LOCUS       NZ_JADEWH010000002     27223 bp    DNA     linear   CON 23-DEC-2023
DEFINITION  Nodularia sp. LEGE 06071 N071000002, whole genome shotgun sequence.
ACCESSION   NZ_JADEWH010000002
VERSION     NZ_JADEWH010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nodularia sp. LEGE 06071
  ORGANISM  Nodularia sp. LEGE 06071
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Aphanizomenonaceae; Nodularia.
REFERENCE   1  (bases 1 to 604296)
  AUTHORS   Castelo-Branco,R., Eusebio,N., Adriana,R., Vieira,A., Brugerolle De
            Fraissinette,N., Rezende De Castro,R., Schneider,M.P.,
            Vasconcelos,V. and Leao,P.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-2020) Cyanobacterial Natural Products, CIIMAR,
            Terminal de Cruzeiros do Porto de Leixoes, Matosinhos 4450-208,
            Portugal
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: SPAdes v. nov/18
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 30x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/23/2023 19:29:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,867
            CDSs (total)                      :: 4,805
            Genes (coding)                    :: 4,703
            CDSs (with protein)               :: 4,703
            Genes (RNA)                       :: 62
            rRNAs                             :: 6, 7, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 3, 3 (5S, 16S, 23S)
            partial rRNAs                     :: 4 (16S)
            tRNAs                             :: 42
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 102
            CDSs (without protein)            :: 102
            Pseudo Genes (ambiguous residues) :: 0 of 102
            Pseudo Genes (frameshifted)       :: 22 of 102
            Pseudo Genes (incomplete)         :: 84 of 102
            Pseudo Genes (internal stop)      :: 12 of 102
            Pseudo Genes (multiple problems)  :: 15 of 102
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:23:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 176346
            Orig. end                         :: 203569
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADEWH010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27223
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..27223
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27223
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17223]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17223
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            1577..2470
                     /locus_tag="IQ233_RS04435"
                     /old_locus_tag="IQ233_04435"
     CDS             1577..2470
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1192: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006199037.1"
                     /locus_tag="IQ233_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04435"
                     /product="RNA-guided endonuclease TnpB family protein"
                     /protein_id="WP_193998017.1"
                     /transl_table=11
                     /translation="MWERNHGFPRFKKSGRMRSFSFPQLGTNPLNNGCVRLPVIGAVKV
                     RQSRSIPDGGVIKQARVVKRVSGWYVMLTVQWDVTVPSPMPHGEAVGIDVGLTSFVATS
                     NGLLVKRPRFFVDAERKLKLLQQRVSRKRLGSNNWKKAQKKVASLHEYVANCRKDWHRK
                     LSHQICNDAGMVFVEDLNLVGLSRGMLGKHCLDAGFGQFFNILEQTCFKRDAYFQKVDA
                     RKTSQICPNCGIETGKKELSERTHVCSNCGYTTDRDVAAAQVVLVRGLAAVGHTVKMLA
                     EGKFIGIPVKQESSHL"
     gene            complement(2767..4353)
                     /locus_tag="IQ233_RS04440"
                     /old_locus_tag="IQ233_04440"
     CDS             complement(2767..4353)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0046930 - pore complex [Evidence IEA]"
                     /GO_function="GO:0015093 - ferrous iron transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0033212 - iron import into cell [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006197785.1"
                     /locus_tag="IQ233_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04440"
                     /product="iron uptake porin"
                     /protein_id="WP_193997671.1"
                     /transl_table=11
                     /translation="MREFWKYLLVSPLFGGTMLFFGATVYAGEIPTTSVINNSEIKTEN
                     LTEDQVMAQITSVSQLSDVQPTDWAFQALQSLVERYGCIAGYPNSTYRGNRALTRYEFA
                     AGLNACLDRVNELIATATSDAVTQQDLGTLQRLQEEFSAELATLRGRVDSLEARTSELE
                     ANQFSTTTKLQGEVVAVMSDVLGGDRVNNQEITDNNTTLGARTRIQFVTSFTGRDTLFT
                     RIQANNILGPNIGTPEGNLFFAGADGTTNAAIDALFYKFPLGEKTQVIAIANAGAADDI
                     TSTVNLFDGDGSSGALSTFGTRNPIYNQIGGAGLGVTQQFGDSLSLSLGYLSGTANNPS
                     PKNGLFDGAYGALAQLTLRPSDRIALGLTYINSYKQPLLTGSNAATFQNVLQNDAAFSS
                     DSYGVQASIGISEKLVLGGWAGYTNSRALTGDRGEAEIWNYAVTLGFPDLGKRGNLAGI
                     IAGVEPRVTSSNIPGVDRDRDTSYHLEAFYQYQLTDNITITPGVIWLTSPDHNNDNDDV
                     VIGALRTRFSF"
     misc_feature    4427..4441
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.3"
                     /tool="antismash"
     gene            4680..5693
                     /locus_tag="IQ233_RS04445"
                     /old_locus_tag="IQ233_04445"
     CDS             4680..5693
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006197786.1"
                     /locus_tag="IQ233_RS04445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04445"
                     /product="metal ABC transporter substrate-binding protein"
                     /protein_id="WP_227788669.1"
                     /transl_table=11
                     /translation="MIWNRLRPRTGKQTRGILPLMAFLTLSVAVGCNQSNTDIGETSEQ
                     TPPAQEAAATPGATEKIKVVATFLPTYLFTKAVAGDAADVSILVPPTTEVHDYQSTPDN
                     VKAISTASILVKNGLGLEEFLDNTVKNAENPKLVEIDASKGIKILDKISLVDETVTEDG
                     HDHDQGNPHVWLDPVLVKQQVTNIRDGLSAADPANKATYEANTAAYIQELNNLNQEFQQ
                     TLQKTPNCTFITFHDAFPYLAQRYNVKQVAVVQLPEDQLSPADVQKAVKAVKNYNAKAL
                     FSEPGVDNKLLTSLAQDLNVTVRNLDSIETTAGDTNPQYYFQAMKTNLQTLEAGCK"
     gene            5776..6546
                     /locus_tag="IQ233_RS04450"
                     /old_locus_tag="IQ233_04450"
     CDS             5776..6546
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011321113.1"
                     /locus_tag="IQ233_RS04450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04450"
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="WP_193997672.1"
                     /transl_table=11
                     /translation="MTSPILKVEGLNVYQGSYLAVRDVAFELLPGTDTAIVGPNGAGKS
                     TLVKAILDLLPHSAGKIEIFGRPISKLGNLRHRLGYMPQNFIFDRSFPISVSELVGLGW
                     ANESKQQNSFFSQLWKKDRRKSVAIAEALRRTDAYHLKHQAIGTLSGGQLKRVLLAYCL
                     VIPRQLLVLDEAFAGVDIQGTTDFYALLNELKREEGWTVLQVSHDIDMVSRHCDRVLCL
                     NQTVVCTGQPEIALSPQNLLATYGLGFSPYKHNH"
     gene            complement(6766..7032)
                     /locus_tag="IQ233_RS04455"
                     /old_locus_tag="IQ233_04455"
     CDS             complement(6766..7032)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006197788.1"
                     /locus_tag="IQ233_RS04455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04455"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_227788673.1"
                     /transl_table=11
                     /translation="MAEFFSFLGDPNRLRILSFLANKELCVSDLAALLKMSESAVSHQL
                     RNLRVMRLVGYRKQGRNVFYHLHDNHIFHLYQAVAEHLDEPAE"
     gene            7282..8106
                     /locus_tag="IQ233_RS04460"
                     /old_locus_tag="IQ233_04460"
     CDS             7282..8106
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1245: ABC transporter
                     protein, integral membrane"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015078684.1"
                     /locus_tag="IQ233_RS04460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04460"
                     /product="metal ABC transporter permease"
                     /protein_id="WP_193997674.1"
                     /transl_table=11
                     /translation="MNFDFVNLLQFPFMQRAIAGAVLMGILGGLLGTFATLRQLSFFSH
                     AVGHAALIGVVLGVLLQLNPTWMLLPFTLVFGVVVLYLIDKTDLASDSVLSIVLSGALG
                     IGVILTSFVPGYRGNLMRVLFGDILAIDNTDLILTLILLIASSIFLFSTLQQQILLTIN
                     PDVAQVQGVPVQLYRYGFVILLSLAVAVAITAVGVLLVNAFLVIPASTAKLMSHHFNRF
                     LVLSIIVGSTTSLTGIMVSGIFNLPSGPSIVLVQFLFFVAVFLAVKLKFKAA"
     misc_feature    7295..7311
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: medium, score: 27.94"
                     /tool="antismash"
     tRNA            8185..8257
                     /anticodon=(pos:184564..184566,aa:Phe,seq:gaa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IQ233_RS04465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="IQ233_04465"
                     /product="tRNA-Phe"
     gene            8185..8257
                     /locus_tag="IQ233_RS04465"
                     /old_locus_tag="IQ233_04465"
     gene            8529..9953
                     /locus_tag="IQ233_RS04470"
                     /old_locus_tag="IQ233_04470"
     CDS             8529..9953
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015501 - glutamate:sodium symporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015813 - L-glutamate transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006194892.1"
                     /locus_tag="IQ233_RS04470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04470"
                     /product="sodium/glutamate symporter"
                     /protein_id="WP_193997675.1"
                     /transl_table=11
                     /translation="MFKLIDVFWAYILIAILILVGRLIRQRLGILRSLYIPSSIVAGII
                     ALLLGKSALGAIVQAINPKSPLVQGIFTENVQAVWSQSPGIFINIVFATLFLGQYVPTL
                     QQFWTKAAPQVAFGQAIAWGQYVVGLILAITILTPVFGLPPIVACLIEVAFEGGHGTSA
                     GMAATFTELGFTAGPDLSLALATVGLVSGVISGTILIHWGRRTGRIKVSREPLDNLENT
                     ENELPEEEPSVTIARKNLFRDLLIDPLSLNFGFVGLAITFGWLILEALRFIESITWGRG
                     GVELISYVPLFPIALIGGMIVQYILMRTRRTYLISRPLMENIGGLALDITIVTALASIS
                     LSVLGDNLAPFLILSIAGIAWNVCAFIFLGPHLLPFYWFERGIGDLGQSMGVTSTGLLL
                     LRMVDPDNRSGAFESFAYKQLLFEPIVGGGLFTAAAPLLIANFGSIPILLLTSFILAFW
                     LIFGFYNCKQLRKQSD"
     gene            10001..10288
                     /locus_tag="IQ233_RS04475"
                     /old_locus_tag="IQ233_04475"
     CDS             10001..10288
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015121433.1"
                     /locus_tag="IQ233_RS04475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04475"
                     /product="PqqD family protein"
                     /protein_id="WP_193997676.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.6e-24,
                     bitscore: 79.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.1e-17, bitscore: 57.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQLSLDCKISPAPNVLAQDLAGESVLLNLQTEEYFGLDDVGTRI
                     WQTLTDKDSIQSAIDVLVTEYGVESKQLQQDVENLIEELLANGLVEVSGT"
     aSDomain        10028..10276
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IQ233_RS04475_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.40E-25"
                     /identifier="RREFam002.1"
                     /label="IQ233_RS04475"
                     /locus_tag="IQ233_RS04475"
                     /protein_end="92"
                     /protein_start="9"
                     /score="79.3"
                     /tool="antismash"
                     /translation="ISPAPNVLAQDLAGESVLLNLQTEEYFGLDDVGTRIWQTLTDKDS
                     IQSAIDVLVTEYGVESKQLQQDVENLIEELLANGLVEV"
     gene            10260..10769
                     /locus_tag="IQ233_RS04480"
                     /old_locus_tag="IQ233_04480"
     CDS             10260..10769
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015121434.1"
                     /locus_tag="IQ233_RS04480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04480"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_193997677.1"
                     /sec_met_domain="PF13471 (E-value: 2.6e-23, bitscore: 77.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDWLKLAVRKLRSFWGLDRNSRWLLLQALLFFPLVTLSLKFGGLK
                     RTQSDLVRMLPPGKIVLPDSELTSQRLRDRSCKIIKTISMVQLAARYCQPWAKCLQKSL
                     VLWGLLRHQGINSELRIGVKRDAESFEAHAWVEYEGFVLNDTQNVRDRFAMFDRPIEVN
                     FPSRES"
     gene            10769..10996
                     /locus_tag="IQ233_RS04485"
                     /old_locus_tag="IQ233_04485"
     CDS             10769..10996
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015121435.1"
                     /locus_tag="IQ233_RS04485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04485"
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="WP_193997678.1"
                     /transl_table=11
                     /translation="MSVQTALQFIQQLRMDEGLKSRLLALNNHPDLASFVKLGAEFNLT
                     FTVEELKTAHKHDWGMRWLLHNSRLEDNRQ"
     gene            complement(10976..12226)
                     /locus_tag="IQ233_RS04490"
                     /old_locus_tag="IQ233_04490"
     CDS             complement(10976..12226)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015121436.1"
                     /locus_tag="IQ233_RS04490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04490"
                     /product="cytochrome P450"
                     /protein_id="WP_227788668.1"
                     /sec_met_domain="p450 (E-value: 2.6e-27, bitscore: 90.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQSQSESIAPPLPFNPRSPEFRANRYPTYDYLRTHHPIYYRSEGN
                     DWVLTRYADISEVLKNPIFGHAQKSIVSLETGTPAPINNFLGLRQESQRLMKLWLVRQN
                     PPTHTRIRPLLRSAFTQSHIQALRSHIQTTVDDLIDRVQDLGKMDIINDLAYPLTLGLN
                     CKILGIPPQQWHPQFKQWSVSLSLSLDLDVTPIANEQGLLAIAGLAEYFKSWIAQSRTC
                     SQPQDNLISTLIQAEAEGQLSAEELLANCILIFAAGHSTTENLIGNSILTLLNHPEQLH
                     LLQADPSLIETTIAEVLRYESSVHSIPRTTLSDIELSNQTIRQGEIVHCIIGAANRDPA
                     HFPNPNQFDIRRKPNPYLSFGQGIHSCIGIHLAKLVTEIAVNIIVSRLPGLSLATESLE
                     WEDSFMGRGLKSLPVVF"
     gene            complement(12461..13708)
                     /locus_tag="IQ233_RS04500"
                     /old_locus_tag="IQ233_04500"
     CDS             complement(12461..13708)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015121438.1"
                     /locus_tag="IQ233_RS04500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04500"
                     /product="hypothetical protein"
                     /protein_id="WP_193997680.1"
                     /transl_table=11
                     /translation="MYSTLVESLDVLLGTGIKSPSLEHLIGQDAALSLKALAGNLAPIF
                     QGGFECRLSANATQVDLQQCIVCNEQELDLLQEFMEVAISTCEETAYPEWLRLRDFLAE
                     WRSCLESIPEIWLEFDVDKNYGTPPPTPPRQRGGEITQGFGDQNLGNLLPISHSQGGGE
                     IKQGFVSIQPDLISSFVLPLPAIFFGLPQEVSPSVETYGIAAQSLNLLLGDLGWSGWED
                     NLYRCFAACPDGAFVSHIGVMLSRNSPALRVNVKRLQPHFLIPYLQQIGWQGDTVKVAE
                     LMEELFALVDRITVCLDVGDQIYPQIGLECIFLNQPDSESRWAIFLDYLVERGLCEVQK
                     REALLNWPGQINPLNSPAPWPHNLIAASVLQQRERFTVFERRLSHIKIVSQSQSPLVAK
                     AYLWFQHQWLSGASKI"
     gene            complement(13693..14682)
                     /locus_tag="IQ233_RS04505"
                     /old_locus_tag="IQ233_04505"
     CDS             complement(13693..14682)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015121439.1"
                     /locus_tag="IQ233_RS04505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04505"
                     /product="serine/threonine protein kinase"
                     /protein_id="WP_227788667.1"
                     /transl_table=11
                     /translation="MKLSESFRYKVYGLTLQVNQPLTGLIAAKSDAPVDVWVDLNGESQ
                     PSSAEIETISSGLNVLSKADGTYFHLWFRGDGQLDFYLDAGGSHISANWTCALLEEVNA
                     LLLGQVLGCALRLRGTLCLHACVVKIDQHAVAIVGESGAGKSTTAAALAKEGYSILSDD
                     IAVLKDDEQHWFVQPGYPRLRLWPQTIHALYGSESDLERIFSFSEKRFVELVGNSSETV
                     WKFHSDPLPLAAIYVLGKRHPELAAPMIETISPATAVMTLMTHRSVSHLKLGMDKQAQE
                     FAGLSRVAMTVPIRKVSRSDSLTALPQLCDAIVNDVGNITLLEQCTQL"
     misc_feature    14841..14856
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
     gene            complement(15183..15353)
                     /locus_tag="IQ233_RS04510"
                     /old_locus_tag="IQ233_04510"
     CDS             complement(15183..15353)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IQ233_RS04510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IQ233_04510"
                     /product="hypothetical protein"
                     /protein_id="WP_193997681.1"
                     /transl_table=11
                     /translation="MSQISTNQSNSANHKPYHTPELRKFGNIKNLTLASPTFNIDGIDG
                     GGSAFPNVYAS"
     gene            complement(15382..17223)
                     /locus_tag="IQ233_RS04515"
                     /old_locus_tag="IQ233_04515"
     CDS             complement(15382..17223)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015121442.1"
                     /locus_tag="IQ233_RS04515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04515"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_193997682.1"
                     /sec_met_domain="GATase_7 (E-value: 1.6e-24, bitscore:
                     81.2, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.9e-31, bitscore:
                     105.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGFIGIFNSNGQPIDPALLQQMTDLMTPQAPDAQDTWSNGSIGF
                     GHALLRTTWESEKERQPHSLDGNLWITGDIRLDRRRELIERLRASGCSVNNDAPDVNLV
                     LYTYQVWGDACLERLSGDFAFAIWDSRQQRLFCARDHFGIVPFYYAEMGNSLIFSNHIN
                     PIRLHPEVSDRLNEASIADFLLFSMNLDVATTTFADIQKLPPAHTLICSEGRVRIRRYW
                     QLPEAVERLNYQRPEDYIEQFQELFERSIADRLRTNSAGTHLSGGMDSTSIAATAYKLM
                     KATGSPVDFRAYTIIYKQLITDDEGDYATQVAEMAGFPLEYLVAEDYIPQAPPQDPEYL
                     YPEPLLIPTQVAEVEITRRISGYSRVLLAGFGGDPAFEPVPNEQYNSVHNQDFMLNPLG
                     YIRSLRRQLGLGTRLRQLLGIKQPGQKKRELPDWFNPDFAEQMQLEARLQDRLTGSPQR
                     DRYGMATAPLWSNIFAWSDPGFSGFPVKVRFPFFDLPLVLFLLSVPPKPWFENKFLLRE
                     AMPGILPDSVRQRPKTPLRGFAHYNWVQQQGIQPWMVELVNTSALTPYVKAERLLPKLQ
                     NVVKLTPIKYNQVIPTMQLAYWLRHKPCLEVNNRPIL"
     gene            17558..19354
                     /locus_tag="IQ233_RS04520"
                     /old_locus_tag="IQ233_04520"
     CDS             17558..19354
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015196574.1"
                     /locus_tag="IQ233_RS04520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04520"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_193997683.1"
                     /transl_table=11
                     /translation="MSLIKLIHTLRRAIQLVWQSSPLWTIFSIIFLFIQGILPLLSLYL
                     VKLIVDTLTENIATPNPLQTFKQLLLLILISGVVALFQNIAQSLSGLTNTAQSQIVIDH
                     IHDQIHAQSIAADLEYYENSQYYNALHRAQQQSSHIPPQILQHLVQIAQSAVSLVAMAA
                     LLISLHWAIGIILLITAIPTLLVRMKYAGKTYNQQKVLTSKEREAGYFNFMLTSLHYAK
                     EMRLLVLGNLFRRRFQKLRKQIRQEKLNLEIQRSLKQIIAQIGSTLVIFALSAFITYQT
                     LLGAITLGSLIMYYQAFQRGQVSLSQLLSSLAGLYENSLFLTNLFEFLDLKPNVTEPPL
                     PKPIPSEFKTGIDFDHVRFHYPQSTRPVLEDINFNIAPGEIIALVGENGVGKTTLIKLL
                     CRLYDPTAGNITIDGINIREFSPTDLRRKISVIFQDYVQYHLTAKENIWLGNLDILPES
                     KQIENAARDAGADVVISQLPQGYDTMLGKWFEGGEELSIGQWQKVALARAFLRDAPIII
                     LDEPSSALDPKAEAEIFDKFRQVVRGKIAILISHRLSTVKMADRIFVITDGKISECGSH
                     EELIQHRGTYARLFETQAKHYR"
     gene            19367..20590
                     /locus_tag="IQ233_RS04525"
                     /old_locus_tag="IQ233_04525"
     CDS             19367..20590
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.3"
                     /locus_tag="IQ233_RS04525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04525"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_193997684.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 4.9e-55, bitscore:
                     181.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLLQTNQPQKNNPNSQIFHRPEIQLLLYCSRTCINAVTAEKIQ
                     KLSEQELDWNYLLRIAARNEIIPLLYQSLKLICPKAVPKNILHQLQQCFQANASRNMFL
                     TTELLKLLDLFAAQNISAIPFKGPVFGQFAYGSLILRNISDLDILVEKQDFLRAKELLI
                     RHGYQHKYFGEHEAAYVQAQLIRDDGLVGVDLHYGITPRDFLFTLDTEPFWEHLTSLSL
                     AGKTVPNLSVSDALLVACVQPIKENWKSFKRICDIAELCKLCTEKDWQVFFEEMQKLGN
                     EKTFLVSLIMAHHLLEISLPKEVSEKIRVLPSLKSTTLEISEQFFSETPNDSDLSINWG
                     KIQLLRMSLYNNQNQIKYLAFVAFNINEKDKLMLPFPLPKYLYFLYYPLRLFRLLLTYK
                     IGLKDINL"
     gene            complement(20750..21703)
                     /locus_tag="IQ233_RS04530"
                     /old_locus_tag="IQ233_04530"
     CDS             complement(20750..21703)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016865004.1"
                     /locus_tag="IQ233_RS04530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04530"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_193997685.1"
                     /transl_table=11
                     /translation="MNQATLHQLKVFEAAARHSSFTRAAEELFLTQPTVSMQIKQLTKS
                     VGLPLFEQVGKRLFLTEAGRELFATCRQIFETIAQFEMTVADLKGLKQGQLRLAVITTA
                     KYFVPRLLGPFCQLYPGIEISLQVTNHERILERMVNNMDDLYIMSQVPENLDVSYEPFL
                     DNPLVMFAPVNHPLAKEKNIPIGRLTNEPFIMREPGSGTRRAVQQLFEEHGVKVKVKLE
                     LGSNEAIKQAIAGGLGISVLSRHTLMPDSSEFSILDVEHFPIKRTWYMVHPPGKQLSIV
                     ARTYYEYLLEATKKFAEETGFSAYPKLEDIPTSLGD"
     gene            complement(21978..22778)
                     /locus_tag="IQ233_RS04535"
                     /old_locus_tag="IQ233_04535"
     CDS             complement(21978..22778)
                     /GO_component="GO:0031469 - bacterial microcompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016950890.1"
                     /locus_tag="IQ233_RS04535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04535"
                     /product="BMC domain-containing protein"
                     /protein_id="WP_193997686.1"
                     /transl_table=11
                     /translation="METSNQHALSTIRKSRRRDSLKNTALGLVSTSSFPAIVGTADMML
                     KSAGVHLVGYEKIGSGQCTAIIRGGIADVRLAVEAGVQTAEQFGQLVSSLVIPRPYPNL
                     EIVLPINSRLSKLMEEGNQSSLSNLAIGLVETRGFPAMVGACDAMLKAADVHLAAYEKI
                     GAGLCTAIIRGTVANVAVAVEAGMFEAERIGELNAVMVIPRPLDEMENTLPLASCWIEH
                     REPLNIPVDVEEQVAEIEVLQLPDLSQIPAKFAEEVTEEIWKDE"
     gene            complement(22826..23578)
                     /locus_tag="IQ233_RS04540"
                     /old_locus_tag="IQ233_04540"
     CDS             complement(22826..23578)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010995038.1"
                     /locus_tag="IQ233_RS04540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04540"
                     /product="transferase"
                     /protein_id="WP_193997687.1"
                     /transl_table=11
                     /translation="MSVPPLHLSNNFDSYTSGEVTIHPSAVLAPGVILQAAVNSKMIIG
                     PGVCIGMGSILQVSEGTLEVEAGANLGAGFLMVGKGKIGANACVGSATTVFNCSIEPGK
                     VIPPGSILGDTSRQIEQTQQLESSTNNGSETSHEEQPEAENSLDADEETVMSSTTISAT
                     TYWKFKHQSTSSSESSPTSSSQPPPVEEKTKATNSIPQKPKSSQPPTESPNSFGNQIYG
                     QLSINRLLVTLFPHRQSLNDSISDDHSE"
     gene            complement(23653..25323)
                     /locus_tag="IQ233_RS04545"
                     /old_locus_tag="IQ233_04545"
     CDS             complement(23653..25323)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006194888.1"
                     /locus_tag="IQ233_RS04545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04545"
                     /product="ribulose bisphosphate carboxylase small subunit"
                     /protein_id="WP_193997688.1"
                     /transl_table=11
                     /translation="MVVRSTAAPPTPWSRNLAEPKIHESAFVHPASNIIGDVRIGANVI
                     VAPGTSIRADEGTPFFIGENTNIQDGVVIHGLDQGRVIGDDQNKYSVWVGKNVSITHMA
                     LIHGPAYVGDDAFIGFRSTVFNARVGAGCVIMMHVLIKDVEIPPGKYVPSGSIITSQHQ
                     ADRLPNAEVEDQQFAHHVVGINQSLRTGYLCAADSKCIAPIRDEIAKSYTNTGITVLEL
                     ERSSEVSSNSLGAEIVEQVRYLLNQGFKIGTEHVDERRFRTGCWQSCQPIQPGSMGEAI
                     ASLESCLRDHSGEYVRLFGIDSGRRRVLETIIQRPDGVVSAIKSSAYTATSNGNGNGNG
                     RYSSNGNGHVASSGALSSETIDQIRGLLSSGYKIGTEHVDERRFRTGSWTSCKPIESTS
                     INEVIAALEECIELHQGEYVRLIGIDANAKRRVLESIIQRPNGQVTPSDPKKSFSRASS
                     GTATATATATSTKLSSEVVDQIRQILAGGHKVSAEHVDQRRFRTGSWSSCGQIDTRSDR
                     EAIAVLEGYLAEYPEEYVRLIGIDTKAKRRVLETIIQRP"
     gene            complement(25424..25726)
                     /locus_tag="IQ233_RS04550"
                     /old_locus_tag="IQ233_04550"
     CDS             complement(25424..25726)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017747341.1"
                     /locus_tag="IQ233_RS04550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04550"
                     /product="EutN/CcmL family microcompartment protein"
                     /protein_id="WP_089092369.1"
                     /transl_table=11
                     /translation="MQIAKVRGTVVGTQKDPSLRGVKLLLLQLVDEEGNLLPSYEVAAD
                     TVGAGADEWVLVTRGSAARQILGNEQRPLDAAVVAIIDTIHLENRLMYSKKEQYR"
     gene            complement(25733..26077)
                     /locus_tag="IQ233_RS04555"
                     /old_locus_tag="IQ233_04555"
     CDS             complement(25733..26077)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019494518.1"
                     /locus_tag="IQ233_RS04555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04555"
                     /product="carbon dioxide-concentrating mechanism protein
                     CcmK"
                     /protein_id="WP_006194886.1"
                     /transl_table=11
                     /translation="MSIAVGMVETLGFPAVVEAADAMVKAARVTLVGYEKIGSGRVTVI
                     VRGDVSEVQASVGAGVESVKRVHGGEVLSTHIIARPHENLEYVLPIRYTEDVEQFRENV
                     NAIRPFGRRP"
     gene            complement(26171..26479)
                     /locus_tag="IQ233_RS04560"
                     /old_locus_tag="IQ233_04560"
     CDS             complement(26171..26479)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006194885.1"
                     /locus_tag="IQ233_RS04560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ233_04560"
                     /product="carbon dioxide-concentrating mechanism protein
                     CcmK"
                     /protein_id="WP_006194885.1"
                     /transl_table=11
                     /translation="MPIAVGMIETKGFPAVVEAADAMVKAARVTLVGYEKIGSARVTVI
                     VRGDVSEVQASVSAGVEAARRVNGGEVLSTHIIARPHENLEYVLPIRYTEAVEQFRT"
ORIGIN
        1 gccaacaact agtacaccaa ttgggtggtt tggctttggt ggacattcaa gcgatcgcac
       61 cttgggagcg tgttgtggat ttgcaatttg ctcgtcgtcc tggagaagag gcattatacc
      121 atatatatgt ggaagtgatg ggcaaatata gcaacgccat cctcaccgat gccagcaaga
      181 tgattatcac agccgcccat caagttggtc agcatcagtc tagcgtccgt cccatccaaa
      241 ccggacagtc ttatgaaacc ccaccaaaac taactggccc tgttcccagt ttgagtgaaa
      301 ccccagagcg ctggcaagaa cgggtaagct tagtcccagg agcaatcaag cgtcagttat
      361 taaaaagtta tagcggcttg agttcggcac ttgtagagtc tatggtaatt gcagcagatt
      421 tagccccaga aactaccaca gatcagctca aagctgaaga ctgggaaaaa ctatttacaa
      481 gatggcaaga atggctccaa gctttggagt taagtaaatt tcaaccagct tggacagcaa
      541 atggttatac cgtcatgggt tggggcgcag tagcaccaga aaaagacatc caaaccttag
      601 ttaacaggta ttacactgac gaatcaaatc agcaggtgtt tgctcagtta cggcatcaat
      661 tgaaccagaa attacataat gttttagtaa aattacgtaa taaagcgcaa accttttcgg
      721 aacgcttgca gcaatcagat caagctgatg aataccgggc taaagctgat ttgttgatgt
      781 ctaacctgca aaaatggcaa ccagggatga aggaaattat cctacctgat tttgagacag
      841 atcagccaat tgcgatcgcg ctccaaccag ataaaaacgc tgtccaaaat gctcaacgcc
      901 tctataaaca gcaccaaaaa ctcaaacgcg ctcgtgctgc tgtggaaccg ttacttttgg
      961 atgtaaaatc agaaattagc tatttagaac aggtagaagc tgcgatcgct cagatagaaa
     1021 actaccaaac agcagcagat ttacaagctc tagaagaaat ccgcgacgag ttaattggac
     1081 aaaaatattt agaagatcca ggataccgca gccgcagtgc caacgaaaca gccgccacaa
     1141 actttcatcg ttaccgtacc cctaacaact ttgaagtctt aatcggtcgg aataatcgcc
     1201 aaaatgatca cttgagcttt cgtgtagcgg gagattatga tttgtggttc catgctcaag
     1261 aaattcctgg aagtcatctg ttactgcgtt tagaacctgg tacagttcca gaagccgcag
     1321 atttacaatt tgtggctaat ctcgccgcct actacagtcg cgcgcgtcag agtgaacaag
     1381 taccagtcgt ttatactcag cccaagcacg tttacaaacc taaaggagcc aagccaggta
     1441 ttgctattta caagcaagag cgtatcctct ggggacagcc gcaattagtc attggtcatt
     1501 agtcattcgg ctctaccaaa aaactggggt tagagccttg ccacttcgac aggctcagtg
     1561 catagccttt gtttcaatgt gggagcgaaa tcacgggttc ccaagattca aaaaatctgg
     1621 gcgaatgcgg tctttttctt tcccgcaatt agggacaaat ccattaaata atgggtgcgt
     1681 gagattgcct gttattggtg cggtcaaagt ccgtcaatca cgctcaattc cagatggggg
     1741 agtaatcaag caagcccgtg tagttaaacg tgtttctggg tggtatgtca tgctaaccgt
     1801 tcaatgggat gtaactgtac catcacccat gccacacggg gaagcagtag gaattgatgt
     1861 tgggctaacc agttttgttg ccacttctaa cgggctttta gtcaaacgtc cgaggttttt
     1921 tgtggatgcc gaacgcaagc ttaaattgct gcaacaacgc gtctctagaa aacgtttagg
     1981 ctcgaataat tggaaaaaag cacagaagaa agttgcttca ttgcatgagt acgttgctaa
     2041 ttgtcgtaaa gactggcata gaaagttgtc tcaccaaatc tgtaatgatg cagggatggt
     2101 gtttgttgag gatttaaatt tagttggttt gtcccgtgga atgttgggta aacattgcct
     2161 ggatgcgggt ttcgggcaat tctttaacat tctcgaacaa acttgtttta aacgtgatgc
     2221 ctattttcaa aaagtagatg cacggaaaac aagccaaatc tgtcccaact gtggaattga
     2281 gacaggaaag aaagaacttt ctgaacgtac tcatgtttgt tcaaattgcg gctatacgac
     2341 tgatagggat gtggcggccg ctcaagtagt tctagttaga ggacttgcag ccgtagggca
     2401 tacggtcaag atgcttgcag agggtaaatt cattggaatc cccgtgaagc aagaatcttc
     2461 gcacttatag ggcggagagt gtcaactcac ggtagtttaa atttattctc aaagatagag
     2521 gctagttttc ttcgggcata tctttttttt atttattttt ataaaaaaac tgtgtgaact
     2581 gttacaatat tgttaagaaa atttgcccgt tggttttggg aacgcgcaat ttaattttca
     2641 cctctaatga gaagacaacg cgcatattcg aggccagctg tgcaatgctg gtcttttttg
     2701 tttcttgtaa aaaagagaag acgcaaaaaa tgatttttta cgtctcctgg ggaaattttg
     2761 tgatatctag aaactaaatc tagttctgag cgcaccaatc acaacatcat cgttgtcatt
     2821 gttatgatcc ggggatgtca accagatgac accaggggta atggtaatgt tgtcagtcag
     2881 ctgatactgg tagaaagcct caaggtgata ggaggtatct ctatctctat ccacaccggg
     2941 gatgttggaa ctggtgactc taggttctac accagcgata atcccagcta gattacctct
     3001 tttacccaag tcaggaaagc ccagggtaac ggcataattc caaatttcag cttctccgcg
     3061 atcgcctgtc aaggcgcggc tgttggtgta tcctgcccaa cctcctaaga ccagtttttc
     3121 actgataccg atggatgctt gaacaccgta ggaatcgctg gagaaggctg catcgttttg
     3181 taatacattt tggaatgtgg cggcattgct acccgtaagt agtggctgtt tgtaggagtt
     3241 gatataagtt aaaccgagcg caatgcgatc gcttggtctg agtgtcagct gtgccaatgc
     3301 accgtaagca ccatcaaaca aaccattctt aggtgagggg ttattagctg taccacttaa
     3361 ataccctaaa ctgagtgata ggctatcacc gaactgttgg gttactccca aacccgcacc
     3421 acctatctgg ttataaattg ggttgcgcgt accaaaggta gacaaagccc cactactacc
     3481 atcaccgtca aatagattaa ctgtactagt gatgtcatct gctgcaccgg cattggcgat
     3541 cgcgatgacc tgtgtttttt cacccagggg aaatttgtaa aacaatgcat ctatcgccgc
     3601 attggtagta ccatccgcac cagcaaaaaa taagttcccc tctggtgtcc caatgttagg
     3661 tcctaaaata ttattagctt ggattctcgt aaacagggta tctctccccg taaaactggt
     3721 gacaaattga atccgtgtgc gcgctcccag agttgtatta ttgtctgtga tttcttggtt
     3781 attaactctg tcaccgccca aaacatcact cataactgcg acgacttccc cttgcagttt
     3841 ggtggtagtg gaaaactgat tcgcttccaa ttccgatgtg cgtgcttcta gtgaatccac
     3901 gcgaccccgt aatgttgcca attctgcgga aaattcctct tgcagtcttt gtaacgtgcc
     3961 taaatcttgt tgtgtcactg catcgctagt agcagtagca atgagttcat taacccgatc
     4021 tagacaagca ttcaaaccag ccgcgaattc atatcgagtc aacgcccgat taccccgata
     4081 agtgctattg ggataacctg ctatacaacc gtaacgttct accaaagatt gcaacgcttg
     4141 aaaagcccaa tcagtaggtt gcacatccga taactgagaa acggaggtaa tttgcgccat
     4201 tacctgatct tctgtgaggt tctcagtttt tatttcagaa ttatttatta ccgatgtcgt
     4261 gggtatttct cctgcataga cggtagcacc aaaaaatagc atagtaccgc caaataatgg
     4321 actaaccagt aggtatttcc agaattctcg cattttcttc ctcacactca ttgatggttg
     4381 attgcactca caccaggcgt tttcgcgaat accttcgcta aaaaagtata ttcagaatat
     4441 taacaggagt ttaagaattt gcctaacatt actagtcaaa ttctgatttt tcttactttc
     4501 tggagaaatg ttaaaaggta gtatcttctg aaacaaacat taatttcgtt cttttttata
     4561 caaaatatat tttaccatat tgtgtgagaa tgagacttat tctataatat aaaacgaatt
     4621 cattctcaag agaaaatttg acaaaagtca agcaattatt actgtagagg ggaaaaagcg
     4681 tgatttggaa tcgtttaaga cctagaacag gcaaacaaac cagaggtatc ctgcctttaa
     4741 tggctttcct cacgttgtca gtcgctgttg gctgtaacca atcaaacaca gatatcggag
     4801 aaacttcaga acaaacaccc ccagcacagg aagcagcagc gactccaggc gcgaccgaaa
     4861 aaattaaagt tgtcgccaca tttttgccca cctatttgtt taccaaggct gtggctggag
     4921 acgcagcaga tgtatcaatt cttgtgccac cgactacgga agtgcatgat taccaatcaa
     4981 caccggataa tgttaaagcg atttctacag ccagtatctt agtaaaaaat ggtttgggat
     5041 tagaggaatt tctcgacaac actgtaaaaa atgccgaaaa tcctaaattg gttgaaattg
     5101 atgcgagtaa aggtattaaa atcttggata aaatttcgct agttgatgaa acagtcacag
     5161 aagacggaca tgatcatgat caaggaaatc ctcacgtttg gttagatcca gttttagtaa
     5221 aacagcaggt aacaaatatt cgagatggat taagtgctgc tgatcctgct aataaagcta
     5281 cttatgaagc caatactgcc gcttatattc aagaattaaa caatttaaat caagaatttc
     5341 agcaaacttt gcaaaaaact cctaactgca cctttatcac ctttcatgat gcctttccat
     5401 atttagctca acgctataat gtcaaacaag ttgctgtggt gcaacttcct gaagaccaac
     5461 tttccccagc agatgtgcag aaagctgtca aagctgtgaa aaattataac gctaaagctt
     5521 tatttagcga accaggggta gataataaat tattaaccag tcttgcccaa gatttgaatg
     5581 taactgtgcg taacttggat tctatagaaa ctactgccgg cgatacaaat ccgcagtatt
     5641 atttccaagc catgaaaact aacttgcaaa ccctggaggc tgggtgtaaa taattggatc
     5701 tccaagatag cgatacctga tgatcgtttg tcttgatgtc atgagcaatt aataattacc
     5761 cataatccag gactaatgac atctcccatt ttaaaagtcg aaggattaaa tgtatatcaa
     5821 ggcagttatt tagctgtacg agatgtagcc tttgaattgc taccaggaac agatacagct
     5881 atcgttggcc ccaatggtgc ggggaaaagt actttggtga aagcgatttt agatttactt
     5941 ccccatagtg ctggcaaaat tgaaatcttt ggtcgtccaa ttagcaagtt gggaaatttg
     6001 cgtcatcgat tgggttatat gccacaaaat ttcatctttg accgcagttt tccgatttct
     6061 gtcagcgaat tagtcggact gggatgggcg aatgaaagta aacagcagaa ttcatttttt
     6121 tcccaactgt ggaaaaaaga taggagaaaa tcagtagcca tagcagaggc tttgcggcga
     6181 actgatgctt atcatctcaa gcaccaagcg attggaactc ttagcggtgg tcaactgaag
     6241 cgggtattgc tggcttattg tttagtcatt cctcgccaac tcttggtttt agatgaagct
     6301 tttgctggcg ttgatatcca aggtacaaca gatttttacg ctttgttaaa tgaattaaag
     6361 cgcgaagaag gttggacagt gttgcaggtt tcccatgata ttgacatggt tagccgtcat
     6421 tgcgatcgcg ttctttgtct caatcaaact gttgtttgca ctggtcaacc cgaaattgcc
     6481 ctttcaccgc aaaatctgtt agcaacctat ggcctgggat tcagtcctta caagcataac
     6541 cattaacatt ttcaatcata gcgttgctca caattttgga taactgacct tttttgaatt
     6601 caaaattcaa aattcaaaat gcaaaatgaa gaagaaataa agtttttggc gttgctgaac
     6661 taaagtatga aatgccaaaa tcaccttgat ttttcttcct acctttgcgc ctttgcgcct
     6721 ttgcgtgaga ctaattcata tttgaaatca gcaacgccaa gttttttatt cagcaggttc
     6781 atccaaatgt tcagcaacag cctgataaag atgaaaaata tgattatcgt ggagatgata
     6841 gaacacatta cgtccttgct tgcgatagcc aaccaatcgc ataactcgca aatttcgcag
     6901 ttgatgggaa acagcagatt cactcatttt tagtaatgcg gccaaatcac ttacacacag
     6961 ttctttatta gccaaaaaag aaaggattcg caggcgattg ggatctccta aaaagctaaa
     7021 aaattctgcc atccgttgag ctttttcagt actaagaact tgtcctgcta aatgttgcac
     7081 aatatgaata tctatagtaa tctatcttaa attatactca agattataca gttttaaatt
     7141 cccatctaat tataacaatt gtatttgatt gacattctga taattttgcc tgtgagcagt
     7201 ctaataaggc tcaaaataat atatagatcg tacttatgta tttatgctct gtttgccaga
     7261 tcaacttgct agcgaatcgc catgaatttt gactttgtaa atttgttaca atttcccttc
     7321 atgcagcgtg cgatcgccgg cgctgtgtta atgggaatcc tggggggatt actaggtact
     7381 tttgctacat tgcgccaact atcctttttc agccatgctg tgggtcatgc agcattaatc
     7441 ggcgtagtct taggtgtatt gctacagtta aacccaactt ggatgctgtt gccttttacc
     7501 ttagtctttg gggtagttgt cctctacttg atcgacaaaa ccgatttagc gagcgatagc
     7561 gttctgagta tagtgctatc aggagcatta ggtattggcg taatcctgac tagcttcgtt
     7621 ccgggttatc gtggcaattt aatgagagta ttgttcggtg atattctggc gatcgacaat
     7681 acagatttaa ttttgacatt aattttgctg atcgccagta gcatattttt attttccacc
     7741 ctgcaacagc aaattttatt gaccattaac cccgatgtcg cccaagtaca aggtgttcca
     7801 gttcaactat atcgctatgg ctttgtcatt ttactttccc tggctgttgc cgtagcgatt
     7861 acagccgtcg gtgttttgct agtcaatgcc tttttggtaa ttcccgcttc caccgccaag
     7921 ctgatgagtc atcatttcaa ccgctttctg gtcttatcaa tcatcgtcgg ttcgaccaca
     7981 agcctgactg gtattatggt ttcgggtatt tttaacctgc catcaggccc tagtattgtg
     8041 ctggtgcagt ttttgttctt tgtcgctgtt ttcttggcgg tgaagttgaa gttcaaagca
     8101 gcttaaactt tttttgttca acctattgcc aagcaattat tgttgtgcta catttattaa
     8161 tcgtgggtca aataaataca cagcgccggg atagctcagt tggtagagca gaggactgaa
     8221 aatcctcgtg tcaccggttc aagtccggtt cctggcatat aattaaatag acaaaaacct
     8281 tgatttttca tggtatccaa atgactccta ctggaattta ttaattttct agtaggagtt
     8341 tttgcatttt tggttcagtc ggtgttgaat tggcatttct tttttatttt accctttctc
     8401 ccaagatccc aaatgggttc tatacatact caactgttgc caagatgccc agactcatag
     8461 agaatcatta gatacaaatt gatcctctca ttgtccaaag ctactagagg caactgctac
     8521 aaactgccat gttcaaactg atagatgtct tctgggctta tattctcatc gctatattaa
     8581 tcctcgtggg gcggttaatc agacagcgcc tgggaatatt gcgatcgctc tacataccca
     8641 gttccatagt tgctggtatt attgccttac ttctgggtaa aagtgctttg ggtgcaattg
     8701 tccaagcaat aaatcccaaa tctccccttg ttcaaggcat atttaccgaa aatgtccagg
     8761 cggtttggtc gcagtctcct ggtatcttta ttaatattgt ttttgctacc ctgtttctgg
     8821 gtcaatatgt tcctactttg cagcaatttt ggactaaagc tgccccacaa gtggcttttg
     8881 gtcaagcgat cgcctggggt caatacgtag taggattaat actagcaatc accatattga
     8941 caccagtttt tggtttaccg cccatagtcg cttgtttaat tgaagtcgcc tttgaagggg
     9001 gacacgggac atcagccggg atggcggcaa cttttacaga attgggtttt accgccgggc
     9061 ctgatttatc tttagcttta gccacagtag ggctggtttc tggagtgatt tccgggacaa
     9121 ttttgatcca ctggggacgc agaactggac gtatcaaagt cagccgcgaa cctttagata
     9181 atctggaaaa tacagagaac gaactaccag aagaagaacc aagtgtcaca attgcgagaa
     9241 aaaatttatt ccgcgactta ctaattgatc cattatcact caacttcggt tttgtcggat
     9301 tagcgatcac tttcggctgg ctaattttag aagctttgcg ctttattgaa tcaatcacct
     9361 ggggtagagg tggagtggaa ctgatttctt acgtaccgct attccccatc gccctgattg
     9421 ggggaatgat tgtgcagtat atacttatgc gtaccagacg cacctattta attagtcgtc
     9481 ccctgatgga aaacattggt ggactggcgt tagatattac aattgtcacc gccctagcaa
     9541 gtatttccct ctctgtactg ggagataatc ttgctccttt cctgatttta tccattgctg
     9601 gtattgcttg gaatgtctgt gcctttatat ttttaggccc ccatctccta cctttttact
     9661 ggtttgaacg tggtattggt gatctgggac aatcgatggg tgtgacttcc acgggattat
     9721 tgctgttgcg aatggtagac ccagataacc gttccggtgc gtttgagagt tttgcttata
     9781 aacaattgct gtttgaacct attgtgggtg gaggcttatt taccgccgcc gcaccgcttt
     9841 taattgctaa ttttggctcc ataccaattt tgctattaac atcatttatc ctggcatttt
     9901 ggctgatatt cggtttctat aactgtaagc aactacgtaa gcaaagcgat tgaagtagtg
     9961 tcataatttt agacaaataa ctgtcgtgta tttaaagata atgatccaac tttcattaga
    10021 ctgtaaaata tcgcctgcac cgaatgtatt agctcaagac ttggcagggg agtcagtttt
    10081 acttaacctg caaactgagg agtattttgg cttggatgat gtgggaactc ggatttggca
    10141 aaccttgaca gataaagatt ctatccagtc tgctatagat gtattggtaa ctgagtatgg
    10201 cgtagagtca aaacagttac agcaggatgt agaaaatctc attgaagaat tattagccaa
    10261 tggactggtt gaagttagcg gtacgtaaat tacgcagttt ttggggactg gatagaaatt
    10321 cccgctggct gttattgcaa gcacttctgt ttttccccct agtgactcta tccttaaaat
    10381 ttgggggatt aaagcgcacg caatctgatt tagtacgaat gttaccacct ggaaaaatag
    10441 tgcttccaga tagcgaactg acaagtcagc gcttacgcga tcgctcctgt aaaattatca
    10501 agacaattag catggtgcag ttagcagcca gatattgtca accttgggca aaatgtctgc
    10561 aaaagtccct agtgctgtgg ggtttgttgc gtcaccaagg aattaacagc gaattgcgga
    10621 ttggggtaaa aagggacgca gagagttttg aggctcatgc ttgggtggag tatgaaggtt
    10681 ttgtcctcaa tgatactcaa aatgtgcgcg atcgctttgc catgtttgat cgtcccattg
    10741 aagttaattt tcccagtaga gagagttgat gtctgtccaa actgcactac aatttatcca
    10801 acaactacgg atggatgaag ggctaaaaag ccgactttta gctctcaaca accaccctga
    10861 tttagcaagt tttgtcaaac ttggcgctga attcaatctc accttcacag ttgaagaact
    10921 gaaaacagca cacaaacacg attgggggat gcgctggtta ctccataact ctagattaga
    10981 agacaaccgg caatgatttc aaaccacgtc ccataaaaga atcctcccat tctaaagatt
    11041 ccgttgctaa tgataaccca ggtaaacggc tcactattat atttacggca atttctgtta
    11101 ctaatttagc taagtgtatc ccgatacaac tatgaattcc ttgaccaaac gaaagatagg
    11161 gattaggttt gcgtctaata tcaaattggt tgggattggg gaaatgggcg ggatctcgat
    11221 tggcagcccc gataatacaa tgaactatct ctccctgacg aattgtctga tttgatagtt
    11281 cgatatcaga tagtgttgta cgtggaatac tatgaactga actttcatag cgcagcactt
    11341 cagcaatagt tgtttctatt aaggatgggt cagcttgtag taaatgtaac tgttcgggat
    11401 gattcagtaa tgtgagtata ctgttgccaa ttaaattctc agttgtggag tgaccggccg
    11461 caaatattaa gatgcaattt gctaagagtt cttctgcact caattgaccc tcagcttctg
    11521 cttgaattag agtgctaatg aggttatctt gcggctgcga acaagtacgg ctttgagcaa
    11581 tccaactttt gaagtattcc gctaaaccag cgatcgccag caaaccttgc tcattagcaa
    11641 tcggggtcac gtccaaatcc aaagataaag ataggctcac agaccactgt ttaaattgcg
    11701 gatgccattg ttgtggtgga atccccaata ttttacagtt taagccgagg gtgagcggat
    11761 aagctaaatc gttaataata tccattttcc ccaagtcttg aacccgatca atcaggtcgt
    11821 caacagttgt ctgaatgtgc gatcgcaatg cttgaatatg cgattgagtg aaggcactac
    11881 gcaacaaggg acgaattctg gtgtgggtgg gtggattttg tcgcaccaac cacaacttca
    11941 ttaatctttg actttcctga cgcagaccga gaaagttgtt tatgggcgct ggggttcctg
    12001 tctctaggct aacgatactt ttctgtgcat gaccaaagat aggatttttc agaacctctg
    12061 aaatatcagc atagcgcgtc agcacccaat catttccctc agaacgatag taaatggggt
    12121 ggtgcgtccg caggtaatca taggtgggat agcgattagc ccggaactct ggcgatcgcg
    12181 gattaaatgg taaaggtgga gctatacttt cactttgact ttgcatattc atctctcaat
    12241 ctgctacaat atctaaaacc cgcgcaccgg gagtaatgta gggataaaaa ttccttatag
    12301 tttgctttaa acccgtttct aaatcttccg aatcgcgaaa atacccaaag tggtactgta
    12361 attcctcacc aaaattcctc accaataatc tgtttccatt cctgaataga ttccccagaa
    12421 taaaaactat ctaaatcaaa cttgacctca gaatttacat tcatattttg cttgctcccg
    12481 ataaccattg atgttgaaac caaagatatg ccttagctac aagaggactt tgtgattgag
    12541 aaacaatttt aatgtggctc aagcggcgtt caaagacagt gaagcgttcc ctctgttgta
    12601 aaacagaagc agcaatcaaa ttatgcggcc aaggtgctgg agaattaagg ggattgattt
    12661 gaccaggcca gtttaacaat gcctctcgct tttgcacttc gcacaatcct cgttcgacta
    12721 aataatcaag gaaaatagcc cagcgagatt ctgagtcagg ttgattgagg aaaatacatt
    12781 ctaagccaat ctgtgggtaa atttgatcac ctacatccag acaaactgtg atccggtcaa
    12841 ctaaagcaaa caattcttcc atcaattctg ccactttaac tgtgtccccc tgccaaccaa
    12901 tctgttgcaa atagggaatc agaaaatggg gttgtaaacg tttgacattg actcgcaaag
    12961 ccggtgaatt tcgggataac atcacgccga tgtgactgac aaatgcacca tcaggacaag
    13021 cagcaaagca gcgatagaga ttatcttccc acccagacca tcctaaatca ccgagcagta
    13081 aattgagaga ttgtgccgca attccatagg tttcaactga tggcgatact tcttggggca
    13141 aaccgaagaa aatagccggg agaggcagaa caaatgatga tatcaaatct ggttgaatac
    13201 ttacgaaacc ttgcttaatc tcccctcctc cctggctgtg agagattggc agtaggtttc
    13261 ccagattttg gtcgccaaac ccttgcgtta tctcccctcc tcgctggcgg ggaggggttg
    13321 ggggtggggt tccataattt ttatcaacat caaactccaa ccaaatctcc ggaattgact
    13381 ccagacatga ccgccattca gccaaaaaat cccgtaatcg caaccattcc ggatatgctg
    13441 tttcctcaca ggtggaaata gccacttcca tgaactcttg caacaaatcc aattcttgtt
    13501 cattgcagac aatgcactgc tgcaaatcta cctgggtagc attagcacta agacgacatt
    13561 caaaaccacc ttgaaaaatc ggtgctaaat tacccgccaa tgcttttaaa cttaatgctg
    13621 catcttgacc aattaaatgt tctaaagacg gtgattttat ccccgtcccc aataaaacat
    13681 caagggattc tactaaagtt gagtacattg ctctaacaac gtgatattac ccacatcatt
    13741 gacaatggca tcacacaatt gaggcaatgc tgtcaaacta tcgctgcgag agaccttccg
    13801 aatgggtaca gtcattgcta cgcgactaag accagcaaat tcctgtgctt gtttatccat
    13861 acctaatttt aaatggctga ccgaacggtg agtcatcaaa gtcatcaccg cagttgctgg
    13921 agaaatagtc tcaatcatcg gggctgccaa ttcaggatga cgttttccca gcacatagat
    13981 agctgccaat ggtagggggt cactgtgaaa cttccacaca gtttcactgc tgttgccaac
    14041 taactctaca aaacgtttct cagaaaagct gaaaatcctt tccaaatcag attctgaccc
    14101 gtatagggca tgaattgttt gaggccaaag ccgtagacgc ggatatcccg gctgtacaaa
    14161 ccaatgttgc tcgtcgtcct tgagaactgc aatatcatcc gagagaatag agtatccttc
    14221 cttagccaga gccgccgccg tcgttgattt ccccgcccct gattcaccca caatagcaac
    14281 agcgtgctga tcaattttca ccacacaagc atgaaggcaa agtgttcccc gtaaccgcaa
    14341 agcacagcct aaaacttgcc ccaacaacag cgcattcact tcttctagta gcgcacaagt
    14401 ccaatttgcc gagatgtgac tgcctccagc atcaagatag aaatcaagtt gtccgtcacc
    14461 gcgaaaccag agatggaaat aagtgccatc ggctttagat agcacattca gaccagatga
    14521 aatagtctct atttctgctg acgacggttg cgattctcca ttcaaatcga cccaaacatc
    14581 gacgggggca tcactctttg cagcgattaa acccgtcaga ggttgattta cctgtagcgt
    14641 taagccataa actttatatc taaaagattc actcaatttc atcaaaaata cttacttgta
    14701 ggaggcaaaa taggttagtt attttgaccc aatatatgga tatttactga gttttgttag
    14761 ccgattgggt gcaatagaaa tcgacagaat ttaaatatgc gttatccaga acccttgtag
    14821 agacgtttca tgaaacgtct ctcaattctt tttcaccaga tgtctaagag gatgtttgaa
    14881 aagtccgaga aggtataatt tgaccttccg attgggctta attaagacga taaatcaagg
    14941 ttttagccct taccgagata cttagttgtg ccaaaagtga ggtcaagcga cccttttcaa
    15001 acaacctcta atggcagttt atcaaaaaga tggtgttggc gaatgtttcg ttaaatttaa
    15061 catttgggaa aatcaacctt gatggtaatg ttgagtttcg ctacactctg cccaatctcc
    15121 accaaaataa agtgtttagg tatgaagata tgatttcgcc aacagggtct tagacgtttt
    15181 aattacgatg catatacatt agggaacgca ctaccaccac catcgatacc atctatgttg
    15241 aaagtgggac tagccagcgt cagattctta atattgccaa attttcgcag ttcgggggta
    15301 tggtatggct tgtgattcgc agaattagat tggtttgtag atatttgaga catcgtttgg
    15361 ctcctcaatt ttagcttata gttataaaat cggtcggtta tttacctcta aacaaggctt
    15421 atggcgcagc cagtatgcca gttgcatagt tggaattacc tgattatatt taataggtgt
    15481 aagttttaca acattttgta gttttggcaa taggcgttca gctttcacat agggtgtgag
    15541 agccgaagtg tttactaatt ctaccatcca gggctggata ccttgctgct gcacccagtt
    15601 gtaatgagca aaacctctca gaggtgtttt gggtcgctgt cgcacggaat cgggcaatat
    15661 acctggcata gcttcccgga gcaggaattt attttcaaac caaggtttcg gcggcacaga
    15721 cagcaggaat aataccaaag gcaaatcgaa aaatggaaag cgcaccttca cgggaaaacc
    15781 actaaagccc ggatctgacc aagcaaatat attagaccat aggggagcag tcgccatccc
    15841 gtagcggtct ctctgtggtg aaccagttaa tctgtcttgc agtcgggctt ccaattgcat
    15901 ttgttcagca aaatctgggt taaaccagtc aggtaactcc ctctttttct gtcctggctg
    15961 cttgattccc agcaactgac gcaaccgtgt acccaacccc aactgacggc gcagagagcg
    16021 gatataaccc aagggattta gcatgaaatc ctgattatgt accgaattat actgctcatt
    16081 agggactggt tcaaatgccg gatctccccc aaacccagct aacaataccc gactataccc
    16141 agatatccgc cgtgtaattt ccacttcagc cacttgggtg ggaattagta agggttcggg
    16201 atacaggtat tctgggtctt ggggaggagc ctgcgggatg taatcttccg ccactaaata
    16261 ctcaagggga aaacccgcca tctcagcaac ttgtgtagca tagtcccctt catcgtcggt
    16321 aatcagttgt ttataaatta ttgtataagc ccgaaaatcc acaggagaac ccgttgcttt
    16381 cattaattta taggcagtag cagcgatact ggtggagtcc atacccccac tcaaatgagt
    16441 cccagcacta ttagttcgta atcggtcggc aattgaccgt tcaaacaatt cctgaaactg
    16501 ctcaatatag tcctccgggc gctgataatt caggcgttcc accgcttccg gtaactgcca
    16561 gtaacgccgg atgcgtactc taccttccga acaaattagg gtgtgggcag ggggtaactt
    16621 ttggatatcg gcaaaggtag tagtggcgac atccagattc atgctaaata gcagaaaatc
    16681 ggctattgac gcttcattca gcctatctga tacctctgga tgcaagcgaa tggggttgat
    16741 atgattgctg aaaatcaggc tgttgcccat ttctgcatag taaaaaggca caataccaaa
    16801 atgatccctg gcgcagaata agcgttgctg gcggctatcc caaatagcaa aggcaaaatc
    16861 cccactcagt cgttctaagc aagcatctcc ccacacttgg taggtatata aaactaaatt
    16921 aacatctggt gcgtcattat ttacactaca tccagaggca cgcaaccgct caattaactc
    16981 cctgcgccta tctaagcgaa tatcccctgt aatccaaaga ttaccatcca aactgtgggg
    17041 ttggcgttcc ttttctgatt cccaagtagt ccgcaacaaa gcgtgaccaa aaccaataga
    17101 accgttactc caggtatcct gggcatcggg tgcttgaggt gtcatcaaat cagtcatttg
    17161 ctgtaacagc gctgggtcga tgggttgacc attactgttg aaaataccaa taaaaccgct
    17221 cataaaatca aacagccttg tttatgataa gttcaatatg atacattgta ttgctaacac
    17281 aattagaaac ttctaattac aaaataaaac ttctgggcga atataatttg ctactaaata
    17341 agtatgacgc gtagcggctg accgtaggga agtttaccga cctggactaa tgaagaatta
    17401 aagttttaac ccgcgccggc gggttttgtc tgtatagccg cgacttctag tcgccgaggc
    17461 tcataataaa ttaaacttta caaacatcct ctcagacagc taattttttc gataaaaaca
    17521 acagaaaaac catcgcacgt aacagtttaa aatttgaatg tctctgataa aacttatcca
    17581 tactctccga agagcaatcc aattagtttg gcaaagctct cccctatgga caattttcag
    17641 tatcatattt ttattcatcc aaggaatatt acccctactt tctctttacc tggtgaagtt
    17701 gatagtagat accctgactg agaatattgc gactcccaac cctctccaga cttttaagca
    17761 attattactt ttgatattaa tatccggggt tgtagcttta tttcaaaata tcgctcagtc
    17821 actttctgga ttaacaaaca cagcgcaatc tcagatagta atagaccata ttcatgatca
    17881 aatccatgct cagtccatag cagcagattt agaatattac gaaaattctc aatattacaa
    17941 cgctttacac cgcgctcaac aacaatcatc ccatattcca ccacagatcc tacaacatct
    18001 agtacagata gctcaaagtg cagtttcatt ggtagcaatg gccgccctac taatttcctt
    18061 acactgggca ataggaatta ttttattaat tacggctatt cccacattat tagtacgcat
    18121 gaagtatgca ggtaaaacat ataaccaaca aaaagtttta actagcaaag agcgagaagc
    18181 tggttacttt aactttatgc ttacttcttt acattatgcc aaggaaatgc gtttattagt
    18241 ccttggtaat ttatttcgcc gtcggtttca aaaactacga aagcaaattc gccaagaaaa
    18301 attgaattta gaaattcaac gttctctgaa acaaattatc gctcaaatag gtagtactct
    18361 ggtgattttt gccctatctg ctttcatcac ttaccagact cttctgggag ctattacatt
    18421 aggtagctta ataatgtatt accaagcctt tcaacgagga caagtatctt tgagtcagtt
    18481 acttagtagt ttagccggac tttatgaaaa tagtttattt ttaactaact tatttgaatt
    18541 tttagattta aagcctaatg tcaccgaacc accattaccc aaacccattc cttctgaatt
    18601 caaaacaggt atcgattttg atcatgtccg cttccattat cctcaaagta cacgacctgt
    18661 cctcgaagat ataaatttta acattgctcc tggagaaatt attgccttag taggggagaa
    18721 tggagtaggt aaaactactc tgattaaact actctgccga ctttacgatc caacagcagg
    18781 caatatcacc attgacggta tcaatatccg ggaattttca cccacagact tacgtcgaaa
    18841 aatcagtgtc attttccaag actatgtgca gtatcacctc acagccaaag aaaatatttg
    18901 gttaggtaat ctcgatattt tacctgagtc taaacaaatt gaaaatgcgg ctcgtgatgc
    18961 tggtgctgat gtagtgattt cccagttacc ccaaggttat gacactatgc tgggtaaatg
    19021 gtttgaagga ggagaagaat taagtattgg tcagtggcaa aaagtagctt tagcacgagc
    19081 gtttctccgt gatgcgccta tcatcatttt agatgaacca agtagtgctt tagatcctaa
    19141 agccgaagct gaaatttttg acaagtttcg tcaagttgtt aggggtaaaa tagcaatctt
    19201 aatcagtcat cggctttcta ctgtgaaaat ggctgataga atttttgtaa ttacagatgg
    19261 caaaattagc gaatgtggct ctcatgaaga gttaatacaa cacagaggaa cttatgcgcg
    19321 tttatttgaa actcaagcca aacattatag ataattattg ataactatga ctactttatt
    19381 acaaacaaat caaccccaga agaacaatcc aaattctcaa atatttcatc gacccgaaat
    19441 tcaactatta ctatattgtt ccagaacctg tatcaacgct gtcacagcag aaaaaattca
    19501 aaaattaagc gaacaagagt tagattggaa ttatttactg cgtatagctg ctcgtaacga
    19561 aataataccc ctactttatc aaagtctgaa gctgatatgt ccaaaagctg ttcctaagaa
    19621 tattctgcat caactccagc aatgtttcca agctaatgct tcccgaaata tgttcttgac
    19681 gacagaacta cttaagctgc tggatttatt tgctgctcag aatatctctg caattccttt
    19741 caaaggtcct gttttcggtc agtttgctta tggcagcttg atattaagaa atatatctga
    19801 cttagatatt ttagtcgaaa agcaggactt tctcagagcc aaagagttgc ttattcgtca
    19861 tggatatcaa cacaaatatt ttggcgaaca tgaagcagct tatgtccaag ctcaactaat
    19921 ccgagatgat ggtttggtgg gtgttgattt gcattatggc attactccca gggatttttt
    19981 gtttacactt gatacagaac ccttttggga acacttgact agcctatctc tggctggtaa
    20041 aaccgttcct aatctttctg ttagtgatgc cttgttagtt gcttgcgtac aaccaattaa
    20101 ggagaattgg aagtctttca aaaggatttg tgatattgcc gaactttgca aactttgtac
    20161 ggaaaaagat tggcaagttt tttttgagga aatgcagaaa ttgggcaatg aaaaaacttt
    20221 tctagtatct ttgattatgg ctcatcattt attagaaata tcccttccca aggaagtatc
    20281 tgaaaaaatt agggtacttc cttcattaaa atcaacgact ttagaaatct ctgagcaatt
    20341 tttcagcgag actccaaatg atagcgatct ttccataaac tggggaaaaa tccaactgct
    20401 aagaatgtcg ttatataata atcaaaatca aattaaatat cttgcctttg tggcttttaa
    20461 tattaatgaa aaagataaat taatgttgcc ctttcctttg ccaaaatatc tttatttttt
    20521 atattatcca ttacgtttat tcagattatt gctcacctat aaaatagggt taaaggacat
    20581 aaacctctaa acctcttcta ggttgagacc cgtagttttt tctcatcagg tttgagatga
    20641 gttataaccc accaacaggg gttaattcct tgctgaaatg ccgagaacta tttaattcgg
    20701 taatactgac aacccaggtc gctgggtttg gtctgtgtag ccgcgatttc tagtcgccaa
    20761 ggctagttgg aatatcctca agtttagggt aagcagaaaa accagtttcc tcagcaaact
    20821 tctttgttgc ctctaggaga tactcataat aggtccgagc aacaatagat aactgtttcc
    20881 ctggtggatg caccatatac caagtgcgct taataggaaa gtgttctaca tccaaaatgc
    20941 tgaactcaga agagtctggc attaaggtat gacgcgataa aacagaaatt cctaaaccac
    21001 ctgcgatcgc ttgtttaatt gcctcgttac tgcccaattc cagtttaact tttaccttca
    21061 caccatgttc ctcaaagagt tgttgcacag cgcggcgagt tcctgaaccc ggttccctca
    21121 taataaaagg ttcatttgtc aatcttccta tgggtatatt tttctctttt gctaagggat
    21181 gattaaccgg tgcaaacatt actaaggggt tgtctaaaaa tggctcatag ctgacatcta
    21241 gattttctgg gacttgactc ataatgtaca agtcatccat gttattgacc atccgttcca
    21301 agatgcgttc atggttcgtt acttgtaaag aaatttcaat tcctggataa agttgacaaa
    21361 atggccctaa taaacgaggg acaaaatact ttgctgttgt aatcacagcc aagcgtaatt
    21421 gcccttgttt taaacctttc aaatccgcca cagtcatctc aaactgggcg atagtttcaa
    21481 aaatctgccg acaagtagca aataattccc ttccggcttc tgtcaagaat agacgttttc
    21541 ccacctgctc aaataatggc aaccctaccg attttgtaag ttgtttaatt tgcatggaga
    21601 cagtgggttg agtcagaaat aattcctcag ccgcacgagt aaagctactg tgccgtgctg
    21661 ccgcctcaaa cactttcaac tggtgtagcg ttgcttggtt caagagtgat tctcctctaa
    21721 tagcgattta tatctataaa tctagtatca ctgaacactt gccaatgatg ccgaatcact
    21781 catacgaagt tgtgaatttt agtatagata aaactctatt aacgttatta aaagaaactt
    21841 gttttactta tggtaatcac aagttattat caaaacaaca agcaaagcgt cagatgcctt
    21901 ccaactaaag atgaatgttg aatgccgaaa tttaaatgat aattgccgac aatggatcat
    21961 ttattcttcg taattcatca ttcatccttc catatttctt cggtcacttc ttcggcaaac
    22021 tttgctggga tttgggataa atcaggtaac tgtagcactt ctatttcagc cacctgttct
    22081 tccacatcta caggtatatt caagggttca cggtgttcaa tccagcaact ggctaaaggc
    22141 aaagtattct ccatttcatc cagtggtcga ggaatcacca tgactgcgtt caattcccca
    22201 atgcgttctg cctcaaacat tcccgcttct acggccacag ctacattggc cacagtgcca
    22261 cgaataatgg ctgtacacaa acccgcacca attttttcat aagctgctaa atgaacatca
    22321 gccgctttga gcatagcatc acaagcaccc accatcgccg ggaagccccg cgtctcgact
    22381 aaaccaatgg ctaagttact taaactgctt tgattacctt cctccatcaa tttactcagg
    22441 cggctattga taggcaggac tatctccagg ttaggataag gccgaggaat taccaaacta
    22501 gaaaccaatt gaccaaattg ttcagcagtt tgaacaccag cttcaaccgc cagacggaca
    22561 tcggcaattc cacccctgat aatagctgta cattggccac taccgatttt ttcatacccc
    22621 actaagtgaa ccccagccga tttcagcatc atatctgctg tcccgactat ggcgggaaag
    22681 ctgctggtag agactaaacc taaagcagtg tttttcagac tatctcgacg gcgggatttc
    22741 cgaattgtgc taagagcgtg ttgattagat gtttccatgt gaattttcca agttactcac
    22801 gaaaccgaca actaacaatt aacacttact cagagtgatc gtcagaaatg gagtcattta
    22861 agctttgcct atggggaaat aatgtaacta ataatctatt tatacttaat tgtccataaa
    22921 tttgattccc gaaactatta ggcgattcag tgggaggctg actagatttt ggtttctggg
    22981 gaatggaatt agtagctttg gttttttctt ctacaggtgg aggctggctt gacgatgtag
    23041 gcgaagactc agaagaggaa gtagactggt gtttgaattt ccagtaagtc gttgctgaga
    23101 tagtagttga ggacatgact gtctcttcat ctgcatctaa actattttct gcttctggct
    23161 gttcttcatg actggtctca gatccattat tagtggatga ttccagttgt tgtgtttgct
    23221 caatttgccg actcgtgtct cccaaaattg agcctggggg aatgactttt cccggctcaa
    23281 tagaacagtt aaaaactgtg gttgctgaac ctacacaagc atttgcgcca attttgcctt
    23341 tgccaaccat caaaaaaccg gctcccaagt ttgctcctgc ttctacctct agggttcctt
    23401 cgctaacttg gagaattgac cccataccaa tacaaacccc tgggccgatg atcatcttgc
    23461 tgtttacagc cgcttgaagt atcactccag gtgcaagtac tgcgctagga tgaatagtca
    23521 cctcgccact cgtgtaagag tcgaagttgt tgctgaggtg cagtggcggc acagacatgg
    23581 aaattttaac ctcggaagcc ggaaaaatat gagtgttgag tggtgagtgg cgaagcctac
    23641 taacctctct atttaaggac gttggataat cgtctctaag actcggcgtt tggctttggt
    23701 gtcgatacca atcaaacgca catattcttc gggatattca gcgaggtatc cttccaagac
    23761 ggcgatcgct tctctgtcgg atctggtgtc aatttgacca cagctagacc aagaacctgt
    23821 acggaagcgt ctttggtcta cgtgttcagc actaacttta tgaccaccag ccaaaatttg
    23881 cctgatttgg tctaccactt ccgaactcaa tttggtactg gtagcggtgg cggtggctgt
    23941 agcagtgcca gaacttgctc tactaaagga ttttttggga tcagatgggg taacttggcc
    24001 gtttggtctt tggataatgc tttctaaaac ccgccgttta gcgttggcat caattccgat
    24061 taagcgcaca tattcgccct ggtgcaattc gatacattct tccaaggcag caatcacttc
    24121 atttatggaa gttgattcga tgggcttgca gctggtccaa gaaccagtcc ggaaacgccg
    24181 ctcatctacg tgttctgtac caattttata accgcttgag agcaaaccac gaatttggtc
    24241 tatggtttcg ctactcagtg cgccactgct ggcaacgtga ccattgccat tactactgta
    24301 acgaccatta ccattaccat taccattact agtagctgta taagcgctcg atttaatcgc
    24361 actcactaca ccatcagggc gttgaataat ggtttctaac acgcgccgtc taccactatc
    24421 aatgccaaat agccggacat attcgccgct atgatctctt agacaacttt ctaaagatgc
    24481 gatcgcttca cccattgatc caggttgaat gggttggcaa ctttgccaac aaccagtccg
    24541 gaaacgtctt tcgtctacgt gttcagtacc aattttaaat ccttgattta aaagataacg
    24601 tacctgttct acgatttctg cacccaagct attgctcgac acttcactac tcctttctag
    24661 ctctaaaaca gtaataccag tatttgtata agatttagca atctcatccc gaatgggtgc
    24721 aatacattta ctatccgcag cacacagata accagttctt aaggactgat ttatcccaac
    24781 cacatgatga gcgaactgct gatcttcaac ttcagcattt ggcaaacggt cagcttgatg
    24841 ctgactagta atgattgacc ccgaaggtac atacttacct ggaggaattt ctacatcttt
    24901 aattaaaacg tgcatcatga tgacgcagcc tgcaccaact ctggcgttaa atacagtgga
    24961 acgaaaacca ataaaggcat catctcctac ataagccggc ccatgaatca atgccatgtg
    25021 ggtaatagaa acattttttc ccacccatac cgagtattta ttttggtcat cgccaattac
    25081 tcggccttga tccaatccat gaattactac accatcttga atattagtat tttcaccaat
    25141 aaaaaaaggt gtaccttcat ccgctctaat cgaggtcccc ggagcgacga ttacatttgc
    25201 gcctatccgg acatctccaa taatgttgga agccggatgt acaaatgcgc tttcatggat
    25261 ttttggctcg gctaaattcc tcgaccacgg ggttgggggt gccgccgtgc tgcggactac
    25321 cattgcgaga ttcctcctga attaagcttt ttgtcattcg ctgttcatca ttggcctcaa
    25381 acttatgact aatgagcaat gactaatgac taatgactaa tgactatcga tactgctctt
    25441 ttttgctgta cataaggcga ttttccaagt gaatggtatc aataatcgcc actactgctg
    25501 catccaaagg acgctgttcg ttaccgagaa tttgacgagc ggcactgcca cgagtgacaa
    25561 gcacccactc atctgctcct gcacctacgg tatctgctgc tacttcgtag cttggcagga
    25621 gatttccttc ttcatcgact aattgcaaca acagtagttt gacacctcga agacttggat
    25681 ctttctgtgt gccgactact gtgccacgaa ctttggcaat ttgcattacg aattacggtc
    25741 ttctaccaaa aggacgaatc gcgtttacat tttcccggaa ttgttctacg tcttcggtat
    25801 agcgaattgg taggacgtat tccaagtttt catggggacg agcaatgata tgggtagata
    25861 acacttctcc accgtgaact cgtttgactg attctactcc agcacccacg gaagcttgca
    25921 cttcggaaac gtcacctcga acgatgactg taactcgacc gctaccgatt ttttcatagc
    25981 ccaccaaagt aacacgagcg gctttcacca tcgcatcagc agcttccact actgctggaa
    26041 agcccagagt ttctaccatt cctactgcga ttgacattag ttctaatcct gaattaaagt
    26101 ttttaaccct tgaaaaaagt ggcgctcccg aaagcagccc cgttttttac tttgtttgtt
    26161 ttatcagctt ttaagttcgg aactgttcta cagcttccgt ataccgaatc ggcaagacgt
    26221 attctaggtt ttcgtgggga cgggcaatga tgtgagttga taatacttca ccaccattaa
    26281 ctctcctggc cgcttcaacg ccggcagaaa ccgaagcttg tacttcagat acatctcccc
    26341 gcacaatcac ggttacccta gcgctaccaa ttttttcata tcctactaac gtaacacggg
    26401 cggctttcac catcgcatca gcagcttcta ctactgctgg aaagccttta gtctcaatca
    26461 ttccaactgc aattggcatc gcagaactcc taaaatttga attcgatcag tactgtgttg
    26521 tgaaatgttt aacgggaagg gctgcatatt gagccataaa aacacttcta atattaagca
    26581 taggaaagct tggtcttcct ggcaatataa attagtataa tagtttatga taaaatagtt
    26641 ttaaaaaact taacaaatat ttatacctcg ttctgctcta tcgaagttga tcaattccta
    26701 gagcagacgc ttatgcttta ttattttttt attacattga caaaatgaca ttcatagcta
    26761 tggcaatcaa ctccgccaag ggtctattga tggctgtata ttatgctatc tctaagtttg
    26821 cccgatttga gaagggaaac aacgattacg taaaagatat ataacttttt taaatatatc
    26881 gcataaattt atttgctgaa agtagaaata gaattttata attacaaatg atgtaatagg
    26941 agtaaatgct tttaaatatg taaagttata tttaactata acctaataag gtaagctaaa
    27001 taaaaaatag acattcaaaa tttaggcaag aaatacttaa aaaaactata gaatttatct
    27061 gggttaacta ttttttttag taaatgattg ttgtcaggat ctttaagaaa aatcaaggct
    27121 gagtcgtcaa ggaaaatctc aatgaatcag tttctatttt caataagttg gtgggtgcca
    27181 ttttatagct taattggcgc acttgtaact ttgccctggg caa
//
