LOCUS       NZ_CP053549            11392 bp    DNA     circular CON 17-AUG-2024
DEFINITION  Paenarthrobacter sp. YJN-D chromosome, complete genome.
ACCESSION   NZ_CP053549
VERSION     NZ_CP053549.1
KEYWORDS    RefSeq.
SOURCE      Paenarthrobacter sp. YJN-D
  ORGANISM  Paenarthrobacter sp. YJN-D
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Micrococcaceae; Paenarthrobacter.
REFERENCE   1  (bases 1 to 4334173)
  AUTHORS   Zhang,M.
  TITLE     Comparative genomic analysis of iprodione-degrading
            Paenarthrobacters reveals the iprodione catabolic molecular
            mechanism in Paenarthrobacter sp. strain YJN-5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4334173)
  AUTHORS   Zhang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAY-2020) College of Life Sciences, Nanjing
            Agricultural University, Weigang NO.1, nanjing, jiangsu 210095,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3 OR MAY-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015040335.1-RS_2024_08_17
            Annotation Date                   :: 08/17/2024 05:55:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,216
            CDSs (total)                      :: 4,145
            Genes (coding)                    :: 4,122
            CDSs (with protein)               :: 4,122
            Genes (RNA)                       :: 71
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 23
            CDSs (without protein)            :: 23
            Pseudo Genes (ambiguous residues) :: 0 of 23
            Pseudo Genes (frameshifted)       :: 6 of 23
            Pseudo Genes (incomplete)         :: 18 of 23
            Pseudo Genes (internal stop)      :: 1 of 23
            Pseudo Genes (multiple problems)  :: 2 of 23
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:51:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 41806
            Orig. end                         :: 53198
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053549.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11392
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11392
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11392
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6392](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6392
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    354..365
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(1667..2890)
                     /locus_tag="HMI60_RS00210"
                     /old_locus_tag="HMI60_00210"
     CDS             complement(1667..2890)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMI60_RS00210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMI60_00210"
                     /product="hypothetical protein"
                     /protein_id="WP_193590315.1"
                     /transl_table=11
                     /translation="MTSEVLVVADQKAGNVQFLNPVTGAVQHRLDSVVLAEHAGFLPLG
                     DGRCAFIDDAGGALVIADAFTDTPPCTIPVAIPGEHLACDPSGRFVAVTTGLGVSWEPW
                     SDLLTVVDLESDGGPTSRRIRTRAGEPGVVVGETPEGPAAVVRHREPGCIESFSVERIL
                     SEGVHCPPLQGLRAEASPDGHGDALDPVTGTMFVATGRGLERFDVRKPQPEALDVIAWD
                     APGRAYFLRFCPRRRVLVAILRDGGGEPRGWAQWANTLWVHHVDTGLTRTTPLGHGLVF
                     RFALTANGIATARVHPDGDELSVHHLGPLEAGPPVLRGTWHLPRMDGAPRPGHEPWDNA
                     ERRAIAASPASELVAVTRGGHGELHVVDTSAAGSPLRTINLGSPLHDGGHLAWVSAVDT
                     VPGDTVGR"
     misc_feature    complement(2848..2864)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.46"
                     /tool="antismash"
     misc_feature    2904..2918
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.55"
                     /tool="antismash"
     misc_feature    2911..2926
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.22"
                     /tool="antismash"
     misc_feature    complement(2911..2929)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: medium, score: 27.61"
                     /tool="antismash"
     misc_feature    complement(2913..2927)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.24"
                     /tool="antismash"
     misc_feature    complement(2914..2929)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.14"
                     /tool="antismash"
     misc_feature    2917..2932
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.3"
                     /tool="antismash"
     misc_feature    2939..2951
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            2995..3096
                     /gene="amiA"
                     /locus_tag="HMI60_RS21135"
     CDS             2995..3096
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: protein motif:HMM:NF040714.1"
                     /locus_tag="HMI60_RS21135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_242703463.1"
                     /transl_table=11
                     /translation="MEKTTVLVEVEETEQLAHLSATHSNALVENPFD"
     gene            3170..3898
                     /locus_tag="HMI60_RS00215"
                     /old_locus_tag="HMI60_00215"
     CDS             3170..3898
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMI60_RS00215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMI60_00215"
                     /product="hypothetical protein"
                     /protein_id="WP_193590316.1"
                     /transl_table=11
                     /translation="MGTAIDSFDVAGRSTIRSGDGAFFHLPPSAGGGQHLATGVSDELL
                     QRRQAGALPLPGRELIGLVAPEPVAAALLPVFREAGVDLAVGDDREPGSVGLLLHLATM
                     PAERNRFDALPGRAAVLRFYGEGDLVFVDPLSLEPADPTGWQVLRRRLAASPAAAELRA
                     WLDTPAAAADFALQGMAMDLLTARLLTIITAWQRNSPSLAAHRRTLWRLDTLTLANSEH
                     PVLPFPEPASLGEGLRAPLR"
     gene            3895..5004
                     /locus_tag="HMI60_RS00220"
                     /old_locus_tag="HMI60_00220"
     CDS             3895..5004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00976.1"
                     /locus_tag="HMI60_RS00220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMI60_00220"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_193590317.1"
                     /transl_table=11
                     /translation="MRPATALEHLDITADDGVRLTADHYRTPMEGEVEGTVLIRTPYGR
                     TQYANQAHAWCRAGYDVVVQDVRGRYGSAGTWNPYDKEGPDGAATAKYLAGNGLLNGPL
                     ILAGASYDAHCAVEAARVLEAAQVPEEIRRPEAAGPKPLAVVAMVPALGLYETAREPDG
                     TPRLQDRIGWWHQHGFGKESGHPLPAAELRRIYRQAEERGMDWTIHNLIDDATYGPGST
                     AGWKRLWDASPADLHALYGQLNTPLLMISGQRDFFVAEAADLVRAWGSAAPRTLVETLW
                     GPWGHRLGHDLGAGAAAALREQGGLMARIKDFLGAANDWDPPGARPEPLGNPRPPVLQW
                     EPGDRPHTWRWAPAAPGTLPHHLNNHGES"
     gene            5001..6392
                     /locus_tag="HMI60_RS00225"
                     /old_locus_tag="HMI60_00225"
     CDS             5001..6392
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006501818.1"
                     /locus_tag="HMI60_RS00225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMI60_00225"
                     /product="YcaO-like family protein"
                     /protein_id="WP_193590318.1"
                     /sec_met_domain="YcaO (E-value: 8.3e-46, bitscore: 155.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTAEALGLLPMHTLVDEQTGIIRRVRPVLTPENAPPAYTSMTA
                     EVSNARWLGDWPADRVSLGTTFGDSRQAWIAAVAEGMERYCGNFIPADLPDHHYFTGTA
                     RELTASGRAAVGLEQLPRFADWQLEGAAFPYRNLDADTPALWTACRRESDGSEVWLPAS
                     LTLLNWRQRRFRDLPRIHHLNYAGIATGQGRADATDRAVLETIERDALELWWHLDGPTR
                     GIRPESVPGLVDDMAGCRLQYWVVEMPSEFAPCMAALVFDPDTGLYAAGFSCKNDPAEA
                     ARKAVLEAVHTWIYSQGATDADGWVFQAVEAGLMAKGLYLEHREDRQYLDDVGPGFGAV
                     RDLGAHVQVWLDPRTHVLAERFTQPAGGLVDVAAVDDVSMPELYRRLEAAGHTVYTREL
                     TTPDVAVTGLSVVRAVVGGLVPNAPAAFAYLGCPRFTTAALKRGWRETAPALPEDFTLT
                     PPPHM"
     gene            6392..7540
                     /locus_tag="HMI60_RS00230"
                     /old_locus_tag="HMI60_00230"
     CDS             6392..7540
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMI60_RS00230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMI60_00230"
                     /product="hypothetical protein"
                     /protein_id="WP_193590319.1"
                     /transl_table=11
                     /translation="MDVPHVLLPSGFARAWSHEVPGPQQPPGPQGAPVPGTVEHLRQDG
                     LPVSAMLRAIWWSEDFHPNPATGLPGKVRKRPVPSAGGCYPVQLRVLCGEGCDVPPGTY
                     VFNGSGFSGTGGDLLRLRNHDDGTPPQGGPQAPARGAVVVLTVLPQRTLAKYYHRAGPL
                     LIADAAYAAVALVHHAAAQGVDARWDVVAPVRWPGSVPEFALATVSLGVSAERCLQRRH
                     DRIAGVSQVQLAARRSCEFSRLRARPAAGAGRVAEDLLERSLLSFPEPTPPSCSARILS
                     AEPLRDPELADRCAGQRWIGNLDALVVFETPGTPTPAAMWWAATLAAHILYTALGADLP
                     LEFRPVGGWTGSHSGWTTLHGLGMAIRKPLTANHERAAHAGQ"
     gene            7527..9290
                     /locus_tag="HMI60_RS00235"
                     /old_locus_tag="HMI60_00235"
     CDS             7527..9290
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="HMI60_RS00235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMI60_00235"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_193590320.1"
                     /transl_table=11
                     /translation="MLVNKRLFQMTAGHRGRLAGVTALLCITTASYWLQAWFLAQALAA
                     LVVLVRVPGNPDGGRYGPLVPYLAGVLACGLGRLVLQQFHARLAGSLGSGVRLQVRRKL
                     ADSLLQPERLRDTSDRGGARRLALSEGVDGVDSYISQYIPHAFQLQVVVPTLLVWIAGL
                     NPLLALALATAVAVAVGAPRLWGKTLAKRGQQHWDSYEALGADFLEALQGMRTLKILHA
                     VPRTRARLHQRSQELHRATVSTMRTSLVDTALADFGIQAGMLAAAALATFAALGQGPLP
                     GPESAATTYFLLMLSSEVFRPVRDLARQWHAGYLGLSALGSIDAAGGADTRCGRTPAGE
                     AQVRFAPGSLSALGSLSAPGVRPGVVPPGGLTLHNVSFRYSAADPWVLRDASAEIQPGG
                     LTALAGVSGAGKSTLFDLLLGFLPAGDGHIRLDGQPLRPSDVSVVSQRSYLFPGTIREN
                     FRVVAPAATEEEIQRVVEIAGLAEELWQWPQGLDTVLSEGGGSVSGGQLQRLSIARALL
                     VDRPVLLLDEPTSALNTELAGRVLEGLRREAGRRIVLMIAHRPEALAAADTVLRLAQGQ
                     LQTQQQEAATS"
     gene            9287..10948
                     /locus_tag="HMI60_RS00240"
                     /old_locus_tag="HMI60_00240"
     CDS             9287..10948
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="HMI60_RS00240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMI60_00240"
                     /product="amino acid ABC transporter ATP-binding/permease
                     protein"
                     /protein_id="WP_193590321.1"
                     /transl_table=11
                     /translation="MSLTTRTPRNPLLGLVPHMSGEWAGIVWTAVVGVLNNLALIVLAV
                     VGSYVVALAVMRQESAAAEWWVAGVVAVVLRAVLTWHEMDISHSIAYRILAALRMALFD
                     GFARGVPSRKPDQHTGKLAATAMGDVEKLEFFYAHTVAQLAGSAVLFVAGVAVVWPLGP
                     GLAGALLLGFVALVAVTLPGLRRGAELGVRVQEARSGVSVLAVDLLAGTREILGFGLRE
                     HAQRQLEDQSLAVDAGQRRLNSFLTMAASLRELCVLGTVVAVFLAAISQPGLDPVWLPA
                     LVAGTLTLLAPVAEGVATVTQLQPHRASARRVGEGISLPSAAMVSGPIVDFNPKGPLGL
                     EVRNLQFTYDDGAPALRSTSLSVAPGEHVGISGPSGAGKTTLARLMLRLWVPDAGRIAL
                     VSPSGESVDAWAVDEASFRRMVTLVEQDAPVFHGSVMDNMRLARPAATEADVLSALDLA
                     GLPLTGERWADGVDTVIGEQGVSLSGGERARFCLARALLIKPRILVLDETTASLDPASE
                     RALVEAVAAIAGDTTVITVSHRESTLAACHRRVQLG"
     misc_feature    11162..11175
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.51"
                     /tool="antismash"
     misc_feature    complement(11348..11357)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
ORIGIN
        1 acggcggcgg agaagtccag cacgtccggc gctgcacgct ggccgtgacc gccgcggtcc
       61 tcgtggagta gccaggcccg gtccccgcgt tcgcggattc cggtaacaac atcgacggcg
      121 gcactgttgt ccacgcgttc gtcccgcccc atgaggcagc acagcagggg cggaagcgcg
      181 gcggagccga gtctgcgcag caagtgaacc ggggaatagg ccgcccgatc gtgatcagag
      241 cactccccat cggcgccaaa ctcgtgcagc cattgcttcc ccaaaccatg gcggtgaagg
      301 tccacggtgt ccagcaatgg agctacggcc accactccgc cgaatgaggc gggggacagg
      361 aacgccgcag ccgtgaccac gaggccacca tgcgaggccc cgaaaggcac ggtctgggcg
      421 ggcgtggtcc accgggtatc gacgaggtag ccggccacgt cgatgaggtc caggattgtc
      481 cgcatcttcc gtttcccacg gcctgcctgg tgccaatcct ctcccagctc gcccccgccg
      541 cgtagttgcg cagccacgta caccccgccg ctctccagcc atgccggaac gctgggttcg
      601 gcctcggtcc tgtgtgtgac gccgaaaccg ccgtagcacg tgagaatcag gggcagcggc
      661 tgcaccggga ggccgtcagg accaaggtct gacgcccgtg cggagatgat cacggggatg
      721 ccgatgccgt cgctcgccac cgcggtgact ttccggtgga ctatccggct gctggagtcc
      781 ctggagctgt tgctcaagcg caccggttca tccacgcaga agacccccga tgggcgttcc
      841 ggggaggccg tctggatcca aaggtcggtg gcatcggcgc ggggttggac ggcgaacgct
      901 gacacgtatt ccgcggggga taaacggtag gccgggcggc catccagcgt ggccgtcgtg
      961 ccgtgttggt cggagaccag ttccacacga ccggcttgtg cggccggagc cacggtatgc
     1021 caggccccgg atttcaactc ccactctttg gtgccggtcc ttgggttctt cgccgcgagc
     1081 cgaaggtgct ctccgacgcg tgccagcgcg agacggctgc ccgcggtgtt gccaagttcc
     1141 gccggaagcg ggagctgctg catctgccct gagccgagcg ggcagcggat gatctgctgg
     1201 cagggtggtt tgccggtcag gacccagatc ccgcccccgt ccggctccca aaccggcgca
     1261 gcgtaccagg ccgtcggccc tgggatgtgg acgggctggg tcccggcagc gagtatccag
     1321 ggctccgcta gttcactggc ggaggcgctc agcaaggctg cgacgcgcgt tccgtcaggg
     1381 gagatggtga atccgcggac gatggtgccc ggtggtgtgg ggagtcggac accgggcggc
     1441 gcggccacct ccagatgcgc ccggcgaaca ttccaagcat cccgaagccc ggcctcggct
     1501 gccaggtaca aggacgcaaa cgcttcgtct ggcccgcgcc aaagaaaagc agcctgtccg
     1561 ccggcgaact gtgggagccc ttggcggggt gtggagtccc agcgttccag aagggaacgg
     1621 aagtgcggcc gaagccccat gcccggaacg gcctcctcga tgctgctcac cgtcctaccg
     1681 tgtcgcccgg caccgtgtcc acagcagaga cccaggcgag gtggccgccg tcgtgcaagg
     1741 ggctgcccaa gttgatggtg cgcagagggc taccggccgc tgaggtgtcg acgacgtgca
     1801 gttcgccgtg cccaccgcgg gtcacggcga cgagttccga ggccggcgaa gcggcaatgg
     1861 ctcgtcgttc ggcgttgtcc cagggttcat ggccgggccg tggggcgccg tccatgcggg
     1921 ggaggtgcca tgtgccccgc agcaccggcg ggcctgcctc caatggtcca aggtggtgca
     1981 ccgaaagctc gtcgccgtcc ggatggaccc gggcggtcgc gatgccattg gcagtcagtg
     2041 cgaagcggaa gaccaaccca tggcccagcg gcgtggtccg cgtcagcccg gtatccacgt
     2101 ggtgcaccca caaagtgttg gcccactggg cccatcctct gggctcaccg ccgccgtcgc
     2161 gaaggatagc caccaggaca cggcgccgcg ggcagaagcg caggaagtag gcgcggccgg
     2221 gtgcatccca agcgataacg tcaagggcct ccggctgcgg cttgcggaca tcgaagcgtt
     2281 ccaggccccg gcccgtggcc acgaacatgg tgcccgtgac gggatccaag gcgtcgccgt
     2341 gaccgtcggg cgaggcctcg gcccgcagcc cttgcagggg cgggcagtgc actccctcgg
     2401 acaggatccg ctccacgctg aaggattcga tgcagccggg ttcacggtga cggacgacgg
     2461 cggcgggccc ctccggcgtt tcgcccacca caacgccagg ctcccccgcc ctggtgcgga
     2521 tgcggcgtga ggtgggtccg ccgtcggact ccaagtccac aaccgtgagg agatcgctcc
     2581 aaggttccca cgagacacca agccccgtgg tgacggcaac gaagcgaccc gaagggtcgc
     2641 aggccaggtg ctcacccgga atggctacgg gaatggtgca gggcggggtg tcggtgaatg
     2701 catcggcaat gaccaaggca cctccggcgt catcaatgaa cgcgcatcgt ccgtctccca
     2761 gcggcaggaa cccggcgtgc tccgccaaga ccacggagtc caaacggtgc tggactgccc
     2821 cggtgactgg attcaggaac tgtacattgc ccgctttttg gtcggctaca accaaaactt
     2881 cggaggtcat tggctctccc tttcacttaa tttgagaatg gttctcatta actatagtgt
     2941 gacgttgtcg ccgcaacagc ggaggcaacc accaccaccg aaaggagacc aaccatggaa
     3001 aagaccacgg ttctggttga agttgaagag accgagcagc tggcacacct gtcggcaacg
     3061 cactcgaatg cactggtcga gaacccgttc gactagtcgc taagccaggg ggcgggtgcg
     3121 ccggcgcacc cgccccctta gctccacccc gcaactttcg gaaggaacca tgggcaccgc
     3181 aatagacagc tttgacgtcg cgggaagatc aaccatccgc agcggtgacg gcgccttctt
     3241 ccatctcccg ccctcggcag gaggtggcca acacctggcg acaggcgtca gcgatgaact
     3301 gctgcaacgc cgccaggctg gcgcgcttcc cctccccgga agggagctca tcgggctggt
     3361 agcccccgaa cccgttgctg ccgcactcct gcccgtgttc cgcgaggccg gggtggacct
     3421 ggcggtgggt gacgaccggg agcccggctc cgtaggactc ctcctccacc tggcaaccat
     3481 gcccgccgag cggaaccgct ttgacgcact gccgggccgt gcggccgtgc tccgcttcta
     3541 cggagaaggc gacctggtct tcgtagatcc gctgtctctt gaaccggcag acccaacagg
     3601 gtggcaggta ctccggcgca ggctcgcggc ctcaccggcc gccgccgaac tgcgggcctg
     3661 gctggatacc cccgctgctg ccgcggactt cgctctccag ggcatggcca tggacctgct
     3721 tacggccagg ctgctcacca tcatcaccgc ctggcaaagg aattcaccgt cacttgccgc
     3781 tcaccggcgc acgctctggc ggctggacac cctgacgttg gcaaacagtg aacaccccgt
     3841 tctgcccttc ccggaacccg cgagcctggg cgaaggcttg cgggctccgc tgcgatgaga
     3901 cccgccaccg cgctggagca cctggacatc accgctgacg acggcgttcg gcttaccgca
     3961 gaccactacc gcacaccaat ggagggggaa gtcgaaggga cggtcctgat ccggacaccc
     4021 tatggacgga cccagtacgc gaatcaagcc cacgcatggt gtcgcgccgg gtacgacgta
     4081 gtggtccagg acgtccgtgg gcgctacggg tccgccggca catggaatcc ctatgacaag
     4141 gagggccctg acggggctgc aaccgccaag tacctcgccg gcaacggatt gctcaacggg
     4201 cccctcattt tggctggagc ctcctacgac gcgcactgtg cagttgaagc ggcccgggtc
     4261 ttggaggcgg cgcaggttcc ggaggaaata cggcgtccgg aggcagcggg acccaagcca
     4321 ttggccgtgg tggcgatggt gccggcgctt ggcctctatg aaacggccag ggaacccgat
     4381 ggcacaccgc gccttcagga caggattggc tggtggcacc agcacggttt cggcaaggag
     4441 tccggccacc cgttacccgc cgcagagctc cggaggatat accggcaggc tgaggaacgc
     4501 gggatggact ggacgattca caacctcatc gacgacgcca cgtatggtcc ggggtccacc
     4561 gctggttgga agcggctctg ggacgcctca ccagccgatc tccacgccct ttatggccag
     4621 ctgaacacgc cgctcctgat gatttcggga caacgggact tctttgttgc cgaagctgcg
     4681 gacctggtga gggcctgggg cagcgcagca ccgcggacct tggtggaaac cctttgggga
     4741 ccatggggac accgactcgg ccacgacctc ggcgccggag ccgccgcagc actccgcgaa
     4801 cagggcggcc tgatggcccg gatcaaggac tttctgggtg ctgccaacga ctgggatcca
     4861 cccggcgccc ggcccgagcc ccttggaaac ccgcggccgc cagtcctgca gtgggaaccc
     4921 ggcgaccgac cacacacatg gcgctgggcg cccgccgccc ccgggacgct gccgcaccac
     4981 ctgaacaacc acggagaatc atgaccacaa cagccgaagc cctgggcctg cttcccatgc
     5041 acaccttggt ggacgaacag accggcatca tccgcagggt ccgtcctgtt ctcaccccgg
     5101 agaacgcccc acccgcctac acgtccatga ccgcggaggt atcgaacgcg cgctggctgg
     5161 gtgactggcc cgccgaccgc gtctcactgg gcaccacctt cggcgacagc cggcaagcct
     5221 ggatcgcggc cgtcgccgaa ggcatggaaa ggtactgcgg caacttcatc cccgcagatc
     5281 tcccggacca ccactacttc accgggacgg cccgtgagct gacggcgtca ggccgggccg
     5341 ccgtcgggct tgaacaactg ccgcgattcg cggactggca gctggagggg gcggcatttc
     5401 cctaccggaa cctcgacgcc gacactccag cactatggac ggcgtgcagg cgggaatcgg
     5461 acggctctga ggtgtggctt ccggcgagcc tcaccctcct gaactggcgg caacggcgct
     5521 tccgtgacct tccccggatc catcatctga actacgcggg gatcgccacc ggccagggcc
     5581 gcgctgatgc cacggacagg gcggtgctgg aaaccatcga acgcgacgcc ctggaactgt
     5641 ggtggcattt ggacggtccc acccgcggca tcaggccaga gagtgttccc ggtttggtgg
     5701 acgacatggc cggttgccgg ttgcagtact gggtggtgga aatgcccagt gagttcgccc
     5761 cctgcatggc tgccttggtg ttcgacccgg acactgggct gtacgctgcc gggttctcct
     5821 gcaagaacga tcccgctgaa gcggcacgca aggcagtcct ggaggctgtc cacacctgga
     5881 tctactccca gggtgccact gatgccgatg gttgggtttt ccaggcagtc gaggcagggc
     5941 tcatggccaa ggggctgtac ctggaacacc gcgaagaccg tcaatacctg gacgacgtgg
     6001 ggcccggatt cggtgcagtc cgcgacctcg gtgcgcatgt acaggtatgg cttgatcccc
     6061 ggacacacgt cctcgcggaa cgcttcaccc agcctgcggg tgggctggtg gacgttgccg
     6121 ccgtggatga cgtgtccatg ccggagctct acaggcggtt ggaagcggcc ggccataccg
     6181 tatatacccg cgaactgacc acccccgacg tcgcggtgac cggcctgagt gttgtccgcg
     6241 ctgtggtggg aggactggtt cccaacgccc cggccgcttt cgcctatctc ggctgcccca
     6301 ggttcaccac ggcggccttg aagcgcgggt ggcgtgaaac ggcgccggca ctgccggagg
     6361 acttcaccct caccccacct ccccacatgt aatggacgta ccccacgtgc tccttccctc
     6421 tggatttgcc cgcgcctgga gccacgaggt tcccggtccc cagcagccgc ccggtcccca
     6481 aggcgccccg gtacccggca cggttgagca cctgaggcag gatgggctgc cagtgtccgc
     6541 catgctccgg gccatctggt ggagcgagga cttccacccc aatcccgcca cgggactgcc
     6601 cggcaaagtg cgcaaacgcc cagtgccgtc ggccggcggg tgctacccgg tgcaactgcg
     6661 ggtcctctgc ggggaaggct gcgacgtgcc tcccggaaca tacgtgttta acggctccgg
     6721 ctttagtggc accggcggtg acctgcttcg cctgcggaac cacgacgacg gtaccccacc
     6781 tcaagggggt ccgcaggcac ccgcgcgggg cgccgtcgtc gtgctcaccg tgctgccgca
     6841 acgcaccctg gcgaagtatt accaccgtgc gggtccgctg ctgatcgcgg acgctgccta
     6901 tgcggcggtg gccctggttc accatgccgc cgcccaaggt gtggacgccc ggtgggatgt
     6961 tgttgcaccg gtccgttggc ctggctctgt cccggagttc gcgctggcca cggtgtctct
     7021 gggggtgtct gcggagaggt gcctgcagcg ccgtcatgac cggatcgccg gggtttcgca
     7081 agtgcagctg gctgcccgca ggagctgtga gttctcccgt ttgcgtgccc gcccggccgc
     7141 cggcgcgggc cgggtggctg aggacctcct ggagcgttcc ctcctttcct tcccggagcc
     7201 aacccctccg tcctgcagcg cccgcatcct gtccgcggag ccgctccgcg atccggagct
     7261 ggccgatcga tgtgccgggc agcgctggat aggaaacctt gatgccctgg tggttttcga
     7321 gaccccggga acgccaaccc cggccgccat gtggtgggcc gccacgttgg ccgcccacat
     7381 cctctatacc gcgttggggg cggacctgcc cctggaattt cggccggtag gtggctggac
     7441 cggctcccac agcggctgga caacgctcca tggactggga atggcaatcc ggaaaccact
     7501 caccgcaaac cacgaaaggg ccgcgcatgc tggtcaataa gaggctcttc caaatgacgg
     7561 ccgggcaccg cggccgactg gctggggtaa cagccctgct ctgcatcacc acggcgagct
     7621 actggttgca ggcgtggttc ctggcccagg ccctggcggc cctggtggtt ctggtgcggg
     7681 ttcccggaaa ccccgacggc ggcaggtacg ggccgctggt tccgtacctt gcaggggttc
     7741 tcgcgtgtgg cctggggcgc cttgtactcc agcagttcca cgcccggctg gccggttcct
     7801 tgggctccgg ggtgcggttg caggtacgcc gaaagttggc cgacagcctg ctccagcccg
     7861 aacggctcag ggatacctcg gaccgtggtg gagcccggcg gctggccctg agcgaaggtg
     7921 tggacggagt ggacagctac atcagccagt acattcccca cgctttccaa ctgcaggtag
     7981 tggtgccaac gcttcttgtc tggatcgcgg ggctgaatcc cttgttggct cttgcgctgg
     8041 ccactgccgt ggccgtggct gttggtgcgc cgaggctctg gggtaagacc ctggcgaaac
     8101 gcggacagca gcactgggac agttacgagg cccttggcgc cgacttcctg gaggcccttc
     8161 aagggatgcg gaccctcaag atcctccacg ccgttccccg gacaagagcg cggctccatc
     8221 agaggtcgca ggagctccac cgggcaaccg tctccaccat gcgcacgtcc ctggtggaca
     8281 cagcgttggc ggacttcggg atccaggcag ggatgctggc cgccgccgcg ctagccacat
     8341 tcgcagcgct ggggcagggg ccactgcccg gaccggagag tgcggcgacc acgtatttcc
     8401 tgctgatgct ctcgtcggaa gtcttcaggc ctgtgcggga tctggcacgc caatggcatg
     8461 ccgggtatct ggggctctcg gctctgggga gcattgacgc agcgggaggc gcggacaccc
     8521 gctgtggccg tacgccggcg ggcgaagccc aggtgcgttt cgcgcctggt tccctttccg
     8581 cgcttggttc cctttccgcg cctggggtgc gtcccggcgt cgtgcctccc ggtggtctca
     8641 cgctgcacaa cgtgagcttc cgatactcag ctgcggaccc ctgggttctg cgggatgcgt
     8701 cggcggagat ccagcccggc ggcctcaccg cgctggcggg ggtgtcaggg gcggggaaga
     8761 gcacgttgtt cgaccttctg ctggggttcc tcccagcggg ggacggacat attcgtctgg
     8821 acggtcaacc actcaggccc agtgacgtca gcgtggtctc acaacgcagc tacctctttc
     8881 ccgggaccat ccgggagaac ttccgggtgg tggcgcctgc tgccacggag gaggaaatcc
     8941 agcgcgtcgt ggagattgcc ggcctggcgg aagaactatg gcagtggccc caaggcctgg
     9001 acactgtgct gtccgaaggg ggcggatccg tctcgggagg ccagctccag cggctttcga
     9061 ttgcacgggc actcctggtg gacaggccgg ttctcctgct ggacgagcca acgtccgccc
     9121 tcaacaccga gctcgctggg cgggtgttgg aggggcttcg ccgcgaagcc ggacgccgga
     9181 ttgtgctcat gatcgcccac cggcccgaag ccctcgctgc cgctgacacc gtactccgcc
     9241 tggcacaagg ccaactccaa acacagcaac aggaagcagc cacgtcatga gcctcaccac
     9301 acgcacaccc cgcaacccgc tcctgggcct ggttccgcac atgtccggcg agtgggcagg
     9361 gatagtctgg accgccgttg tgggcgtcct gaacaatctg gcgctgattg tcctggcggt
     9421 tgtgggttcc tacgttgtgg cgctggctgt gatgaggcag gagtccgcag ccgccgaatg
     9481 gtgggttgcc ggggtggtgg ccgtggtgct cagggcggtg ctgacgtggc atgagatgga
     9541 tatctcgcac agcattgcgt accggatcct ggccgcgctg cgcatggcac tctttgacgg
     9601 tttcgcgcgc ggtgtccctt cccgcaagcc ggaccagcac actggaaaac tcgccgccac
     9661 ggccatgggc gatgttgaaa agctggagtt cttctacgcc cacacggttg cccagctggc
     9721 tggctccgca gtgctgttcg tggccggggt agctgtggtg tggccgctgg ggccgggcct
     9781 ggccggggcc ttgctgctgg ggttcgtggc gctggtagcg gtgacactgc cgggattgcg
     9841 ccggggcgcc gagctgggtg tgagggtgca ggaggccagg tccggggtgt cggtactcgc
     9901 cgtggacctg ctggccggca cccgcgagat cctgggattc ggactgcggg agcacgcgca
     9961 acgccaactg gaggaccaga gcctggcagt ggatgccggc cagcgcaggc tcaactcttt
    10021 ccttacgatg gcagcgtcct tgcgcgagtt gtgtgtcctg ggcaccgtgg tggcggtctt
    10081 ccttgctgcc atctcacaac ccgggctgga tcctgtgtgg ctgcccgcct tggtggccgg
    10141 cactttgacc ctcctggctc cggtggccga gggcgttgcc accgtaaccc agctccagcc
    10201 gcaccgtgcc agtgcccggc gcgttgggga gggcatcagc ctgccctcgg ccgcaatggt
    10261 ttcgggcccc atcgttgact tcaaccccaa ggggccgctg ggtctggagg tccggaacct
    10321 gcagttcacc tacgacgacg gcgcgccggc tttgcgctcg acgtccctgt cggtggcgcc
    10381 cggcgagcat gtggggatca gtggcccctc cggtgcagga aagaccacac tggcccggct
    10441 gatgttgcgc ctgtgggtgc cggatgcggg gaggatcgcc ttggtgtcgc ccagcgggga
    10501 gtccgtggac gcttgggcgg tggacgaggc gtcgttccgg cgcatggtca ccttggtgga
    10561 gcaggacgcc ccggttttcc acggttctgt catggacaac atgcgcttgg cccgccccgc
    10621 ggcaactgaa gccgacgtcc tgtcagcctt ggacctggcc gggcttccgc tcaccggcga
    10681 acgatgggcg gatggcgtgg ataccgtgat cggcgagcaa ggggtgagcc tgtccggggg
    10741 tgagcgtgcc cgcttctgct tggcgagggc cctgctgatc aagcccagga tcctggtgct
    10801 ggatgaaacc acagccagcc tggatcctgc ctcggagcgt gccctggtgg aggctgttgc
    10861 tgcgatcgcc ggcgacacca cggtgatcac ggtgtcccac agggagtcaa ccctggccgc
    10921 atgtcaccga cgggtgcagc tgggctagcg tccctcttcc cccgcccgtc ctctcgggcg
    10981 ggggttttgg agggtttaga acgcgtcggg gtggaggccc ttggcgatct gctctacggc
    11041 gcggaggttg ccccaggttc cgggcatgac gtcagcggaa tcgatggcca ccaatcgctg
    11101 gttcttcacg gcgtctacct cagggaattt ctcctgaagg aaggtgcggg tggcgtcctc
    11161 gtgggccttg tccaaggtgg tgaatacgat gacctcgggg ttcttctgca ccagcgtctc
    11221 aggggagatc atggcagaga agaacttggc gaaggcttca tcggacgggc tgaagaggtt
    11281 ctcgccaccg gcagtcttga tcatgtcgta ctcgatccct gccccgatgg ccgcaatgga
    11341 gttcccttca acaaacagct ccaccacggt gggcttctcc ttgccttcca cc
//
