LOCUS       NZ_CP043317            10627 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces olivaceus strain SCSIO T05 chromosome, complete genome.
ACCESSION   NZ_CP043317
VERSION     NZ_CP043317.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivaceus
  ORGANISM  Streptomyces olivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated
            Production of Lobophorin CR4 via Metabolic Engineering and Genome
            Mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2019) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Science, NO.164 Xingang Road, Guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-MAR-2017
            Assembly Method                   :: HGAP v. MAR-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 8458055.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015244315.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:39:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,352
            CDSs (total)                      :: 7,265
            Genes (coding)                    :: 7,077
            CDSs (with protein)               :: 7,077
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 188
            CDSs (without protein)            :: 188
            Pseudo Genes (ambiguous residues) :: 0 of 188
            Pseudo Genes (frameshifted)       :: 106 of 188
            Pseudo Genes (incomplete)         :: 98 of 188
            Pseudo Genes (internal stop)      :: 7 of 188
            Pseudo Genes (multiple problems)  :: 23 of 188
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:52:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5716929
            Orig. end                         :: 5727556
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP043317.1.
            Bacteria and source DNA available from South China Sea Institute of
            Oceanology, Chinese Academy of Science; 164 West Xingang Road,
            Guangzhou 510301, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10627
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="30"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10627
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10627
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5627](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5627
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(746..2239)
                     /db_xref="GeneID:69763326"
                     /locus_tag="FYC74_RS24735"
     CDS             complement(746..2239)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69763326"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986762.1"
                     /locus_tag="FYC74_RS24735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_228123458.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 7.8e-22,
                     bitscore: 76.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLPPIGLRPRVLHVTQPVDGGVARVVTDLTRAQLAAGLRVSVAC
                     PEGGLADRLRALRADVRPWAATRSPGRALPVEVGRLARVIEEVRPDLVHAHSAKAGLAA
                     RLAVRGRVPTVFQPHAWSFEAAGGPTGVLALGWERWAARWAARTVCVSEAERLRGARAG
                     IRGRWAVVPNGVDTDRFHAGPGAGPDDAQDVRRRHGIGPHTPLVVCVGRLCRQKGQDVL
                     LTAWESVLARVPDARLVLAGDGPDRAALTARASAYGLLDVPGASAPPDRHTPAQHTPAP
                     PGRHTPAPPHGRGAAASVLFTGAVADASGWYRAADLVVLPSRWEGMALAPLEAMACGRP
                     VVVTDVDGAREALPPALAPRCLVPPEDPEALADAVAGLLLDAPLRASLARDGHAHVRSA
                     HDVRHTATAVARLYGAVLDAARPSDRATAPGPHRALACDDTRTAARRPAPATTGPAARR
                     PAPGDLGQADVPRKHGMPLKRVEPFECVEPFECRESTHP"
     gene            2502..2741
                     /db_xref="GeneID:69763327"
                     /gene="chpG"
                     /locus_tag="FYC74_RS24740"
     CDS             2502..2741
                     /codon_start=1
                     /db_xref="GeneID:69763327"
                     /gene="chpG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449696.1"
                     /locus_tag="FYC74_RS24740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin ChpG"
                     /protein_id="WP_007449696.1"
                     /transl_table=11
                     /translation="MSRIAKGLALTSVAAAAVAGTAGVAAADSGAQAAAAHSPGVLSGN
                     VVQVPVHIPVNVCGNTIDVIGLLNPAFGNECEND"
     gene            3017..3805
                     /db_xref="GeneID:69763328"
                     /locus_tag="FYC74_RS24745"
     CDS             3017..3805
                     /codon_start=1
                     /db_xref="GeneID:69763328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325463.1"
                     /locus_tag="FYC74_RS24745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_194277640.1"
                     /transl_table=11
                     /translation="MRLPARRIATSALCAGLLIGLSGPAVMAADGDPVRERTRAASLAP
                     LPDAEELQGQVGSLAGLGDMLAPVTDMLDAILKADSGRLSATDADKLAAAVKDALAKAD
                     APDTGTDTGDAATTPGTTTPGTSTPAQPPAAPDADTPVTLPAPVTAQSDDPAAAAPDLA
                     ATAYAELQKQVDALTEATTAGDAAKVSPAVKEVVTGIVNVVAATMVGNGLPAADLAGLP
                     GVPTAPEATTPEATTPEATAPEAAAPEAAAPANPLPADPS"
     misc_feature    complement(3865..3882)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            3977..4267
                     /db_xref="GeneID:69763329"
                     /locus_tag="FYC74_RS24750"
     CDS             3977..4267
                     /codon_start=1
                     /db_xref="GeneID:69763329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325462.1"
                     /locus_tag="FYC74_RS24750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_194277641.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSLVAAGSAVPAFAYDAADTAALTPTSLNGAVNA
                     LTAEPIDIMPVKHQSDALNTENKDSLLHTVKGATTDLNSAGGLLGGLPLGR"
     gene            4345..4860
                     /db_xref="GeneID:69763330"
                     /locus_tag="FYC74_RS24755"
     CDS             4345..4860
                     /codon_start=1
                     /db_xref="GeneID:69763330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976098.1"
                     /locus_tag="FYC74_RS24755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_194277642.1"
                     /transl_table=11
                     /translation="MRPTTRRTLAAVVTGVAAALGAAATPAAAAGAVPVPVPLDGAETA
                     LGMELPEVTGALPVPTAGAPEGPRYVEGRLLPERTLPQLPVHAGLPGADVRQPLPRVLG
                     DDFDHAALDAPAAELRTLAPGLSLDAPLTAPNPEALGLPSAKLPEVGVLTPVLQTGPVA
                     DLGVGPGL"
     gene            5001..5627
                     /db_xref="GeneID:69763331"
                     /locus_tag="FYC74_RS24760"
     CDS             5001..5627
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69763331"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028525.1"
                     /locus_tag="FYC74_RS24760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_194277643.1"
                     /sec_met_domain="melC (E-value: 1.1e-46, bitscore: 157.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVNAGAPVSGAERKREHPPEGGGLAGNGSSGGGAADGGPASGGA
                     ASAAAASGTRRQMMRGLLAPALAVTLVPLVAASRPFRAEATAQGADAAPPGPRAAERAG
                     QETGGTAFDETYRGRRIRGIRSAAGRAVGAGTWHVTVDGRPLHLMRRADGSWLSMIDHY
                     RSYPTPLEAARGAVDELGPAEQVRDTPGDDAGHDHHTGGRHGVHA"
     gene            5611..6477
                     /db_xref="GeneID:69763332"
                     /locus_tag="FYC74_RS24765"
     CDS             5611..6477
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69763332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="FYC74_RS24765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_194277644.1"
                     /transl_table=11
                     /translation="MAYTRKDVSTLTRTEKRRFVNALLEIKRRGEYDEFVRTHIEYYVS
                     DGEDGLRTAHMAPSFLPWHRRFVLDLEEALRRVDSSVTVPYWDWTKDRGAKSTPWTADL
                     LGGTGRRSDRRVTTGPFAHAEGNWTLRENVTDTEYLTRDLGRAADPIDLPSKSDLEWAL
                     DDATYDTSPYDSTVRKGFRNKLEGWGTGRGSVSWRNHNRVHRWVGGAMVGGASVNDPVF
                     WLHHAFIDLQWSRWQARHRGARYLPAEPPGRGSAQRGRIVARHEKLPPWDVTPDEMEDV
                     GRIYRYA"
     gene            complement(6606..6884)
                     /db_xref="GeneID:69763333"
                     /gene="chpF"
                     /locus_tag="FYC74_RS24770"
     CDS             complement(6606..6884)
                     /codon_start=1
                     /db_xref="GeneID:69763333"
                     /gene="chpF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028524.1"
                     /locus_tag="FYC74_RS24770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin ChpF"
                     /protein_id="WP_031040144.1"
                     /transl_table=11
                     /translation="MSRIAKAAGVVLGAGAVALSGTGMAMADAGAQGAAVGSPGVLSGN
                     VVQVPVHVPVNVCGNTIDVIGLLNPAFGNSCENESGHHSDKSGGYGG"
     misc_feature    6985..7000
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.87"
                     /tool="antismash"
     gene            7071..7703
                     /db_xref="GeneID:69763334"
                     /locus_tag="FYC74_RS24775"
     CDS             7071..7703
                     /codon_start=1
                     /db_xref="GeneID:69763334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449721.1"
                     /locus_tag="FYC74_RS24775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2087 domain-containing protein"
                     /protein_id="WP_194277645.1"
                     /transl_table=11
                     /translation="MSNDPNDLSHAFPPATGAGVASAVAALPALFAEESRVRAFAAVAL
                     GAGDAAQVARAAGLSAKETAGALRRLREHGVVTSGDDGGLVVAQGRFRELARAARPAAE
                     AAGTPGAAGGGREGMILRTFVKDGRLVRLPARWTRKKVVLRHIAEQTFAPGVEYPERTV
                     DGKLRAWCEDGEVDHVTLRRHLVDFGHLRRSGGTYWRPAEPARAGTA"
     gene            complement(7766..8731)
                     /db_xref="GeneID:69763335"
                     /locus_tag="FYC74_RS24780"
     CDS             complement(7766..8731)
                     /codon_start=1
                     /db_xref="GeneID:69763335"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325456.1"
                     /locus_tag="FYC74_RS24780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_194277646.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.7e-51, bitscore:
                     171.7, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRCAVLDDFQQVAKEAADWSSVAGEVDVVSFDAHLPDEDALAA
                     ALADFDIVVTLRERVAFPGSLLARLPRLRLIVASGMRNSVIDYAAAEAHGVTVCGTASS
                     STPPVELTWALLLGLARGLVRESNGLREGGPWQQTVGADLHDRRLGLLGLGKIGSRVAQ
                     VGLAFGMRVSAWSQNLTRERADEVGVELAPSREELLRTADFVSVHLALGERTRGLLGPA
                     ELALLKPTAYLVNTSRAAIVDQDALLAALHEGRIAGAGVDVFDTEPLPAGHPMRTAPHL
                     LATPHLGYVSQANYATYYGQAVEAIRSYLAGSPVRRLPAP"
     gene            complement(8893..10230)
                     /db_xref="GeneID:69763336"
                     /locus_tag="FYC74_RS24785"
     CDS             complement(8893..10230)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69763336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978040.1"
                     /locus_tag="FYC74_RS24785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_194277647.1"
                     /transl_table=11
                     /translation="MFSLAMRSVRHRPGRFGATLLASFLGAAIIMAFNSLHDTAGAPGV
                     DDVSSETLGLAAGVVGGYGTLLVFFAVASTLTVNVRQRDEEIALLRSAGATPAQIRWMV
                     VGEAAAVAVVAALLAVGPAVLGGQALLTGFQDSGQVAKDVDHVFGPVAVAAGFGVTVSA
                     SMGAAFLAVRRATRAAAGTARASGRWRRLGGWAALALGTAAVGATFTFDATDPGLMAAP
                     AYGAILLSVGLAVFSPALLRVLLDRLERPLGTLFGASGLLAVQNMRRRATQLSGVLMPL
                     VLFTGMATGTLYMQSIENDAIDASGLTRSVEDKNLETLNLTVVGIIVVFSCIMLINSLY
                     AATSYRRREFGQQRLAGATPGQVLGMVGVEALVLTVSGIVLGSAAAVAGILPFSSVRAS
                     ALVPDQGLGTWLGIVAVAAAATLATSVVTARRTLRTPAVRAVAVTA"
ORIGIN
        1 gtccgcagca gcgccgcctg ccggggacgt acggcggggg ccacggcgag gacgtcgcgc
       61 acgccgttct gcaccaccgc ccgccgcgcc tcctcacccg tggacagcac gggcaggccc
      121 gcggtgccgt ccgggtcgtc ggtgacgacc ccgacgggac gcaccccgca gcgcgggtgg
      181 cgcagcagcg ccgacgccac ccgctgggcg gtcgcggcgg gcccgacgac gagggccgcg
      241 cggggacggt tcgacagcgc cctgcggcgc ctgcggtgca cggcgccccg gccggcgcag
      301 cccgtcgccg cgtgcagcag gaaaccggcg agcagcgtgc gggcggacag cgcctgcgcc
      361 ggggcgtacg ccgcgacgag cgccgccagt gccagccaga ccaccgcgat gcgggcgcac
      421 agcgccggca gttcgtccag cacgccgaag accggccggg cggcggccgg gtccggcttt
      481 cggcgcagca ggagcgaggt gccgaccagc agggcggcga gcaggggctg gtgcggggcg
      541 ccgatgagca tcagcgagcc cggcagggcc gccgcgccgt ccgcgacgag caacggcagc
      601 ggggagtcgg gccgggcggc ggtacgccgg gcgggcagtc gcgggccgcc gcccgccgca
      661 ccggcccgct gcggcagcac cgagacgggg gaggggccga ggccccgagg ccggccggcg
      721 ggggtgggga cggtgctttc cgcggtcacg ggtgggtgga ctccctgcac tcgaagggct
      781 cgacgcactc gaagggctcg acgcgcttga ggggcatgcc gtgcttgcgg ggcacgtcgg
      841 cctgccccaa gtcgccgggg gccgggcgcc gtgcggcggg cccggtggtg gcgggggccg
      901 ggcgccgtgc ggcagtccgg gtgtcgtcgc aggccagggc ccggtgggga ccgggggccg
      961 tggcccggtc ggacggacgt gcggcgtcga gcacggcgcc gtacagccgt gcgaccgccg
     1021 tggccgtgtg ccgtacgtcg tgcgcggagc ggacgtgggc gtggccgtcg cgggcgagcg
     1081 acgcgcgcag gggcgcgtcg agcaggaggc cggcgaccgc atcggccagg gcttccgggt
     1141 cctcgggcgg caccaggcag cgcggcgcga gcgcgggcgg cagggcctcg cgggcaccgt
     1201 ccacgtcggt caccaccacg gggcgcccgc aggccatcgc ctccagcggg gccagcgcca
     1261 tgccctccca gcgcgacggc aggacgacca ggtcggcggc ccggtaccag ccggaggcgt
     1321 cggccacggc acccgtgaac agcacggacg ccgcggcgcc ccggccgtgc ggcggcgcgg
     1381 gagtgtgccg gccgggtggc gcgggagtgt gctgcgcggg agtgtgccga tcgggcggcg
     1441 cggaggcgcc cgggacgtcg aggaggccgt acgccgacgc ccgcgcggtg agcgcggcgc
     1501 ggtccggtcc gtcaccggcc aggaccagcc gggcgtccgg cacacgcgcg agaaccgact
     1561 cccacgcggt gagcagcacg tcctggccct tctgccggca cagccgcccc acgcagacca
     1621 ccaacggggt gtgcgggccg atgccgtgcc gtcgccgtac gtcctgcgcg tcgtccgggc
     1681 cggcgccggg cccggcgtgg aagcggtccg tgtcgacgcc gttcgggacc accgcccacc
     1741 gcccgcggat cccggcccgc gccccgcgca gccgttccgc ctcgctcacg cacaccgtgc
     1801 gcgccgccca ccgcgcggcc caccgctccc agccgagcgc gaggaccccg gtgggtccgc
     1861 cggccgcctc gaacgaccag gcgtgcggct ggaacacggt cgggacccgc ccccgtacgg
     1921 cgagccgcgc ggccagaccg gccttggcgc tgtgggcgtg gaccaggtcg ggccgcacct
     1981 cctcgatcac gcgggcgagg cgacccacct ccaccggcag ggcccggccc ggcgagcgcg
     2041 tcgccgccca gggccgcacg tccgcgcgca gggcgcggag ccggtcggcg agacctccct
     2101 cggggcaggc gacggacacc cgcagcccgg cggcgagctg agcgcgcgtc aggtccgtca
     2161 ccacccgggc gaccccgccg tccaccggct gggtgacatg cagaacccgt ggccgtaggc
     2221 cgatcggtgg caggtgcata cgcgtgtcct tgcgcggcat gggtgagaca ggggcgcaaa
     2281 cggagtgcga caggggcgtg acagaggtgc gtcgaacggt gtgggactct agccgctatc
     2341 cgtactaata cggtgaaacc gggaagtgtg ttggatttgt gaatggcggt ccccggcgac
     2401 atcacccctt tggcggcaca actcccgtac ctgccacgcg ttgacactgc gccgggcacc
     2461 cccgcccgga tgtatgtcgc aaccccaagg agcacttctc catgtcgcgt atcgcgaagg
     2521 gcctggccct gacctccgtc gccgccgccg cggtggcggg caccgccggt gtcgccgccg
     2581 ccgacagcgg cgcgcaggcc gccgccgccc actccccggg cgtcctgtcc ggcaacgtgg
     2641 tgcaggttcc ggtccacatc ccggtcaacg tctgcggtaa caccatcgac gtcatcggcc
     2701 tgctgaaccc ggcgttcggc aacgagtgcg agaacgactg acgtcggctc gcgactcccg
     2761 caccggccgt ccgtaccgcg gttcttccgc gagcgggcgg ccggttcgcg ttgccgcgcg
     2821 gacggtggtg tgctgccccg aatggggggt ccgggcgccg acacggacca ctgaccttga
     2881 cagggcgtct caccaggtaa gacgcgaacg gcggcgcgtg cggcccggca caccgggtca
     2941 ccgctcggtt gcagagcgcc ggggccgctt ccacggtggg cacaagatcc gacgcgccac
     3001 cgaaaggaac cccctcatgc gtctgcccgc acggcgaatc gccacctccg ctctctgcgc
     3061 cggcctgctg atcggtctct cgggtccggc ggtgatggcg gccgacggcg acccggtccg
     3121 ggaacgcacc cgcgcggcct ccctcgcccc cctccccgac gccgaggaac tgcagggcca
     3181 ggtcggcagc ctggccggtc tgggcgacat gctcgctccg gtcaccgaca tgctcgacgc
     3241 gatcctcaag gccgacagcg gccggctctc cgccacggac gcggacaagc tcgccgccgc
     3301 cgtcaaggac gccctcgcga aggccgacgc cccggacacc ggcacggaca ccggcgacgc
     3361 ggcgaccacc cccggtacga ccacccccgg caccagcacc ccggcccagc ccccggccgc
     3421 gccggacgcc gacacccccg tcacgctgcc ggcgcccgtc accgcgcaga gcgacgaccc
     3481 cgcggcggcg gcgcccgacc tggcggccac cgcgtacgcc gagctgcaga agcaggtcga
     3541 cgccctgacc gaggccacca ccgccggtga cgccgcgaag gtgagcccgg cggtcaagga
     3601 ggtggtgacc ggcatcgtca acgtcgtcgc cgccaccatg gtcggcaacg gcctgcccgc
     3661 cgcggacctg gcgggcctgc ccggcgtacc gaccgcgccg gaggccacga ctcccgaggc
     3721 caccactccg gaggccacgg ctccggaagc cgccgccccc gaggccgccg cgcccgcgaa
     3781 cccgctgccc gccgacccct cctgaccttc gcccacgtcg gcctcacggg ccgccgcgcc
     3841 tccctgtcgg acggcgcggc ggcctttccg cttttcgggc aatctcggct ccggagatct
     3901 catatgtctt ccggacggcg gagtttccgg gtcctcggca gatcgttagg gaggaaaagt
     3961 cgaagaaagg aacacgatga agtccctcaa ggccgccgcc gtcgtcgccg gttccctggt
     4021 cgccgccggt tccgccgtgc ccgctttcgc gtacgacgcc gccgacaccg ccgccctcac
     4081 ccccaccagt ctcaacggcg ccgtgaacgc actgaccgcc gagcccatcg acatcatgcc
     4141 ggtcaagcac cagtcggacg cgctcaacac cgagaacaag gactccctgc tgcacaccgt
     4201 gaagggcgcg accaccgacc tgaattccgc aggcggcctc ctcggcggcc tcccgctggg
     4261 ccgctgagcc gcttctccct cggcatcctc ctccactctt ccccccactg tttccccgca
     4321 ttctcgaaag gggccgtgcc tgacatgagg ccgaccacca gacgaaccct ggccgccgtc
     4381 gtcaccggcg tggccgccgc cctgggggcg gccgcgaccc cggccgccgc ggccggcgcg
     4441 gtccccgtgc cggtgccgct ggacggcgcc gagaccgctc tcggcatgga actgccggag
     4501 gtgaccggcg cactgcccgt gccgaccgcg ggcgcccccg aggggccccg gtacgtcgag
     4561 ggacggctgc tgcccgagcg gactctcccg caactgccgg tgcacgccgg cctccccggc
     4621 gccgacgtgc gccagccgct gccgcgcgtc ctcggagacg acttcgacca cgccgccctc
     4681 gacgctcccg ccgccgaact gcggaccctg gcgccgggcc tgtccctgga cgccccgctc
     4741 accgcgccga accccgaggc cctcggcctg ccgtccgcca agctgcccga ggtcggcgtg
     4801 ctcacccccg tactgcagac ggggccggtg gccgacctgg gcgtcggccc ggggctgtag
     4861 ctccaggcgt actccgcgct ccgtggcgcg gccgtgctcc gtggcgcggc cgtgctccga
     4921 ctggccctgc ggacagtgac cgcggggctc gccgtgcggt tagcggtggg aaaccaccgg
     4981 aatcggacga ggagcgagtc atggtcgtca acgcgggtgc gccggtgagc ggcgcggagc
     5041 ggaagagaga gcacccgccg gagggcggag gcctggcggg caacggttcg tcgggtggcg
     5101 gtgcggcgga cgggggaccg gcgtccggcg gggcggcgtc cgccgccgcg gcgtccggta
     5161 cgcggcggca gatgatgcgg gggctgctcg ccccggccct cgccgtgacg ctggtccccc
     5221 tggtcgccgc ctcccggccg ttccgggccg aggccaccgc gcagggggcg gacgccgcgc
     5281 ctcccgggcc acgcgccgcc gaacgggcgg ggcaggagac cgggggcacc gccttcgacg
     5341 agacgtaccg cggccggcgc atccgcggca tccggtccgc cgcggggcgg gccgtcggcg
     5401 ccggcacctg gcacgtcacc gtggacggcc gcccgctgca cctgatgcgc cgggccgacg
     5461 gcagctggct gagcatgatc gaccactacc gctcgtatcc caccccgctg gaggcggccc
     5521 ggggcgccgt cgacgaactc ggccccgccg agcaggtgcg cgacacgccg ggcgacgacg
     5581 ccgggcacga ccaccacacc ggggggcggc atggcgtaca cgcgtaagga cgtcagcacg
     5641 ctgacccgca ccgagaagcg ccggttcgtc aacgcgctgc tggagatcaa gcggcgcggt
     5701 gagtacgacg agttcgtgcg cacccacatc gagtactacg tctccgacgg cgaggacggc
     5761 ctgcgtacgg cgcacatggc gccgtccttc ctgccgtggc accgccggtt cgtgctggac
     5821 ctggaggagg cgctgcgccg ggtcgactcg tcggtcaccg tgccctactg ggactggacg
     5881 aaggaccgcg gcgccaagtc gacgccctgg accgccgacc tgctgggcgg caccgggcgg
     5941 cgttccgacc ggcgcgtcac caccggcccc ttcgcccacg ccgagggcaa ctggaccctc
     6001 agggagaacg tcaccgacac ggagtacctc acccgggacc tcggacgcgc ggccgacccc
     6061 atcgacctgc cctccaagag cgacctggag tgggcgctgg acgacgcgac gtacgacacc
     6121 tcgccgtacg actccacggt ccgcaagggg ttccgcaaca agctggaggg ctggggcacc
     6181 ggccggggca gtgtctcctg gcgcaaccac aaccgcgtgc accgctgggt cggcggcgcc
     6241 atggtcggcg gcgcctccgt caacgacccg gtcttctggc tgcaccacgc cttcatcgac
     6301 ctgcagtggt cgcgctggca ggcccgccac cgcggcgccc gctacctccc cgccgagccg
     6361 cccggccggg gcagcgcgca gcgcggacgg atcgtcgcac ggcacgagaa gctgccgccg
     6421 tgggacgtga cgccggacga gatggaggac gtcggccgaa tctaccggta cgcctgaagg
     6481 cttggagatc tggagatctg gagatctgga ggctacgagg cttgaaggtc tgaaggtctg
     6541 aacggggcgg gcaggggaag agccccggcc ggggcggccg gggctcttcg ctgcctgcgg
     6601 ggcactcagc cgccgtagcc accgctcttg tcggagtggt ggccgctctc gttttcgcag
     6661 ctgttgccga aggccgggtt cagcaggccg atcacgtcga tggtgttgcc gcacacgttg
     6721 accggcacgt gcaccgggac ctggacgacg ttgccggaca ggacgccggg cgaaccgacg
     6781 gccgcgccct gcgcgcccgc gtccgccatg gccatcccgg tgccgctgag cgccacggca
     6841 ccggcgccga ggacgacacc ggcggccttc gcgatgcgag acatcacgta ctccttctga
     6901 ctcggggagc gcgacggcag gacgcgccgc cgcactgcag gttcaacgca cccggtcgca
     6961 gcgggtcacg gggagaatgt gaggatcacc ctttttgaac gggagggcga gagggagggg
     7021 cggcggaaaa ccgttcccct gcgcgccggg gcgtccacta gcctcccggc atgtcgaacg
     7081 acccgaacga cctgtcccac gcgttccctc cggccaccgg ggccggcgtg gcgtccgccg
     7141 tggccgcgct gcccgccctc ttcgccgagg agagccgggt acgcgccttt gcggccgtgg
     7201 cgctgggcgc gggcgacgcc gcgcaggtgg cccgcgcggc cggcctctcc gcgaaggaga
     7261 cggcgggcgc gctgcgccgg ctgcgggaac acggcgtggt gacctccggg gacgacggcg
     7321 gactcgtcgt cgcccagggc cgtttccggg aactggcgcg cgccgcacgc cccgcggcgg
     7381 aggcggccgg cacccccggg gcggccggcg gcggccggga gggcatgatc ctgcggacct
     7441 tcgtcaagga cgggcggctg gtccggcttc cggcgcgctg gacacgcaag aaggtggtgc
     7501 tgcggcacat cgccgagcag accttcgccc ccggagtgga gtaccccgag cgcaccgtcg
     7561 acgggaagct gcgggcctgg tgcgaggacg gggaggtcga ccatgtgacg ctccggcgcc
     7621 atctcgtgga cttcggccac ctgcgccgga gcggcggaac ctactggcgc cccgcggagc
     7681 ccgcccgtgc gggaaccgcg tgaccgaacc gcctgaccga accgcctaac ggaatggcct
     7741 gtccgaaccg cctgaccgcg cgagcctacg gcgcgggcag gcggcgtacg ggggatccgg
     7801 ccaggtagga ccggatcgcc tcgaccgcct ggccgtagta cgtggcgtag ttggcctgcg
     7861 agacgtagcc gaggtgcggg gtggcgagca ggtgcggggc ggtgcgcatc gggtggccgg
     7921 cgggcagcgg ctcggtgtcg aagacgtcca cgccggcgcc ggcgatgcgg ccctcgtgca
     7981 gtgcggccag cagggcgtcc tggtcgacga tggccgcacg cgaggtgttg accaggtagg
     8041 cggtcggctt gagcagggcc agttcggcgg ggcccagcag accgcgggtg cgctcgccga
     8101 gggccaggtg gacggagacg aagtcggcgg tccgcaggag ctcttccctg gagggcgcca
     8161 gttcgacgcc gacctcgtcg gcgcgctccc gggtgaggtt ctggctccac gcgctcaccc
     8221 gcatgccgaa ggcgaggccg acctgcgcca cccggctgcc gatcttcccc aggcccagca
     8281 gcccgagccg gcggtcgtgc aggtcggcgc ccaccgtctg ctgccagggg ccgccctcgc
     8341 gcagcccgtt gctctcccgg acgagcccgc gggccaggcc gagcagcagg gcccaggtca
     8401 gttcgacggg cggggttgag gaggaggccg tgccgcacac ggtgacgccg tgcgcctcgg
     8461 cggcggcgta gtcgatcacg ctgttgcgca tgccggaggc gacgatcagc cgcaggcggg
     8521 gcagccgggc cagcagcgag ccggggaagg ccacgcgttc gcgcagggtg accacgatgt
     8581 cgaagtcggc cagcgcggcg gcgagggcgt cctcgtcggg gaggtgggcg tcgaaggaca
     8641 cgacgtcgac ctcgccggcg accgaggacc agtccgcggc ctccttcgcc acctgctgga
     8701 agtcgtcgag taccgcgcag cgcagtcgca cgtcgtccgg tcccttccgc cgagcgggca
     8761 gtgacacccc cggcggggcg cccggcccaa cgtacagcgg gcgccgcgcc ccgtgtacga
     8821 cggggtgcgg cgcccaacgc aggtacggcg ggcctgccgt ccgcccaacg tacgtacggc
     8881 gggcctccag ggtcaggcgg tgaccgccac cgcacgtacc gccggtgtgc gcagcgtgcg
     8941 ccgggccgtc accacgctgg tggccagcgt cgccgcggcg gcgaccgcca cgatgcccag
     9001 ccatgtcccc aggccttggt ccggcacgag cgcggaggcg cgcaccgagc tgaacggcag
     9061 gatgcccgcc acggcggccg cactgccgag gacgatgccg gacaccgtga gcaccagggc
     9121 ctccacaccg accatgccga ggacctgacc cggcgtcgcc ccggccagtc gctgctggcc
     9181 gaactcccgg cggcggtacg aggtcgcggc gtacaggctg ttgatcagca tgatgcagga
     9241 gaagaccacg atgatgccga ccaccgtgag gttgagggtc tccaggttct tgtcctcgac
     9301 ggagcgggtg aggcccgagg cgtcgatcgc gtcgttctcg atggactgca tgtacagcgt
     9361 cccggtcgcc atgccggtga acaggaccag cggcatcagt acgccggaca actgcgtggc
     9421 ccgccgccgc atgttctgca cggccagcag gccgctcgcc ccgaacagcg tgcccagcgg
     9481 ccgctccagc cggtcgagga ggacgcgcag cagcgccggg gagaagacgg cgagaccgac
     9541 ggagagcagg atcgcgccgt acgcgggggc cgccatcagc ccgggatccg tcgcgtcgaa
     9601 cgtgaacgtg gcgcccaccg ccgccgtgcc gagggcgagc gccgcccagc cgcccagccg
     9661 ccgccaccgt ccggaggccc gcgccgtgcc cgccgcggcc cgcgtcgcgc ggcgcaccgc
     9721 gaggaaggcg gcccccatgg aggccgatac ggtgaccccg aacccggccg ccaccgcgac
     9781 cggcccgaac acgtggtcca cgtccttcgc gacctggccg ctgtcctgga acccggtcag
     9841 cagggcctgc ccgccgagca cggccgggcc gacggccagc agcgccgcca ccacggcgac
     9901 cgcggcggcc tcgcccacca ccatccaccg gatctgcgcc ggggtggcgc cggcgctgcg
     9961 cagcagggcg atctcctcgt cgcgctgccg gacgttgacg gtcagcgtgg acgcgacggc
    10021 gaagaacacc agcagggtgc cgtagccgcc caccacaccc gcggcgaggc cgagcgtctc
    10081 ggagctgacg tcgtcgacgc ccggcgctcc ggcggtgtcg tgcagcgagt tgaacgccat
    10141 gatgatcgcg gcgcccagga acgaggcgag cagcgtggcg ccgaagcgcc cggggcggtg
    10201 cctgacggaa cgcatggcca gggagaacac ggctcacacc tccagaccgg cggtgtcgcc
    10261 cgcgggagcg gggtcgccca ggtgcgcgag ccgctcggcg acggcgtcca cggtcggcgc
    10321 ggtcaggtgt ccggcgggcc gtccgtccgc gaggaagacg acggagtcgg cgtacgaggc
    10381 ggccaccggg tcgtgcgtca ccatgacgac ggtccggccg tgcagccgca ccgcctcctg
    10441 cagcagccgc agcacgtccc gggcgctgcg cgtgtcgagt gctcccgtcg gttcgtcggc
    10501 gaagaccacg ctgggctcgg tgaccagcgc gcgggcgatg gcgacgcgct ggcgctggcc
    10561 gccggagagc tggtcgggca gggcgtcgag gcggtcgccg agaccgacct gggtgaggat
    10621 ctcccgg
//
