVVLS
                     LDGRREINDRMRPFRNGKGSYDLIVPKFQKLAKSRNQQKYYVRGTFTRQNLDFSEDVRH
                     FVDLGFQQMSIEPVVGDETDPYAIRKEDLPQIFEEYDKLASYMIQREKEGKGFNFFHFM
                     IDLEGGPCIAKRLSGCGSGTEYLAVTPWGDLYPCHQFVGDEDFLMGNVDDGITKPEIAD
                     EFRCCNVYSKEKCRNCFARFYCSGGCMANSYHFEGTLHDAYDIGCEMERKRVECAIMIK
                     AALADIGEESRQA"
     aSDomain        complement(11084..11416)
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I2A62_RS08530_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="1.10E-30"
                     /identifier="RREFam024.1"
                     /label="I2A62_RS08530"
                     /locus_tag="I2A62_RS08530"
                     /protein_end="111"
                     /protein_start="0"
                     /score="96.8"
                     /tool="antismash"
                     /translation="MIHQYQNNGYNIVLDVNSGCVHVVDQMGYDVIAALNAIHPEQTAS
                     TIQTAKTREAIKAQFENTYEPEEIDTVLDDLAELTEAGQLFAPDTHEACIQDVMKRKTV
                     VKALCLH"
     misc_feature    complement(11506..11522)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.35"
                     /tool="antismash"
     gene            complement(11509..11652)
                     /gene="scfA"
                     /locus_tag="I2A62_RS08535"
     CDS             complement(11509..11652)
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004605085.1"
                     /locus_tag="I2A62_RS08535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_008976445.1"
                     /sec_met_domain="TIGR03973 (E-value: 2.8e-27, bitscore:
                     87.4, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 2.4e-27, bitscore: 87.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHIKTLNTQTLNNTMKKGGCGECQTSCQSACKTSCTVGNQTCEQ
                     KK"
     gene            complement(11784..12155)
                     /locus_tag="I2A62_RS08540"
     CDS             complement(11784..12155)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006442054.1"
                     /locus_tag="I2A62_RS08540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04086 family membrane protein"
                     /protein_id="WP_024732964.1"
                     /transl_table=11
                     /translation="MRVKGQKSGVMRIFQALLVSYIITGILLLVLAVLLYKLNLDKGKV
                     TAGITGIYVVSAFAGGFLIGKLQKVRKFIWGLMLGILYFLLLVLVSFGVYHTLQGDVMQ
                     IVTTLVLCAAGGMLGGMLS"
     gene            complement(12214..12765)
                     /locus_tag="I2A62_RS08545"
     CDS             complement(12214..12765)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009262926.1"
                     /locus_tag="I2A62_RS08545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="stage V sporulation T C-terminal
                     domain-containing protein"
                     /protein_id="WP_024732965.1"
                     /transl_table=11
                     /translation="MKATGIVRRIDDLGRVVVPKEIRRTLGIREGTPLEIFTGKDGEVI
                     LKKYSPLGEIYTFAQNYAESLSQASGVLTCITDMEKVIAASGAGKKDVADQEISEEFVG
                     LLEERRMVQKGVREKGMVPLLKYKNLDYLESLVCPVLTGGDVIGAVVFLWQEEEKGASK
                     EICQKLAQCAATFLGSQMEA"
     misc_feature    12845..12863
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            12918..13364
                     /locus_tag="I2A62_RS08550"
     CDS             12918..13364
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005337759.1"
                     /locus_tag="I2A62_RS08550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GatB/YqeY domain-containing protein"
                     /protein_id="WP_024732966.1"
                     /transl_table=11
                     /translation="MSKIDDVRKEMVVAMKAGDKARKETLSSLLAALKNKAIDKREDLT
                     AEEEVQVVLKEIKQTKETLEMTPADRAEIIAECRARIAVLEEFAPKMMDEEEIKTVISS
                     VLSDLELTTPTAKDKGKIMKELMPKVKGKADGKLVNELVSTFFV"
     gene            complement(13400..14521)
                     /locus_tag="I2A62_RS08555"
     CDS             complement(13400..14521)
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008371871.1"
                     /locus_tag="I2A62_RS08555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-prolyl cis-trans isomerase"
                     /protein_id="WP_195243237.1"
                     /transl_table=11
                     /translation="MKKRLAVVLLTAVIAAGAMAGCGQETIKDSDVVATVGKTEIKGNI
                     ANFFARYQQAMYETYYSSMLGENMWTTKVDDDTTYEESAKETIMQSLEELYLLNEHVGD
                     YDVSLTEDEKKAIGEAADAFVEANGENVREVISGDKETVEEVLRLFTIQQKMRTEMLKD
                     VDRKVSDEEAAQKAMQYVAFTYSEESKSEDSESTSDTKEEAKTKADTFLDAVKGGTDFE
                     QAAKDQETSTLDLTFNSETTSPNEEVIAAADKLDAGQVTDVIETDSGYYVAKVTSTFDQ
                     TATDNKKQQIISERENDRYNEIVEGWKDDTKIKENKDVWKKIDFNEQGVAVKKAEDDSD
                     STDNSTSKDSTDEENTDDSENTDNTDNAEEAAE"
     gene            complement(14551..17925)
                     /gene="mfd"
                     /locus_tag="I2A62_RS08560"
     CDS             complement(14551..17925)
                     /GO_function="GO:0003690 - double-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="mfd"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427088.1"
                     /locus_tag="I2A62_RS08560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcription-repair coupling factor"
                     /protein_id="WP_195243238.1"
                     /transl_table=11
                     /translation="MKAFTAPLLELAEFDTIQKTKYREPGMIQIAGSTGSQKGHLAYAL
                     AREDRRVLYVVQDEEKAKEILEEYQFLDAGVFFYPAKDFLFYRADIRGKYLTQKRMEVI
                     RALREEEKVTVVTTIDALMDGVRPPSGINGQIFTLRVGDMSDLEELKVRLSKMGYDREI
                     QIEGPGQFAVRGGILDVYPLTEEMPVRIEFWDDEIDSIRTFDVETQRSVENREEITFYP
                     ASDTVSGKQGVSFLQYFQPEETLLFLDEPARLYERGLTIEEEVKEAQERREEAERTSKT
                     EEDEIRMFLVREIVGLLNSYHSIGFTALEGKLKEFHVRETYSILAKNVNPYNSSFEVLT
                     RDLKRLKRNGYRVILLSGSRTRARRLAEDLRDYDLNSFYDEDPNRLVKPGEIFVSYGHV
                     AVGYEYPMLKFTVISETDIFGKKKRKKRRKIYEGEKIQSFTDLKPGDYVVHENHGLGIY
                     QGIEKIEVDRIEKDYMKISYAGGGNLYIPATQMDLIQKYASADAKKPKLNRLGGQDWER
                     TKTRVRKAVQEIARDLVELYATRQEKDGYAYEPDTVWQKEFEEMFPFEETDDQLAAIED
                     TKKDMESHKIMDRLICGDVGFGKTEVAIRAAFKAVQENKQVAFLVPTTILAQQHYNTLV
                     QRMKDFPVRVDLMCRFRTPAQQKKTLEDLMKGQVDILVGTHRILSRDVTFKDLGLLVID
                     EEQRFGVQHKEKIKKLRENVDVLTLTATPIPRTLHMSLIGIRDMSVLEEAPMDRMPIQT
                     YVMEYQDEMVREAIVRELSRQGQVYYVYNKVKDIAEITARIQSLIPEANVAYAHGQMRE
                     HQLERIMYDFINGDIDVLVSTTIIETGLDISNVNTMIIHDADKLGLSQLYQLRGRVGRS
                     NRMAYAFLLYRRDRLLREVAEKRLAAIREFTDLGSGFKIAMRDLEIRGAGNLLGEAQHG
                     HMEAVGYDLYCKMLNEAVKGMKQGIDQDEVESFTTTIDLNVDAFIPASYIPDEYQKLDI
                     YKRIALISTEDEMDDMMEELIDRFGDIPKKVQKLILIARIKALAHSVYVTAIEQKGSTL
                     KITMYEKAKVQVQEIPKLLERRKGELLFKNDAPPYFLYEQKKRNRKEKDQDILEVVKNL
                     LNDIKTLIVKGKPDIIG"
     gene            complement(17945..18514)
                     /gene="pth"
                     /locus_tag="I2A62_RS08565"
     CDS             complement(17945..18514)
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="pth"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009262932.1"
                     /locus_tag="I2A62_RS08565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_195243239.1"
                     /transl_table=11
                     /translation="MFIIVGLGNPGLKYEGTRHNVGFDVIDKIAEEYHIAVDTRKHRAL
                     IGRGVIDGFRVILAKPQTFMNLSGESIRELVDYYKVDEETDLIVIYDDISLDVGQLRIR
                     KKGSAGGHNGIKSIISHLGHDAFLRIKIGVGEKPRGYDLADYVLGHFEGEDKEKMEEAY
                     EKAVQAVRMALHGDICEAMNQFNRKG"
     gene            18741..19172
                     /locus_tag="I2A62_RS08570"
     CDS             18741..19172
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004081323.1"
                     /locus_tag="I2A62_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_024732970.1"
                     /transl_table=11
                     /translation="MSSKTKIVVFHMKEIIYTAIFAALGILLILLLLFMFLPGHTKGKQ
                     TSKDYKPGIYTASMTLNNTPLEVEVSVDKNHINSIRFANLDESVETMYPLVQPAMEEIA
                     GQIIKSQSTDKIKAGEDDSYTSNLILDTIQKALKKAEAD"
     gene            complement(19192..19455)
                     /locus_tag="I2A62_RS08575"
     CDS             complement(19192..19455)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440037.1"
                     /locus_tag="I2A62_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glyoxalase"
                     /protein_id="WP_024732971.1"
                     /transl_table=11
                     /translation="MERFSEECLEVFLREQSQLFDEPVAETPEEAEAFLEDCMAVVLDS
                     LEEVRDYLDEYGADVDGMTLGEIEDASEVFALPGGQYLVVEG"
     gene            complement(19442..20158)
                     /locus_tag="I2A62_RS08580"
     CDS             complement(19442..20158)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008371878.1"
                     /locus_tag="I2A62_RS08580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_243240177.1"
                     /sec_met_domain="HAD_2 (E-value: 8.9e-40, bitscore: 129.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQENGVRKMYKACIFDLDGTLTDTLESITYSVNLTMERMGLPPI
                     TMEQCRRFVGNGARKLLECTLRACGDEEMSRMEEAMAVYGDVFAKYCTYHAKPYDGIKE
                     MLERLKKEGVFLAVLSNKPDGQTRDVVRTFFGDHFFDAVQGQKEGIPRKPDPAAVLSIL
                     ERAGITREECVYIGDSDVDMHTGNNAKVKTVGVSWGFRSKELLYETGAHVVIDHPEELI
                     SVVTVQKGKEETHGEI"
     gene            complement(20284..21060)
                     /gene="sigG"
                     /locus_tag="I2A62_RS08585"
     CDS             complement(20284..21060)
                     /codon_start=1
                     /gene="sigG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006442063.1"
                     /locus_tag="I2A62_RS08585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sporulation sigma factor SigG"
                     /protein_id="WP_024732973.1"
                     /transl_table=11
                     /translation="MALNKVEICGVNTSKLPLLKEEEKEELFARIKEGDEEAKEKYIKG
                     NLRLVLSVIKRFAGSSENPDDLFQIGCIGLIKAVNNFNTELDVRFSTYAVPMIIGEIRR
                     YMRDNNSIRVSRSLRDTAYKAIYAKENYVKKNLREPTVQEISEEIGISKEDIVFALDAI
                     QAPVSLNEPVYNDSGDALYVMDQISDKKNKEERWIEDLSLQAAMEHLNEREKYIIRLRF
                     FEGKTQMEVAKEVKISQAQVSRLEKNALRLMRQYLD"
ORIGIN
        1 tgtttccttt cgtaagctcg gcgcaccggt gcgttctttt caggcccttc attgattctg
       61 ccatatctct tcctccatct cttttgctct attcctcgcc ctgcggcgca aattcccgta
      121 caaaacactc tttcacatcg gtatatccgt cctgtgcaag ctggtctttc tggaatctct
      181 tatttttctt catattggaa accagtacct gatatccctt tgcccgctct tccttcgcaa
      241 gggctaaaat ccgggtcaca ccttcagaag gcatcccttt ttcaatcaga taggctttct
      301 tctctttctt tgtcggaatc tggtagccgc tctctaaaag cagaaggaca atgcgttcaa
      361 atccgatgga gaatccacag gccggggtat cctgtcccgt aaactttccg atcatcttat
      421 cgtaacgtcc gccgcctccc acagatccac cgaactcgtc catggaaatt tcaaaaatcg
      481 taccggtgta gtaggacatt ccccgaacaa gcgtcggatc gaagcgcatc gcaaagtccg
      541 cttccttcgt ctcctccacg gtggagataa tcgtctcaag cccctctgcc acttccggct
      601 ccagataccc ggcaagcttt tccttcaggt agtggattcc ctccagatcg ttcgtcactt
      661 ctttaaataa ggtcaggtag gtatctacga cgttctcctt atatcccgct tcttttaact
      721 ccatctccac cccttccgga ccgatcttat ccatcttgtc cagaatgatg aaaacctcat
      781 caaagctctc cttagcaaac ccgctgtaac cagccatagc ctttaaaatc tgtctgtcat
      841 taatacggat cgtaaaatgt ctgaaatcca gctttccgag caaagtgctg gtagcaagga
      901 tcagctcgat ctccgcaaga ttagacggct cgcccagaat atcgatatcg cactgcataa
      961 actggcggta tcttcctctc tgcgggcggt ctgctctcca gacatttcca acctggagcg
     1021 ccttaaatgg ggacggcagc tcgtttgcgt ggttagcata ataacgggac agtggtagtg
     1081 tcaaatcata gcgcagccct ccatctacca gatctgactc cgtctttgct gtctccagat
     1141 tcagctttgc cccacgcttt aagatcttaa agatcaactg ctcgttctct cctccctgtt
     1201 tactgagaag attttcgata tgctccacac atggagtctc aatcgcggaa aatccaaagg
     1261 tacggtatgt atccttaatc atctgtatca catagtcccg gatctccatc tcccgtggga
     1321 gcatgtcatt cattccggtg accggttttt tctttaatgc catagccatt ctccttttcg
     1381 ctctatcatc tcatcgatcc gggcgatgta ctcgtctacc tgcttcacat tttcaatgcg
     1441 gatcagattc gtcatcttgt gctttttgct acccggcatc tcgacggctt tggggaggac
     1501 aatcttcgta gaagcgcccg ctccggccgc cacaatggac tgcttttcct ccataattag
     1561 tatattgtaa attcccgctt tgtcaacctc tgcatatccg acattctcaa aattccccgc
     1621 catatttttc tgtcggtaca gataatacgg cacaagcccc atctcgcctg cacagcggta
     1681 agccgcgtca atcattgcgg taagatcccc ggcgcttgct gtatgcccgg taaatccctc
     1741 cccgcttctt tgctcctgcc gaagcctgga agcacgcttg atggcaagag catgtaccgt
     1801 caggctgtcc gggccaagtt cctggacctt tgtcagggtg tcttccatat cctccggcgt
     1861 ctccccagga agacctgcaa tcagatccat attgatattg tcaaatccaa gttctcttgc
     1921 cacacgaaat gtcgtaatca catcctccac tgtatgccgt cttccaacca gatccagtgt
     1981 cttttgctgc atcgtctgcg ggttgacgga aatccgccca atcccgtgcc ttttgagcac
     2041 tttaagcttc tccctcgtaa tactgtccgg acggcctgcc tccacggtaa gctccagaag
     2101 atgctcatag gaaaactgtt tttccagatg ggtgaaaagt ctgtccaact gatcagctct
     2161 aagagatgtt ggagtcccac cgccaaggta gatcgtattg agctttttct ccctggaaac
     2221 tgcagcaata taggacagtt ccttacagag ggcttccaga tacgcatctg tcttctccag
     2281 atactgactg atcgggtagg atgtaaaaga acaatacgaa caggtcgtcg gacagaatgg
     2341 tatcccaata tacaggctgt atccgttctc atagtctaac cgggaaagaa gccttttttc
     2401 ccgcttggca atgtcaagtc ctagtttggc tttctccccg gaaacaaagt gctcctttgt
     2461 gatccagtcc aaaatcctgt catccggtac tccctcttct aatttctgca tcagcatctt
     2521 agtcgggcgc acaccggtca gactccccca gggcaggctc tttttcgtgg ctctgcacag
     2581 cttttcataa agcgaacgga ctgccagatg ttttttctct cctctgtcca tctgcaaaag
     2641 ctctgttttc tcgccggcca gcgtgacgca aaaacaagaa tcacagtctg attcaattct
     2701 gatctgtgac tcttgctcct cgtctacctg ctgttcgatt tcttcgtccg gataaaaagc
     2761 tttcaacaga tgatacgcat cataagtata taaagtatca ttacatgtca gcttcattat
     2821 gatttctcct acacatgtct tctcagaaat ggattgtatt tcttctcttc accgatcgtc
     2881 gtagcatcca tatgtcccgg caggactttc gtctcatccg gcagcggcaa aagcttatcc
     2941 tcgatgcccc gcacaagatc cgacatactg ccgccctcaa aatccgtccg tccaaccgaa
     3001 tggtggaaca gtgtgtcgcc actgaacaaa atcccttccg acgcaacata atagcagact
     3061 ccccccggtg tatgtccagg tgtgaaaaac acctggaaat cgtatcccgc aagccgaaga
     3121 atcttcccgt cctgtacata gaccgcctca gaaaaagtat agcccttcgt atagatatcg
     3181 gactggttcc agtgggcgtc agtaatcaat cccgcttctt tctctcccac atagaccggc
     3241 acatcataaa ccttgcggaa accatcgatc cccataatat ggtcaaaatg gccgtgagtc
     3301 aggaggactg ccttcatgga aagtccctcc tcctcaataa agtgcatcaa cttctttgta
     3361 caggcggccg gatccacaag tacggcctcc tttgtagtct cattgtacgc aacatatgtg
     3421 tttgtgccga taatccctgt tacaaacgtc tctatcttca tttggtcctc tttccggcct
     3481 ctagcctgtt gtcctttcta tatcaatcac attttcaatc tgtctgagct tgccgatcag
     3541 acgtcccatc tcttctttgc ctcttacaac aaagcccatc tccacagtag aaacgccctt
     3601 cttacttgtg cggacattca tcgtcttaat atcgatctct gtttccgtaa agactctcga
     3661 gatctccatc agcgtcccgg gcttatcctc gacatacatc ttgatctccg caaaatactt
     3721 gccttcggaa gcctcatcag catctgcctc ccactccacc ggaatcagtc ttgcccgctc
     3781 cctctccgtc aggtgcagga cgttgataca gtccgtccga tggatcgtaa gccccctgcc
     3841 tctcgtcaca aaacccacaa tctcatctcc cggaagtgga ttacagcacc tggaaaaccg
     3901 taccgccatg tcgtcaatcc ctttgacgat gattccgctc ttggatttgg caatgtgaac
     3961 tacattcttt gatgcctccg ctactttttc cagaacagcc tcatccgtaa tctcctgtct
     4021 gtgatcttta ttgtactcat ccgcaaggcg gtttacaatc tggccttctt tgagtcctcc
     4081 atgtccgata gccgccagga cagaatccca gtccttaaaa ccatatttct gctgtacgat
     4141 ctgctgatat tttggcttca gcagattgcc ctgttccaat cctttggact tacagtagga
     4201 gaccagcatc tctttcccac gaatgatatt ttcttcctta aactgcttct taaaccattg
     4261 gttgatctta ttcttcgcct gggtgctctt gacaatattg agccagtccc ggcttggtcc
     4321 tttcgaattc tgggaggtca ggatctcgat tctgtctccg ttctggattt tataatccac
     4381 tttcacaagc tttccattca ctcttgcacc taccatctta ttacctaccg cactgtggat
     4441 ggcataggca aagtcaatcg gtgtcgagcc gtttggtaaa tttttaacgt cgccgtttgg
     4501 cgtgaagcaa tagacatctt cagcaaacag atccaggtct cccttgatta ggcttaaaaa
     4561 ctcccggtta tccgacatat ctttctgcca gtccagaatc tggcggagcc agttcagctt
     4621 ctcctcctcc tgcgccttga tattcttttt cccgtcgttg gactccttat acttccagtg
     4681 agccgcgata ccatactctg ctgtcttgtg catctctttc gtccggatct ggatctcaaa
     4741 cggctgtcct acagtactca tcagtgtggt gtgaagtgac tgatacatat tgggctttgg
     4801 catggcaatg tagtccttaa agcgtccagg taccggcgta tacatctcat ggatcactcc
     4861 cagggccgca taacaatcct taactgtatt cacgatgata cgcaccgcaa aaagatcgta
     4921 aatctgatcc acggtcttat cctggtttac catcttttta taaatgctga agaaatgctt
     4981 cacacggcca ttgacttctg cctgaatatt ggcgttctcc atatgctggg agacttcttt
     5041 tacaatctgt gccacaaact cttcccgctc agtctttctc tcgttgatct gctgcaccag
     5101 gtcgtaaaaa acctccgggt gcaaatattt caacgccaga tcatcaagct cggtcttgac
     5161 cttggaaata ccaagtctct gggcaatggg agagtagata tccattgtct cccttgcctt
     5221 ttccttttgt ttttccggtt tcataaactg gagtgtccgc atattatgaa gccggtccgc
     5281 cagcttgatg ataataaccc ggatatcctt tgccatagca aggaacatct tccttaaatt
     5341 ctccgcctgc atctccagct tatccgagga ataagaaagc tgtcctaact tggtaacgcc
     5401 atccaccaaa agggccacat cctccccgaa atctctggca atatcctcct tcgtctcttc
     5461 ggtatcctct accacgtcgt gcaggatgcc ggcagcgatt gtctccttat ccatctccaa
     5521 ctgtgcaagg ataattccaa cccacagggg gtgaatgata tatgcctccc cggattttct
     5581 gaactgattt gcatgtgcct tactcgccag ctcatacgct ttctctatca tcgaaacatc
     5641 tgccgatgga tgatatttac gaatatgccc gatcagatac tggtacagtt catccggatc
     5701 ttgataatct tcaggctctt tgaccgcatg accgtctaca atccgcagtc cctggcggac
     5761 ttccgtcgtc acttcttccg gtctgatttt ttctgccata tcaatcccct ccttttcctg
     5821 tttttctccc gctttactct caaatatcat gtcgtttttt ggaatatatt ttttagtata
     5881 tcattatttc aaaaaagtgt aaagcaaagc aagaatccat ttttcgtatg acctggccgt
     5941 atccttctct ttttacagta ttaccgataa tccaaaatgg taatctgcaa tgtctttttc
     6001 cccatatatt cattgacgcc cggataataa gtgacatcca tgaaaagatc ctgtcctctt
     6061 ccggaaagaa gctgctctct ggcgtctggg ccgtattttt ctgaaagaca ggagaaaaat
     6121 gactccatct ctccgaaaaa gacagcttcc ataatagtat gatcctcgtc catcacttcc
     6181 agcttgagaa cgttttgatg tttcccgagc agtctgcccc gcaaaaggga aagcttcctc
     6241 tgtgcaaaga ccggtttggt attccctttt ccaaacggtt ccagaagcga aagttccttg
     6301 ataaacgatt cagtcacctc acaaagcgga agctgcatat caatgactat cttctccgtc
     6361 agctcccgtt cggtcaatgt tgtctggtca ttgagtgctt ttcgcaaaaa gaaaatgttc
     6421 tcttccggca gagaaagtcc cgccgcaagc cggtgccccc cgaaacgggt gagaagattc
     6481 ctgcacttac acagttcgtc atacatatga tatccctcaa tggaacgacc ggaacctttt
     6541 gctccttcct cagcccttgt aaggacgtac accggcttat agtagcgctc cctcagacga
     6601 cctgccacaa tccccgcaat gctctcatga cattccggca gataaacgac cagcaccttt
     6661 tcttctttca gtccggttgt ctccacctgg atcacagctt ctttgaccgc ctcctcagtc
     6721 agatttttcc ggctgtcatt tagggctttt aagtctcccg ccagaagatc tgcctccttc
     6781 tgcgtaccgg cacacagaag ttccagcgcc cgttttgcgg tatcgagacg tccgcccgca
     6841 ttgatgcatg gaccgatgac aaagccgata tgataggctg acaggcactc cttgttgact
     6901 ccggtacatt ccatcaacgc acgcagcccc agattctttg ttcttttcag catctcgagt
     6961 ccctgcgcga cgaaaatccg gttctcatcc ctcagatcca taacatcccc gacggtagcg
     7021 atggctacat tctccatcag ataatccaca tcctccgggt cttttcccat cacgttgtac
     7081 aaagcctcga tgagcttata ggctactgct gctccgcaca gccccttgta cggatacagg
     7141 cagtcctccc gtttgatatc caccaccgcg tctgcgggag gaatctggaa ctccctcgtc
     7201 ccatcctcct tttcttcata gggtacctcg tgatggtcgg taacaatgat ggacatcccc
     7261 atgctttttc cgtaggcaat ctcattcttc gccgcaatcc cgttatcaca tgtaataatc
     7321 gtatcgatat catcatccaa agcccggtcg atcaaatcaa tattcagccc gtagccatcc
     7381 cggatccggt ctggaatatc ataatccacc cgggctccaa ggccggtaag cccttccaga
     7441 agaatatatg tggcattgac gccatcaatg tcataatccc cgataatgcg gatgctctga
     7501 ccttctgtga gcttctcttt cagcaaatcg acagccttgt ccatgtcttt catcagcatc
     7561 ccgtcgtaca gatccgcaat ggttccgttc aggtaccggt ccaccgcttc ctccccgata
     7621 atatcccggt tgcggatcag cgccgccgtc ctcggatgaa tatgaaaccg ctcccctatt
     7681 ttcgtaaaat tgccgccctt tctgagcagt acccagtttt tcatctgtat tcctccactg
     7741 aaaagcaaaa ggatgccgca agatcctggt gatccatcct gccgcatccc tttattcgct
     7801 ctatttcttt ttccctgttt ccgtttttac agcctctttc ttctttccga ctttcgtctt
     7861 catcacatac cagagcgcac ctgtaatgca caccgaagag tacgcgccac agatgatacc
     7921 cgccatcaga ggcagggcga actctctgac cgaagcaact ccaaagagga acaggaaaaa
     7981 taccatgata aaggtcgtaa gagaggtgta gatacttctt gtcagcgtca gtgtaataca
     8041 tctgtttaca agctcggcaa gagattcttt cttctttcgt acctttaatt cttcacggat
     8101 acggtcgaaa atcacaatcg tcgcattgat cgagtatccg acgatggtca gcatacaggc
     8161 gataaaggtg cttcccacgg taattctgga tactgcataa aacgcaagta ccaccagtac
     8221 atcgtgtact aaggccgcca ccgcactggt tgcaaaccgg atatccttaa accggagcca
     8281 gatgtaaaga agcatacaga tggtggaaat cacaaccgca atcaccgcat cttgtctcat
     8341 ctccgcactg atggtagagc tgatactgga ataggtaatt tccgaatcct tgatttcaaa
     8401 cttatctgcc agagcctggt ttaatgcctc tctttgctga aggctcaaag cctttgttct
     8461 gatgataatc tgattacttt cctttacttt ctgtgtctgt acttccgaat ctcctgttgc
     8521 ctcctcgata accggaacaa tctcggactc gatctcggaa atgctgtagt cttcatggaa
     8581 cgctacattc gtggacgtac caccctgaaa ctccagactg tagttcagca taccgttccc
     8641 tttgatctgg tgatatccca tcacgccaaa tccaaccacg atgaccgcca gagagatggc
     8701 aaaacagagc gctttcttgc tgaggaaatt gaccggcttt ctctctttcc atttctttgc
     8761 atagaatttc tcatcccgga ttcccactgc atagaaggag tatacaatca tccttgtaat
     8821 taccagagcc gtaaacatcg atatgacgat accgagcgcc agtgtctgtg caaatccacg
     8881 aactgtaccg gaaccacgga accaaagtac tgcagccgca atcaatgtcg taacattacc
     8941 gtccacaatg gctgagagcg ctttatggaa gccgcctttt aaggcgtttc gcacactctt
     9001 tcccgcggaa atctcctcct tcactctggc gaaaatgatg acgtttgcat ccaccgccat
     9061 gccaatggaa agaatgatac cggcaattcc cggtaaagac aacgtaatat caaatgcatt
     9121 tagcagcatc agcacaagcc ctgtgtaaat caaaagtgca agtcccgaag caagtcccgg
     9181 aagcagatag acgatcatca taaagaggat cacaaccgca agtccgacgg cacccgcata
     9241 caagcttgtg ctgatcgcct cttcaccgag ctgggctccc tctacctggg aattcagctc
     9301 ttccagctcc agggaaagtc cgccgatccg gatagaggcc gccaggttct ctgcttcttc
     9361 aaaagttgcc ataccgtcaa tatatgctgt tcctccggtg atcgcctcat tcactcttgg
     9421 ggaactgatc gtctccccat cataaataat ggaaatctgg tttcctatgt tctccttcgt
     9481 agcctcggca aacttcttgg atccctcttt atttagctgg agctctacca tatactcgtt
     9541 ggctcctgta gtatgatcct ggccgctttt tgcctcagca gtcttgatat cgcttcccgt
     9601 aagtaccgtt tccccgtcag acgtctggaa ctcaagagtt cccggctgac cgagttcttc
     9661 caggatttca ttggcgtccg atacacccgg tatggaaata ctgatccgtc tgtcgccttc
     9721 ctgatataca ctcgcctccg tgctgtaggt ctccacacgt ttttgcagct tgtagactgt
     9781 atccctcata tcttcatccg acgggttctt ctccttcgtc tgataggtga tactgacccc
     9841 gccggccaga tccaggccaa gtttgatatt tttcatagcc ccactgtggg atccgcccca
     9901 tccgaaactc actgtatagg ccaagagtgc tatcatcaga atcgtcccaa gaagtcctgc
     9961 gatccctctg cttttcttca tatcttacac ccccttctct ttaagcctgc cggctctctt
    10021 ccccgatgtc cgccaaagca gcttttatca taatcgcaca ctctactctt tttctctcca
    10081 tctcacatcc gatatcataa gcatcatgta aggttccctc gaaatggtag gagtttgcca
    10141 tacagccgcc gctgcaataa aatctggcga agcagttacg gcatttctcc ttggagtata
    10201 cattgcagca ccggaactca tccgcaatct caggctttgt aatgccatcg tctacatttc
    10261 ccatcaggaa gtcctcatcc cctacaaact ggtgacatgg atagagatct ccccacggcg
    10321 ttactgccag gtactctgtg ccggacccac atccggaaag acgtttggca atacaaggac
    10381 ctccttccag atcgatcata aaatgaaaga aattgaatcc ttttccttcc ttttctctct
    10441 ggatcatata gcttgcaagc ttatcgtatt cctcgaaaat ctgcggcaaa tcttccttgc
    10501 gaatagcata aggatctgtc tcatccccta ccaccggctc aatggacatc tgctgaaatc
    10561 ccagatctac gaaatggcgt acgtcctcag aaaagtccag attctgtctg gtaaacgttc
    10621 cccggacata atatttctgc tggttcctgc tctttgcaag cttctggaat ttcggaacaa
    10681 tcaaatcata gcttcctttt ccattgcgaa atggccgcat cctatcattg atctcccgtc
    10741 ttccatccag acttaacacc acattgtcca tctcctgatt gataaactcc tggacctcgt
    10801 cgttcaaaag cacgccgttt gtggtaacag taaatcggaa atgcttgtcg tgaatcttct
    10861 cctgctctct tccgtatgcc accaggtctt tgacaacctg ccagttcatc agaggctcgc
    10921 cgccaaagaa atctacttcc aggtttcttc tgctgccgga attggcgatc aggaaatcca
    10981 gtgctttctt tccgacctca aaagacataa gcgcccgtct tccgtggtat tctccctctt
    11041 cggcgaaaca gtacttgcaa gccaggttgc agtcatgcgc gatgtggagg cagagcgcct
    11101 tcactactgt ctttcttttc attacgtcct ggatgcaggc ttcgtgcgta tccggtgcaa
    11161 aaagctgtcc ggcctcggta agctcggcaa gatcgtcaag aaccgtgtca atttcctccg
    11221 gctcatatgt attttcaaac tgtgctttta ttgcttctct cgttttggcc gtctgtattg
    11281 tgctggccgt ctgctccgga tggatcgcgt ttaaggcggc gattacatcg tatcccatct
    11341 ggtctacgac atgcacgcac ccactgttga catccagaac aatattgtat ccgttattct
    11401 ggtactggtg aatcactatc ggtacccctt tcttttttct ttgaacatca agagacagcg
    11461 accaaaaagc cgctgtcttt gtacccttcg tttataagtc ctgactgcct atttcttctg
    11521 ctcgcaggtc tggtttccta ctgtacagga agtcttacat gctgactggc aggatgtctg
    11581 gcattctccg catccgccct tcttcatcgt gttgtttaag gtctgtgtat ttaatgtttt
    11641 aatgtgtttc atcctgattt cctccttctg ccttttgcta gaagatatta tagcatagcc
    11701 tccttctttt taaaagccct tttttcgcaa tctcacggat gacctttgca ggccgtttga
    11761 tggcgccgca catcttttgt tctctatgac aacataccgc ccaacatccc acctgcggcg
    11821 cacagtacca atgtcgtcac gatctgcatc acatctccct gaagggtgtg atatacgcca
    11881 aaggagacca gtaccagcag aaggaaatac aaaatcccaa gcatgagccc ccagataaat
    11941 ttgcggactt tctgaagctt tccgattaaa aatcctccgg caaatgcgga gacaacataa
    12001 attccggtaa tccctgccgt cactttgccc ttatccagat tcagtttata aagcagcact
    12061 gccagcacca agagcaggat tccggtaatg atataagata ccagaagtgc ctgaaaaatc
    12121 cgcataaccc ctgatttttg tccctttact ctcatcgcat cctccttgtc ctgtttctaa
    12181 gactattgta tgatgcgggc ttgcgcttta tgactatgct tccatctgac ttccgagaaa
    12241 tgtggcagca cactgggcaa gcttctgaca gatttccttg gatgctccct tctcctcttc
    12301 ctgccacaaa aaaacgacag cgccgatcac atcgcctccc gtaagaaccg ggcacaccag
    12361 gctctcaagg tagtccagat tcttatattt cagcaaagga accatcccct tttctctcac
    12421 ccctttttgt accatccggc gttcctccag aagtcccacg aactcctctg aaatctcctg
    12481 gtccgctaca tcctttttcc ctgccccgga cgcagcgatc accttttcca tgtctgtgat
    12541 acacgtcagc actcccgatg cctgggaaag gctctccgca taattctgtg caaatgtata
    12601 aatttctcca agcggggaat attttttcag aatcacttct ccatcttttc ctgtaaaaat
    12661 ctctaaaggc gtgccctccc gaatccccag tgtccttcgg atttcctttg gcacgacgac
    12721 tcttccaaga tcatcgattc ttcttacaat tccggttgct ttcatatcgg tcttgttccc
    12781 tccatttcac aatataaccg ttattttcca cggttccaca taaggctagt atccgcaaaa
    12841 ggaaaaattt tattctgttt gcactttttc ttaagagata gtaaaataga aaaaaacacg
    12901 aggaggtcga gcagacgatg agtaaaattg acgacgtaag aaaagaaatg gtcgttgcca
    12961 tgaaagccgg cgacaaagca agaaaagaga cgctctcttc tcttcttgcc gctctcaaaa
    13021 ataaagctat cgacaaacgg gaggatctga cagccgagga agaggtgcag gttgtattaa
    13081 aggagatcaa gcagacgaaa gagactctgg agatgacccc ggcggaccgc gctgagatca
    13141 tcgccgagtg cagggctcgc atcgcagtcc tcgaagagtt tgcgccaaag atgatggatg
    13201 aagaagagat caaaactgtg atctcctccg tcctctccga tctggagctg acaacgccga
    13261 ctgcaaaaga taaaggaaaa ataatgaaag agctgatgcc gaaggtaaaa ggaaaagccg
    13321 acgggaagct cgtaaatgag ctggtcagca cgttctttgt ataacgcctt catcagatga
    13381 taaccataaa agaagcagcc tactcggctg cttcctctgc gttatctgta ttgtccgtat
    13441 tctcggaatc gtctgtattc tcttcatccg tactgtcttt actagtagag ttatccgtac
    13501 tgtcggagtc atcctccgct ttcttcaccg caaccccttg ttcgttaaag tcgatttttt
    13561 tccagacgtc cttattttcc ttaatcttgg tatcgtcttt ccatccctcg acgatctcat
    13621 tgtaacggtc attctcccgt tcggagatga tctgctgctt cttattatct gtggctgtct
    13681 gatcaaatgt ggaagtcacc tttgccacat agtatccgga atcggtctcg atcacgtctg
    13741 tcacctgtcc tgcatccagc ttgtcagccg cagcgatgac ttcctcgttc ggagacgtcg
    13801 tctcagaatt aaaggtcaga tccagcgtgg aggtttcctg gtcttttgct gcctgctcaa
    13861 aatccgtgcc tcccttaact gcatctaaga atgtatctgc ttttgtctta gcctcttcct
    13921 ttgtatcgga tgtgctctca gagtcctcgc tctttgactc ctcggaataa gtaaatgcca
    13981 catactgcat cgctttctga gccgcctctt catcggaaac cttgcggtct acatccttta
    14041 acatctctgt ccgcatcttc tgctggatcg taaacaatcg aagaacttct tccaccgtct
    14101 ctttatcccc tgagatcact tcccggacat tttcgccgtt cgcttctacg aaagcatctg
    14161 ctgcctcccc gattgctttt ttctcgtcct ctgtcaggga aacatcataa tcccccacgt
    14221 gttcatttaa aagataaagc tcctccagag actgcataat tgtctctttc gccgactctt
    14281 cataagtcgt atcgtcgtcg acttttgtcg tccacatatt ttctcccagc atggaactgt
    14341 aataagtctc atacattgcc tgctgatatc ttgcaaagaa atttgctata ttccctttaa
    14401 tctctgtttt acctactgtc gcaacaacgt cgctgtcctt aatcgtctct tgcccgcagc
    14461 ctgccattgc ccccgccgct atcacggcag tcagaaggac aactgccaaa cgctttttca
    14521 taatatcaaa agcctccttc gtatttctaa ctaccctatt atatccggtt tcccttttac
    14581 aatcaatgtt tttatgtcat ttaacagatt tttcacgact tccaggatat cctgatcttt
    14641 ctctttgcga tttcgctttt tctgctcgta aaggaaatat ggaggtgcgt catttttgaa
    14701 tagcaattct ccttttcttc gctccagaag tttgggaatc tcctgaacct gcacttttgc
    14761 cttttcatac atcgtgattt tgagcgtgct gcctttttgc tcgatggccg tcacatacac
    14821 ggagtgggca agagccttga tccgtgcaat caagatgagt ttctgtactt tcttaggaat
    14881 atccccgaag cggtcgatga gctcttccat catatcgtcc atctcgtctt ctgtactgat
    14941 gagggcaatc cgcttgtaaa tatcgagttt ttggtactcg tccggaatat aggaggccgg
    15001 aataaatgca tccacattca ggtcgatcgt cgtggtaaag ctctccacct catcctgatc
    15061 tataccttgt ttcatgcctt taactgcctc gtttaacatt ttacagtaga gatcataccc
    15121 tactgcctcc atgtggccat gctgtgcttc tccgagaaga tttcctgctc cccgtatttc
    15181 cagatccctc atggcaatct taaatcccga tcccagatcg gtaaactccc gaatcgccgc
    15241 cagacgtttc tccgccacct cccgtaaaag ccggtctctc cgataaagga gaaaagcata
    15301 ggccatcctg ttggaccgtc ctacacggcc ccgaagctgg tataactgag aaagccccag
    15361 tttgtccgcg tcgtggataa tcatcgtatt gacattagaa atatcaagcc cggtctcaat
    15421 aatggttgta gagacgagca cgtcgatatc cccattgatg aaatcataca tgatcctttc
    15481 caactgatgc tcccgcatct gcccgtgagc gtaagccaca tttgcctccg gaatcagact
    15541 ctggatacgg gctgtgatct ccgcaatgtc ttttacctta ttataaacat aatagacctg
    15601 cccctgtctg gagagttccc gcacgatggc ctcccgtacc atctcatcct gatattccat
    15661 gacatacgtc tggatcggca tcctgtccat cggtgcttcc tccagcacgc tcatatcccg
    15721 aattccgatg aggctcatgt ggagggttcg tggaatcggg gtagccgtca gtgtcagaac
    15781 gtccacattt tcccggagct tttttatctt ctccttgtgt tgaacaccaa aacgctgctc
    15841 ctcgtcaatc accagaagtc ccagatcttt aaacgtcaca tcccgactta aaatccggtg
    15901 ggtccccaca agaatatcca cctgcccttt catcagatct tccagtgtct tcttctgctg
    15961 agcaggcgtc cggaaacggc acatcagatc taccctgacc ggaaaatcct tcattctctg
    16021 cacaagtgtg ttgtaatgct gctgtgccag aatggtggtc ggcacgagaa atgcaacctg
    16081 cttattctcc tgtacagcct taaaagcggc tcggatcgcc acctcagtct ttccaaatcc
    16141 cacatctccg cagatcagac gatccataat cttatggctt tccatatcct ttttcgtatc
    16201 ctcgatggcc gccaactggt catccgtctc ctcaaaggga aacatctctt caaactcttt
    16261 ttgccataca gtatccggct cgtaggcata gccgtccttt tcctgacgcg tcgcataaag
    16321 ctctacgaga tctcttgcaa tctcctgtac ggcttttcgt acccgcgtct tcgtcctctc
    16381 ccagtcctgg cctcccagcc ggttcaactt gggcttcttt gcatccgcgg aagcgtactt
    16441 ttggatcaga tccatctggg tggccggaat ataaagattg ccgcccccgg cgtaggagat
    16501 tttcatataa tccttctcaa tccggtccac ttcaatcttc tcgattccct gatagatacc
    16561 aaggccatga ttttcgtgta ccacatagtc ccccggcttt aaatccgtaa aactctggat
    16621 cttctccccc tcatagatct ttctgcgctt ctttctcttc ttttttccga agatatccgt
    16681 ctcagagata acggtgaatt tcagcatcgg atattcataa cccactgcca cgtggccgta
    16741 ggagacaaaa atctcccccg gctttaccag gcggtttgga tcttcatcat aaaagctgtt
    16801 taaatcataa tcccgcagat cttctgccaa tctcctggct cttgtccggg agccactcag
    16861 aaggatcacc cggtatccat ttcgcttcag ccgcttcaaa tcccttgtca ggacttcaaa
    16921 actgctgtta tatgggttga cattctttgc caggatactg taagtctccc gcacatggaa
    16981 ttccttcagt tttccttcca gcgcggtaaa cccaatacta tgatagctat ttaaaagccc
    17041 cacaatctca cgcaccagaa acatccggat ctcatcctcc tctgtctttg aggtccgctc
    17101 cgcttcctct cttctttcct gcgcctcttt gacctcctcc tcgattgtca gccctctctc
    17161 atataacctt gcaggctcat ccaaaaacag aagtgtctcc tccggctgaa aatactgcaa
    17221 aaaagaaact ccttgttttc cggagactgt atccgatgcc gggtagaaag tgatctcctc
    17281 ccggttttcc acagaccgct gcgtctccac gtcaaacgtc cggatggagt cgatctcgtc
    17341 atcccagaat tcaatccgca ccggcatctc ttctgtcagg gggtacacgt ccaaaatccc
    17401 acctcgtaca gcaaactgcc ctggtccttc aatctggatt tctctgtcgt atcccatctt
    17461 ggaaagtcta acctttaatt cctccaggtc cgacatgtct cccacgcgca gggtaaagat
    17521 ctgtccattg atgccggacg gaggacggac gccgtccatc aaagcatcga ttgtcgtcac
    17581 caccgtgacc ttctcctcct cccgaagcgc ccgaatcact tccatcctct tctgagtcag
    17641 atattttccc cggatatccg cacggtaaaa cagaaaatcc tttgccgggt agaaaaagac
    17701 cccggcatcc agaaactggt attcctccaa gatctccttt gccttttcct catcctgcac
    17761 aacataaagc acccgtctgt cctccctggc aagggcatag gcgaggtgtc ctttctgtga
    17821 tccggtactt ccggcaatct gaatcatccc cggttcccgg tattttgtct tctgaatagt
    17881 atcaaactcc gcaagctcca aaagaggcgc cgtaaaagcc ttcatcgtgt cttactccct
    17941 tccatcaacc tttgcggtta aactgattca tcgcctcaca gatgtcacca tgtaaagcca
    18001 tcctcacggc ctgtaccgcc ttttcgtagg cttcctccat cttctctttg tcctctcctt
    18061 caaaatgtcc cagcacataa tccgccagat cgtagcccct tggcttttct ccgactccga
    18121 tcttgatccg caaaaacgcg tcatgtccca gatgggagat gatgctcttg ataccattat
    18181 gtccgccggc gcttcctttt ttgcggatcc ggagctgtcc cacatccagg ctgatatcgt
    18241 cataaatgac aatcagatcc gtttcctcgt ccaccttata atagtccacc aactcccgga
    18301 tactctctcc gctcagattc ataaaggtct gaggctttgc gagtatcact ctgaagccgt
    18361 cgatcacacc cctgccgatg agcgcccggt gctttctcgt gtccactgct atatggtatt
    18421 cctccgcaat tttgtctatg acatcaaacc ctacattgtg cctggtccct tcgtatttta
    18481 atcccggatt tcctaatcct acgatgataa acatgacttt ctacctctct tttttcgtat
    18541 ctttttattt taccgtaaaa accctctttt ggcaacgctg catacaacgt acacaaaaat
    18601 cttcgttttc aaacaagttt gaactcagat tttttgtgac tttgtgcatg gctgaactgt
    18661 tactttcata tatagtataa aggcaacatc tcactgtact gccagatttg acatcttacc
    18721 gaaaggagag cttttgactt atgagttcca aaacaaaaat cgtcgtattt cacatgaagg
    18781 agatcatcta caccgccatt tttgccgccc ttgggatcct cctcatcctg cttctgctct
    18841 ttatgttcct gcccggacat acaaaaggaa agcagacatc caaagactat aagcccggaa
    18901 tctacactgc cagcatgaca ctcaataata cacctctgga agtggaggtg tccgtggaca
    18961 aaaaccatat caattcgatc cggtttgcca acctggacga aagcgtggaa acgatgtatc
    19021 cccttgtcca gccggccatg gaagaaatcg ccggacagat tatcaagtcc cagtcgacag
    19081 acaagatcaa agccggcgag gatgactcct atacatccaa tctcatcttg gatacaatcc
    19141 agaaggcact gaaaaaagcc gaggcagact gatatgctgc cccggctttt cctatccttc
    19201 cacgaccaga tactgtcctc ccggaagtgc gaacacttcg gatgcgtcct caatctcccc
    19261 aagtgtcata ccgtccacat ccgctccgta ctcatccaga taatctcgaa cctcttctaa
    19321 agaatccagt acgactgcca tacagtcctc cagaaaagcc tccgcctcct ccggcgtctc
    19381 tgccaccggc tcgtcaaata gctgggattg ttctcttaag aacacttcca aacattcttc
    19441 actaaatctc tccatgcgtc tcctccttgc ccttttgtac tgtcaccacc gaaatcagct
    19501 cttccgggtg atcgatcacc acatgggccc ctgtctcata cagaagctct ttggaacgaa
    19561 atccccaact gacaccgaca gttttaactt ttgcattgtt tccggtgtgc atatccacat
    19621 ccgaatctcc gatgtaaaca cactcctccc gtgtgatgcc cgcgcgttcc agaatggaaa
    19681 gcactgccgc cggatccggc tttctcggaa tcccttcctt ttgtccctgc acggcatcaa
    19741 agaaatgatc tccaaaaaag gttcgtacca catccctcgt ttggccgtcc ggcttattgg
    19801 aaagaactgc cagaaagacc ccttctttct ttaatcgctc aagcatctct ttgattccat
    19861 catatggctt tgcgtgatag gtgcaatatt ttgcaaaaac atcgccgtag actgccatgg
    19921 cctcttccat acgggacatc tcttcatccc cacacgcccg cagggtacac tccaaaagct
    19981 ttctagcgcc gtttcccaca aacctcctgc actgttccat cgtaattgga ggaagtccca
    20041 tcctttccat ggtcagattc acagaataag taatggattc taatgtatct gtcaatgttc
    20101 cgtccaaatc aaaaatacaa gctttataca tctttctcac tccattctct tgtttcatac
    20161 catttacaag tatagcataa tataggatct ggaaaatttc aacacaaaag aacgccccca
    20221 gggaaaagtt agtcgctgtt ccctgaaaac gttctgttgg tttttctgtc tgatcgtttc
    20281 ttttcaatcc agatactggc gcatcagacg aagtgcgttt ttctccaacc tgctcacctg
    20341 cgcctgggaa atcttcactt cctttgccac ctccatctga gtcttcccct cgaagaaccg
    20401 aaggcggata atatatttct cccgctcatt taggtgctcc atcgccgcct gcaaggacag
    20461 atcctcaatc cagcgctcct ctttgttttt cttatcgctg atctgatcca tcacatagag
    20521 tgcatccccg ctgtcattgt ataccggttc gtttagactc accggagcct gaatggcgtc
    20581 cagagcaaag acaatatcct ccttggaaat gccaatttcc tcggatatct cctggacagt
    20641 cggctcccga agattcttct tgacgtagtt ttccttggcg tagatcgcct tgtacgccgt
    20701 gtcccgcaac gaacggctga cccggatgga attattgtcc cgcatatacc tgcggatttc
    20761 accgataatc atcggcaccg cataagtaga gaaacgaaca tccagctctg tattaaaatt
    20821 gttgaccgcc ttgatcaggc cgatacagcc aatctgaaac agatcgtccg gattttcgct
    20881 gctccccgca aaccgcttga ttacacttaa cacaagtctt aaatttcctt taatgtactt
    20941 ctcttttgct tcctcatcgc cctccttaat ccgggcgaaa agttcttcct tttcttcctc
    21001 tttcagaagc ggaagctttg aagtattcac tccgcatatt tccaccttgt tcagtgccat
    21061 cgtacatcct cctgtcacag caaatctgcc tttctaacag aaatgatgtg cataccggca
    21121 cactcttata caatgatgga aaaaataaaa aaacttttag tccttgacat gttgcacgtt
    21181 cggatactct gatcagtcgt tccgatccca cttgtctgca agatttaaaa tctgactttc
    21241 caacttagca agatctttat tagatagccc ttcgtttttc attaccacgt caagcagcct
    21301 cttcgccgcg gataccgcac ggccaaatat ctgatttgcc cggattctgg caggtttttc
    21361 cgcagatttc ttcggaatcc tgagtccctc gcttaagatc tcatccgtca gaagatccac
    21421 ggctccccca gaatacggag caaaagcctc atatccgagc gtctccttga tggaagccgc
    21481 aaactcgtcg gtcacctgat cctccccgtg gacgacaaac acatgacgga tcggagtctc
    21541 aaaggcggac agccagttta aaagcccgtt tttgtccgca tgtccactga taccctccaa
    21601 ggcgcagatc ctggcattaa cctccacatt ttcaccgaag agtttcacac at
//
