LOCUS       NZ_CP043317            10399 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces olivaceus strain SCSIO T05 chromosome, complete genome.
ACCESSION   NZ_CP043317
VERSION     NZ_CP043317.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivaceus
  ORGANISM  Streptomyces olivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated
            Production of Lobophorin CR4 via Metabolic Engineering and Genome
            Mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2019) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Science, NO.164 Xingang Road, Guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-MAR-2017
            Assembly Method                   :: HGAP v. MAR-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 8458055.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015244315.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:39:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,352
            CDSs (total)                      :: 7,265
            Genes (coding)                    :: 7,077
            CDSs (with protein)               :: 7,077
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 188
            CDSs (without protein)            :: 188
            Pseudo Genes (ambiguous residues) :: 0 of 188
            Pseudo Genes (frameshifted)       :: 106 of 188
            Pseudo Genes (incomplete)         :: 98 of 188
            Pseudo Genes (internal stop)      :: 7 of 188
            Pseudo Genes (multiple problems)  :: 23 of 188
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:52:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6667384
            Orig. end                         :: 6677783
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP043317.1.
            Bacteria and source DNA available from South China Sea Institute of
            Oceanology, Chinese Academy of Science; 164 West Xingang Road,
            Guangzhou 510301, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="31"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5399)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    687..702
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.08"
                     /tool="antismash"
     misc_feature    891..906
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            1478..1981
                     /db_xref="GeneID:69764120"
                     /locus_tag="FYC74_RS28750"
     CDS             1478..1981
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /db_xref="GeneID:69764120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329308.1"
                     /locus_tag="FYC74_RS28750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_194278189.1"
                     /transl_table=11
                     /translation="MIDERATGRRVIRTVLPAEAGTLAALHHRARSTYYPDGLPEDGTD
                     WAAVWRTAVERPDGHVLCAVEHGRIVALASFRVPEGGGRDTVKLFQFHVDPGHWRSGIG
                     TALHTACVEQWRADGHRDAVLDVHVDNKRAQAFYARLGWLPDPHNPPAEGDHHLFLRFD
                     VLGE"
     gene            2057..2770
                     /db_xref="GeneID:69764121"
                     /locus_tag="FYC74_RS28755"
     CDS             2057..2770
                     /codon_start=1
                     /db_xref="GeneID:69764121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067467.1"
                     /locus_tag="FYC74_RS28755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_194278190.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHRDGVEVVHRSFELDP
                     GRAKDDVQPVLTMLTAKYGMSEAQAQAGEDNLGAQATAEGLDYRTRDRDHGSTFDMHRL
                     LHLAKERNLHAELLDAFYRGNFADERSVFNDDERLVELSVAAGLDADEVRAVLADPAAH
                     ADAVRADEREAAQLGATGVPFFVLDRAYGVSGAQPAEVFTQALTQAWGERTPLKLIDDG
                     DAEACGPDGCAVPRS"
     gene            2846..3940
                     /db_xref="GeneID:69764122"
                     /locus_tag="FYC74_RS28760"
     CDS             2846..3940
                     /NRPS_PKS="Domain: Aminotran_5 (28-358). E-value: 4.2e-25.
                     Score: 80.3. Matches aSDomain:
                     nrpspksdomains_FYC74_RS28760_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:69764122"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448151.1"
                     /locus_tag="FYC74_RS28760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_194278191.1"
                     /sec_met_domain="Aminotran_5 (E-value: 3.3e-19, bitscore:
                     67.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGEVPGPHSGAMESFENLVRAEFAPKTTYLNTASTGLLPARTLV
                     AMRDAAARAAEGQPLDMFADVEAARAAYARLMGVPATRVATGSSVATFSGLVAASLPEG
                     AEVLTAEADFASLVNPLYTRGGLKVRSVPLDRLAESVGPDTALVAVSSVQSADGRLADL
                     PALRDAARAHGARTLIDVSQSNGWLPTAADDFDYVAAVAYKWVLCPRGVAFLVVPEDLG
                     AAAGLRPLFAGWASGEHPWDSCYGPVEELAHSARRFDESPALFSYTGARQSLDLIGELG
                     VDAVHAHDTGLADRFRAGVRSLGHEPVPAPGSAIVSVPGLGHRQGVLSSAGVQVSDRAG
                     NLRAAFHVYNTAADVDRLLDVLAG"
     aSDomain        2930..3919
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FYC74_RS28760_Aminotran_5.1"
                     /evalue="4.20E-25"
                     /label="FYC74_RS28760_Aminotran_5.1"
                     /locus_tag="FYC74_RS28760"
                     /protein_end="358"
                     /protein_start="28"
                     /score="80.3"
                     /tool="antismash"
                     /translation="TYLNTASTGLLPARTLVAMRDAAARAAEGQPLDMFADVEAARAAY
                     ARLMGVPATRVATGSSVATFSGLVAASLPEGAEVLTAEADFASLVNPLYTRGGLKVRSV
                     PLDRLAESVGPDTALVAVSSVQSADGRLADLPALRDAARAHGARTLIDVSQSNGWLPTA
                     ADDFDYVAAVAYKWVLCPRGVAFLVVPEDLGAAAGLRPLFAGWASGEHPWDSCYGPVEE
                     LAHSARRFDESPALFSYTGARQSLDLIGELGVDAVHAHDTGLADRFRAGVRSLGHEPVP
                     APGSAIVSVPGLGHRQGVLSSAGVQVSDRAGNLRAAFHVYNTAADVDRL"
     gene            complement(4098..4994)
                     /db_xref="GeneID:69764123"
                     /gene="thpD"
                     /locus_tag="FYC74_RS28765"
     CDS             complement(4098..4994)
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69764123"
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448161.1"
                     /locus_tag="FYC74_RS28765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_194278192.1"
                     /sec_met_domain="PhyH (E-value: 1.1e-40, bitscore: 138.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTNVTDLYPTRGATEVATPRQDPVVWGSPDTPGPVSQGDLQA
                     LDRDGFLAIDQLIGPDEVEVYQRELERLTTDPAIREDERSIVEPQSKEIRSVFEVHRIS
                     EVFAKLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLAN
                     MRTISVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGIPSDEAL
                     TKMASEYGVKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFSA
                     PIRRPEFIGARDFTPVR"
     misc_feature    complement(4985..5005)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            complement(5001..5399)
                     /db_xref="GeneID:69764124"
                     /locus_tag="FYC74_RS28770"
     CDS             complement(5001..5399)
                     /codon_start=1
                     /db_xref="GeneID:69764124"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037840.1"
                     /locus_tag="FYC74_RS28770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_037770517.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.6e-52, bitscore:
                     174.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKELEGTDRHVKSASGTWETKRIVLAKEKVGFSLHETILY
                     AGMETEMWYANHIEAVVCTKGDAELTDRETGKKYHITPGTMYLLNGHERHTLKVNEEFH
                     CICVFNPPVTGREDHDENGVYPLLTEEV"
     gene            complement(5501..6772)
                     /db_xref="GeneID:69764125"
                     /gene="ectB"
                     /locus_tag="FYC74_RS28775"
     CDS             complement(5501..6772)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (29-366). E-value: 6.1e-72.
                     Score: 234.4. Matches aSDomain:
                     nrpspksdomains_FYC74_RS28775_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GeneID:69764125"
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="FYC74_RS28775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_031046586.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.3e-77, bitscore:
                     258.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRALGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNAVLKRALIDYLERDGVTHGLDMSTTAKRRFLETFQNIILRKRD
                     LPYKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVEDFMWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARV
                     EWLRALADLCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGMPMA
                     LTLFKPELDVWEPGEHNGTFRGNNPAFVTATATLETYWADGSAMEKQTRKRGEQVEQHM
                     IAITEENLADIKEYRGRGLVWGLEFHDKDRAGRVAKRAFELGLLIETSGPESEVVKLLP
                     ALTITPEELDEGMKTLARAVRETA"
     aSDomain        complement(5675..6685)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FYC74_RS28775_Aminotran_3.1"
                     /evalue="6.10E-72"
                     /label="FYC74_RS28775_Aminotran_3.1"
                     /locus_tag="FYC74_RS28775"
                     /protein_end="366"
                     /protein_start="29"
                     /score="234.4"
                     /tool="antismash"
                     /translation="DRALGSRMYDEDGHEYLDFFAGAGSLNYGHNNAVLKRALIDYLER
                     DGVTHGLDMSTTAKRRFLETFQNIILRKRDLPYKVMFPGPTGTNAVEAALKLARKVKGR
                     ESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVEDFMWFERL
                     LEDQGSGLNKPAAVIVETVQGEGGINVARVEWLRALADLCERQDMLLIVDDIQMGCGRT
                     GAFFSFEEAGITPDIVTVSKSISGYGMPMALTLFKPELDVWEPGEHNGTFRGNNPAFVT
                     ATATLETYWADGSAMEKQTRKRGEQVEQHMIAITEENLADIKEYRGRGLVWGLEFH"
     gene            complement(6904..7416)
                     /db_xref="GeneID:69764126"
                     /gene="ectA"
                     /locus_tag="FYC74_RS28780"
     CDS             complement(6904..7416)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69764126"
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448158.1"
                     /locus_tag="FYC74_RS28780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_194278193.1"
                     /transl_table=11
                     /translation="MTAAQADLQIDRPRVADGAALWRIARDSKVLDLNSSYSYLLWCRD
                     FAATSAVARDGHGVPVGFITGYVRPDRPDTLLVWQVAVDEAHRGRRLAASMLDGLAART
                     VTELGLTTLETTVSPDNTASQRLFASFAERHGARLEREVLFDTGLFPDGPHQPEVLHRI
                     GPLSAAG"
     misc_feature    7426..7441
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     misc_feature    complement(7441..7453)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    complement(7510..7526)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.88"
                     /tool="antismash"
     misc_feature    complement(7572..7587)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    7582..7597
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(7582..7599)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.57"
                     /tool="antismash"
     misc_feature    7656..7672
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.39"
                     /tool="antismash"
     misc_feature    7702..7715
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.14"
                     /tool="antismash"
     gene            complement(7746..8875)
                     /db_xref="GeneID:69764127"
                     /locus_tag="FYC74_RS28785"
                     /pseudo=""
     CDS             complement(7746..8875)
                     /NRPS_PKS="Domain: Aminotran_5 (52-281). E-value: 8.5e-29.
                     Score: 92.5. Matches aSDomain:
                     nrpspksdomains_FYC74_RS28785_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:69764127"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976957.1"
                     /locus_tag="FYC74_RS28785"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="pyridoxal-phosphate-dependent aminotransferase
                     family protein"
                     /pseudo=""
                     /sec_met_domain="Aminotran_5 (E-value: 7.4e-22, bitscore:
                     76.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLAPLGAGRFAAIEDRVARLLGTGQDVVVMQGEALLPLE
                     GAIRAAAGPGTVALNVVTGPYGQTFGDWLRDCGATVHDLAVPFHTAVSAGQVREALAAH
                     PETDFVSLVHAEAATGNTNPVGEIGEVVRAHGALFYLDAVASVGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWIDGGRKALLHAP
                     AQLEMLALEACVERIEAEGPETVMARHAAAAAATRAGALALGGLEPYVYEAKDAAPVAT
                     TLRTPPRTSTPRHW"
     aSDomain        complement(8033..8719)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FYC74_RS28785_Aminotran_5.1"
                     /evalue="8.50E-29"
                     /label="FYC74_RS28785_Aminotran_5.1"
                     /locus_tag="FYC74_RS28785"
                     /protein_end="281"
                     /protein_start="52"
                     /score="92.5"
                     /tool="antismash"
                     /translation="GPGTVALNVVTGPYGQTFGDWLRDCGATVHDLAVPFHTAVSAGQV
                     REALAAHPETDFVSLVHAEAATGNTNPVGEIGEVVRAHGALFYLDAVASVGAEPVLPDA
                     WGVDLCVIGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWIDGGR
                     KALLHAPAQLEMLALEACVERIEAEGPETVMARHAAAAAATRAGALALGGLEPYVYEAK
                     DAAPVAT"
     gene            9080..10171
                     /db_xref="GeneID:69764128"
                     /locus_tag="FYC74_RS28790"
     CDS             9080..10171
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69764128"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989359.1"
                     /locus_tag="FYC74_RS28790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_194278194.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 9.8e-18, bitscore:
                     63.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRAVLHVKGRVLVGPEEVRDEVWVIDGRISYDRPAGAADVRTV
                     EGWALPGLVDAHCHVGLDRHGAVPADAAEKQALSDREAGTLLLRDAGSPSDTRWIDDRD
                     DLPKIIRAGRHIARTRRYIRNYAWEVEPDDLVAYVAQEARRGDGWVKLVGDWIDRDLGD
                     LSACWPRGAVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTDDTIPLF
                     AERGVAIVPTLVNIATFPALADGGESRFPRWSAHMRRLHERRYDTVRNAYDAGIPVFVG
                     TDAGGALAHGLAGAEVAELVTAGIPPVEALSATTWAARRWLGRPGLDEGAPADLVVFDR
                     DPRADVRVLTDPRRVVLNGRVVG"
ORIGIN
        1 ggtggaggtc gccgacgcgg agaccgcgct cggcccggtc cgcctcaccg gcgaactcgc
       61 ccgcaccagc taccaactgc gggccttcgc cgacatcgtc gacgagggcg agttcctcgg
      121 cgtggtcgtc aaccaccccg acgacaccgc caccccgccc atcccggacc tgcgccgcta
      181 caaggtgccg ctcggcgtcg tcgccgtcta ctcggcgtcc aacttcccct tcgccttctc
      241 ggtccccggc ggcgacaccg cgagcgccct cgcggccggc tgcccggtcg tcgtcaaggc
      301 ccaccccgac cacccggccc tgtccgagct ggtcgccaag gtgctgcgcc gcgccgccgc
      361 ccggcacggc gtccccgagg gcgtcgtcgg cctcgtccac ggcttcgagg cgggcgtcga
      421 gctggtcaag cacccgctgg tcgcggcggc gggcttcacc gggtccgtac gcgggggccg
      481 cgcgctcttc gacgcggcgg cggcacggcc ggtgccgatc cccttccacg gcgagctggg
      541 ctcgctgaac ccggtcgtcg tcaccgaggc cgccgccgcc gagcgggcgg acgcgatcgg
      601 tgcggggctg gccggttcga tgaccctggg cgtcggccag ttctgcgtca agcccggcct
      661 ggtcctcgtg cccgcgggcg ccgccggtga cgggctggtc aagaccctca cggacgcggt
      721 cagcgacacc gacgccggtg tcctcctcga ccaccgcatg cgggacaact tcgtggccgg
      781 cgtcgccgag cgggtggcgc tgcccgacgt ggactcgccg gtgacgcccg gctcgggcgg
      841 cgagcacacc gtcgccgccg ggttcctcac cgtgccggcc gcgcggctgg ccgccgaggg
      901 cgagcacgac ctgctcctgg aggagtgctt cgggccggtc accgtcgtgg tccgctacca
      961 ggacgccgag gaggtgcggg ccgtgctctc ccggctgccg ggcaacctca cggcgaccgt
     1021 gcagatctcc gccggggaag cggcggggga ggggcgcggg gccgaggtcc tcgccgaggt
     1081 gacgccgctg gccgggcggg tgctggtgaa cggctggccg acgggggtcg ccgtggcggc
     1141 ggcccagcac cacggggggc cgtacccggc gaccacgtcg acgtccacgt cggtgggcgg
     1201 cacggcgatc gagcggtggc tgcggccggt ggcctaccag ggggtgccgg aggcgctgct
     1261 gccgcccgag gtgcgggacg ggaaccccct cgggctgccg cggcggttca acggggtgct
     1321 ggagcggtag cggttcgcgg tcgcgccgta ggggcgcggt ggtactgcgg ccgactcgcc
     1381 gtcgtggcct gtcgcgcagt tccccgcgcc cctggggcga tttcccccac cgggactgcg
     1441 cgcaaccgcg cggccgggct cgcgcgtcct ggtgtgcatg atcgatgaac gtgcgaccgg
     1501 gcgccgggtg atccgtaccg tgctgcccgc cgaggccggg accctcgccg cgctgcacca
     1561 ccgggcgcgg tcgacgtact acccggacgg gctgcccgag gacggtaccg actgggcggc
     1621 cgtgtggcgc accgccgtcg agcgccccga cggacacgtg ctgtgcgccg tggagcacgg
     1681 gcgcatcgtc gccctcgcct ccttccgggt gccggaggga ggcgggcgcg acaccgtcaa
     1741 gctcttccag ttccacgtcg accccggcca ctggcgctcc ggcatcggca ccgccctgca
     1801 cacggcctgc gtcgagcagt ggcgggccga cggccaccgg gacgcggtcc tggacgtgca
     1861 cgtggacaac aagcgtgccc aggccttcta cgcccgcctc ggctggctcc ccgacccgca
     1921 caacccgccc gcggagggcg accaccacct cttcctgcgg ttcgacgtgc tcggggaatg
     1981 agaccggctg cttgaacgtt cacgcacgag gcggggaggg cctccgcagc ggtacgacct
     2041 ggagaagagc cgagacatgc gcgtcgagat ctggagcgac atcgcctgcc cgtggtgcta
     2101 cgtgggcaag gcccgcttcg agaaggcgct cgcggccttc ccgcaccggg acggcgtcga
     2161 ggtggtccac cggtccttcg agctggaccc cggccgggcc aaggacgacg tgcagccggt
     2221 actgacgatg ctcaccgcca agtacggcat gagcgaggcg caggcgcagg ccggtgagga
     2281 caacctcggc gcgcaggcca ccgccgaggg ccttgactac cgcacccggg accgcgacca
     2341 cggcagcacc ttcgacatgc accggctgct gcacctggcc aaggagcgga acctgcacgc
     2401 ggaactgctg gacgccttct accggggcaa cttcgccgac gagcgctccg tgttcaacga
     2461 cgacgagcgg ctcgtggagc tgtccgtcgc cgccggactc gacgcggacg aggtccgcgc
     2521 ggtgctcgcc gaccccgccg cccacgccga cgcggtgcgc gccgacgagc gcgaggccgc
     2581 gcagctcggg gccaccggcg tgccgttctt cgtgctcgac cgggcctacg gcgtctccgg
     2641 cgcccagccc gccgaggtct tcacgcaggc gctgacgcag gcctggggcg agcggacgcc
     2701 gctcaagctg atcgacgacg gggacgcgga ggcctgcggc cccgacgggt gtgcggtgcc
     2761 ccggagctga gggccccgcc cctcggaacc gcaggtcggc ggccgtgcat aagcgttgct
     2821 tggggaaacc gctaagaaat acgcaatgga cggggaggtc ccgggaccgc acagtggtgc
     2881 catggagagc ttcgagaacc tcgtccgcgc cgagttcgcc ccgaagacca cgtacctgaa
     2941 caccgccagt accggcctgc tgcccgcccg gaccctcgtc gccatgcgtg acgcggcggc
     3001 ccgtgcggcc gaggggcagc cgctcgacat gttcgccgac gtcgaggcgg cccgggccgc
     3061 gtacgcccgc ctcatggggg tgcccgccac ccgggtcgcg accggctcgt cggtcgccac
     3121 gttcagcggg ctcgtcgccg cctcgctgcc cgagggcgcc gaggtcctca ccgccgaggc
     3181 cgacttcgcc tcgctggtga accccctgta cacgcgcggc ggcctgaagg tgcgcagtgt
     3241 gccgctggat cggctcgccg agtcggtggg cccggacacc gcgctcgtcg cggtcagctc
     3301 cgtgcagtcg gccgacgggc ggctcgccga cctgcccgcg ctgcgggacg ccgcccgcgc
     3361 gcacggggcg cggaccctga tcgacgtgtc ccagtcgaac ggctggctgc cgacggccgc
     3421 ggacgacttc gactacgtcg ccgccgtcgc ctacaagtgg gtgctctgcc cgcgcggcgt
     3481 cgccttcctc gtcgtaccgg aggatctggg agcggcggcc gggctgcggc cgctgttcgc
     3541 cgggtgggcg tcgggcgagc acccctggga cagctgctac ggccccgtcg aggaactcgc
     3601 gcactccgcc cggcgcttcg acgagagccc cgccctgttc tcgtacaccg gcgcccggca
     3661 gtccctggac ctgatcgggg aactgggcgt cgacgccgtg cacgcccacg acaccggtct
     3721 cgccgaccgc ttccgcgcgg gggtgcgctc gctgggccac gagccggtgc ccgcgccggg
     3781 ttccgcgatc gtgtccgtgc cggggctcgg ccaccggcag ggcgtgctga gcagcgccgg
     3841 cgtccaggtg tccgaccggg cgggcaacct gcgggccgcc ttccacgtgt acaacaccgc
     3901 ggccgacgtg gaccggctcc tcgacgtact ggcaggctga gggaagagcc ccggaacagc
     3961 atcgggcagg agcctcccgt cccacacgaa gaggcccctg cccgagatca gatgcggctc
     4021 acttcaccgg agtgaagtcc cgcgccccga tgctgcgaca tccgggggac aacccccgga
     4081 cccccggccg agccgggtca ccggacggga gtgaagtccc gcgccccaat gaactccggt
     4141 cgcctgatcg gcgccgagaa cggctcgacc gccgtgttct ccacgctgtt gaacacgatg
     4201 aacacgttgc tgcgcgggaa cggcgtgatg ttgtcgcccg aaccgtgcat gcagttgcag
     4261 tcgaaccagg tcgccgagcc ggccttgccg gtgaacagct tgacgccgta ctccgacgcc
     4321 atcttcgtca gcgcctcgtc ggacgggatc cccgcgtcct gcatctgcag cgacttcttg
     4381 tagttgtcct tcggcgtggc ccccgcgcac ccgaggaacg tcttgtgcga ccccggcatg
     4441 atcatgagac cgccgttggt gtcgtagttc tcggtgagtg cgatcgagac cgagatcgta
     4501 cgcatgttcg ccaggccgtc ctcggcgtgc caggtctcga agtccgagtg ccagtagaag
     4561 ccgctggctc cgaagcccgg cttgacgttg atccgcgact ggtggacgta gacgtccgag
     4621 ccgaggatct gccgggcccg cccgaccacg cgctcgtcgc gcacaagttt cgcgaagacc
     4681 tcgctgatcc tgtgcacctc gaagaccgac cggatctcct tggactgcgg ctcgacgatc
     4741 gagcgctcgt cctcgcggat ggccgggtcg gtggtgagcc gctccagctc ccgctggtag
     4801 acctcgacct cgtccggccc gatgagctgg tcgatggcga ggaacccgtc gcggtccagg
     4861 gcctggaggt cgccctggga gacgggaccg ggtgtgtccg gggagcccca gaccaccggg
     4921 tcctgccgtg gggttgccac ctcggtggcg ccgcgggtgg gatagaggtc agtgacgttc
     4981 gtggtcgtgg tcacggtgac tcacacctcc tcggtgagca gcgggtagac gccgttctcg
     5041 tcgtggtcct cccgtccggt cacgggggga ttgaagacgc agatgcagtg gaactcctcg
     5101 ttgaccttga gcgtgtgccg ctcatggccg ttcaggaggt acatggtgcc gggcgtgatg
     5161 tggtacttct tccccgtttc gcggtcggtc aattccgcgt cgcccttcgt gcagacgacg
     5221 gcctcgatgt ggttcgcgta ccacatctcg gtctccatac ccgcgtacag gatcgtctcg
     5281 tgcagggaga agccgacctt ctccttggcg aggacgatgc gcttggtctc ccaggtcccc
     5341 gacgccgact tcacgtggcg gtcggtgcct tccagttcct tgaacgaacg gacgatcacg
     5401 gtgttgcgat gcctcctagg tgaagggtgt gccatggtcc ccggcgcccc gggccgcgag
     5461 gcccgaggcg ccggaagcag ggagggcggt gccggagcgg tcaggccgtc tcgcgcacgg
     5521 cccgggcgag ggtcttcatg ccctcgtcca gctcttcggg cgtgatggtg agcgccggca
     5581 ggagtttgac gacctcgctc tcggggccgg acgtctcgat gagcagcccg agctcgaagg
     5641 cgcgtttggc gacccggccc gcgcggtcct tgtcgtggaa ctccaggccc cagaccaggc
     5701 cgcggccccg gtactccttg atgtccgcga ggttctcctc ggtgatggcg atcatgtgct
     5761 gctcgacctg ctcaccgcgc ttgcgggtct gcttctccat cgccgagccg tcggcccagt
     5821 acgtctccag cgtggcggtc gccgtgacga aggccgggtt gttgccgcgg aaggtgccgt
     5881 tgtgctcacc cggctcccag acgtccagct cgggcttgaa cagggtcagc gccatcggca
     5941 tgccgtagcc gctgatcgac ttggagacgg tgacgatgtc cggcgtgatg cccgcttcct
     6001 cgaaggagaa gaaggcgccg gtacggccgc agcccatctg gatgtcgtcc acgatgagca
     6061 gcatgtcctg gcgctcgcac aggtcggcca gggcgcgcag ccactcgacg cgggcgacgt
     6121 tgatgccgcc ctcgccctgc acggtctcca cgatcacggc ggccggcttg ttcagaccgg
     6181 agccctggtc ctcgagcagc cgctcgaacc acatgaagtc ctcgacggtc ccgtcgaagt
     6241 agttgtcgaa cggcatgggc gtgccgtgca ccagcgggat gccggcgccg gcccgcttga
     6301 acgcgttgcc ggtcacggcc agcgagccca gcgacatgcc gtggaaggcg ttggtgaagg
     6361 acacgatcga ctcgcggccc ttgaccttgc gcgccagctt cagcgcggcc tcgacggcgt
     6421 tggtgcccgt cgggcccggg aacatgacct tgtacggcag gtcgcgcttg cgcaggatga
     6481 tgttctggaa cgtctccagg aagcggcgct tggcggtggt cgacatgtcg agcccgtgcg
     6541 tgacgccgtc ccgctccagg tagtcgatca gcgcgcgttt caggacggcg ttgttgtgcc
     6601 cgtagttgag cgaacccgct ccggcgaaga agtcgaggta ctcgtggccg tcctcgtcgt
     6661 acatgcggct gccgagcgca cggtcgaaga cggtgggcca gccgcggcag tagctgcgca
     6721 cctcggactc gacggtctcg aagacgctga ggtcgggctg ggtgatggtc acgacgaatc
     6781 gctcctcgtt gggtgagggt gtcagaggaa ggtcgtacgg tccggcggaa ccggtgcggt
     6841 cccggccggg aagtctgagg ggccggactg ccgggggtgc ccggcgtccg ggcggccggc
     6901 gggtcagccg gccgcggaca gggggccgat gcggtggagg acctctggtt ggtgcggccc
     6961 gtccgggaac aggccggtgt cgaagagcac ctcgcgttcc agccgggcac cgtgccgctc
     7021 ggcgaacgag gcgaacagtc gctgggacgc cgtgttgtcg ggggagacgg tggtctcgag
     7081 ggtggtcagc ccgagctccg tcacggtccg ggcggcgagc ccgtcgagca tcgaggcggc
     7141 gagccggcgc ccgcggtgcg cctcgtccac cgccacctgc cagaccagca gggtgtccgg
     7201 ccggtccggg cggacgtagc cggtgatgaa gccgaccggc acgccgtgcc cgtcacgggc
     7261 gacggccgac gtggcggcga agtcccggca ccagagcaga tagctgtagg acgagttcag
     7321 gtcgaggacc ttggaatccc tcgctatgcg ccacagggcg gcgccgtcgg ccactctcgg
     7381 acgatcgatt tgcaggtctg cttgcgcggc agtcatgtaa atcgaattta cccagggaaa
     7441 ttggaaattg catcgcggga cggggttacg gatgcaggcg tcctgtgtta tcacgcgggc
     7501 gcgtgccacc gcgcgagaag tgtgcgcaat gtggcgattt gtaccggtca aaaggtgcga
     7561 agcgggccgc atgtggatcg ggtcacaatc gcgtaaccga tgcgagacgt gtccgaaatg
     7621 cgagaatcga ggttcgcgga atctttgtgt ttaggtcaag agaaagcggg cagaagaata
     7681 tgggaacctg tgctgatcca tattctttaa ttcagtttgt gtgtagttcg ggaattcccg
     7741 ggaattcagt ctcccgaaag aaccgccccg ccctgtccgt cccatgcccg gtccgccgcc
     7801 cgccgggcgg cctccggatc ggccttgagg cccttctccg ccagcgcggc acccagtgcc
     7861 gccaggcagc cgtgcaccgc cccgcgcgtg gcgtcccggc cgtagtggtt cacccggatc
     7921 atctccccgg ccagcgcacc tccgccggcg gccagcggca gtgccggatc cgactccagg
     7981 gcccgggtca ccagtgccga ggcgtcgacg tccggggggg ggtccgcagc gtcgtcgcga
     8041 ccggcgccgc gtccttcgcc tcgtacacgt acggctccag gccgcccagg gcgagcgcgc
     8101 cggcccgggt ggccgccgcg gccgccgcgt gccgcgccat caccgtctcc gggccctccg
     8161 cctcgatacg ctccacgcag gcctccagtg cgagcatctc caactgggcc ggcgcgtgca
     8221 gcagcgcttt tcggccaccg tcgatccagc gctccttcca gtcgaggagg gagaggtagg
     8281 accggcgcgg ggcgcccggg ttcgccgcca tccgcgccca cgcccgctcg ctgaccgaca
     8341 ccgccgacac cccggccggg ccgcccatcg ccttctgcgc gccgatgacg cacaggtcca
     8401 cgccccacgc gtccggcagc accggctcgg cgccgacgga ggccacggcg tccaggtaga
     8461 acaacgcgcc gtgcgcccgc accacctcac cgatctcccc gaccgggttg gtgttcccgg
     8521 tcgccgcctc ggcgtgcacc agggacacga agtcggtctc cgggtgcgcg gcgagcgcct
     8581 cccgcacctg cccggcgctc acagccgtgt ggaacggcac ggcgaggtcg tgcacggtcg
     8641 ccccgcagtc ccgcagccag tcgccgaacg tctgcccgta ggggccggtg acgacgttca
     8701 gcgcgacggt gcccggaccg gcggcggcgc ggatcgcgcc ctccagcggc agcagcgcct
     8761 cgccctgcat gaccacgacg tcctgcccgg tgccgagcag ccgcgcgacc cggtcctcga
     8821 tcgcggcgaa acggccggcg cccagcggtg cgaggtccag gaacgggtgg gtcatgcggg
     8881 gctctcttca ctcacgggca ggtggacgac acgtagtgga acgagagtaa ccacggccca
     8941 ggccggcact cacgccggag cccttccgtt gcgacacccc cacgcccgga atcgtagctt
     9001 ccgctacggc cggaacggcc ccgggccgag ggccggcggc ccgcccggac gcctgtacgg
     9061 gcaccgttag ggtgcgggca tgactgatcg cgcggtgctg cacgtgaagg ggcgggtgct
     9121 cgtcgggccc gaggaggtcc gggacgaggt gtgggtgatc gacgggcgga tctcctacga
     9181 ccgccccgcc ggcgccgccg acgtgcgcac cgtcgagggg tgggcgctgc ccggcctggt
     9241 cgacgcgcac tgccacgtcg gcctcgaccg gcacggcgcg gtcccggcgg acgccgccga
     9301 gaagcaggcc ctgtccgacc gcgaggcggg caccctgctc ctccgcgacg cgggctcgcc
     9361 ctccgacacc cgctggatcg acgaccgcga cgacctgccg aagatcatcc gggccggccg
     9421 gcacatcgcc cgcacccgcc gctacatccg caactacgcc tgggaggtcg agcccgacga
     9481 cctcgtcgcg tacgtcgccc aggaggcccg gcgcggcgac ggctgggtga agctggtcgg
     9541 cgactggatc gaccgcgacc tcggcgacct gtccgcgtgc tggccgcgcg gcgccgtgga
     9601 ggcggccatc gccgaggccc accgcctggg cgcccgggtc accgcgcact gcttcgccga
     9661 ggactccctg cgcgacctgg tcgaggccgg gatcgactgc gtcgaacacg ccacggggct
     9721 gaccgacgac accatcccgc tcttcgccga gcgcggcgtc gccatcgtgc cgaccctcgt
     9781 caacatcgcc accttccccg cgctggccga cggcggcgag tcccgcttcc cgcgctggtc
     9841 ggcccacatg cgccggctgc acgaacgccg ctacgacacc gtccgcaacg cctacgacgc
     9901 cgggatcccg gtcttcgtcg gcaccgacgc cggaggcgcc ctcgcccacg gtctggcggg
     9961 cgcggaggtc gcggagctgg tcaccgccgg catcccgccc gtcgaggcgc tctccgccac
    10021 gacctgggcc gcccggcgct ggctcgggcg ccccggcctg gacgagggcg cgccggcgga
    10081 cctggtggtg ttcgaccggg acccgcgcgc cgacgtgcgc gtgctcaccg atccgcgccg
    10141 ggtggtgctg aacgggcggg tcgtcggcta gccgatgcga gtgacctgag ggaacgcgcg
    10201 tgccgcgaga ttcgaaagga tgcgccaaaa ccccacgaag gggtgaagtg acctcggatc
    10261 gctgacggtg gggcgtacgc ggggagattc tttccgggtc ccaagcacgt cgctcatgtg
    10321 tgtcccacac gcatgtctca ctgggggtcc caccaccttg aacggcaaca ccttccgcat
    10381 gcccgcacgc cgcctcgcc
//
