LOCUS       NZ_CP043317            21053 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces olivaceus strain SCSIO T05 chromosome, complete genome.
ACCESSION   NZ_CP043317
VERSION     NZ_CP043317.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivaceus
  ORGANISM  Streptomyces olivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated
            Production of Lobophorin CR4 via Metabolic Engineering and Genome
            Mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2019) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Science, NO.164 Xingang Road, Guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-MAR-2017
            Assembly Method                   :: HGAP v. MAR-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 8458055.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015244315.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:39:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,352
            CDSs (total)                      :: 7,265
            Genes (coding)                    :: 7,077
            CDSs (with protein)               :: 7,077
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 188
            CDSs (without protein)            :: 188
            Pseudo Genes (ambiguous residues) :: 0 of 188
            Pseudo Genes (frameshifted)       :: 106 of 188
            Pseudo Genes (incomplete)         :: 98 of 188
            Pseudo Genes (internal stop)      :: 7 of 188
            Pseudo Genes (multiple problems)  :: 23 of 188
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:52:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4275008
            Orig. end                         :: 4296061
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP043317.1.
            Bacteria and source DNA available from South China Sea Institute of
            Oceanology, Chinese Academy of Science; 164 West Xingang Road,
            Guangzhou 510301, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="27"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21053
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11053](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11053)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(93..108)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.44"
                     /tool="antismash"
     gene            complement(342..839)
                     /db_xref="GeneID:69762038"
                     /locus_tag="FYC74_RS18245"
     CDS             complement(342..839)
                     /codon_start=1
                     /db_xref="GeneID:69762038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240229.1"
                     /locus_tag="FYC74_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoribosyltransferase"
                     /protein_id="WP_031043808.1"
                     /transl_table=11
                     /translation="MSDVRENLTYEQFGAAVRELAQTVADDGYEPDVVLSIARGGVFVA
                     GGLAYALDCKNIHLVNVEFYTGVGTTLDMPVMLAPVPNVIDFSDKKVLITDDVADTGKT
                     LKLVRDFCLDTVAEVRSAVIYEKSHSLVQCEYVWKRTDDWINFPWSVLPPVVRRDGQVL
                     DA"
     gene            complement(865..1440)
                     /db_xref="GeneID:69762039"
                     /gene="dcd"
                     /locus_tag="FYC74_RS18250"
     CDS             complement(865..1440)
                     /EC_number="3.5.4.13"
                     /GO_function="GO:0008829 - dCTP deaminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006229 - dUTP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762039"
                     /gene="dcd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948066.1"
                     /locus_tag="FYC74_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dCTP deaminase"
                     /protein_id="WP_031043809.1"
                     /transl_table=11
                     /translation="MLLSDKDIRAEIDNGRVRIDPLDDSMVQPSSIDVRLDRYFRVFEN
                     HRYPHIDPSVEQVDLTRLVEPEGDEPFILHPGEFVLASTYEVITLPDDLASRLEGKSSL
                     GRLGLVTHSTAGFIDPGFSGHVTLELSNLATLPIKLWPGMKIGQLCMFRLTSPAEHPYG
                     SERYGSRYQGQRGPTASRSYLNFHRTQV"
     tRNA            1977..2050
                     /anticodon=(pos:4277017..4277019,aa:Gly,seq:ccc)
                     /db_xref="GeneID:69762040"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FYC74_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Gly"
     gene            1977..2050
                     /db_xref="GeneID:69762040"
                     /locus_tag="FYC74_RS18255"
     misc_feature    1986..2002
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.05"
                     /tool="antismash"
     misc_feature    2007..2021
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    2144..2158
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.87"
                     /tool="antismash"
     gene            complement(2385..2795)
                     /db_xref="GeneID:69762041"
                     /locus_tag="FYC74_RS18260"
     CDS             complement(2385..2795)
                     /codon_start=1
                     /db_xref="GeneID:69762041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126922.1"
                     /locus_tag="FYC74_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PIN domain-containing protein"
                     /protein_id="WP_194276763.1"
                     /transl_table=11
                     /translation="MMYLLDTSGLVRLLRDANLQSAWHDAIDAGAIASCYVQRTEFLYS
                     ARNRSEYDEIAEMFSDLYPDAAVPKNAGRWISAVQHRMAQAGEHRSASAVDLVIAATAA
                     HHGLTVLHDDADYGTVARHASDLNEHNVHDVA"
     gene            complement(2792..3013)
                     /db_xref="GeneID:69762042"
                     /locus_tag="FYC74_RS18265"
     CDS             complement(2792..3013)
                     /codon_start=1
                     /db_xref="GeneID:69762042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004928730.1"
                     /locus_tag="FYC74_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_031046014.1"
                     /transl_table=11
                     /translation="MSVTQIDIDDDALERAMALAHVRTKKEAVNLALHFYAEQQERAAR
                     ISRHFERAREWGAVEDAERLHRVEKRSR"
     misc_feature    2984..2998
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    complement(2994..3007)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            3191..3883
                     /db_xref="GeneID:69762043"
                     /locus_tag="FYC74_RS18270"
     CDS             3191..3883
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762043"
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150741.1"
                     /locus_tag="FYC74_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_194276764.1"
                     /transl_table=11
                     /translation="MTARREPISRRERPAKAALSRRWIVDTAVRVMRAEGLEKVTMRRL
                     AKELDTGPASLYVYVANTAELHAAVLDALLGEVDLAGGGAGDDWRGQLRAVLASYTSVL
                     FAHPQLARSALVARPSGVNYLRLVERVLDLLSRSGASREQVAWGVDKLLQDATATAAEQ
                     SAQEHDPMTEDDWNATTRALRSVDEAHPAIRAHMPALVSGSPEDRMGWSFDVLVNGITR
                     TPVPGTDG"
     gene            4047..5186
                     /db_xref="GeneID:69762044"
                     /locus_tag="FYC74_RS18275"
     CDS             4047..5186
                     /codon_start=1
                     /db_xref="GeneID:69762044"
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578423.1"
                     /locus_tag="FYC74_RS18275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_194276765.1"
                     /transl_table=11
                     /translation="MSTHHPVAIIGGGLGGLTAARVLHVNGVRAAVFELEASAAARTQG
                     GMLDIHEENGQKALHAAGLHEDFLKIVHGGGQEMRLVGPDATVHVREQDDGTGARPEVD
                     RGDLRHLLLNSLPDGTIRWGKKATTLRALGDGRHEVTFADGSTVTTDLLIGADGAWSRV
                     RPLLSAATPAYTGISFAETDLHDADARHPRGAALVGGGFFISLSEGRGFLAHRETDGSL
                     HVYAALKADEDWLDTVDFTDLTAAKAAVLARFEGWHEDLRGLVAGADTVTPRRIHALPV
                     GHRWERTAGVTLLGDAAHLMSPFAGEGANLAMLDGAELAETIAAHPGDTESALASYEQA
                     LFPRSEASAVESAASLETMFGDRGLEQMIEFFTAGPAAG"
     gene            complement(5234..6130)
                     /db_xref="GeneID:69762045"
                     /locus_tag="FYC74_RS18280"
     CDS             complement(5234..6130)
                     /codon_start=1
                     /db_xref="GeneID:69762045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451192.1"
                     /locus_tag="FYC74_RS18280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_194276766.1"
                     /transl_table=11
                     /translation="MTTEHTRLVAALRELKAGSGLSLAALAERTPYSKSSWERYLNGKS
                     LPPRQAVRDLCRLANEPDGRLLALWEIAESRWSGRATPPAPAAPAPSTDEPPQSPPQQA
                     PPPTGAGRRRARGRLLLALASAYTVIVGGAAALLFLLLPDSEAREDEPPTASVPFSLAP
                     QCQGAACEGRDPMRLICGIGPDTLASHRTATGAHVELRHSTKCGASWVRTWGTEIGDRV
                     DVTAGGPTHDVRIRNEEDAAAFVYTEMTEVGPGSTVRACFRPAAPDGERECFEARVDGP
                     ATTTEPPSSPAASSPRA"
     gene            complement(6127..6930)
                     /db_xref="GeneID:69762046"
                     /locus_tag="FYC74_RS18285"
     CDS             complement(6127..6930)
                     /codon_start=1
                     /db_xref="GeneID:69762046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015580397.1"
                     /locus_tag="FYC74_RS18285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_228123403.1"
                     /transl_table=11
                     /translation="MSHWRELPAELHPDVRHLIVRLRGLKDRSELSKRRLAAKTGYSAK
                     SWQRYLNGRSLPPREAVESMARVGGDNPHRLLVLHEIAAQRWSEGRAVTATAPAPDDGP
                     APPEHAPTEHHPQGRHLRVAVTVAAVVTALSVTAALLLAVRLTEARAQLADERAGVAAT
                     AVATVSESMVPVIYTCELEQRDGRWYAGLSRTTDILLSNTQMGLEVAEAQCLLQRAGSE
                     PGDIDGVFGPKTRRAVERMQKRGGLIVNGVIDPPTWQALREGAPQ"
     misc_feature    6980..6994
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.3"
                     /tool="antismash"
     gene            7287..7661
                     /db_xref="GeneID:69762047"
                     /locus_tag="FYC74_RS18290"
     CDS             7287..7661
                     /codon_start=1
                     /db_xref="GeneID:69762047"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FYC74_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_194276768.1"
                     /transl_table=11
                     /translation="MKKRVGPRSWLTAGVVASVLAGGSVFFGASPAAAAACGASLSVKT
                     AGASAAWDVACDAGHIRVVGWVKDTDNDGQCARVRVEYADGHKWYSPQACPKGTKVSFG
                     SPWSDTKSQIINAYLYEFDV"
     gene            7779..8150
                     /db_xref="GeneID:69762048"
                     /locus_tag="FYC74_RS18295"
     CDS             7779..8150
                     /codon_start=1
                     /db_xref="GeneID:69762048"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FYC74_RS18295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_194276769.1"
                     /transl_table=11
                     /translation="MKASRKIRTLTAGAAASLVLGVGATLLTVGPAAAAGCGATLNPKT
                     SGAEAFWEVKCVGTQRVGIAGWVKDTDNDGQCARVKATFPNGTTYYSPQACPKGTKVNF
                     SSGWRSGALVDAYLYEFDV"
     gene            8282..8750
                     /db_xref="GeneID:69762049"
                     /locus_tag="FYC74_RS18300"
                     /pseudo=""
     CDS             8282..8750
                     /codon_start=1
                     /db_xref="GeneID:69762049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968999.1"
                     /locus_tag="FYC74_RS18300"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF1707 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSLPEESPSLIREDDRDAAVRRLQEAYAEGLIAHEVLDERLHQV
                     LSATTRGALASALVSLPEEPPARTATIGAAGGRIKRHGAWRVPRVLKAESAYGRGRNHG
                     AS"
     misc_feature    8291..8293
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8302..8316)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.79"
                     /tool="antismash"
     gene            complement(8811..9974)
                     /db_xref="GeneID:69762050"
                     /locus_tag="FYC74_RS18305"
     CDS             complement(8811..9974)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120375.1"
                     /locus_tag="FYC74_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_194276770.1"
                     /transl_table=11
                     /translation="MTYSEASMDSLRQTGDELADAVVATLFERGEVGTFNSLMRYVSTA
                     GTPLPDGLPEVAREYLQATSVPPAWVDWGEMEKARLFFIDNNVHISTALSFAAMPACYV
                     VPHVAKLLSATHGLNYPSKRMAETGQFTVYLMQPDAFEAGGRFIPAAQKVRLLHASIRH
                     HLKRENRWDSEAHGTPICQEDMIGGQLFFSLLVLDSLHRLGIHMSTEGAEAYYYAWRVV
                     GAILGVDQDAVPRTLEEARQFQDLYMLRHMGPSDEGAHLTRQLIDLYEEVVPGTFFDPI
                     VSALVRYLIGDTCADWLRVPRTAWDSVVKTAPTLLGVLETIEDRSPLGAWALDRLGHLT
                     TIFELSSLTRGRVMHYAIPEQLKKDYGVTGAVPRTHRWTPPAPTVTP"
     gene            complement(10001..11053)
                     /db_xref="GeneID:69762051"
                     /locus_tag="FYC74_RS18310"
     CDS             complement(10001..11053)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762051"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978297.1"
                     /locus_tag="FYC74_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_194276771.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.5e-34, bitscore:
                     118.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDSWDRAAFKARVDDTLSAFLTAETAELLSIDPDLKPVAEQVRL
                     AAAHGKRLRAAFCYWGWRAAGQPDSEALLRAAASMELVHAAATVHDDLIDDSPRRHSRP
                     TAHVALLEPVRGRPGAAAAARSLAMLVGDLLMALAGQLFISSGLPAAYLARARPLWSAL
                     ARELIAGECLEILRTAGPPDTQDSLKVIRYKTAKYTVEQPLLLGGLLAGASRRLREGYS
                     AYGLPLGEAFQLRDDLLGLFGDPDRTGKAALDDVRGHRPTALLAETWKAADGTQREHLH
                     ALLGRDDLDDRHLATVRSLMTELKAPQRIEHMITARAEAAARTLHEMDLPRQARCALAD
                     LARSATDRLH"
     gene            complement(11046..11336)
                     /db_xref="GeneID:69762052"
                     /locus_tag="FYC74_RS18315"
     CDS             complement(11046..11336)
                     /codon_start=1
                     /db_xref="GeneID:69762052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027208.1"
                     /locus_tag="FYC74_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase"
                     /protein_id="WP_194276772.1"
                     /transl_table=11
                     /translation="MTQPSRQGGGLDEQAVLLVAGLADLAFSTIGSATSALKGLVRRSD
                     AADLARDAEQDLMARGRLTLDRYSAQPAHLEVLAQHVVTRSAASADTDGDD"
     gene            11538..12020
                     /db_xref="GeneID:69762053"
                     /locus_tag="FYC74_RS18320"
     CDS             11538..12020
                     /codon_start=1
                     /db_xref="GeneID:69762053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013001998.1"
                     /locus_tag="FYC74_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5990 family protein"
                     /protein_id="WP_228123404.1"
                     /transl_table=11
                     /translation="MHIRIDAVDLPGLVCPVPVGGRLSEYRNVHVAVQRRDRPGELLAP
                     QPGDARSASWTLECSTRVSPDGIKVQGPYVQDRLGHRFVYLSWGTVDDAGTFTMFRRAK
                     LMLDAVPADVLAAARDGLLVGRLGLTDAQGGPLCARVRPPDITWTAERAGQGDTPR"
     misc_feature    complement(11550..11564)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            complement(12118..12642)
                     /db_xref="GeneID:69762054"
                     /locus_tag="FYC74_RS18325"
     CDS             complement(12118..12642)
                     /codon_start=1
                     /db_xref="GeneID:69762054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382947.1"
                     /locus_tag="FYC74_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_224291919.1"
                     /transl_table=11
                     /translation="MRSRRIVTAAIAAAFVMLPAGTALAGSGPAPAPSENSASKSTAAT
                     PEGNPLSAKAQAGGVCDDAHQIGKTGYIKRDGTTIASVKQFYSPECKENYSYVWLWQDF
                     VDQEDDYTVSAGVWSYTQNHEFGTESWEADNGQEYWSGGTDTVSDCTSAGGAVEPAGSD
                     TTYSGTTDTRC"
     misc_feature    complement(12787..12805)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.71"
                     /tool="antismash"
     misc_feature    complement(12788..12804)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.59"
                     /tool="antismash"
     misc_feature    12802..12815
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.14"
                     /tool="antismash"
     misc_feature    complement(12973..12983)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            12983..14221
                     /db_xref="GeneID:69762055"
                     /locus_tag="FYC74_RS18330"
     CDS             12983..14221
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762055"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475082.1"
                     /locus_tag="FYC74_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase"
                     /protein_id="WP_194276775.1"
                     /transl_table=11
                     /translation="MSTFSAASRSGRRVGLPALVTASVLAALATTVPAASARDAGPPAG
                     GECGGQEQTRRAVRLLTERDGIPGAAVLVTDPATDGRCGRWTEAAGTADLRTGRPMTSA
                     DRLRAGSVTKTFTAALVLQLVAERRLSLDEPVERRLPGLIQGHGHAHGHGYDGGQITVR
                     QLLQHTSGLPDYLEAPEWEDYEQLRYRRFEPRELVRRALELPPPQGAWHYATTNYLVLG
                     LLVREVTGRSPEAEIDRRFIKPLGLHDTYWPGDDPRVQGPHSRSYFVDGDGRRVDGTDW
                     NMTFAGAGGALVSSPGDLTRFAGALLGGRLLPAAQLAEMRRTVEADPDRVWPGARYGLG
                     LISTPLSCGGTWWGHAGTVPGGHRALVAVGPGGRSAAVALNTVPDSLPAELDFLDVVDK
                     SLCGDRHSERNSA"
     gene            14218..15783
                     /db_xref="GeneID:69762056"
                     /locus_tag="FYC74_RS18335"
     CDS             14218..15783
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (111-482). E-value:
                     1.2e-16. Score: 53.1. Matches aSDomain:
                     nrpspksdomains_FYC74_RS18335_Abhydrolase_1.1"
                     /codon_start=1
                     /db_xref="GeneID:69762056"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007502817.1"
                     /locus_tag="FYC74_RS18335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_194276776.1"
                     /sec_met_domain="PF00561 (E-value: 1.5e-21, bitscore: 75.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRFSRHRPGARTAAGIALCLVGAFGAAATPAAATGTAPVTADPL
                     ARYHRQHLDWKSCLLGPDDETGRELQQAGAQCADVTVPLNYAEPDGRTLTVAISRIRAT
                     DTAHRVGALLLNGGGPGGQTIGDPPWVRAAMRQTGERYDVVGVDPRFVGRSTPLDCHWP
                     TGSSIRGAGTDRAGFDRSVAMAEDLADRCRTSQGEVLPYVTTRNTARDLDVVRAALGER
                     RISYLGYSYGTYLGQVYATMFPGRTDRVVLDGVLAPDRYTPRLLRGTEPANRHALKGWA
                     AWAAARDAAYGLGRTPDRVLATVDRVQAAAARTPLSIGGHRVDDRMVPVLLLNGLSQDN
                     DAAYGDFALAVRDMRRAADGRTVAPSPWLAETLGFLMSGSDSAYGSVQTAILCGDVSAP
                     RSPEVYWRDVQRSRAKDPLFGPVSNNITPCAFWDPPRERPTAIRGDLPALLVNATGDPR
                     TTYDSARSLRRMWPSSRLVTLRGADQHAVYGIFGDSCTDATVNSYLSTGRLPATDVTCD
                     RSSG"
     aSDomain        14551..15663
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FYC74_RS18335_Abhydrolase_1.1"
                     /evalue="1.20E-16"
                     /label="FYC74_RS18335_Abhydrolase_1.1"
                     /locus_tag="FYC74_RS18335"
                     /protein_end="482"
                     /protein_start="111"
                     /score="53.1"
                     /tool="antismash"
                     /translation="ALLLNGGGPGGQTIGDPPWVRAAMRQTGERYDVVGVDPRFVGRST
                     PLDCHWPTGSSIRGAGTDRAGFDRSVAMAEDLADRCRTSQGEVLPYVTTRNTARDLDVV
                     RAALGERRISYLGYSYGTYLGQVYATMFPGRTDRVVLDGVLAPDRYTPRLLRGTEPANR
                     HALKGWAAWAAARDAAYGLGRTPDRVLATVDRVQAAAARTPLSIGGHRVDDRMVPVLLL
                     NGLSQDNDAAYGDFALAVRDMRRAADGRTVAPSPWLAETLGFLMSGSDSAYGSVQTAIL
                     CGDVSAPRSPEVYWRDVQRSRAKDPLFGPVSNNITPCAFWDPPRERPTAIRGDLPALLV
                     NATGDPRTTYDSARSLRRMWPSSRLVTLRGA"
     gene            complement(15832..16659)
                     /db_xref="GeneID:69762057"
                     /locus_tag="FYC74_RS18340"
     CDS             complement(15832..16659)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (13-129). E-value: 7.2e-12.
                     Score: 37.5. Matches aSDomain:
                     nrpspksdomains_FYC74_RS18340_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GeneID:69762057"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048838.1"
                     /locus_tag="FYC74_RS18340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_228123405.1"
                     /transl_table=11
                     /translation="MSTESAESTRQGRTALVTGASSGIGAAYARRLAARGWDTVLVARR
                     AQRLDDLARRLREEGTGTRVETLVADLSDPADLARVADRAAGDDIGFLLNNAGINGYGP
                     FTDLDPALLRKVLDVNVLAVTVLARSAVAAMRERGRGTLVNVASQLAFAGSLPPGPLPE
                     RAVYGGTKGYVVTFTRTLAAELAGTPLHVQVLCPGLTATEFHRSRGEEPVEGREQQVHE
                     DGGMPVHQVVDASLAALDTGDVVCVPGLRDTTPIDRLAEAERTLREAARRGTP"
     CDS_motif       complement(16228..16281)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FYC74_RS18340_0002"
                     /evalue="6.70E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="FYC74_RS18340"
                     /protein_end="144"
                     /protein_start="126"
                     /score="-0.4"
                     /tool="antismash"
                     /translation="LARSAVAAMRERGRGTLV"
     aSDomain        complement(16273..16620)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FYC74_RS18340_PKS_KR.1"
                     /evalue="7.20E-12"
                     /label="FYC74_RS18340_PKS_KR.1"
                     /locus_tag="FYC74_RS18340"
                     /protein_end="129"
                     /protein_start="13"
                     /score="37.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGASSGIGAAYARRLAARGWDTVLVARRAQRLDDLARRLRE
                     EGTGTRVETLVADLSDPADLARVADRAAGDDIGFLLNNAGINGYGPFTDLDPALLRKVL
                     DVNVLAVTVLAR"
     CDS_motif       complement(16552..16614)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FYC74_RS18340_0001"
                     /evalue="3.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="FYC74_RS18340"
                     /protein_end="36"
                     /protein_start="15"
                     /score="13.4"
                     /tool="antismash"
                     /translation="LVTGASSGIGAAYARRLAARG"
     misc_feature    16614..16628
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
     gene            complement(16667..17062)
                     /db_xref="GeneID:69762058"
                     /locus_tag="FYC74_RS18345"
     CDS             complement(16667..17062)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762058"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008736892.1"
                     /locus_tag="FYC74_RS18345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_194276777.1"
                     /transl_table=11
                     /translation="MDTVRISPPHRELLDQVLDKWSLSVLSELCERPCRFNELRRAIPQ
                     VTQKSLTATLRRLERNGVVAREVVSTRPVAVSYRITPLGKTLRPPIDVLLTWAADHMPA
                     ITRAREAFDAPGGVPGTDRSESSESER"
     misc_feature    complement(17055..17070)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     misc_feature    complement(17094..17107)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.7"
                     /tool="antismash"
     gene            17153..17563
                     /db_xref="GeneID:69762059"
                     /locus_tag="FYC74_RS18350"
     CDS             17153..17563
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388516.1"
                     /locus_tag="FYC74_RS18350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RidA family protein"
                     /protein_id="WP_031046057.1"
                     /transl_table=11
                     /translation="MAVRHFTPRGLLQPTPYHHVAVGTGTTHVHVSGQIARLADGTPVA
                     PGDLAGQVSQALRNTSVGLAGAGASFADVLRLTFYVTGWRPEKIDAFMAGVEAVADEIG
                     LPRPMPPASLIGVDHLFEPDVLVEVEATALVG"
     gene            complement(17651..18262)
                     /db_xref="GeneID:69762060"
                     /locus_tag="FYC74_RS18355"
     CDS             complement(17651..18262)
                     /codon_start=1
                     /db_xref="GeneID:69762060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061141.1"
                     /locus_tag="FYC74_RS18355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_194276778.1"
                     /transl_table=11
                     /translation="MSFTVPAVAAPTAPVAPRPSADVANLATYVSFGLAYVLGHGSAAL
                     SRGDAPLLDLPGWLPMALLGAGLAAGTVLATLAALRAQRATTDPAAVRTGQLLGALWVT
                     AFAALFLLITGLAAAVDNPDLQTLLWPTGSGFVVGVIYVAEGATRRNTLHYALGTWLAL
                     TSTAALLLGDPAFYWVLTLAGGGAYALAALLEHRRLARRG"
     gene            complement(18437..19495)
                     /db_xref="GeneID:69762061"
                     /locus_tag="FYC74_RS18360"
     CDS             complement(18437..19495)
                     /NRPS_PKS="Domain: PKS_ER (26-348). E-value: 5.1e-43.
                     Score: 139.3. Matches aSDomain:
                     nrpspksdomains_FYC74_RS18360_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GeneID:69762061"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718541.1"
                     /locus_tag="FYC74_RS18360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="medium chain dehydrogenase/reductase family
                     protein"
                     /protein_id="WP_194276779.1"
                     /sec_met_domain="ADH_N (E-value: 5.6e-05, bitscore: 21.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.2e-21, bitscore:
                     75.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHHTATPTTVTATEVVLPGKVEPEGLEVRTHELPAPAKGQVVLR
                     MEATGVSFAEQQMRRGKYFDQPPFPFVPGYDLVGTVVGTGPGADPELVGRRFAAVTKTG
                     AWASHLVVDAADLMPVPDGIDPAAAETVIVNGVTAWQMLHRTAKVRAGGTIVVLGANGG
                     VGSTLVQLARHAGITVIGTASPRHHEALRQLGVSPVDYRDPDMYARIRELAPDGVDAVF
                     DHIGGPAIEDSWQLLRRGGTLVSYGTAASKDEEGNSQAPVLKLFARLGAWNAMPNGKGA
                     HFYNLWAGKRRCQTSWQRRMTEDFTQVLRLVADGSLTPQIAATFPLADTVAALRLAESR
                     TVAGKVVIVPGK"
     aSDomain        complement(18452..19417)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FYC74_RS18360_PKS_ER.1"
                     /evalue="5.10E-43"
                     /label="FYC74_RS18360_PKS_ER.1"
                     /locus_tag="FYC74_RS18360"
                     /protein_end="348"
                     /protein_start="26"
                     /score="139.3"
                     /tool="antismash"
                     /translation="LEVRTHELPAPAKGQVVLRMEATGVSFAEQQMRRGKYFDQPPFPF
                     VPGYDLVGTVVGTGPGADPELVGRRFAAVTKTGAWASHLVVDAADLMPVPDGIDPAAAE
                     TVIVNGVTAWQMLHRTAKVRAGGTIVVLGANGGVGSTLVQLARHAGITVIGTASPRHHE
                     ALRQLGVSPVDYRDPDMYARIRELAPDGVDAVFDHIGGPAIEDSWQLLRRGGTLVSYGT
                     AASKDEEGNSQAPVLKLFARLGAWNAMPNGKGAHFYNLWAGKRRCQTSWQRRMTEDFTQ
                     VLRLVADGSLTPQIAATFPLADTVAALRLAESRTVAGKVVI"
     misc_feature    complement(19565..19580)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.78"
                     /tool="antismash"
     gene            19832..20605
                     /db_xref="GeneID:69762062"
                     /locus_tag="FYC74_RS18365"
     CDS             19832..20605
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69762062"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975226.1"
                     /locus_tag="FYC74_RS18365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_194276780.1"
                     /transl_table=11
                     /translation="MARHGAGRGWYGKVVGGALGVTLLAVGASVWTAQADSVGSASPKP
                     SASAAPGGAAEPVDVSIVHASDAGARGVNITIDDGPDPTWTPQVLDLLDEYGVKATFCV
                     TGVQAQTYPDLVQQVVAAGHRLCDHTVSHDTAMDKKPESYQSKEILDAERMIIKASGGV
                     RPLYYRAPGGAFTPYSRKLAASHGMRPLGWNVDTKDFERPGTDAIVETVQRELSNGPTL
                     LFHDAGGDRTQTVEALRRVLPWLKEQGYSFGFPVR"
ORIGIN
        1 ccagctcggc ggcgacggcg cctggcagcc gacggtcggc ctctccatgc tgatcatgtc
       61 gatcacggac gccccgcgcc tgctcgtcgc gatgttcgcc ggcggcgacg cgcccttcgt
      121 ccagatcctc ggctgggcca cctgggtcgc gggcggcgtc ctgctgaccc tgatggtcag
      181 ccgctcccac gacctcccct ggccgaaggc gctcggcgcg tccgccatcc agctgatcgc
      241 cctgctgtcg atcgtgaagc tgggcacgtt ctagctctgc ccgcgtacga cgagggggga
      301 ccggcgcgcc ggtcccccct cgtcttgccc tctcccgccc gtcaggcgtc gagcacctgc
      361 ccgtcccgcc gtacgacggg cggcaggaca ctccacggga agttgatcca gtcatcggtc
      421 cgcttccaca cgtactcgca ctggacgagg gagtgggact tctcgtagat caccgcgctg
      481 cggacctcgg cgacggtgtc gaggcagaag tcgcgcacca gcttgagggt cttgccggtg
      541 tcggcgacgt cgtcggtgat gaggaccttc ttgtcggaga agtcgatgac gttgggcacg
      601 ggcgcgagca tgacgggcat gtcgagcgtg gtcccgaccc cggtgtagaa ctccacgttc
      661 acgaggtgga tgttcttgca gtcgagtgcg tacgccagcc cgcccgcgac gaagacgccc
      721 ccgcgggcga tggagagcac gacgtcgggc tcgtacccgt cgtcggcgac ggtctgcgcc
      781 agctcacgca cggcggcacc gaactgctcg taggtcaggt tctcccggac atcactcatg
      841 cgcgcgccct gctcgtcact ggcttcatac ctgggtccga tggaagttga ggtaggagcg
      901 ggaggcggtc ggcccccgct gcccctggta acgggacccg tagcgctcac tgccgtacgg
      961 atgctcggcc ggcgaggtga gccggaacat gcacagctgc ccgatcttca tccccggcca
     1021 cagcttgatg ggcagggtcg cgagattgct cagctccagc gtcacgtgcc cggagaaacc
     1081 cgggtcgatg aacccggccg tggagtgcgt gacgagcccg agccgcccga gcgagctctt
     1141 cccctccagc cgcgaggcca ggtcgtcggg gagcgtgatg acctcgtacg tactggccag
     1201 cacgaactca ccggggtgca ggatgaacgg ctcgtccccc tccggctcca cgagccgggt
     1261 cagatccacc tgctcgacgg aggggtcgat gtgcgggtac cggtggttct cgaacacccg
     1321 gaagtagcgg tcgaggcgca cgtcgatgct cgacggctgc accatggagt cgtcgagcgg
     1381 atcgatccgc acccgcccgt tgtcgatctc ggcacggatg tccttgtctg agagaagcac
     1441 gccccgagga tacgcaaggc gcgcggagca gcgacaaccg ccgccgcacc gcgcgccctc
     1501 tcctgctcgg cttccctgct ggggcaccct gctcgggcgc cctgccgcta ccgcttgccg
     1561 gaacccaccg gcacggcact ccgcagccgc gcacaccgcg gacatcggac gagccgaccg
     1621 gggccgagtc gctcggcctg ctgcatcggg aacgaggtgg cggtgaacac gtgcccatcg
     1681 gcacagcgga cgacggtgcg ctccatcaag tccttcaagt cccttcccca agagccgcgt
     1741 ctggctgact accctgacga caaaagccac agtacgggat gaaagagacg actctccagg
     1801 cggcactccg ccctcgcaca caccctctgg agcgccccac cgtacgcccc gacccgaccc
     1861 cccgacagcc gcgtcccacc ccctgaaacg accggcggcc cacggccgaa gaccgggggc
     1921 cagcgatggg gtagagtaag cgaacgtcca gacaccgacc gtggtcggcg tctcgcgcgg
     1981 gtgtagttta atggtagaac atcagcttcc caagctgaga gcgcgagttc gattctcgtc
     2041 acccgctcca tggctgaggc ccaggtcaga gacctgggcc tttttgctgg ccgggctgag
     2101 ccgcgcgggc agtgcgcgag gcccagtttc cacgtacgca tggaacggtc tgtcaatttg
     2161 ggcacgcagg tggatccttg tgccggatac cagcgcgggt cgttgctgcg cacccgtgcg
     2221 tacgcagaca atgtgagcgg tctttgacgt ctctgcgacc ggacttcctg cttgaaggca
     2281 acgatcacgc ggcttaacag aagtctcagg cagcggatgc acccgccccc tacgacagcc
     2341 tctcgccacc cggaatgcac cacccgtcgg gcgacgaagg cgtgtcaggc gacgtcgtgg
     2401 acgttgtgct cgttcaggtc ggatgcgtgc cgggcgacag tgccgtagtc ggcatcgtcg
     2461 tggaggacag tcaggccgtg gtgcgcggca gtggctgcga tgacaaggtc tactgccgag
     2521 gcactgcggt gctccccggc ctgagccata cggtgttgca ccgcgctgat ccaacgccct
     2581 gcattcttcg gcaccgccgc atcgggatag aggtcggaga acatttccgc gatctcgtcg
     2641 tactcgctgc gattccgggc gctgtacagg aactcggtgc gttgcacgta gcaggatgcg
     2701 atggctccgg cgtcgatcgc gtcgtgccag gccgattgca ggttcgcatc gcggagcagc
     2761 ctgaccaggc cggacgtatc gagcaggtac atcaccggct gcgcttctcc accctgtgca
     2821 ggcgctcggc gtcctcgacg gcaccccact cgcgggcacg ctcgaagtga cggctgatgc
     2881 gcgccgcacg ttcctgctgc tcggcgtaga aatgcagggc gagattgacc gcctccttct
     2941 tggtccggac atgggccaga gccatggcgc gctccagggc gtcgtcatcg atgtcgatct
     3001 gggtcacgga cataacctcg cctcccaggc aatgttggtg atgtacatag aagaatacgt
     3061 caccaacatc gaccgagcca catgccggcc ctgccccgcg tatggctgta ccggacgccc
     3121 cacgggctcc tcacgcgtgc ctcgcctcgg gcacgcagtg agaagcgaac gtgttcgtta
     3181 cgatcggttc atgactgcaa ggagagagcc gatcagccgc cgggagcggc ccgcgaaggc
     3241 tgcgctgtcc cggcgctgga tcgtggacac cgccgtgcgg gtcatgcgcg ccgaggggct
     3301 ggagaaggtc accatgcgcc gtctggccaa ggagctggac accggcccgg cctcgctgta
     3361 cgtctacgtg gccaacaccg cggaactgca cgcggccgtg ctcgacgccc tgctgggcga
     3421 ggtcgacctg gccggcggag gcgcggggga cgactggcgc gggcagctcc gcgccgtact
     3481 ggcctcctac acgtccgtac tgttcgcgca tccgcagctc gcccggtccg cgttggtggc
     3541 acgccccagc ggcgtcaact acctgcgcct ggtggagcgc gtcctggacc tgctgtcccg
     3601 cagcggcgcc tcccgtgaac aggtcgcgtg gggcgtggac aagctgctcc aggacgccac
     3661 ggccacggcg gccgagcagt cggcgcagga acacgacccc atgaccgagg acgactggaa
     3721 cgccaccacc cgggccctgc gctccgtgga cgaggcccat ccggccatca gggcgcacat
     3781 gcccgccctg gtcagcggct cgcccgagga ccgtatgggc tggagtttcg acgttctggt
     3841 caacggcatc acgcgtaccc ccgtccccgg cacggacggc tgaagcctgt ctcggcggcc
     3901 gtccgcccgc gaacgggggg ggcggtcgta tcggggcgta atcactggcg aacttgtacg
     3961 tgacgaacat gttcgttacc gtggaagtgt ccggtcttcc cgagccgcag gtttcccgcg
     4021 tactcggtca gtcagcagga gggcccatga gtacccatca ccccgtcgcg atcatcggcg
     4081 gaggcctcgg cggcctcacc gccgcccgcg tcctgcacgt caacggcgtc cgggccgccg
     4141 tcttcgaatt ggaggcgtcc gccgcggccc gcacccaggg cggcatgctc gacatccacg
     4201 aggagaacgg ccagaaggcg ctgcacgccg ccggcctcca cgaggacttt ctcaagatcg
     4261 tccacggggg cggccaggag atgcgcctgg tcggcccgga cgccaccgtt cacgttcgcg
     4321 agcaggacga cggaaccggc gcccgcccgg aggtggaccg cggcgacctg cgccacctgc
     4381 tcctgaactc gctgcccgac ggcacgatcc gctggggcaa gaaggccacg accctccggg
     4441 cgctgggcga cggccgccac gaggtgacgt tcgccgacgg ctccaccgtc accaccgacc
     4501 tcctgatcgg cgccgacggg gcctggtccc gggtacggcc cctgctctcc gccgccacgc
     4561 ccgcctacac cggcatctcc ttcgccgaga ccgacctgca cgacgccgac gcccggcacc
     4621 cgcgcggcgc cgccctcgtc ggaggcggct tcttcatcag cctgagcgag gggcgcggtt
     4681 tcctcgcgca ccgcgagacc gacggcagcc tccatgtcta cgccgcgctg aaggccgacg
     4741 aagactggct ggacaccgtc gacttcaccg acctcaccgc cgccaaggcc gccgtactcg
     4801 ctcgcttcga gggctggcac gaggacctgc gcggcctggt cgccggcgcg gacacggtca
     4861 ccccgcgccg catccacgcg ctgcccgtcg gacaccgctg ggaacggacc gcgggggtga
     4921 cgctcctcgg tgacgccgcc cacctcatgt cccccttcgc cggcgagggc gccaacctgg
     4981 ccatgctcga cggtgccgaa ctcgccgaga cgatcgccgc tcaccccggc gacaccgagt
     5041 ccgcgctcgc ctcctacgag caggccctct tcccgcgcag cgaggcgtcc gcggtcgagt
     5101 ccgcggccag cctggagacg atgttcggcg accggggact ggagcagatg atcgagttct
     5161 tcaccgccgg accggcggcc gggtgaccgc cggcgccccc cgcagacagc cggttctgtc
     5221 ccggcgtcgg gcgttacgcg cgggggcttg acgccgcggg agacgagggc ggctcggtcg
     5281 tcgtggcggg cccgtcgacg cgggcctcga agcactcgcg ctcgccgtcg ggcgccgcgg
     5341 gccggaagca ggcccggacg gtgctgccgg gaccgacttc cgtcatctcg gtgtagacga
     5401 aggccgccgc gtcctcctcg ttcctgatgc gcacgtcgtg ggtcgggccg cccgccgtga
     5461 cgtccacccg gtcgccgatc tcggtccccc aggtccgcac ccagctcgca ccgcacttcg
     5521 tgctgtggcg cagctcgacg tgggcgccgg tggccgtgcg gtgcgaggcg agggtgtcgg
     5581 ggccgatgcc gcagatcagg cgcatcgggt cccggccctc gcaggcggcg ccctggcatt
     5641 ggggagcgag ggagaacggg acggaggccg tcggcggttc gtcctcccgc gcctccgagt
     5701 ccggcagcag gaggaacagc agggccgcgg cgccgccgac gatcacggtg tacgccgatg
     5761 ccagcgccag cagaagcctg cccctggcgc gtcgccggcc ggccccggtg ggcggtggcg
     5821 cctgctgggg cggtgactgg ggcggctcgt ccgtggaagg ggcgggggcg gcgggcgcgg
     5881 ggggcgtcgc gcgtccgctc cagcgcgact cggcgatctc ccacagggcc agcagtcgcc
     5941 cgtccggttc gttcgcgagt cggcacaggt cccgtacggc ctggcgaggg ggcaggctct
     6001 tgccgttgag gtaacgctcc cacgaggact tgctgtacgg cgttcgctcc gcgagcgccg
     6061 ccaggctcag tcctgatccg gccttcagct ctcgcagggc cgcgaccagc cgggtgtgtt
     6121 ccgtggtcac tggggcgccc cctcccgcag ggcctgccag gtgggcgggt cgatgacccc
     6181 gttcacgatc agcccgccgc gcttctgcat gcgctcgacc gctcgccggg tcttcggacc
     6241 gaagacgccg tcgatgtcgc ccggttcgga gcccgcccgt tgcagcaggc actgggcctc
     6301 ggccacttcg agccccatct gggtgttgga caggaggatg tcggtggtcc ggctcaggcc
     6361 cgcgtaccag cgtccgtcgc gctgctccag ctcgcaggtg tagatgaccg gcaccatgga
     6421 ctccgacacg gtggccacgg ccgtcgcggc gacaccggcg cgttcgtccg cgagctgggc
     6481 acgggcctcc gtgagccgca cggccagcag cagcgccgcg gtgacggaca gcgccgtcac
     6541 cacggccgcc accgtgaccg cgacgcgcag gtgacgcccc tgcgggtggt gctcggtggg
     6601 ggcgtgttcc ggtggcgcgg ggccatcatc gggggcgggg gcggtggcgg tgaccgcccg
     6661 tccttccgac cagcgttggg cggcgatctc gtgcagcacc agcaagcggt gcggattgtc
     6721 cccgccgacg cgggccatcg actcgacggc ctcgcggggc ggcagagacc tgccgttcag
     6781 ataccgctgc caggacttgg cgctgtaccc ggtcttcgcg gccagtcggc gcttgctcaa
     6841 ctcgctgcgg tccttgagcc cgcgcagccg cacgatcagg tggcggacgt ctggatgcag
     6901 ttctgcgggc agttccctcc agtgcgacac gcttctccca ctcgcgttcg ggaccccccg
     6961 ggcccgcccc cgtacctcgg tctcattctg catcagccat cacgggtgta cagcgcggca
     7021 ctcgggcccg gcgcggctcc gccctgtcgc ggacgcagcc gttccgtccc ggcgcggtcc
     7081 cggcgcggtc ccgctgcggg gacgcgcagg gcgacgtccg tgcaggtcaa cgcgcgggac
     7141 gtctcgggac gaggccactt ccgcgtgggc tgtggtcagc ggtcgcgccg accccgcacg
     7201 ctcatggggc cttcaccgcc gcggccgggc tcggcgccgg cggcaggtat cccgttcgac
     7261 gcacaactga gcaaaggaac aggtcattga agaagcgcgt gggtccgcga agctggctga
     7321 ccgccggtgt ggtcgcctcg gttctggccg gggggtccgt gttcttcgga gcgtcccccg
     7381 cggcggcagc cgcctgtggc gcgtcgctca gcgtcaaaac ggcgggagct tctgccgcgt
     7441 gggacgtggc gtgcgacgcc ggccacatcc gcgtcgtcgg atgggtcaag gacaccgaca
     7501 acgacggcca gtgcgcccga gtgcgcgtgg agtacgccga cgggcacaag tggtacagcc
     7561 cgcaggcgtg ccccaaggga acgaaggtca gcttcgggtc gccctggagc gacaccaagt
     7621 cccagatcat caacgcgtat ctgtacgagt tcgacgtctg agtgcgcgac gggcggcccc
     7681 gctgctgccc ggagaaggct gatcgaggac tccggggtgt gcatcgtctg gccccgcccg
     7741 gggtcctggg aagagaccac gaaagtaggg aactcggagt gaaggcttca cggaagatcc
     7801 gcacgcttac cgccggcgcg gcggcctccc tcgttctggg cgtcggtgcg accctgctga
     7861 ccgtcggccc tgccgcggct gccggctgcg gggccaccct gaaccccaag acgtccggcg
     7921 ccgaggcgtt ctgggaggtg aagtgcgtcg gaacccagcg cgtaggcatc gccggatggg
     7981 tgaaggacac cgacaacgac ggccagtgcg ctcgcgtcaa ggcgaccttc ccgaacggga
     8041 cgacctacta cagcccgcag gcctgcccca agggcaccaa ggtgaacttc agctccggct
     8101 ggcgcagcgg agcgctcgtc gacgcgtacc tgtacgagtt cgacgtgtga cgccctgagc
     8161 gggacgcgga ccgtacggca gccggggcgg gggcgggcag gatgttcctg tccggccccg
     8221 cgccggttgc cgccggtgcg accggggttc caccgcgccg actcggcagt acggtgaaaa
     8281 cgtgacctcc ttaccggaag aatcgccgtc gctgatccgt gaagacgatc gtgatgcagc
     8341 cgtgcggcgc ctgcaggagg cgtacgccga agggctcatc gcccacgagg tgttggacga
     8401 gcgccttcac caggtgctca gcgccacgac gcgcggcgca ctcgcgtccg ctctggtctc
     8461 tctcccggag gagcccccgg cacgcacggc cacgatcggc gccgccggcg ggcggatcaa
     8521 gcggcacggc gcgtggcggg tgcctcgggt cctcaaggcc gagtcggcat acgggcgggg
     8581 ccggaatcac ggtgcctcgt gacgcggttg tcgacgtcga aggcctgagc actggctgga
     8641 aggacctgcg ctacaaggtc ccgcggcgtt cccggaccgg cgggccggtg attcgcgtgt
     8701 acggggccat gggatacggg cgcctcagga tccgccacag cctgcgttga ggccccaccc
     8761 ggtgccgacc acccggtgcc gacctgtcgg cgccgccctg ccggtaccgg tcagggcgtg
     8821 acggtcgggg caggaggcgt ccacctgtgg gtgcggggta cggcgccggt gacgccgtag
     8881 tccttcttca gttgttccgg gatggcgtag tgcatgacgc gtccgcgggt gagtgaggac
     8941 agctcgaaga tggtggtgag gtgtccgagg cggtccaggg cccaggcacc gagcggggag
     9001 cggtcctcga tggtctccag gacgccgagc agggtggggg cggtcttgac cacgctgtcc
     9061 caggccgtgc ggggcacccg gagccagtcg gcgcaggtgt cgccgatcag gtagcggacg
     9121 agtgcggaga cgatcgggtc aaagaaggtg ccggggacga cttcctcgta gaggtcgatc
     9181 agctgccggg tcaggtgcgc gccctcgtcg gacggcccca tgtggcggag catgtagagg
     9241 tcctggaact gccgcgcctc ctccagtgtc ctgggtacgg cgtcctggtc gacgccgagg
     9301 atggcaccga ccacccgcca tgcgtagtag tacgcctcgg ccccttcggt ggacatgtgg
     9361 atgccgagcc ggtggagact gtccaggacg agcagggaga agaacagctg cccgccgatc
     9421 atgtcctcct ggcagatcgg cgtgccgtgc gcctcgctgt cccagcggtt ctcccgcttg
     9481 aggtggtggc ggatggaggc gtgcagcaga cggaccttct gcgcggcggg gatgaaccgg
     9541 ccgcccgcct cgaaggcgtc gggctgcatc aggtagacgg tgaactggcc ggtctccgcc
     9601 atccgtttgg acggatagtt cagcccgtgc gtggcggaca gcagtttcgc cacgtgcggg
     9661 acgacgtagc aggccggcat cgcggcgaag gacagcgcgg tggagatgtg cacgttgttg
     9721 tcgatgaaga acagccgtgc cttctccatc tccccccagt ccacccacgc cggcggcaca
     9781 ctggtggcct gcaggtactc ccgggctact tccggcaggc cgtcgggcag gggcgtaccg
     9841 gcggtggaca cgtagcgcat cagggagttg aacgtgccca cctccccgcg ttcgaacagg
     9901 gtggccacga cggcgtcggc gagttcgtcg cccgtctgcc gcagcgagtc catggatgct
     9961 tcgctgtagg tcatggtgtc tccgggtggt ccgtgcgtgg tcagtgcagg cggtctgtcg
    10021 cggagcgggc gaggtcggcc agggcgcacc gggcctggcg cggcaggtcc atctcgtgca
    10081 gggtccgggc ggctgcctcg gcgcgcgccg tgatcatgtg ctcgatgcgc tggggagcct
    10141 tcagttcggt catcagcgag cgcacggtcg cgaggtggcg gtcgtcgagg tcgtcgcgtc
    10201 cgaggagcgc gtgcaggtgc tctcgctggg tgccgtcggc ggccttccac gtctccgcca
    10261 gcagtgcggt gggccggtgg ccgcgcacgt cgtcgagggc ggccttgccg gtgcggtcgg
    10321 gatcgccgaa gaggccgagc aggtcgtcgc gcaactggaa cgcctcgccc aggggcaggc
    10381 cgtaggcgga gtacccctcc cgcaaccgcc gtgacgcacc cgcgagcagg ccgccgagga
    10441 gcagaggctg ctcgacggtg tacttggcgg tcttgtaccg gatgaccttc aaggagtcct
    10501 gtgtgtccgg tgggccggcg gtgcgcagga tctccaggca ctcgccggcg atcagttcac
    10561 gggcgagagc cgaccacagc ggccgggccc gggccagata ggcggccggc aggccgctgg
    10621 agatgaacaa ctgcccggcg agggccatca gcaggtcacc caccagcatg gccagcgaac
    10681 gcgctgcggc tgcggccccg gggcggcctc ggacgggctc cagaagggcg acgtgcgcgg
    10741 tggggcggct gtgccgtcgg gggctgtcgt cgatgaggtc gtcgtggacg gtggcggcgg
    10801 cgtggaccag ttccatggag gccgccgcgc gcaggagagc ctcgctgtcg ggctgtccgg
    10861 ccgcccgcca tccccagtag cagaacgccg ctcgcagcct cttgccgtgc gcggcggcga
    10921 gccgcacctg ttcggcgacc ggtttcagat cggggtcgat cgagagcagt tcagcggtct
    10981 ccgccgtcag gaaggcggac agggtgtcgt cgacgcgggc cttgaaagcg gcccggtccc
    11041 aggagtcaat catcgccgtc cgtgtcggcc gaggcggcag agcgggtcac cacgtgctgc
    11101 gcgagtacct cgagatgggc cggctgggcc gagtaccggt cgagagtgag ccggccgcgg
    11161 gccatcaggt cctgctcggc gtcccgggcc aggtcggctg cgtccgagcg ccgcaccaag
    11221 cccttcaacg cgctggtcgc ggaaccgatc gtgctgaatg ccaggtccgc gagaccggcc
    11281 accagcagca cggcctgctc gtccaggccg cctccctgtc gcgacggttg ggtcatgctg
    11341 caactccccg agcagtcgga acttccgtgg acggcgaacc ggcgccccgt gggacagcat
    11401 gccgacatga gtacgacgag cacgcctcat taccgtattg agtgacaaga ccgaacagat
    11461 gtccacgaaa ctcgtcgcgg agcagggtcg cggggccccc gctccgcggc agccgggtcg
    11521 gcgggatgat gggccgtatg cacatccgca tcgacgccgt cgatctgccc ggtctcgtct
    11581 gcccggtccc cgtcggtggc aggctttccg agtaccgcaa cgtccatgtc gccgtgcagc
    11641 gccgcgaccg gccgggcgaa ctcctcgcac cgcagcccgg tgacgcgcgg tccgcgagct
    11701 ggacgctgga gtgcagcacg cgcgtctcgc cggacggcat caaggtccag gggccctacg
    11761 tgcaggaccg tctgggtcat cggttcgtct atctgtcgtg gggcacggtc gacgacgcgg
    11821 gcaccttcac gatgttccgc cgcgccaaac tgatgctcga cgccgtcccc gccgacgtac
    11881 tcgccgccgc gcgcgacggt ctgctggtcg gacggctcgg cctgaccgac gcacagggcg
    11941 ggcccctttg cgcgcgagtc cgccctccgg acatcacctg gaccgccgaa cgcgccggcc
    12001 agggggacac accgcggtga gggcggcgta gtcgcgcacc gacccccggg tcatcgaccc
    12061 gggggtcggt tgccgcccgg ccccgtccgg ggcgtgcggg cggaaggtga gcgggcgtca
    12121 gcagcgcgtg tcggtggttc ccgaatacgt ggtgtcgctc cccgccggct ccacggcgcc
    12181 gcccgcggag gtgcagtcgc tgaccgtgtc ggtgccgccg gaccagtatt cctggccgtt
    12241 gtccgcttcc cagctctcgg tcccgaattc gtggttctgg gtgtagctcc agacaccggc
    12301 gctgacggtg tagtcgtctt cctggtcgac gaagtcctgc cagagccaga cgtagctgta
    12361 gttctccttg cactcgggcg agtagaactg cttcacggag gcgatggtcg tgccgtcgcg
    12421 cttgatgtag ccggtctttc cgatctggtg ggcgtcgtcg cagacaccgc cggcctgcgc
    12481 cttcgcgctc aggggatttc cttcgggggt ggccgccgtg gacttcgacg cggaattctc
    12541 ggaaggcgca ggagccggtc cgctgcctgc gagagcagtg cccgccggga gcatgacgaa
    12601 ggcagcggcg attgcggctg tgacgatcct gcgtgaacgc acgaactttc ccctttgcat
    12661 gatgtgcggc gacctcagta cggctccatt ggtgcggggg tatctccttc cgtacgcgtc
    12721 cggaaggaga cggacaccag ccgaagggcc gattccgaca gtgaagaggg aaggcgtcgg
    12781 cgaggggttg cgacgcgttc ggatatttat tgttctctca gacggggagt tctttcgtcg
    12841 tcagtcggag ccgggctcct agcaagggag attccagctg tccaggaggg ctgctcccgg
    12901 gtttccggtc ggggctgcct ccgccgggag cgcctgcctg ccggagggac cgcggggccg
    12961 tccgtgccta ctgtgacgtg gcatgtcaac cttctcagcg gcttcacgga gcggcagacg
    13021 cgtgggactg ccggctctgg tcacggcctc cgtgctggcg gcactggcga ccaccgtccc
    13081 ggcggcgagt gcgcgggatg cgggtccacc cgccgggggc gagtgcggcg ggcaggagca
    13141 gacccgccgg gcggtgcgcc tcctcaccga acgcgacggc atccccggcg ccgcggtcct
    13201 ggtgaccgac cccgccacgg acgggcgttg cgggcgctgg accgaggccg ccgggacggc
    13261 ggacctgcgg accgggcgcc cgatgaccag cgccgaccga ctgcgcgccg gcagcgtgac
    13321 caagaccttc accgcggcgc tcgtcctcca actcgtcgcc gagcggcgcc tctcgctgga
    13381 cgagcccgtc gagcgacgac tgcccgggct gatccaggga catgggcacg cgcacgggca
    13441 cgggtatgac ggcgggcaga tcaccgtgcg gcaacttctg cagcacacca gtgggttgcc
    13501 cgactacctc gaagctcccg agtgggagga ctacgagcag ttgcggtacc gccgcttcga
    13561 gccccgcgag ctcgtccgac gcgctctcga actgccgccc ccgcagggcg cctggcacta
    13621 cgccaccacc aactacctcg tcctcggcct cctcgtccgc gaggtcaccg gccgttcccc
    13681 cgaggcggag atcgaccgcc ggttcatcaa gcccctgggg ctgcacgaca cctactggcc
    13741 cggtgacgac ccccgtgtcc agggccccca ctcccgcagc tacttcgtcg acggcgacgg
    13801 ccggcgcgtc gacggcaccg actggaacat gaccttcgcc ggggccggcg gcgccctggt
    13861 ctcgtcaccg ggcgacctga cccggttcgc cggcgccctg ctcggcggcc ggctgctgcc
    13921 cgcggcccaa ctggcggaga tgcggcgcac ggtggaggcc gaccccgacc gcgtgtggcc
    13981 cggcgcccgc tacggtctgg gcctgatctc gacgccgctg tcctgcggcg ggacgtggtg
    14041 ggggcacgcc ggaaccgtgc ccggcggaca ccgggccctg gtcgccgtag gccccggcgg
    14101 ccggagcgcc gccgtcgccc tgaacacggt gcccgactcg cttccggccg aactcgactt
    14161 cctggacgtc gtcgacaagt ccctctgcgg ggacaggcat tcggagagga attccgcatg
    14221 atccgcttct cgcgccatcg gcccggcgcc cgcaccgcgg ccgggatcgc cctgtgtctg
    14281 gtcggggcgt tcggcgccgc cgcgacgccc gcggcggcga ccggcaccgc ccccgtgacg
    14341 gcggacccgc tcgcccgcta ccaccggcag cacctcgact ggaagagctg cctgctcggg
    14401 cccgacgacg agaccggcag agaactccag caggcgggcg cccagtgcgc cgacgtcacc
    14461 gtcccgttga actacgccga accggacggc cgcaccctca ccgtcgcgat ctcgcggatc
    14521 cgggccaccg acaccgccca ccgcgtgggc gcgctgctgc tcaacggcgg tggccccggc
    14581 ggacagacga tcggcgaccc gccgtgggtg cgcgcggcga tgcggcagac cggggagcgc
    14641 tacgacgtgg tgggcgtcga cccgcgtttc gtcggccgca gcacaccgct ggactgccac
    14701 tggcccaccg gctcctccat acgcggcgcg gggaccgacc gtgcgggctt cgaccgctcg
    14761 gtggccatgg ccgaggacct cgccgatcgc tgccggacgt cccagggcga ggtcctgccg
    14821 tacgtcacca cccggaacac cgcgcgcgac ctggacgtcg tccgcgccgc gctcggcgag
    14881 cggaggatct cctacctcgg atactcctac ggcacctacc tcggccaggt gtacgccacg
    14941 atgttccccg gccgcaccga ccgcgtcgtg ctcgacggcg tcctcgcccc cgaccgctac
    15001 accccccggc tgctgcgcgg cacggaaccg gccaaccggc acgcgctcaa gggctgggcc
    15061 gcgtgggccg ccgcgcgcga cgccgcctac ggcctgggcc gcacgccgga ccgggtgctc
    15121 gcgaccgtgg accgcgtcca ggcggcggcc gcgcgtacgc ccctgtcgat cggcggccac
    15181 cgggtggacg accggatggt tcccgtcctc ctcctcaacg gcctctccca ggacaacgac
    15241 gcggcctacg gcgacttcgc cctggccgta cgggacatgc gccgcgccgc cgacggccgt
    15301 acggtcgcgc cctcgccgtg gctggccgaa acgctcggtt tcctgatgag cggatccgac
    15361 tccgcgtacg gcagcgtcca gacggcgatc ctgtgcgggg acgtgtccgc gccgcgctcc
    15421 cccgaggtgt actggcgcga cgtccaacgc tcccgcgcga aggacccgtt gttcggtccc
    15481 gtcagcaaca acatcacccc ctgcgccttc tgggacccgc cgcgcgaacg cccgaccgca
    15541 atccgcggcg acctcccggc cctgctcgtc aacgcgaccg gtgatccgcg caccacctac
    15601 gacagcgcgc ggtcgctgcg ccgcatgtgg ccgtcctccc gactggtcac cctccgcggc
    15661 gcggaccagc acgccgtgta cggcatcttc ggcgactcct gtaccgacgc gacggtcaac
    15721 agctacctgt ccaccggccg cctgccagcc acggacgtca cctgcgaccg gtcgtccggc
    15781 tgagggaccc ggttcgacca ccgagggcac cgggggcgac gacggggccg gtcagggcgt
    15841 tccccgccgg gccgcctcgc ggagggtacg ttcggcctcc gccagtcggt cgatcggcgt
    15901 ggtgtcccgc aggcccggta cgcagaccac gtcgccggtg tccagcgcgg ccagcgacgc
    15961 gtcgacgacc tggtgcaccg gcatgccgcc gtcctcgtgc acctgctgtt cccggccctc
    16021 gaccggctcc tcgccgcgtg agcggtggaa ctcggtggcg gtcaggccgg ggcagagcac
    16081 ctggacgtgc aggggtgtgc cggccagttc ggcggcgagg gtgcgggtga aggtgaccac
    16141 gtaccccttc gtgccgccgt acaccgcgcg ttcgggcagc ggtcccggtg gcagagaccc
    16201 ggcgaaggcc agttgcgagg ccacgttgac cagggtgccg cggccgcgct cccgcatcgc
    16261 ggcgaccgcc gaccgggcca gcacggtgac cgcgaggacg ttgacgtcca gcactttccg
    16321 caggagcgcg gggtcgaggt cggtgaacgg gccgtagccg ttgatccccg cgttgttgag
    16381 gaggaagccg atgtcgtcgc cggcggcccg gtccgccacg cgcgccaggt ccgcggggtc
    16441 cgagaggtcc gccaccaggg tctccaccct ggtgcccgtc ccctcctccc gcagccgccg
    16501 cgcgaggtcg tcgagccgct gggcccgcct cgccaccagg acggtgtccc atccccgcgc
    16561 ggcgaggcgc cgcgcgtacg ccgcgccgat gccggaggag gctcccgtca ccagggccgt
    16621 gcgtccctgc cgggtgctct cggcgctctc ggtgctcacg ttcgcgtcac ctctcgctct
    16681 cgctgctctc gctgcggtcg gtgccgggta ccccacccgg cgcgtcgaag gcctcgcggg
    16741 cccgggtgat ggcgggcatg tggtccgcgg cccaggtgag cagcacgtcg atgggcgggc
    16801 gcagggtctt gccgaggggc gtgatgcggt agctgaccgc caccgggcgg gtggacacga
    16861 cctcgcgtgc gaccacgccg ttgcgctcca ggcgccgcag ggtcgccgtc agcgacttct
    16921 gggtgacctg cgggatggcc cggcgcagtt cgttgaagcg gcacgggcgt tcgcacagtt
    16981 cgctgaggac gctgagcgac cacttgtcga gcacctggtc gagcagttcg cggtgcggag
    17041 ggctgatgcg gacggtgtcc atggggaaac ctggtctcgt tgaagtgtcc ttcttgtact
    17101 aagtagctta cggatacctg aaccgggcac cgagtaagca gggagtacac ccatggccgt
    17161 tcggcacttc acaccgcgag gcttgctgca accgactccg taccaccacg tggccgtcgg
    17221 gaccggtacg acgcacgtcc atgtcagcgg gcagatcgcg cgcctggccg acgggacgcc
    17281 ggtcgcgccg ggcgacctgg ccgggcaggt ctcccaggcg ctgcgcaaca cctcggtcgg
    17341 gctggcgggt gcgggcgcgt cgttcgcgga cgtgctgcgg ctgaccttct acgtgaccgg
    17401 gtggcgcccg gagaagatcg acgccttcat ggccggggtg gaggccgtcg ccgacgagat
    17461 cggcctcccg cgccccatgc cgccggcctc cctgatcggc gtggaccatc tcttcgagcc
    17521 ggacgtcctg gtggaggtcg aggccaccgc actggtcggt tgacccgcga caccacccgc
    17581 ctccgctgcg acaggcccag gtcggtgacc tgggcctgtc gcagcggagg cgggtgccgc
    17641 ccggggctcg tcatccgcgt cgcgcgaggc ggcggtgttc gaggagcgcg gcgagggcgt
    17701 acgcgccgcc gccggccagg gtgaggaccc agtagaaggc ggggtcgccg aggaggaggg
    17761 cggccgtgga ggtgagggcg agccaggtgc cgagggcgta gtggagcgtg ttgcggcggg
    17821 tggcgccctc ggcgacgtag atgacgccga cgacgaagcc cgagccggtg ggccacagca
    17881 gcgtctggag gtcggggttg tccacggcgg cggccaggcc cgtgatgagg aggaacaggg
    17941 cggcgaaggc cgtgacccag agggcgccga ggagctggcc ggtgcggacg gcggcggggt
    18001 cggtggtggc gcgctgggcc cgcagggctg cgagggtggc gagtacggtg cccgcggcga
    18061 ggcccgctcc gaggagggcc atgggcagcc atcccggcag gtcgagcagg ggtgcgtcgc
    18121 cccgggagag ggcggccgag ccgtggccca gcacgtaggc caggccgaag ctgacgtagg
    18181 tcgcaaggtt ggcgacgtcg gccgaggggc ggggcgcgac cggcgcggtg ggggcggcga
    18241 cggcgggcac ggtgaacgac atggctgggt ctccgggggt gaggagtggc gcgggaggga
    18301 gggggagaac gggctccccg tgaagcgcgt ggggtgaatg gggtgtgtgg ggtgagtgag
    18361 gtgtggggcg cgggcgcgtg gagtacgggg gaggcggtgc ccgggggccg gggcttcggg
    18421 gccggtgtcg ccggtctcac ttgccgggga cgatgacgac cttgccggcg acggtgcggg
    18481 actcggccag tcgcagggcg gcgacggtgt cggccagggg gaaggtcgcg gcgatctgcg
    18541 gggtgaggct gccgtcggcg accaggcgca ggacctgggt gaagtcctcg gtcatgcgcc
    18601 gctgccagga ggtctggcag cggcgcttgc cggcccagag gttgtagaag tgggcaccct
    18661 tgccgttcgg catggcgttc caggcgccga ggcgggcgaa gagcttgagc acgggtgcct
    18721 gggagttgcc ctcctcgtcc ttgctcgcgg cggtgccgta ggagacgagg gtgccgccgc
    18781 ggcgcagcag ctgccaggag tcctcgatgg cggggccgcc gatgtggtcg aagacggcgt
    18841 cgacgccgtc gggggccagt tcgcggatgc gggcgtacat gtccgggtcg cggtagtcga
    18901 ccgggctgac tccgagctgg cgcagcgctt cgtggtggcg gggggaggcg gtgccgatga
    18961 cggtgatgcc ggcgtggcgg gcgagctgga cgagggtgga gccgacgccg ccgttggcac
    19021 ccaggaccac gatggtgccg cccgcccgga ccttggcggt gcggtgcagc atctgccagg
    19081 cggtgacgcc gttgacgatc acggtctcgg ccgcggccgg gtcgatgccg tcgggtacgg
    19141 gcatcaggtc ggcggcgtcg acgacgaggt ggctggccca ggcgccggtc ttggtgacgg
    19201 cggcgaagcg gcgcccgacc agctcggggt cggccccggg gcccgtcccg acgacggtgc
    19261 cgaccaggtc gtagcccggc acgaagggga agggcggctg gtcgaagtac ttgccgcggc
    19321 gcatctgctg ctcggcgaag gagacgccgg tcgcctccat ccgcaggacg acctggccct
    19381 tggccggggc gggcagttcg tgggtgcgca cctccaggcc ctcgggctcg accttgcccg
    19441 gcaggacgac ctcggtcgcg gtgacggtgg tgggggtggc ggtgtggtgg tccatggctt
    19501 gtcctcgcga ttcggttcac ggctggctcg aaggctgcgg ctgcggcctg ggcttcgggc
    19561 gtttgcttac ggctgtaaag ctacgggcgt aggagccggt cgcacaagag gctacggcga
    19621 taagttttcg ctcgtaaggt tacgagaagt ggaagatccc gctccgcctg gtaccaccgc
    19681 gccgcccgcc cgcgtgccga gttgtccgcg aacccctccg ggactgtccg cgatccgtaa
    19741 cgggcggatc cccgggcaac cctccgccgt cctgcctgat ggactcgggc tgatcgaggc
    19801 cggcgggcaa cagcgggaag gcggggcgga catggcgcgg cacggtgcgg ggcggggctg
    19861 gtacggcaag gtggtcgggg gcgcgctcgg ggtgacgctg ctggccgtcg gggcgtcggt
    19921 gtggaccgcg caggccgatt ccgtcggcag cgcgtcaccg aagccgtccg cgtccgccgc
    19981 cccgggcgga gcggccgaac ccgtcgacgt gtccatcgtg cacgcctcgg acgcgggagc
    20041 gcgcggcgtc aacatcacca tcgacgacgg ccccgacccg acgtggaccc cccaagtgct
    20101 cgacctgctc gacgagtacg gggtgaaggc cacgttctgc gtgacgggcg ttcaggcgca
    20161 gacctatccg gacctcgtgc agcaggtcgt cgcggccggg caccggctgt gcgaccacac
    20221 cgtctcccac gacacggcca tggacaagaa gccggagtcc taccagtcga aggagatcct
    20281 cgacgccgag cgcatgatca tcaaggcgtc cggaggcgta cggcccctgt actaccgggc
    20341 gcccggcggc gccttcaccc cctacagccg caagctcgcc gcctcccacg ggatgcgccc
    20401 gctgggctgg aacgtggaca ccaaggactt cgagcggccg ggcacggacg ccatcgtcga
    20461 gaccgtgcag cgggagctct ccaacgggcc gacgctgctc ttccacgacg cgggcggcga
    20521 ccgcacccag accgtcgagg ccctgcgccg ggtcctgccc tggctcaagg agcagggtta
    20581 ctccttcggg ttcccggtgc gctgagtccc ggccctggcc ctccggcggg cggcggccgc
    20641 gtgcgtccgg gccggccggg gtcgcctatc ttggcggcca tgcaggcata cacgatcggc
    20701 caggcggccc ggctgctcgg cgtgagcccg gacacggccc ggcggtgggc ggacgcgggc
    20761 cggatggcga cccaccggga cgagggcggc aggcggctca tcgacgggaa ggacctcgcc
    20821 gccttctccg tggaactggc ccagggcggc gcgggcggcg aggagggcgt gtcctacacg
    20881 tcggtgcgca acgccttccc cggcatcgtc accgcgatca agctcggtga cgtggcggcg
    20941 caggtcgaga tccaggccgg cccgcaccgg ctggtgtcgc tgctgacccg ggaggcggtg
    21001 gaggaactgt ccctggaggt ggggatggag gccaccgccc gcgtgaagtc cac
//
