LOCUS       NZ_CP043317            10216 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces olivaceus strain SCSIO T05 chromosome, complete genome.
ACCESSION   NZ_CP043317
VERSION     NZ_CP043317.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivaceus
  ORGANISM  Streptomyces olivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated
            Production of Lobophorin CR4 via Metabolic Engineering and Genome
            Mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8458055)
  AUTHORS   Zhang,C., Ding,W., Qin,X. and Ju,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2019) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Science, NO.164 Xingang Road, Guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-MAR-2017
            Assembly Method                   :: HGAP v. MAR-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 8458055.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015244315.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:39:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,352
            CDSs (total)                      :: 7,265
            Genes (coding)                    :: 7,077
            CDSs (with protein)               :: 7,077
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 188
            CDSs (without protein)            :: 188
            Pseudo Genes (ambiguous residues) :: 0 of 188
            Pseudo Genes (frameshifted)       :: 106 of 188
            Pseudo Genes (incomplete)         :: 98 of 188
            Pseudo Genes (internal stop)      :: 7 of 188
            Pseudo Genes (multiple problems)  :: 23 of 188
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:52:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 504307
            Orig. end                         :: 514523
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP043317.1.
            Bacteria and source DNA available from South China Sea Institute of
            Oceanology, Chinese Academy of Science; 164 West Xingang Road,
            Guangzhou 510301, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    116..131
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.64"
                     /tool="antismash"
     misc_feature    complement(119..134)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            complement(246..2693)
                     /db_xref="GeneID:69758834"
                     /locus_tag="FYC74_RS02085"
     CDS             complement(246..2693)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69758834"
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068579.1"
                     /locus_tag="FYC74_RS02085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_194274476.1"
                     /transl_table=11
                     /translation="MGGEGAAERGSRTLRAEGALKAIAAGPDRQERTRRVLEQALVFAG
                     ASCAALYTPGDHRDLLCLVESAGVPRTLYGVRDSYPASGGSPVADAHRGGAAVWVGPEE
                     FAGSAESRRVPSSGLSLAALPVRGDGGGCLLALTGHPDGFGAEDRACLELIAEALTCPV
                     PTEAAEGGELRPTAFTLAMDSGRVEAGDGVLRLFGLAPGEFDGRVETLLGLTVPEDLPS
                     LMSVTEADHMTIGDRELEFRVLQPTGPPKWLRLSGRLLPGGEGRPTRLLGTVADASTLR
                     PDVTDVARVQRLAAALATAGTVRDVSQAVVAALRRPLRADRIALAELENERLVVTVLDP
                     PDPESWPELWRLEWRTEWPDAPVRAMPTLAAALREGRARIWPAGTGDLEPALADVGPGG
                     LAVLPLPAGGRMAGACLIGWDAPHDFGPDERALLTASAGLAGQALMRAHAFDAEHELVG
                     MLQRQLLPRRLPELPGAVAVARYLPSTAGLELGGDWYDVIPLPDHHVALVIGDVQGHSA
                     GAATLMGQMRTALRAYAAEGHPPDVVVSHANRLLVDMETDLFATCVYVDLDMEAGAAWC
                     VRAGHLPPVLRHPDGSTEIAEAEGGPPLGVVPQADFPMSPLRLRPGTLIALTTDGLVET
                     PESDIDAGLDRFAHALAGSDPAHLGLLADALLGEARRSDDVALLLVRYDGMDLRPLRES
                     WSVWRLPEAVRHARRFARRTLRSWDVPDDTTDGVLLIVSELVTNALVHTDGQVRLDLAL
                     IGGRLRVAVADASPRTPAKPTSIGWEATGGRGILLVEAMSAAWGTLPVGGGKQVWSEIA
                     LEE"
     misc_feature    complement(2773..2787)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.6"
                     /tool="antismash"
     gene            complement(3024..4394)
                     /db_xref="GeneID:69758835"
                     /locus_tag="FYC74_RS02090"
     CDS             complement(3024..4394)
                     /codon_start=1
                     /db_xref="GeneID:69758835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978109.1"
                     /locus_tag="FYC74_RS02090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S1 family peptidase"
                     /protein_id="WP_194274477.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAAMAAGGVVALGAAAILLPNANASQDGGGSHDAAA
                     APRTLKAADASDLASQLAGQLGDAFAGSYYDAGAQRLVVNVVPGDDDQVAVRAQRAGAE
                     IREVDNSMTELHGGAQTLKSEATIPGTSWAIDPRTNKILVTADSTVTGEKWDRLESTVG
                     RLGSNMATLEKSAGTFKTFVSGGDAIFGGGARCSLGFNVTAGDGSPAFLTAGHCGVAAD
                     AWSDAQDGQPVGTVDQAVFPGEGDFALVTYDDPATEAPSEVNLGDQTLQISGAAEATVG
                     EQVFRMGSTTGLADGQVLGLDATVNYPEGTVSGLIQTDVCAEPGDSGGSLFTQDGLAIG
                     LTSGGSGDCTAGGETFFQPVTTALEAVGATLGDDADDGAGEQPGGEEAGGAGAGGDEAG
                     GDGAGGGDAVGGGDEAGGEQPGGDDAGDSTGAGGSVSGSGSDDGTGTGAGDGSGPLG"
     gene            5001..5216
                     /db_xref="GeneID:69758836"
                     /locus_tag="FYC74_RS02095"
     CDS             5001..5216
                     /codon_start=1
                     /db_xref="GeneID:69758836"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="FYC74_RS02095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type A2 lantipeptide"
                     /protein_id="WP_194274478.1"
                     /sec_met_domain="strepbact (E-value: 1.3e-36, bitscore:
                     123.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSIPQVETAEISDADLDNVSGGLNVNAVGTVTGLVDGVAPVSGL
                     VNTAVGTVEGVTGLNTAPVTGLVAGL"
     gene            5396..6202
                     /db_xref="GeneID:69758837"
                     /locus_tag="FYC74_RS02100"
     CDS             5396..6202
                     /codon_start=1
                     /db_xref="GeneID:69758837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="FYC74_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_194274479.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPDELDLPVRLARPQGWLVLSVTVAAMAAASVW
                     AVGGSVTSTVSAPAILTHGQGSYLLQSPVSGQVTAVLARPGQRLGADAPVLKVRTADGE
                     SVVRTVDAGRVSALAATVGQIIQTGANVASVEKVAHTGDPLYATVYVPADNAAAVPANA
                     SVDLTVQSVPTQQYGVLHGKVKSVDRSAQSAQTIGAFLGDSQLGEQFTKDGRPVAVTVR
                     LTASESTKSGYAWSSADGPPFELTSMTLASGSIRLADQRPVDWLLP"
     gene            6199..8421
                     /db_xref="GeneID:69758838"
                     /locus_tag="FYC74_RS02105"
     CDS             6199..8421
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:69758838"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="FYC74_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_194274480.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.1e-39, bitscore:
                     133.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAQETRGRRRAAPPRRSVPKSGAKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARSYGFTAKGMQMDLAALAEVAT
                     PAILFWEFNHYVVYDGMGRRFGRRGVFINDPGKGRRFVSLEDFDGSFTGVVLTMEPGAD
                     FTRGGRRPGVLGAMPARLRGTAGTLPAAVLASLLLVAVGAAVPALSRTYIDMFLIGGQT
                     SLLGVLFASMAACVLLTVLLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTFVGIGVALLNIL
                     AMRVVVRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSGLILWIGGMRAVEGHISVGLLVAFQSLVVRFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFRTDPLYDRPGGPDSTRRLQGHVELQNVSFGYNP
                     LDTPLLTGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWDGVIRIDGQRLEDVPR
                     GALAASVSFVDQDVFLFEGSVRDNVALWDPSIPDTAVVDALKDAALYDVVMRRPGGIGS
                     PVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETELVVMDNLRRRGCACV
                     VIAHRLSTVRDSDEIVVLEHGSVVERGRHEQLVAHGGAYAALVRER"
ORIGIN
        1 cgtcctcgac ggcgggtacg caggtgcgca tcaggccact cccccgcagc cggcgggcct
       61 tcgaccatcc ggtctccacc cgacggacag cggctttgcc gctggtgtcc gtggtcacga
      121 gcatcatctt ccttctgctt ctggcgcgtc gctaccgcgt ccggtgcact cgcccgggcg
      181 ggtccccgga ccgggctccg tgaaacaccg ggcacggcgg cccacgggcc ggaccgggac
      241 gccgttcact cctccagcgc gatctcgctc cagacctgct tgcccccgcc gaccggcagc
      301 gtcccccacg ccgccgacat cgcctcgacg aggaggatgc cgcgcccgcc ggtggcctcc
      361 cagccgatgc tggtcggttt ggccggtgta cggggcgagg cgtcggcgac cgccacgcgc
      421 agccggccgc cgatcagggc gaggtcgagg cggacctggc cgtcggtgtg cacgagggcg
      481 ttggtgacga gttcggagac gatcaggagg acgccgtcgg tggtgtcgtc cgggacgtcc
      541 caggagcgca gggtgcgccg ggcgaagcgg cgggcgtgcc gcacggcctc cggcagccgc
      601 cacaccgacc agctctcccg cagcgggcgc aggtccatgc cgtcgtagcg caccaggagc
      661 agggcgacgt cgtcactgcg gcgggcctcg ccgagcaggg cgtcggcgag gagccccagg
      721 tgggcggggt cggagccggc cagcgcgtgg gcgaaccggt cgaggcccgc gtcgatgtcg
      781 ctctccggcg tctccaccag gccgtccgtg gtgagggcga tcagggtgcc gggccgcagc
      841 cgcagcggac tcatcgggaa gtcggcctgc ggcaccacgc cgagcggcgg cccgccctcc
      901 gcctcggcga tctccgtgct gccgtcggga tggcgcagca ccggcggcag gtgcccggcc
      961 cgcacgcacc aggcggcccc cgcctccatg tcgaggtcga cgtagacgca ggtggcgaag
     1021 aggtcggtct ccatgtcgac cagcagccgg ttggcgtgcg agaccaccac gtccggcggg
     1081 tgcccctcgg ccgcgtaggc gcgcagggcg gtgcgcatct ggcccatcag cgtggcggcg
     1141 ccggcgctgt ggccctggac gtcgccgatg acgagggcca cgtggtggtc gggcagcggg
     1201 atcacgtcgt accagtcgcc gcccagttcg agtccggccg tgctgggcag gtagcgggcg
     1261 acggcgaccg cgccgggcag ctccggcagg cggcgcggca gcagctggcg ctggagcatg
     1321 ccgaccagtt cgtgttcggc gtcgaaggcg tgggcccgca tcagggcctg tccggcgagg
     1381 ccggcggagg cggtgagcag ggcgcgttcg tcggggccga agtcgtgcgg ggcgtcccag
     1441 ccgatcaggc aggcgccggc catacgtccg ccggcgggca gcggcagcac ggcgagccca
     1501 ccggggccca cgtcggcgag cgcgggctcc aggtcgccgg tgccggcggg ccagatccgg
     1561 gcgcggccct cgcgcagggc ggcggcgagg gtgggcatgg cccgtaccgg cgcgtccggc
     1621 cactcggtgc gccactccag ccgccacagc tcgggccagg actcggggtc gggcgggtcg
     1681 aggaccgtga ccacgagccg ttcgttctcc agctcggcca gcgcgatccg gtcggcgcgc
     1741 agcggcctgc gcagggcggc gaccacggcc tggctgacgt cgcggacggt cccggcggtc
     1801 gcgagggcgg cggcgagccg ctggacgcgg gcgacgtccg tgacgtccgg gcgcagcgtg
     1861 gaggcgtcgg cgacggttcc gagcaggcgg gtcggccggc cctcgccgcc gggcagcagg
     1921 cgcccgctga gccggagcca cttcggcggc ccggtgggct gcagtacgcg gaactccagt
     1981 tcgcggtcgc cgatggtcat gtggtcggcc tcggtcaccg acatcagtga gggcaggtcc
     2041 tccggcacgg tgaggccgag cagcgtctcg acccggccgt cgaactcacc gggggcgagg
     2101 ccgaacagcc gcaggacgcc gtcgccggcc tcgacccggc cgctgtccat cgcgagggtg
     2161 aaggcagtgg gccgcagttc cccgccctcg gcggcctcgg tggggacggg gcaggtcagg
     2221 gcctcggcga tcagttccag gcaggcgcgg tcctcggcgc cgaagccgtc cggatgcccg
     2281 gtcagggcga gcaggcagcc gccgccgtcc ccgcgtaccg gcagcgcggc gagcgagagg
     2341 ccgctggacg gcacgcgccg cgactccgcc gaaccggcga attcctccgg accgacccac
     2401 accgcggcgc cgccccggtg ggcgtcggcg accggggagc cgccggatgc cggatagctg
     2461 tcacgcacgc cgtacagggt gcgcggcaca ccggccgact cgaccaggca gagcaggtcg
     2521 cggtggtcgc cgggcgtgta gagggcggcg caggaggcac ccgcgaagac cagtgcctgc
     2581 tccaggaccc ggcgcgtgcg ctcctggcgg tccggtccgg cggcgatcgc cttcagggcg
     2641 ccctcggccc gcagggtcct cgaccctcgt tccgcagcac cctctccgcc cacttcgcca
     2701 ttacagcgcc aaagcgacgc ccgcgcagcc cctgcggagc tgttaccggt ggtgcggggc
     2761 gtgtgtacgt gcgtgggagc gcgcccgcgc ccggccggga cggcacccga gcgggccgga
     2821 cccggaggat gcgtgggagg ccccccgcgc tgggcggccc cgggcgcgat cacctccgca
     2881 cgaggccgat ggtgcgcgtg gggagggacg gggacgtgca ccgcggcggc ccagtgctcc
     2941 cgacggacac cgcggcggtc cggtcctccc gccggaggac cggaccgccg tcgaagtgcc
     3001 ggtcgatccc gttggcgccc cggtcagccg agcgggccgg agccgtcccc ggcgccggta
     3061 cccgttccgt cgtcggagcc ggaaccggag acggagccgc ccgcgccggt gctgtcgccc
     3121 gcgtcgtcgc cgccgggctg ctcgccgccg gcctcgtcgc caccgccgac ggcgtcaccg
     3181 cccccggctc cgtcgccgcc ggcctcgtca ccgccggcgc cggcccctcc ggcctcctcg
     3241 cctccgggct gctccccggc gccgtcgtcc gcgtcgtcgc cgagggtggc gccgaccgcc
     3301 tccagggcgg tggtgaccgg ctggaagaac gtctcgccgc cggctgtgca gtcgccgctg
     3361 ccgccggacg tcagcccgat cgcgagcccg tcctgcgtga acagggagcc gccgctgtcg
     3421 ccgggctcgg cgcagacgtc ggtctgtatg aggccgctga ccgtgccctc cgggtagttg
     3481 acggtggcgt ccaggccgag gacctggccg tcggccaacc cggtcgtact gcccatgcgg
     3541 aagacctgct cgccgacggt cgcctccgcg gccccggaga tctgcagggt ctggtcgccg
     3601 aggttgacct cgctgggggc ctcggtcgcc gggtcgtcgt acgtgacgag cgcgaagtcg
     3661 ccctcgccgg ggaagaccgc ctggtcgacg gtgccgaccg gctgcccgtc ctgggcgtcg
     3721 gaccacgcgt cggccgcgac gccgcagtgc ccggccgtca ggaaggccgg ggaaccgtcc
     3781 cccgcggtga cgttgaagcc gagcgagcag cgcgcgccgc cgccgaagat ggcgtcgccg
     3841 cccgacacga aggtcttgaa ggtgccggcg gacttctcca gcgtcgccat gttggagccg
     3901 aggcgcccga ccgtggactc cagccggtcc cacttctcgc cggtgacggt gctgtcggcg
     3961 gtcaccagga tcttgttggt gcgcgggtcg atcgcccacg aggtgccggg gatggtcgcc
     4021 tcggacttca gtgtctgcgc gccgccgtgc agctcggtca tgctgttgtc gacctcgcgg
     4081 atctccgcgc ccgcccgctg ggcccgcacc gcgacctggt cgtcgtcacc ggggacgacg
     4141 ttcacgacga gccgctgcgc accggcgtcg tagtacgagc cggcgaaggc gtcgccgagc
     4201 tggccggcga gctgcgaggc gaggtccgag gcgtccgccg ccttgagggt ccgcggggcc
     4261 gccgcggcgt cgtgtgaacc gccgccgtcc tgcgaggcgt tggcgttcgg caggaggatg
     4321 gcggccgcgc cgagcgccac cacaccgccc gcggccatcg cggccttgcg cttcggaatt
     4381 cgcttgtgac tcaacctact cgacctcctg gggccggtgg accgtgccac cggcccggct
     4441 gctgttgggg gcgccttgac ggctgttggt acgcacggac cgcgtggtgc gttcagaccg
     4501 accctccccc gcacccgggg ccgcacccgc acacccccac cactcgccac tccccgtggc
     4561 cggccggcga cccggcgtgc cgatcctggg gcggaatcgg cgcttccgtg aatctgcaca
     4621 tcgaatgccc aacccggtca tcctcgttgg cggatctgca caacccgccg ccgggcggta
     4681 cgtctttggg gcgggagtgc cccaatcggc cggggcccgg caaggggggc gtccgggccg
     4741 atgtcgcgca cggtgtgaag aagtcgcccc gaaggcgtgc ccggccctgc accgttgggt
     4801 gcgtcggcgt tgcaagtccc ctggtgggag ggggtggttg attggaagcc cggacggcac
     4861 gcgtgctttg atccatcgca ccgcggaggc cggggacgct ccggaaacgg gcgcccggtg
     4921 tccgcggtcg cggccgtcat ctgtccccag agggggccgc tccccccttg tgaaatggct
     4981 atacgaaggg aagttcccac atgaactcca tcccccaggt tgagaccgcc gagatctccg
     5041 acgccgacct cgacaacgtc tccggcggcc tgaacgtgaa cgccgtcggc accgtcaccg
     5101 gcctggtgga cggcgtcgcc ccggtctccg gcctggtcaa caccgccgtc ggcaccgtcg
     5161 agggtgtcac cggtctgaac accgccccgg tcacgggcct ggtcgccggt ctctgatcgc
     5221 gcccttgtgc cgctgagtcc cggagccgcc caggctccgg gactcttcgg ccgttccacc
     5281 cgacgccttc cttccgccaa cccactcgtc ccacccggtc ctctcgtgct cacgaggctc
     5341 ttcgggagca cggcgaatca cggggaatca cgggaatcac tggggtacgt ccgccgtgca
     5401 gttccgccaa caggccctct ccaagctcca gtcgccggat gagctcgatc ttccggtgcg
     5461 tctcgcccgt ccgcagggct ggctggtgct gtccgtgacc gtggccgcga tggccgccgc
     5521 gtccgtgtgg gcggtgggcg gctcggtgac ctccaccgtc tccgcgcccg ccattctcac
     5581 gcacggccag ggcagttacc tcctgcagag ccccgtctcc gggcaggtca ccgcggtcct
     5641 cgccaggccg ggtcagcggc tgggcgccga cgcccccgta ctgaaggtcc gcaccgccga
     5701 cggcgagagc gtggtccgca cggtcgacgc cggccgggtc agcgcgctcg ccgccaccgt
     5761 cggccagatc atccagaccg gcgcgaacgt cgcctcggtc gagaaggtcg cccacaccgg
     5821 cgacccgctg tacgccaccg tctacgtgcc ggcggacaac gccgccgccg tacccgcgaa
     5881 cgcctccgtc gacctgaccg tgcagtcggt gccgacccag cagtacgggg tcctgcacgg
     5941 gaaggtgaag tcggtggacc gctcggcgca gtcggcgcag acgatcggcg cgttcctcgg
     6001 ggacagccag ctcggcgagc agttcaccaa ggacggcagg ccggtggccg tgacggtgcg
     6061 gctgacggcc tcggagtcga cgaagagcgg ctacgcgtgg tcgtcggcgg acgggccgcc
     6121 gttcgaactg acctccatga ccctggcctc gggctcgatc cgcctggccg accagcgtcc
     6181 cgtcgattgg ctgctgccgt gagtaccgcc caggagaccc gcggcagacg ccgcgccgcc
     6241 ccgccccggc gcagcgtgcc gaagagcggc gcgaagaccg tccgcacccc caccgtgctc
     6301 cagatggagg ccgtcgagtg cggcgccgcc tccctcgcga tggtgctcgg ccactacggc
     6361 cggcacgttc cgctggagga gctgcggatc gcctgcggcg tctcccgcga cggctcccgg
     6421 gcgagcaacc tcctgaaggc cgcccgcagt tacgggttca ccgccaaggg catgcagatg
     6481 gacctggccg cgctcgccga ggtggcgacg ccggccatcc tgttctggga gttcaaccac
     6541 tacgtcgtct acgacggcat gggccgccgg ttcgggcggc gcggggtgtt catcaacgac
     6601 ccgggcaagg gccggcgttt cgtgtccctg gaggacttcg acggcagctt caccggcgtc
     6661 gtcctgacca tggagccggg cgcggacttc acccggggcg gccgcaggcc cggcgtgctc
     6721 ggcgcgatgc cggcccggct gcggggcacc gccgggacgc tgccagccgc cgtgctggcc
     6781 agcctgctcc tggtggcggt cggcgcggcg gtgcccgcgc tcagccgcac ctacatcgac
     6841 atgttcctga tcggcgggca gacctcgctg ctcggtgtgc tgttcgcctc gatggcggcc
     6901 tgcgtgctgc tcacggtcct gctcacctgg ctccagcaag ccaacctgct gcacggccgc
     6961 atcatctcct ccaccctctc cagcgcccgc ttcctgcgtc atctgctgcg gctgccggtg
     7021 acgttcttct cgcagcgcag cccggccgac ctggtgcagc gcctgcagtc caacgacgcc
     7081 gtcgccgaga cgctggcccg cgacctcgcg gcggcgggcg tggacgcgat cgtggtcgtc
     7141 ctgtacgcgg tgctgctgta cacgtacgac ccgcagctga ccttcgtcgg gatcggcgtg
     7201 gcgctgctca acatcctcgc gatgcgggtc gtcgtgcggc tgcgggcgac ccgtacggcg
     7261 aagctgcggg ccgacacggc gcggctgacg aacaccgcgt acaccggcct gcagctgatc
     7321 gagacgatga aggcgacggg cggcgaggac ggctacttcc gcaagtgggc ggggcagcac
     7381 gccaccacgc tggaggagca gcagcggctg ggggtgccga gtgcctggct cggggtggtc
     7441 gcgccgaccc tggcgacgct gaacagcggg ctgatcctgt ggatcggcgg catgcgcgcg
     7501 gtcgaggggc acatctcggt cgggctgctg gtcgccttcc agtcgctggt ggtccgtttc
     7561 acggccccgc tgacccgcct gaacggcgtg gcgggccgca tccaggactt cgcggcggac
     7621 gtggcgcggc tgaaggacgt ggagaacttc cgcacggacc cgctctacga ccgccccggc
     7681 ggcccggact ccacccgccg gctgcagggg cacgtcgagc tgcagaacgt ctccttcggc
     7741 tacaacccgc tcgacacacc gctgctgacc ggcttcgacc tgaccgtggg ccccgggcag
     7801 caggtggcgc tggtgggcgg ctcgggcagc ggcaagtcca cggtgtcccg gctgatctcg
     7861 ggcctgtacg ccccgtggga cggggtcatc cgcatcgacg ggcagcggct ggaggacgtg
     7921 ccgcgcgggg cgctggccgc ctcggtctcc ttcgtcgacc aggacgtgtt cctgttcgag
     7981 ggctcggtgc gcgacaacgt ggcgctgtgg gacccgtcga tcccggacac cgcggtggtg
     8041 gacgcgctca aggacgcggc actgtacgac gtcgtgatgc ggcgtcccgg cggcatcggc
     8101 agcccggtcg agcaggacgg ccgcaacttc tccggcgggc agcgccagcg cctggagatc
     8161 gcgcgggccc tggtgcgccg tcccagcatc ctggtcctgg acgaggtgac cagcgcgctg
     8221 gacgcggaga cggagctggt ggtcatggac aacctgcgcc ggcgcggctg cgcctgcgtg
     8281 gtgatcgcgc accggctgag caccgtgcgg gacagcgacg agatcgtcgt cctggagcac
     8341 ggcagcgtcg tggagcgcgg acggcacgag cagctggtgg cgcacggcgg tgcgtacgcg
     8401 gcgctggtca gggagcggtg agatgacggc cgtgcacgac ggacagggcg acctcgtcct
     8461 cggggcgctc ggcgcgctgg gcacgcgggt ggactgcgcc gggctcaacc gcctcgacct
     8521 ggaggggccg caggtgctgt ggctggtggc gtccggcgcg gtcgacctgt tcgcggtcga
     8581 cgccggggag cagggccact ggcaccacct ggggcggctg gaggcgggct cggcgctgct
     8641 cggtccggtg gcgggcccgc agcacaccct ggtcgcgcgt ccgctgcggg agtgcgtggt
     8701 gcaccgcatc gggctgcgcg agctgtacca gccggcgccc acgcagacgt ggtcgtacga
     8761 cgagtacggc aacccgcagt acgtgccgcc gacgacgagc ccgctggagt acgccctggc
     8821 gctcggcgtg ggccgcggcc tgacggtcct gttccaggcg ccgatggccg cggaacgggc
     8881 cgccgcgccc accgacgacg acgtgttctg gatgcaggtg ccgccgggca gcgtgcagta
     8941 cggggcggtg tacggcgagg aggccgccgc cgacctgctg atggacccgg cgctgtggca
     9001 gagcctggtc gaccagcagt accggctgct gacgacgctg gaccgctgga tcgagcagtt
     9061 ggagcgcacc cacgagacgc ggacggcggc cggaatcaag gcgggtgagg ccgtgcgcgc
     9121 gcaggccgac cgaaccctgc tggcctccat cgggaagcgg tcggcggggc gcgccacggc
     9181 cgccgacgcc gacgcctcgt acgcggcgtg ccggctggtc gcccgcgccg ccgggatccc
     9241 gctcgccgag cccgcgcggg gcggcacgga gagcgagcgg ctcgatccgg tcgagcgggt
     9301 cgccctcgcc tcgcggctgc ggacccgcac ggtgcggctg gaggacggct ggtggcggga
     9361 cgacgtgggg ccgctggtcg ggcaccggag tctgtcgggg gcgccggtgg cgctgctgtg
     9421 gcggcgcggc ggctatgcgg ccgtgcatcc ggcgaccggc cgggagactc cggtggagcg
     9481 ggacaacgcc gaggagttcg agccgagcgc ggtgatgttc taccggccgc tgccggaggg
     9541 ccggctcggt ccgctcgggc tgctgcggtt ctgcctggcg ggcacccgcc gggatctgac
     9601 cgggctgctg ctgagcggcc tggtgacggt ggggctcggc gcgctggtgc cgatcgcgac
     9661 gggccgggtg ctcggggagt tcgtgccgac ggcgcagacc gggctgatcg tgcaggtgtg
     9721 tctcgcggtg atgctgagcg gtgtcgtcgc ggcggccttc atgctgttgc agaacctcac
     9781 catcctgcgg ctggagggcc gggtcgaggc gacgctgcaa ccggccgtgt gggaccggct
     9841 gctgaggctg ccgacgaagt tcttcacgga gcgctcgacc ggcgagctgg cgagcgcggc
     9901 gatgggcatc agcgcgatcc gcaggctgct ggcgggcgtc ggcccgacgg tggcccagtc
     9961 ggtgaccgtc ggggcgatga acctggggct gctgctctgg ttcagtgtgc cgatggcgct
    10021 ggcggcgatc ggcatgctgg tggtcgtggc cggggtcttc ctgggcctcg ggctgtggca
    10081 ggtgcgctgg cagcggcggc tggtcaagct caccaacaag ctgaacaacc aggcgttcca
    10141 gacactgcgc ggcctcccga agctgcgggt ggcggcggcg gagaactacg cctacgcggc
    10201 gtgggcggaa cggttc
//
