LOCUS       NZ_JADEWH010000024     28657 bp    DNA     linear   CON 23-DEC-2023
DEFINITION  Nodularia sp. LEGE 06071 N071000024, whole genome shotgun sequence.
ACCESSION   NZ_JADEWH010000024
VERSION     NZ_JADEWH010000024.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nodularia sp. LEGE 06071
  ORGANISM  Nodularia sp. LEGE 06071
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Aphanizomenonaceae; Nodularia.
REFERENCE   1  (bases 1 to 50094)
  AUTHORS   Castelo-Branco,R., Eusebio,N., Adriana,R., Vieira,A., Brugerolle De
            Fraissinette,N., Rezende De Castro,R., Schneider,M.P.,
            Vasconcelos,V. and Leao,P.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-2020) Cyanobacterial Natural Products, CIIMAR,
            Terminal de Cruzeiros do Porto de Leixoes, Matosinhos 4450-208,
            Portugal
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: SPAdes v. nov/18
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 30x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/23/2023 19:29:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,867
            CDSs (total)                      :: 4,805
            Genes (coding)                    :: 4,703
            CDSs (with protein)               :: 4,703
            Genes (RNA)                       :: 62
            rRNAs                             :: 6, 7, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 3, 3 (5S, 16S, 23S)
            partial rRNAs                     :: 4 (16S)
            tRNAs                             :: 42
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 102
            CDSs (without protein)            :: 102
            Pseudo Genes (ambiguous residues) :: 0 of 102
            Pseudo Genes (frameshifted)       :: 22 of 102
            Pseudo Genes (incomplete)         :: 84 of 102
            Pseudo Genes (internal stop)      :: 12 of 102
            Pseudo Genes (multiple problems)  :: 15 of 102
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:23:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 21437
            Orig. end                         :: 50094
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADEWH010000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28657
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-v"
                     /region_number="1"
                     /rules="(APH and HopA1)"
                     /tool="antismash"
     cand_cluster    1..28657
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APH and HopA1)"
                     /kind="single"
                     /product="lanthipeptide-class-v"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28657
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[20000:22362](-)"
                     /cutoff="20000"
                     /detection_rule="(APH and HopA1)"
                     /neighbourhood="20000"
                     /product="lanthipeptide-class-v"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..22362)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APH and HopA1)"
                     /neighbourhood="20000"
                     /product="lanthipeptide-class-v"
                     /protocluster_number="1"
     gene            complement(1165..1542)
                     /locus_tag="IQ233_RS23145"
                     /old_locus_tag="IQ233_23145"
     CDS             complement(1165..1542)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015138179.1"
                     /locus_tag="IQ233_RS23145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23145"
                     /product="hypothetical protein"
                     /protein_id="WP_194003583.1"
                     /transl_table=11
                     /translation="MTGLTPFSIEKSDNFQRSFKKLAKFHGSSFVELMVEIIENLTEEQ
                     YPYNSRQEPLPSKMQLTEGWTFHKLELRFAKGASGQIRLMYLVNVTTFTIRLVWIYSHE
                     QFAKRPGEKDLKSVIEEILDC"
     gene            complement(1514..2101)
                     /locus_tag="IQ233_RS23150"
                     /old_locus_tag="IQ233_23150"
     CDS             complement(1514..2101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017308995.1"
                     /locus_tag="IQ233_RS23150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23150"
                     /product="type II toxin-antitoxin system antitoxin SocA
                     domain-containing protein"
                     /protein_id="WP_194003585.1"
                     /transl_table=11
                     /translation="MINCLDAARYFIARAYEDGIEAEMTNMKVQKLLYYSQSLYLAIYD
                     QPLFDEDIQAWRYGPVCPPAYRFYSEFEAQQLPIPSQKLLLQIPQDEKKLLEEIWGYFG
                     GYRAYRLSNMTHLEFPWTKARKGLPANASSTERILLEDMKALGYQKLDLIERDHPAFQS
                     VMSQVLEDACNSESSNRINKGEVRDWLNSLLD"
     gene            complement(2234..2938)
                     /locus_tag="IQ233_RS23155"
                     /old_locus_tag="IQ233_23155"
     CDS             complement(2234..2938)
                     /EC_number="2.1.1.130"
                     /GO_function="GO:0030788 - precorrin-2
                     C20-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011319616.1"
                     /locus_tag="IQ233_RS23155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23155"
                     /product="precorrin-2 C(20)-methyltransferase"
                     /protein_id="WP_194003587.1"
                     /sec_met_domain="TP_methylase (E-value: 5.9e-48, bitscore:
                     155.1, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTKGRLYGIGVGPGDPELLTLKALRLLQAAPVVAYQSAVDKESI
                     ARAIVSQYLTGDQIEVLFHLPRALEPETANLIYDKEVEPIAEHLAAGRDVVVLCEGDPF
                     FYGSFMYVFTRLSQHYQTEVVPGISSLMACPVALGVPFTYYNDIMTVLPAPMPAEELIT
                     HLLATDAAAIMKLGRHFTKVRDVLHQLGLASRALYIERATTTQQRIVPLDEVDPDQVPY
                     FSMIIIPTKNRL"
     gene            complement(2941..3567)
                     /locus_tag="IQ233_RS24485"
     CDS             complement(2941..3567)
                     /EC_number="5.4.99.61"
                     /GO_function="GO:0016993 - precorrin-8X methylmutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015217092.1"
                     /locus_tag="IQ233_RS24485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_227789090.1"
                     /transl_table=11
                     /translation="MSDYIRDANEIYSKSFAIIRSEAKLDVLPPDVAKVAVRLIHACGM
                     TDIVTDLGYSSTAVQAGRAALAAGAPILCDCRMVAEGITRKRLPTNNQVICTLYDVEVP
                     ALAKRLGNTRSAAAVELWRLHLEGAVVAVGNAPTALFRLLEMLEEGVLKPALILGFPVG
                     FVGAAESKAALAANSKGVPFLTLHGRRGGSAIAAAAVNALAKEEE"
     gene            complement(3634..5118)
                     /gene="cobG"
                     /locus_tag="IQ233_RS23160"
                     /old_locus_tag="IQ233_23160"
     CDS             complement(3634..5118)
                     /EC_number="1.14.13.83"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0019250 - aerobic cobalamin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="cobG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017804398.1"
                     /locus_tag="IQ233_RS23160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23160"
                     /product="precorrin-3B synthase"
                     /protein_id="WP_227789089.1"
                     /transl_table=11
                     /translation="MLSGFALCPGLFYDTPAQDGILSRIRVPGGILDSKQCHAIADIAE
                     NYGGGYVDITNRANLQIRELRSGINAAVLQDLQNIGIGSRNFAVDHIRNIMTSPTAGID
                     PQELIDTRPFVQDWENYIAAHPTLSGLSAKFSVCFDGGGTVSVCDRLNDIMFAAVLIDG
                     RVYFRLHLSVGVKGKPPIDMGIVLLPESCLPVLAALAEVYLNYTDPNSRRKLRLRELLN
                     NLGCERYLQEVEQRLGFQLTSQGQFDKTSVENRSNSNYQHIGIHPQRQPGLFYIGVVLP
                     LGRLETQQIRGLADLAQRFGNGTLRLTPWQNLLLTDIPARSLTDVKSEIAVLKLDVSAS
                     NINSALVACSGNKGCAASATDTKGDALALAKYLETHVSLNHPVHIHFSGCEKSCAQHSH
                     SDITLLGVSLESENGTMGAYHIYVGDSLRGEAIGDSNQKFGRQLYQYVTVAELPVLLGQ
                     MLQVYKIQCRNPDESFGEFVNRYEIAQLHPLFSSVS"
     regulatory      complement(5167..5307)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    5345..5365
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 28.31"
                     /tool="antismash"
     gene            complement(5441..5650)
                     /locus_tag="IQ233_RS23165"
                     /old_locus_tag="IQ233_23165"
     CDS             complement(5441..5650)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017318339.1"
                     /locus_tag="IQ233_RS23165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23165"
                     /product="hypothetical protein"
                     /protein_id="WP_194003589.1"
                     /transl_table=11
                     /translation="MKIKALDVKAGDRIIAYCKNKMQVCKVKRILEPGSTNITLSVFTS
                     EHYRGCLVSCVVRFQCDTLVDLVQ"
     misc_feature    5814..5827
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.37"
                     /tool="antismash"
     gene            5892..7112
                     /gene="cbiE"
                     /locus_tag="IQ233_RS23170"
                     /old_locus_tag="IQ233_23170"
     CDS             5892..7112
                     /GO_function="GO:0046025 - precorrin-6Y
                     C5,15-methyltransferase (decarboxylating) activity
                     [Evidence IEA]"
                     /GO_process="GO:0046140 - corrin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cbiE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015130785.1"
                     /locus_tag="IQ233_RS23170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23170"
                     /product="precorrin-6y C5,15-methyltransferase
                     (decarboxylating) subunit CbiE"
                     /protein_id="WP_194003591.1"
                     /sec_met_domain="TP_methylase (E-value: 4.3e-21, bitscore:
                     67.3, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRKWLSIVGIGEDGLQGLSAIARSLIEQAEVIVGGDRHLAMLPP
                     NDQRQKIAWTSPISSSIAEIIRRRGESVCVLASGDPFCYGIGVTLTRQIPLEEITIIPA
                     PSTFSLACAKLGWSFRETETLSLCGRPASLLHSYIYPNAKLLILSEGKDTPATVADILT
                     NRGYGGSKITVLEHLGGIQERIVEGIAADWDKREIAPLNAIAVECIANAGVVPLPRLPG
                     LPDHAYHHDGQLTKSEVRAVTLAKLAPIPGELLWDVGAGCGSISIEWMRTDSRCQAIAI
                     EQNSSRLGYIANNAAALGTPHLKIISGKAPSILQNLPTPDAIFIGGGVTAAGLFDICWN
                     ALRPGGRLVANVVTVEGEQILFKWYEQVGGSLTRIAIQRAEPIGKFLGWRAMSPVTQWI
                     AIKPENF"
     gene            complement(7181..7843)
                     /locus_tag="IQ233_RS23175"
                     /old_locus_tag="IQ233_23175"
     CDS             complement(7181..7843)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024824.3"
                     /locus_tag="IQ233_RS23175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23175"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_194003593.1"
                     /transl_table=11
                     /translation="MKFTFSKPSVLAYASSILLLGFSIPLVAQIPASNAASECQTFKPP
                     YLNTVKDFIGLGHFQEDCEKDSQSAVSSFTQAITLNPQGEEAYYHRANAYYNLGNYQAA
                     VADHSEVIRQNTGRFGFSRGAYWNRARAYEKLGEKKKAISDLNQLIGDSSPNADQYFFR
                     GNMYRDLNNKASAMADYKAAEKLLQQYLNGDFGNGLQDPRYQVMLENVRNELAQINY"
     gene            complement(7975..8544)
                     /locus_tag="IQ233_RS23180"
                     /old_locus_tag="IQ233_23180"
     CDS             complement(7975..8544)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016875485.1"
                     /locus_tag="IQ233_RS23180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23180"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_194003595.1"
                     /transl_table=11
                     /translation="MVASPEIYVTPEEYLEMEEQSDIKHEYIDGYIYAMAGALDSHVTI
                     ALNLATLLRNHVRGSGCRVYIADMKARIESLNRFYYPDVMVTCDQRDQETPAYKRFSTL
                     IVEVLSDSTEAFDRGDKFADYQLLETLEEYVLINTKRQRVECFRRNGQGLWVLQSYTAE
                     EKSFRLNSIDFEATIAELYEDVVFAS"
     gene            8740..11169
                     /locus_tag="IQ233_RS23185"
                     /old_locus_tag="IQ233_23185"
     CDS             8740..11169
                     /EC_number="2.4.1.13"
                     /GO_function="GO:0016157 - sucrose synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005985 - sucrose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196058.1"
                     /locus_tag="IQ233_RS23185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23185"
                     /product="sucrose synthase"
                     /protein_id="WP_194003597.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.2e-22,
                     bitscore: 70.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHELCETVLNSEEKITLRQFILELSATDKRYFLRNEILHNFADFC
                     HQYQKPTYFYYSSSIGRLIHNTHEMILEAEGTWFVVRPRIGSQQVWRLQTDFSGFESMT
                     PQAWLDVSDRLVNRYQPHILEIDFQPFSEESTRISDPRNIGQGLAFLNRYLCNQLSNDT
                     HYWLEVIFQALYRLTYDQKPLLISDRIPSGLHLVKQIKQALKFLNQQPPEEPYANFRPH
                     LQELGLEPGWGNTAGRISETLELLEQLIDNPQPAILEAFVARVPAIFRVALVSIHGWVG
                     QQDVLGRDETLGQVIYVLEQARSLENKLQAEIKLAGLDLLGIQPHVIILTRLIPNCKGT
                     ECNLRLEKIHDTENAWILRVPFGEFNSDITNNWISKYEIWPYLETFAQDAEKELLTQFQ
                     GCPNLIVGNYSDGNLVASLISRSLKVTQCNIAHSLEKPKHLFSNLYWQNLEEIYHFSAQ
                     FTADLISMNAADFIITSSYQEIVGTPDTIGQYESYKCFTMPDLYHVINGIDLFSPKFNM
                     VPPGVSENIFFPYHQKDRRDPEFTTQVQDLLFTREHSQILGHLDNPNKRPILTVAPITS
                     VKNLAGLAECFAKNRALQERCNLIIITSKLYPNEATNSKEVEEIQKLHDIINQYELHGN
                     IRCIGMRLPSPDLGEAYRVIADSQGIYVHFARFESFGRSILEAMVSGLPTFVTKFGGAV
                     EIIEEREDTFHINPTDFKETANQILSFIDECETQPHYWQKVSDSMSQRILNKYNWQLNT
                     SQTLLLAKIFSFWNFAAPENNAAKHRYLETLFHLIFKPRAEKILEEHMQRSLVMQN"
     gene            11213..14140
                     /gene="pgmB"
                     /locus_tag="IQ233_RS23190"
                     /old_locus_tag="IQ233_23190"
     CDS             11213..14140
                     /EC_number="5.4.2.6"
                     /GO_function="GO:0008801 - beta-phosphoglucomutase activity
                     [Evidence IEA]"
                     /GO_process="GO:0046352 - disaccharide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pgmB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196059.1"
                     /locus_tag="IQ233_RS23190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23190"
                     /product="beta-phosphoglucomutase"
                     /protein_id="WP_194003599.1"
                     /sec_met_domain="HAD_2 (E-value: 1.3e-31, bitscore: 101.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKTPNNHFIYTDWILIETHFDPEQLHSRETIFTIGNGYLGTRG
                     SFEEGYIRALPATFIHGVYDDVPVVYTELANCPDWLPLVLSINGDKFRLDQGEILRYDR
                     QLDLRQGIFSRSLRWRSPSGKTVDIHFERFASLADQHVLGQRCQVTPVDFDGMIEIQAS
                     INGYPENQGFNHWEAIDQGKTEQGIWLHSRTRGSRIDIGMAARMVISGTEAALEVHTAP
                     GYPTLTATFLATSQQTVTVEKTVTVFTSRDVSQPVPAAQEKLAQLPDYITLLQANAQAW
                     NEVWHYSDIVIEGDSKAAFAVRYNLFQLLISAPKHDEKVSIPAKTLSGFGYRGHIFWDT
                     EIFILPFFTFTQPALARNLLSYRYHTLNGARRKASHYGYKGAMYAWESAVTGDEVTPRW
                     SLPSDFYGEDIRIWCRDHEIHISSDISYAVWYYWQATGDDEWMQKCGAEIILDTAVFWN
                     SRVEFNSEQDRYEIRGVIGADEYHEFVHNNTFTNRIVQWHLEKALIVNDWLHQNFPERA
                     KELEDKLQLTAEIKTQWEDIVAKLWIPYDAETGLIEQFEGFFQLEDINWNDYEPRTQSM
                     QGILGIEKTNKLQVLKQPDVLMLLYLMRELGDFPYNQKSLQANWDYYAPRTDITYGSSL
                     GPAIHAILASDLGKSAEAYERFMQAAMVDLEDIRGNAADGIHGANAGGIWQAVVFGFGG
                     IKLRDSRPLANPHLPRGWTRLKFKLHWRGKWHEFDLRPQITQEESNKGFILFAPSSPHT
                     SKIQGVIFDLDGVLTDTAEYHYQAWQKLADEEDIEFNRQANEALRGISRRASLMRIIKN
                     KKYSEAEIQEMLERKNGYYVDLIENITPKDVLPGAIALLDELRQQGIKIAIGSASKNAQ
                     VVVERLGIADHVDAIADGYSVQQPKPAPDLFLYAAEQLGVPPDQCVVIEDAAAGVEAAL
                     AAGMWAVGLGPSERVGAAHVVLPSLAGVKWAELQDKLREAVAQKY"
     gene            14230..14406
                     /locus_tag="IQ233_RS23195"
                     /old_locus_tag="IQ233_23195"
     CDS             14230..14406
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196060.1"
                     /locus_tag="IQ233_RS23195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23195"
                     /product="hypothetical protein"
                     /protein_id="WP_194003601.1"
                     /transl_table=11
                     /translation="MSKSGRTREILQSMRNIPQQVMNYISEAVSRIFSPRDDNYPATGV
                     QPFEGDPPDKKND"
     gene            complement(14438..15853)
                     /locus_tag="IQ233_RS23200"
                     /old_locus_tag="IQ233_23200"
     CDS             complement(14438..15853)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010994209.1"
                     /locus_tag="IQ233_RS23200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23200"
                     /product="isochorismate synthase MenF"
                     /protein_id="WP_194003604.1"
                     /transl_table=11
                     /translation="MTVLPCRSNFFVKNKDLYHFLLNVQENCLKHNCRQIVSISLNIDW
                     VDPLVVLDKLTQANEINFYFENQAKGEAIAAIDTVTKLEIDGKERFHQAEHFIKFCLKN
                     IINFGNNQPTFAGPHFFCYFGFFDYNSQIDYPFPSATVFLPRWQISVKNQHCILVNNII
                     IKPSTNVESILQDLQHKIAQIQSLEYAAPNLEQLPNKFSKQSVTNPQDFKRSVGSAVEK
                     IRSSHLIKIVLANALDVKSSHIFNLFKSLNNLRQIHPNCYIFSTSNGKGQNFIGASPER
                     LISIHNQELISDALAGSAPRGKTPAEDAANANRLLNSIKERHEHSLVIDFITQRLTQLG
                     LLPEVLAPRLRQLSNIQHLWTPITAKVSANVHPLKIVSQLHPTPAVAGATRDFACAEIR
                     RYESFERGLYAAPLGWIDASGNCEFIVGIRSALIDGDRARLYAGAGIVAGSDPEKEFAE
                     VQLKLQALLKALV"
     gene            16221..17123
                     /gene="menA"
                     /locus_tag="IQ233_RS23205"
                     /old_locus_tag="IQ233_23205"
     CDS             16221..17123
                     /EC_number="2.5.1.130"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042372 - phylloquinone biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="menA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010994210.1"
                     /locus_tag="IQ233_RS23205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23205"
                     /product="2-carboxy-1,4-naphthoquinone phytyltransferase"
                     /protein_id="WP_194003606.1"
                     /transl_table=11
                     /translation="MTTKQIVNPQIKLWMAAIKPPMYSVAIMPIWVGTAVAFAETNSFN
                     VVVFSTFIAAAILILAWENISNDVFDSETGIDENKHHSLVNLTGNKLLIFWLGNLCLVS
                     GLLGIIAIAIWQKDPTVIGLILLCCALGYTYQGPPFRLGYQGLGEIICFFAFGPLAIAA
                     AYYSQTASWSINSLAASVIVGIATSLVLFCSHFHQVKDDIAAGKRSPVVRLGTAKAAKL
                     LSWFTGGIYPLILLFVLLGMFPVWTLLSWLSLPYAFQLCRHVQQNHHLPEKVSNCKFIA
                     VNLHFCCCSLLGLGFMLGG"
     gene            17171..18109
                     /locus_tag="IQ233_RS23210"
                     /old_locus_tag="IQ233_23210"
     CDS             17171..18109
                     /EC_number="4.2.1.113"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012412663.1"
                     /locus_tag="IQ233_RS23210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23210"
                     /product="o-succinylbenzoate synthase"
                     /protein_id="WP_194003608.1"
                     /transl_table=11
                     /translation="MRGYQFDFRCYRRRFLQPLVTNHGLWHTREGIIVCLGNCGYGEIA
                     PISWFGSETLEQALNFCRQLPAEVTEEMIFSIPDSLPACQFGFESALGGMGSGEDKKYT
                     QFLTYSGLLPSGEAALSEWERLWKEGYRTFKWKIGVNAISQELEIFDLLTRTLPPAAKL
                     RLDANGGLSYEEAKRWLGICDDISANIEFLEQPLPVEQFSEMLELSAGFRTAIALDESV
                     ATLKQLEECWQQGWRGIFVIKPGIAGSPSRLRQFCQQHQIDAVFSSVFETEIGRQAALQ
                     LAAELSLTNRAVGFGINHFLEPAEKPEFKCP"
     gene            18100..19470
                     /locus_tag="IQ233_RS23215"
                     /old_locus_tag="IQ233_23215"
     CDS             18100..19470
                     /NRPS_PKS="Domain: AMP-binding (30-355). E-value: 1.2e-39.
                     Score: 128.0. Matches aSDomain:
                     nrpspksdomains_IQ233_RS23215_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196064.1"
                     /locus_tag="IQ233_RS23215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23215"
                     /product="2-succinylbenzoate--CoA ligase"
                     /protein_id="WP_194003610.1"
                     /sec_met_domain="AMP-binding (E-value: 4.4e-46, bitscore:
                     148.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIELPIFYLNQLAEKDFIIGDNNHQFQQIASELYLELQHKLTSG
                     NTPKIILAEREPVRFFAGFIAACAAGCPVFLCNPDWGKQEWQQVLELVQPDIIWGLEIK
                     ISPHRISNQSPYIMIPTGGSSGKIKFAIHTWETLIASVQGFTEYFQLTQVNSFCVLPLY
                     HVSGLMQFMRSFTTGGKLAIAPFKTLASSPEYQIAPADFFISLVPTQLQRLLENPQLTQ
                     WLSQFTTVLLGGAPAWEELLEKAKFHRIRLAPTYGMTETASQIATLKPDDFLNGKINSG
                     QILPHAQVKIRNQQGEILNPYQTGNITIQAQSLALGYYPQTWENQHYLQVDDIGYLDSQ
                     GYLSIIGRSSDKIITGGENIYPVEIEAAIRSTQMVTDVCIIGLPDKHWGEAVTAIYIPK
                     HPQISSLKLQAELQKKLSKFKIPKHWISVPTLPRNPQGKINRQELQKIAAEHLQNLS"
     aSDomain        18190..19164
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IQ233_RS23215_AMP-binding.1"
                     /evalue="1.20E-39"
                     /label="IQ233_RS23215_AMP-binding.1"
                     /locus_tag="IQ233_RS23215"
                     /protein_end="355"
                     /protein_start="30"
                     /score="128.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ASELYLELQHKLTSGNTPKIILAEREPVRFFAGFIAACAAGCPVF
                     LCNPDWGKQEWQQVLELVQPDIIWGLEIKISPHRISNQSPYIMIPTGGSSGKIKFAIHT
                     WETLIASVQGFTEYFQLTQVNSFCVLPLYHVSGLMQFMRSFTTGGKLAIAPFKTLASSP
                     EYQIAPADFFISLVPTQLQRLLENPQLTQWLSQFTTVLLGGAPAWEELLEKAKFHRIRL
                     APTYGMTETASQIATLKPDDFLNGKINSGQILPHAQVKIRNQQGEILNPYQTGNITIQA
                     QSLALGYYPQTWENQHYLQVDDIGYLDSQGYLSIIGRSSDKIIT"
     gene            complement(19453..19899)
                     /locus_tag="IQ233_RS23220"
                     /old_locus_tag="IQ233_23220"
     CDS             complement(19453..19899)
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011317281.1"
                     /locus_tag="IQ233_RS23220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23220"
                     /product="thioesterase family protein"
                     /protein_id="WP_194003612.1"
                     /sec_met_domain="4HBT_2 (E-value: 2.3e-18, bitscore: 58.3,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFTYNRTIRLQDTDAAGVVYFANALSICHEAYEASLEASNINLK
                     AFFTNPPIAFPIVNASVDFFRPMFCGNKLEISLIPHKLGVNKFEVIYEIMVENVLVAKA
                     VTRHVCIDAISRTKQDLSAEIIQWLETNRHDAEAAERRKLREIL"
     gene            complement(20001..21089)
                     /locus_tag="IQ233_RS23225"
                     /old_locus_tag="IQ233_23225"
     CDS             complement(20001..21089)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-v: HopA1"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196066.1"
                     /locus_tag="IQ233_RS23225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23225"
                     /product="T3SS effector HopA1 family protein"
                     /protein_id="WP_194003614.1"
                     /sec_met_domain="HopA1 (E-value: 8.9e-64, bitscore: 205.8,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNSSTNPLLTSLLDIASNIEIKSNFSIYHPNYQPFALPAKIADR
                     FQQNPAALQHKYLNLLLRNFLYGIYYNGSLQSTLAVNIQTANCLRHQALEANSIVDVDW
                     EFYEQLQTSNHGKGYFDPSWQVLRLEPDGSMAVTKGGLTVYVEPDCHLKPSKKSAQVGE
                     SVAIWMPKNRLQKGCYLAVSNVGQEKQGNPDADLGIGRIYFNFTSSGAIACMDGLTQQL
                     NAANIPFTFQVLYNPAAYGRYDSGILYFERQDYPAIRKILQAVYTEYQSHFQPEIPLFT
                     KFLAPGLSLAEEPTQKFAAQESFGMNRCQIVANALLEAWEKGKNAMEERMRVIDQHFAQ
                     HLIDLQRPYLNPSSEDIYQPLK"
     gene            complement(21124..22362)
                     /locus_tag="IQ233_RS23230"
                     /old_locus_tag="IQ233_23230"
     CDS             complement(21124..22362)
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-v: APH"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196067.1"
                     /locus_tag="IQ233_RS23230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23230"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_194003616.1"
                     /sec_met_domain="APH (E-value: 3.1e-18, bitscore: 58.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLSLSSHNVIQYLQEAGLCCSEDGASNKDDLLKSSPQNLNLLVT
                     LAGNQKLLVKQKLHVENDGTPQEFFNEWLFFQLLQQFPVLGNISAIAPLILHFDEENSI
                     LIRNYLSEYSELGEFYRHNDIFPPEIASAIGTTVAGLHRATFQHREYRNFMATAPEGQF
                     RYSFYNPAQGVDSISPEIFGTVPTEALKFYLLYQRYESLESAIADLAYEWQPCCLTHND
                     LNLNNILIHSRWDQLDNCLIKLIDWEACGWGDPAFDLGTLIASYLGIWLSSLVVDHTIE
                     LEESLHLAMTPLEVLQPSLLALIRAYLNAFPMILEYQSDFIVRVIKFTGLALINQIQAT
                     IKHRKYFGNTDICMLQIAKNLLTIPEQSVLSIFGVSEAKIVKSLAKIHKFPQPEPQQQL
                     VPLYYEKTRLRGC"
     misc_feature    complement(23079..23094)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.16"
                     /tool="antismash"
     gene            complement(23087..23407)
                     /locus_tag="IQ233_RS23235"
                     /old_locus_tag="IQ233_23235"
     CDS             complement(23087..23407)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010996618.1"
                     /locus_tag="IQ233_RS23235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23235"
                     /product="TMEM14 family protein"
                     /protein_id="WP_194003618.1"
                     /transl_table=11
                     /translation="MNSSIIAALTYGILAIIGGIIGYIKANSQVSLFSGIISGFLLILA
                     AYFQIQGQAWALILAVLVTVSLVIFFALRLAKTRKFMPAGLMVILGMLALTFMVNQLLI
                     GR"
     gene            23495..24904
                     /locus_tag="IQ233_RS23240"
                     /old_locus_tag="IQ233_23240"
     CDS             23495..24904
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012409973.1"
                     /locus_tag="IQ233_RS23240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23240"
                     /product="ATP-binding protein"
                     /protein_id="WP_194003620.1"
                     /transl_table=11
                     /translation="MDNPAMPKASSSSYSHSQVQFLQCQAASLLLYQSVMQSEAGIAFL
                     DLLQAIRYTDADARSCLKAYGSYFYALTARYQNWEDYLITQILISDNPFSRLAQQQDFE
                     DLPRALIAAVEHDLQALQNLYECSSASLSEWVQTVAHLPISPVVWYKKPNISIETKLIV
                     FLQKLDNWGDAVEELAAYYRQFGTGLFAEYHALRWQESKFVGIRHSDPIQLNTLVGYES
                     QQETLIKNTEFLLSGEVALHILLYGSRGSGKSSLVKALLNEYGQQNLRLLEVAKSDLQD
                     LPKIVEQLRGVPQKFIIFVDDLSFEEDDDAFKALKVVLEGNLTARPQNVVVYATSNRRH
                     LIREYFVDRPTPKDNNEIHAWDTMQEKLSFSDRFGLTLTFEPADQKTYVKIVHHLAAQA
                     KINITPEDLEYQALQWATRHNGRSGRTARQFIDFLKADLALSHSHTHPSHPSENKTSKK
                     QQLKIDDQPVL"
     gene            25092..26366
                     /locus_tag="IQ233_RS23245"
                     /old_locus_tag="IQ233_23245"
     CDS             25092..26366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015111479.1"
                     /locus_tag="IQ233_RS23245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23245"
                     /product="tellurite resistance TerB C-terminal
                     domain-containing protein"
                     /protein_id="WP_194003622.1"
                     /transl_table=11
                     /translation="MQSAMISNRYILGIVAFSVSFGISLVPNWDLNQALITGIITILAT
                     YAAALFIDKRRSNYEMLVLSSHRKRIKEMEGLKLRLVKEINQIEEHRNLLYAESKKLEN
                     QILDCRNQRDSIHRDLGIFAGQKKQLETESINLIAEIKILEQNQAELHHAFSQLTTEKR
                     RLDLNCNTSRAEIMQLQNQIGGLQQDKQELETNVSLLGRLKPQLEEKMYELRIEIQELE
                     TETNQQKQLLVSTKTERENLAENLNYLQTKIAEKQSELQQIEAQSFLLQSERDLLQSQV
                     WELLQQTETLNQEVLPEDFHENANDLFSFTELIDSSDSIDTTVILPKEWNNFLEILPNH
                     EIQVLKAIVEQDNPKVIIKQIAEANITMPNLLIDSINEHANDTIGELIIEPSLEIPEVY
                     QEHILNARKMLAMYENLIARQASSN"
     gene            26533..27858
                     /locus_tag="IQ233_RS23250"
                     /old_locus_tag="IQ233_23250"
     CDS             26533..27858
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017310715.1"
                     /locus_tag="IQ233_RS23250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23250"
                     /product="ATP-binding protein"
                     /protein_id="WP_194003624.1"
                     /transl_table=11
                     /translation="MAKLKISKKISTALINSLGAGVVPRTGVEHIAVGREKELQSLFQN
                     LDDIAEGVSAFRFIIGNYGSGKSFILQLIRNRAMEQGFVVADADLSSSRRLAGTHNEGL
                     ATYRELMSHLATKTRPDGGALVSILEGWINKIQQEVVKETNLRPNDDGFDDKVEAKIRE
                     VVLYIEDLVHGFDFGSVIIAYWRGYRLDDDDLKNAAMRWLRGEFNTKTESKAALGVRVI
                     IDDDSWYDYIKLFAKFVAEIGYKGLLVLVDEAVNLYQISTTVTRERNYNRLLTMFNDTM
                     QCKAEHLGIFIGGTTRFLEDPNRGLFADQAWRRRTKESRFATQSGVQENSGTVIRLNPL
                     SEGEILTLLQRLTEIHALNFGYEQVLKNPELKDFVQEIVSRLGAEALLTPGEIVRDFIS
                     LLNILHQNPGMAFSELIHGSKFQPTVMGKDADEDDNAAEFSL"
     misc_feature    complement(26546..26560)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.86"
                     /tool="antismash"
     gene            28265..28555
                     /locus_tag="IQ233_RS23255"
                     /old_locus_tag="IQ233_23255"
     CDS             28265..28555
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016875930.1"
                     /locus_tag="IQ233_RS23255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_23255"
                     /product="prevent-host-death protein"
                     /protein_id="WP_194003626.1"
                     /transl_table=11
                     /translation="MKWTLEEAKKQLSSIINATSLEPQLIYTQEELVAAIVDPELFQEF
                     LNWRQNAGKISLDQVFKQVRQLCTEENYSLEIPPRSDRDNPFTDIAIAKVI"
ORIGIN
        1 caattaaatt tatgtatgtt ttgtaaccca ctaaatcagt tgcagatttg agtatttctt
       61 tcacctctgg agacatccac ttggaagcac ctggcccagt gccaataatt gctaaccgtc
      121 cctgtgcttg accgatggtg ctggggtcga ttggtgtggc ggctatggcg atagctaggt
      181 gggaagatga ggaggataag ggagatgagc cagtggtggt gagtgctatg gcttgggacg
      241 ggctataacc ttgtaatgta aaattttcta gttgatttga ggtaaaaaag cgggcaggta
      301 ctttaaaggc gttagcaatg gcttttaagc tgggattatt ggctagggtg attggtgcaa
      361 atattccggc tactgattct ggggcaagtt cggcatctgc tagcagctgt tctactaagg
      421 ctacatcaac ggtatcacta atggcaatta ctatagttgc tgggtgataa acaaggcggt
      481 tggctgaggg agttactaat cgttctgtaa cctggattgt caaatcacca ttggggtcta
      541 taggtagttg actattactc aaccaaggcg ctgaaccttc aagcttaact tgcgcccctg
      601 ctaataaatc tgaaataaat ttcttcgcat catctgggtt ggctaaatga tatccaggtg
      661 gaggagataa taacgcggtg cggaaacgga tatcacctgt ggtagtgatt gcaggtttaa
      721 catcaagcgc ctcagcaata cgtcgcgcca aatcattcac accattcagt ccacccaaaa
      781 gtggaactac cgcactacca tcttcagcta cggctattac tggcggttcc tgttttttat
      841 cggaaagcat tggtgctatt gttctgatca ggataccagc agcacaaata ccaattaacg
      901 gtgttccttc ggcgaataac tcgcgcagtg tttccccaaa attcgtgaag ctaacatcaa
      961 cgccagatgt gcgacctgcc aaaccgtata atgttgcctc tggcaggaca ttgatgattt
     1021 ttcgggctac tggtacactg ttttcaccca gtaccactat ggcaggtgca atctttgtga
     1081 tcatttgatt agatatttta caaaagttga tgtcctttca aatgaaacca cagatggaca
     1141 cagataaaca cagataattt tgcactaaca gtctaatatt tcttcgataa cactctttaa
     1201 atctttttcc ccagggcgtt tagcaaattg ctcatgacta taaatccaaa caagtctgat
     1261 ggtaaaagta gtgacattca ctaaatacat taacctgatt tgtccggaag ctcccttagc
     1321 aaatcgtagt tccaatttgt gaaatgtcca tccttctgtt aattgcatct ttgagggtaa
     1381 aggttcttga cgggagttat aaggatactg ctcttcagtc aaattttcta taatttctac
     1441 catcagttca acaaaactag aaccatgaaa ctttgccaat tttttaaaag aacgctggaa
     1501 attatcagac ttttcaatcg agaagggagt taagccagtc acgcacctct cctttattaa
     1561 tgcgatttga agattctgaa ttacaagcgt cttctaaaac ctgagacatt acagattgaa
     1621 aagcaggatg gtcccgttct attaaatcaa gtttctgata acccaaagcc ttcatatcct
     1681 ccagcaaaat ccgttccgtt gaacttgcat ttgcaggtaa acccttgcgt gcttttgtcc
     1741 aaggaaactc caagtgagtc atattactga gtcgataagc acggtaacca ccaaaatatc
     1801 cccaaatttc ctctaacagc tttttttcat cttgaggaat ctgtaacaac aatttctgac
     1861 taggtatggg taactgctgc gcttcaaatt cactgtaaaa cctgtaagcc ggaggacaga
     1921 caggcccgta tcgccatgct tgaatgtctt cgtcaaacaa tggctgatcg tatattgcta
     1981 aatacaagct ttgtgaatag tagagaagct tttgaacctt catgttggtc atttcggctt
     2041 ctataccgtc ttcgtaagcc ctcgcaataa agtagcgagc tgcgtctaga caatttatca
     2101 tcgttcagac ccgcaaataa aaccaagcat aatatcatag caaattttta atttgcctat
     2161 atacttaatt atagattcaa tagtacagaa atactattta catagcgtgt cgtagacaag
     2221 aattttgttt aacctatagt cgatttttgg tggggatgat aatcattgag aaatagggta
     2281 cttgatcggg atcaacttca tctaggggta ctattctttg ttgtgtggtt gttgccctct
     2341 caatatataa tgcccgtgat gccaagccta attgatgtaa aacatctcgc actttggtga
     2401 aatggcgacc tagtttcata atcgctgctg catcagttgc tagtaagtgc gtaatcaatt
     2461 cttctgctgg catgggggca ggtaaaacgg tcataatatc gttgtaataa gtgaagggta
     2521 cacccaaggc tacaggacaa gccatgagtg aggatattcc cggtacaact tccgtttgat
     2581 agtgttgaga taaacgtgtg aaaacataca tgaaggaacc gtagaaaaac gggtcaccct
     2641 cacacaatac tactacatcc ctgcctgcgg ctagatgttc ggctattggt tcaacttctt
     2701 tgtcataaat taaattggcc gtttctggtt ctaaggcgcg gggaaggtga aacagcacct
     2761 cgatttgatc cccggtgaga tattgggaga cgatcgcgcg cgctatactt tctttatcga
     2821 ctgctgactg ataagccacc acaggggcag cctgtaatag tcgcaatgct ttcaatgtca
     2881 atagttcggg atcacctggc cctacaccaa ttccatagag acggcctttg gtttgcatga
     2941 ttattcttcc tcttttgcta aggcattaac ggctgctgcg gcgatcgcac tgccaccacg
     3001 ccgaccatgt aaagttaaaa atggtacacc tttgctattt gctgctagtg cggcttttga
     3061 ctctgctgca ccaacgaatc ccactggaaa acctaaaatc agcgcaggtt ttagcactcc
     3121 ttcttccagc atttctaaca gccgaaatag tgctgtcggg gcattcccca ctgctaccac
     3181 tgccccttct aagtgcaatc gccacaattc tacggcagca gctgatctcg tattacccaa
     3241 acgtttagcc agcgctggta cttccacatc atagagggtg caaataactt ggttgtttgt
     3301 cggtagtctc ttcctcgtaa tcccttcggc aaccatgcgg caatcacaca aaatcggcgc
     3361 acctgctgct agtgctgcgc gtcccgcctg caccgccgtt gatgaataac ccaagtcagt
     3421 aacgatatca gtcattccac aggcatggat taggcgtaca gctacttttg ctacatctgg
     3481 aggcaggaca tccagcttgg cttcggatct gatgattgca aaggatttac tgtaaatttc
     3541 gttagcatct cggatgtagt cagacatggg aaaatagtga atggtgaatg gtgaatggga
     3601 atggctatgc cacgcaagct aacagaaata accctaactt acagaggaaa ataacgggtg
     3661 taattgggca atctcatatc tattaacaaa ttctccaaag gattcatcag gatttcggca
     3721 ttgaatttta taaacttgta acatctgccc taacaataca ggtagttcgg ccacagtgac
     3781 atattgatag agttgacgac caaatttttg gttgctgtca cctatggctt cgccacgcaa
     3841 gctatcacca acataaatgt gataagctcc cattgttcca ttttctgatt ctaggctgac
     3901 accgagcaag gtaatatcac tatgactatg ctgggcgcaa gatttttcgc agccgctaaa
     3961 atgaatatga actgggtgat ttagactaac atgagtttcc agatactttg ctaatgccaa
     4021 agcatcacct ttagtatccg tggcggaagc tgcacaacct ttattaccag aacaggcaac
     4081 taatgcacta ttgatattac ttgctgagac atctaatttt aaaacagcaa tttcactttt
     4141 gacatcggta agcgatcgcg ccggaatatc tgtcaggagc aaattttgcc aaggagttag
     4201 cctcagagtc ccgttaccaa atctctgggc taaatcagct aaacccctaa tttgctgagt
     4261 ctctagccta cctaaaggta aaaccacgcc aatataaaat aagcctggct gacgctgggg
     4321 atgaataccg atatgttgat agttggagtt tgacctgttt tcgacactgg ttttgtcaaa
     4381 ctgtccctgg gatgtgagtt gaaaacctag acgttgttca acttcttgaa gataacgttc
     4441 acaacccaaa ttatttaata actctcgtaa acgcagcttg cgccgactgt ttgggtcagt
     4501 atagttgaga taaacttcag ccaaagctgc caaaactggc aaacatgact ctggtaataa
     4561 gacaattccc atatcaatgg gtggttttcc tttgacaccg acgctgagat gcagacgaaa
     4621 ataaactcta ccgtcaatta agacagcagc aaacatgata tcgttgaggc gatcgcacac
     4681 cgagactgta ccaccaccat caaagcaaac actaaatttt gccgatagtc ctgatagggt
     4741 gggatgtgcg gcgatataat tttcccagtc ctgcacaaag ggacgagtat caattaattc
     4801 ttggggatca ataccagcag tgggactggt cataatattc cgaatgtggt caacagcgaa
     4861 attgcgagaa ccaataccta tattttgtaa atcctggaga actgctgcat ttattcccga
     4921 acgcagttcc ctgatttgga ggttggcgcg attggtaata tcgacatatc cacccccgta
     4981 attctctgct atatctgcga ttgcatgaca ctgtttacta tccagaattc cacctggtac
     5041 tctgatgcgt gataatatcc catcttgagc gggtgtatca taaaataagc caggacataa
     5101 ggcaaaaccg gacagcaaaa cattaactcc ttccctgtgc gacgcaggca atagatagta
     5161 tgtgtgtctt aaaaacactg ctatagttgg cattctgact tggcaaatgt tctgctttcg
     5221 ctttaccatt acagctgcgg cacagtcccg gaatttcacc ggagtttccc aactcttagc
     5281 ttcagtaatt taacatgatc aggtattcag atcgctggat gcgatctatt ttttatattc
     5341 agttaaactt agcactgggt atatctggag attttattta caacccaatg agtagccctg
     5401 tgacatttct ttgggctaat tacacaacat ttcagtaatt ttattgtact aaatcaacta
     5461 aggtgtcaca ttggaaccgg actacacatg aaactaagca tccacgataa tgctcagatg
     5521 tgaataccga tagtgtgatg ttggtcgaac caggttctaa gatgcgtttc actttgcaaa
     5581 cttgcatctt attcttacag taggcaataa tgcgatcgcc tgctttgaca tccaacgctt
     5641 taattttcaa ttaatactca acctaattat gaaatttaat taactcaagt aaatatatat
     5701 tgctatattt tacctggatt aacagttgta atgcttgttc attataacac acttactaat
     5761 agttatgaaa tgctcaaatt ttggcgctgt ttgacaaagc atcattacag gctatttttc
     5821 caaaaaatga tgattaactg ggattaatcg ccgaaaaagc cgcaaaattt agttaaatta
     5881 ttacagcttc tatgacacgg aaatggttat cgattgtggg tattggtgaa gatggcttac
     5941 aggggttaag tgcgatcgca cgttctctga tagagcaagc tgaagtgatt gtcggaggcg
     6001 atcgccattt agccatgtta cccccaaatg atcaacgcca gaaaatagcc tggacatctc
     6061 ccattagcag ttccatcgcc gaaattatcc gtcgtcgggg tgaatcagtc tgtgtgttag
     6121 ccagtggcga ccctttttgt tacggtatcg gtgtcaccct gacgcgacaa attcccctag
     6181 aagaaattac gattattcct gcgccttcca ccttcagcct cgcctgtgcc aaattgggat
     6241 ggtcttttag ggaaacagaa accttgagtt tgtgcggtcg tccagcctct ctactccata
     6301 gttacatcta tcccaacgct aaacttttga ttttgagtga aggcaaagac acgcctgcaa
     6361 ctgttgccga catcttgaca aatcgcggtt atggtggtag taaaattaca gttttagaac
     6421 atctgggcgg tattcaggaa agaattgtcg aaggtatagc cgcagattgg gataaaagag
     6481 aaattgcacc gttgaatgcg atcgcagttg aatgtattgc taatgctggg gtggtacctt
     6541 tacctagatt accaggattg ccagatcatg cctatcacca tgatggacag ttaaccaaga
     6601 gtgaagtcag ggcggtgact ttagcaaaat tagctcccat tcccggagaa ttactgtggg
     6661 atgtcggtgc gggttgtggt tcaatttcta tcgaatggat gcggactgat tctcgatgtc
     6721 aggcgatcgc cattgaacag aattcttcta gactgggtta catagccaac aacgccgcag
     6781 ctttaggaac tccccacctg aaaattatta gcggtaaagc accatcaatt ctccaaaatt
     6841 tacccacacc ggatgcgata tttatcggcg gtggagtcac agcagcaggg ctgtttgata
     6901 tctgttggaa tgcactgcgt ccgggtgggc gattagtagc taatgttgtc actgtagaag
     6961 gtgagcaaat tttatttaaa tggtatgagc aggttggtgg tagtttaact cgtatcgcta
     7021 ttcaaagagc agaacctatt ggtaaatttt taggttggcg ggcgatgtca cctgttactc
     7081 aatggatagc aataaaacct gaaaactttt aataatagtg aagtgtgcag acaaataaat
     7141 tatttatttt tcgtcccata taattcatgc tatcacactg ttaataattt atctgggcta
     7201 attcatttct aacattctcc agcatcactt gatatcgagg atcttgtaaa ccatttccga
     7261 aatccccatt taaatactgc tgtaaaagtt tctctgccgc tttgtaatct gccattgcac
     7321 tggctttatt atttaaatca cggtacatat tacctctgaa aaagtattga tcagcattgg
     7381 gactactatc accaattaat tgattcaaat cggaaattgc tttctttttt tcccctaact
     7441 tttcataagc cctagcccgg ttccaataag ctcccctact aaaaccaaac ctacctgtat
     7501 tttgcctaat tacttcgcta tggtccgcca ctgcggcttg ataatttccc aggttatagt
     7561 aagcattagc acgatgatag tatgcttctt caccttgagg attgagagta attgcctgtg
     7621 taaaagaaga aaccgcagat tgggagtctt tttcgcagtc ttcttgaaag tgtcccagac
     7681 ctatgaagtc tttgactgta ttcagatacg gtggcttaaa agtttggcac tcactagcag
     7741 cattagaagc tggtatttgt gcaactaacg ggatcgaaaa acctagcagc aaaatagacg
     7801 atgcataagc taacacagaa ggtttagaga atgtaaattt cataatttca accagattaa
     7861 taacgctaat ttaacacaca aaaatttttt cccaagttac taaaataatg aagtatgggc
     7921 aaaacccacc ccatccggtt ttttaggcaa aacctcacgc ctatcaaata tcctctatga
     7981 tgcaaaaact acatcttcgt aaagttctgc tatagtcgcc tcaaagtcta tactatttaa
     8041 tcgaaatgac ttttcttctg ctgtgtagga ttgcaaaacc cacagccctt gaccattacg
     8101 gcgaaaacat tcaactcgct gacgttttgt gttaattaag acgtattctt ctagagtttc
     8161 tagcagctga taatcggcga atttatcccc tcggtcaaag gcttcggtag aatcagataa
     8221 aacttccaca attaaagtag aaaatctttt ataagctggc gtttcttggt ctctttggtc
     8281 gcaagttacc atgacatcgg gatagtaaaa ccgattcagt gattcaattc tggctttcat
     8341 atccgcgatg taaacacgac aacctgaacc acgtacatga ttacggagga gagtagcaag
     8401 gttgagcgca attgtcacat gggaatctag cgcccccgcc attgcgtaga tatagccatc
     8461 aatatactca tgtttaatat cactctgctc ttccatctct aagtattctt caggagtgac
     8521 gtagatttcc ggggaagcaa ccatatttaa aacctcaagg tatagactat attcctgggg
     8581 tttcatcccc aagccagaag ttaacagctt tcctactatc tagcatatac atataaaaac
     8641 gggaaatgta cctcaaagat cacagttgct gttcgcctag cgtcttggag ataggagaga
     8701 taaatgaggt cttaacctac taccgttgtg aaacttgtta tgcatgaatt atgtgagact
     8761 gtattaaaca gtgaagaaaa aattactctg cgtcagttta tcctggaatt aagtgctacc
     8821 gataaacgtt attttttaag aaacgagatt ttacataatt ttgccgactt ttgtcaccaa
     8881 taccaaaagc ctacttactt ttattattct tcttctattg gcagactaat tcataatacc
     8941 catgaaatga ttttagaagc agaaggcaca tggtttgtgg ttcgacccag gattggtagt
     9001 caacaagtgt ggcgactgca aaccgatttc tctggatttg agtcaatgac accccaagcg
     9061 tggttagatg tcagcgatcg cctcgttaat cgctatcaac cgcacattct cgaaattgat
     9121 tttcaacctt tttcggaaga atccactaga atcagtgacc ccagaaacat tggtcaaggt
     9181 ctagcctttc tgaatcgtta cttgtgtaat caactgtcta atgacactca ttattggcta
     9241 gaggtgatat ttcaagcatt atatcggctg acttatgatc aaaaaccgct gctaattagc
     9301 gatcgcattc cctccggtct tcacctagtc aaacaaatta agcaagcctt aaaatttctc
     9361 aatcagcaac ccccagaaga accttacgcc aattttcgtc ctcacctcca agaactcggt
     9421 ttggaaccag ggtggggtaa tacggctggg cgcatatccg aaaccctaga actgttagaa
     9481 caactcattg ataaccccca acccgctatc ttagaagcct ttgtcgcccg tgtccccgcc
     9541 attttccgcg tcgccctcgt ttccatacac ggttgggttg gtcaacagga tgttttaggt
     9601 agagatgaaa cactaggtca agtaatatat gtcctcgaac aagcccgcag tttagaaaat
     9661 aaactccaag cagaaatcaa acttgcggga cttgacttat tagggattca acctcatgta
     9721 attatcctca ccagactcat tcctaactgc aaaggcacag aatgtaattt gcggttagaa
     9781 aaaatccacg atactgaaaa tgcttggata ttacgcgttc cctttggcga atttaattct
     9841 gatattacca acaattggat ttctaaatat gagatttggc cttatttaga aacatttgcc
     9901 caagatgccg agaaagaact attaactcaa ttccaaggtt gtccaaatct gattgtgggc
     9961 aactatagcg acggtaactt agtcgcctct ctcatttccc gcagcctaaa agttacccag
    10021 tgcaatattg cccattcttt agaaaaacct aagcacttat ttagtaattt atattggcaa
    10081 aatctagaag aaatttatca cttttctgca caatttaccg ccgatttaat tagcatgaat
    10141 gcggctgatt ttatcatcac ttcatcctac caagaaattg tcggcacacc agacacaatc
    10201 ggtcaatatg agtcatacaa atgttttacc atgccggatc tatatcatgt gattaatggg
    10261 attgatttgt tcagtcctaa attcaacatg gttccgccag gagtcagtga aaacatcttt
    10321 ttcccttatc accaaaaaga caggcgagat cccgaattta ctacccaagt acaggattta
    10381 ctttttactc gtgaacattc ccaaatcctc ggtcacttag ataaccctaa caagcgccca
    10441 atccttactg ttgcccccat cacctcagta aaaaatctcg cgggattggc ggaatgtttt
    10501 gctaaaaatc gggcattaca agaacgttgt aacctgatta ttattacgag taaactgtat
    10561 ccaaatgaag ccaccaattc aaaagaagta gaggaaattc aaaaactcca tgacataatc
    10621 aatcagtatg aactccacgg aaatatccgc tgtataggga tgcgtcttcc tagccctgat
    10681 ctcggagaag cataccgagt aattgccgat tctcaaggaa tttatgtcca ctttgcccgc
    10741 tttgaatcct ttggtcgcag cattctagaa gcgatggttt ctggtttacc aactttcgtc
    10801 actaaatttg gtggtgctgt ggaaattatt gaagagcgag aagatacttt tcatattaat
    10861 cctacagatt tcaaggaaac agcaaatcaa attttgagct tcattgatga atgtgagact
    10921 caaccccatt actggcagaa agtttccgat tccatgagtc agcgtattct taataaatat
    10981 aattggcagt taaacaccag tcaaacacta ttgttggcga aaatatttag cttttggaac
    11041 tttgccgctc cggagaataa cgccgctaaa catcgctatt tagaaacctt atttcaccta
    11101 atttttaaac ccagagcgga aaagatttta gaagaacata tgcaacgttc tctcgtcatg
    11161 caaaattgaa aattctgcat tgctaattgt gaatttagca aaggtattca cgatgaataa
    11221 aaaaactcct aataaccatt ttatctatac agattggata ttaattgaaa ctcattttga
    11281 cccagaacaa ttgcattcta gagaaaccat ctttacaatt ggcaacggat acctgggaac
    11341 acggggcagt tttgaggaag gttatattcg tgcattacca gctactttca tccatggtgt
    11401 ctatgatgat gttcctgtag tttatacaga actcgccaat tgtcccgact ggctaccatt
    11461 ggtattgagt atcaatggcg acaaatttcg tttggatcag ggggagatat taaggtatga
    11521 tcgacaacta gatttacgtc agggtatttt ttcccgttct ttgcgttggc gcagtcccag
    11581 cgggaaaact gtagatattc actttgaacg ctttgccagt ttagctgacc agcacgtatt
    11641 ggggcagcgc tgtcaagtaa cgcctgtaga ttttgatgga atgattgaaa ttcaggcgag
    11701 tattaacggc tacccagaga atcagggttt taatcattgg gaagcaatcg accagggtaa
    11761 aactgaacaa ggaatttggt tacacagccg gactcgcggt tcccggatcg atattggcat
    11821 ggcggcaagg atggtaatat cgggaactga ggcagcttta gaagtgcata ctgcccctgg
    11881 ctaccctacc ttaactgcaa ccttcctggc tacatcacag cagacggtga cagtagagaa
    11941 gactgtgaca gtttttacct cacgggatgt ttcccaacca gtgccagcag ctcaagaaaa
    12001 actcgcgcaa ttgccagact atataacttt gctgcaagcc aacgcccaag catggaatga
    12061 ggtttggcac tatagcgata tcgtgattga gggagatagt aaagctgctt ttgctgtgcg
    12121 ttacaatcta tttcaactgc tgatttctgc gcccaagcat gatgaaaaag tcagcattcc
    12181 cgctaaaact ttgtcagggt ttggctatcg tggtcatatt ttttgggata cagaaatttt
    12241 tattctgccc ttttttactt tcacccaacc tgctttagcc cgaaatttat taagttatcg
    12301 ttaccacact ttaaatggtg cgcgacgcaa ggcatcccat tatggttata aaggggcgat
    12361 gtatgcttgg gaaagtgcgg ttacagggga tgaagttaca ccacgttggt cacttcctag
    12421 cgatttttac ggtgaagata tcagaatttg gtgtcgtgac cacgaaatac acattagttc
    12481 agatatttct tatgctgttt ggtattactg gcaagccacc ggcgatgatg aatggatgca
    12541 aaagtgcggt gctgagatta ttttagatac agctgtcttt tggaatagtc gagttgagtt
    12601 taattctgaa caagaccgct atgaaattcg gggggtaatt ggagcggatg aatatcacga
    12661 gtttgtccat aataatacct ttactaatcg gatagtgcag tggcatttag aaaaagcttt
    12721 gatagtcaat gattggctgc atcaaaattt cccagaacga gctaaggaat tagaggataa
    12781 attacaactc acggctgaga taaaaaccca gtgggaagat atcgtggcta aactttggat
    12841 tccttacgat gctgaaacgg gattaattga acagtttgag ggatttttcc agttggaaga
    12901 tattaactgg aatgactatg aaccacgcac ccagtcgatg caagggattt tgggtattga
    12961 aaaaaccaat aaattgcagg tactcaagca gccagatgta ttgatgctgt tgtacttaat
    13021 gcgggaatta ggagattttc cttacaatca aaaatcatta caagcaaatt gggactacta
    13081 cgcaccccgc actgatatta cttatggttc atcacttggc ccagcaattc atgccatttt
    13141 agcttcagat ttaggcaagt cggctgaggc ttacgaacgg tttatgcaag cagcaatggt
    13201 ggatctcgaa gatatccgtg gtaacgctgc cgatggtatt cacggggcga atgcgggggg
    13261 aatttggcaa gctgtggtgt ttggttttgg tgggattaaa ctgagagaca gtcgccctct
    13321 ggccaaccct catttaccca ggggttggac acgcctgaag tttaaactgc actggcgcgg
    13381 taaatggcat gagtttgatt tacgtcccca aatcactcag gaggaaagta acaaaggatt
    13441 tattttattt gctccttcat ctccccacac ttctaaaatc caaggggtga tatttgattt
    13501 agacggcgtg ttaactgata cagcagaata ccactatcaa gcttggcaga aattagcaga
    13561 tgaggaggat atcgaattta atcggcaagc taatgaggcg ttgcggggta tatctcgtcg
    13621 ggcttctctg atgcggatta ttaagaataa aaaatattca gaggcagaaa ttcaggaaat
    13681 gttggagcgt aaaaacggct actatgtgga tctaattgaa aatattacac caaaagatgt
    13741 gttgccaggt gcgatcgctt tattggatga attgcgacaa caggggataa aaatcgccat
    13801 tggttcagcc agcaaaaatg cccaggtggt tgtagagcgt ttgggaattg ctgatcatgt
    13861 agatgcgatc gcagatggtt atagtgtaca acaaccgaag ccagcccccg acctgttttt
    13921 gtatgcagcc gagcaattag gcgttccacc agatcaatgt gtggtgattg aagatgcggc
    13981 ggcgggtgta gaagctgctt tagcggctgg gatgtgggct gtaggtttag gcccctcaga
    14041 acgcgtcggt gcggctcatg ttgttctgcc tagtttagca ggtgtgaagt gggcagagtt
    14101 gcaagacaaa ttgagggaag ctgtggcaca gaaatattga ctttctacaa attttatttg
    14161 gattaacgaa ccgccaaggt gccaagttcg ccaagggaag agggtaagtt ttttaaggga
    14221 gataatttta tgtctaaatc tggaagaaca cgggaaatac tgcaatcaat gagaaatatt
    14281 cctcagcaag taatgaacta tatctcagaa gcagtcagca gaatcttcag ccccagagac
    14341 gacaactatc cagccacagg agttcaaccc tttgaaggcg atccccctga caaaaaaaac
    14401 gactaaaacc tccgcgtacc tttgcgtacc tctgcgttta aaccaaagcc ttcagcaaag
    14461 cctgaagttt cagttgcacc tcagcaaact ctttctcagg atcagaacca gccacaatcc
    14521 cagcaccagc atacaacctc gcgcgatcgc catcaattaa agccgaacga atccccacaa
    14581 taaactcaca gttaccgcta gcatctatcc aacccagagg cgcagcatat aaaccccgct
    14641 caaaactttc ataacgacga atttctgcac aagcaaaatc tctcgttgca cccgccacgg
    14701 ctggagtagg atgcaattgg gaaacaatct ttaacgggtg gacattagcg ctaactttgg
    14761 ctgtaattgg tgtccataaa tgctggatat tagataattg tctcaggcgc ggcgctaata
    14821 cttcgggtaa caaacctaac tgggtgaggc gttgagtaat gaaatcaatt actagagaat
    14881 gttcatgtct ttctttgata ctatttaata accgattggc attagcggca tcttcagcag
    14941 gtgttttacc tctgggtgca gaaccagcta aagcatcgga aattaactct tgattatgaa
    15001 tactaattaa tctttctgga ctcgcaccaa tgaagttttg tcccttacca ttgctagtag
    15061 aaaaaatata acaattagga tgtatttgcc gtagattgtt taatgatttg aataaattaa
    15121 aaatatggct ggattttaca tctaaggcat ttgctaggac aattttaatt aaatggctag
    15181 accgaatttt ttctacggct gatcccacag atcgtttaaa atcttgagga ttagtgacag
    15241 attgtttact aaacttattg ggtaactgtt ctaaatttgg agcagcatat tctaaagact
    15301 gaatttgagc aattttatgc tgcaaatcct gcaatatact ttctacattg gtgctgggtt
    15361 tgataattat attgttgact aatatgcaat gttgattttt aactgatatt tgccaacggg
    15421 gaagaaaaac tgtagccgat ggaaaagggt aatctatttg agaattataa tcaaaaaagc
    15481 cgaaataaca aaaaaagtga ggtcccgcaa atgttggctg attgttacca aaatttataa
    15541 tattttttag acaaaatttg ataaaatgtt cagcttgatg aaaacgctct ttgccatcaa
    15601 tttctaattt tgtcacagta tcaatggccg cgatcgcttc tcctttagct tgattctcaa
    15661 agtaaaaatt tatttcattt gcttgcgtaa gtttatctaa tacaactaag ggatctaccc
    15721 agtcaatatt cagcgaaata ctcacaattt gccgacaatt atgcttgagg caattttcct
    15781 gaacgtttaa cagaaaatgg tataggtctt tgtttttgac aaagaagttg ctgcgacatg
    15841 gtaaaactgt catggatcta gcaatagtaa acttttttta agttaacttc ctaaagtgta
    15901 attaaacgtg gtcgtatttc tacaggtaac atattcagtt gccacttcac cagagtatgg
    15961 tttgctgtat ttatggtgtt cccagacgct gaacagctat ccttagtttt gggttgtatc
    16021 caaaaagtga gtgttactaa cgagaggtta accagccaca gcaaattccc taagtttggc
    16081 acttaaccag tatttagtaa accccagagt tccagcgcta caaaatcact gttgaatggc
    16141 gcggggcggt gctggtgtct ctcgaaactg taaaatttta tgtataagta aggttactgt
    16201 aatctcatga atcacgactg atgacgacaa aacagattgt aaatcctcaa attaaattat
    16261 ggatggcggc aattaaaccg ccaatgtata gcgttgcgat catgccgatt tgggtaggaa
    16321 cagcagtggc ttttgcggaa accaatagtt ttaatgtagt agtattttct acttttatcg
    16381 ctgcggcaat tttaatttta gcttgggaaa atatcagtaa tgatgtcttt gattcagaaa
    16441 cgggtattga cgaaaacaaa catcattctt tagtaaattt aactggaaat aagctattaa
    16501 tattttggtt aggaaacttg tgtttggttt ctgggttgtt gggaataatc gcgatcgcta
    16561 tttggcaaaa agaccccact gtcatcggct taattctgct gtgctgcgct ttgggctaca
    16621 cataccaagg gcctcccttt cgcttaggat accagggttt gggcgaaatt atttgttttt
    16681 ttgcttttgg ccctttggcg atcgccgccg catactatag ccaaacggca agttggtcaa
    16741 taaatagttt agcagcgtca gtgattgtgg gcattgctac cagcttagtt ttattttgct
    16801 cacactttca ccaagttaag gatgacatag ccgcaggtaa gcgatcgcct gttgtgcgtc
    16861 tgggtacggc aaaagctgca aaacttctct cttggtttac gggcggtatt tatcctctga
    16921 ttttactatt tgtgttattg gggatgttcc ctgtttggac tttgctgagt tggttgagtt
    16981 taccttatgc gttccagtta tgtcgccatg ttcagcaaaa tcatcatctg ccggaaaagg
    17041 tgagtaattg taagtttatt gcggttaatt tacatttttg ctgttgttcg ctgttgggtt
    17101 tggggtttat gttggggggt tgataagaaa tttttatcac gcagaggcgc agaggcgcgg
    17161 agagggagag gtgagaggtt atcaatttga ttttcgttgt tatcggcggc gctttttaca
    17221 gccattggtt actaatcatg ggttgtggca tacccgtgag gggataatcg tttgtctggg
    17281 taactgtggt tacggggaaa ttgcccctat tagttggttt ggttcggaaa ctctagaaca
    17341 ggctttaaat ttttgtcgcc aattacccgc agaagttaca gaggaaatga ttttctctat
    17401 cccggatagt ttaccagctt gtcaatttgg ttttgagtca gctttgggag gaatggggag
    17461 tggggaagac aagaaatata cccaatttct gacttatagt ggtttactac cttctggaga
    17521 ggcggcttta agtgaatggg aaaggctgtg gaaggaggga tatcgcacgt ttaaatggaa
    17581 aattggggta aatgcaattt ctcaggagtt ggaaattttt gacttactaa cgcgtacttt
    17641 accacctgcg gctaaattgc gcttagatgc taatggtgga ctgagttatg aggaagctaa
    17701 acggtggctg gggatttgtg acgatatttc ggcaaatatt gagtttcttg aacaaccatt
    17761 gcctgtggaa cagttttcgg agatgttgga attgagtgct ggttttagaa ctgcgatcgc
    17821 cttagatgaa tctgtagcca cactcaagca acttgaggaa tgctggcaac aaggttggcg
    17881 aggaattttt gtgattaaac caggtatagc cggttcaccg tctcgtctgc ggcaattctg
    17941 ccaacaacat caaattgatg cagtattttc gtcagtcttt gaaacagaaa ttggcagaca
    18001 agcagcactc caactagcag cagaattatc tctgacaaat agggctgttg gttttgggat
    18061 aaatcatttt ttagaaccag cagaaaaacc ggaatttaaa tgtccataga attacctata
    18121 ttttatctaa accaactggc tgaaaaagat tttatcattg gtgacaataa tcatcaattt
    18181 cagcaaatag cctcagaatt atatttagaa ctacagcata aattaacttc tggaaatact
    18241 ccaaaaatca tcttagcaga acgtgaacca gtgcgatttt ttgcaggttt tattgccgct
    18301 tgtgctgctg gttgtccagt ttttttgtgt aaccccgact ggggaaaaca agaatggcaa
    18361 caagttttag aattagtaca acctgatata atttggggac tagaaataaa aatatctcct
    18421 catcgcatct cgaaccaatc cccatacatc atgattccca caggtggttc atcgggaaag
    18481 attaaatttg ctattcatac atgggagact ttgatcgcat ctgtgcaagg atttaccgaa
    18541 tattttcagc taacacaagt caattccttt tgtgtcttac ctctatacca tgttagtggt
    18601 ttaatgcaat ttatgcgatc cttcaccact ggaggtaaat tagctatcgc accatttaag
    18661 actttagcat caagtccaga ataccagatt gcacccgcag atttctttat atctttagta
    18721 cccacacaat tacaacgctt actagaaaac ccccaactaa cacaatggct atcccaattc
    18781 accactgtac ttttaggagg tgcgccagcg tgggaggaac tcttagaaaa agcgaaattt
    18841 caccgcatcc gtttagcacc aacctatggg atgacagaaa cagcatctca aattgccacc
    18901 ctcaaaccag atgactttct caatggtaaa attaacagtg gtcaaattct ccctcatgca
    18961 caggtaaaaa ttcgcaatca acaaggtgaa attttaaatc cctatcaaac cggaaatatt
    19021 accattcagg cgcaatcatt agccctgggc tactatccgc aaacttggga aaatcagcat
    19081 tatttacaag tagacgacat aggatattta gattcacaag gatatttaag tattatcgga
    19141 cgtagcagcg acaaaattat cacaggcgga gaaaacattt acccagtaga aattgaagcc
    19201 gcaatcagat caactcaaat ggtaactgat gtttgtatca tcggcttacc agataaacac
    19261 tggggagaag cagttacagc catttatatc cccaaacatc cccagatttc tagcttaaaa
    19321 ctgcaagcag aacttcagaa aaaactgagt aaattcaaaa ttcccaaaca ctggatttcc
    19381 gtacccacct taccgcgaaa tccccaagga aaaatcaacc gtcaagaact gcaaaaaata
    19441 gccgcagaac atctacaaaa tctctcttaa ttttcttctc tccgcggcct ctgcgtcgtg
    19501 gcggttcgtt tccaaccact gaattatctc agcagacaaa tcctgcttag ttctactaat
    19561 tgcatcaata caaacgtgtc tagtaacagc cttagcaacc agcacatttt caaccattat
    19621 ttcataaata acttcaaact tattcacacc tagcttgtga ggaattaaac taatttctaa
    19681 cttattcccg cagaacatcg gtcgaaaaaa atccacacta gcattaacaa tcggaaaagc
    19741 tataggtgga ttagtaaaaa atgccttgag attaatattc gatgcttcta gagatgcttc
    19801 ataagcttca tgacaaatag acaaagcatt agcaaaataa actactccag cagcatctgt
    19861 atcttgaagg cgaatagtcc ggttataagt aaaaggcatt atttaataat tcgtaattcg
    19921 taatttgtaa ttcgtaatta gaaaaaccag cttgatcata atacgccaca aatcaacaca
    19981 aataaatatt agcttacgaa ttatttcaaa ggttggtata tatcctcaga actggggttg
    20041 aggtaaggac gttgcaaatc aatcaaatgc tgggcaaaat gttggtcaat caccctcatg
    20101 cgttcctcca ttgcattttt ccctttttcc caagcttcca ataaagcatt cgcgacaatt
    20161 tgacaacggt tcattccaaa actttcctgt gcggcgaatt tttgggttgg ttcttcagct
    20221 aaactcagtc ctggggctaa aaacttggta aacaaaggta tttccggttg gaaatgagat
    20281 tgatattctg tataaacagc ctgaagaatt ttgcgaatgg ctggataatc ctggcgttca
    20341 aaataaagta tccctgagtc atagcgtccg tatgcagcag gattatagag aacctgaaaa
    20401 gtaaaaggaa tattagctgc attcagttgc tgggtcaatc catccatgca agcgatcgca
    20461 cccgatgaag taaagttaaa atagattctg cctataccca aatccgcatc tgggttacct
    20521 tgcttttcct gtcccacgtt gctgactgct aaataacagc ccttttgcag tcgattttta
    20581 ggcatccaaa tcgctactga ttcccccacc tgggcagatt ttttactcgg tttgagatga
    20641 cagtctggtt ctacatatac tgtcaaaccg cctttagtta ctgccatact accatccggt
    20701 tccagacgca atacctgcca actggggtca aaataacctt taccgtgatt gctggtttgt
    20761 agttgttcgt aaaattccca atctacatcc acaatagaat tagcttctaa agcttggtgt
    20821 cgcaagcaat tagcagtttg aatattaaca gccaaagtgc tttgtaagga accattgtaa
    20881 tagataccgt acaggaaatt tcgcagtaat aaatttagat atttatgctg taaagccgca
    20941 ggattttgtt gaaatctatc tgctattttc gctggtaaag caaacggttg ataattggga
    21001 tggtaaattg aaaagttgga cttaatctcg atattactcg caatatcaag cagagaagtt
    21061 agcaatggat tggtagaaga atttagcatt aattagtccc ggataaatca aataaaactt
    21121 taattaacaa ccccgtaggc gagttttttc gtaataaaga ggaaccaatt gctgctgtgg
    21181 ttcaggttgg gggaatttat gaatttttgc caaagatttg acaattttcg cctcagaaac
    21241 cccgaaaata ctcaataccg attgttctgg tatggtaagg agatttttcg caatctgaag
    21301 catacaaatg tcagtattgc caaaatattt acgatgctta atagttgctt gaatttgatt
    21361 aatcagcgcc agtcctgtaa acttgatgac tcgcacaata aaatcactct gatactccaa
    21421 aatcatggga aaagcattca gataagcccg aattaacgcc agtaatgaag gttgcagtac
    21481 ctctaagggt gtcatggcta aatgcagcga ttcttctaac tcaatggtat gatctaccac
    21541 caaactggaa agccaaatcc ctaaatagct ggcgatgaga gtacccaaat caaaggctgg
    21601 atctccccaa ccacaagctt cccaatcaat caatttaatt aaacaattat ctagctgatc
    21661 ccaacgagaa tgaattaaga tgttatttaa gttaaggtca ttgtgagtca agcagcaagg
    21721 ttgccattca taagccaaat ctgcgatcgc tgattctaaa ctctcataac gttgatagag
    21781 aaggtagaat tttaacgcct cagtcggaac tgtaccaaat atttctgggc taatagaatc
    21841 taccccttgc gccggattgt aaaagctata gcgaaactgt ccttcaggcg cagtcgccat
    21901 aaagttacga tattctcgat gttgaaaagt cgcccgatgt agtcccgcta ctgtcgtacc
    21961 aatggcgcta gcaatttcag gcgggaaaat atcattgtgg cgataaaatt caccgagttc
    22021 ggaatattca cttaaataat tacggataag tatcgaattt tcttcgtcaa aatgtagtat
    22081 taatggtgcg atagctgaaa tgtttcctag aaccggaaac tgttgcagca attggaaaaa
    22141 cagccattca ttaaaaaact cctggggagt tccatcattt tcaacatgaa gtttttgttt
    22201 aaccagcagt ttttgattac ctgctaaagt cactagtaaa tttaaattct gcggactact
    22261 ttttagcaag tcatctttat ttgatgctcc atcttctgag caacatagac ctgcttcttg
    22321 cagatactgg ataacgttgt gagaagacag tgataataac atatgctatg tcctacttcg
    22381 taaaattgct gataaaatta ccattaattg agatgaatta gctttagcag tttcggtaga
    22441 cagcaacaat tgcttccata tattaatatc tcatttgtca gattaaaacc tgccattatg
    22501 gcaagataag ttgaattttt actttagatt acgctgctaa tcactataaa atatttaaat
    22561 ttaactaccg ataaacaaca aataaacacc tacctagaga tggatattat cggatttaag
    22621 cattgattct tcactgaggt tttttacttt tattgatatg atgctgccaa ataaagtagt
    22681 catcacaaca attcatctca ttttcagtgc ggttgaccat tcactaatta gtattctcaa
    22741 taggtagagt agaatcactg agatcctcaa caccgggaaa attatataca gtcttatttt
    22801 tatttatcat caccaactca aaaaaaccgg atgttttccg ccgttagtca ttattttgtg
    22861 accaaatatt aatcatctat attgccgaac cgctgtaatg ttacatttgc caccaaaaca
    22921 agtactggga gagagagaaa gaagtgaaat gagggaggca atactgaaac gcaacagctt
    22981 agttctttat ctcgtgacaa atctaacgtt atatagtata aatgtattgt aaaaaataat
    23041 ttactttgag tggaatatct acttaaaaac tggatgagga taatgattat ctaccgataa
    23101 gcaattgatt caccatgaag gtcaatgcca acatccccaa aattaccatc aatcccgccg
    23161 gcataaactt acgtgtttta gctaatctca atgcaaagaa aattactaaa cttacggtaa
    23221 ccaaaactgc taaaatcaaa gcccaggctt gaccttgaat ttgaaagtaa gcagctaaaa
    23281 ttagtaaaaa accactaata ataccactaa aaagcgaaac ttgactatta gccttaatgt
    23341 agccgatgat gccaccaata atcgctaaaa tgccataagt aagtgcagca attatacttg
    23401 aattcattgt taaaacctct ggagattctg attttgctgc cagagtcggc agacattcga
    23461 ccatagccct ttagctcaac tacccagtta attgatggat aatccagcaa tgccaaaagc
    23521 cagtagttca tcctatagcc atagccaggt acaattcctc caatgtcaag cagcatcact
    23581 tttactctac caatctgtca tgcaaagcga agcggggatc gcattccttg acctgttgca
    23641 agctatacgc tacactgatg ccgatgcacg gagttgtctt aaagcctatg gtagttattt
    23701 ttatgcctta actgctagat atcaaaattg ggaggactac ctcattactc aaattctgat
    23761 ctctgataat ccttttagta ggctagctca acagcaagat tttgaggatt taccccgtgc
    23821 tttaatagcc gcagttgagc atgatttaca ggcgttgcaa aatctttatg aatgtagcag
    23881 tgcttctttg agcgagtggg tacaaactgt cgcccattta cccatttcac ctgttgtctg
    23941 gtacaaaaaa ccaaatatca gcatagagac aaagttaatc gtgttcctac aaaagttaga
    24001 taattggggt gatgctgtag aagagttagc agcttattat cgtcagttcg gcacgggctt
    24061 atttgcagaa tatcacgctt tgcgctggca agaaagtaag tttgtgggca ttaggcattc
    24121 tgatcccatc cagctgaata ctctggtggg ttacgagtct cagcaagaaa ctttaatcaa
    24181 aaatacagaa tttttattat caggagaggt agcactgcac atactacttt acggtagtcg
    24241 ggggtcggga aaatcttcct tggtaaaagc tttgttaaat gagtatggac agcagaatct
    24301 ccgcttgctg gaagtcgcta aatctgactt gcaggattta ccaaaaattg tcgaacagtt
    24361 gcggggagta ccacagaaat ttattatctt tgtcgatgac ctttcctttg aagaagatga
    24421 tgatgctttt aaagcactga aggtagtttt agaaggaaat ttaactgcac gtccccaaaa
    24481 tgtagttgtc tatgctacct ccaatcgccg ccacttgatt cgggagtatt tcgtagatcg
    24541 accaacgccc aaggataaca acgaaatcca tgcctgggat acaatgcagg aaaagctatc
    24601 atttagcgat cgctttggtc tcactctcac ctttgaacca gccgatcaga aaacttatgt
    24661 aaaaattgtc caccatctag cagcccaagc caaaattaat attactccag aagatttaga
    24721 atatcaagca ttacaatggg caactcgcca caatggtcgt tctggacgta cagccaggca
    24781 gtttattgat tttttaaaag cagatttagc actatctcat tcccatacac atccatctca
    24841 tccctcagag aataaaacat caaaaaaaca acaacttaaa atcgatgatc aacctgtcct
    24901 ctaggctttt ttactatttg actcttgcct ggggatacta gttataaaat taattagttt
    24961 gtgatgattt tttattcccc cacaaattgt acaaatactt aaaattaaag ctttctcaat
    25021 catagtaatc agtcgtaatg gcattaacaa ctacctattc tgataactca acgacgctaa
    25081 aaaaaaccaa tatgcaatca gcaatgatca gcaatcgata tattctaggc atagttgcct
    25141 ttagtgtgag ttttggcatt agtctcgtcc caaactggga tttgaatcaa gccttgatca
    25201 caggtataat tactatactt gctacctatg cggcagcatt atttatagat aagcgtcgta
    25261 gcaattatga aatgctggtt ttaagttccc accgcaagcg aatcaaagaa atggagggac
    25321 ttaaactccg ccttgtcaaa gaaattaacc aaatagaaga gcatcgaaac ttattatatg
    25381 cagagtctaa aaaactagaa aatcaaatat tagattgccg aaatcaaaga gatagtatac
    25441 atcgagattt aggcatattt gctggacaaa aaaagcaatt agaaaccgaa agtattaact
    25501 taattgctga aatcaaaatt ctcgaacaaa atcaagcaga actgcatcat gctttttctc
    25561 aactcacaac cgaaaaacgt cgcctggatt tgaactgtaa tacatctcgt gctgaaatta
    25621 tgcagttgca aaatcaaatt ggcggactcc agcaagacaa acaagaactt gagactaatg
    25681 tcagtctgct aggtagacta aaaccccaac tagaggaaaa aatgtatgaa ctgcgaattg
    25741 aaatccaaga actagaaacc gaaactaacc agcagaagca attgttagta tctacaaaaa
    25801 ctgaaaggga aaatttagcc gaaaatctca attacttaca aactaaaatc gcagaaaagc
    25861 aatcagaatt acagcaaatc gaagcacaat cctttttatt gcaatccgaa cgagacttat
    25921 tgcagagtca agtttgggaa ttactccaac aaacagaaac attaaatcaa gaagtcttac
    25981 ctgaagattt ccatgaaaat gcaaatgatt tgttttcttt tacagaatta attgattcct
    26041 ccgattcaat agatacaaca gtaattttac ctaaagaatg gaataatttt ttagaaatcc
    26101 tccccaatca tgaaatccag gtgttaaaag ccatagtaga acaagataac cccaaggtaa
    26161 ttattaaaca aattgccgaa gccaatatta ctatgccaaa tctattaatt gattctataa
    26221 atgaacacgc caatgatact attggagaat taatcattga acctagtttg gaaattcctg
    26281 aagtgtatca agagcatata ttaaatgcca gaaaaatgct ggctatgtat gaaaacctca
    26341 tagctagaca agcttcatca aattaaagta ggttgggttt ctttccaagc cacgtactac
    26401 gagtcgggaa acccgcccaa cgcagtggct ccccaatcta ccaaaataca ttttattaga
    26461 agtattaatg caaaattaat attcagtgta tctcctatac ctctgcgttg aaaatgcaat
    26521 taaataaact atatggctaa actcaaaatt tctaaaaaaa tttctactgc tttaatcaac
    26581 tctctcggcg caggagtagt accgagaaca ggagttgagc atattgcagt ggggcgagaa
    26641 aaagaacttc aaagcctatt tcaaaatctc gatgacatcg cagaaggtgt atcagcattt
    26701 cggtttatca ttggtaacta tggctcaggt aaaagcttca tcctccaact aattcgcaac
    26761 cgcgctatgg agcaaggttt tgtggtagct gatgctgatt tatcttcctc acgccggtta
    26821 gcaggaaccc acaatgaagg tttagcaact tatcgcgaat taatgagcca cttggcgaca
    26881 aaaactcgtc ctgatggtgg tgctttagtt tccattttgg aaggatggat taataaaatt
    26941 caacaagaag ttgtcaaaga aacaaatttg cgtcctaatg acgatggttt tgatgacaaa
    27001 gttgaagcta aaatcagaga agtagtgctg tatattgaag atttagtaca tggttttgat
    27061 tttggtagtg taattattgc ttattggcgt ggctatcggt tagatgatga tgatttaaaa
    27121 aatgcagcta tgcgttggtt gcggggagaa ttcaatacta aaactgaatc gaaagcagcg
    27181 ttaggagttc gggtaattat tgatgatgat agttggtatg actacatcaa actatttgct
    27241 aagtttgtgg cggagattgg gtataaagga ctgttagttt tagttgatga agctgtaaat
    27301 ctataccaaa tatcaactac agtcacccgt gaaaggaatt ataacagact gctaaccatg
    27361 tttaatgaca ccatgcaatg caaagccgaa catctgggca tttttattgg tgggacaacc
    27421 aggtttttag aagaccccaa tcggggactt tttgcagacc aagcttggcg cagacgcaca
    27481 aaagaaagcc gttttgctac acagtcaggt gttcaggaaa attcagggac agtcatccgc
    27541 cttaacccat tgagtgaagg agaaattctc acacttttgc aacgcttaac tgagattcat
    27601 gcactcaatt ttggttatga gcaagttttg aagaatcctg agttaaagga ttttgtccaa
    27661 gaaattgtct ctcgtttggg tgcggaagct ttacttacac caggggaaat tgtccgggat
    27721 tttattagtt tgttaaatat cctgcatcaa aatccaggaa tggcttttag tgaactaatt
    27781 catggttcta aatttcagcc cactgttatg gggaaagatg ctgatgagga tgataatgca
    27841 gcagagttta gtttgtgaat attgttatac caattatttg tgaggctgca tattatttcg
    27901 accccacccc taaccccttc ccgcaagcga ggaggggaac tggatttcta gttaaattct
    27961 atttatacat ctttatatta aattggtatt atttcctaac gtatcaatat taaaacccga
    28021 ataagttatt aaaagttaaa caaaggtaat taatgcaatt cacttcttaa tcaaaggctt
    28081 aagcatctat ttgagacgct acgcgttagc ggaacttacg cctacggcat actacgtatt
    28141 agcggagctt tagcgttagc gatacactac aaacctgtaa ttatttacgc taagatagga
    28201 acctgaaatc aatgaatcaa gcagtaaccg ctattctcta tttcaaacat tggagatttt
    28261 tagaatgaaa tggacgcttg aagaagccaa aaaacagcta tcctcaataa ttaatgcgac
    28321 aagtcttgaa cctcagctaa tctacactca agaagaatta gtggctgcaa ttgtagaccc
    28381 tgagcttttt caagaatttt taaactggcg acaaaacgct gggaaaatat ctctagatca
    28441 agtatttaaa caagttcggc agttatgcac tgaggaaaat tatagcttag agataccacc
    28501 acgcagcgat cgcgataatc cttttactga tatagcaatc gccaaggtaa tttaagcata
    28561 gaatgtaaca ataccttttt ctatggaggg aggcgatcgc tatatgccca agtcgtacag
    28621 ttacgacctt cgtcaaaagg tcatccaagc tatcgaa
//
