LOCUS       NZ_JADEWH010000017     20450 bp    DNA     linear   CON 23-DEC-2023
DEFINITION  Nodularia sp. LEGE 06071 N071000017, whole genome shotgun sequence.
ACCESSION   NZ_JADEWH010000017
VERSION     NZ_JADEWH010000017.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nodularia sp. LEGE 06071
  ORGANISM  Nodularia sp. LEGE 06071
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Aphanizomenonaceae; Nodularia.
REFERENCE   1  (bases 1 to 109554)
  AUTHORS   Castelo-Branco,R., Eusebio,N., Adriana,R., Vieira,A., Brugerolle De
            Fraissinette,N., Rezende De Castro,R., Schneider,M.P.,
            Vasconcelos,V. and Leao,P.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-2020) Cyanobacterial Natural Products, CIIMAR,
            Terminal de Cruzeiros do Porto de Leixoes, Matosinhos 4450-208,
            Portugal
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: SPAdes v. nov/18
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 30x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/23/2023 19:29:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,867
            CDSs (total)                      :: 4,805
            Genes (coding)                    :: 4,703
            CDSs (with protein)               :: 4,703
            Genes (RNA)                       :: 62
            rRNAs                             :: 6, 7, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 3, 3 (5S, 16S, 23S)
            partial rRNAs                     :: 4 (16S)
            tRNAs                             :: 42
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 102
            CDSs (without protein)            :: 102
            Pseudo Genes (ambiguous residues) :: 0 of 102
            Pseudo Genes (frameshifted)       :: 22 of 102
            Pseudo Genes (incomplete)         :: 84 of 102
            Pseudo Genes (internal stop)      :: 12 of 102
            Pseudo Genes (multiple problems)  :: 15 of 102
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:23:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 73475
            Orig. end                         :: 93925
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADEWH010000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20450
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20450
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20450
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10450](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10450
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(413..426)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.71"
                     /tool="antismash"
     gene            633..782
                     /locus_tag="IQ233_RS20990"
                     /old_locus_tag="IQ233_20990"
     CDS             633..782
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006195831.1"
                     /locus_tag="IQ233_RS20990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_20990"
                     /product="PsaJ protein"
                     /protein_id="WP_194002767.1"
                     /transl_table=11
                     /translation="MAQPNKEKAYFIEYLSTAPVLAVVAVIVAFCAWTIFNDIFPDLLF
                     HPMP"
     gene            1552..2736
                     /locus_tag="IQ233_RS20995"
                     /old_locus_tag="IQ233_20995"
     CDS             1552..2736
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042658.1"
                     /locus_tag="IQ233_RS20995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_20995"
                     /product="ABC-three component system protein"
                     /protein_id="WP_194002768.1"
                     /transl_table=11
                     /translation="MSTGFSAGPQALGYMFQARYALYLILTNKEELQSAVESLDDITFF
                     ENENNPIELLQLKHHTNAKASLTDNSSDLWKTIRVWSTQLQENKISLPDTLLTLVTTAK
                     ASANSATFLLRPFKDRDSKLAWEKLLEVANKSKNEDLTKSFKSFKALSTTQQQLLIDSI
                     QIIDGSSDIIDITPAIKEKLVAVRRKHRDAVYERLEGWWFAKVVKHLRDDSLDFISGFE
                     VRDKICEINDQFKPDALPIDFYDLKIPEQPDISQDNRCFVNQLKEIAIHNKRIENAILD
                     YYRAFEQRSRWAREELLFGGEIEKYERKLIDEWERYKLALQDEMSDGNDDESEYQKFGR
                     KVFNWMEQDANICIRDQVTEPYVMRGSYHILADKLLVHWHPKFLERLTQLLVTT"
     gene            2748..3248
                     /locus_tag="IQ233_RS21000"
                     /old_locus_tag="IQ233_21000"
     CDS             2748..3248
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039805.2"
                     /locus_tag="IQ233_RS21000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21000"
                     /product="three component ABC system middle component"
                     /protein_id="WP_194002770.1"
                     /transl_table=11
                     /translation="MQSWEQRPFEYANLLNPAFCSILLRNAIKSYHTQKKQGMPYPLLF
                     LVLPLVLHGSTRNALPKTTVTKLHIWLQRQPEARVGFGDRTSSLVPYTKEALAFGMQTG
                     IVNICDDGNFTYVNAKLKRILAVSWSKDTEPYSCCKKAEFVGRWLAQAGEVSTIYTMWG
                     ICP"
     gene            3260..5218
                     /locus_tag="IQ233_RS21005"
                     /old_locus_tag="IQ233_21005"
     CDS             3260..5218
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023946.3"
                     /locus_tag="IQ233_RS21005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21005"
                     /product="DUF3732 domain-containing protein"
                     /protein_id="WP_194002772.1"
                     /transl_table=11
                     /translation="MQIKSITLYNSAGDKRTIDFKLGQVNIITGDSSRGKSALLEIVDY
                     CLGRTESQIPYGVIQDKVAWYAVLFQINENQVFIAKPKPLENSASQNQVYYDFGTNILI
                     PELAHLEPNSNDDAIKSYLSQLIGISPNQTIVEEGGSRQKFETNIRHAIYYLFQKQSTI
                     ANQGILFHRQQENYIPQTIKDTIPYFLGAIQEDRLKLQKELHQARQRLAKALSSLKEAE
                     SITKKRVVIGGNLLIEAQQVGLINSNFIAKDASDILDALQSTLEWKATEVILTGNDQFP
                     ELQAEVEEIRQEFKQIHEKIIATETFLKKETGFSKEANQQLLRLESIDLFKKDNSNPHQ
                     CPFCNSILPESIPSLSAMKESLINLQNNVKNVEVSQPRLIEHIQQLKEQREELRLQIQE
                     KEMAINAAIDEQEAAQQIRDTNAHIARIVGRISLYIETLEFTDENSQIRSDIEQLRKLI
                     ASYEEQLDVGEIKAILASILNRIGQQMTEWAKRLKLEHSDSPYRFDLNNLTVIADRPDR
                     PIPMKRMGGGENWLGCHLITLLALHKHFVERNRPVPHFLFLDQPTQIYFPSEGGYLNLQ
                     KIPSDGNISSSADMEAVERMFDFLFDVCEELSPHFQIIIMEHANLANNERFQNSLVEKP
                     WTDGKALIPENWVSSQD"
     gene            5474..5647
                     /locus_tag="IQ233_RS21010"
                     /old_locus_tag="IQ233_21010"
     CDS             5474..5647
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IQ233_RS21010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IQ233_21010"
                     /product="hypothetical protein"
                     /protein_id="WP_227789169.1"
                     /transl_table=11
                     /translation="MSGWRGSRFSLKTRDGLNLSVEYSNHIWQCDHTRADILLVDQQGE
                     LLGRPWRTSIQL"
     gene            6013..7413
                     /gene="mgtE"
                     /locus_tag="IQ233_RS21015"
                     /old_locus_tag="IQ233_21015"
     CDS             6013..7413
                     /GO_function="GO:0015095 - magnesium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015693 - magnesium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mgtE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015115761.1"
                     /locus_tag="IQ233_RS21015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21015"
                     /product="magnesium transporter"
                     /protein_id="WP_194002774.1"
                     /transl_table=11
                     /translation="MTETNNLNFTTQNATRNELRDLVRNQLKILLEAGNLLEAKSILQP
                     VQPADIAEAIEGLPEAMHALVFRLLPKTQAIEVYEYLDYSVQEHLIEELKSQDVRDIVD
                     KMSPDDRARLFDELPAKVVNRLLEQLSPAERQATAQLLGYEAGTAGRIMTPELIYLKEN
                     FTVTQAIERIRSLANVSEMIYYLYVTDTARRLTGIVSLRELVVSQPEQTIGEIMTREVV
                     FVHTDADQEEVARLIQRYDFLAVPVVDKEQLLVGIVTVDDVIDILQQETTEDIYALGGG
                     VQSDGDNYFQMSLLQVARKRVVWLFVLLITNTVTGTIIKSQEDILKQAVILTAFIPLLT
                     GTGGNVGAQSSTVVIRGMSTDEIRSLKIWQIIGREAIAGAFLGIMLGSIATVWAYFLQG
                     RAEVAFTVGISLVAISIIASVSGSALPFLFRAVRLDPALMSAPFITTAVDVLGVVIYFK
                     LARVILGL"
     gene            complement(7476..7733)
                     /locus_tag="IQ233_RS21020"
                     /old_locus_tag="IQ233_21020"
     CDS             complement(7476..7733)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010999307.1"
                     /locus_tag="IQ233_RS21020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21020"
                     /product="hypothetical protein"
                     /protein_id="WP_194002777.1"
                     /transl_table=11
                     /translation="MTSPKPLIGTELVDCARANAKQGIETAAHQCGYGDDINRFARELR
                     DSCEKMNLQVKELNELITDQDMILELGTGEIVAPETASEL"
     gene            complement(7915..8769)
                     /locus_tag="IQ233_RS21025"
                     /old_locus_tag="IQ233_21025"
     CDS             complement(7915..8769)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (41-203). E-value: 2.2e-12.
                     Score: 39.2. Matches aSDomain:
                     nrpspksdomains_IQ233_RS21025_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017310770.1"
                     /locus_tag="IQ233_RS21025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21025"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_194002779.1"
                     /sec_met_domain="adh_short (E-value: 2.3e-36, bitscore:
                     118.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.9e-35, bitscore:
                     115.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEEILQPPQEQKPPGKESEMQPKPKADDPQYRGSGKLDNKVALI
                     TGGDSGIGRAVAIAFAKEGADVAIVYLKEHDDAKETKHLVENLGRRVVAIAGDITDETF
                     CQQAVEQTVEELGQLDILINNAAEQHPKENIEEITKEQLERTFRTNIFSMFYLTKAAMK
                     HLKSGSSIINTTSVTAYKGNAKLLDYSSTKGAIVAFTRSLSQNLVSKGIRVNAVAPGPI
                     WTPLIPSTFPADQVATFGKQVPMQRAGQPEEVAPSYVFLASDDASYMSGQVLHPNGGSI
                     VNG"
     aSDomain        complement(8161..8646)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IQ233_RS21025_PKS_KR.1"
                     /evalue="2.20E-12"
                     /label="IQ233_RS21025_PKS_KR.1"
                     /locus_tag="IQ233_RS21025"
                     /protein_end="203"
                     /protein_start="41"
                     /score="39.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGGDSGIGRAVAIAFAKEGADVAIVYLKEHDDAKETKHLVE
                     NLGRRVVAIAGDITDETFCQQAVEQTVEELGQLDILINNAAEQHPKENIEEITKEQLER
                     TFRTNIFSMFYLTKAAMKHLKSGSSIINTTSVTAYKGNAKLLDYSSTKGAIVAFTRSL"
     CDS_motif       complement(8575..8640)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IQ233_RS21025_0001"
                     /evalue="4.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IQ233_RS21025"
                     /protein_end="65"
                     /protein_start="43"
                     /score="12.8"
                     /tool="antismash"
                     /translation="LITGGDSGIGRAVAIAFAKEGA"
     gene            9184..9846
                     /locus_tag="IQ233_RS21030"
                     /old_locus_tag="IQ233_21030"
     CDS             9184..9846
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006198196.1"
                     /locus_tag="IQ233_RS21030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21030"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_194002781.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 1.1e-79,
                     bitscore: 259.1, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANQTLGIEPQLYNYLLSVSLREPKILSQLREETAQHPMAMMQIA
                     PEQGQFMALLVQLMGAKKTLEVGVFTGYSSLAVALVLPPEGRVVACDVSAEFTAIARRY
                     WQAAGVADKIDLHIAPAMETLDQLLAAGEAETFDFAFIDADKSNYDGYYERSLQLVRPG
                     GLIVIDNVLWSGKVADTEVQDNRTTKIRALNEKLHQDQRINLSLVPIADGLTLAHKK"
     gene            10001..10450
                     /locus_tag="IQ233_RS21035"
                     /old_locus_tag="IQ233_21035"
     CDS             10001..10450
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129602.1"
                     /locus_tag="IQ233_RS21035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21035"
                     /product="PqqD family protein"
                     /protein_id="WP_194002783.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.1e-18,
                     bitscore: 57.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-14, bitscore: 46.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENSQVFRVNSPQVVCETIDGEVVVVDLERGYYYSLLKTGADLWS
                     CIERHLQRHDIIQELGQKYDGTIGEITEAIDEFLDNLQHEGLIVADATITPGAINDQES
                     VTSTEKPKFEKPILEKFTDMEDLLLLDPIHEVDVDAGWPNVKTVS"
     misc_feature    complement(10020..10039)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 21.83"
                     /tool="antismash"
     aSDomain        10028..10270
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IQ233_RS21035_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.50E-18"
                     /identifier="RREFam002.1"
                     /label="IQ233_RS21035"
                     /locus_tag="IQ233_RS21035"
                     /protein_end="90"
                     /protein_start="9"
                     /score="57.6"
                     /tool="antismash"
                     /translation="NSPQVVCETIDGEVVVVDLERGYYYSLLKTGADLWSCIERHLQRH
                     DIIQELGQKYDGTIGEITEAIDEFLDNLQHEGLIVA"
     gene            10475..11485
                     /locus_tag="IQ233_RS21040"
                     /old_locus_tag="IQ233_21040"
     CDS             10475..11485
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129601.1"
                     /locus_tag="IQ233_RS21040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21040"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_194002785.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.2e-14, bitscore:
                     47.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDWSNRLAYFDSYRLKLSHKQLLKATLLKEQAMLTAWQDWRDS
                     VDIETLDSSSYLLLPQLYQNLLAHGVDDADMARLKGIYRRHWYANQLQLKSLTAILSSL
                     KDIGIEAIVLGDATWGGIGKNQIENYRPISSFHLLLDGNCLDTAIEHLLSLNWHSVDGS
                     KQQFKELRHNCDSSLNLRLYLQEHLFWAIPQDYTDGQVWHYATADWSSEAGWRLSATDQ
                     FLDGCARMFFRQRTKSSNPQIHRIADAFLLIANLPNNDWIRLITQAQRYQMILPVRNML
                     QLLQQLVSVELPSWVLPALWQMPIANTEWVKYRVLDGDRRSMIRSMIVQSLELLK"
     gene            11482..12579
                     /locus_tag="IQ233_RS21045"
                     /old_locus_tag="IQ233_21045"
     CDS             11482..12579
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129600.1"
                     /locus_tag="IQ233_RS21045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21045"
                     /product="serine kinase"
                     /protein_id="WP_194002787.1"
                     /transl_table=11
                     /translation="MNLHPNLSIAESDRLAYFQLVYTGFERAAQISTEVQYFYAIGKYN
                     ICLRFAGEGLIPQITPALSHLSIAPVPQPDLTICLWDNVSTKTQLPLLIDSLLTLIRRH
                     WADYLGPRKEIKAYDGDRIRSNFHIGPNILSVLDREQNLACYWIDNAEDIPYWEKGSPL
                     QTILNWWTSDHRQHQYVHAGAIGNPDGGVLLAGKGGSGKSSTALTCINSSLLYASDDYC
                     LVTSDPQPYVYSLYNTSKLKGQADLERFPHLADLVDNRDRLENEKAMLFLHQHHPQKIV
                     QGFPIKAVLVPQITGKLDTHLRPISAGAALRALAPSTIFQLAGSGQTALQIMSSLVKQV
                     PCYVLELGTDVTQIPNVILDLLSQL"
     gene            12600..13631
                     /locus_tag="IQ233_RS21050"
                     /old_locus_tag="IQ233_21050"
     CDS             12600..13631
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IQ233_RS21050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IQ233_21050"
                     /product="hypothetical protein"
                     /protein_id="WP_194002789.1"
                     /transl_table=11
                     /translation="MKKVVKSLIKKGFNYLIFERFSAKLSQLKPSPSLYEEIFKTKPLI
                     MTQQCNVELHMLVCKKDFLRSFWSLKSFFYYSGLSPRLVIQNDGSLTSEMIELYKEHFP
                     HCIVNTNNDDQIRDALTGYPMCQFFVGHHVMSKKLLHPLLLSQSEYILTMDSDILWFKQ
                     SKVITKCVQNILPFYVYGGSGAYVRNQKFMEAQLGLYPANNVNAGIVGYQKSKFLDLEF
                     IESAIHKLVDIPKDLILESVGYVDESVNINSEDINQTLCWWVMEQTIYALLLGRESQRQ
                     ALKCWSNKPLDLLFADLHQFTNSPIMRGTALIHYISDARHNQFFPAGVQHLIKRGFLAE
                     ISK"
     gene            13635..14327
                     /locus_tag="IQ233_RS21055"
                     /old_locus_tag="IQ233_21055"
     CDS             13635..14327
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017655073.1"
                     /locus_tag="IQ233_RS21055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21055"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_194002791.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.3e-40,
                     bitscore: 130.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHSPLVTVIIPLYNYANYIAATLDSVFAQTYRPIEVIVVDDGST
                     DNSAEIVRGYPEVQYFYQSNQGVSVARNVAIASAQGEFIAFLDADDLWKPDKLSLQIAY
                     MLENPDIGITGTKAINFLDSNTQLPPWLRDDPSWEEVKLIIPSTMVVHKSVFSQVGDFS
                     VDYPVSQDTEWLWRAKDAKIPMFNINEILTLRRFHGSNLSWLMAGSYKSEMLKMIKQSI
                     ARQSRQPQ"
     gene            complement(14329..15033)
                     /locus_tag="IQ233_RS21060"
                     /old_locus_tag="IQ233_21060"
     CDS             complement(14329..15033)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017655072.1"
                     /locus_tag="IQ233_RS21060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21060"
                     /product="glycosyltransferase"
                     /protein_id="WP_194002793.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-31,
                     bitscore: 102.6, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPLVSAIIAVQNGEKYLAQAIDSIVGQTYPKVEILVIDGKSTD
                     CTAAIAKSYPQVLYLRQTGKGLADAWNTGLNAAKGEIIAFLDHDDYCTSNKLALQVDYL
                     IQHPEVQAAIAHACFILADPTQPIPTGFKSKLLQKEQVARIPGTLVVYKTVFDLIGQFD
                     PNLTIASDVDWFARAKDQNISMFVIPEVLLYKRVHNNNLSANAFINNQEILGVLRKSIK
                     RQRTNQGMDKIH"
     gene            complement(15066..15827)
                     /locus_tag="IQ233_RS21065"
                     /old_locus_tag="IQ233_21065"
     CDS             complement(15066..15827)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (66-181). E-value:
                     2.7e-14. Score: 44.8. Matches aSDomain:
                     nrpspksdomains_IQ233_RS21065_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017655071.1"
                     /locus_tag="IQ233_RS21065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21065"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_194002795.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.3e-13, bitscore:
                     43.3, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.5e-07,
                     bitscore: 22.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.3e-14, bitscore:
                     44.8, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDFLRTRESTTKKLILLTGAAGNIGTSLQHELNGDYQFRCIDRR
                     HVPQAKDFRRVDITNFKAVLKVMGGVDAVIHLAANPNVDQPWQDVYSSGIGGTYNIFEA
                     ARQSGIKKIIYASTNYVSGWREVEQESHITPEQLVRPDSLYAVGKAFGEALGQYFSDRY
                     GMSVICLRIGWFHTEPKIYAPNDRILSNWCSSRDLAQIVRRSLEHDNLGFQIFYAVSGN
                     TRRYWDISNAQKLLGYEPEDNAEIYFRSFLS"
     aSDomain        complement(15285..15629)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IQ233_RS21065_NAD_binding_4.1"
                     /evalue="2.70E-14"
                     /label="IQ233_RS21065_NAD_binding_4.1"
                     /locus_tag="IQ233_RS21065"
                     /protein_end="181"
                     /protein_start="66"
                     /score="44.8"
                     /tool="antismash"
                     /translation="VMGGVDAVIHLAANPNVDQPWQDVYSSGIGGTYNIFEAARQSGIK
                     KIIYASTNYVSGWREVEQESHITPEQLVRPDSLYAVGKAFGEALGQYFSDRYGMSVICL
                     RIGWFHTEPKI"
     gene            complement(15846..16547)
                     /locus_tag="IQ233_RS21070"
                     /old_locus_tag="IQ233_21070"
     CDS             complement(15846..16547)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129596.1"
                     /locus_tag="IQ233_RS21070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21070"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_194002797.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.3e-41,
                     bitscore: 132.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPLVSVIIPCYNRERYLAEAIESVLEQTYPNIELIVIDDGSSD
                     RSGEIAQSYPLKYHYQTNGGIGAARNAGIAVANGEFLAFLDSDDIWVKDKLAKQMAVFD
                     THPDIEAVFGYAQNFYSPELDENFKSRIRCPEKPIAAHLSTAMLIKRSPFLRVGKFDTN
                     LKTGIDISWYIWAMEHQLQQITIPDVVYYRRLHESNNGITARQYANERLHLIKAKLDRE
                     RAKQRVLNKES"
     gene            complement(16547..17968)
                     /locus_tag="IQ233_RS21075"
                     /old_locus_tag="IQ233_21075"
     CDS             complement(16547..17968)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017655067.1"
                     /locus_tag="IQ233_RS21075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21075"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_194002799.1"
                     /transl_table=11
                     /translation="MNLEINKNNNQDNPAFTQFKLGNAWQLRGDLENASARYQETLILQ
                     PDFLPAYQQLGNLMLKQRRTAEAMDYYDQALAIDFDATDLSFYYQCLGWRKPSNYTQII
                     PDKKAENLYFSTKKTPSIATGKINLGQQRVFAPHRSGWNFAIQALSSLHNPQGVLFDGF
                     LENQFLFQHHHFGRRSPRILAKMRADEVFDSLADSEEKGIVPYKTPWVGFMHNPHRMPI
                     WFHYHRSPQKLFEKQIWQDSLPHCVGLFALSHYYGDWLRKETGKPVSVLIHPTEIPEKQ
                     FDFNQFIANPQKKVVQIGWWLRKLHSIYQLPLAKGNSLGYEKVRLGFLFESSEKILDQL
                     MKIEGRIYKIQVDPAYVENTTVIEHIPDDAYDDLLSMNIAFVDLYDSGVNNAIIECIAR
                     ATPILVNPIPAVKEYLGEEYPMYFHTLEEAAEKALDTALIWETHQYLKSCETRQKLSAD
                     YFLNSFCTSEVYKSI"
     gene            complement(17940..19283)
                     /locus_tag="IQ233_RS21080"
                     /old_locus_tag="IQ233_21080"
     CDS             complement(17940..19283)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129593.1"
                     /locus_tag="IQ233_RS21080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_21080"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_194002801.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1e-64, bitscore:
                     211.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKIISETPKNSLSPEVIALLACLKFHFHTTTVNEVRDLLRDDLN
                     WSKLIEISIAQGVMPLLYQSLKEIDDVPRSVMMQLQTLNRMNGLNNLSQTKELLRILTQ
                     LEKSGIEAIAFKGAVLAASAYGNVTLRQFNDLDILVRRRDFWQAKAVLMSQGYESNFSE
                     EAEIDGFETNLQISMSYKASEAEMFNARFEPSLLHSNPKRSIDLHWGIPPRRTWNPNHY
                     DRLWEYCQPMTLMGQSIKSFIPEIALIIQSVNIAKDYGWLRSLKQICDLAQVIQAYPDL
                     DWHLTLRLSSELRCEKLFLLGIYITQNLFNISVPDHIVSKFIQIKSLDTQIALFNSLES
                     KTDSTLHQALYESRLISAFRNLYLVYISPLKTLDSSLNPWGLDQRLSMSLLYLYFLIRR
                     LCVPNERDRQFLRLPQQLFFLYYFVRPIRVLWEYVLPKLYESGNKQKQ"
     misc_feature    complement(19596..19609)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.88"
                     /tool="antismash"
ORIGIN
        1 gcactagcag cagaatcacc cgtttcatga agcacaataa ttgctggatt gttcagaggt
       61 aagccattaa cgtcttgaga atatcgctct ccataattgc tggggtgtac tgaggcgatt
      121 tcatatcggg gtgtgtactg agcgaaagct gctgtagttt tgtatctccc cgcactctta
      181 ttagttgtaa ctgaagcagg aggtaaatct tctggtgatt catcctctgg actgtttgct
      241 gattgcaatt cggactgtgg atattgattc cagtctgtag tgatatcggc aatttcggaa
      301 ttataactta ttttattact ttgtattctt cccagtgaca aaactatcat tagtgtggtc
      361 aacatcaggg aaatcaataa tactctagta gcccaatctc taaactgcat tttgataata
      421 gttataaaac cagtcaattt aatctttcat attctaattt aactcaaaat aatttatgat
      481 tgctaagtta gcttttaggt attttttcta tcgaatggaa tatataaata ggactaaata
      541 taaaaatcat gaatattact tcagctagat ttatcgggga tatatttttt tgagaatata
      601 agcatttagt taaaaggata aaaaataatt ttatggcgca accaaataaa gaaaaagcct
      661 attttattga gtatctttcc accgcacctg tgcttgcagt tgttgcggtt atagttgctt
      721 tctgcgcttg gacgattttt aatgacattt ttcctgatct tctctttcat cccatgccat
      781 aattccaatt ctgtatgagt atgtgcggag ttatggaacg tagagcgaag ggcttccgca
      841 ggctacctca ttctcttacg agatgctacg cgaacgcgtt agcgtctccc aaggagaggg
      901 aaggaaatgg tgtgaggttc tgatgatggc gatcgctctt gcatcaatag ccccttgtgt
      961 ctaagctgat atggctattc ttcggtaatt ctaatgtagt tacaataggt taaagaaaaa
     1021 ttgaagtagg aacgctacag gcagatttaa ggctgtttat gccattagta atgagccaga
     1081 aagcagtatc aaccagaaat tagcaaattt tgctgcgaga ggtaaaataa gacaaataag
     1141 gaattttgag caacacaggg gatgcgatcg cgctaagttg agacttttgc gactataaag
     1201 ttatgaaact tcatacaggc tatatcttgt actacaaatc ttctatatac taaagattaa
     1261 ataagtcctg agtgtattta catctgatca acttgaccag aaaataagag tatgttattg
     1321 aatcatgaag atttgtagca tagtttttgg aaatatgcga ctataatctg taagccttga
     1381 tgaggcacta tcaaggataa atcaagctaa tatacccact ttatttatgt gtctgagtcc
     1441 tttaatcaac gttaactaac ataagttaga ttttaatgta taaaaaataa tacgtgaata
     1501 aataaaaggg ctttggctag taaactaact tagtcgaggt gattaaaagt tatgagtaca
     1561 gggttttcag caggtccgca agcacttgga tatatgttcc aagcgcgcta tgccctgtat
     1621 ttaattttaa ctaataaaga agaattacag agtgcagttg agagtttaga cgatattaca
     1681 ttctttgaaa acgaaaataa tcctatcgaa ttgttgcaat tgaagcatca tacaaatgct
     1741 aaagcttctt taacagacaa tagtagcgac ctttggaaga caattcgggt ctggagtacc
     1801 caactgcaag aaaacaaaat ttctttacct gataccttgc ttactctagt taccactgct
     1861 aaggcttctg caaattctgc tacatttttg ttacgtcctt ttaaggatag agactctaaa
     1921 cttgcatggg aaaagcttct tgaagttgct aataaatcaa agaatgaaga tttaactaaa
     1981 tcatttaaat catttaaagc tttaagtacc acacaacaac aactcctaat tgactcaatt
     2041 caaattattg atggctcttc agatattatt gatataacac cagcaattaa agaaaagttg
     2101 gttgcagtta gaagaaaaca ccgagatgct gtttatgaaa ggctagaagg ctggtggttt
     2161 gcgaaagttg taaagcatct tcgtgatgat tctcttgact tcatatctgg ttttgaagta
     2221 cgcgataaaa tttgcgagat taatgaccaa ttcaaaccgg atgctttgcc aattgatttt
     2281 tatgatttaa aaattcctga acaacctgat atttcacaag acaatagatg ttttgttaat
     2341 cagttaaagg aaattgctat tcataacaag cgaattgaaa acgccatctt agactactac
     2401 agagcatttg agcagcgttc tcggtgggcg cgtgaggaac tattgtttgg aggcgaaatt
     2461 gaaaaatatg agagaaagct aatagatgaa tgggagcgtt acaagctggc gcttcaagat
     2521 gagatgtcag atggtaatga tgatgagtct gaatatcaga aatttggtag aaaagtattt
     2581 aattggatgg agcaagatgc taacatttgc attcgtgatc aagttacaga accatacgta
     2641 atgcgtggta gctatcacat acttgcagat aaactcctcg tacattggca tccaaaattt
     2701 ctagaaagac taacccagtt attagttact acgtaggaga gaaatttgtg caatcttggg
     2761 agcagcgtcc atttgaatat gccaatcttc taaatccggc tttttgttca attctgctgc
     2821 gaaatgccat caaaagctat cacactcaaa agaagcaggg tatgccgtat cctcttcttt
     2881 ttctcgttct accgcttgtt cttcatggct caacgagaaa tgctttacca aaaacaacag
     2941 taactaagtt acatatttgg ctgcaaagac agcctgaagc tcgtgttgga tttggcgatc
     3001 gcacgagttc tttagtccca tatacaaaag aagctttagc ttttgggatg caaactggta
     3061 tcgttaatat ctgtgacgat ggaaacttta cttatgtaaa tgctaaatta aagcgtatct
     3121 tggctgtatc atggtctaaa gatacggaac catatagctg ctgcaagaaa gctgaatttg
     3181 ttggacgttg gcttgctcaa gccggagaag tatcaacaat ttatactatg tggggcattt
     3241 gtccgtaaag ttactctgta tgcaaattaa gtccataact ctctacaact ctgccgggga
     3301 taagcgaacc atagatttta aattaggaca agttaatata attactggcg attcgagtag
     3361 gggtaaatct gctcttcttg aaattgtaga ctattgcctg ggacggacag aatctcagat
     3421 tccttatggc gttatacaag ataaagttgc ttggtatgcc gttctttttc agattaatga
     3481 aaatcaggtt tttattgcaa aacccaagcc gctggaaaat agtgcttcac agaatcaagt
     3541 ctattatgat ttcggcacta atattctcat tcctgagtta gctcacttag aaccaaactc
     3601 taacgatgac gcaatcaaaa gttatttgtc ccaattaatt ggaatttctc ctaaccaaac
     3661 tattgttgaa gaaggagggt caagacaaaa atttgaaaca aatataagac acgcgattta
     3721 ttatcttttt caaaaacaaa gtactattgc aaatcagggt attttatttc atcgtcagca
     3781 agagaattat atcccacaaa caatcaaaga tacaattcca tattttttag gcgcaattca
     3841 agaagataga cttaaattgc aaaaagaact gcatcaagct cgtcagaggt tagcgaaagc
     3901 tctaagtagc cttaaagaag cagaatcgat tacaaaaaaa agagttgtta ttggtggtaa
     3961 tcttctgatt gaggctcaac aagtaggttt aataaattct aattttattg ctaaagatgc
     4021 gagtgatatt ttagatgcac tacagtctac tttggaatgg aaagcaactg aagttatact
     4081 gacaggcaat gatcaattcc cagaactaca ggctgaagtt gaggaaattc gccaagagtt
     4141 taaacaaata cacgaaaaaa ttattgctac agaaactttt ttaaaaaaag aaacagggtt
     4201 ttccaaagaa gccaatcaac aactattgag actagaatcg atagatttat ttaagaaaga
     4261 taatagtaat ccacatcagt gtcctttctg taactctatt ttgccagaat ctattcccag
     4321 cctttctgca atgaaagaat ctttgataaa tttacaaaat aatgtcaaaa acgtagaagt
     4381 tagccagcca agactaattg agcatattca acaacttaaa gaacagcgtg aagaactaag
     4441 actacaaatt caagaaaaag aaatggctat taatgctgcg atagatgagc aagaagcagc
     4501 ccaacaaatt cgtgatacta acgctcatat agctcgcata gtaggccgga ttagtctata
     4561 tattgaaact ttagaattta cagatgaaaa ttctcaaata cgctcagata ttgagcaatt
     4621 gaggaaactg attgctagtt acgaagaaca actagatgtt ggtgaaataa aagcaatttt
     4681 agcttccata ttaaatcgaa ttggacagca gatgacggaa tgggctaaac gactaaaact
     4741 tgaacatagt gactctcctt atcgatttga tttaaataac ttgactgtaa ttgcagacag
     4801 acctgatcga ccaattccta tgaaaagaat gggaggagga gaaaactggc tgggttgtca
     4861 cttaattaca cttctggctt tacacaaaca ttttgttgag cgtaatcgtc cagttccgca
     4921 ctttttattt ttagatcaac ctacccaaat ttattttcca tcagaaggag ggtatcttaa
     4981 tttacaaaaa ataccctcag acggaaacat tagttctagt gctgatatgg aagcagttga
     5041 aagaatgttt gactttttgt ttgatgtatg cgaagaacta tctccccatt ttcaaatcat
     5101 cattatggaa cacgcaaatc ttgctaacaa tgagaggttt caaaattcat tggttgaaaa
     5161 accttggact gatggtaaag ctttaatacc tgagaactgg gtatcatctc aagattaaac
     5221 gattacacac agattataga tggtattttt gggaacagtt gaactcaata acttcccagg
     5281 gggtaacggt ttaattcatc tttataaaat ttccaatctg gcagaaattt attcattaag
     5341 gagacgaagc gattgccaaa ttatttgacc acttgacaaa ttaatgtgca taaaaatatt
     5401 aactcctaaa ccctcactat ataagggttt tattatttta ggctatgttt agccaaacaa
     5461 gagcaaaaag ccagtgtctg gttggcgtgg ttctcgattt tcgctcaaaa cccgtgatgg
     5521 actgaattta tcagtggaat acagcaatca tatttggcag tgtgaccaca ctcgtgcaga
     5581 catattgcta gtagatcagc agggtgaact tttaggtcgt ccttggcgga caagtataca
     5641 attgtagaat atcttccatt tgacagacta ctaggtcgct ggaaacgtca gaaatctcaa
     5701 cttactgatg aggatgtaga aactccatct tcaacgaagt cagcaagtct gggagaaaaa
     5761 tttaatgtat atgaaggaat gtaaattatt cgtagagtgt gttgcgccgt aagtccaccg
     5821 caccttcttg caccttaatt tgttgacggt gctttacact gcgcgacaac actgactaca
     5881 gtttatttat ctttatatag ttatcaatat ttatgcccat ctacttaaga tgggggagtt
     5941 cattttctca ttcccacatt cccctaaact aaaagcagca aaccttttca aactggctga
     6001 ggaaagtaga ttttgacaga aacgaataat ttaaacttta ccacccaaaa tgccacgcgc
     6061 aacgaattgc gggatttagt gcgaaatcag ctaaaaattc tgctggaagc ggggaacttg
     6121 ctggaagcca aatctattct ccaacctgtg caaccagcgg acattgctga ggccattgaa
     6181 ggtttaccag aagcaatgca cgctttggtt tttcgcttgc ttcctaaaac tcaggctatc
     6241 gaggtgtatg aatatctcga ctacagtgtt caagaacatt taattgaaga actcaaaagt
     6301 caagatgttc gtgacattgt agataaaatg tccccggatg accgcgccag gttatttgac
     6361 gagttaccag caaaagttgt caatcgtttg ctagaacaac tgagtccagc agaacgccaa
     6421 gctacagccc aacttttggg ttacgaggcg ggtacagctg ggcgcatcat gacaccggag
     6481 ttaatttatc ttaaagaaaa ttttacagta actcaagcca tagagcgaat tcgcagcctc
     6541 gctaatgtca gtgagatgat ttactacctt tacgtgactg ataccgctag gcgtttgacg
     6601 ggaattgtat ctttacgcga gttggtggta tctcagcctg aacaaaccat tggcgaaatt
     6661 atgactcgtg aagtggtgtt tgtccacaca gatgcagacc aagaagaagt cgctcgatta
     6721 attcaaagat atgatttttt agctgttcct gtggtggata aagaacagct tttagtcggt
     6781 atcgtcaccg ttgatgatgt gattgatatt ctgcaacagg aaaccaccga ggatatctat
     6841 gctttgggtg gtggtgtgca gtcggatggt gacaactatt ttcagatgag tttactgcaa
     6901 gttgcccgca agcgggtggt gtggttattt gttttactga tcacgaacac agtgactggc
     6961 acaattatca agtcccaaga agatatttta aaacaagcgg tgatcctgac ggcgtttatt
     7021 cctttgctca caggtactgg tggtaatgtg ggcgctcagt cttctacagt ggtaattcgt
     7081 gggatgagta ccgatgaaat cagatcgctg aaaatatggc agataattgg cagagaagcg
     7141 atcgcggggg cgtttttggg aataatgtta ggtagcatcg ccacagtgtg ggcgtacttt
     7201 ttgcaaggac gcgccgaggt agcgttcact gtaggtatca gtctggtagc tatttctatt
     7261 attgcttctg tctcaggttc agcactgcca tttttattcc gcgctgtccg cttagaccca
     7321 gcgttgatgt cagcaccatt tattactaca gccgttgatg ttctgggtgt tgtgatttac
     7381 tttaaattgg cgcgagtcat tttaggttta taacttgtga gttatgatgc gtgagttaat
     7441 ttcatcaaaa ctccgcaatc ttcaccctaa aatttttata attccgaagc cgtctctggt
     7501 gcaacaattt ctccagtacc taattcgagg atcatatcct gatccgtaat taattcattg
     7561 agttccttca cttgtaaatt cattttttca caagagtctc tgagttcacg ggcaaaacgg
     7621 ttgatatcat cgccatagcc acattgatga gccgcagttt ctattccctg cttggcattt
     7681 gctctagcac aatctactaa ttctgtgcca atcaatggtt ttggagatgt cataattcgt
     7741 agttgtgatt tttcacttgt ttatcgttag ctagactagc atttatttac tattaatgta
     7801 tccatctgat ggcagagaaa tataaattgc taattgtaaa aatttccgat cccggtatct
     7861 tcaagatacc aggatggtca tctgttgcta aatcataact tctcacttgt tgaattagcc
     7921 gttgactatt gatccaccat tgggatgtaa tacttgacca gacatataag atgcatcatc
     7981 ggaagctaaa aagacataac tgggtgcaac ttcttctggt tgtccggctc gttgcattgg
     8041 aacttgtttg ccgaaggttg caacttgatc ggcgggaaag gtggaaggaa ttaatggtgt
     8101 ccaaattggg ccaggtgcga cagcattaac ccgaatgcct ttggagacta aattttgtga
     8161 taaggaacga gtaaaggcga ctattgcccc ttttgtagaa gagtaatcga gtaatttagc
     8221 attaccttta tacgctgtaa ctgatgtagt attaatgatg gaactacctg attttaaatg
     8281 tttcatcgct gctttagtca ggtaaaacat cgagaaaata ttagtgcgga aagtgcgctc
     8341 tagttgctct ttagtgattt cttcaatgtt ttcttttgga tgttgttcag ccgcgttatt
     8401 aatcagaata tcgagttgac ctaattcctc aacagtttgt tctacagctt gctgacaaaa
     8461 ggtttcatca gtaatatcgc cggcgatcgc cactacacgc cgccccagat tttctaccaa
     8521 atgtttggtt tctttcgcat catcatgttc cttcaagtaa acgatcgcca catctgcacc
     8581 ttctttggca aaggcgatcg ccacagcccg accaatacca ctatctcccc ctgtaatcaa
     8641 tgctacttta ttatctaact tgccactgcc tcgatactgg gggtcatcag ctttgggctt
     8701 gggctgcatt tctgattctt taccgggtgg tttttgttcc tgtggtggtt gtaaaatttc
     8761 ttctggcatc ggataatttc ctgtaaatta atgacggaaa aaacaattga taaaatccta
     8821 aaagtaaacc ctggatcgat aattcaatcc aaggttttat ttatgcttta actcccaact
     8881 tacaattgta agttcaggca tttttacccc ggatgtaagc caaacgtact aattgagggc
     8941 aattgcacgc gaccgacatt tttatcctca cacctgacac acgctcttaa tctgaccact
     9001 gaaaacaagt acacaactct cttagaatgt caggattttt cctgttcatc tgcttttaag
     9061 ttaactacga aattagggaa atttatcgtt cttgagatgg aaagacaaat tagcttttct
     9121 caaccttaag acgtaaaata aagtcataac aataaatcat ttgaatgtta attttactga
     9181 attatggcaa atcaaacact gggaatagaa ccacagctat ataactactt actctcagta
     9241 tctttacggg aaccaaaaat cctgtctcaa ctgagggaag aaacagccca gcatccgatg
     9301 gcgatgatgc agattgcacc ggaacagggg caatttatgg ctttgctagt gcaattaatg
     9361 ggagccaaaa aaactttaga agtaggggta tttacgggtt atagttcctt ggcggtggct
     9421 ttggtgttac ctccagaagg tcgggtagta gcctgtgatg tgagtgcaga atttacagcg
     9481 atcgctcgtc gttattggca agcagccggg gtagcggata aaatagactt acacattgct
     9541 ccagcaatgg agacattaga tcagttactc gccgcaggtg aagcagaaac ctttgatttc
     9601 gccttcatcg atgctgataa aagtaattat gatggttatt atgagcgatc gctacaatta
     9661 gtccgtcctg gtggattaat tgtgattgat aatgttctgt ggtcaggaaa agttgcagat
     9721 accgaagtcc aagacaatcg caccacaaag attcgcgccc tgaatgagaa actgcatcaa
     9781 gaccagcgaa ttaacctcag tttagttccc atcgccgatg gtttaaccct agcccacaag
     9841 aaataatttc tgtagaggta atacccttcg ggaagcctat ggctacatga attgcctcta
     9901 tagcaaaagt tgtgagcttt tagtataaaa aattactact aatggcatac cataaagcat
     9961 ggtattgtgt aaaattaata gtcaagttgt cagaacttat atggagaaca gccaagtgtt
    10021 tcgagtcaat agtcctcaag ttgtctgtga aactattgat ggagaagtgg tagttgttga
    10081 tcttgagcgg ggttactatt acagtctgct aaaaactggc gcagatttgt ggagttgtat
    10141 cgagcgtcat cttcagcgcc atgacataat ccaagaactt ggacaaaagt atgatgggac
    10201 tatcggagag attactgagg cgattgatga gtttcttgac aacttgcaac atgagggatt
    10261 aattgttgct gatgccacta ttacacctgg ggctattaat gatcaagaat cagttaccag
    10321 taccgaaaag cccaaatttg agaaaccgat actagagaag tttacagata tggaagattt
    10381 gctgctgctt gatccgattc atgaggtgga tgtagatgca ggatggccaa atgtgaagac
    10441 ggtttcatag tgaagacaat atgttgattt tactatgagt ttagactgga gcaatcgcct
    10501 ggcttacttt gatagttatc gattaaaatt gtcccacaaa caattactca aagccacact
    10561 cttaaaagag caggcaatgt taacggcttg gcaagattgg cgagattcag ttgatataga
    10621 aactttagat agtagttcct atttattgtt gccacaactt taccaaaatt tattagctca
    10681 tggagttgat gacgctgata tggctaggct caaggggatc tatcgccgcc attggtatgc
    10741 taatcaattg caactcaaat ccctgacagc aatattgtct agtttaaagg acattggcat
    10801 tgaggcgatt gtgctggggg atgcgacttg gggtgggata ggtaaaaatc aaatcgagaa
    10861 ttaccgccca atttctagct tccatctctt gcttgatggc aattgtttag acacagcaat
    10921 cgagcatttg ctctcgctaa attggcatag cgttgatggt agtaagcaac aatttaagga
    10981 attacgccac aattgtgatt catcgctgaa tttacggctt tatttgcaag aacatctgtt
    11041 ttgggcaatt ccccaagact atacggatgg gcaggtgtgg cattatgcaa ctgcggattg
    11101 gagcagtgaa gcgggttggc ggctgagtgc aacggatcag ttcctggatg gatgcgcgcg
    11161 aatgtttttt agacagcgga ctaaatcatc aaatccacag atacacagga ttgcagatgc
    11221 tttcctgtta attgcgaatc tcccaaacaa cgattggatt aggttgatta cacaggcaca
    11281 gcgatatcaa atgatcttgc ctgtgcggaa tatgttgcag cttttgcagc agttagtttc
    11341 agtagaatta ccaagttggg tattaccggc tctctggcaa atgccgatcg ccaatacgga
    11401 gtgggtaaaa tatcgagttt tagatggcga tcgccgttct atgattcgtt cgatgattgt
    11461 ccaatcctta gaattattga aatgaacctt caccctaatc tgagtattgc tgagagcgat
    11521 cgccttgctt atttccaact ggtatataca ggctttgaga gagctgctca gatttccaca
    11581 gaggtgcagt atttttatgc catcggtaag tataatatct gtctgagatt tgcgggagag
    11641 gggctgattc cccagattac ccctgcattg tcccatctct ctatagcccc agttccccag
    11701 cctgatctca cgatttgcct gtgggataat gtctcaacta aaacacaatt gccgttatta
    11761 attgatagtc tattaactct gattcgacgg cattgggcag attatctggg tccacgcaaa
    11821 gagatcaaag cctatgatgg cgatcgcatt cgcagcaatt ttcatattgg ccccaacatt
    11881 ctcagcgtgc tagatcgaga gcaaaattta gcttgttatt ggattgacaa tgctgaagat
    11941 attccttatt gggaaaaagg ttcacccctg caaaccatct tgaactggtg gacaagcgat
    12001 caccgccaac atcaatatgt tcacgcaggt gcgatcggca atccggatgg gggagttttg
    12061 ttagcaggaa aaggtggatc tggcaaatct tccacggcgc tcacctgtat caatagttcc
    12121 ctgctctatg ccagtgatga ttattgttta gtcaccagtg atcctcaacc ctatgtttat
    12181 agcctctaca acacctccaa attaaaagga caagcggatc tagaacgatt tccccattta
    12241 gccgatctag tggataatcg cgatcgctta gagaatgaaa aagcaatgct atttttgcat
    12301 caacaccatc ctcaaaaaat cgtacaagga tttcccatca aagccgtgct agtgcctcaa
    12361 atcacaggga aactagatac ccatctccgt cccatcagtg caggagcagc cttacgcgcc
    12421 ctagccccta gtaccatctt tcaattagct ggtagtggac aaacagcatt acaaatcatg
    12481 tcaagtttag tcaagcaagt tccttgctat gttttggaac ttggtactga tgtcacccaa
    12541 atcccaaatg tgattttgga tctactctca caactttaga gatcataaat tttcatctta
    12601 tgaaaaaagt cgttaaaagt ttaattaaaa aaggttttaa ttatttgatt tttgagagat
    12661 tttctgcaaa attatctcaa ctcaagccaa gcccatctct ctacgaagag atatttaaaa
    12721 ctaaaccttt gatcatgacg cagcagtgta atgttgaatt acatatgctg gtttgtaaaa
    12781 aggattttct ccgcagcttt tggtcactaa aatccttttt ctactattca ggtctatctc
    12841 caagattagt tattcaaaac gatggctctc tcacatctga aatgattgag ctatacaaag
    12901 aacactttcc acactgtata gtaaacacca ataatgatga tcagatccga gacgctctca
    12961 caggttatcc gatgtgtcag ttttttgtag ggcatcatgt gatgtccaaa aaactattgc
    13021 atcctttact cctttcccag agtgaatata ttctgactat ggattctgat attctctggt
    13081 tcaagcaatc caaagttatt acaaagtgtg tccaaaacat tttgccattc tatgtatatg
    13141 gtggttctgg agcctatgtc cgtaatcaaa aatttatgga agcccagcta ggactatatc
    13201 ctgctaataa cgttaatgca ggtattgtcg ggtatcaaaa atcaaaattt ttagacctgg
    13261 aatttataga atcagcaata cacaagttgg ttgatattcc caaagactta atactagaaa
    13321 gtgtcggcta cgttgatgaa tccgttaata taaactcaga agatatcaac caaacactat
    13381 gctggtgggt gatggagcaa actatttatg ctttgctatt ggggcgtgaa tcacagcgac
    13441 aagctctgaa atgttggtct aataaaccat tagatttact cttcgccgat cttcaccaat
    13501 ttaccaatag tccaattatg agagggacag ctttaattca ttatatttca gatgcaagac
    13561 acaatcaatt ttttccagca ggcgttcaac acctaatcaa acgcggtttt ttagcagaaa
    13621 tatccaaata agttatggaa cattcccctt tagttactgt cattatccct ctctataatt
    13681 acgccaatta tatagccgca acacttgaca gtgtatttgc tcaaacctat cgcccgattg
    13741 aagttattgt tgtggatgat ggttcaacag acaacagtgc ggaaattgtg cgtggttatc
    13801 cagaagtaca gtatttttat caatcaaatc aaggtgtgtc agttgctcgc aatgtggcga
    13861 tcgcatctgc tcagggtgag tttatcgcat ttttggacgc agatgatctc tggaaaccag
    13921 ataaactcag tcttcaaatt gcctatatgc tggaaaatcc tgatattggg atcacaggta
    13981 caaaggcgat aaatttctta gattcaaata ctcaacttcc gccttggctg agagatgatc
    14041 ccagttggga agaggtgaaa ctgatcattc ccagcacaat ggtggttcac aaatctgttt
    14101 ttagtcaagt tggagatttt tctgttgatt atcctgtcag ccaggataca gaatggctat
    14161 ggcgagccaa agatgcgaaa atccccatgt ttaatatcaa tgaaatcctg acattaagac
    14221 gatttcatgg ctctaattta tcatggctga tggcaggatc ttacaaatct gagatgttga
    14281 aaatgatcaa gcaatcgatc gctcgtcaat cgcgccaacc tcaataagct aatgtatttt
    14341 atccatgcct tgattagtcc tttgtctttt aattgatttt cttaaaacac ctaaaatttc
    14401 ctgattgttg ataaaggcat tggcagaaag gttattatta tgaacccttt tgtagagaag
    14461 aacttcaggt attacaaaca tagatatatt ttggtctttt gcccgtgcga accagtctac
    14521 atcgctggca attgttaaat ttggatcaaa ctgaccgatc aaatcaaaga ctgttttata
    14581 tactactaaa gtacctggga ttctggcaac ctgttctttt tggagcagtt ttgatttgaa
    14641 tccggtgggg ataggttgtg ttgggtcggc taagataaag caggcatgag cgatcgcagc
    14701 ctgcacttct ggatgttgaa ttaagtaatc tacctgtaat gctaacttgt tggaagtaca
    14761 gtagtcgtca tgatctaaaa aggcaattat ctctccttta gcagcattta gtccggtatt
    14821 ccaggcatca gctaaaccct taccagtctg gcgcaagtat aaaacttgag gatagctctt
    14881 agcgatcgct gctgtgcaat cggtagactt gccatcaatg actaatatct caacttttgg
    14941 gtaggtttga ccaacaatac tgtcgattgc ttgagctaaa tatttttcgc cgttttgaac
    15001 tgcaataata gcactaacca agggctgact cattattttc ctaaaagcaa agatatttcc
    15061 ttaatttagc tcagaaaact cctgaagtag atttccgcat tatcttcagg ttcgtatcct
    15121 aacagttttt gagcattgct gatgtcccaa tagcggcggg tgttgccaga aacagcataa
    15181 aaaatctgaa aaccaagatt gtcatgctct agcgatcgcc taactatttg tgctaaatct
    15241 ctagaactgc accagtttga taatatccga tcattgggag cataaatttt cggttcagtg
    15301 tgaaaccagc caatccgcaa acagatcacc gacatcccat agcgatcgct aaaatattgt
    15361 cctaaagctt caccaaatgc tttccccact gcatacagag aatcaggacg cacaagctgt
    15421 tcaggggtaa tgtgagattc ctgttccact tcccgccatc ctgaaacata attggtgctg
    15481 gcatagataa tttttttgat tcccgattga cgggcggctt caaatatgtt gtaagtccca
    15541 ccgataccac tactataaac atcttgccaa ggttggtcaa cattaggatt tgccgctaga
    15601 tgaattaccg cgtccacacc acccatgact ttaagaacag ctttaaagtt agtgatatcc
    15661 acacgacgga aatctttggc ttggggaacg tgacggcgat caatacagcg aaattgataa
    15721 tcaccattca gttcatgctg tagagatgtc ccaatgtttc cagcagcacc ggttaataaa
    15781 atcaatttct ttgttgtcga ttcacgggtt ctcagaaagt caaacatagt agtgctgtcg
    15841 cctcctcaag attctttgtt taaaactctc tgttttgcac gctctcgatc tagcttggct
    15901 ttgatcaggt gtagtcgttc atttgcgtat tgacgtgctg taattccatt attgctttca
    15961 tgtagccgcc ggtaatagac cacatctgga attgtaattt gttgaagttg atgttccatc
    16021 gcccagatat accaactaat atcaatacct gttttgagat tggtgtcaaa ctttcccact
    16081 ctcaagaaag gcgatctttt gattaacata gcagtagaaa gatgcgccgc aattggtttt
    16141 tctgggcagc gaatcctgct tttaaagttt tcatctagtt cgggactata aaaattttga
    16201 gcatagccaa agactgcttc tatatctgga tgagtatcaa agaccgccat ttgttttgct
    16261 agtttgtcct taacccaaat atcatcagaa tcgagaaagg cgagaaattc accattggct
    16321 actgcaattc cggcatttct agcagcaccg atccccccat tggtttgata gtgatatttc
    16381 aggggatagc tttgggcaat ttcgccactg cgatcgctcg atccatcatc gatcacaatc
    16441 aactcgatgt taggataggt ttgctctaaa acactttcga tagcttcagc taaatagcgc
    16501 tctcgattat agcagggaat aatgacgcta actaaaggta aattcatcag attgatttat
    16561 atacttcgct tgtacaaaag ctgttaagaa agtaatcagc cgaaagtttc tgtctggttt
    16621 cacaggactt aagatactga tgtgtctccc aaattaatgc cgtatccaat gctttttctg
    16681 ccgcctcttc tagagtatgg aaatacatcg gatattcttc acctagatat tctttgacag
    16741 caggaatagg attaactagt attggtgtag cacgggcaat gcattcgata attgcattat
    16801 ttacaccaga gtcatacaaa tccacaaagg cgatattcat cgacagcaga tcatcatagg
    16861 catcgtcggg aatatgttca ataacagttg tattctcaac ataagctgga tcaacttgaa
    16921 ttttataaat cctcccttca attttcatta gttgatctaa tattttttct gatgattcaa
    16981 acaaaaaacc taatctgact ttttcgtaac caagagagtt acctttagct agaggtaatt
    17041 gataaatcga atgtaatttc cgcaaccacc agccaatctg caccactttt ttctgaggat
    17101 tggcaataaa ttgattaaaa tcaaattgtt tttcgggaat ctccgtggga tggattaata
    17161 ccgaaactgg tttacctgtt tctttcctca gccaatcgcc ataatagtga gatagtgcaa
    17221 acaatcccac gcaatgaggc aaactatctt gccaaatttg cttctcaaat agtttttggg
    17281 gcgatctgtg ataatggaac cagatgggca tcctgtgggg gttgtgcata aatcccaccc
    17341 aaggagtttt ataaggtact ataccctttt cttctgagtc cgctaaacta tcgaaaactt
    17401 catcagcccg catttttgct aatatccggg gcgatcttct accaaagtga tgatgttgaa
    17461 aaagaaattg attttctaga aagccatcaa acaaaacacc ttggggattg tgtaaagaac
    17521 ttagcgcttg aattgcaaaa ttccaaccac tacgatgagg agcaaaaact ctttgttgtc
    17581 cgagattaat ttttcctgtg gctatacttg gtgttttttt agtagaaaaa taaagatttt
    17641 ctgctttttt atctggaata atttgtgtgt aattactagg ttttcgccag cccaaacatt
    17701 gataataaaa agaaagatca gtggcatcaa agtcaatagc taaagcttga tcatagtaat
    17761 ccatcgcttc tgctgtccgt cgttgcttga gcatcaaatt gcccaattgt tgataggcag
    17821 gcaaaaagtc tggttgcagt attaaggttt cctgataacg agcggaggca ttttccaagt
    17881 caccgcgcag ttgccaagca tttcctaatt taaattgggt gaaagctggg ttgtcttggt
    17941 tattgttttt gtttatttcc agattcatag agttttggca atacgtattc ccataatacg
    18001 cggatgggac gcacaaagta atacagaaaa aataattgct gaggaagtct taaaaattgg
    18061 cgatcgcgtt cattcggtac gcataatctc ctgatcagaa aatacaaata taataaactc
    18121 attgaaagtc tttgatcaag tccccaagga tttaatgaac tatctagggt ttttaatggt
    18181 gagatataca ctaaatacag attgcggaaa gccgatatta gtctactttc atataatgct
    18241 tggtgtaaag tgctatctgt cttactctct agagaattga acagtgcaat ttgtgtatcc
    18301 agggatttaa tctgaataaa ttttgataca atatgatctg gtacagaaat attgaagaga
    18361 ttttgagtta tatagattcc cagtaaaaat agtttctcac accgcaactc tgaagatagt
    18421 cgcaaagtta agtgccaatc taaatcagga tatgcttgga tcacttgggc aagatcacaa
    18481 atttgtttaa gcgatcgcaa ccatccataa tccttagcaa tattaacact ttgaataatt
    18541 aacgctattt ctggaatgaa acttttgata gattgaccca tcagtgtcat gggctgacaa
    18601 tattcccaaa ggcgatcgta atggttcggg ttccaagtcc gtctcggtgg aataccccaa
    18661 tgtaagtcaa tactacgttt tgggttacta tgcagcaatg atggctcaaa tctggcgtta
    18721 aacatctctg cttcagaggc tttgtaagac atagagattt gcaaatttgt ctcgaagcca
    18781 tcaatttcag cctcctctga gaaattagac tcatagcctt gactcattaa aactgctttg
    18841 gcttgccaaa agtcccgtcg ccgcaccaaa atatcaagat cattaaactg gcgcaacgtc
    18901 acattaccat aagctgatgc tgcaagtacc gctcccttaa aagcgatcgc ctcaattcct
    18961 gacttttcta attgcgtcaa aatccttaac agctctttcg tttgagataa attattcaat
    19021 ccattcatgc gattgagtgt ttgcagttgc atcattaccg agcgagggac atcatcaatt
    19081 tccttcagac tttgatacag cagaggcatt acaccctgag cgatgctaat ttctatcaat
    19141 ttagaccagt taagatcatc tcttagtaag tccctgactt cgttaacagt tgtcgtgtga
    19201 aaatggaact tgagacaagc aagtaaagcg attacttccg gagataaact atttttagga
    19261 gtttcagata ttatcttatc catgatttca ttacacaaaa aaagccgatt tcagaattat
    19321 gataaatctt gtggggtggg catcctgccc gcccttgcgt acctactcaa atcaaatgtg
    19381 ctgtattatc gataattttt agcttgggtt gtaaataaat cagcatattt accattgaga
    19441 gacatgagtt gatcgtgagt tccactttca acaatctcgc cctcatgcaa cacataaatt
    19501 cgatctgctg ttctcacagt agccagtcga tgggtaatta gcaaaactgc gcgatcgccc
    19561 atgatttctc gaaatttctg gaataccgcc gcctctgcat aagcatccat actactggtc
    19621 ggttcatcta atattactaa ctgagcatct cgcaaaaaag cacgcgccag ggcaattttc
    19681 tgccactgac caccactcaa ttgttctccg cccttaaacc atttacctaa caaagtttca
    19741 tattcttgcg gtaacttctt aataacagaa tcagcacctg aatattgaga tgcttccata
    19801 acttttggtg aatcaggtga taaatcaata ttaccgaccc agatattttc cttggctgtg
    19861 agttgatagc aggtatagtc ttgaaaaatt acactaatct gacgctgtaa atcattgata
    19921 gcaaagtctt taatattaac tccatcaata gtaatactac cgctagttac atcataaaga
    19981 cgacaaaaca atttcactag ggtagttttg ccagaaccat tttcaccaac cagtgccacc
    20041 acttctttag gggcaatttt cagattgact tgtttaattg ccttcctaga cgaattttga
    20101 tgttgaaagg tcacattctc aaaaacaata cccttttgca ttttagatgg aactggcttg
    20161 ggctgcatag tttcatacat cccatttggg agagatagaa aatcaaatat atccgacaga
    20221 aataaattat tttcatgcag tccgcctaga ctagcaatca attctttgag tccattttgt
    20281 cccctctgaa atgcttgact atataaaact aaatcaccca attgaaactt accgtaaatt
    20341 gtttgatgaa taataaatcc ataggttcct atcatcaaca gcccagtaca accctgtgca
    20401 attaatcgca ttagagattg tcggactgta atagcaagtt tctctttaaa
//
