LOCUS       NZ_JADEWH010000005     20933 bp    DNA     linear   CON 23-DEC-2023
DEFINITION  Nodularia sp. LEGE 06071 N071000005, whole genome shotgun sequence.
ACCESSION   NZ_JADEWH010000005
VERSION     NZ_JADEWH010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nodularia sp. LEGE 06071
  ORGANISM  Nodularia sp. LEGE 06071
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Aphanizomenonaceae; Nodularia.
REFERENCE   1  (bases 1 to 326858)
  AUTHORS   Castelo-Branco,R., Eusebio,N., Adriana,R., Vieira,A., Brugerolle De
            Fraissinette,N., Rezende De Castro,R., Schneider,M.P.,
            Vasconcelos,V. and Leao,P.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-2020) Cyanobacterial Natural Products, CIIMAR,
            Terminal de Cruzeiros do Porto de Leixoes, Matosinhos 4450-208,
            Portugal
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: SPAdes v. nov/18
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 30x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/23/2023 19:29:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,867
            CDSs (total)                      :: 4,805
            Genes (coding)                    :: 4,703
            CDSs (with protein)               :: 4,703
            Genes (RNA)                       :: 62
            rRNAs                             :: 6, 7, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 3, 3 (5S, 16S, 23S)
            partial rRNAs                     :: 4 (16S)
            tRNAs                             :: 42
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 102
            CDSs (without protein)            :: 102
            Pseudo Genes (ambiguous residues) :: 0 of 102
            Pseudo Genes (frameshifted)       :: 22 of 102
            Pseudo Genes (incomplete)         :: 84 of 102
            Pseudo Genes (internal stop)      :: 12 of 102
            Pseudo Genes (multiple problems)  :: 15 of 102
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:23:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 226795
            Orig. end                         :: 247728
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADEWH010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20933
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20933
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20933
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10933](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10933
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(207..1388)
                     /locus_tag="IQ233_RS11000"
                     /old_locus_tag="IQ233_11000"
     CDS             complement(207..1388)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010996912.1"
                     /locus_tag="IQ233_RS11000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11000"
                     /product="aldo/keto reductase"
                     /protein_id="WP_193998941.1"
                     /transl_table=11
                     /translation="MLYKRFGRTELQMPVFSCGGMRYQFKWQDVPNSEIPADNQANLEA
                     TIRRSLEVGINHIETARGYGTSEIQLGQILPKFPREKLIVQTKVGPVADSQKFRETFEQ
                     SLQNLQLDYVDLLGIHGINHAESFDYSMRDGGCLDVARQLQAEGKVRFIGFSTHGPKEV
                     IIQAINTNQFDYVNLHWYYINQWNWEAITAANSHDMGVFIISPSDKGGMLYKPPQKLVN
                     LCAPLSPMVFNDLFCLSHENVHTLSLGAARPEDFDEHLKTLDYLDRAEEFLPPILSKLE
                     QEAIATLGEDWVKTWETNLPTWEATPGEVNIRVILWLWNLAIAYDLVDYAKMRYNLLGN
                     ASHWFPGNKADQLDELDLGQSLANSPHAEKIPQMLAKAHEMLAGAEVKRLSKT"
     gene            complement(1554..2768)
                     /locus_tag="IQ233_RS11005"
                     /old_locus_tag="IQ233_11005"
     CDS             complement(1554..2768)
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006198224.1"
                     /locus_tag="IQ233_RS11005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11005"
                     /product="HhoA/HhoB/HtrA family serine endopeptidase"
                     /protein_id="WP_193998943.1"
                     /transl_table=11
                     /translation="MQFSQISSSIRQFAAYVLALIIGVTLTVSTWQVLPSQAEPAPDAE
                     TATAALDVIARQSPATAAIGSTSFVTAAVNRVGTAVVRIDTERTITRRMDPFMEDPFFR
                     RFFGEGFPQQLPSEQLRGLGSGFIIDKGGLVLTNAHVVDKADKVTVRLKDGRTYEGKVQ
                     GIDEVTDLAVVKINPDKDLPVAPLGSSDAVQVGDWAIAVGNPLGFDNTVTLGIVSTLKR
                     SSAQVGIADKRLDFIQTDAAINPGNSGGPLLNERGEVIGINTAIRPDAMGIGFAIPIDK
                     AKAIALQLQRDGKVIHPYLGVQMVTLTPELAKQNNTDPNSPIQIPEINGVLVMRVIPNS
                     PAANAGVRRGDVIVQIDREPVTSADKLQNLVDNSRLGQLLNVKVQRGNQIQLLSVRTAE
                     LQDPV"
     gene            3059..3457
                     /locus_tag="IQ233_RS11010"
                     /old_locus_tag="IQ233_11010"
     CDS             3059..3457
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006198225.1"
                     /locus_tag="IQ233_RS11010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11010"
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="WP_193998945.1"
                     /transl_table=11
                     /translation="MNGSNRLAKKSVPASQAGENAQNHHVEDQKNHPHEPGKSVHPHVH
                     SEESLRKIVNRLSRIEGHVRGIKTMVQHDSPCPDVLLQIAAVRGALDKVARIVLDQHLT
                     ECIARAAQEGNMEVEIEQLKAALDRFLP"
     gene            complement(3454..4557)
                     /gene="nagZ"
                     /locus_tag="IQ233_RS11015"
                     /old_locus_tag="IQ233_11015"
     CDS             complement(3454..4557)
                     /EC_number="3.2.1.52"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nagZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129830.1"
                     /locus_tag="IQ233_RS11015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11015"
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="WP_193998947.1"
                     /transl_table=11
                     /translation="MAVSQELERFGHHLILGISGTSLSDDDKRTLSELKPVGVIYFAKN
                     FLDATPYEVWLESFQKLNEQIREYTERDSMFMTLDHEGGRVVRTPLPITRFPYALLWKS
                     HAREVAKATALELKSLGINLSWSPVADIFSHPQNPIIGPRAFGRNPETTAEGVCEYYRG
                     LEEGGILGCAKHFPGHGDTSKDSHLELPVLNLTLEELRLRELIPFKALIEKQIPLIMTA
                     HILFPKIDPQFPATLSPAILKKILREELGFAGVVVSDDLDMKAVSDMFTESGTVAQAFD
                     AGCDLFIVSRNINSLSIERTYQMAEDFADSLSRGSLDESVVAAARDRIENLLAVTPQHK
                     IYALDKNILQQHAELAIACCFEGSGEF"
     gene            complement(5218..6069)
                     /locus_tag="IQ233_RS11020"
                     /old_locus_tag="IQ233_11020"
     CDS             complement(5218..6069)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006198227.1"
                     /locus_tag="IQ233_RS11020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11020"
                     /product="2OG-Fe(II) oxygenase"
                     /protein_id="WP_193998949.1"
                     /transl_table=11
                     /translation="MLTKTSKSYYTEQILNKLEQSKSALKKQFMIENRINTCYLDDLLN
                     EEDVLKIYHAFPDKKNLLQLKDLREHKYVGIQLDKYDPLLEEIIYAFQDTRIVNLIAEI
                     TGLEQLMPDEYLYAGGVSLMDYGCFLNPHLDNSHDKDISNYRVLNLLYYVTPNWQENYG
                     GNLELWDQDLKQPCRTIHSKFNRLVIMVTNKTSWHSVSPINYHGQRCCVSNYYFSPKPA
                     DVHKYYHVTSFRGRPEQNLRDIVLRGDASLRNMVRKIFKHGIKKPHFYKNRVLNNTINK
                     CG"
     misc_feature    complement(6117..6131)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.22"
                     /tool="antismash"
     gene            6361..7254
                     /locus_tag="IQ233_RS11025"
                     /old_locus_tag="IQ233_11025"
     CDS             6361..7254
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006198228.1"
                     /locus_tag="IQ233_RS11025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11025"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_193998951.1"
                     /transl_table=11
                     /translation="MLKEVDTNCSQYFAQPNKIDGWDEDIIICPILNPTPAIQANSYYF
                     GHPEWGLNYFQACHRNEKFVELWQAVIGSWQDKVVVDIGCGPGNVYASLKEFCGEPQLL
                     LGVDVSLGALKMARQLGYTAVLADAQNLPFVSGFADIVMLNASLHHCDDMPKVLQEAAK
                     LVRPGGLLITDHDPQKSAYQFKGLGSLLWKIRLPIYKYIKRGGHSSSEEQFWGLATEVH
                     HKAFDGVTSEMFDQVLEPMGFRVKVYPHNHTVGAEALKGNYGKPFWKYRLAQRLSGIDP
                     NSLEAALSLMCVATRY"
     gene            complement(7281..8054)
                     /locus_tag="IQ233_RS11030"
                     /old_locus_tag="IQ233_11030"
     CDS             complement(7281..8054)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017744120.1"
                     /locus_tag="IQ233_RS11030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11030"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_193998953.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4e-21, bitscore:
                     69.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEHITPLILTYNEAANIRRTLEHLTWAKKIIVIDSYSTDTTLEI
                     LHSYSQVQVFKREFDTHGKQWNYGLEQVKSPWVLSLDADYIVTDDLISEIAALPMDGEI
                     DGYFVRFKYCVFGKPVRNTRILPPRQVLFQKSKAIYIDDGHTQVLQLTGKSDVLSAYLY
                     HDDRKPFSRWLWSQERYTVLEAKKILETPINELDWVDRIRRKKILAPGMVFLYCLIIEG
                     WIFDGWHGWYYVFHRVLAETILAIRIIEAEKLKRQ"
     gene            complement(8377..8523)
                     /locus_tag="IQ233_RS11035"
                     /old_locus_tag="IQ233_11035"
     CDS             complement(8377..8523)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IQ233_RS11035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IQ233_11035"
                     /product="hypothetical protein"
                     /protein_id="WP_193998955.1"
                     /transl_table=11
                     /translation="MQSVTFGRGCAIASPKTSGKGNFTEIHQPQQSASIITTQALNDSF
                     VSY"
     misc_feature    complement(8548..8557)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            8578..10017
                     /gene="pds"
                     /locus_tag="IQ233_RS11040"
                     /old_locus_tag="IQ233_11040"
     CDS             8578..10017
                     /EC_number="1.3.5.5"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pds"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015114894.1"
                     /locus_tag="IQ233_RS11040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11040"
                     /product="15-cis-phytoene desaturase"
                     /protein_id="WP_193998957.1"
                     /transl_table=11
                     /translation="MRVAIAGAGLAGLSCAKYLTDAGHTPIVLESRDVLGGLVAAWKDS
                     DGDWYETGLHAFFGAYPNMLQLLKELGIEDRLQWKEHTLIFNQPEKPGTLSRFDVPDIP
                     SPFNVIASILRNKDMLTWEQKIRFAIGLLPAVVRGQQYVEDMDKYSFLEWLERQGVGER
                     VTSDVFIAACKALTFINPEEVSATILLTALNRFLQERYGSKIAFLDGSPTERLCQPMVD
                     YITERGGEVRLNSPLKQILLHPDGTVKGFLLRGLNGAEDQVLTADMYVSAMSVDPLKVM
                     LPEPWQQMEYFQKLEGLEGVPVINVHLWFDRKLTEIDHLLFSRSPLLSVYADMSNACRE
                     YANSERSMLELVLAPAKDWITKSDEEIVTVTIAELEKLFPDHFGQENPAKLLKSHVVKT
                     PRSVYKATPGRQQYRPLQSTPIANFFLSGSYTMQRYLGSMEGAVLSGKLTAQAISEARP
                     VANSSDLQTPTRPPATNAATA"
     gene            10001..10933
                     /locus_tag="IQ233_RS11045"
                     /old_locus_tag="IQ233_11045"
     CDS             10001..10933
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017320902.1"
                     /locus_tag="IQ233_RS11045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11045"
                     /product="phytoene synthase"
                     /protein_id="WP_193998959.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.8e-96, bitscore:
                     316.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 5.1e-86,
                     bitscore: 282.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQLPDSPPRMKTLVSVDESYKLCRQLIAKYSATFYLSTLLLSEE
                     KRPAIWAIYAWCRRTDELVDGPGCAMTTPETLDLWEEQLESIFAGHPVENYDVALADTV
                     RRFPMDIQPFRDMIAGQQMDLYRSRYETFEDLYLYCYRVAGTVGLMSTSVMGLDETRNT
                     APWNCQQQHYMPTAEEIALGIAKQLTNILRDVGEDAQRGRIYIPLEDLARFNYTEQDLL
                     KGVVDDRWRSLMQFQINRARQFYTKAERGITYLSTDARWPVWAALMHYSRILTIIERND
                     YNVFTQRAYVPQWQKLLSLPVAWMRSQVL"
     gene            complement(11155..11334)
                     /locus_tag="IQ233_RS11050"
                     /old_locus_tag="IQ233_11050"
     CDS             complement(11155..11334)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IQ233_RS11050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IQ233_11050"
                     /product="hypothetical protein"
                     /protein_id="WP_193998961.1"
                     /transl_table=11
                     /translation="MSTREVVGTRAKSRSVLRLQRGETKQHSGCIIPLGMSEKLIILSA
                     AMLARALWMTKAGR"
     tRNA            11445..11536
                     /anticodon=(pos:238274..238276,aa:Ser,seq:gct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IQ233_RS11055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="IQ233_11055"
                     /product="tRNA-Ser"
     gene            11445..11536
                     /locus_tag="IQ233_RS11055"
                     /old_locus_tag="IQ233_11055"
     gene            11774..13081
                     /locus_tag="IQ233_RS11060"
                     /old_locus_tag="IQ233_11060"
     CDS             11774..13081
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1282:
                     extracellular ligand-binding receptor"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196181.1"
                     /locus_tag="IQ233_RS11060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11060"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_193998963.1"
                     /transl_table=11
                     /translation="MPRINTTLALSIATLAAGLLLGACENANNTNSTTDSTPGNTTASS
                     QGLKIGTLLPATGDLASIGQQMSGSIPLLVETVNACEGVNGQPVSLIEVDDQTDPRAGA
                     AGMTKLATLDKVAGVVGSFASSVSTAAVSVAVPNQVMMISPGSTSPVFTQKAQQGDFKG
                     FWARTAPPDTYQALALAQLANQKGFKRVSTVVINNDYGVGFERAFVEAFEKLGGTVINK
                     DKPIRYDPKAQTFDTEAAAAFAGKPDAVIAVLYAETGSLLLKTAYQQGLTDGVQILLTD
                     GVKSPTFPDQVGKGADGRHLLAGALGTVPGSDGKALADFNKLWQEKKGSSPGEYAPQAW
                     DAAALLVLAAQAAQENTGVGISNKIREVANEPGTEVTDVCAGLKLLREGQDINYQGASG
                     NVDIDANGDVVGVYDVWSVAADGKIQVIDKVSPNPQ"
     gene            complement(13177..13821)
                     /locus_tag="IQ233_RS11065"
                     /old_locus_tag="IQ233_11065"
     CDS             complement(13177..13821)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196182.1"
                     /locus_tag="IQ233_RS11065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11065"
                     /product="hypothetical protein"
                     /protein_id="WP_193998965.1"
                     /transl_table=11
                     /translation="MNQPDETAKNTTNFLVEKQKEKELMHDVHLLLENLISREETTIKL
                     ILDYLYHVGSTNLINQKLRSRTLNRSLKLISRTSKPVFRILAWRWFQKNGSPLITNWLQ
                     SQVAFTSIEEAKVAIAELVLENPDTNLNPLPKPQYQLQEVKHLRSQVTLLTGILAAVVT
                     VFGGSFLWLGYSLERSHMQRIVELQTQVKTLEASVTDTIRSKDSEIILRTE"
     gene            complement(14174..14938)
                     /locus_tag="IQ233_RS11070"
                     /old_locus_tag="IQ233_11070"
     CDS             complement(14174..14938)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017804066.1"
                     /locus_tag="IQ233_RS11070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11070"
                     /product="hypothetical protein"
                     /protein_id="WP_193999113.1"
                     /transl_table=11
                     /translation="MNIIFLVYNTLRERQGLFYLPSLAVLTVLGSSLSAVAETVDTQML
                     AESSVNATSADAITLQQFPSAQTQEVANLTLTPVPGTALTSSAALIPESKPTAQSSPTQ
                     VAQADIDVRRSAPRARTYVGVGGNIGIGGGDSSLADGNFAVISKVGLTNTISVRPSAVF
                     GENTTILVPVTYDFSLQSADPFDEPLAIAPYVGVGAAIKTGDDSKTALLITGGIDFPLN
                     PQFTATASVNAGFFRETDVGLLLGVGYNFGGF"
     misc_feature    15239..15259
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.85"
                     /tool="antismash"
     gene            complement(15378..16691)
                     /locus_tag="IQ233_RS11075"
                     /old_locus_tag="IQ233_11075"
     CDS             complement(15378..16691)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196186.1"
                     /locus_tag="IQ233_RS11075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11075"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_193998967.1"
                     /transl_table=11
                     /translation="MVNPINQLLVQAQAASDAADWSLVTQYLQKLMLTVDSNHPEIVKH
                     REYLLKLALSILEMGDFQQRWDIAKVLRQLGNIAIPPLIDILEDEDAEEDLRWYAVRTL
                     GEFQHPEAIVSLVDLLKTSENQELKAMAASALGQMGTLAITALTQLLAEEQTRLLAVRS
                     LAYIRTQETITPLLSVVQDSQAAVRSATLEALSSFHDQRVPPVLLNALDDVSATVRRAS
                     VLALGCRPDLCLELDLVARLQPRLSDLNLEVCCAAAIALSRMGTDAAAQHLFQVLISPN
                     TPLKLQLEIIRALVWVETLSGLAYLQQALYHSRSQTLWQEIITVLGQVQKPQLMTPSAE
                     ILLDILQSPHLLTVAHPLEARIKSAIALGLGQLGNKQAVEPLILLLADGNQIVRLNAIA
                     ALKKLDATFAYQQLQQLANNSTLTPDLQQGIAIALAEW"
     gene            complement(16832..17242)
                     /locus_tag="IQ233_RS11080"
                     /old_locus_tag="IQ233_11080"
     CDS             complement(16832..17242)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006196188.1"
                     /locus_tag="IQ233_RS11080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11080"
                     /product="ubiquinol-cytochrome c reductase iron-sulfur
                     subunit"
                     /protein_id="WP_193998969.1"
                     /transl_table=11
                     /translation="MKRRDFINWVGLGAIISSLPIAIAACSEQSITSDDWQTVGTVAEL
                     DQDGQLLVKNWPSVNVLVVGTSKSGNLIAVDPTCTHSGCTVTWQTEGNKFNCPCHGAEY
                     GSDGQVQRGPATEPLKTYTAKIENNSVLVKQN"
     gene            complement(17299..18987)
                     /locus_tag="IQ233_RS11085"
                     /old_locus_tag="IQ233_11085"
     CDS             complement(17299..18987)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012407708.1"
                     /locus_tag="IQ233_RS11085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_11085"
                     /product="NAD(P)H-quinone oxidoreductase subunit 4"
                     /protein_id="WP_193998971.1"
                     /transl_table=11
                     /translation="MMADQFPWLTAIVLLPFIAAMVIPVLPDKDGKWVRWYALGVGVVD
                     LILMCYAFWHHYDASNATFQLEENYTWMPQLGLNWAVAVDGLSVPFVLLAGLVTTLAIF
                     SAWQVDRRPRLFYFLMLVLYSAQIGVFVAKDLLLFFIMWEVELIPVYLLICIWGGQKRR
                     YAATKFLIYTAAASIFILVAALAMGLYGGGNVSFDLVDLGLKDYPLNLELLLYAGLLIA
                     FGVKLAVFPMHTWLPDAHGEASSPVSMILAGVLLKMGGYGLIRLNLGILSDAHIYFAPV
                     LAILGVVNIIYGALNSFAQGNMKRRLAYSSISHMGFVLLGIASFTDLGISGAMLQMISH
                     GLIASVLFFLAGVTYDRTRTMIMDDLGGLGQVMPKVFALFTISAMASLALPGMSGFVGE
                     LAVFVGITTSDVYSSAFCIVTVFLAAVGVILTPIYLLNLLRKVFYGSSAALMCDINNAA
                     LENQEDEGTACFGTDCLLPDETIYSDAKPREIFIAACFIVLIIGIGFYPKLAMQMYDVK
                     TVAVNAQVRQSLMTIAQTNPQIYAQGLLVPTIATPEVAPVLGVVK"
ORIGIN
        1 ttgtgatcaa taatcttggt cgcatcccta tatccgccga ttattttgaa tggcgtggga
       61 tgcggattga agtcatggat atggacggta accgtgttga taaagtgcta gtaataccaa
      121 ggatcaatga ggaagtagaa actacgggtt taacttaaag tagggaagaa aaaactcccc
      181 actccccact ccccactccc cactccctaa gtcttcgata accgcttaac ttcagcacct
      241 gctaacatct catgggcttt tgctaacatt tgcggaattt tctcggcgtg gggactattg
      301 gcgagagatt gtcccaagtc gagttcatct agttggtctg ctttgttacc ggggaaccaa
      361 tgactagcat tacccagtag gttgtaacgc attttggcgt agtctactaa atcgtaggcg
      421 atcgctaaat tccacaacca caaaatcaca cgaatattca cttctcccgg tgttgcttcc
      481 caggtaggta aattcgtctc ccaagtcttt acccagtctt ctcctaaagt tgcgatcgct
      541 tcttgttcta acttactcaa aattggcggc aaaaattcct ccgcccgatc taagtaatct
      601 aaagttttca gatgttcatc aaaatcttca ggtctggctg cacccaaact caaagtatgt
      661 acattttcat gactcagaca aaacaaatca ttaaacacca tcggacttaa aggggcgcaa
      721 agattaacta acttttgcgg tggtttatat agcatccccc ctttatctga aggactaata
      781 ataaataccc ccatatcatg actgttagcg gctgtaattg cctcccaatt ccattgatta
      841 atgtaatacc aatgcaggtt gacataatca aattggttag tattaatagc ctggataatt
      901 acctctttag gtccatgagt agaaaagccg ataaatctca cttttccttc tgcttgtagc
      961 tgccgcgcca catctaaaca gccaccgtca cgcatactat agtcgaaaga ttcagcatga
     1021 tttatgccat gtattcccag taaatccaca taatctaact ggagattttg cagtgattgt
     1081 tcaaacgttt cgcgaaattt ctgggaatct gcaaccgggc cgacttttgt ctggacaatt
     1141 aatttctcac ggggaaactt cggcaatatt tgccccaatt gtatttctga tgtaccataa
     1201 ccacgggcag tttcaatgtg attaattccc acttccagag agcggcgaat agtcgcttct
     1261 agattagcct gattatctgc cggaatttcg gaattaggaa catcttgcca tttgaattga
     1321 tatctcatac cgccacaaga aaaaacaggc atctgtaatt ctgtgcgacc aaatcttttg
     1381 taaagcataa agacgtagat atactgcatt tcgtggagac gcgactaatc acgtctcaac
     1441 ttaccaatgg aaatttccca aaaatagtag ggtgggttag cgtagcgtaa cccacaatta
     1501 tcctaatgtc ctaaccctac aaattaattg gggatttgat tccttggaag ttgctaaaca
     1561 ggatcttgta actccgccgt gcggactgaa agcagctgta tctgattacc ccgttgcact
     1621 ttcacattta acaactgacc caggcgactg ttgtctacaa ggttctgtaa tttatcagca
     1681 ctggtgacgg gttcacggtc aatttgcaca atcacatcgc cacgtcgcac acccgcattc
     1741 gcagctgggg aattaggtat aacccgcatc accaaaaccc cattaatttc tggtatttga
     1801 atgggagagt tggggtcagt attattctgc tttgctaatt cgggcgttaa agttaccatt
     1861 tgcacaccta aataagggtg aataactttg ccgtcacgtt gcaattgcaa ggcgatcgct
     1921 ttagccttat caataggaat cgcaaaacca atacccatcg cgtccggacg aatagctgta
     1981 ttaatcccaa ttacttcgcc ccgttcattc aatagtggac ccccggagtt accaggatta
     2041 atcgccgcat cggtttgaat aaagtccaag cgtttgtcag caattcccac ttgggcgctg
     2101 gaacgtttga gggtgctaac aattcccaaa gttacggtat tatcaaatcc taaaggatta
     2161 cccactgcga tcgcccagtc tcccacttgt actgcatcag aagaacccaa aggcgcaaca
     2221 ggtaaatctt tatcagggtt aatcttcacc actgctaaat ctgtgacttc atcaataccc
     2281 tgaactttgc cttcataggt gcgaccatct ttgaggcgga ctgtgacttt atcagcttta
     2341 tcaactacat gggcgttggt caacaccaga ccacctttgt caataatgaa acccgaacct
     2401 agaccacgca attgttcaga aggcaactgt tggggaaaac cctcaccaaa aaatcgccgg
     2461 aagaatgggt cttccataaa tgggtccata cgacgggtaa tagtgcgttc agtgtcaata
     2521 cggactactg ccgttcccac acgatttaca gccgctgtga caaagctagt gctacctata
     2581 gccgcagttg ctggtgattg tcgggcaatt acatctaagg cagcagtagc agtctcagca
     2641 tcaggtgcag gttcggcttg agagggtaat acctgccaag tgctgaccgt tagtgtaacg
     2701 ccgataatta gggctaacac ataagcagca aattgacgta tagaacttga tatttgggag
     2761 aattgcataa ttacaaccta atatggcagc ctaatttttg cctaaaaatc tatttacagt
     2821 tatttttacc gaatggcaga ttattcgtca taaactacct atatcaaaat taatagaata
     2881 tttaacatca tagctattat ggagattcac cctttctagg ttcgggttcc acccttgaat
     2941 cagattctga cgatgactta agcaaagcga tcgctaattg gcagaaatac tttttccctt
     3001 accaattatc ctctaggcta ggatcttaat agtaccagtg ctttggcaac atgaactcat
     3061 gaacggatca aaccgattag ctaaaaaatc tgtgccggca tcccaggcag gagaaaacgc
     3121 ccagaatcat catgtagaag accagaaaaa tcatcctcat gagcctggaa agtcggtaca
     3181 tcctcacgtt catagtgaag agtcactacg gaaaattgtt aatcgactat ctcggataga
     3241 aggccatgtt cgcggcatta aaacaatggt gcagcatgat agcccttgtc ctgatgtttt
     3301 attacaaatt gcagctgtgc gaggcgcttt ggataaagtc gcgagaattg ttttggatca
     3361 acatttaact gaatgtattg ctagagctgc tcaagaaggc aatatggaag tggaaattga
     3421 acagttaaaa gctgctttag atcggttttt accttaaaat tccccactcc cctcaaaaca
     3481 acaagcgatc gccagttcag cgtgttgctg taggatattt ttatccaaag cataaatctt
     3541 atgctgggga gttaccgcca gtaggttttc aattctgtct ctagctgcgg ccacaactga
     3601 ttcatccaga ctacccctgc ttaaagaatc agcaaaatcc tcagccatct gataagttcg
     3661 ttcaatagat aatgaattaa tattccgcga gacaataaac aagtcacagc cagcatcaaa
     3721 agcctgcgcg actgtcccac tttcggtaaa catatctgag acagctttca tatcgaggtc
     3781 gtcagataca accactcctg caaaacccaa ttcttcccgg aggatctttt tcaggatagc
     3841 tggggagagt gtcgccggaa attgcggatc tattttggga aacaggatat gcgccgtcat
     3901 gattaaagga atttgctttt caatcagcgc tttaaacgga atcaattccc gaagccgtaa
     3961 ttcttcaagg gtgagattga gtactggtaa ttcaagatga gaatctttgc tagtgtctcc
     4021 atgtccagga aagtgtttag cacatcctaa aattccccct tcctcaagtc ccctatagta
     4081 ttcacacaca ccttcagcag ttgtttccgg gttgcgacca aaggcacgcg gaccgataat
     4141 cggattttga ggatgggaaa aaatatctgc tacaggtgac caggataaat ttattcccaa
     4201 agatttcaat tccaaagctg tagcttttgc gacttctctt gcgtgggatt tccacaacaa
     4261 agcataagga aatcgggtaa ttggtaacgg tgtcctaact actcgtcccc cttcgtgatc
     4321 taatgtcata aacattgagt cacgttcagt atattctctg atttgctcgt tgagcttctg
     4381 gaagctttct agccaaactt cataaggggt agcatccaga aagtttttag caaaataaat
     4441 taccccaact ggttttaatt cactcagtgt acgtttatcg tcatcactta acgaagtacc
     4501 tgaaatacca agtattaagt gatgtccaaa gcgctctaac tcttgcgata cagccataat
     4561 gcttcaccta gacttgtcta accaacaact gggattttca actttcagga aataaaaata
     4621 gtacttatac caattatttg tgaggctgca tattatttta ccccacccct tagcccgcaa
     4681 aaatccggtt ccctcctcgc ttgcgctacc gtgtacacac aagtgatcga atcgccccct
     4741 aacccccaat tatgggggaa caagaatttt caaagtcccc cattttaccc ccaaatttgg
     4801 gggtcacggg ggcaggggat ttagggggca aaacaggctc aaacgcagac aggcaggact
     4861 tgtgtgtaca ccgtagcctc gcttgcgggg agggttagag agaggttctt tttatgcatc
     4921 tttaatataa aattggtata ataccaattt aaaaatcttt gccatgccat aaagcggctg
     4981 tatgggctga cctgatgata ctcctactta tgtatctgga gtacatattc acaagaatgc
     5041 gctcatatgc ttgctgtata aaattatata agttttgcta gccacgacat cggcaataca
     5101 ctgatccaaa actctgatgc agttatcccg tgactccgac ttttgatcag cctgggagtc
     5161 tcaaaaaggc acattgtggc agcaaattta gatggctatt tccactagat ttagcaacta
     5221 cccacacttg tttatagtat tatttaatac tcgattttta taaaaatgtg gctttttaat
     5281 tccatgttta aagattttac gcaccatatt tcgtaagcta gcgtctcctc tcaacacgat
     5341 atctctgaga ttctgttcgg ggcgacctcg aaaagaagta acatgatagt acttgtgtac
     5401 atcagcaggt tttggcgaaa aatagtagtt agatacacaa cagcgctgac catgataatt
     5461 aatggggcta acggagtgcc aagaagtttt attagtcacc ataataacta gccgattgaa
     5521 cttactgtga atagttctac aaggctgctt taaatcttga tcccaaagct ctaagttacc
     5581 gccataattt tcttgccaat tgggagttac atagtacagt aaattcaaca cacgatagtt
     5641 actgatatct ttatcatggg aattatctag atggggattt aaaaaacagc cataatccat
     5701 gaggctaaca ccaccagcat aaaggtattc atctggcatc aattgttcca atcccgttat
     5761 ttcggcaatc aggttcacta ttctagtatc ctgaaacgca tagataattt cttctaagag
     5821 cgggtcatac ttgtctaatt gtataccaac gtacttatgt tctctcaggt cttttaactg
     5881 caataagttt tttttatcgg gaaatgcatg atatattttt aatacatcct cttcatttaa
     5941 taaatcatct aagtaacagg tatttatcct gttctcgatc ataaattgtt tttttaaagc
     6001 cgatttagat tgttcaagtt tatttaaaat ttgctcggta taataacttt ttgaagtttt
     6061 ggttagcatt tacaattttt tccggatcga gtaaaaaaga tttgaatata atatagcatt
     6121 tttagaaaaa tggtctaact gaagactaaa aaaatttaaa attattacat aagtcagttt
     6181 tatttcacaa aaaaaataat tatttgggga tttttcctgt taaatttata ctaaattacg
     6241 ataggcaacg ataaatatac ataattgtcc cgaaaataat cgctgcaacc aaaagtaatt
     6301 tgctatactt cgtgctatca aaaagcaaat aagtaaatac acgcttaaat aattgactat
     6361 atgttaaaag aagtggatac aaattgctct cagtattttg ctcaaccaaa caaaattgat
     6421 ggatgggatg aagatattat tatttgccct attttaaatc ccaccccagc tatccaagcc
     6481 aacagctact actttggaca tccagaatgg ggattaaatt attttcaagc ctgtcacaga
     6541 aatgaaaagt ttgtagaact gtggcaagct gtgattggta gttggcaaga taaagtagtg
     6601 gtggatatcg gttgtggccc aggcaatgtc tatgcctctc tcaaagagtt ttgtggtgaa
     6661 ccgcagttat tactgggtgt agatgtttct ctcggcgcac tgaaaatggc tcgccaactc
     6721 ggatatacag cagtcctagc agatgctcaa aatctacctt ttgtttctgg gtttgctgat
     6781 attgtgatgc ttaatgctag cttgcatcat tgcgatgata tgccaaaagt tttgcaagag
     6841 gcagctaaat tggtacgtcc tggcgggctt ttaattacag atcacgatcc tcaaaaaagt
     6901 gcttatcagt ttaaaggttt aggttcacta ctgtggaaaa tacggttacc aatttataag
     6961 tatattaaac gtgggggaca ttctagctca gaggagcaat tctggggctt ggcaacagag
     7021 gtacatcaca aagcgtttga tggtgtgaca tcagagatgt ttgatcaagt cttagaaccg
     7081 atgggcttta gagttaaggt ttacccccat aaccatactg tcggtgcaga agcattaaag
     7141 ggtaattacg gtaagccttt ttggaagtat cgtctagctc aaagactatc aggcatagac
     7201 cccaattctc tagaagctgc attgtcgttg atgtgtgttg ccacacggta ttgatcctaa
     7261 agatggctat gctagctttg tcattgacgt tttaatttct ctgcttcaat gatccgaatt
     7321 gccaggatag tctcggctaa aacccgatga aatacgtaat accaaccatg ccaaccatcg
     7381 aaaatccagc cttcgatgat caagcaatag agaaagacca tcccaggagc caagattttt
     7441 tttctgcgga tacgatcaac ccaatcaagt tcgttgatgg gagtttctag tattttcttg
     7501 gcttcaagta ctgtataacg ttcttgtgac cataaccaac gactaaatgg tttgcgatcg
     7561 tcatggtaga gataagcaga taggacatct gatttaccag tcagttgtaa aacttgtgta
     7621 tgtccatcat caatataaat agctttgctt ttttgaaata gaacttgacg aggcgggagg
     7681 attctggtgt tacgcacggg tttgccaaac acacaatact tgaatctgac aaagtagcca
     7741 tcaatttctc catccatcgg taaagcggct atttccgaga ttaaatcatc tgtaactata
     7801 tagtctgcat ctagagaaag cacccaggga gatttgactt gttctaagcc atagttccat
     7861 tgtttaccgt gggtatcaaa ttcacgctta aatacctgga cttgtgaata ggagtgaaga
     7921 atttccaggg ttgtatccgt actataacta tcaataacta tgattttttt tgcccaagtg
     7981 agatgctcaa gggtgcgtct aatattggcc gcttcattat aagtgagaat cagaggagta
     8041 atgtgttcta acatggatac aataatttca ttagaattag agcaattctc tgtagtaggc
     8101 gtttgcatag aaaatgagct aatttattta gtctgtcatt gattcttgtt attggatagc
     8161 atagataagc tggaatttgt caatttttta aatgtaaatt atctgatttt ccggagttag
     8221 atcgtaattt tggtttttgt ggaatgtatt tgactacatt gatggtaata aaaacacata
     8281 ataatagcac tagataaaaa tttatgtgag attttaccca attaatcaca taaattaacg
     8341 cagacctgga gaatatttga gactactggc aaaaaattag taggaaacga aggaatcatt
     8401 gagtgcttga gtggtaatga tgctggcgct ctgctgtggt tggtggatct cagtaaaatt
     8461 gcctttgcca gaagtttttg gagaagcgat cgcacaaccc ctgccaaatg taacggattg
     8521 caacgtataa tgagaacgac aaaaggatca aaaaatattg aaaggcagta agttgaaatg
     8581 cgagtagcga tcgcgggtgc tggactagca ggattatcct gcgcgaaata tctcacagac
     8641 gcaggtcaca ctcccattgt cttggaaagc cgggatgtac tgggtggtct ggttgcggcg
     8701 tggaaagact ctgacggcga ctggtacgaa accggattac acgccttctt tggggcatac
     8761 cccaatatgc tgcaattgct gaaggaattg ggcatcgagg acagacttca gtggaaagag
     8821 catacactga ttttcaatca accggaaaag cctggtacac tatcacgttt tgatgttcca
     8881 gatattccat ctccttttaa cgtgattgca tcgattcttc gcaacaaaga tatgttgact
     8941 tgggagcaga agattcggtt tgcaattggc ctgctaccag cagtggttcg gggtcagcag
     9001 tatgttgagg acatggacaa atacagcttc ttagagtggc tggaaaggca aggagttggc
     9061 gaacgcgtca ctagtgacgt ttttatcgcc gcgtgtaagg cgctgacctt tatcaatccc
     9121 gaagaagtgt ctgccacaat tctcttaact gcactaaatc gctttctcca agaacgatat
     9181 ggttccaaga ttgcgttttt agatggttcg cccacagagc gattgtgtca gccgatggta
     9241 gattacatca ctgagcgggg tggcgaagtc cgcctcaact cgcctttaaa acagattttg
     9301 ctgcaccctg atgggactgt caaaggattt ttgctcaggg ggttaaacgg cgctgaagat
     9361 caagtcttga cggctgatat gtatgtatcc gccatgtcag ttgacccact gaaggtgatg
     9421 ttaccagaac cttggcagca aatggagtat ttccagaagc tagaagggct ggaaggcgta
     9481 cctgtaatta atgtacattt gtggtttgac cggaaactca cagaaattga tcacctcctc
     9541 ttttcgcgat cgcccctcct cagcgtttat gctgatatga gcaatgcttg tcgtgaatat
     9601 gctaattctg agcgttccat gctggaatta gtcttagctc cggcaaaaga ttggatcacc
     9661 aaatcggatg aggaaattgt taccgtcact attgctgagt tggaaaaact cttccccgat
     9721 cattttgggc aagaaaatcc cgcgaaattg ctgaaatctc atgtggtgaa aacaccgcgt
     9781 tcagtttaca aagcgacccc aggtcgtcaa cagtaccgcc ccttacagtc aacccccata
     9841 gctaacttct ttctctcagg gagttacacc atgcaacgct atttaggcag tatggaaggt
     9901 gccgtacttt ctggtaagct gacagcgcag gcgatttctg aagcacgccc ggtagcaaat
     9961 tcctcagacc tgcaaacgcc aacccgaccg cccgcaacga atgctgcaac tgcctgattc
    10021 ccctccgcgc atgaaaacgc tggtctctgt agacgagtcc tacaaacttt gtcggcaact
    10081 tatagccaag tattccgcga ctttttacct aagcactttg ctcctgagcg aagaaaaacg
    10141 tcctgccatt tgggcgattt acgcttggtg tcgccgcaca gatgaactgg tagatggccc
    10201 cggatgtgcc atgactacgc cagaaaccct agacttatgg gaagagcagc tcgaatcaat
    10261 ttttgctgga cacccagtgg aaaattatga cgtagctttg gctgatactg ttcgacgctt
    10321 tccaatggac attcagccct tccgggatat gattgctggt cagcaaatgg atttatatcg
    10381 tagtcgctat gaaacctttg aggatttata cctctactgt taccgcgtcg ctggtactgt
    10441 cggcttaatg tcaacgtcag tcatgggatt ggatgaaacc agaaatacag ccccgtggaa
    10501 ctgtcaacaa cagcactata tgccgactgc tgaagaaatt gccttgggaa ttgccaaaca
    10561 actcacaaac atcctcagag atgtaggtga agatgcacaa cgtgggcgaa tttatattcc
    10621 tctagaggat ttggcacgat ttaattacac cgagcaagat ttgttgaaag gtgtagtaga
    10681 tgaccgctgg cgctccctca tgcaatttca aattaacaga gccagacagt tttatactaa
    10741 agccgaaaga ggtattactt acctatcaac tgatgcccgt tggcctgtat gggcggctct
    10801 catgcattac agtcgaattt taaccataat tgaacgcaac gattacaacg tgtttactca
    10861 acgtgcctac gtaccccaat ggcaaaaatt actttctttg ccagtagcgt ggatgcgatc
    10921 tcaagtgctt taatcaggtc agtagtcaga ataattcgta attcgtaagt tttgcacccc
    10981 ataaataaat tgagcaaaac ctgaaacatt gactgcattt cgtttttatc cattgataaa
    11041 ttaagtagct ctgtctatga attacgaatt acgaattatt taattaatta gtcattggtc
    11101 atttgccatt cgtgagtgag tgcagtctga tcccagggga atcagccaag ggattcatcg
    11161 accagcttta gtcatccata aagcccgtgc gagcatagct gcactcagga ttatgagttt
    11221 ttctgacata ccgagtggaa ttatgcagcc actatgttgc tttgtttccc cccgttgtag
    11281 cctgagaaca ctcctagatt ttgccctagt tcccaccact tcccttgtgg acatggtatt
    11341 tccaggacta atgactgagg acgaatgact tggcaaagtg gtttgataat tgacagttga
    11401 ctaactcaaa aaagtctgct actattatta tctgtagccc acctggagag gtggctgagt
    11461 ggtcgaaagc gacagattgc taatctgttg tacggcaggt aactccgtac cgagggttcg
    11521 aatccctccc tctccgtttt gctgaattga aacacaagtc ttgagtttac tgtctagcca
    11581 taaatcaagt ttagctagag tcagtcttac caaggtcaaa tcaaccaaca aatattgatg
    11641 tgttggtaaa cagttttact tctctgggta gatgttatca tttatccttt ggagtctgtt
    11701 aagatggggc taatttaaaa acttagctgg aatcttagtt ttaggctcct atatctgagg
    11761 agtggaataa actatgccaa gaattaatac taccctagcg ttgagtatag ctaccctagc
    11821 agcaggtttg cttttgggag cttgcgaaaa tgctaataac accaatagta caactgatag
    11881 tactccaggg aacacaaccg ctagtagtca aggattaaaa attgggactt tattaccagc
    11941 aactggtgac ctagcttcta ttggacagca aatgtcaggc tcaattccct tgctagtgga
    12001 gactgttaac gcttgcgagg gcgtgaatgg gcaaccagtc tcattgatag aagtagacga
    12061 ccaaaccgat cctagagctg gtgcggcggg gatgaccaaa ttggcaactc tggacaaggt
    12121 agctggtgtc gttggttcct ttgctagtag cgtttctact gctgctgtct cagttgccgt
    12181 accgaatcaa gtgatgatga tttctcctgg tagtactagt ccagttttta cacaaaaagc
    12241 ccaacaaggc gactttaaag gtttttgggc gcgcacagct cctcctgata cctaccaagc
    12301 attagcatta gctcaactag ctaatcaaaa aggcttcaag cgagtttcca cagttgtgat
    12361 taataacgac tatggggttg gatttgaaag agcatttgtc gaagcttttg aaaaattggg
    12421 tggaactgta attaataaag ataagccaat ccgctacgat cccaaagctc aaacatttga
    12481 caccgaagct gctgctgctt ttgcgggaaa accagatgca gtgattgccg ttctctatgc
    12541 tgaaacaggc agtctgctcc tcaaaactgc ttaccagcaa ggtttgactg atggtgtgca
    12601 aattctgctg acagatggag tcaaatcacc cacttttccc gaccaagtag gcaaaggcgc
    12661 tgatggcaga catctcttag ctggggcgct aggtacagtc cccggttccg atgggaaagc
    12721 tttagcagat ttcaataagc tttggcaaga gaaaaaaggt agttcccctg gggaatatgc
    12781 tccccaagct tgggatgctg ctgctttgtt ggtactcgca gcacaagccg cccaggaaaa
    12841 cacaggcgtt ggaatttcta ataaaatccg tgaggttgcc aatgaacctg gtacagaagt
    12901 tactgatgtc tgcgcggggc tgaagttact gcgagagggt caagacatta actatcaagg
    12961 tgctagtggc aatgtagata ttgatgccaa tggtgatgtt gtcggtgtct acgatgtttg
    13021 gagtgtggca gcagatggca aaattcaggt gattgacaaa gttagtccta atcctcaata
    13081 gtagctccca caggctggag gttgaagtta cagcgtcagg actttagttg tcaaacaggg
    13141 ctaaagtctt gacttgagaa atgcgagagt taggctttac tctgtccgca gaataatctc
    13201 agagtcttta gacctgatag tgtcagtcac gctagcttct agagttttga cctgagtttg
    13261 taattctacg attctttgca tatgcgatcg ctctagggaa taacctaacc agagaaagct
    13321 accaccgaac acagtcacga ccgcagccaa aataccagtc agcaatgtca cctgggagcg
    13381 aagatgtttt acttcctgaa gctgatactg aggcttggga agaggattca ggtttgtgtc
    13441 cggattttcc agaaccaatt ctgcgatcgc tactttcgct tcctctatgc ttgtgaaagc
    13501 tacctggctt tgcaaccagt tagtaattaa tggagaacca tttttttgaa accagcgcca
    13561 ggccaaaatt ctaaatactg gcttggatgt cctggaaatt agtttcagac ttctattgag
    13621 agtccgagaa cgaagcttct ggttaatcag gttagttgag ccgacatgat aaagataatc
    13681 taatattaac ttgattgtag tttcttctct agaaatcaaa ttttccagca ataaatgaac
    13741 atcatgcatg agttcttttt ctttttgctt ttctaccaga aaatttgtgg tgttcttagc
    13801 tgtttcatct ggttgattca tatatatacg ccagttttta attaaatatt tatttgttat
    13861 tattcaactt gaaataattg ctgcccatct ccaaagctag aaagtggcat gatttggtaa
    13921 actgtggtgt gacttgatcg cagtttagct gtgaaagtag atattttgaa ttatcgcaga
    13981 atttaagcat ggtatcaaga tgaaaaaata tgtaatttca agtgatactc atgatgtcac
    14041 cgatatcact cgttataact attaactcac tattttatag tctcttaggt gttgattaaa
    14101 aaatcagaaa ctttaaagtt gccaaaggca aaagcgtaaa tcacttttgc cttttatttt
    14161 tcagattatg tgattagaag ccaccgaaat tgtaaccaac tcctaacaac aaaccgacat
    14221 cagtctctct aaaaaatcca gcattcacgg aagctgtggc agtgaattga ggatttagag
    14281 gaaaatctat acccccagtt attaacaagg ccgttttgga gtcatcaccg gttttaatcg
    14341 ctgcacctac tccaacataa ggggcgatcg ctaagggttc gtcaaatgga tctgctgact
    14401 gtaagctgaa atcataggtg acgggaacca ggattgtggt gttttcgcca aacactgctg
    14461 acggtctgac cgatatggta tttgtcagtc ccactttact gatgactgca aaattgccgt
    14521 cagctaaaga tgagtcacca ccacctatac caatgttacc acctacacca acataggttc
    14581 tagcgcgagg agcagatcta cgaacatcta tatctgcttg tgctacctga gtaggagaag
    14641 attgagccgt cggttttgat tcaggaatta aggctgctga tgaagttaat gctgttcctg
    14701 gtacaggtgt gagtgtgaga ttagcaactt cctgggtttg agcgctgggg aattgctgta
    14761 aagtaatggc atcggcagat gtggcattta cagaagactc agctagcatt tgagtatcca
    14821 ctgtttcagc aacagcagac agactacttc ccaagactgt caggacagct agactgggta
    14881 agtaaaacaa accttggcgt tcgcgtaggg tattgtagac aagaaaaata atattcacat
    14941 tcactccttc cgaaatattg ccgtaatcgg cattctgtgc tgatgatttc acaaaattgg
    15001 gcgatattca aactgtaaca tttgaaattc agttatcaca tccttaagta gacataagtc
    15061 ttgttaaaaa tactgggtac tgagtagtaa aaatgaggag atcacaaggg caggcactca
    15121 ataaatgcac ggtatggggt gctggtgact cgaaaattaa ttgtttaatc gattgcgtag
    15181 catgattttc agaatgcgta acaacattga catgatattt atctatctct aggaggaatt
    15241 aaagtcgtgg tgattaatac taaataagta actattccga tcacctgacg aactttaact
    15301 gtaaatctcc tctgggctat ttttgatctg ggggagattt tttttcaatc cgctttggat
    15361 ctcttgtttg aaggacttta ccattccgcc agagcgatcg ctattccttg ttgcaaatct
    15421 ggtgtgagtg tggaattatt cgctaattgc tgtaattgtt gatatgcaaa agttgcatcc
    15481 agttttttga gtgcggcgat cgcatttaat ctcacaattt gattaccatc tgctagcaat
    15541 aaaattaatg gttccacagc ctgcttgttt cctaactgtc ccaaacccaa agcgatcgca
    15601 cttttaatcc tcgcctccaa aggatgtgcc actgtgagca gatgcggtga ctgcaaaata
    15661 tctaataaaa tttcggcaga tggtgtcatt aactgcggct tctgcacttg ccccaaaact
    15721 gtgataattt cctgccagag tgtctgtgat ctgctgtgat agagtgcttg ttgcaaatac
    15781 gccaaaccgg ataaagtctc cacccagact aaagcgcgga taatttctaa ttgcagcttg
    15841 agtggtgtat tgggtgaaat taacacctga aataaatgct gcgccgccgc atcagtaccc
    15901 attcgggaaa gagcgatcgc agctgcacaa caaacctcaa gattcaaatc ggataatcga
    15961 ggttgcaatc tcgccactaa atctagttct agacataaat cagggcgaca acctaaagcc
    16021 agcactgagg cacgtctgac agtggcggaa acgtcatcta aagcatttaa taggactggt
    16081 ggtacacgtt gatcatgaaa gctgctgagg gcttctaggg tggcgctgcg gactgcggct
    16141 tgtgaatctt ggacaacact caataaaggt gtaattgtct cctgagtgcg aatgtaagca
    16201 agcgatcgca ctgctaaaag tcttgtctgt tcctcagcca aaagttgagt tagggctgta
    16261 atcgccagag tccccatttg ccctaatgct gatgcagcca tcgccttgag ttcttgattt
    16321 tcactggttt tcagtaagtc cactaaagag actatggcct ctgggtgttg aaactcgccc
    16381 aaagtgcgaa ctgcatacca acgtaaatct tcttcggcat cttcatcttc gagaatatca
    16441 atcaatgggg ggatagcaat atttcctaat tgccgcaaga ctttggcaat atcccaacgt
    16501 tgctgaaaat ctcccatttc taaaattgag agtgctaatt tcagcagata ttcccgatgt
    16561 ttaactattt ctggatggtt agagtctact gtcaacatca acttttggag atattgagtc
    16621 accaaagacc aatctgctgc atcggatgcg gcttgtgctt ggactaaaag ctggttgata
    16681 ggattcacca tgcttgcaaa tagggcgttg ctgaactatg aaattccaaa attaccttaa
    16741 ttttcttcct acctttgcgc ctttgcgcct ttgcgcgaac ctaattcata tttgaaatca
    16801 gcaacgccgc aaatagggtg aggaaagagc gctaattttg tttaactaaa acagaattat
    16861 tctcaatctt cgctgtgtaa gttttgagtg gttctgtagc cgggcctctt tgcacctgac
    16921 catcactgcc atattctgca ccatgacaag gacagttaaa tttattgcct tcagtttgcc
    16981 atgtcacggt gcaacctgag tgagtacaag tagggtcaac agcaatgaga ttgccgcttt
    17041 tcgatgtacc cactactaaa acattcacag atggccagtt tttgactagc aattgaccat
    17101 cttggtctaa ctctgccaca gtccccacag tttgccaatc gtcagatgta atgctttgct
    17161 cagaacaagc cgcgattgct ataggtaagc tactaattat tgcacccaaa cctacccaat
    17221 taatgaaatc acgacgtttc atagttctag aaattctctg taatacttac tgaccatcat
    17281 cttagcaggt caataaaatt acttgacaac tcccaaaaca ggcgctactt ccggtgtggc
    17341 aattgtagga actaacaaac cttgagcata gatttgggga tttgtttgcg cgatcgtcat
    17401 cagagattgg cgcacctgag catttaccgc cacagtcttg acatcataca tttgcatagc
    17461 cagcttaggg taaaacccaa taccgataat tagcacgata aaacaggcag caataaatat
    17521 ctcacgcggt ttggcatcgc tataaatggt ttcatcaggt agcagacagt cagtaccaaa
    17581 acaagctgtt ccctcatcct cctgattctc caaagcggca ttattaatgt cacacatcag
    17641 ggctgcacta ctgccgtaaa atacctttcg cagcaggttg agcagataaa ttggcgtgag
    17701 aataactccc actgcggcta ggaatactgt gacaatacag aaggctgaac tatagacatc
    17761 gctggtagtt atgcccacaa aaaccgcaag ttcgcccaca aagccgctca taccagggag
    17821 agctaaagaa gccatcgcgc tgattgtaaa tagtgcaaac actttgggca ttacctgacc
    17881 aagaccgccc agatcatcca tgatcattgt gcgagtgcga tcgtaagtca cacctgctag
    17941 gaagaacagc accgacgcaa ttaaaccgtg ggaaatcatc tgtaacattg cgccgctaat
    18001 gcctaaatca gtgaaggacg caatacccaa tagtacaaat cccatgtgag aaatcgacga
    18061 ataagccagc cgacgcttca tattcccttg ggcgaatgag ttcaacgcac catagataat
    18121 gttgacaact cccagaatcg ctagaactgg tgcaaagtaa atatgtgcat cagaaagaat
    18181 tcccagattc agccggatta gtccgtatcc gcccatcttt agcaatacac ctgcaagaat
    18241 catcgatact ggagaagaag cctctccgtg agcatctggc aaccaagtat gcatggggaa
    18301 cacagctaac ttgacaccaa aggcaatcag caatcctgca tatagcagca gttctaaatt
    18361 cagggggtaa tcctttagtc ctagatcaac taaatcaaaa ctgacattac cgccaccgta
    18421 aagccccatt gccaatgctg ctaccagaat aaatatagaa gccgcagccg tatagatcaa
    18481 aaattttgta gcggcgtagc gtcgcttctg ccctccccaa atacatataa gtaggtagac
    18541 aggaattaac tctacttccc acatgatgaa aaacagcagc aagtctttgg cgacaaatac
    18601 ccctatctgc gccgagtaca acaccagcat cagaaaatag aaaagccggg gtctgcgatc
    18661 aacttgccaa gccgaaaaaa tcgcgagtgt cgtcaccagt ccagctagaa gtacaaaggg
    18721 aactgataac ccatccacgg caactgccca attaagtcct aattgcggca tccaggtata
    18781 attttcttct agttgaaaag tcgcattgct ggcatcataa tggtgccaaa aggcatagca
    18841 catcaagatt aagtctacaa ctcccacacc caatgcatac catcgtaccc acttgccgtc
    18901 tttatcgggt agcacaggga taaccatagc agcaatgaat ggtagcagga caattgcggt
    18961 tagccaggga aattgatctg ccatcatatc actaagaaat aatacttatt tagagatcat
    19021 gtcatattat tcaacttttt aataattatt taatttgtat tgacaataga aaagtcgaaa
    19081 aatcaatcat gaattgccga taaacgccga tagaagcgac ttatacgaaa ggcttatggt
    19141 taccataact cacagaactc agcatttgct gccttcaact tgattctgca caacatattt
    19201 aaatacaact cttgtgggag agggcaaaga tgctcttcca aattgtgcaa attgaatgct
    19261 caacagctga catacaagaa tgaaggcggg gtgtatcaac ggttatgttt gataataaaa
    19321 aagactttaa tgcagaaatt gcatcgaatc gatacgtatt ttccaacttt atctaaaaaa
    19381 cgtaacaatt tatacgattt taactataat ctcaccttaa cctgatgagt atcaaaatcg
    19441 ttacataaac agtaaccaaa cctgcttgac aaattcccga aatgtccaag aatacaaccg
    19501 gttcccaact aactacaatt tgagttcact cgatacactt gcatcttgct gatgagtcac
    19561 ctgggaagac tcttgagtac aagaaattag ccacaaacag atatacatac gtgttaaatc
    19621 actaaacttt gtagacccag taatcaaaag atattgggca aatagcgtcc aaagttttga
    19681 ctggattaac cataagcaat gagagtcagt tcatgacaga tacagtaact actaccaaaa
    19741 ccaacctgaa taagtttgag aaactcaaag ccgagaaaga tggtctggct gtcaaagcag
    19801 aaatagaaaa atttgcggct ctcggttggg aagcaatgga cgtaaacgat cgcgatcatc
    19861 gcctcaagtg gctaggtgta ttctttcgcc cagtcacccc aggtaagttt atgatgcgaa
    19921 tgcggatacc taacggtgtt ctcactagcg atcagttgcg tgttttagcg gcagtattac
    19981 agcgttacgg agatgatggt agtgctgata ttactaccag acagaatatt caactgcggg
    20041 ggatcagaat tgaagactta ccagatatct ttcaaaaact ggactcagtt ggtttaacca
    20101 gcattcaatc aggaatggat aacgttcgta atatcactgg tgatcctgtg gctggtttag
    20161 atgcggatga gttattcgac accagagaat tagtgcagca agttcaagat atgctgacta
    20221 atcaaggaca aggaaaccca gagtttagca acttaccacg gaaatttaat attgcgatcg
    20281 ccggaggtcg tgataattca gttcatgcag aaattaacga tttagccttt gttccagctt
    20341 ttcaagaggg gagtggggaa tcgggagtgg ggagtagtga atctcaaaaa gtcttcggct
    20401 ttaacatcct tgtcggtggc tttttctcag ccaaacgctg tgaggcggcg attcctctca
    20461 atgcttgggt gtctccagag gatgtagtag ctgtatctag agcagtttta gaagtttatc
    20521 gtgacaacgg cttacgcgct aaccgcctca agtctcgctt aatgtggcta cttgatgaat
    20581 ggggtgtcga aaaatttcgt tcagaagtag aaacgctttt aggtaaaaca ctgttacccg
    20641 cagccgctaa agacgagatt gactgggaaa aacgcgacca tattggggta tataaacaga
    20701 aacaaccagg attaaactac gtaggtttaa atattcctgt gggtcggcta tatgcccaag
    20761 atatgtttga agttgccaac ttagcagagg tttacgccag tggtgaagtt cggttgacag
    20821 ttgagcaaaa cgtgatcatc cccaatattc ccgactcgcg tttagcaaca tttttaacag
    20881 agccgctact acagagattt ccagttaacc cagatatgtt aacgcgatcg ctt
//
