LOCUS       NZ_AP023440            24992 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces aurantiacus strain JCM 4677 chromosome.
ACCESSION   NZ_AP023440
VERSION     NZ_AP023440.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces aurantiacus
  ORGANISM  Streptomyces aurantiacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 9428393)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014701115.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 05:58:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,211
            CDSs (total)                      :: 8,122
            Genes (coding)                    :: 7,928
            CDSs (with protein)               :: 7,928
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 161 of 194
            Pseudo Genes (internal stop)      :: 17 of 194
            Pseudo Genes (multiple problems)  :: 48 of 194
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:48:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4033258
            Orig. end                         :: 4058250
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023440.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017557
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24992
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="19"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24992
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24992
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14992](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14992
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    68..83
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.99"
                     /tool="antismash"
     gene            112..843
                     /locus_tag="IGS71_RS16695"
                     /old_locus_tag="GCM10017557_34280"
     CDS             112..843
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971129.1"
                     /locus_tag="IGS71_RS16695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34280"
                     /product="hypothetical protein"
                     /protein_id="WP_055514266.1"
                     /transl_table=11
                     /translation="MYTQERTAMSNLVVGGPVAVNSYDNAIVAALLENRPVMLVHAFNG
                     GYLRPAELEKTIHDKGVELATTLDPDTKEAQGHLWYITPGGFFGQRPLYFIESAAGQVT
                     PPPAGTAEAETEAEAGRGDDGAPKPQRRRVTVHQDAPKDPNDAVRVGLPGEVGDKWRGK
                     NGAPEDTQLWVVTVTPWGGITFVPITHPDTILGFQDHTVTAKSQARLTYNWGGDFTGTV
                     INTFYPRLPSEWNVPYHHIFT"
     gene            911..2758
                     /locus_tag="IGS71_RS16700"
                     /old_locus_tag="GCM10017557_34290"
     CDS             911..2758
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955170.1"
                     /locus_tag="IGS71_RS16700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34290"
                     /product="FG-GAP-like repeat-containing protein"
                     /protein_id="WP_055514268.1"
                     /transl_table=11
                     /translation="MPVPAEELKLEIVNAATGQPLGARAVPSEDGALVVRDFPDDGPPP
                     ERWRITPAQNSQDDQAYVIRNAVGDKVLDGPAAADGGVRQGNAAADKQSQQWHVVPVEG
                     EAGLYFIEDVTDGAVLDLDDSGEDGEDGVRIVLREYDDSVASQRWRFVPAEPERISDPV
                     LRWAPLSHWNGRRSWRLAHSAALRPAPDATPSFSNVLLVLERFGSNKDAGEWSTVGSNR
                     SPSGLPGGWAGLGARFLADTTGDGWDIVGLKPGKGAVTSSGRGDGTFDDEERLLHQYAA
                     SASPQDLWTLTDTTGEGSLHVVVLAADGVRVSRQDEDGKDGAFAPAGGEPALKAFGHGP
                     QAGGWHADKHPRFLADTTGDDRLDIVGCHEDGVWISLQDEDGTFAPIGEEPVLRAFGHS
                     EDAGGWLAHEHPRFLADTTGNNRLDILGCHDDGVWISLQDEDGTFAEPLYVLDEFGVDQ
                     GWSSVQEHPRYLVRTTADGAVDIVGFGPHGVVVSRGRGDGTFEPAQLVLNDFGHTQGWT
                     GEKHLRLLADVTGDGNPDIVGFGDEGVWVSHNHDDGKFDQAQMVCRGFGHNDDAGAWRV
                     DHHPRFLADITGDGRVDIVGFGGPGVHVARNLFRRFRTR"
     gene            complement(3110..3667)
                     /locus_tag="IGS71_RS16705"
                     /old_locus_tag="GCM10017557_34300"
     CDS             complement(3110..3667)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177473.1"
                     /locus_tag="IGS71_RS16705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34300"
                     /product="GNAT family protein"
                     /protein_id="WP_055514270.1"
                     /transl_table=11
                     /translation="MYPVSRHSQRLELRELVLDDVAAVHEIYGSATATEHLSFEPRTLD
                     QVTQIVARSAASATAEPRTEYALAVVQRDTGDLIGFGRLATDPHQQRGATFGFALRPDT
                     WGKGYGLETVHLLLGLAFEELHLHRVWGARSPLNEASAKTMTAAGMVEEGVIRSHVQKA
                     GQWRDSVVHAIVDDEWAARQPT"
     gene            complement(3678..5030)
                     /locus_tag="IGS71_RS16710"
                     /old_locus_tag="GCM10017557_34310"
     CDS             complement(3678..5030)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003499.1"
                     /locus_tag="IGS71_RS16710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34310"
                     /product="hypothetical protein"
                     /protein_id="WP_245702352.1"
                     /transl_table=11
                     /translation="MVTFFRYWLDERELGAYEDFLPQFKKVAEGMGLRGLEPAKTTFHA
                     WYYGKRKPQGDSRRVLVSWANYSLETLWTEVPPGTVPTFPHLSSVSSLAHHADPIGMDM
                     INMKRTGAMAVQRAKEFLMGADRDSVGEDTLGLLGDEVVRLVGAYPRQPLSDIWGDLLT
                     TQDQIFRTLEGGRVRQPSKLRDLNYQAAVVSFLVAKGFNDLEDRAQAMTMTRVAAACAR
                     DAEHQGLMALVEGLRSLIAYWADKPTDAYHYAQRGVEMATNLNGTVKLWLLGLQSRAAA
                     VQSDAETARTASQQAGIWRESVELDDLDRLGGLFTYSEPKQLYYTVETEALLGNGDPRL
                     AAQAEDAVNSFSDPDTPFWAFGDLAGAQCNLALIRLHDGQLDGAAEAIRPVLELPTTHR
                     NNGIVVSAQRVRQALNSGPVRSAIQARSLREEIEIYPPQRSTGTSAIAPRE"
     misc_feature    5218..5231
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            5298..5792
                     /locus_tag="IGS71_RS16715"
                     /old_locus_tag="GCM10017557_34320"
     CDS             5298..5792
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075795.1"
                     /locus_tag="IGS71_RS16715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34320"
                     /product="ATP-binding protein"
                     /protein_id="WP_246596407.1"
                     /transl_table=11
                     /translation="MTSTMLLALRPAGAQAVPGASFRLLPREGLDVAFVRSSESMGGAI
                     AEEDRLWPQQMRRAVRAGLSRWNRPDITEAAELLVTELVTNALRHGRGDVRVRVHLATG
                     RVLIEVQDGSHEVAVPRNATPVDEDGRGLLLVTAIADDWGVSPDGTTTWCSLLLRDGTT
                     A"
     misc_feature    6034..6046
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.85"
                     /tool="antismash"
     misc_feature    6452..6466
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.07"
                     /tool="antismash"
     gene            6585..7112
                     /locus_tag="IGS71_RS40775"
                     /old_locus_tag="GCM10017557_34330"
     CDS             6585..7112
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039764.3"
                     /locus_tag="IGS71_RS40775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34330"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_055514272.1"
                     /transl_table=11
                     /translation="MSARWIAVQPLATRERGVKATTVGAASLRRAWPQTTRDVFASCHD
                     ADVSDEVAEVWGRAVHAGFDSTRIREGVRTAKSWKQAGVSPHPRTLVAVTRALTGYLTS
                     LVPYVSLHLETLTPGSRAWASCREAIERSHEARDAAPSEGVQAAGEHAFRLAVQTEVLL
                     RYAEQHTEQSGE"
     misc_feature    6666..6668
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7535..8452
                     /locus_tag="IGS71_RS16720"
                     /old_locus_tag="GCM10017557_34350"
     CDS             7535..8452
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662454.1"
                     /locus_tag="IGS71_RS16720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34350"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_246596408.1"
                     /transl_table=11
                     /translation="MPTNSLARPSSARIHNYLLGGRDNYTVDRTVAQRAAGKMPFLPSA
                     VRHERAYVLLMVQALAIAGIRQLVDFGCGMPHSPDPVDVITRVHPNARAVCIDGDALVH
                     AFTSALLRVGAPAAVAHLHADIREPESVLASREILKTINWREPVILLFGSVLHHIDDTP
                     ARPLSMLVDQYKKVAAPGSALVITHATADFAGKSARKAAKAMTAAGCPVYPRTKEQIAP
                     LFNDWHLVSPGLAEPQVMPLEHPVLPQTASYAGMARKGRLKTVVGDGVLPGPDQPFACT
                     ALGTLAPCQRPWQHRKHQPSNGNG"
     misc_feature    8318..8320
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8457..9662
                     /gene="fxlM"
                     /locus_tag="IGS71_RS16725"
                     /old_locus_tag="GCM10017557_34360"
     CDS             8457..9662
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138947.1"
                     /locus_tag="IGS71_RS16725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34360"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_190850825.1"
                     /sec_met_domain="PCMT (E-value: 1.7e-39, bitscore: 134.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALDGATVRNPDELRADMVRTLRDQDAITSEPVAAAFSAVPRHR
                     FAPEAPLSLAYDLHSTVPVKKDEHGLVLSVMSAAHLQAVMLEQAGIEPGMKVLEIGSGG
                     VNAAYLQELVGPGGEVTTVDIDRDIVERARLCLDEAGYTQVKTVVADGESGVPDGAPYD
                     RVIVTAAAWDIPPSWIGGLAEKGRLVVPLTVCGTTRSIAFDHDGDSLISRSYGLAHFVP
                     MQGEGAAEERKAMLRDGVVVRTDNVRVPLSAPALNRALDAPRLERWSGAAYDLPDELDL
                     YLTLNLSAVARLHADKEAIERRLVEASALLGVPALVSEDSIAYRTRRENEETGGYESGV
                     VAHGPQAEALADEYAHLLRRWAHDHRRRGAATFRYLPGPAPSPLPQNAVPRRHGIVTAT
                     WN"
     misc_feature    9712..9728
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            9732..9914
                     /locus_tag="IGS71_RS16730"
                     /old_locus_tag="GCM10017557_34370"
     CDS             9732..9914
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322874.1"
                     /locus_tag="IGS71_RS16730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34370"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_055514276.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3.5e-17, bitscore:
                     60.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQMEHPVTPAQSAAEQQDLTDFDLDITIVEGGPAADQLIRLTN
                     DGCNSTCATACVSCP"
     CDS_motif       9732..9845
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTVQMEHPVTPAQSAAEQQDLTDFDLDITIVEGGPAAD"
                     /locus_tag="IGS71_RS16730_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9846..9914
                     /prepeptide="core"
                     /locus_tag="IGS71_RS16730_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-1.70"
                     /molecular_weight="2180.5"
                     /monoisotopic_mass="2179.0"
                     /core_sequence="QLIRLTNDGCNSTCATACVSCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTVQMEHPVTPAQSAAEQQDLTDFDLDITIVEGGPAAD"
                     /leader_location="[9731:9845](+)"
                     /alternative_weights="2198.5"
     gene            10001..12901
                     /locus_tag="IGS71_RS41795"
                     /old_locus_tag="GCM10017557_34380"
     CDS             10001..12901
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123798.1"
                     /locus_tag="IGS71_RS41795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34380"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_055514278.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.4e-18,
                     bitscore: 65.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.4e-107,
                     bitscore: 358.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-25, bitscore:
                     88.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRYVDAAAVRASVWSPDQQTVWPDLTGPAANPAGWRAWLQLTWA
                     EEFTAAVAAASPDLASRVDQICAGRSLPEPAVRRTVLSVLRYLLRARTRATPFGLFAGV
                     AAARIDTAPALEVGARHRAVARPDAAHSTALVDRFEKHPVLRLHLMLLTSSLIVERDGH
                     LVIEHRPIGTREGTPERVQIRVTGPVREALGCARTPILWSDLVAKLSSSFLGASSSAIE
                     NLLAGLIEQRFLLTSLRPAMTATDPLAALLGHTQHLSPAEAADLRKPARTALDLRVDWN
                     LTIPESVALEAAAAAKALTRLAPRAALTGWAEWHGRFLERYGPRAVVPVVDAIDALGYP
                     SGYLGATTTSAPSPLPDRDSRLIKLAHTAGMQRRLEVDLDDAALEDLATTDPGLPVQPS
                     TEVTVRIDAASIPSLRQGEFTLHVVGVARSAGATTGRFLGMLDAEDRRRMTEVYASLSG
                     VHHGALVAQISSTPLSVRAENVARAPQATELVISLGDYHSTDTGLIPVTDLAVTADAGR
                     LHLVSLSRHRPVHTLLLNAVDLGRHTHPLARFLTEAPVALAVPCTGFMWGTAASSLPFL
                     PALRYGRTILSSARWLLASDDLPAVPVPWPQWDEALARWRREVHLPERVCLSEADQRLA
                     LDLAEPSHRVLLRTHLDRDGKVVLHPAPAPRDLGWTDGRAHEVVIPLAADQDVAPVRAG
                     GHVVGREHGHLPGCDNRIYLQLHGHRDRQNPLLTRRLPALLEELGGPRWWFVRYTDGGD
                     HLRVRLVCAPGTLGSAIERVGEWTRQLRLNGLITHASMETYHPESARFGGPTAIDAAEH
                     YFAADSAVAVAQLAAQSGKGAPDADAVTAASMVDIVTGLLGDTAAAMHWLIEHTLTNRA
                     APPRAVYRQAVDLVNAGPSRLDERVTTAWTMRRAALVTYRHALTGAALDPHDLLPDLLH
                     LHHVRMRGPGLPKERTHLHLARAAALSWTARARRTP"
     aSDomain        10460..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IGS71_RS41795_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.20E-20"
                     /identifier="RREFam001.1"
                     /label="IGS71_RS41795"
                     /locus_tag="IGS71_RS41795"
                     /protein_end="241"
                     /protein_start="153"
                     /score="65.0"
                     /tool="antismash"
                     /translation="SSLIVERDGHLVIEHRPIGTREGTPERVQIRVTGPVREALGCART
                     PILWSDLVAKLSSSFLGASSSAIENLLAGLIEQRFLLTSLRPA"
     misc_feature    10796..10798
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12898..14142
                     /locus_tag="IGS71_RS16740"
                     /old_locus_tag="GCM10017557_34390"
     CDS             12898..14142
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123797.1"
                     /locus_tag="IGS71_RS16740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34390"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_190850827.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-39, bitscore:
                     135.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTALVPTALSTADKLAHVLADPSTVWPRGRPDGGRAWPQSLAG
                     GASGIALLHIERARTGHGDWDTAHTWLTTTLRGDISAAANANLYFGAPALAFITHRAAS
                     ASSRYLRLLERLDAATCAVTRKRLAEAHQRIDRAERPPMEEFDLIQGLSGLGAYHLSRH
                     PHHEITRDVLVYLARLTEPLPDATGLPPWWMDVAPTGAPHADYPDGHGNFGLAHGIGSA
                     LSVLSLALLRDLTVPGTVEAVERICAWTDQWRQGNGTAPWWPGYISMRQATDRHVPSGL
                     RPRPSWCYGVGGTARAQQLAGLALRDPVRVQAAENAILATLRDPLQLDKLPEIGLCHGM
                     AGLLHAAWRMATETGNSEIAAELPRLANRLITALDQEDHDPELLDGAAGAALALHTLGT
                     GSAPAPHWDTFLAQA"
     gene            14162..14992
                     /locus_tag="IGS71_RS16745"
                     /old_locus_tag="GCM10017557_34400"
     CDS             14162..14992
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322883.1"
                     /locus_tag="IGS71_RS16745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34400"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_190850828.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.5e-30, bitscore:
                     103.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSPTWCQANVVFPDWERAESAALARLAPLLRSTEDEGALTAWFI
                     VRKHPCWRVRYQPVGGGQDRIGQGLDALIAEGHIKGWTEIVYEPEVHAFGGAEAMASAH
                     RLFHRDSRSIVDFLQGDSGRHRRETSLMLCSLMMRSAGLDWYEQGDVWARVGVHRALPA
                     GTARDSLDRLHPAVHRLISVNGEDMMRAGGPLVHAAEWAGAYINAGRELARLTDSGQLH
                     RGLRDVLAHHVLFAWNRIGLPYATQATLATAAKTAVFGLDPTTERSAADHVETP"
     misc_feature    14678..14680
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14976..16100
                     /locus_tag="IGS71_RS16750"
                     /old_locus_tag="GCM10017557_34410"
     CDS             14976..16100
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322865.1"
                     /locus_tag="IGS71_RS16750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34410"
                     /product="hypothetical protein"
                     /protein_id="WP_190850830.1"
                     /transl_table=11
                     /translation="MWKLPDTTVQRFPLVARPRPVCLPLPQRVLALVELADTAAQQGDP
                     SLASTVYNQAALIASDIGAPNTARAMCHQHTAAYLHAAPLTAKAAIRALEPVVNLARLQ
                     LRARRNEDSHQRLLALFDAVTTASPLKVEDIALPADLVANAADRQEVRAWLWSVLLADG
                     TRALTTAGRWTEALAHVETHRGIGQRMLDGRQVAVMAALTSGNSLGASILLAHTVPGKA
                     WEGSVTDCLSILCRCLSRQPWRRSLQNLVTTYLERPDQDDMVVFDTRLGLTVLDVVNSA
                     EDPATARKVVAELHRRTMKATDGYAARETLAHPLFTSLATDQEVRDSRALLHTCALGTG
                     MFPNELGEQLSAALRTSNHVIRRNTNYLQQAYVN"
     gene            16315..17817
                     /locus_tag="IGS71_RS16755"
                     /old_locus_tag="GCM10017557_34420"
     CDS             16315..17817
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS16755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_34420"
                     /product="hypothetical protein"
                     /protein_id="WP_190850831.1"
                     /transl_table=11
                     /translation="MRRPTLLYAVLEKRAWLRYEVFVTQLANAGARAATHYENPRLTRV
                     KTVTKTTFQRWLSGTQEPRGEAAVVIEFWLGYTVKELLGPAPERELVLARSLHDASLAA
                     AHSLDVKFDTSFLSVAAPAPGAGGVWHLDGLRILDGTAVAVQMYETALQPNCVVIGPED
                     LEHLRYFTQSRRRALLLGSLGAQGASDMYALDAAHARRQLAMPVQRLPIPIPYRLDYVT
                     YALLWAGLNVDDSLLADDRALHVEQQSLESHLEQGRSSAARTAYADLSNVGALWLGSRT
                     CAAFVHRHLNVGKVSSVMWSRMQFGEQAAAWLLFRERHGIQQLMQDRSFGLDGTPGCAL
                     CVPESAVHSSEPYERLLLLLAVALMESYGLNVWVCAEEDYSRLPEFHLGSDQRVIVADW
                     LDPDAVWNVESIGGRGATDAFAQAIHHAQVRSVASGATPHERIRALADYLGLSPEWAGL
                     VTRCRELGSYGTAGLLRTRSRLIHTGEIDRALQFLGGLGPAS"
     misc_feature    17383..17385
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18072..18085
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            18336..20093
                     /locus_tag="IGS71_RS16760"
                     /old_locus_tag="GCM10017557_34430"
     CDS             18336..20093
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="IGS71_RS16760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34430"
                     /product="ATP-binding protein"
                     /protein_id="WP_190850833.1"
                     /transl_table=11
                     /translation="MLSGKSFGVKQSWAVDTTSQISPYPVVSRTSMSEFASPARETPIT
                     VREGVRHRRRRKAPDKAARELSIRLIGLAVVPAAGMLLLMVAAVLSVAAAAPRERSAAS
                     VLIGAVAAGVLVLLLACRQALSTARGVEGDNQILAEWLEYLHKLVMAGEQEVRNSGTRL
                     RRGQRPLVASPAPPTKGAHTFVQLARALDAYRAAVGDAMTQAEGQRVQVFVNFSDRLKS
                     LGRAALHKLDEVERDVEDPDHLAALFGVDHDITRIRRAAESMAVMGGVKSSRSEDPAFV
                     KAVLRMGIQEIHNYARAKVVTACDASLPGYAVASVTHLLAELLENATAFSSPATQVEMR
                     ASLIPRGLLVEIDDKGLSMEPETFATMNDLLADPEHTEISAQLIAEGRNGLFVVASLAR
                     RYGITVTLRPNIYGGTQAVVIVPQALLDAGRQEMAEQQAARTSAPRDPQSRPQTAPPAH
                     HGTAPRATRASAPPGSVVQQRAPIRRPGGHVPAPVPSVHPETAALYLVDSGVQGGPGPL
                     PALPVRPDAPAPEANEKLPEPTQPGAATRRGVSRAEQQDWQLAAKFASGWQSAADDDGA
                     GPEPPAPAS"
     gene            20126..20545
                     /locus_tag="IGS71_RS16765"
                     /old_locus_tag="GCM10017557_34440"
     CDS             20126..20545
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015232.4"
                     /locus_tag="IGS71_RS16765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34440"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_055514290.1"
                     /transl_table=11
                     /translation="MTTDTPSGNMDLDWLLSNLVDTVPLASGAVVASSDGMLKHFYGVD
                     KDDADRLGAVATGAFALCGNVSRFFPDAGDAQGIQVLLETTVGLLFATRVGDNSVLAVL
                     GRKGVDVGQVGYEMRMLAKRAAPILATPARPAVAG"
     gene            20613..20918
                     /locus_tag="IGS71_RS16770"
                     /old_locus_tag="GCM10017557_34450"
     CDS             20613..20918
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017170.4"
                     /locus_tag="IGS71_RS16770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34450"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_157871425.1"
                     /transl_table=11
                     /translation="MNGGRTRPRLALARTTLVRARRTAQHPPQGSAERSAAFGWCQTQA
                     LTITEIAGRLRLPVQSVKVLVADLITEELLMTVATRQEDPKDPDVLERVLAGLQTL"
     gene            20896..21507
                     /locus_tag="IGS71_RS16775"
                     /old_locus_tag="GCM10017557_34460"
     CDS             20896..21507
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004990846.1"
                     /locus_tag="IGS71_RS16775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34460"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_245702354.1"
                     /transl_table=11
                     /translation="MQVFKPSEQPISQLKVVIAGGFGAGKTTLVARTSEIEPISTDEQL
                     TTAGIGTDRLDGVEAKTSTTVAFDFGRISLRSQNLDLYLFGTPGQARYQFMWNDIVDGA
                     IGAVVLADTRRLEDSFDPVNYFLRLGLPFIVGVNLFEGSARYPIERVREALRLDADVPV
                     VGCDARDSRSGRHVLITLVKHAHTRAVRARHTRPSTSLAD"
     gene            21525..22097
                     /locus_tag="IGS71_RS16780"
                     /old_locus_tag="GCM10017557_34480"
     CDS             21525..22097
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962512.1"
                     /locus_tag="IGS71_RS16780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34480"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_246596409.1"
                     /transl_table=11
                     /translation="MSDLTHTQRSLHAQTSQRLARLHQLGFADRPDEEFDRFSSALARD
                     SGVPGALAMVNAISDRQFFTGVHLPSAEELGSVAEAEALAAAVGRVMPLEHGYCPETMD
                     RTKPLTLPDVCMKPDFAGNEVVDLVGIRVYMGVRLIDKEMEIPLMTICVVGRERRPMKD
                     GRRMLDYIKQRGAQAQYLLDQRISALS"
     gene            complement(22128..23375)
                     /locus_tag="IGS71_RS16785"
                     /old_locus_tag="GCM10017557_34490"
     CDS             complement(22128..23375)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474467.1"
                     /locus_tag="IGS71_RS16785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_34490"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_246596410.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 7.8e-30, bitscore:
                     102.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.8e-16, bitscore:
                     58.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.7e-25, bitscore:
                     88.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVREVGGFGGLLREGLVFGCFTTERHDELRARVRAFGEAEVVPRI
                     PQWEQTRSVDHELIRRAAHLGWIGVTVDPVYGGMGAGHLAKTVLIEELARVSGAMGAAV
                     QASLIPVAMIINYGSEEQKTRWLPPIAAGTCLPTIAVTEKVSGSQITGIRGRARRKRGG
                     WLLSAEKTHVGNSHVADLHCVVVRSGPGRGGLSAFLVESQRPGVLVRPQVPAMGLNGFS
                     FGTVVLDEVWVPEDNLLGAVGEGEDAADSSSVLYGRANLAAVSLGVHRATVEEAMRFAE
                     KTERYGRPLNRLSTVEQRLGQMLANLEAAGVLAYTATDMLDRGLACDSPLMAAKLMNYE
                     LAVESARLAMEVHAACGVFADRPLERFFRDAHLIFAPAGTSDVQRLRLARLARGATAQG
                     QWSERFAAPAPSMMPV"
     misc_feature    complement(22752..22754)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23378..23391
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     misc_feature    24721..24734
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 ccacgggcca ttgaccttgc agttgcgtca cgtgcttaat cgtttcctga gcgccctgtg
       61 cgttgttctc ccgtattttt ctccgcttca agaacaggtg aggtttccgc gatgtacacc
      121 caagagcgca cggcgatgtc gaatttggtg gtcggcggtc cggtggcggt gaacagctac
      181 gacaacgcga tcgtggcagc gctgctggaa aaccggccgg tcatgctcgt ccacgccttc
      241 aacggcggat acctgcggcc cgccgaactg gagaagacaa tccacgacaa gggcgtcgag
      301 ctggcgacca cgctcgaccc ggacaccaag gaggcgcagg gtcacctctg gtacatcacc
      361 cccggaggct tcttcgggca gcggccgctg tacttcatcg agagcgccgc gggccaggtg
      421 acgcctccgc ccgccggcac ggcggaagcc gagaccgagg ccgaggccgg gcgcggcgac
      481 gacggcgcac cgaagccgca gcgcaggcgc gtcaccgtcc accaggacgc ccccaaagac
      541 ccgaacgacg ccgtccgggt cggcctcccc ggcgaggtcg gtgacaagtg gcgcgggaag
      601 aacggcgcgc ccgaggacac ccagctctgg gtcgtcacgg tgacgccgtg gggcggaatc
      661 actttcgtac ccatcaccca ccccgacacc atcctcgggt tccaggacca cacggtgacg
      721 gccaagagcc aggcgcgtct cacctacaac tggggcggcg acttcaccgg gacggtcatc
      781 aacacgttct acccgcggct gcccagcgag tggaacgtcc cgtaccacca catcttcacg
      841 tgacccgcgg ccaccatcgc gtcccatccg tcccgagcca acgcccgcac cgcctggaag
      901 aggcaccacg atgcccgtgc ccgcagaaga actgaagctg gagatcgtca acgccgccac
      961 ggggcagcct ctcggcgccc gggccgtgcc gagcgaggac ggggcgctcg tcgtccgtga
     1021 cttccccgac gacggcccgc ctccggaacg gtggcgcatc acccccgcac agaacagcca
     1081 ggacgaccag gcgtatgtga tccgcaacgc ggtcggcgac aaggtgctcg acggccccgc
     1141 cgccgcggac ggcggcgtcc gccaggggaa tgccgccgcc gacaagcaga gtcagcagtg
     1201 gcacgtcgtc cccgtcgagg gcgaagcggg cctttacttc atcgaggacg tgaccgacgg
     1261 cgctgttctc gaccttgacg actccggcga ggacggtgaa gacggcgtcc ggatcgtcct
     1321 gcgcgagtac gacgacagcg tggcaagcca gcggtggcgt ttcgtcccgg ccgagcccga
     1381 gcgcatcagc gaccccgtgc tgcggtgggc accgctgagc cactggaacg gccgccggtc
     1441 ctggcggctg gcccactcgg ccgcgctgcg gccggcaccc gacgcgacgc cctccttcag
     1501 caacgtactg ctggtgctcg aacggttcgg aagcaacaag gatgccggcg agtggagcac
     1561 cgtcgggtcc aaccgctctc ccagcgggct tccgggcggg tgggccggcc tcggagcgcg
     1621 gttcctcgcc gacaccacgg gagacggctg ggacatcgta gggctcaaac ccggcaaggg
     1681 ggccgtgacc tcgtccggca gaggcgacgg gacgttcgac gacgaggaac gcctcctgca
     1741 ccagtacgcg gcctccgcga gccctcaaga cctgtggacc ctcaccgaca cgacgggcga
     1801 gggcagcctg cacgtcgtcg tgctcgccgc cgacggagtc cgggtctccc gccaggacga
     1861 ggacggcaag gacggcgcgt tcgcgcccgc aggcggcgag ccggccctca aggcattcgg
     1921 ccacggcccg caagccggcg gctggcatgc cgacaaacac ccccgcttcc tcgccgacac
     1981 caccggtgac gacagactcg acatcgtcgg ctgtcacgag gacggagtct ggatctcact
     2041 ccaggacgag gacggtacct tcgcaccgat cggcgaggag cccgtcctcc gcgcgttcgg
     2101 ccacagtgag gacgcgggcg gctggctcgc ccacgaacac ccccgcttcc tcgccgacac
     2161 cacgggtaac aacaggctcg acatcctcgg ctgccatgac gacggagtct ggatctcact
     2221 ccaggacgag gacggtacct tcgccgaacc tctatacgtc ctcgacgaat tcggggtcga
     2281 ccaggggtgg agctcggtcc aggaacaccc ccgatacctg gtcagaacca ccgccgacgg
     2341 agctgtggac atcgtcggct tcggcccgca cggtgtcgtc gtctcccgcg ggcgcggcga
     2401 cggcacgttc gagcccgcgc aactcgtcct gaacgacttc gggcacaccc agggatggac
     2461 cggcgagaag cacctccggc tcctcgccga cgtcaccggc gacggcaatc cggacatcgt
     2521 cggcttcggc gacgagggcg tctgggtgtc gcacaaccac gacgacggca agttcgacca
     2581 ggcccaaatg gtgtgccgcg ggttcggcca caacgacgac gcgggcgcct ggcgcgtcga
     2641 ccaccatccc cgcttcctcg ccgacatcac cggcgacggc cgcgtcgaca tcgtcggctt
     2701 cggcggcccc ggcgtgcacg tggcccgcaa cctcttccgc cgcttcagga cccgataacc
     2761 gcgccccagc gctatggagg cgctattgag gtttctggca caggccttgg acagcgttca
     2821 cggagcctca cctcggtgct cgaattggag gagttgagaa gcgatggggc cgctcaattc
     2881 ctgtagcttc gcttctcggc catcgcactg gcagtggcga ggagcagcgt gacggtgacg
     2941 ccgtcagcga tcgcggctga ttccccaggt tcatcgccac ggcggccagg gccacggcga
     3001 ggcggcagcc caagccttcc acggcataca tgacggagca cgcagcggca tgcaccgtga
     3061 cggctcctcg tgatcgctcc agaacccaga gggcgtcgcc gtagccagat caggtgggct
     3121 gacgagcggc ccattcgtcg tcgacgatcg cgtgcacgac ggagtcccgc cactgcccgg
     3181 ctttctgaac gtgagaccga atgacaccct cctcgaccat ccccgcggcc gtcatggtct
     3241 tcgccgaggc ctcgttgagt ggagagcgtg caccccatac gcggtgaagg tgcaactcct
     3301 cgaaggccag gccaagcaga aggtgcacgg tctccaggcc gtagccctta ccccacgtgt
     3361 ccgggcgcag cgcgaagccg aaggtggctc cgcgctgctg gtgcgggtcg gtggcgagtc
     3421 ggccgaaccc gatcaggtcg ccggtgtccc gttggacgac ggcgagtgcg tattcggtcc
     3481 gtggctctgc ggtggccgag gccgccgacc gggccacgat ctgcgtgact tggtcgaggg
     3541 tgcggggctc gaacgacaga tgttccgttg ctgtggcact tccatagatt tcgtgcaccg
     3601 cggcgacatc gtcgaggacg agttcgcgca gttccaggcg ctggctgtgg cggctgaccg
     3661 ggtacatgcc ggggatgcta ctcgcgtggc gctatggcgg aggtgccggt ggagcgctgt
     3721 ggtgggtaga tttcgatctc ctcgcgcagg ctgcgtgcct ggatggctga gcggactggg
     3781 ccgctgttga gtgcctggcg aacacgctgt gcagacacga cgattccgtt gttcctgtgg
     3841 gtcgtgggca gttcgagcac gggccggatc gcttccgcgg cgccgtccag ctgcccgtcg
     3901 tggagacgga tgagtgcgag gttgcactgt gcgccggcca ggtcgccgaa cgcccagaac
     3961 ggggtgtccg gatcgctgaa agagttcacg gcgtcctctg cctgggctgc aagtcgcggg
     4021 tcaccgttgc cgagcagcgc ctcggtttcc acggtgtagt agagctgctt cggttccgag
     4081 taggtgaaca ggccaccgag gcggtcgagg tcgtcgagct cgacgctctc ccgccagatg
     4141 ccggcctgtt ggctggcggt gcgcgcggtt tccgcatcgc tttggactgc tgcggcgcgt
     4201 gattgcaggc cgaggagcca cagtttcact gtgccgttga ggttcgttgc catttccacg
     4261 ccccgctggg cgtagtggta ggcgtctgtg ggcttgtccg cccagtacgc gatcagtgac
     4321 cgcaggcctt cgacaagggc catgagtcct tgatgctccg cgtcgcgtgc gcatgcggct
     4381 gcgactcggg tcatcgtcat ggcctgggcg cggtcttcga ggtcgttgaa gcccttcgcc
     4441 acgaggaagg acaccaccgc ggcttgatag ttcaagtcgc gcagcttgga cggctgccgg
     4501 acccggccgc cttcaagagt acggaatatc tgatcttgcg tcgtgaggag atcaccccag
     4561 atgtcagaaa ggggctgccg cgggtaggcg ccgaccagcc ggactacctc gtcgcccagc
     4621 aggccgaggg tgtcttcccc cacactgtcg cgatccgcgc ccatgaggaa ttctttcgcg
     4681 cgctgcacag ccatcgcgcc cgtccttttc atgttgatca tgtccatacc gatgggatcg
     4741 gcatggtgtg ccagagatga cacactggac agatggggga aggtcgggac cgttcctggt
     4801 ggaacttctg tccacagggt ctcaaggctg tagttcgccc aggagacaag gacgcgccgc
     4861 gagtcgccct gcggtttacg cttgccgtag taccaggcgt gaaaggtcgt cttggcaggt
     4921 tccagacctc tcagccccat cccctcggcg accttcttga actgtgggag aaagtcctcg
     4981 taggcaccca actcgcgttc gtcgagccag taccggaaga acgtgaccac ttggtgcccc
     5041 catctccatc cattccgtgc atcacttcgt cgacagtaag ctgcttccct cctcaacttg
     5101 ccccattcag accgcactta acggtccgag gagaatccga gaaacagacg agaagctgcg
     5161 tcgtcgagcg gccaggaacc gagtagagga cggggctgga tccgcatcgc cacgactgaa
     5221 acgctcgtat ccagtcctcg cagagggtgc tggcacgagc acaatcgtgg aagcagaggt
     5281 atcccgtgag cccgcagatg acgagcacca tgctccttgc cctccgccct gcgggcgcgc
     5341 aggcagtacc cggagcctcc ttccgtctcc ttccacgcga gggccttgac gtggcttttg
     5401 tccgctccag cgaatccatg ggcggtgcca ttgcggaaga ggaccggctc tggccgcagc
     5461 agatgcggcg ggccgtccgg gccggattga gccgatggaa ccgaccagac atcaccgagg
     5521 ccgctgagct cctcgtcacc gagttggtta ccaacgcgct caggcacggt cgaggcgacg
     5581 tccgtgtgcg tgtgcacctc gccaccggcc gtgtcctgat cgaggtgcag gacggctccc
     5641 acgaggtcgc tgtgccgcgt aacgccacgc ctgttgacga ggacggccgc ggcctccttc
     5701 tcgtcaccgc catcgccgac gactgggggg tcagccccga tgggacgacg acctggtgct
     5761 ccctccttct gcgagatgga acaacggcat gaaactcgtc gtggtgccgg ccccggcccc
     5821 agacgactgg tccgccggcc ccctcccccg cccagaccga acgtctacac gctttcatga
     5881 agtatcaatt cagacgccca tttcccggca gagcaatgag tcatctcgga atgcacgtcg
     5941 ttttatggac acgtgagcgt gggcggggtc accgtccacc gatgagtaaa aagtcagtca
     6001 agtgcacggt cccactgtga agttagatca cgttcgcacc ttgcaattgg aacggggcgg
     6061 gtcgatagac ctggggtccg ctcgcgttcc acacggttgg atcttcttcg ttcgcggggt
     6121 gatgtggttg tgatgggtat gggcaacaga cactcctgca caccaggtga ccatcacgat
     6181 ccggcggcaa gcacatgcgc ggtgaagcgg taccgagggt acagccttgt ccaactcccg
     6241 gaacagctgc gcatcggcat gtcgaaccca tcgtcaacga caagatcgcg gagtcagaac
     6301 gaggtggaac attctgttcc gcccttcctc cgactggcac ctacggtgac aaaggatcgc
     6361 taccccgaac ctgccctcga aggaacgagc gaaaacttac gcaaccagcc ccggggtggc
     6421 catatcgctg gcccgggcca caagcagcct cactttttag aaactcgcct gattctatta
     6481 tttgtcggca ccccaagctt tatacgacgg taatcgccgg ctgtaccact gcgcaccgtc
     6541 gagtaaccaa tcccatgcca atcgatcgcc aaaggagtca gcccatgtcg gcgcgctgga
     6601 tcgccgtgca gccgctcgcc actcgggaga ggggagtgaa ggcaaccacc gtgggcgcgg
     6661 cttcgttacg ccgggcatgg ccacagacca cgcgagacgt gttcgccagc tgccatgacg
     6721 ccgatgtctc cgacgaggtt gccgaagtct gggggagggc agtgcacgcc gggttcgact
     6781 cgacacgcat tcgtgagggc gttcgcacgg cgaagtcgtg gaagcaggct ggggtgtctc
     6841 cgcacccccg caccctcgtg gcagtcacgc gtgcgctcac cggctacctc acgtcgctcg
     6901 tcccctatgt ctcgcttcat ttggaaacgc ttacccctgg aagccgcgcc tgggcctcgt
     6961 gtcgtgaggc gatagagcgc tcgcacgaag cgcgtgacgc tgctccgagc gagggtgtcc
     7021 aggcggcagg ggaacacgca ttccgtctcg cagtgcagac agaggtgctc cttcggtacg
     7081 cggagcagca caccgagcag agcggagaat gacgtggccc ggtcctacct tggtgctcgc
     7141 cacgggcgaa ctcgccgtgc ttctgctttt ccaccagcgc tgcgaaaaca cccggtggaa
     7201 gagatcactc cggggcgtgt tcgacgtggt ctgcggctgg cccgcgcaca ctggggcgct
     7261 ttctgcctcg gcgccgccat cagcatcaac gagggggcgc cacgcatacc cgacactgtc
     7321 tcgttcggcg tacttactga atggcatgcg gcggggaaac tggggcttca acagctggct
     7381 atgacgatca cggaaaccga acaccctttg tggttgggtg cgcccgatga cccggcccgg
     7441 tacatgcccg gcatccacac gcccttcggc ggggcggagc atcatgcgac ctgaccaccc
     7501 cctgctcctc gccccttccg acacacgtga tgtgatgccg accaactctc tggccaggcc
     7561 gtcgagcgcc cgaatccaca actacctgct cggcgggcgc gacaactaca ccgtggaccg
     7621 taccgttgcc caacgagccg ccggcaagat gccgttcttg cccagtgccg tccgccacga
     7681 gcgcgcgtac gtgctcttga tggtgcaggc tctggcgatc gcagggatca ggcagctggt
     7741 cgacttcggc tgcggcatgc ctcattctcc cgacccggtg gacgtcatca ctcgtgtgca
     7801 cccgaacgcg cgcgcagtgt gtatcgacgg cgatgccttg gtccacgctt tcaccagcgc
     7861 cctgttgagg gtcggcgcgc cagctgcggt cgcacacttg catgccgaca tccgcgagcc
     7921 cgagtctgtc ctggcctcgc gagagattct gaagacgatc aactggcgag agcccgtgat
     7981 cctgctgttc ggcagcgtgc tccaccacat cgacgacaca cccgctcgcc ctctgtcgat
     8041 gctcgtcgac cagtacaaga aggtcgccgc tccaggcagt gccctcgtga tcacgcatgc
     8101 cacggcggac ttcgccggca agtccgctcg caaggcggcc aaggccatga cggccgctgg
     8161 ctgccccgtc tatccacgga caaaagagca gatcgccccg ctgttcaacg attggcacct
     8221 ggtctccccg ggactggccg agcctcaagt gatgcccctg gaacacccgg tcctcccaca
     8281 gaccgcgtcg tacgcgggca tggcccggaa ggggaggtta aaaactgtcg tgggcgacgg
     8341 cgtactcccg ggtcctgacc agccgttcgc ctgtacagcc ctcggcacct tggctccatg
     8401 ccagaggccg tggcagcacc gcaagcacca accttccaac ggaaatgggt aatcggatga
     8461 ctgctcttga tggcgcgact gttcgcaatc ccgacgagct acgcgcggac atggtccgca
     8521 cactccgtga ccaggacgcg atcacgtccg agcccgtcgc agccgccttc tccgcagtgc
     8581 cccggcaccg gttcgcaccc gaagcacccc tgagtctcgc ctacgatctt cacagcactg
     8641 tgccggtcaa gaaggacgag catggcctgg tcctcagcgt catgtccgcc gcgcatctcc
     8701 aggccgtgat gctggagcag gccggcatcg agcccggtat gaaggtcctg gagatcggct
     8761 ccggtggcgt caacgcagcg tacctccagg aactcgtggg acccggcgga gaagtcacca
     8821 ccgtggacat tgaccgcgac atcgtcgagc gtgcccgcct gtgcctggac gaagccggat
     8881 acacccaggt gaagacagtc gtcgccgatg gcgagagcgg cgtccccgat ggcgccccgt
     8941 acgaccgggt catcgtcacc gcggccgcct gggacatccc cccgtcgtgg atcggcggac
     9001 tcgccgagaa gggcaggctc gtcgtcccac tgacggtgtg cggcaccacc cgctcgatcg
     9061 ccttcgacca cgacggtgac agcctgatca gccgctccta cggcctggcg cacttcgtgc
     9121 ccatgcaggg cgaaggcgcc gccgaggaac gcaaggcgat gctgcgggac ggcgtcgtcg
     9181 tgcggaccga caacgtacga gtgcccctca gcgccccggc cctgaaccgt gccctggacg
     9241 ccccccggct ggagcgctgg tcgggcgccg cctacgacct gcccgacgaa ctggacctgt
     9301 acctcacgct caacctgtcc gccgtcgccc ggctgcatgc ggacaaggag gccatcgagc
     9361 gccgactcgt cgaagcttca gccctgctcg gcgtacccgc cctcgtcagc gaggacagca
     9421 tcgcgtaccg cacccgccgc gagaacgagg agaccggcgg ctacgagagc ggcgtggtcg
     9481 cccacggccc gcaggccgaa gccctcgcgg acgagtacgc gcatctgctc cgccgctggg
     9541 cccacgacca ccgccgccga ggagctgcga cgttccggta cctgccgggt cccgccccct
     9601 cccccctgcc ccagaacgcc gtaccgcggc gccacggcat cgtcacggcg acctggaact
     9661 aagccccccc gacccgtctc cgggcccggg gaccacgcac catcattcaa ctgcccctga
     9721 aggaggcacg catgaccgtt cagatggagc accctgtcac gcccgcgcag tcggccgccg
     9781 aacagcagga cctcaccgac ttcgacctgg acatcaccat cgtcgaaggc ggtcccgccg
     9841 ctgaccagct catccgcttg accaacgacg gctgcaactc cacgtgcgcg accgcgtgcg
     9901 tgagctgccc gtaagcagca ccgagccgcg ttcaccgcgg tgcccggccg gcacctgctc
     9961 cacgagggcg gccgggcacc gcgcagccac aggagggcgt gtgtatcgct acgttgacgc
    10021 agcagcggtc cgggcgtccg tgtggagtcc agatcaacag actgtctggc ctgatctgac
    10081 cggcccagcc gcgaacccgg cagggtggcg ggcatggctg cagctgacct gggcggagga
    10141 gttcaccgcc gccgtcgcag ccgccagccc ggacctcgcg agccgagtgg accagatctg
    10201 tgccggccga tcgttgcccg aacccgccgt gcgccgcacg gtcctctccg tcctgcgcta
    10261 cctgctgcgc gcacgcacac gcgccacccc gttcggtctg ttcgccggag tcgcggcagc
    10321 ccgcatagac accgcgcccg cactggaggt aggcgctagg caccgcgccg ttgcacgacc
    10381 ggacgcggcc cacagcactg ccctcgtcga ccgcttcgag aagcacccgg tgctgcggct
    10441 ccacctgatg ctgctcacct ccagcctgat cgtcgaacgc gacggacact tggtgatcga
    10501 gcaccgcccc atcggaacac gcgaaggcac ccccgagcgc gtacagattc gcgtgacggg
    10561 accggtccgt gaagccctcg gctgcgcacg gaccccgatc ctgtggagcg acctcgtcgc
    10621 aaagctctcc agcagcttcc tgggcgcctc ctccagcgcg atcgagaacc tgctcgcggg
    10681 cctgatcgag caacgctttc tgctcaccag cctccgcccg gcgatgacgg ccaccgaccc
    10741 actcgccgcc ctcctcggtc acacacagca cctctccccc gccgaggcag cagacttacg
    10801 taaacctgcg aggaccgcgc tcgacctgcg ggtggactgg aacctgacca tccccgagtc
    10861 cgtggccctg gaggcggcag cggcggcgaa ggcactgacc cgcctcgcgc cccgtgcggc
    10921 gctgaccgga tgggccgagt ggcacggccg gttcctggaa cgttacgggc cgcgggcagt
    10981 cgtccccgtc gtggacgcca tcgacgccct cggatacccg tccggctacc tgggcgccac
    11041 cactacctcc gccccctccc cactacccga tcgcgatagc cgactcatca aacttgccca
    11101 caccgccgga atgcagcgcc gccttgaagt cgacctcgac gacgccgctc tggaggacct
    11161 ggccaccacg gatcctggcc tccccgtcca accgagcacc gaagtgaccg tccgcatcga
    11221 cgcagccagc atcccgtccc tgcggcaggg cgagttcacg ctgcatgtcg tcggggtggc
    11281 acgctcggcc ggagcgacca ccggccgctt cctgggcatg ctggacgccg aggaccgccg
    11341 ccgtatgacc gaggtgtacg cgtcactgtc cggagtgcac cacggcgcgc tcgtcgcgca
    11401 gatcagctcc accccgctgt ccgtacgcgc cgagaacgtc gcgcgcgccc cgcaggcgac
    11461 cgagctggtg atctctctcg gcgactacca cagcacggat accggcctca tccccgtgac
    11521 agaccttgcg gtgaccgcgg acgccggacg gctgcacctg gtctcactct cccgccaccg
    11581 cccggtgcac acgctgctgc tgaacgccgt cgatctgggc cgccacacgc atccactggc
    11641 ccgattcctg accgaggcac cggtcgcgct ggctgtcccg tgcaccggat tcatgtgggg
    11701 caccgcggcc tccagcctgc cgttcctgcc cgcactccgt tacggccgca cgatcctgtc
    11761 ctcggctcgc tggcttctcg ccagtgacga cctcccggcc gttccggtgc cgtggccgca
    11821 gtgggacgag gccctggctc gatggcgccg cgaggtgcat ctgcccgagc gggtgtgtct
    11881 gagcgaagcc gaccagcgcc tggccctgga cctggcggag ccctcacacc gggtcctgct
    11941 gcgcacgcac ctggaccgcg acgggaaggt ggtcctgcac cccgcaccgg caccccggga
    12001 cctgggctgg accgacggcc gtgcccacga agtcgtcatc cccctggccg cagaccagga
    12061 cgtggccccc gtccgtgcgg ggggccacgt cgtcggccgc gagcacggcc acctgcccgg
    12121 ttgcgacaac cgcatctatc tccagctcca tgggcaccgc gaccggcaga acccgctcct
    12181 gacccggcgc ctgccggccc tgctggaaga actgggcggc ccccgttggt ggttcgtccg
    12241 ttacaccgac ggcggggacc accttcgcgt tcggctggtc tgcgcgcccg gcacactcgg
    12301 ctccgccatc gaacgcgtcg gcgagtggac gcgccagctt cggctcaacg gcttgatcac
    12361 ccacgccagt atggagacct accacccgga atcagcgcgg ttcggcggtc ccaccgcaat
    12421 cgacgcggcc gagcactatt tcgccgccga ctccgccgta gccgtggccc agcttgccgc
    12481 ccaaagcggg aagggcgcgc cggacgcaga cgcggtgacc gccgcgagca tggtggacat
    12541 cgtcacgggt ctgctcggcg acaccgccgc ggcgatgcac tggctcatcg agcacaccct
    12601 caccaaccga gccgctccgc cccgcgccgt ctaccgccaa gccgtcgatc tggtgaacgc
    12661 cggcccatcg cgcctggacg aacgcgtgac cacggcctgg accatgcggc gcgcggcact
    12721 ggtcacctac cgccacgcgc tcacgggcgc ggccctggac ccacacgacc tgttgccgga
    12781 cctgctgcac ctccaccacg tccggatgcg cgggcccggg ctgcccaagg agcgcacgca
    12841 cctgcatctg gccagagctg ccgcactgag ctggacggca cgagcaagga ggacaccgtg
    12901 accacgacag ccctcgtccc cactgcgctg tcgaccgccg acaagctggc ccacgtactg
    12961 gccgacccga gcaccgtgtg gccccgcggc cggcccgacg gcggccgggc ctggcctcag
    13021 tcgctcgccg gcggcgcctc aggcatcgcc ctgctgcaca ttgagcgcgc ccgtaccggc
    13081 cacggcgact gggacaccgc tcacacctgg ctgaccacca ccctgcgcgg cgacatcagc
    13141 gcggcggcca acgcgaacct gtacttcggt gctcccgccc tcgcgttcat cacgcaccgc
    13201 gcggccagcg catcgagccg atacctccgc cttctggaac gtctggatgc ggcgacctgc
    13261 gccgtcaccc ggaaacgcct ggcagaggcc caccaacgca tcgaccgcgc cgaacggccc
    13321 cccatggaag agttcgacct gatccagggc ctgtcaggcc tgggcgccta ccacctgagc
    13381 cgtcatcccc accacgagat cacccgtgac gtcctggtct atcttgcgcg cctgaccgag
    13441 cccttgcccg atgcgaccgg actgccgccg tggtggatgg acgtcgctcc caccggcgca
    13501 ccccacgccg actaccccga cgggcacggg aacttcggtc tcgcccacgg aatcggctcc
    13561 gccctgtccg tactctccct ggccctgctg cgcgacctga ccgtgcccgg cacggtcgag
    13621 gcagtcgaac ggatatgtgc ctggaccgac caatggcgtc aaggcaacgg gaccgcgcct
    13681 tggtggccgg gctatatctc aatgcggcag gcgaccgacc gccacgtccc ttccggcctt
    13741 cgcccccgcc cgtcctggtg ctacggagtc ggcggcaccg cccgcgccca gcagttggcc
    13801 ggactcgccc tccgagaccc tgtgcgcgtg caggccgccg agaacgcgat cctcgcgacc
    13861 ctgcgcgacc cgcttcaact ggacaagctc cccgagatcg ggctgtgcca cggcatggcc
    13921 ggactgctgc atgccgcgtg gcggatggcc acagagacgg gcaacagcga gatcgctgcg
    13981 gagctgccac gcctggccaa ccgcctgatc accgcactcg accaggagga ccatgacccg
    14041 gaactcctcg acggtgcagc cggagcagcc ctcgccctgc acaccctcgg cacaggcagc
    14101 gcgcccgcac cgcactggga caccttcctc gcccaggcgt gaacacgacg gagaccccct
    14161 catgaactca cccacctggt gccaggccaa cgtcgtgttc ccggactggg agcgtgccga
    14221 gagcgccgcc ttggcccgac tcgccccgtt gctacgcagt acagaggacg aaggcgccct
    14281 caccgcgtgg ttcatcgtcc gcaaacaccc ctgctggcgc gtgcgctatc agcccgtcgg
    14341 cggcgggcag gaccgcatcg gccagggcct cgacgcgctc atcgccgagg ggcacatcaa
    14401 agggtggacg gagatcgtct acgaacccga agtccatgcc ttcggtggcg ctgaagccat
    14461 ggcgtccgcg caccgactct tccaccgcga cagccgcagc atcgtcgact ttctccaggg
    14521 cgactccggc agacaccgtc gcgagacctc gctcatgctg tgcagcctca tgatgcgctc
    14581 cgcaggactg gactggtacg agcagggcga cgtctgggca cgcgtcggcg tgcatcgcgc
    14641 gctgcccgcc ggtaccgcac gggacagcct ggaccgctta catccagccg tgcaccgact
    14701 gatctctgtg aatggagagg acatgatgcg cgcgggtgga ccgctggtcc acgcggccga
    14761 atgggccggc gcttacatca acgccggaag ggaactggcc cgcctcacag actccggaca
    14821 gcttcaccgt gggctgcgtg acgtcctggc ccatcacgtg ctcttcgcct ggaaccggat
    14881 cggcctgccc tacgccacgc aggccaccct cgccaccgcc gcgaagaccg ccgtcttcgg
    14941 cctcgacccc accaccgaga ggagcgccgc agaccatgtg gaaactccct gacaccacag
    15001 tccaacgctt ccccctcgtc gctcgccccc gccctgtctg ccttcctctg ccccagcgcg
    15061 tgctcgccct ggtcgaactc gccgacaccg cggcgcagca gggcgacccg agcctggcct
    15121 ccaccgtcta caaccaggcc gccctgatcg cctccgacat cggcgccccg aacaccgccc
    15181 gcgcgatgtg ccaccagcac accgccgcct acctccacgc cgcgcccctg accgcgaagg
    15241 ccgcgatccg cgccctcgaa cccgtcgtca acctcgcgcg tcttcaactc cgcgccaggc
    15301 gtaacgagga cagccaccaa cggctcctcg cgctgttcga cgccgtcacc accgcaagcc
    15361 ccctgaaggt cgaggacatc gccctaccag cggacctggt agcgaacgcc gccgaccgtc
    15421 aagaggtccg cgcctggctg tggagcgtcc tgctcgccga cggcacacgc gccttgacca
    15481 ccgccggccg ctggaccgaa gcactcgcgc acgtagagac gcaccgcggc atcggacagc
    15541 gcatgctcga cggccgccaa gtcgccgtca tggccgctct cacgagcgga aacagcctcg
    15601 gcgccagcat cctcctggcc catacagtgc cgggaaaggc atgggaggga tccgtcaccg
    15661 actgcctgag catcctgtgc cgctgcctgt caaggcagcc ttggcgacgc tccctgcaga
    15721 acctggtgac cacttacctc gaacgtcccg accaggacga catggttgtc ttcgacacga
    15781 ggctcgggct gaccgtgctg gacgtggtca actcggccga agacccggcc accgcgcgca
    15841 aggtggtcgc agagctgcac cgccggacga tgaaagcgac cgacggctac gccgcccgcg
    15901 agaccctggc gcacccgctg ttcacctccc tcgccaccga ccaggaggtg cgggacagcc
    15961 gtgcactcct ccacacctgc gcactcggaa cagggatgtt ccctaatgaa ctgggcgagc
    16021 aactctccgc cgcactacgc acgagtaatc acgtcattcg ccggaatacc aactatctac
    16081 agcaggctta cgtaaattga acataactga tcttgcgcag tccgcggtca ctgtcggtcg
    16141 agtaggcgcc tgccgcatga ctgagcgcca tacccctact ccgacggcag aactccataa
    16201 cggcgggcgg tcggccagcg ccattgaacg cacgcacagc tatattccga ttccggacac
    16261 caaatgccct ctgacacatc tcaaactttc caccacccaa aggagaagag agtcatgcgt
    16321 cgcccgacgc tcctctacgc cgtgctggaa aagcgagctt ggctacgcta cgaagtattc
    16381 gtgacgcagc ttgccaatgc aggtgctcgg gcggccacac actatgaaaa tccacgcctg
    16441 accagggtga agactgtcac caagaccacg ttccagcggt ggctgtccgg cacacaggaa
    16501 ccgcgcggtg aagcagctgt cgtgatcgag ttctggctcg gctacaccgt caaggaactc
    16561 ctcggtccag caccggagcg agagctcgtg ctcgccagga gccttcatga tgcctcgctc
    16621 gctgccgcgc acagtctgga cgtcaagttc gatacctcat tcctgtcggt tgcggccccg
    16681 gcgccgggcg ccggcggcgt ctggcacctg gacggtctga ggatcctcga cgggactgcc
    16741 gtcgcggtcc agatgtacga gacagcactt caacccaatt gtgtggtgat cgggccggag
    16801 gacctggaac acctgaggta cttcacccaa tcgaggcgca gggcattgct ccttggatcc
    16861 ctgggcgccc aaggtgccag cgatatgtac gcattggatg ctgcgcacgc tcgccgccaa
    16921 ctcgcgatgc ctgtgcagcg gctgcccatc cccattccgt accgactcga ctacgtgaca
    16981 tacgccttgc tgtgggccgg cctgaacgta gacgacagcc ttctcgccga cgaccgtgcc
    17041 ctccatgtcg agcagcaaag cctcgaaagc cacctggaac aggggcgctc ttctgcggcc
    17101 agaactgcgt atgcggatct ttccaacgta ggagccctat ggctcggctc tcgcacctgt
    17161 gcggcattcg tccaccggca tctgaacgtc ggcaaggtaa gttccgtcat gtggtcacga
    17221 atgcagttcg gtgagcaggc ggcggcctgg ctcctgttcc gtgagcgcca cggcattcag
    17281 cagctcatgc aggaccgctc cttcggcctg gacggaacac ctggctgcgc cctgtgcgtg
    17341 cccgagtcgg ccgtgcacag tagcgaaccg tatgagcggc ttttattgct gctggccgtt
    17401 gcgttgatgg agtcgtacgg gctgaacgtc tgggtctgcg ctgaggagga ttactcccgg
    17461 ctccccgagt tccaccttgg atcggatcaa cgcgtcatcg tggccgactg gctggatcct
    17521 gatgcggtct ggaacgtcga aagcatcggc ggtaggggtg ccaccgacgc cttcgcacag
    17581 gcaatccacc acgcccaggt tcggagcgtc gccagcggtg ccacgcccca cgaaaggatc
    17641 cgcgcgctcg ccgactacct cggcctcagt cccgagtggg ccgggctggt aacgcgctgc
    17701 cgtgaactgg gctcatacgg aacggccggc ctgctgcgga cgcgcagtcg cttgatccac
    17761 actggtgaga tcgacagggc cctgcagttt ctcggcgggc tcggccctgc ctcctgagga
    17821 ccagcaatgg cggcgcccgc ctaaagcgtc tgggcctgat gacatctctc ggtttcgcgg
    17881 cgaaattcag ggttccgttc atcatgtgtg actgtcgaaa atcatgaacc tccgtcgctc
    17941 agtcccggtc cgctgtcagg aactgtctgt gctcctgccg gtcgatccat gctcggatgt
    18001 tgcggagtcc agttttcgag gtaaatcgtt tccgtgtcgc tcggcacgcc tcgttctcgt
    18061 tccggacgtc gattcattca taaaagtctg attccgactc gtccagcacc ccgcgtacat
    18121 cctgaacgac tcacgaacga ctgtttttgg tgtggcgccg accggttgaa ccgagcaagc
    18181 tgttgttcct cctgatgccg ccggaagcag attttcctgc gggaccgtgg ttactggccg
    18241 gcgaagctgc tcgctcggcc tcggcgttgt ggtggccttt gacgtcgtgg gcctcacccc
    18301 gacgatcagt gtcttgacgc cgttgccctg gcctcgtgct gagtgggaag tccttcggcg
    18361 tcaagcagtc atgggctgtc gacacaacat cccagatctc gccctaccct gtcgtttcga
    18421 ggacatcgat gtctgaattc gcttcgcccg cccgggaaac tccgatcacg gttcgggagg
    18481 gagtccggca tcgtcggcgt cgcaaggctc ccgacaaagc tgctcgtgag ctgagtatcc
    18541 ggctgatcgg gctggcggtt gttccggctg cgggcatgtt gctgctgatg gtggccgccg
    18601 tcctgtccgt tgcggcggct gctcctcggg agaggtcagc cgcatccgtg ctcataggtg
    18661 ccgtggcggc aggtgtcctc gtgctcttgc tggcgtgtcg tcaggcgctg tccactgccc
    18721 ggggggttga gggcgacaac cagattcttg cggagtggct ggagtacctg cacaagctgg
    18781 tgatggccgg agagcaagag gtccgcaatt ccgggacccg gctccggcga gggcagcgcc
    18841 ctctcgtcgc ttcacctgcg ccgccgacga agggtgctca cacgttcgta cagctggcgc
    18901 gtgctctgga cgcctaccgg gcggcagtgg gcgatgcaat gacgcaggca gagggtcagc
    18961 gggtgcaggt gttcgtcaac ttctccgacc gcctgaagag tctgggccgg gcggcgctgc
    19021 acaagctgga cgaggtcgag cgggatgtcg aggacccgga ccatttggcg gcgctgttcg
    19081 gtgtggatca cgacatcact cgcatccggc gcgccgcgga gagcatggcg gtgatgggcg
    19141 gcgtcaagtc ttcacgcagc gaggacccgg cgttcgtcaa ggccgttctg cggatgggga
    19201 tccaggagat ccacaactat gcgcgggcga aggtggtcac cgcgtgcgac gcgagccttc
    19261 cggggtatgc cgtggcctcc gtcacccacc tgttggcgga gctgctggag aacgccaccg
    19321 ccttctccag tcccgccacg caggtggaga tgcgtgcctc gctgatcccc cgcgggctcc
    19381 tcgtggagat cgacgacaag ggcctgagta tggagcccga aaccttcgcc acgatgaacg
    19441 acctgctcgc cgaccccgag cacaccgaaa tcagtgcgca gttgatcgca gaaggccgca
    19501 atggcctgtt cgtcgtggcc tcgctcgccc gccggtacgg catcaccgtc accctgcggc
    19561 cgaacatcta cggcggtacc caggcggtcg tgatcgtgcc ccaagcgcta ctggacgccg
    19621 gccgacagga gatggccgaa cagcaggctg cccggacgtc agcccccagg gatccccagt
    19681 cccggcccca gacggcacca cctgcacacc acggcaccgc acctcgcgcc acccgggcct
    19741 cagcacctcc ggggtccgtc gtccagcagc gcgcgcccat caggcggccc ggcggacacg
    19801 ttcccgcccc tgtgccgtcg gttcacccgg agacagccgc gctgtacctg gtcgacagcg
    19861 gtgtgcaagg cgggcccggg ccgctgcctg cgcttcccgt acgccccgac gcccctgctc
    19921 ccgaggcgaa cgagaaactg ccggagccga cgcagccggg agccgccacg cgtcggggtg
    19981 tctctcgggc cgagcagcag gactggcagt tggcggccaa gttcgccagt ggatggcagt
    20041 ccgctgcgga cgacgacggc gcaggaccgg agccaccggc ccccgccagc tgacccccac
    20101 cctttgatcc aaggagacga tcaccgtgac gaccgatacc cccagcggaa acatggacct
    20161 ggactggctg ctgtccaacc tcgtcgacac tgtccccctg gcgagcggcg cagttgtggc
    20221 gtcctcggac ggcatgctca agcatttcta cggtgtggac aaggacgatg cggaccggct
    20281 gggcgcggtg gccaccggag cgttcgcgct gtgcggcaac gtgagcaggt tcttccctga
    20341 cgccggggat gcccagggga tccaggtgct gttggagacg accgtcggac tgctcttcgc
    20401 cacacgggtc ggcgacaaca gtgtgctggc ggtcctcgga cgcaaggggg tggacgtggg
    20461 ccaggtcggc tacgagatgc ggatgctggc caagcgggcc gcaccgatcc tggccacccc
    20521 ggcgcggccc gccgtggccg gctgagatgt cgccctccga ccacgctgcc cgggcacccg
    20581 gcagcggtcc gccacggata cgcccgtaca ccgtgaacgg cgggcgcacc cgcccgcgtc
    20641 tggcattggc gcgcaccacg ctggtcaggg cacgccgcac cgcccagcac ccgccccagg
    20701 ggtcggcgga acgctctgcc gcgttcgggt ggtgccagac ccaggccctc acgatcaccg
    20761 agatcgccgg gcgtctgcgg ctgccggtgc agtcggtcaa ggtcctcgtt gccgacctga
    20821 tcaccgagga gttgctgatg accgtcgcca cccgccagga agatcccaaa gaccctgatg
    20881 ttctggagag agtccttgca ggtcttcaaa ccctctgaac agccgataag ccagctgaag
    20941 gtcgtcatcg cgggcgggtt cggcgctggc aagaccacac tggttgcgag gacgagcgag
    21001 atcgaaccga tctcgaccga cgagcagttg accaccgcgg ggatcggtac ggaccgtctc
    21061 gacggtgtgg aggccaagac cagcaccacg gtggccttcg atttcggccg tatcagcctt
    21121 cgtagccaaa accttgacct ctatctgttc ggcaccccgg gccaggcgcg ctaccagttc
    21181 atgtggaacg acatcgtcga cggcgcgatc ggcgccgtgg tcctggccga cacccgtcgt
    21241 ctggaggact ccttcgaccc cgtcaattac ttcctgagac tggggctgcc cttcatcgtc
    21301 ggggtcaacc tgttcgaagg ctcggcccgc tacccgatcg aaagagtccg cgaagcgctc
    21361 cgtctcgatg cggacgttcc agtcgtcggg tgcgatgcac gcgactcacg ctcgggccgc
    21421 catgtgctga tcaccctcgt caagcacgcc catacccgtg ccgtccgcgc acgtcacact
    21481 cgcccctcga cctccctggc cgactgacac cgtacggagt cctcgtgtct gacctcacgc
    21541 acacccagcg cagcctgcac gctcaaacct cccagcgcct ggcgcgactg catcagctcg
    21601 gcttcgccga ccgtcccgac gaggagttcg accgcttcag cagtgctctg gcccgcgact
    21661 ccggcgtccc gggggccctg gcgatggtca acgccatctc ggaccggcag ttcttcaccg
    21721 gcgtgcacct tccctccgcc gaggaactgg gttccgttgc cgaggccgag gctctggccg
    21781 ctgctgtggg acgtgtgatg cctctggagc acggctactg ccccgagacc atggaccgga
    21841 cgaagcccct cactcttccc gacgtgtgca tgaagcccga cttcgccggc aacgaggtcg
    21901 tcgacctggt cggaatccgc gtctacatgg gggtgcgcct gatcgacaag gagatggaga
    21961 ttcctctcat gacgatctgc gtcgtcggcc gcgagaggcg cccgatgaag gacggacgtc
    22021 ggatgctcga ctacatcaag caacgcggag cgcaggccca gtaccttctc gaccagcgca
    22081 tctccgcgct gtcctagctc acaccggcat cactgcacgg ccatgagtca cacaggcatc
    22141 attgacggcg cgggggcagc aaatcgctcg gaccactgcc cttgcgccgt cgcaccccgc
    22201 gcgagccggg ccagccgcag ccgctgcacg tccgaggtcc cggccggcgc aaagatcagg
    22261 tgggcgtcgc ggaagaaccg ctccagcggc cggtcggcga acacaccgca cgcggcatgg
    22321 acctccatgg ccaaccgcgc cgactccaca gcgagttcat agttcatcag cttcgccgcc
    22381 atcagcggac tgtcgcacgc cagaccacgg tccagcatgt cagtcgccgt gtaggcgagg
    22441 actccggccg cctccaggtt ggccaacatc tgccccagtc gctgctccac cgtactgagc
    22501 cggttcaagg gcctgccgta gcgttccgtc ttctccgcga agcgcatggc ttcctccacg
    22561 gtcgcccggt gcacgccgag tgagaccgcg gccagattgg cccgcccgta caggacgctg
    22621 gaggagtcgg ccgcgtcctc gccttcaccc accgccccga gtaggttgtc ttccggcacc
    22681 cacacctcgt ccagtacgac ggtgccgaag gagaagccgt tcagtcccat cgccggcact
    22741 tgcgggcgca ctaaaacccc tggccgctgg ctctccacca aaaacgccga caagccgcct
    22801 cgccccgggc cactacgcac gacgacgcag tgcaggtcgg cgacgtggct gttgcccaca
    22861 tgtgttttct ccgcactcag cagccatcca ccccgcttgc gacgggctcg gcctcgtatg
    22921 ccggtgatct ggctaccgga gaccttctcg gtcacggcga tggtgggaag acacgtgccc
    22981 gccgcgatcg ggggcaacca cctcgtcttc tgttcctcac tgccatagtt gatgatcatg
    23041 gctactggga taagggacgc ctggaccgcg gcgcccatcg cgccgctcac ccgggccagt
    23101 tcttcgatga ggaccgtctt cgcgaggtgc cccgcgccca tcccgccgta cacgggatcg
    23161 acggtgacgc ctatccaccc caggtgagca gcccgccgga tcagctcgtg atcgacactt
    23221 cgtgtctgct cccactgagg tatgcgaggc accacctcgg cctcgccgaa cgcccgcaca
    23281 cgagcccgca gctcatcgtg gcgctccgtg gtgaagcaac cgaacaccaa gccctccctc
    23341 aacaggcccc caaagccgcc gacctcgcgc accacggcgc atgcacaggc acggcgccca
    23401 ggaccgacca cggcttcctc gcccaccggg cagatggaca gccccggcga acacggcctc
    23461 acaccacccg gccccgaaga cgaggcagca cagacgagac cgcctcttta ccgtgacgat
    23521 ttatcgcctt cgccgcatca ccgctggtgg atcgttcaga catcgtttgc cctacgagcc
    23581 agaccagccg agtcatctga ggagccgaaa aggggcagtt tgctcggctc cctcggtcag
    23641 agcctcgctc caacgaccac tgaacgatcc cgccaaccgg tggcagcgat cacggacttc
    23701 ggccagagtg atggccgccc agggcgaacc gtccggtcaa ccccgcctgg catggaggtt
    23761 ggtcctgcgg caccttggcg gtccgctccc gtaggtgtct cccccgtcgc tcgcgggagc
    23821 ggatcccaac agagcggcac agacttcttc ccctaccaaa agggcagcag tcacctcacc
    23881 agccactcca ccgcccgttc ccaccccagc caggaagccc gacaacacat gagccgccgc
    23941 gaatccgccc cgacccccaa ggcctcatcg tcgaagattc cggactgcgg atcctcttcc
    24001 cggccgaccc gaatgtctca gtgccctggc cgccggctct cagcacagcg cgcgccagac
    24061 ggaccatggc tctgaccacg ccgtccgccg tgtatgccgt cgtgaccgtt cggccctgct
    24121 ctgccagaaa tagtcagcgt caaaggggtg atcatgaaga cgcgtcgtct catcagggtc
    24181 gtcagctgca acttcgagcg caacggtggc ggcgaccgcg aaaagtggct ggccatgcac
    24241 cagcgtctgg ccagcttgtg ccccacgatc ctgtgccggc aggaaaaccc cggtcatgct
    24301 cgtagcggag cgggctcaac ccttttcaac gagtccaagc gcattttgag tttggccggc
    24361 gagctcggtc ctgggctggg cgccacagcc ctgtactacg acccggagat ctttgagcag
    24421 atcaccatgt gggacaccaa gtggccgggc tggctcctgc atcccgtcgc gatgacgctg
    24481 cggctgcgcg gcaccgcgga cgtcgacttc gttgcgggct gcacccatct gtcgtacaac
    24541 tccccctcgc tccgggcagg ccaggcggag gacgtcaccc ggttcgccga tcgcgtcgag
    24601 acatacaaaa cgagcaccgg caccatcgaa cgaaagctgc ccgttctcgc gatcggccag
    24661 gacagcaaca gttacgtcga ccccgaccat cttgtccccg gcgaagcccc catccccgaa
    24721 ctcacgcaga tcaaggatgc gacgcaccga gctcaccgca gctacgagat cgcccccggc
    24781 cagcgggtca tggactccca gccttatcgg accctgcgga tcgccgagtt ggacgacgtc
    24841 gcccgacgcg ccgcactcct gccccacggc gggggcctag ccgcagttgc cccgaccgtc
    24901 gacgcgtcgc ggacccacgg cccggctcat cgcgttgatt ttgtattcac cagccggatg
    24961 ctcctgcccg ccctgatcaa ggtcgaggtc at
//
