Select genomic region:
Overview
2.1
35.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JADNBL010000011.1 (Bifidobacterium longum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-ii | 60,864 | 83,965 |

NZ_JADNBL010000006.1 (Bifidobacterium longum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 35.1 | terpene-precursor | 61,797 | 82,879 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-ii | 60,864 | 83,965 |
Region 35.1 | terpene-precursor | 61,797 | 82,879 |

No secondary metabolite regions were found in these records:
  NZ_JADNBL010000010.1 (Bifidobacterium longum)
  NZ_JADNBL010000012.1 (Bifidobacterium longum)
  NZ_JADNBL010000013.1 (Bifidobacterium longum)
  NZ_JADNBL010000014.1 (Bifidobacterium longum)
  NZ_JADNBL010000015.1 (Bifidobacterium longum)
  NZ_JADNBL010000016.1 (Bifidobacterium longum)
  NZ_JADNBL010000017.1 (Bifidobacterium longum)
  NZ_JADNBL010000018.1 (Bifidobacterium longum)
  NZ_JADNBL010000019.1 (Bifidobacterium longum)
  NZ_JADNBL010000001.1 (Bifidobacterium longum)
  NZ_JADNBL010000020.1 (Bifidobacterium longum)
  NZ_JADNBL010000021.1 (Bifidobacterium longum)
  NZ_JADNBL010000022.1 (Bifidobacterium longum)
  NZ_JADNBL010000023.1 (Bifidobacterium longum)
  NZ_JADNBL010000024.1 (Bifidobacterium longum)
  NZ_JADNBL010000025.1 (Bifidobacterium longum)
  NZ_JADNBL010000026.1 (Bifidobacterium longum)
  NZ_JADNBL010000027.1 (Bifidobacterium longum)
  NZ_JADNBL010000028.1 (Bifidobacterium longum)
  NZ_JADNBL010000029.1 (Bifidobacterium longum)
  NZ_JADNBL010000002.1 (Bifidobacterium longum)
  NZ_JADNBL010000030.1 (Bifidobacterium longum)
  NZ_JADNBL010000031.1 (Bifidobacterium longum)
  NZ_JADNBL010000032.1 (Bifidobacterium longum)
  NZ_JADNBL010000033.1 (Bifidobacterium longum)
  NZ_JADNBL010000034.1 (Bifidobacterium longum)
  NZ_JADNBL010000035.1 (Bifidobacterium longum)
  NZ_JADNBL010000036.1 (Bifidobacterium longum)
  NZ_JADNBL010000037.1 (Bifidobacterium longum)
  NZ_JADNBL010000038.1 (Bifidobacterium longum)
  NZ_JADNBL010000003.1 (Bifidobacterium longum)
  NZ_JADNBL010000004.1 (Bifidobacterium longum)
  NZ_JADNBL010000005.1 (Bifidobacterium longum)
  NZ_JADNBL010000007.1 (Bifidobacterium longum)
  NZ_JADNBL010000008.1 (Bifidobacterium longum)
  NZ_JADNBL010000009.1 (Bifidobacterium longum)

Compact view
NZ_JADNBL010000011.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 60,864 - 83,965 nt. (total: 23,102 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
I2A13_RS07640: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000588.5 |  | 0.48 | ribosomal | microcin L | Escherichia coli
BGC0000528.5 |  | 0.48 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001210.5 |  | 0.47 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000504.5 |  | 0.46 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000626.3 |  | 0.45 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000501.3 |  | 0.45 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000500.5 |  | 0.44 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000588.5 |  | 0.48 | ribosomal | microcin L | Escherichia coli
BGC0000528.5 |  | 0.48 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001210.5 |  | 0.47 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000504.5 |  | 0.46 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000626.3 |  | 0.45 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000501.3 |  | 0.45 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000500.5 |  | 0.44 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for I2A13_RS07640

I2A13_RS07655
Leader:
MSINEKSIVGESFEDLSAADMAMLTGRNDDGVAPA
Core:
S L S F A V S V L S V S F S A C S A T V V T R L A S C G N C K
Core with dehydrations:
Dha L Dha F A V Dha V L Dha V Dha F Dha A Cys Dha A Dhb V V Dhb R L A Dha Cys G N Cys K

#### antiSMASH-DB 4.0 matches for I2A13_RS07655

100.0%
NZ_CP046514.1 and 12 others:
NZ_CP083257.1 Lanthipeptides: BCBL_RS08920_lanthipeptide NZ_CP084012.1 Lanthipeptides: LCQ81_RS01125_lanthipeptide NZ_CP084020.1 Lanthipeptides: LCQ52_RS09765_lanthipeptide NZ_GL622638.1 Lanthipeptides: HMPREF0177_RS02885_lanthipeptide NZ_JADMSA010000006.1 Lanthipeptides: I2H42_RS05020_lanthipeptide NZ_JADMUN010000007.1 Lanthipeptides: I1M16_RS07360_lanthipeptide NZ_JADNBL010000011.1 Lanthipeptides: I2A13_RS07655_lanthipeptide NZ_JADPBZ010000019.1 Lanthipeptides: I4V99_RS08285_lanthipeptide NZ_JADPCP010000015.1 Lanthipeptides: I4W34_RS09795_lanthipeptide NZ_JADPFY010000033.1 Lanthipeptides: I4V11_RS10065_lanthipeptide NZ_JAHTKJ010000004.1 Lanthipeptides: KUF58_RS04255_lanthipeptide NZ_SPGO01000021.1 Lanthipeptides: FGQ71_RS09210_lanthipeptide
Lanthipeptides: GN236_RS08545_lanthipeptide
1
S L S F A V S V L S V S F S A C S A T V V T R L A S C G N C K
31
S L S F A V S V L S V S F S A C S A T V V T R L A S C G N C K
1
S L S F A V S V L S V S F S A C S A T V V T R L A S C G N C K
31
96.8%
NC_010816.1 and 5 others:
NZ_CP069278.1 Lanthipeptides: JQN89_RS04800_lanthipeptide NZ_JADNCJ010000029.1 Lanthipeptides: I2B64_RS09750_lanthipeptide NZ_JADNLW010000041.1 Lanthipeptides: I2F45_RS10575_lanthipeptide NZ_JADPBO010000046.1 Lanthipeptides: I4V38_RS08850_lanthipeptide NZ_JADPES010000050.1 Lanthipeptides: I4U88_RS09655_lanthipeptide
Lanthipeptides: BLD_RS08345_lanthipeptide
1
S L S F A V S V L S V S F S A C S A T V V T R L A S C G N C K
31
S L S F A V S V L S V S F S A C S T V V T R L A S C G N C K
1
S L S F A V S V L S V S F S A C S V T V V T R L A S C G N C K
31
32.3%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: J5V93_RS29680_lanthipeptide
Lanthipeptides: EXW47_RS29590_lanthipeptide
7
S V L S V S F S A C S A T V V T R L A S C G N C K
31
S+L V S + C S C N C K
4
S I L K V S R A V C K T G T C I C T T S C S N C K
28
with 2 more sequence matches
32.3%
NZ_KB976165.1 and 1 other:
NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17675_lanthipeptide
Lanthipeptides: ICC_RS37095_lanthipeptide
6
V S V L S V S F S A C S A T V V T R L A S C G N C K
31
S+L V S + C + S C N C K
3
T S I L K V S R A P C K S G T C L C T T S C S N C K
28
17.0%
NZ_CP110813.1:
Lanthipeptides: allorf_3539006_3539200_lanthipeptide
18
A T V V T R L A S C G N C
30
A T R L A+ G N C
6
A A W P T R L A A E G N C
18
allorf_61109_61330
Leader:
MAFLPKSAVDLEFG
Core:
T F G R A T K K P C A Q A E Q Y N L A K R P S P A L D G L I S L N L R W L G E P N F G N A L A R T S T N G L W F T D D
Core with dehydrations:
Dhb F G R A Dhb K K P Cys A Q A E Q Y N L A K R P Dha P A L D G L I Dha L N L R W L G E P N F G N A L A R Dhb Dha Dhb N G L W F Dhb D D

#### antiSMASH-DB 4.0 matches for allorf_61109_61330

100.0%
NZ_CP046514.1 and 9 others:
NZ_CP069278.1 Lanthipeptides: allorf_1033752_1033973_lanthipeptide NZ_GL622638.1 Lanthipeptides: allorf_31875_32096_lanthipeptide NZ_JADMSA010000006.1 Lanthipeptides: allorf_049253_049474_lanthipeptide NZ_JADMUN010000007.1 Lanthipeptides: allorf_076793_077014_lanthipeptide NZ_JADNBL010000011.1 Lanthipeptides: allorf_61109_61330_lanthipeptide NZ_JADPBZ010000019.1 Lanthipeptides: allorf_14831_15052_lanthipeptide NZ_JADPCP010000015.1 Lanthipeptides: allorf_17792_18013_lanthipeptide NZ_JAHTKJ010000004.1 Lanthipeptides: allorf_025782_026003_lanthipeptide NZ_NJNX01000015.1 Lanthipeptides: allorf_53588_53809_lanthipeptide
Lanthipeptides: allorf_1935663_1935884_lanthipeptide
1
T F G R A T K K P C A Q A E Q Y N L A K R P S P A L D G L I S L N L R W L G E P N F G N A L A R T S T N G L W F T D D
59
T F G R A T K K P C A Q A E Q Y N L A K R P S P A L D G L I S L N L R W L G E P N F G N A L A R T S T N G L W F T D D
1
T F G R A T K K P C A Q A E Q Y N L A K R P S P A L D G L I S L N L R W L G E P N F G N A L A R T S T N G L W F T D D
59
15.3%
NC_009480.1 and 1 other:
NZ_CP047054.1 Lanthipeptides: allorf_2242448_2242588_lanthipeptide
Lanthipeptides: allorf_2226592_2226732_lanthipeptide
25
A L D G L I S L N L R W L G E P N F G N A L A R T S T N G L W
55
A L ++ + G P N A++R + G W
3
A L R T S V A R S A E L E G R P A R R N A V S R A T A T G Y W
33
15.3%
NZ_PSTW01000024.1:
Lanthipeptides: allorf_20775_20915_lanthipeptide
25
A L D G L I S L N L R W L G E P N F G N A L A R T S T N G L W
55
A L ++ + G P N A++R + G W
3
A L R T S V A R S A E L E G R P A G R N A V S R A T A T G Y W
33
with 1 more sequence matches
13.6%
NZ_AP018365.1 and 3 others:
NZ_AP018365.1 Lanthipeptides: allorf_8002653_8002877_lanthipeptide NZ_AP018365.1 Lanthipeptides: allorf_8002653_8002877_lanthipeptide NZ_AP018365.1 Lanthipeptides: allorf_8002653_8002877_lanthipeptide
Lanthipeptides: allorf_8002653_8002877_lanthipeptide
4
R A T K K P C A Q A E Q Y N L A K R P
22
R A T+ P C A R P
16
R A T R A P C A T G T D D V S G P R P
34

#### MIBiG 4.0 matches for allorf_61109_61330

8.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
24
P A L D G L I
30
P A+ G L I
3
P A V T G L I
9
6.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
52
N G L W F T
57
N G W T
15
N G G W C T
20
allorf_62374_62448
Leader:
MGLCGAAHRVHNAAAG
Core:
P G E N C D S P
Core with dehydrations:
P G E N Cys D Dha P

#### antiSMASH-DB 4.0 matches for allorf_62374_62448

100.0%
NZ_CP046514.1 and 9 others:
NZ_CP069278.1 Lanthipeptides: allorf_1035017_1035091_lanthipeptide NZ_GL622638.1 Lanthipeptides: allorf_33140_33214_lanthipeptide NZ_JADMSA010000006.1 Lanthipeptides: allorf_048135_048209_lanthipeptide NZ_JADMUN010000007.1 Lanthipeptides: allorf_078058_078132_lanthipeptide NZ_JADNBL010000011.1 Lanthipeptides: allorf_62374_62448_lanthipeptide NZ_JADPBZ010000019.1 Lanthipeptides: allorf_13714_13788_lanthipeptide NZ_JADPCP010000015.1 Lanthipeptides: allorf_16675_16749_lanthipeptide NZ_JAHTKJ010000004.1 Lanthipeptides: allorf_024665_024739_lanthipeptide NZ_NJNX01000015.1 Lanthipeptides: allorf_54853_54927_lanthipeptide
Lanthipeptides: allorf_1936928_1937002_lanthipeptide
1
P G E N C D S P
8
P G E N C D S P
1
P G E N C D S P
8
allorf_64006_64134
Leader:
MGIVVNRQLNVHGS
Core:
S T S A L F N I E I C S A K K P K N Q K A S I P N E T V
Core with dehydrations:
Dha Dhb Dha A L F N I E I Cys Dha A K K P K N Q K A Dha I P N E Dhb V

#### antiSMASH-DB 4.0 matches for allorf_64006_64134

100.0%
NZ_JADNBL010000011.1 and 1 other:
NZ_JADPCP010000015.1 Lanthipeptides: allorf_14989_15117_lanthipeptide
Lanthipeptides: allorf_64006_64134_lanthipeptide
1
S T S A L F N I E I C S A K K P K N Q K A S I P N E T V
28
S T S A L F N I E I C S A K K P K N Q K A S I P N E T V
1
S T S A L F N I E I C S A K K P K N Q K A S I P N E T V
28
71.4%
NZ_CP046514.1 and 6 others:
NZ_CP069278.1 Lanthipeptides: allorf_1036649_1036768_lanthipeptide NZ_GL622638.1 Lanthipeptides: allorf_34772_34891_lanthipeptide NZ_JADMSA010000006.1 Lanthipeptides: allorf_046458_046577_lanthipeptide NZ_JADMUN010000007.1 Lanthipeptides: allorf_079690_079809_lanthipeptide NZ_JADPBZ010000019.1 Lanthipeptides: allorf_12037_12156_lanthipeptide NZ_JAHTKJ010000004.1 Lanthipeptides: allorf_022989_023108_lanthipeptide
Lanthipeptides: allorf_1938560_1938679_lanthipeptide
1
S T S A L F N I E I C S A K K P K N Q K A
21
S T S A L F N I E I C S A K K P K N Q K
1
S T S A L F N I E I C S A K K P K N Q K G
21
allorf_64040_64156
Leader:
MAAARVPYS
Core:
T S K Y V A R R S R K T K R L L Y R M K R Y R S L L V C D
Core with dehydrations:
Dhb Dha K Y V A R R Dha R K Dhb K R L L Y R M K R Y R Dha L L V Cys D

#### antiSMASH-DB 4.0 matches for allorf_64040_64156

100.0%
NZ_JADNBL010000011.1 and 2 others:
NZ_JADPCP010000015.1 Lanthipeptides: allorf_14967_15083_lanthipeptide NZ_NJNX01000015.1 Lanthipeptides: allorf_56513_56635_lanthipeptide
Lanthipeptides: allorf_64040_64156_lanthipeptide
1
T S K Y V A R R S R K T K R L L Y R M K R Y R S L L V C D
29
T S K Y V A R R S R K T K R L L Y R M K R Y R S L L V C D
1
T S K Y V A R R S R K T K R L L Y R M K R Y R S L L V C D
29

#### MIBiG 4.0 matches for allorf_64040_64156

17.2%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
24
S L L V C D
29
S L L V C+
6
S L L V C E
11
allorf_79901_80134
Leader:
MSWSGRSICLRLCCIAGDGGAGHHLSCFRNANRASGA
Core:
C L R A I M T L L P R I R I R R I V A R I M V R A M A S N R S Y R R L A Q H A R
Core with dehydrations:
Cys L R A I M Dhb L L P R I R I R R I V A R I M V R A M A Dha N R Dha Y R R L A Q H A R

#### antiSMASH-DB 4.0 matches for allorf_79901_80134

100.0%
NZ_JADMUN010000007.1 and 1 other:
NZ_JADNBL010000011.1 Lanthipeptides: allorf_79901_80134_lanthipeptide
Lanthipeptides: allorf_095586_095819_lanthipeptide
1
C L R A I M T L L P R I R I R R I V A R I M V R A M A S N R S Y R R L A Q H A R
40
C L R A I M T L L P R I R I R R I V A R I M V R A M A S N R S Y R R L A Q H A R
1
C L R A I M T L L P R I R I R R I V A R I M V R A M A S N R S Y R R L A Q H A R
40
allorf_80770_81003
Leader:
MVEHDIGVECAILETKELVCG
Core:
R L A V F I S N R R R S P D I K Y G C V S M L P L C G D V S G V S N S D M V R P Y E H M Y G L C R P P K H G C D
Core with dehydrations:
R L A V F I Dha N R R R Dha P D I K Y G Cys V Dha M L P L Cys G D V Dha G V Dha N Dha D M V R P Y E H M Y G L Cys R P P K H G Cys D

#### antiSMASH-DB 4.0 matches for allorf_80770_81003

100.0%
NZ_CP046514.1 and 5 others:
NZ_CP069278.1 Lanthipeptides: allorf_1053415_1053648_lanthipeptide NZ_JADMSA010000006.1 Lanthipeptides: allorf_028329_028562_lanthipeptide NZ_JADMUN010000007.1 Lanthipeptides: allorf_096455_096688_lanthipeptide NZ_JADNBL010000011.1 Lanthipeptides: allorf_80770_81003_lanthipeptide NZ_JAHTKJ010000004.1 Lanthipeptides: allorf_006104_006337_lanthipeptide
Lanthipeptides: allorf_1955325_1955558_lanthipeptide
1
R L A V F I S N R R R S P D I K Y G C V S M L P L C G D V S G V S N S D M V R P Y E H M Y G L C R P P K H G C D
56
R L A V F I S N R R R S P D I K Y G C V S M L P L C G D V S G V S N S D M V R P Y E H M Y G L C R P P K H G C D
1
R L A V F I S N R R R S P D I K Y G C V S M L P L C G D V S G V S N S D M V R P Y E H M Y G L C R P P K H G C D
56
23.2%
NZ_LT907978.1:
Lanthipeptides: allorf_2780940_2781146_lanthipeptide
4
V F I S N R R R S P D I K Y G C V S M L P L C G D V S G V S N S D M V R P Y E H M Y G L
47
V F+ N R + + Y L D V S +S++++V R Y +++ +
14
V F V R N R N K K S E C L Y------L L S T D V S-L S D A E I V R I Y G N I W Q V
50
17.9%
NZ_GG657757.1 and 1 other:
NZ_GG657757.1 Lanthipeptides: allorf_4699229_4699420_lanthipeptide
Lanthipeptides: allorf_4699229_4699420_lanthipeptide
11
R S P D I K Y G C V S M L P L C G D V S
30
R S P Y G + L P L V S
10
R S P A H T Y G N L R W L P L L R Q V S
29
with 3 more sequence matches
14.3%
NZ_CP059991.1:
Lanthipeptides: allorf_7879265_7879423_lanthipeptide
13
P D I K Y G C V S M L P L C G D V S
30
P D K V + L C G +S
4
P D S K I N S V Q I C T L C G K L S
21
12.5%
NZ_KB235904.1:
Lanthipeptides: OSCIL6407_RS32785_lanthipeptide
9
R R R S P D I K Y G C V S M L P L C G D V S G V S N S D
36
R+R+ + + C++ + L G + G++ D
23
R K R A T S L F H F C L T A I A L L G I L I G L A F I D
50
10.7%
NZ_CP017599.1 and 1 other:
NZ_CP017599.1 Lanthipeptides: BJP34_RS13245_lanthipeptide
Lanthipeptides: BJP34_RS13245_lanthipeptide
24
P L C G D V S G V S N S D M V R P Y E H
43
P C + G V ++ +V + H
14
P T C V N T G G V G S T T I V V I F N H
33

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.60 out of 27.78
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46
Confidence: medium
Additional weak hits (1):
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

I2A13_RS07655 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 2913.5 Da
  Molecular weight: 2915.4 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2933.4 Da N = 1
    2951.4 Da N = 2
    2969.4 Da N = 3
    2987.4 Da N = 4
    3005.5 Da N = 5
    3023.5 Da N = 6
    3041.5 Da N = 7
allorf_61109_61330 - Class II
  Cleavage pHMM score: -4.90
  RODEO score: 0
  Monoisotopic mass: 6346.3 Da
  Molecular weight: 6350.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6368.1 Da N = 1
    6386.1 Da N = 2
    6404.1 Da N = 3
    6422.1 Da N = 4
    6440.2 Da N = 5
    6458.2 Da N = 6
    6476.2 Da N = 7
allorf_62374_62448 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 799.3 Da
  Molecular weight: 799.8 Da
  Number of bridges: 1
allorf_64006_64134 - Class II
  Cleavage pHMM score: -2.10
  RODEO score: 0
  Monoisotopic mass: 2909.6 Da
  Molecular weight: 2911.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2929.3 Da N = 1
    2947.3 Da N = 2
    2965.4 Da N = 3
    2983.4 Da N = 4
    3001.4 Da N = 5
allorf_64040_64156 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 3556.1 Da
  Molecular weight: 3558.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3576.3 Da N = 1
    3594.3 Da N = 2
    3612.3 Da N = 3
    3630.3 Da N = 4
allorf_79901_80134 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 4733.8 Da
  Molecular weight: 4736.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4754.8 Da N = 1
    4772.8 Da N = 2
allorf_80770_81003 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 6173.0 Da
  Molecular weight: 6177.1 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6195.1 Da N = 1
    6213.2 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN | Regulator of nitrogen assimilation and virulence

NZ_JADNBL010000006.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 61,797 - 82,879 nt. (total: 21,083 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acyltransferase kinase
I2A13_RS05450: acyltransferase

smcogs
  SMCOG1141: acyltransferase

I2A13_RS05485: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Ligases: synthetase
I2A13_RS05460: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4 |  | 0.36 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.35 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000644.3 |  | 0.34 | terpene | carotenoid | Dietzia sp. CQ4
BGC0001227.3 |  | 0.34 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.34 | terpene | carotenoid | Myxococcus xanthus
BGC0000633.3 |  | 0.34 | terpene | carotenoid | Streptomyces avermitilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4 |  | 0.36 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.35 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000644.3 |  | 0.34 | terpene | carotenoid | Dietzia sp. CQ4
BGC0001227.3 |  | 0.34 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.34 | terpene | carotenoid | Myxococcus xanthus
BGC0000633.3 |  | 0.34 | terpene | carotenoid | Streptomyces avermitilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
I2A13_RS05460: PT_FPPS_like
Domain 1 (48 - 350): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72
Confidence: medium
Additional weak hits (7):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.61 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.86 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.94 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.10 out of 26.06
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.41 out of 33.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.19 out of 26.06
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.71 out of 29.65
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C