GCF_014836905.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JACSPZ010000014.1 (Solibacillus faecavium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	lanthipeptide-class-ii	12,267	35,305

NZ_JACSPZ010000002.1 (Solibacillus faecavium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 18.1	betalactone	511,812	536,068	Low	fengycin	NRPS:Type I
Region 18.2	terpene	655,219	676,040

NZ_JACSPZ010000003.1 (Solibacillus faecavium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	NRP-metallophore,NRPS	275,568	329,005	Medium	bacillibactin	NRPS:Type I

NZ_JACSPZ010000004.1 (Solibacillus faecavium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 20.1	terpene-precursor	61,369	82,253

NZ_JACSPZ010000005.1 (Solibacillus faecavium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	NRPS-like	53,030	95,987

NZ_JACSPZ010000008.1 (Solibacillus faecavium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	T3PKS	51,202	92,284

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	lanthipeptide-class-ii	12,267	35,305
Region 18.1	betalactone	511,812	536,068	Low	fengycin	NRPS:Type I
Region 18.2	terpene	655,219	676,040
Region 19.1	NRP-metallophore,NRPS	275,568	329,005	Medium	bacillibactin	NRPS:Type I
Region 20.1	terpene-precursor	61,369	82,253
Region 21.1	NRPS-like	53,030	95,987
Region 24.1	T3PKS	51,202	92,284

No secondary metabolite regions were found in these records:: NZ_JACSPZ010000010.1 (Solibacillus faecavium); NZ_JACSPZ010000011.1 (Solibacillus faecavium); NZ_JACSPZ010000012.1 (Solibacillus faecavium); NZ_JACSPZ010000013.1 (Solibacillus faecavium); NZ_JACSPZ010000015.1 (Solibacillus faecavium); NZ_JACSPZ010000016.1 (Solibacillus faecavium); NZ_JACSPZ010000017.1 (Solibacillus faecavium); NZ_JACSPZ010000018.1 (Solibacillus faecavium); NZ_JACSPZ010000019.1 (Solibacillus faecavium); NZ_JACSPZ010000001.1 (Solibacillus faecavium); NZ_JACSPZ010000020.1 (Solibacillus faecavium); NZ_JACSPZ010000021.1 (Solibacillus faecavium); NZ_JACSPZ010000022.1 (Solibacillus faecavium); NZ_JACSPZ010000023.1 (Solibacillus faecavium); NZ_JACSPZ010000024.1 (Solibacillus faecavium); NZ_JACSPZ010000025.1 (Solibacillus faecavium); NZ_JACSPZ010000006.1 (Solibacillus faecavium); NZ_JACSPZ010000007.1 (Solibacillus faecavium); NZ_JACSPZ010000009.1 (Solibacillus faecavium)

Compact view

NZ_JACSPZ010000014.1 - Region 1 - lanthipeptide-class-ii

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Location: 12,267 - 35,305 nt. (total: 23,039 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

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Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

H9635_RS18405: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.58	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.54	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.53	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000500.5	0.48	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.48	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0001407.5	0.47	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.58	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.54	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.53	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000500.5	0.48	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.48	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0001407.5	0.47	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for H9635_RS18405

H9635_RS18390

Leader:

MEKVVGMSMKKLEKGEMEKIYGA

Core:

SGVVEPHTTPILSAATKSSKKCLGAISAISGLVSYNKDCLG

Core with dehydrations:

DhaGVVEPHDhbDhbPILDhaAADhbKDhaDhaKKCysLGAIDhaAIDhaGLVDhaYNKDCysLG

antiSMASH-DB 4.0 matches for H9635_RS18390

100.0%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

1

SGVVEPHTTPILSAATKSSKKCLGAISAISGLVSYNKDCLG

41

SGVVEPHTTPILSAATKSSKKCLGAISAISGLVSYNKDCLG

1

SGVVEPHTTPILSAATKSSKKCLGAISAISGLVSYNKDCLG

41

62.8%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

4

VEPHTTP--ILSAATKSSKKCLGAI-SAISGLVSYNKDCLG

41

VEP TP I+SA T+SSK C+ AI SAISG++S+NKDCLG

3

VEPRGTPATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

56.1%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27550_lanthipeptide

4

VEPHTTPILSAATK-SSKKCLGAISAISGLVSYNKDCLG

41

V+ T P + ++ SS KC ISAISGLVSYNKDCLG

3

VDTRTHPTVIVVSRISSAKCASTISAISGLVSYNKDCLG

41

with 38 more sequence matches

Only the first 10 are displayed here.

53.3%

NC_003028.3and 39 others:

NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptideNZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide

Lanthipeptides: SP_RS09790_lanthipeptide

5

EPHTTP---ILSAATKSSKKCL-GAISAISGLVSYNKDCLG

41

EP TP IL +A SSK C+ A+S I GLVSYN DCLG

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

53.3%

NZ_CP035244.1and 3 others:

NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide

Lanthipeptides: EQH36_RS09100_lanthipeptide

5

EPHTTP---ILSAATKSSKKCL-GAISAISGLVSYNKDCLG

41

EP TP IL +A SSK C+ A+S I GLVSYN DCLG

5

EPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNNDCLG

45

53.3%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16390_lanthipeptide

Lanthipeptides: KNQ12_RS14665_lanthipeptide

4

VEPHTTPILS----AATKSSKKCLGA-ISAISGLVSYNKDCLG

41

V+P TP++S + KS+K C+GA SAISG+VS+NKDCLG

3

VDPRWTPVISLVARSIVKSTKACIGAGASAISGIVSHNKDCLG

45

53.3%

NZ_JALDUX010000010.1:

Lanthipeptides: M1F92_RS09530_lanthipeptide

5

EPHTTP---ILSAATKSSKKCLGA-ISAISGLVSYNKDCLG

41

EP TP IL +A SSK C+ A +S I GLVSYN DCLG

5

EPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

45

53.3%

NZ_JAMYJM010000002.1:

Lanthipeptides: NKE69_RS04880_lanthipeptide

5

EPHTTP---ILSAATKSSKKCLGAI-SAISGLVSYNKDCLG

41

EP TP IL +AT SSK C+ A+ S I G+VSYN DCLG

5

EPRWTPTPFILKSATASSKVCISAVVSGIGGIVSYNNDCLG

45

51.1%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25230_lanthipeptide

4

VEPHTTPILSAATKSS----KKCLGAI-SAISGLVSYNKDCLG

41

V+P TPI SAA S+ K C+ A+ SAI G+VSYNK+C G

3

VDPRWTPIASAAINSAARSSKICISAVGSAIGGIVSYNKNCAG

45

51.1%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06300_lanthipeptide

5

EPHTTP---ILSAATKSSKKCLGAI-SAISGLVSYNKDCLG

41

EP TP IL +A +SSK C+ AI S I G+ SYN DCLG

5

EPLWTPTPTILKSAARSSKVCISAIISGIGGIFSYNNDCLG

45

48.9%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

5

EPHTTP----ILSAATKSSKKCLGAI-SAISGLVSYNKDCLG

41

+P TP +LSA +S++ C+ I SAISG+VS+NKDCLG

4

DPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCLG

45

48.8%

NZ_KB976303.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide

Lanthipeptides: IGY_RS26045_lanthipeptide

4

VEPHTTP-ILSAATKSSKKCLGAISAISGLVSYNKDCLG

41

V+ T P ++ + SSK C+ +SAISGL+SYNKDC+G

3

VDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG

41

47.8%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14400_lanthipeptide

4

VEPHTTP-----ILSAATKSSKKCLGAI-SAISGLVSYNKDCLG

41

VEP TP I +A SSK CL + SAI G+ S+N DCLG

3

VEPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNNDCLG

46

MIBiG 4.0 matches for H9635_RS18390

12.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

12

LSAATKSSKKC

22

+SAA + KC

23

VSAAFCPTTKC

33

H9635_RS18395

Leader:

MNVNSTVGKSLKKLNKTEMEKVFGA

Core:

TGSEIQPQSTPLCSFLASYIISAQFKCGGDNKP

Core with dehydrations:

DhbGDhaEIQPQDhaDhbPLCysDhaFLADhaYIIDhaAQFKCysGGDNKP

antiSMASH-DB 4.0 matches for H9635_RS18395

100.0%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18395_lanthipeptide

1

TGSEIQPQSTPLCSFLASYIISAQFKCGGDNKP

33

TGSEIQPQSTPLCSFLASYIISAQFKCGGDNKP

1

TGSEIQPQSTPLCSFLASYIISAQFKCGGDNKP

33

57.1%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

3

SEIQPQSTP---LCSFLASYIISAQFKCGGDNK

32

S + P++TP L SF+ASYI SAQF+CG DNK

1

SGVDPRTTPSPLLASFVASYIASAQFRCGKDNK

33

57.1%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

3

SEIQPQSTP---LCSFLASYIISAQFKCGGDNK

32

S + P++TP L SF+ASYI SA+FKCG DNK

1

SGVDPRTTPSPLLASFVASYIASAEFKCGKDNK

33

with 76 more sequence matches

Only the first 10 are displayed here.

55.9%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27545_lanthipeptide

3

SEIQPQSTP----LCSFLASYIISAQFKCGGDNK

32

S + P++TP L SF+ASYI SA+F+CG DNK

1

SGVTPRTTPATTLLASFVASYIASAEFRCGKDNK

34

54.3%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

3

SEIQPQSTP---LCSFLASYIISAQFKCGGDNK

32

S + P++TP L SF+ASYI SA+F+CG DNK

1

SGVDPRTTPSPLLASFVASYIASAEFRCGKDNK

33

54.3%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

3

SEIQPQSTP---LCSFLASYIISAQFKCGGDNK

32

S + P++TP L SF+ASYI SAQ++CG DNK

1

SGVDPRTTPSPLLASFVASYIASAQYRCGKDNK

33

54.1%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08665_lanthipeptide

1

TGSEIQPQSTPLC----SFLASYIISAQFKCGGDNK

32

TG + + +ST LC SF+ASY+ SA FKCG DNK

1

TGMDAEVRSTLLCGMGISFVASYLASAAFKCGKDNK

36

45.9%

NC_003028.3and 45 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

6

QPQSTPLCS----FLASYIISAQFKCGGDNK

32

P+ST +CS F+ASY+ SAQ +CG DNK

5

DPRSTIICSATLSFIASYLGSAQTRCGKDNK

35

45.9%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

6

QPQSTPLCS----FLASYIISAQFKCGGDNK

32

P+ST +CS F+ASY+ SAQ +CG DNK

5

DPRSTTICSATLSFIASYLGSAQTRCGKDNK

35

44.7%

NZ_CP084237.1:

Lanthipeptides: RES5_RS11640_lanthipeptide

3

SEIQPQSTP---LCSFLAS----YIISAQFKCGGDNK

32

SE++ + TP + SF+A+ Y SA FKCG DNK

1

SEVELRGTPTIGIASFVATIPTGYTASAAFKCGKDNK

37

43.2%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00310_lanthipeptide

2

GSEIQPQSTPLCS----FLASYIISAQFKCGGDNK

32

G++ +STP+CS F+A+Y+ SA CG DNK

2

GADADVRSTPICSAGISFIATYLGSAATNCGKDNK

36

43.2%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23820_lanthipeptide

2

GSEIQPQSTPLC----SFLASYIISAQFKCGGDNKP

33

G +++ +ST +C SF+ SY+ SA FKCG NK

2

GMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

43.2%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06305_lanthipeptide

6

QPQSTPLCS----FLASYIISAQFKCGGDNK

32

P+S+ +CS F+ASY+ SAQ +CG DNK

5

DPRSSIICSATLSFIASYLGSAQTRCGKDNK

35

MIBiG 4.0 matches for H9635_RS18395

15.2%

BGC0000580.3 (EGD17354.1):

Lasso peptide: xanthomonin II or xanthomonin I

23

AQFKCGGDNKP

33

A + GG N P

5

AGEEIGGFNVP

15

allorf_13949_14095

Leader:

MQNKGHPVIAG

Core:

RSSRKPLDELTSTVTRRRQPFRRITITSCPKHKKLSK

Core with dehydrations:

RDhaDhaRKPLDELDhbDhaDhbVDhbRRRQPFRRIDhbIDhbDhaCysPKHKKLDhaK

antiSMASH-DB 4.0 matches for allorf_13949_14095

100.0%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_13949_14095_lanthipeptide

1

RSSRKPLDELTSTVTRRRQPFRRITITSCPKHKKLSK

37

RSSRKPLDELTSTVTRRRQPFRRITITSCPKHKKLSK

1

RSSRKPLDELTSTVTRRRQPFRRITITSCPKHKKLSK

37

18.9%

NZ_JACHXK010000003.1:

Lanthipeptides: allorf_151043_151273_lanthipeptide

8

DELTSTVTRRRQPFRR

23

D +T RR+PFR+

4

DAMTINWFLRRKPFRQ

19

18.9%

NZ_MSRJ01000005.1:

Lanthipeptides: allorf_220341_220451_lanthipeptide

12

STVTRRRQPFRRI

24

ST+T R P+ RI

1

STLTHVRNPWERI

13

allorf_13953_14108

Leader:

MDNFLCLGHDVIVMRRNGCLRRVTVLVS

Core:

SSSGFLDDLPAITGCPLFCTVYS

Core with dehydrations:

DhaDhaDhaGFLDDLPAIDhbGCysPLFCysDhbVYDha

antiSMASH-DB 4.0 matches for allorf_13953_14108

100.0%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_13953_14108_lanthipeptide

1

SSSGFLDDLPAITGCPLFCTVYS

23

SSSGFLDDLPAITGCPLFCTVYS

1

SSSGFLDDLPAITGCPLFCTVYS

23

51.6%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_27695_27844_lanthipeptide

1

SSSGFLDDLPAITGCPLF

18

SSS FLDDLPAITGCP F

1

SSSDFLDDLPAITGCPFF

18

15.6%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_202437_202625_lanthipeptide

2

SSGFLDDLPAITGCP

16

+S L P +TGCP

21

ASHRLAQAPPLTGCP

35

with 2 more sequence matches

13.0%

NZ_CP011130.1and 5 others:

NZ_CP023465.1 Lanthipeptides: CNO08_RS25510_lanthipeptideNZ_CP076103.1 Lanthipeptides: KME82_RS02870_lanthipeptideNZ_CP094357.1 Lanthipeptides: IEQ11_RS02795_lanthipeptideNZ_KQ061218.1 Lanthipeptides: WN54_RS23295_lanthipeptideNZ_LMHM01000017.1 Lanthipeptides: ASD86_RS21560_lanthipeptide

Lanthipeptides: LC55x_RS02840_lanthipeptide

10

PAITGCPL

17

PAITGC L

36

PAITGCSL

43

12.7%

NZ_NNBO01000009.1:

Lanthipeptides: allorf_135626_135823_lanthipeptide

7

DDLPAITGCPLF

18

D+LPA T PL

34

DELPAETHVPLL

45

allorf_14142_14261

Leader:

MEALLGEEGG

Core:

PIQHESLRLFVLNCQLVFVVCSSISNSPP

Core with dehydrations:

PIQHEDhaLRLFVLNCysQLVFVVCysDhaDhaIDhaNDhaPP

antiSMASH-DB 4.0 matches for allorf_14142_14261

100.0%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_14142_14261_lanthipeptide

1

PIQHESLRLFVLNCQLVFVVCSSISNSPP

29

PIQHESLRLFVLNCQLVFVVCSSISNSPP

1

PIQHESLRLFVLNCQLVFVVCSSISNSPP

29

27.6%

NZ_LN827929.1:

Lanthipeptides: allorf_0804035_0804268_lanthipeptide

3

QHESLRLF--VLNC

14

QH S+R+F V NC

4

QHGSIRVFTTVQNC

17

21.8%

NZ_EQ973330.1:

Lanthipeptides: allorf_437242_437442_lanthipeptide

5

ESLRLFVLNCQLVFVVCSSISNSPP

29

SL + L QL C SIS SPP

26

ASLVGWGLLVQLCRGACFSISPSPP

50

MIBiG 4.0 matches for allorf_14142_14261

13.8%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

10

FVLNCQLVFVVC

21

FV+ + +VC

11

FVIQGSTICLVC

22

allorf_27695_27844

Leader:

MIVMRRNGCLRRVTVLVS

Core:

SSSDFLDDLPAITGCPFFLHSIFQHQQGGLF

Core with dehydrations:

DhaDhaDhaDFLDDLPAIDhbGCysPFFLHDhaIFQHQQGGLF

antiSMASH-DB 4.0 matches for allorf_27695_27844

100.0%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_27695_27844_lanthipeptide

1

SSSDFLDDLPAITGCPFFLHSIFQHQQGGLF

31

SSSDFLDDLPAITGCPFFLHSIFQHQQGGLF

1

SSSDFLDDLPAITGCPFFLHSIFQHQQGGLF

31

51.6%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_13953_14108_lanthipeptide

1

SSSDFLDDLPAITGCPFF

18

SSS FLDDLPAITGCP F

1

SSSGFLDDLPAITGCPLF

18

19.4%

NZ_KQ759763.1:

Lanthipeptides: allorf_2608633_2608755_lanthipeptide

15

CPFFLHSIFQ

24

CP HSIF

19

CPVTWHSIFS

28

with 4 more sequence matches

18.5%

NZ_CP076103.1:

Lanthipeptides: KME82_RS02870_lanthipeptide

3

SDFLDDL-PAITGCPFFLHSI

22

SD + ++ PAITGC SI

28

SDIIGEVAPAITGCSLCTGSI

48

16.7%

NZ_CP011130.1and 4 others:

NZ_CP023465.1 Lanthipeptides: CNO08_RS25510_lanthipeptideNZ_CP094357.1 Lanthipeptides: IEQ11_RS02795_lanthipeptideNZ_KQ061218.1 Lanthipeptides: WN54_RS23295_lanthipeptideNZ_LMHM01000017.1 Lanthipeptides: ASD86_RS21560_lanthipeptide

Lanthipeptides: LC55x_RS02840_lanthipeptide

3

SDFLDDL-PAITGCPFFLHSI

22

SD + ++ PAITGC S+

28

SDIIGEVAPAITGCSLCTGSM

48

15.6%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_202437_202625_lanthipeptide

2

SSDFLDDLPAITGCPFF

18

+S L P +TGCP

21

ASHRLAQAPPLTGCPPL

37

10.1%

NZ_LMEQ01000012.1:

Lanthipeptides: ASD48_RS22460_lanthipeptide

3

SDFLDDLPA

11

SD+LDD PA

38

SDYLDDPPA

46

allorf_31515_31709

Leader:

MKPSSCFLTSSKMLASKAAGG

Core:

FSFDSYRHPYVQLPPGVINDHKSPLYCLSSPSIKSIALRLIRY

Core with dehydrations:

FDhaFDDhaYRHPYVQLPPGVINDHKDhaPLYCysLDhaDhaPDhaIKDhaIALRLIRY

antiSMASH-DB 4.0 matches for allorf_31515_31709

100.0%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_31515_31709_lanthipeptide

1

FSFDSYRHPYVQLPPGVINDHKSPLYCLSSPSIKSIALRLIRY

43

FSFDSYRHPYVQLPPGVINDHKSPLYCLSSPSIKSIALRLIRY

1

FSFDSYRHPYVQLPPGVINDHKSPLYCLSSPSIKSIALRLIRY

43

16.7%

NZ_LIXJ01000004.1and 2 others:

NZ_LIXJ01000004.1 Lanthipeptides: allorf_214892_215122_lanthipeptideNZ_LIXJ01000004.1 Lanthipeptides: allorf_214892_215122_lanthipeptide

Lanthipeptides: allorf_214892_215122_lanthipeptide

7

RHPYVQLPPGVINDHKSPLYCLSSPSIKSI

36

RHP+ ++PPG + +P+ S P + S+

28

RHPHPRVPPGQKDGGAAPMS--SGPRVGSM

55

16.3%

NZ_CP045803.1:

Lanthipeptides: V519_RS20085_lanthipeptide

30

SPSIKSIALRLI

41

+PSI SIA R +

4

TPSISSIATRTV

15

with 2 more sequence matches

14.0%

NZ_BMNG01000007.1:

Lanthipeptides: allorf_287629_287730_lanthipeptide

22

KSPLYCLSSPSIKSIALR

39

++PL+C + +S+A R

2

RAPLHCGRNRRPRSVAFR

19

14.0%

NZ_CP017077.1:

Lassopeptides: BES08_RS33485_lassopeptide

14

PPGVINDH

21

PPGVI+D+

2

PPGVIDDN

9

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.75 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.56 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.74 out of 25.88

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.68 out of 24.78

Confidence: medium

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 19.91 out of 29.72

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

H9635_RS18390 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3922.1 Da

Molecular weight: 3924.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3942.5 Da N = 1; 3960.5 Da N = 2; 3978.6 Da N = 3; 3996.6 Da N = 4; 4014.6 Da N = 5; 4032.6 Da N = 6; 4050.6 Da N = 7; 4068.7 Da N = 8

H9635_RS18395 - Class II

Cleavage pHMM score: 2.90

RODEO score: 0

Monoisotopic mass: 3360.7 Da

Molecular weight: 3362.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3380.8 Da N = 1; 3398.8 Da N = 2; 3416.8 Da N = 3; 3434.8 Da N = 4; 3452.9 Da N = 5

allorf_13949_14095 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 4226.5 Da

Molecular weight: 4228.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4247.0 Da N = 1; 4265.0 Da N = 2; 4283.0 Da N = 3; 4301.0 Da N = 4; 4319.0 Da N = 5; 4337.1 Da N = 6; 4355.1 Da N = 7; 4373.1 Da N = 8; 4391.1 Da N = 9

allorf_13953_14108 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 2284.1 Da

Molecular weight: 2285.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2303.6 Da N = 1; 2321.6 Da N = 2; 2339.6 Da N = 3; 2357.6 Da N = 4

allorf_14142_14261 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 3135.7 Da

Molecular weight: 3137.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3155.7 Da N = 1; 3173.7 Da N = 2; 3191.7 Da N = 3

allorf_27695_27844 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 3333.6 Da

Molecular weight: 3335.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3353.7 Da N = 1; 3371.7 Da N = 2; 3389.7 Da N = 3; 3407.8 Da N = 4

allorf_31515_31709 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 4850.6 Da

Molecular weight: 4853.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4871.6 Da N = 1; 4889.6 Da N = 2; 4907.6 Da N = 3; 4925.7 Da N = 4; 4943.7 Da N = 5; 4961.7 Da N = 6

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_JACSPZ010000002.1 - Region 1 - betalactone

Download region GenBank file

Download region SVG

Location: 511,812 - 536,068 nt. (total: 24,257 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

H9635_RS06055: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

H9635_RS06090: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase methyltransferase transferase

H9635_RS06060: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

H9635_RS06080: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

H9635_RS06125: methyltransferase

smcogs: SMCOG1248: methyltransferase

Lyases: hydratase

H9635_RS06065: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

H9635_RS06070: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

H9635_RS06085: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001103.5	0.45	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000207.5	0.43	PKS	chartreusin	Streptomyces chartreusis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001103.5	0.45	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000207.5	0.43	PKS	chartreusin	Streptomyces chartreusis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.15 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (2):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.34 out of 25.88

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ZuR variant 1	Zinc-responsive repressor

NZ_JACSPZ010000002.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 655,219 - 676,040 nt. (total: 20,822 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

H9635_RS06740: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

H9635_RS06745: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H9635_RS06760: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase

H9635_RS06755: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

H9635_RS06765: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000867.3	0.52	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000131.5	0.43	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000851.5	0.43	other (other)	albonoursin	Streptomyces noursei ATCC 11455
BGC0000207.5	0.42	PKS	chartreusin	Streptomyces chartreusis
BGC0002284.3	0.41	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001987.2	0.40	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001778.5	0.40	other (other)	showdomycin	Streptomyces showdoensis
BGC0002246.3	0.40	terpene	naematolin	Hypholoma sublateritium FD-334 SS-4
BGC0000631.5	0.39	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000867.3	0.52	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000131.5	0.43	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000851.5	0.43	other (other)	albonoursin	Streptomyces noursei ATCC 11455
BGC0000207.5	0.42	PKS	chartreusin	Streptomyces chartreusis
BGC0002284.3	0.41	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001987.2	0.40	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001778.5	0.40	other (other)	showdomycin	Streptomyces showdoensis
BGC0002246.3	0.40	terpene	naematolin	Hypholoma sublateritium FD-334 SS-4
BGC0000631.5	0.39	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

H9635_RS06780: PT_phytoene_like

Domain 1 (13 - 265): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.18 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.43 out of 26.06

Confidence: medium

Additional weak hits (1):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.26 out of 29.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
MogR	Repressor of flagellar motility genes

NZ_JACSPZ010000003.1 - Region 1 - NRP-metallophore,NRPS

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Location: 275,568 - 329,005 nt. (total: 53,438 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

H9635_RS08440: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H9635_RS08455: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H9635_RS08470: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: PPTase

H9635_RS08475: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

H9635_RS08465: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: cyclase

H9635_RS08545: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Isomerases: isomerase

H9635_RS08460: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

H9635_RS08490: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H9635_RS08500: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.73	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.65	NRPS	AM-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002135.2	0.68	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.11 out of 29.38

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.30 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.41 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.06 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.60 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.83 out of 26.33

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16

Confidence: strong

Additional weak hits (9):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.75 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.99 out of 32.74

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.43 out of 29.65

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.08 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.87 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.66 out of 33.14

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.62 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.07 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 275567 - 329005:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

H9635_RS08490: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (448..831): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISALELQALVGGEYNMYGPTETTIWSTC
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1464..1876): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H9635_RS08500: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..436): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: TLSLYPMSSPGGQLLVGGSQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (85% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_JACSPZ010000004.1 - Region 1 - terpene-precursor

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Location: 61,369 - 82,253 nt. (total: 20,885 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

H9635_RS09605: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: kinase

H9635_RS09595: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Ligases: synthase synthetase

H9635_RS09560: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

H9635_RS09565: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000638.3	0.40	terpene	carotenoid	Pantoea ananatis
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000663.5	0.39	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000630.3	0.39	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.38	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000638.3	0.40	terpene	carotenoid	Pantoea ananatis
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000663.5	0.39	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000630.3	0.39	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.38	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

H9635_RS09565: PT_FPPS_like

Domain 1 (33 - 293): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 21.55

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33

Confidence: medium

Additional weak hits (1):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.55 out of 32.93

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
ArcA	Repressor of carbon oxidation
MogR	Repressor of flagellar motility genes

NZ_JACSPZ010000005.1 - Region 1 - NRPS-like

Download region GenBank file

Download region SVG

Location: 53,030 - 95,987 nt. (total: 42,958 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase carbamoyltransferase

H9635_RS11955: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

H9635_RS11965: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

H9635_RS11905: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: cyclase

H9635_RS11980: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: ligase

H9635_RS11970: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

H9635_RS11895: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.61	NRPS	peramine	Epichloe festucae
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.61	NRPS	peramine	Epichloe festucae
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.90 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.21 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.34 out of 27.78

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.24 out of 27.78

Confidence: medium

Additional weak hits (4):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.21 out of 30.11

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 24.93 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.37 out of 36.53

Confidence: weak

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 53029 - 95987:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

H9635_RS11970: X

AMP-binding (11..418): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LYMAFDASVLDLVLGVGGEFNLYGPTEITVMATA
Nearest Stachelhaus code(s):: Phe DALVMGAVMK (53% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence
SypG	Regulator of biofilm formation and host colonization

NZ_JACSPZ010000008.1 - Region 1 - T3PKS

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Location: 51,202 - 92,284 nt. (total: 41,083 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

H9635_RS14850: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

H9635_RS14930: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: glycosyltransferase methyltransferase

H9635_RS14825: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

H9635_RS14845: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: hydrolase

H9635_RS14785: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

H9635_RS14830: hydrolase

smcogs: SMCOG1179: hydrolase

Ligases: synthase

H9635_RS14840: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

H9635_RS14920: Pseudouridine synthase

smcogs: SMCOG1154: Pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.68	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.49	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000802.5	0.48	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001226.4	0.41	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002496.3	0.41	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000243.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.68	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.49	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000802.5	0.48	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001226.4	0.41	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002496.3	0.41	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000243.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.82 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.54 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.61 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.94 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.70 out of 27.78

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.59 out of 32.93

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.46 out of 32.93

Confidence: medium

Additional weak hits (5):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.52 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.65 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.50 out of 29.38

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.01 out of 33.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.52 out of 30.11

Confidence: weak

Detailed domain annotation

Selected features only

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TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes