LOCUS       NZ_AP023440            21128 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces aurantiacus strain JCM 4677 chromosome.
ACCESSION   NZ_AP023440
VERSION     NZ_AP023440.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces aurantiacus
  ORGANISM  Streptomyces aurantiacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 9428393)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014701115.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 05:58:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,211
            CDSs (total)                      :: 8,122
            Genes (coding)                    :: 7,928
            CDSs (with protein)               :: 7,928
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 161 of 194
            Pseudo Genes (internal stop)      :: 17 of 194
            Pseudo Genes (multiple problems)  :: 48 of 194
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:48:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3148487
            Orig. end                         :: 3169615
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023440.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017557
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="17"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11128](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11128)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(725..742)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.84"
                     /tool="antismash"
     gene            1095..2057
                     /locus_tag="IGS71_RS12805"
                     /old_locus_tag="GCM10017557_26280"
     CDS             1095..2057
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973710.1"
                     /locus_tag="IGS71_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26280"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_055520271.1"
                     /transl_table=11
                     /translation="MTASSTRRTTAAQSRIAAVGAIAVAGALLLTGCGDQTEDKDSGGS
                     DSASTSSAPLADQLPKAVRDKGVIKVGSDIAYAPVEFKDDSGKTVGIDPDLADAMGKQL
                     GVKFEFENGTFDTLLTGLRSKRYDIAMSAMTDTKDRQEGIDADTGKKVGEGVDFIDYFT
                     AGVSIYTKQGDDQGIKTWEDLCGKKVVVQRNTVSNDLAKAQAKECPSGKKLSIEAFDND
                     QQAQTRLRAGGADAGSSDFPVAAYAAKTSGGGKDFEVVGEQVEAAPYGIAVAKSNTELS
                     KALQAALDAIIKSGEYDKIIAKWGVEAGAVKEATLNGGK"
     gene            2091..3035
                     /locus_tag="IGS71_RS12810"
                     /old_locus_tag="GCM10017557_26290"
     CDS             2091..3035
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136634.1"
                     /locus_tag="IGS71_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26290"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_055520272.1"
                     /transl_table=11
                     /translation="MTVDIDKTAGPESTPPGGPEAIKAIPVRHYGRYVSAVIAIAIFVA
                     IVYAFAQGKINWGAVPDYFFDDRILKGVGQTMLLTVLSMLIGIAGGILLAVMRLSKNPV
                     TSSIAWFYIWFFRGTPVLVQLVVWFNLGLVFEYINLGPVYKDEWSSFMTPLLTALLGLG
                     LNEAAYMAEICRAGLLSVDEGQTEASHALGMSHGKTLWRIVIPQAMRVIVPPTGNEVIN
                     MLKTTSLVSVVQFAELFRYAQDIGQSSGAPVEMYFLAAAWYLVLTSVLSVGQYYVERYY
                     ARGSSRALPATPFQKIRANVLSLSNRSGRGANA"
     gene            3032..3835
                     /locus_tag="IGS71_RS12815"
                     /old_locus_tag="GCM10017557_26300"
     CDS             3032..3835
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571391.1"
                     /locus_tag="IGS71_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26300"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_342671094.1"
                     /transl_table=11
                     /translation="MTSNVTKADAVPGSGTPMVKAEGVHKSFGPVEVLKGIDLEVRPSE
                     VFCLIGPSGSGKSTFLRCINHLEKVNAGRLYVDGELVGYRQKGDKLYELRDSEVALKRR
                     DIGMVFQRFNLFPHMTALDNVMEAPVQVKGVSRAEARERAAQLLQRVGLADKAGSYPSQ
                     LSGGQQQRVAIARALAMEPKLMLFDEPTSALDPELVGDVLDVMRDLAESGMTMVVVTHE
                     MGFAREVGDSLVFMDEGVVVESGHPRDVLTNPQHERTQSFLSKVL"
     gene            complement(4155..4913)
                     /locus_tag="IGS71_RS12820"
                     /old_locus_tag="GCM10017557_26310"
     CDS             complement(4155..4913)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657871.1"
                     /locus_tag="IGS71_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26310"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_055512793.1"
                     /transl_table=11
                     /translation="MTTTLGSDWHAWQESWDRQQEWYMPDREERFRVMLDMVEALVGPE
                     PRVLDLACGTGSITARLFERFPKAVSTGVDLDPALLAIAEGTFAGDDRVTFVTADLKDP
                     DWPSRLPYDSYDAVLTATALHWLHSEPLTVLYGQVAGLVRDGGVFMNADHMIDETTPRI
                     NAADRARRHALMDGAKAAGVLDWAEWWQLAAQDPVLAEPTARRFEIYGEHADGDTPSAE
                     WHARALRGAGFAEARGVWRSPSDALVLALK"
     gene            5012..5641
                     /locus_tag="IGS71_RS12825"
                     /old_locus_tag="GCM10017557_26320"
     CDS             5012..5641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326935.1"
                     /locus_tag="IGS71_RS12825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26320"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_055512795.1"
                     /transl_table=11
                     /translation="MELAYYSDYAVRLVNSEEPARGTDTLTSVDAIRDLFGGNASAARR
                     ATDSDVTRFRGVRARLRAVFEAADTDDETLAVDLLNSLLLEFPVSPQISGHDIRDDNGR
                     PLWHMHLADHPSNATAGYAAIAAMGLAFHLTEYGVDRLGLCEAAPCRNAYLDTSTNRSR
                     RYCSDRCATRANVAAYRARKRLEADRPESTGRAADSSQRASANGER"
     gene            complement(5545..5979)
                     /gene="sodX"
                     /locus_tag="IGS71_RS12830"
                     /old_locus_tag="GCM10017557_26330"
     CDS             complement(5545..5979)
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016485 - protein processing [Evidence
                     IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sodX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925778.1"
                     /locus_tag="IGS71_RS12830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26330"
                     /product="nickel-type superoxide dismutase maturation
                     protease"
                     /protein_id="WP_055512796.1"
                     /transl_table=11
                     /translation="MPELSQETERGRAVLPFGTAEVTGPSMVPTLHHGDLLVVQYGARV
                     RPGDVVVLRHPFQQDLLVVKRAAERREGGWWVLGDNTYAGGDSTDYGTVPEELVLGKVR
                     FRYRPRKKGQRSPFALARWLLSAARPVLSGRSASRRFRAR"
     gene            6125..6520
                     /gene="sodN"
                     /locus_tag="IGS71_RS12835"
                     /old_locus_tag="GCM10017557_26340"
     CDS             6125..6520
                     /EC_number="1.15.1.1"
                     /GO_function="GO:0004784 - superoxide dismutase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sodN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313646.1"
                     /locus_tag="IGS71_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26340"
                     /product="superoxide dismutase, Ni"
                     /protein_id="WP_055512801.1"
                     /transl_table=11
                     /translation="MLSRLFAPKVKVSAHCDLPCGVYDPAQARIEAESVKAVQEKMGAN
                     DDAHFQARATVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKA
                     STDPATGQKALDYIAQIDKIFWETKKA"
     gene            6718..7131
                     /locus_tag="IGS71_RS12840"
                     /old_locus_tag="GCM10017557_26350"
     CDS             6718..7131
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559754.1"
                     /locus_tag="IGS71_RS12840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26350"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_055512803.1"
                     /transl_table=11
                     /translation="MTTEDLVRLRKARDRMDREYAEPLDVSMLARTALMSPGHFQRSFR
                     AAFGETPYGYLMTRRIERAKALLRRGDLSVTEVCLAVGCTSLGSFSSRFTELVGRTPSA
                     YRAESHEPGAAIPACVAKMYTRPVRRAAAKPLA"
     gene            7136..7549
                     /locus_tag="IGS71_RS12845"
                     /old_locus_tag="GCM10017557_26360"
     CDS             7136..7549
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953514.1"
                     /locus_tag="IGS71_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26360"
                     /product="VOC family protein"
                     /protein_id="WP_055512806.1"
                     /transl_table=11
                     /translation="MDLKISQCFISVDDHDRALAFYRDVLGLEVRNDVGFEGMRWVTVG
                     PPLQPDVEIVLEPPLADPNAPEEDRRAVAELLAKGLLRGVIFTTENCDATYERLLAADA
                     DILQEPMDQPYGVRDCAVRDPAGNLLRFTQRKG"
     misc_feature    complement(7160..7173)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(7564..8832)
                     /locus_tag="IGS71_RS12850"
                     /old_locus_tag="GCM10017557_26370"
     CDS             complement(7564..8832)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058267.1"
                     /locus_tag="IGS71_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26370"
                     /product="DUF6596 domain-containing protein"
                     /protein_id="WP_055512808.1"
                     /transl_table=11
                     /translation="MSGPPRRPSGRTTEIEGLLRQHAPQVLGALVRRYGHFDSAEDAVQ
                     EALLAAAGQWPESGVPENPRGWLIKVASRRLTDVLRSEEARRLREERAAALTPRDAFTA
                     PPPGAARAPSEDDTLTLLFLCCHPDLTPPARIALTLRAVGGLTTAEIARAHLMPEATMA
                     QRISRAKQKVKGASFGRPENWEERLPTVLHVLYLIFNEGYTATSGTALQRAELAGEAIR
                     LTRTTHQLLPGSHEVTGLLALMLLTDARRAARTGPHGELVPLGEQDRTLWDKAAIEEGV
                     ALVTGALTQRGPGPYQGPGPYQLRAAIAAVHDEAASPDDTDWQEILGLYDILVGLVPGP
                     VERLNRAVAVAMVHGPQAGLAALAPLEAELATGHRLDAVRAHLLERAGDTEAARAAYES
                     AADKTLSLPEQHYLRTRAARLRP"
     gene            complement(8829..9242)
                     /locus_tag="IGS71_RS12855"
                     /old_locus_tag="GCM10017557_26380"
     CDS             complement(8829..9242)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384635.1"
                     /locus_tag="IGS71_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26380"
                     /product="YciI family protein"
                     /protein_id="WP_055512810.1"
                     /transl_table=11
                     /translation="MKYLVMIQGTQADYEAQAGKGSAGAPAWTEQDMQAMFAHMSAINN
                     DLAETGEMVDGNGLTPPAQARFVEPGPDGKPVITDGPYSETKEVLAGYWVLDCVSLERV
                     TEIVGRILESPVPEGTQRYPVVIRPLFDGGGDV"
     gene            complement(9428..9691)
                     /locus_tag="IGS71_RS12860"
                     /old_locus_tag="GCM10017557_26390"
     CDS             complement(9428..9691)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998007.1"
                     /locus_tag="IGS71_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26390"
                     /product="hypothetical protein"
                     /protein_id="WP_190850249.1"
                     /transl_table=11
                     /translation="MASDESVCPVCKQPVDMVVRRHKTLGVFVPVWGSGPCRNPRCASY
                     EEGEESGRPEVKPASAASEAGPVPMAEPGQPREPRATMERDS"
     misc_feature    complement(9683..9701)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            complement(10001..11128)
                     /locus_tag="IGS71_RS12865"
                     /old_locus_tag="GCM10017557_26400"
     CDS             complement(10001..11128)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984437.1"
                     /locus_tag="IGS71_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26400"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_190850250.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.5e-58, bitscore:
                     195.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFMTETRQNLLPAVEGPGPHHGSVPVGRHGPPDGQEAAVILER
                     ARTSVDPELRRAVESLPGSMRRIALYHFGWQHADGTPAAANAEKAGKAIRPALVLAAAG
                     ALGGHRATAVRAAAAVELVHNFTLLHDDVMDRDTTRRHRPTAWAVFGDADAVLAGDSLQ
                     ALAHRLLAEDPHPASSAAAARLASCVVELCAGQHADTAMERRCPDDITLDEVLAMAEAK
                     TGALLGCACALGALYAGADDADVEALDAFGREAGLAFQFIDDVIGIWGDPRRTGKPAGA
                     DLMARKKSLPVVAALASGTPAGAELAELYRVPYRDGDLGRTILAVERAGGRDWAQAQAA
                     ERMARALDHLSRAVPDPEEAGGLLSLAEFVTRRNT"
     misc_feature    complement(11090..11092)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11247..12653)
                     /locus_tag="IGS71_RS12870"
                     /old_locus_tag="GCM10017557_26410"
     CDS             complement(11247..12653)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136651.1"
                     /locus_tag="IGS71_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26410"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_190850251.1"
                     /transl_table=11
                     /translation="MSVGEEIRADQDQPQKSLGTSAARNLATTTKSVPQMQEISSRWLL
                     RMLPWVNVQGGTYRVNRRLSYSVGDGRVTFVKTGDRVQVIPAELGELPALRTYEDQEVL
                     SELAQRCEQREFGPGDVLASFGSPAEEVFLLAHGRVEKVGTGPYGDDAVLGVLADGSYF
                     GDQAITDPDAIWEYTARAATACTVLTLPRADLDQIAERSESLREHLERLRTIPEQRSNP
                     YGEKEIDLAAGHTGEPAIPGTYVDYDAAPREYELSVAQTVLRIHTRVADLYNQPMNQTE
                     QQLRLTVEALKERQEHELVNNREFGLLNNCEYDQRLQPHDGVPSPDDLDELLTRRRGTK
                     LLLAHPRAISAFGRELNRRGLVPETLDVAGHRIPTWRGVPMFPCNKIPVTEARTTSIIA
                     MRTGEAEQGVVGLQQAGIPDEIEPSLSVRFMGISEQAIMSYLVTTYYSAAVLVPDALGV
                     LENVEIGRWR"
     gene            12889..13122
                     /locus_tag="IGS71_RS12875"
                     /old_locus_tag="GCM10017557_26420"
     CDS             12889..13122
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535203.1"
                     /locus_tag="IGS71_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26420"
                     /product="hypothetical protein"
                     /protein_id="WP_055512813.1"
                     /transl_table=11
                     /translation="MAGFLDRAKEQAQRGITQGKQKIDDVQAQRAGSDLLKSLGAAYLA
                     ERRGSGSPQATQQALQAVESHIATHGDSFLRS"
     gene            13292..13870
                     /locus_tag="IGS71_RS12880"
                     /old_locus_tag="GCM10017557_26430"
     CDS             13292..13870
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030135.1"
                     /locus_tag="IGS71_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26430"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_190855227.1"
                     /transl_table=11
                     /translation="MSASSFLSRLKAEGITVVEVGDWEHHNRNHKGPWGQVHGVMIHHT
                     VTSGRRRTVEICRDGYSGLPGPLCHGVITKDGRVHLVGYGRANHAGLGDDDVLRAVIAE
                     KALPADNEANTDGNRHFYGFECENLGDGKDPWPEAQLEAIERAAAAVCRHHGWTERSVI
                     GHLEWQPGKIDPRGFTMAAMRARIRDRLK"
     misc_feature    13334..13348
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    13481..13483
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13948..14907
                     /locus_tag="IGS71_RS12885"
                     /old_locus_tag="GCM10017557_26440"
     CDS             13948..14907
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480404.1"
                     /locus_tag="IGS71_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26440"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_246596366.1"
                     /sec_met_domain="PALP (E-value: 1.4e-16, bitscore: 59.6,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPDTPDAVALGVLRPRLPSPLQEVVDERFERRGVRLLLKRDDL
                     IHPELIGNKWRKLAPNLLAARGRTVLTFGGAYSNHLRATAAAGRLLGLPTVGVVRGQEL
                     ADRPLNPSLARCAADGMRLHFIDRSTYRRKSDPATLAALRRATACEDAYVIPEGGSNAL
                     AVRGCTALGEELRGHADVVALACGTGGTLAGLAGGLSPGQRALGIPVLRGGFLGAEIRA
                     LQEAAFGGPRGDWSLDDRFHFGGYARTPPELDALAADFGRRHDLPVERLYVAKSLYGLL
                     TLTQEGVFPRGTTVAAVITGSPDDTVQVGPKSQVGTSD"
     misc_feature    14713..14715
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14904..16499)
                     /locus_tag="IGS71_RS12890"
                     /old_locus_tag="GCM10017557_26450"
     CDS             complement(14904..16499)
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984441.1"
                     /locus_tag="IGS71_RS12890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26450"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_190850253.1"
                     /transl_table=11
                     /translation="MHVMPLLLLIAGSAAVAGAARRTPVPAPLLLVAAGLVVSYVPGVP
                     EYTLDPHIVLPLLLPPLLYTAATDSSYLDLRAQLRPVALLSVGYVLFATLAVGWAAYVL
                     VPDLSLTAALVLGAVVAPPDAVAATAVARRVGLPSRVTTILQGESLVNDATAITAYKVA
                     LAAAVGEGATWAGGIGEFLLAALGGIGVGLVLMVPIHWMRTRLNEALLQNSLSLLTPFF
                     AYAVAEQVHASGVLAVVVVALYLGHRNWEVDFATRLQEEAVWKMVAFILESAVFALIGL
                     QLPVILKGLGAYEGASAVWYAVALFGIVVLTRFAWVYPATFLPRLLSARIREREANPTW
                     KGPFIISWAGMRGVVSLAIAFSIPLTVEGGEDFAGRDLILFLTFTTVIGTLVVQGLSLP
                     PLIRLLKLPARDQQAETLAEANAQAQASRAAEQRLEELLSDERNTLPPPLAVRLRAVLE
                     RRRNAVWERLGQVNTVTGETADDTYRRLSREMIGAERAVFVKLRNGRYIDDEMLRTLLR
                     RLDLEEAAAFREAT"
     gene            16561..16821
                     /locus_tag="IGS71_RS12895"
                     /old_locus_tag="GCM10017557_26460"
     CDS             16561..16821
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571357.1"
                     /locus_tag="IGS71_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26460"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_055512817.1"
                     /transl_table=11
                     /translation="MKQCTHADALPPTEPAPLSDTCLECQAAGSHPVQLRLCLDCGHVG
                     CCDSSQLRHATEHFKETGHPIMRTFEPGESWRWCFVDHVLV"
     misc_feature    complement(16929..16942)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.89"
                     /tool="antismash"
     gene            17073..17486
                     /locus_tag="IGS71_RS12900"
                     /old_locus_tag="GCM10017557_26470"
     CDS             17073..17486
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966375.1"
                     /locus_tag="IGS71_RS12900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26470"
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_055512819.1"
                     /transl_table=11
                     /translation="MSQIAGEPATQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLIDDSLEVTVSAPTTDGHAPARDTFAWTV
                     LSALAGKVSSSVADDKTVSISLYKQRGAGPGPA"
     gene            17504..18628
                     /locus_tag="IGS71_RS12905"
                     /old_locus_tag="GCM10017557_26480"
     CDS             17504..18628
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136656.1"
                     /locus_tag="IGS71_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26480"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_246596367.1"
                     /transl_table=11
                     /translation="MRDEERGTRELPAGGENGPGGPRHLAEGVDGIPEQQARPHPEDDS
                     SPAAGVSRGEPIGKDEREALSGSDGRQDPDVAAQWGSPRTESGGTSLEGRRRVTGGIMS
                     EQHEHERNAENGASGTQHDPHNRSGARLKFIELRKLDHDSPEYAELRNQLVRMHLPLVE
                     HLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPERGVEFSTYATPTVVGEIKRHFRDKG
                     WAVRVPRRLQELRLALTTATAELSQQHGRSPTVHELAEKLGISEEEVLEGLESANAYST
                     LSLDVPDTDDESPAVADTLGSEDEALEGVEYRESLKPLLEDLPPREKRILLLRFFANMT
                     QSQIAQEVGISQMHVSRLLARTLAQLREKLLVEE"
     gene            complement(18787..19236)
                     /locus_tag="IGS71_RS12910"
                     /old_locus_tag="GCM10017557_26490"
     CDS             complement(18787..19236)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437926.1"
                     /locus_tag="IGS71_RS12910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26490"
                     /product="hypothetical protein"
                     /protein_id="WP_190850255.1"
                     /transl_table=11
                     /translation="MSSEQNPTPETVDAEPRPGRLTVAAALAALEGLALAAGGVYLLVM
                     GFTGHPDDRRQAVTGGVTLIVLALLPLLAARGLLLRRSWSRGPTIITQIMALPVAYNLL
                     QADSLAIPGGIALAVVAVVTLVLILNPETTRALGITGPGGVREPE"
     gene            19374..20342
                     /locus_tag="IGS71_RS12915"
                     /old_locus_tag="GCM10017557_26500"
     CDS             19374..20342
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010353615.1"
                     /locus_tag="IGS71_RS12915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26500"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_055512823.1"
                     /transl_table=11
                     /translation="MRALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARD
                     LGRQAAESKDIELVVALGGDGTVNEVVNGLLHNGPDPDRLPGLAVVPGGSTNVFARALG
                     LPNDAVEATGALLDALREGRERTVGLGLAAGTPGSDDEGVPARWFTFNAGLGFDAGVVG
                     RVEQHRERGKRSTHSLYVRQAMRQFFGETHRRRGTITLERPGSDPVTDLVLSIVCNTSP
                     WTYLGNRPVYASPKASFDTGLDVLGLSRMSTAAVARYGTQLLTSSPERGPHGKHAVSLH
                     DLTDFTLHSKVPLPLQMDGDHLGLRTSVAFTGVRRALRVIV"
     misc_feature    complement(20432..20441)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     misc_feature    complement(20601..20616)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    20604..20615
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            20660..20917
                     /locus_tag="IGS71_RS12920"
                     /old_locus_tag="GCM10017557_26510"
     CDS             20660..20917
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563321.1"
                     /locus_tag="IGS71_RS12920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_26510"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_016639615.1"
                     /transl_table=11
                     /translation="MDWRHNAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQ
                     CLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQASA"
ORIGIN
        1 ccgccgaagg acggcgcgag ccgcacgacg gtctcgacga tctcgtcgac gcccgtgcag
       61 tccagcgcga tcggcacggc gtcgaccccg ccgaactgct tgaacaggat cgccttgccc
      121 tccatcacgg ggagcgaggc ctcggggccg atgtcgccga gcccgagaac ggcggttccg
      181 tccgtcacga cggcgaccac ggacgacttc cacgtgtagt cgtggacgag ttccggctgc
      241 tccgcgatgg ccaggcagac cttcgcgacg ccgggcgtgt acgccaggga caggtcgtcc
      301 ctgtcacgga cgggcacggt ggcctgcacg gccatcttgc cgccacggtg cagcgcgaac
      361 gccgggtcga aggaatcgag gggctcggcc ccgccgtcct gatccgtact gctgtcgctg
      421 cgaggattga cgatctccgc tgccactttg ttttacccct taagtcttaa cggttgaggg
      481 tcgccgctcc tggtgaggag cgggcgggca ccgcgcatgt ccctgatgac tgttgagtgc
      541 ggaacatgcg cgacgggcgc gccgcacacg cgccctgagc cccggatgag gggtgtaagg
      601 aaccttctta ccggacggac cgcaccgcgg acgagtccgt ggagcgtcca tggcgcgaag
      661 gtcacatatg ggccgccgaa ggccgcgttc cggtggcccc ggactcgtat accggagcgt
      721 gaaggtcaca taccggtgac atgactcatg tccgaatgta cgagacaagg ccatttcacg
      781 aataagtcac ccacaagtgc cagaacatcc gaagtacccg gatgtggtcg ctcgctcggc
      841 ggaatccacc ggagatcttc cggtcctcgc ggaggttttc cgcacaagat ccggtccggc
      901 cggactactc cggtccggtt cgggggtcac ccgttatccg attttgacat ggcgggcacc
      961 ctgaaggacc gagtccgaat ggcaagatgc cctaatcaca cgaggtcgcg acacccgaag
     1021 gtgtgtgttc tcgtcgaccc atcggctact gccgacccat cggcaactcc acccacccgc
     1081 cggaggaacc caccatgacc gcaagctcca cccgtcgtac caccgccgcg cagtcccgga
     1141 tagccgcggt cggtgcgatc gcggtcgcag gcgccctgct gctcaccggc tgcggtgacc
     1201 agaccgagga caaggacagc ggcggctccg actccgcgag caccagctcg gccccgctgg
     1261 ccgatcagct gcccaaggcc gtccgcgaca agggcgtcat caaggtcggc tcggacatcg
     1321 cgtacgcgcc ggtcgagttc aaggacgact ccggcaagac ggtcggcatc gacccggacc
     1381 tcgcggacgc gatgggcaag cagctcggcg tgaagttcga gttcgagaac ggcaccttcg
     1441 acaccctgct caccggcctg cgctccaagc ggtacgacat cgcgatgtcg gcgatgacgg
     1501 acaccaagga ccgccaggag ggcatcgacg ccgacaccgg gaagaaggtc ggcgagggcg
     1561 tcgacttcat cgactacttc accgcgggtg tctcgatcta caccaagcag ggcgacgacc
     1621 agggcatcaa gacctgggag gacctgtgcg gcaagaaggt cgtggtgcag cgcaacaccg
     1681 tctccaacga cctggccaag gcccaggcca aggagtgtcc gtcgggcaag aagctctcca
     1741 tcgaggcgtt cgacaacgac cagcaggccc agacccggct gcgcgccggc ggcgccgacg
     1801 ccggttcctc ggacttcccg gtcgcggcgt acgcggcgaa gacctccggt ggcggcaagg
     1861 acttcgaggt cgtcggggag caggtcgagg ccgccccgta cggcatcgcg gtcgccaagt
     1921 cgaacaccga gctgagcaag gccctgcagg ccgcgctcga cgcgatcatc aagagcggcg
     1981 agtacgacaa gatcatcgcg aagtggggcg tcgaggccgg cgccgtgaag gaagccaccc
     2041 tcaacggcgg caagtgaccg cggagccggc ggcgctgaaa ggcaacatcc gtgactgttg
     2101 acatcgacaa aacggccggg ccggagagca cgcccccggg cggaccggag gccatcaagg
     2161 ccatcccggt ccgccactac gggcggtacg tctcggccgt catcgcgatc gcgatcttcg
     2221 tggcgatcgt ctacgcgttc gcccagggca agatcaactg gggtgccgta cccgactact
     2281 tcttcgacga ccggatcctc aagggcgtcg gccagacgat gctcctgacc gtcctgtcga
     2341 tgctgatcgg catcgcgggc ggcatcctcc tcgcggtgat gcgcctgtcg aagaacccgg
     2401 tgacctcgtc gatcgcgtgg ttctacatct ggttcttccg gggcaccccg gtcctggtcc
     2461 agctcgtcgt ctggttcaac ctgggcctgg tcttcgagta catcaacctc ggtcctgtct
     2521 acaaggacga gtggtcgagc ttcatgacgc cgctgctgac ggcgctcctg gggctcggtc
     2581 tgaacgaggc cgcgtacatg gcggagatct gccgcgcggg tctgctctcg gtcgacgagg
     2641 gccagaccga ggcctcgcac gccctgggca tgagccacgg caagaccctg tggcggatcg
     2701 tgatccccca ggcgatgcgc gtgatcgtgc cccccacggg caacgaggtc atcaacatgc
     2761 tgaagacgac ctcgctggtg tcggtggtcc agttcgccga actgttccgg tacgcccagg
     2821 acatcggcca gtcatcgggc gcaccggtgg agatgtactt cctcgccgcc gcctggtatc
     2881 tggttctgac ctcggtgctc agcgtcgggc agtactacgt cgagcggtac tacgcccgcg
     2941 gttccagccg cgctctcccg gccactccgt tccagaagat cagggcgaac gtgctgtcac
     3001 tgtccaaccg ctcgggccga ggagcgaacg catgacctcc aacgtgacca aggcggacgc
     3061 cgtgccgggc tccggtacgc cgatggtgaa ggccgagggc gtccacaagt ccttcggccc
     3121 ggtcgaggtc ctcaagggca tcgacctcga agtgcggccc agcgaggtct tctgcctcat
     3181 cggcccgtcc ggctccggaa agtcgacctt cctgcggtgc atcaaccacc tggagaaggt
     3241 caacgccggg cggctgtacg tggacgggga gctggtcggc taccgccaga agggcgacaa
     3301 gctgtacgag ctcagggaca gcgaggtcgc gctgaagcgg cgggacatcg gcatggtgtt
     3361 ccagcgcttc aacctgttcc cgcacatgac ggcgctcgac aacgtcatgg aggcaccggt
     3421 ccaggtcaag ggtgtcagca gggccgaggc gcgcgagcgc gcggcgcagc tcctgcagcg
     3481 ggtcggcctc gccgacaagg cgggcagcta tccgtcgcag ctctccggcg gccagcagca
     3541 gcgggtcgcc atcgccaggg cgctcgcgat ggaaccgaag ctgatgctgt tcgacgagcc
     3601 gacctcggct ctcgacccgg agctcgtcgg cgatgtcctc gacgtcatgc gcgacctcgc
     3661 cgagtccggt atgacgatgg tcgtcgtcac ccatgagatg ggtttcgccc gggaggtcgg
     3721 cgactcgctg gtcttcatgg acgagggcgt ggtggtcgag tccggacatc cgcgcgacgt
     3781 cctgacgaac ccgcagcacg agcggacgca gtcgttcttg tcgaaggtgc tttagccgtc
     3841 cggcggttcg gccgggtggc gaaggggcgg tacgggtggt ccgtaccgcc ccttcgcgtc
     3901 tggccggcgc cgggtggttc gtcgtgtgcg ggtgggtggg ggctggtcgc gcagttcccc
     3961 gcgcccctga aaggcggggc tgcgcccctg cctttcagct cgcccggcat cctgcttcgc
     4021 gcgcccgtcc ggcgtttgtt tttcagcccg tccggcgttt gaggacgagc gcgttcagcg
     4081 cgatgcgggg gtctgggggc gcagccccca gaagcgacgg gaagggtaag ggcggcgggg
     4141 ggcgaggacc gtggctactt gagcgccagg accagcgcat ccgacggcga gcgccacacc
     4201 ccacgagcct ccgcgaaccc cgccccccga agagcccggg cgtgccactc ggcagaggga
     4261 gtgtccccgt cggcatgctc cccgtagatc tcgaagcggc gcgcggtggg ttcggcgagg
     4321 acaggatcct gcgcggcgag ctgccaccac tcggcccagt cgaggacacc ggccgccttg
     4381 gccccgtcca tgagcgcgtg ccgccgcgcg cgatccgccg cgttgatccg cggggtcgtc
     4441 tcgtcgatca tgtggtccgc gttcatgaac accccgccgt cgcggacgag tccggcgacc
     4501 tgcccgtaga ggaccgtgag aggctcgctg tgcagccagt ggagggcggt cgccgtgagc
     4561 acggcgtcgt acgagtcgta cggcagccgg gacggccagt cggggtcctt gaggtccgcc
     4621 gtgacgaacg tgacccggtc gtcgcccgcg aacgtgccct cggcgatggc caggagcgcc
     4681 gggtcgaggt cgacgccggt actgaccgcc ttcgggaacc tttcgaagag ccgggccgtg
     4741 atacttcccg taccgcacgc gaggtccagg acacgtggtt cggggcccac cagcgcctcg
     4801 accatgtcga gcatgacccg gaagcgctcc tcacggtccg gcatgtacca ctcctgctgc
     4861 cggtcccagc tctcctgcca cgcgtgccag tcggatccga gggtggtcgt catgtaagcc
     4921 cctttccgct tcagatgtaa taccctgaag gcagcattag ccattacagt gtccgcacca
     4981 cgaccttaga gcgcctccgt aaggactaca agtggaactg gcctattact cggattacgc
     5041 cgtccgtctc gtcaacagcg aggagccggc ccggggcacg gacacgctca cctcggtcga
     5101 cgccatccgt gatctcttcg ggggcaacgc gtcggcggcc cgccgcgcca cggactcaga
     5161 cgtgacccgc ttccgcggtg tacgggcccg gctgcgcgcg gtcttcgagg cggcggacac
     5221 cgacgacgag acgctcgccg tggacctgct gaactcactg ctgctggagt tcccggtcag
     5281 cccgcagatc tcgggccacg acatccggga cgacaacggc cgcccgctgt ggcacatgca
     5341 cctggcggat cacccgtcga acgcgaccgc gggatacgcg gcgatcgccg cgatggggct
     5401 ggccttccac ctcaccgagt acggcgtgga ccgcctgggc ctgtgcgagg ccgcaccgtg
     5461 ccgcaacgcc tacctcgaca cgtcgacgaa ccgttcccgg cgctactgct cggaccgctg
     5521 cgccacccgg gcgaacgtcg ccgcctaccg tgcgcgaaaa cgcctggagg cggaccggcc
     5581 ggagagcacc ggccgggcgg ccgacagcag ccagcgcgcg agcgcgaacg gcgagcgctg
     5641 acccttcttc cgcgggcggt accggaaccg caccttcccg aggacgagtt cctcgggcac
     5701 ggttccgtag tcggtactgt caccgccggc gtacgtgttg tcgcccagca cccaccagcc
     5761 tccctcgcgc cgctcggccg cgcgcttcac gaccagcagg tcctgctgga acggatggcg
     5821 caggacgacg acgtcaccgg gcctgaccct ggccccgtac tgcacgacga ggagatcccc
     5881 gtgatgcagc gtgggcacca tggacggccc cgtcacctcg gcggtcccga agggcaggac
     5941 agcccttccg cgctcggtct cctgcgacag ctccggcatc cccggcacct ccccggtcct
     6001 atcctccacg agtcccagtc tgaccccgga cttttgtcct aagcccatgg gggcactcgc
     6061 gaaaacccgt cactcacgga gtaatgtccc acctgagaag acgatcacga ggaaggacag
     6121 ctcaatgctt tcccgcctgt ttgcccccaa ggtcaaggtc agcgcacact gcgacctgcc
     6181 ctgcggtgtg tacgaccccg cccaggcccg tatcgaggcg gagtcggtga aggccgtcca
     6241 ggagaagatg ggcgccaacg acgacgcgca cttccaggcc cgcgccaccg tcatcaagga
     6301 gcagcgcgcc gagctcgcga agcaccacgt ctcggtgctg tggagcgact acttcaagcc
     6361 cccgcacttc gagaagtacc cggagctgca ccagctggtc aacgacaccc tcaaggccct
     6421 ctcggccgcg aaggcctcga ccgacccggc gacgggccag aaggcgctgg actacatcgc
     6481 ccagatcgac aagattttct gggagacgaa gaaggcctga cctggtgtca tgctttctga
     6541 cctgcggtcg catcgcccgg accgcagctc tcctgaccgc acccggtccg cgggccgccg
     6601 aacacggcgt ccggagcggt ccgggtgcgg tcgtcttccg taccaggggc tgaggccgcc
     6661 gagagggccg aggaacgctc aagggcccct gtcagtgggg cgtggaatgc tgagggcatg
     6721 acgacggagg acttggtccg gctgcgcaag gcacgtgacc ggatggaccg tgagtacgcc
     6781 gagccgctgg acgtgtccat gctcgcgcgc accgcgctga tgtcgcccgg ccacttccag
     6841 cgcagcttcc gggcggcctt cggggagacg ccgtacggct atctgatgac gcgccgcatc
     6901 gagcgcgcga aggcgctgct ccggcgcggc gacctgagcg tcacggaggt ctgcctcgcg
     6961 gtggggtgta cgtcgctcgg ttcgttcagc tcccgcttca cggagctggt cggtcggact
     7021 ccgagcgcgt accgggcgga gtcgcacgaa ccgggagcgg caatccctgc gtgcgtggcg
     7081 aagatgtaca cgcgaccggt gcgccgcgcc gcggcgaagc ctctagcgtg aagccatgga
     7141 cctgaaaatc tcgcagtgct tcatctcggt cgacgaccac gatcgtgcgc tggccttcta
     7201 ccgtgacgtg ctgggccttg aggtccgtaa cgacgtcggt ttcgagggca tgcgctgggt
     7261 caccgtcggt cccccgctcc agccggacgt ggagatcgtc ctggaaccgc ccctggccga
     7321 tccgaacgcc ccggaggagg accggcgggc cgtggccgag ctgctggcca aggggctgct
     7381 ccggggcgtc atcttcacca cggagaactg cgacgcgacg tacgaacgac tgctcgccgc
     7441 ggatgccgac atcctccagg agccgatgga ccagccgtac ggagtccgcg actgcgcggt
     7501 ccgcgacccc gcgggcaacc tgctgcgctt cacccagcgc aaggggtgag agcccacgcc
     7561 acgctacggc cgcaggcggg cggctcgggt cctgaggtaa tgctgttcgg ggaggctgag
     7621 ggtcttgtcg gccgccgact cgtaggcggc gcgggcggct tcggtgtcac cggcgcgttc
     7681 caggaggtgg gcgcggaccg cgtcgagacg gtgacccgtc gccaactcgg cttccagtgg
     7741 cgccagtgcg gcgaggcccg cctgcggtcc gtggaccatc gcgacggcca ccgcgcggtt
     7801 gagccgttcg acggggccgg gcacgagccc gacgaggatg tcgtagaggc cgaggatctc
     7861 ctgccagtcg gtgtcgtcgg gcgaggcggc ctcgtcatgg acggcggcga tcgcggccct
     7921 caactggtag gggccggggc cctggtaggg acccggccct cgttgggtca gggcgcctgt
     7981 caccagcgcc acgccctcct cgatcgccgc cttgtcccac agcgtccggt cctgttcgcc
     8041 gagcggcacc aactcgccgt gcgggccggt gcgcgcggcc cggcgggcat cggtgagcag
     8101 catcagcgcg agcaggccgg tgacctcgtg ggaaccgggc agcagttgat gcgtcgtacg
     8161 ggtcaaccgg atggcctcgc ccgcgagttc ggcccgttgg agcgccgtcc ctgaggtggc
     8221 cgtgtacccc tcgttgaaga tcaggtacag gacgtgcagg accgtcggca gccgctcctc
     8281 ccagttctcg gggcgcccga agctcgcgcc cttcaccttc tgcttggccc ggctgatccg
     8341 ctgcgccatc gtcgcctcgg gcatcagatg cgcgcgggcg atctcggcgg tcgtcagacc
     8401 gcccaccgcg cgcagcgtga gggcgatccg cgcgggcggg gtgaggtcgg ggtggcagca
     8461 caggaagagc agagtgagcg tgtcgtcctc ggacggggcg cgggcggccc ccggcggcgg
     8521 cgccgtgaac gcgtcgcgcg gagtgagcgc cgccgcccgt tcctcccgca gtcgccgggc
     8581 ctcctcgctg cgcagcacgt ccgtgagccg ccgcgaggcg accttgatca gccaaccgcg
     8641 cgggttctcc ggcaccccgc tctcgggcca ctgtccggcc gccgcgagca gcgcctcctg
     8701 tacggcgtcc tcggcggagt cgaagtgtcc gtaccgccgc acgagcgcgc cgaggacctg
     8761 cggcgcgtgt tggcgcagca ggccctcgat ctcggtcgtg cgtcccgacg ggcgtctcgg
     8821 gggaccgctc acacgtcgcc gccgccgtcg aagagcggcc ggatgacgac cgggtaccgc
     8881 tgcgtgccct cggggacggg gctttcgagg atccgcccga cgatctccgt gacccgctcc
     8941 aggctgacgc agtcgaggac ccagtagccg gcgagcactt ccttggtctc gctgtacggc
     9001 ccgtcggtga tcacgggctt tccgtccggg ccgggctcga cgaaccgggc ctgggccggc
     9061 ggcgtcagac cgttgccgtc gaccatctca ccggtctcgg cgaggtcgtt gttgatcgcg
     9121 ctcatgtgcg cgaacatcgc ctgcatgtcc tgctcggtcc aggcgggcgc accggcggag
     9181 cccttgccgg cctgcgcctc gtagtccgcc tgggtgccct ggatcatcac gaggtacttc
     9241 atgggtccgc tccttcggtc ggggccgccc gtggtgggcg gttctcacag ggaacgtcgg
     9301 agcggatccg cggttctcta cacacacgcg aaaaaacttt tcgccgacct tctcggacct
     9361 tcgcggcgcc gcgaaggaca acctcctcgc aggcggaagc ggctgtccgg aaccccaggt
     9421 cccgggttca ggaatcccgt tccatggttg cccggggttc cctgggctgc cccggctcgg
     9481 ccatgggcac gggtcctgct tcggaagccg ccgaggccgg cttcacctcg ggcctcccgg
     9541 attcctcacc ttcttcgtaa ctggcacacc gggggttacg gcaggggccg gagccccaca
     9601 cgggcacgaa gacacccagg gtcttgtgcc gacgcacgac catgtcgacg ggctgcttgc
     9661 agaccggaca gacggattca tcgctggcca tggatccagg atattgcgga cggagccggg
     9721 ccgacagccg agcggcagcc ccggaaccgg ggatcgcccg tgcgggggtc cgtgtacagg
     9781 ggtggcgggt cccgcacacc gtggggatgc gcggggcccg ccgtaaccgg agaccctcca
     9841 cctcgccgcg ccgtcaggtg ccgcacgacc tggagaaccc cggcgcctcg gaaacggcca
     9901 caagagccgc accgttcaga tggccccact ggagccccgc tggagccccg ctggagcccc
     9961 gctggagcac cagtggaaca gcgcaccgat ctcctccccg tcaggtgttc cggcgtgtca
    10021 cgaactccgc cagcgacagc agacctcccg cctcctccgg gtccgggacg gcacgggaca
    10081 ggtggtccag ggcccgtgcc atccgctcgg cggcctgggc ctgggcccag tcgcgcccac
    10141 ccgcccgctc gacagcgagg atcgtgcgcc ccagatcgcc gtcccggtag ggaacccggt
    10201 acagctcggc gagttcggcc ccggccggtg tgccggaggc gagcgcggcg accacgggca
    10261 gggacttctt gcgggccatg aggtccgccc cggccggctt gccggtacgc ctcggatctc
    10321 cccagatgcc gatcacgtcg tcgatgaact ggaaggcgag cccagcctcg cgcccgaacg
    10381 cgtcgagtgc ctcgacatcc gcgtcgtcgg cgcccgcgta cagcgcaccg agcgcgcacg
    10441 cgcaccccag cagcgcgccc gtcttggcct cggccatggc aagcacctcg tcgagcgtga
    10501 tgtcgtcggg acagcgacgc tccatcgcgg tgtccgcgtg ctgtcccgcg cacagctcga
    10561 cgacacagct cgcgagccgg gcggccgccg ccgaggacgc cgggtgcgga tcctcggcga
    10621 gcagccgatg ggccagtgcc tgcaaggagt cccccgcgag gacggcgtcg gcgtcgccga
    10681 acacggccca tgcggtgggc cggtgcctgc gggtggtgtc ccggtccatc acgtcgtcgt
    10741 gcagcagcgt gaagttgtgc accaactcca ccgcggcggc cgcccgtacg gccgtcgccc
    10801 ggtggccgcc gagcgccccg gccgcggcca gtacgagcgc gggccggatg gctttccccg
    10861 ccttctccgc gttcgccgcg gccggggtgc cgtccgcgtg ctgccatccg aagtggtaga
    10921 gcgcgatccg ccgcatcgaa ccgggcagcg actcgacggc ccggcgcagt tcgggatcca
    10981 ccgatgtccg ggcccgctcc aggatcacgg ccgcctcctg cccgtcgggc ggaccgtgcc
    11041 gcccgacggg taccgacccg tggtgcggtc ctggcccttc caccgccggt aacaggttct
    11101 gtcgcgtctc cgtcatgaac tcacccatgc ccatgggccc gcctcgaagg acacgcggac
    11161 ggtggcggct ccgccgacgt caggcgcgta accctgtggt ccacccgccc cggcgggcgg
    11221 gaacacgaca ctcggcacat cggagctcac cgccagcggc cgatctcgac gttctccagg
    11281 acgccgagcg catcgggcac caggaccgcg gccgagtagt acgtcgtcac caggtacgac
    11341 atgatcgcct gctcgctgat gcccatgaac cgcacggaca ggctcggctc gatctcgtcg
    11401 ggaattcctg cctgctggag accgacaacc ccttgctcgg cctctcccgt acgcatggcg
    11461 atgatcgagg tcgtcctggc ctcggtgacc gggatcttgt tgcacgggaa catcggcacg
    11521 ccccgccagg tgggaatgcg gtggcccgcc acgtcgaggg tctcggggac gagcccgcgc
    11581 ctgttgagct cgcggccgaa cgcggagatc gcccgagggt gagcgagcag cagcttggtg
    11641 ccgcgccgcc tggtgagcag ttcgtccagg tcgtccgggc tgggtacgcc gtcgtgcggc
    11701 tggagccgct ggtcgtactc gcagttgttg agcagcccga actcgcggtt gttgacgagc
    11761 tcgtgctcct ggcgctcctt cagtgcctcc acggtgagcc gcagctgctg ctcggtctgg
    11821 ttcatcggct ggttgtagag gtcggccacg cgcgtgtgga tgcgcagcac ggtctgggcg
    11881 acgctgagtt cgtactcccg tggcgcggcg tcgtagtcca cgtacgtccc ggggatggcc
    11941 ggctctccgg tgtggccggc cgcgaggtcg atctccttct ctccgtacgg gttggaacgc
    12001 tgctcgggaa tcgtgcgcaa ccgctcaagg tgctcacgca gggactcgga gcgctccgcg
    12061 atctggtcga ggtccgcgcg gggcagggtg aggaccgtgc acgcggtggc cgcgcgggcc
    12121 gtgtactccc agatggcgtc cgggtcggtg atcgcctggt cgccgaagta ggagccgtcg
    12181 gcgaggactc cgaggacggc gtcgtccccg tacggtccgg tgccgacctt ctcgaccctg
    12241 ccgtgcgcca gcaggaacac ctcctcggcc gggctgccga aggaggcgag tacgtcgccc
    12301 ggcccgaact cccgctgctc gcagcgctgg gccagctcgc tgagtacctc ctggtcctcg
    12361 taggtgcgca gcgccggcag ttcgccgagc tccgccggga tgacctggac gcggtcaccg
    12421 gtcttcacga acgtgacgcg gccgtctccc accgagtagc tgagcctgcg gttcacgcgg
    12481 tacgtgccgc cctgcacatt cacccacggc agcatgcgca gcagccatcg tgagctgatt
    12541 tcctgcatct gcggtacgga cttggtggtc gtggccaggt tccgcgccgc ggatgtgccg
    12601 agactcttct gcggctggtc ctggtccgcg cggatctctt cgcctaccga catgaaaatg
    12661 tcctccccat cgtgcaatga gctgcggcga ccacacttcc atcacggacc gtggtcgtgc
    12721 tattacccga aagaggggga atgggtcttc gcgaaacggg gcacatcgcg cgcccccgac
    12781 cacttcggcc ggccgctccc gagggttcgt ggatctttcc gaccgggaac ttcaagatcg
    12841 ggccgcccgt tcattcagca gtaccgccga cgacggagga gagagcacat ggcaggcttt
    12901 ctggaccgcg ccaaagagca ggcgcagcgc ggcatcacgc agggcaagca gaagatcgac
    12961 gatgtgcagg cgcagcgggc cggcagtgat ctgctgaaga gtctcggcgc ggcctacctc
    13021 gcggagcggc gcggcagcgg atctccgcag gccacgcagc aggcactcca ggccgtggag
    13081 agccacatcg cgacgcacgg ggacagcttc ctgcgctcct aggcgacctg tcggcggctc
    13141 cgtccggacc gctgaccggg tcggctcgca caccgtgcga agaatgcgaa gaagtggtcc
    13201 ctccaggccg gttccgggta caagccgcgg tacgaggcgg ctgcgacagg tggccgtcgt
    13261 cccctgcaag gaggcggccg tgtccccacc catgtccgcg agcagctttc tgagccggct
    13321 caaggcggaa ggaatcaccg tcgtcgaggt cggcgactgg gagcatcaca accgcaatca
    13381 caagggcccg tggggccagg tccacggcgt gatgatccat cacacggtga cgtcgggccg
    13441 ccggcggacg gtcgagatct gccgcgacgg gtacagcggg ttaccgggcc cgttgtgtca
    13501 cggcgtcatc accaaggacg gccgggtcca tctcgtcggc tacggccgcg ccaatcacgc
    13561 gggcctcggc gacgacgacg tgctgcgcgc ggtcatcgcg gagaaggccc tgccggcgga
    13621 caacgaggcg aacaccgacg gcaaccgcca tttctacggc ttcgagtgcg agaacctcgg
    13681 cgacggcaag gatccctggc ccgaggccca gctggaggcc atcgagcggg ccgccgcggc
    13741 ggtctgccgc catcacggct ggacggagcg ctcggtgatc ggccacctcg aatggcagcc
    13801 gggcaagatc gacccgcgcg gtttcacgat ggccgccatg cgggcccgta tccgcgaccg
    13861 cctgaagtga cacgcagctg aagtgattcg cggctgaagt gacacgtccc gcgcatgtcg
    13921 ctcggacggg tgtccgacaa tgggggtgtg accggccccg acacccctga cgcagtcgcc
    13981 ctcggcgtcc tgcggccgcg gctgccgtcg ccgctgcagg aggtcgtgga cgagcgtttc
    14041 gagcggcgcg gtgtgcggct gctgctcaag cgggacgatc tgatccaccc ggagctgatc
    14101 ggcaacaagt ggcgcaagct ggccccgaac ctcctggcgg cgaggggccg cacggtcctc
    14161 accttcggcg gcgcgtactc gaaccatctg cgggccacgg ccgcggccgg ccgtctcctg
    14221 ggcctgccca ccgtcggcgt ggtccgcggc caggagctcg ccgaccgccc cctcaacccg
    14281 tccctcgccc ggtgtgcggc ggacggcatg cggctccatt tcatcgacag atcgacatac
    14341 cgccgcaaga gcgatccggc gacactggcc gccctgcgcc gcgcgaccgc ctgcgaggac
    14401 gcgtacgtga tcccggaggg cggcagcaac gcccttgccg tgcgcggctg tacggccctg
    14461 ggcgaggaac tgcgcggcca cgccgacgtc gtcgcactgg cctgcggcac gggcggcaca
    14521 ctggcgggcc tggccggggg cctgtctccc ggccagcgcg cgctgggcat accggtcctc
    14581 aggggcggct tcctcggcgc ggagatacgc gcgctccagg aggcggcgtt cggcggtccc
    14641 cgcggcgact ggtccctgga cgaccgtttc cacttcggcg gctatgcccg tacacctccc
    14701 gaactggacg cgttagcggc cgacttcggg cggcgccacg acctgcctgt cgaacgtctc
    14761 tatgtcgcca agtcgctgta cggactcctg accctcaccc aggagggcgt tttcccgcgc
    14821 gggacgacgg tcgcggccgt gatcacgggc agcccggacg acactgtcca ggtcggcccc
    14881 aagtcccagg tcggtacatc cgactaggtc gcttccctga acgccgcggc ctcctccagg
    14941 tccagtcgcc gcagcagggt ccgcagcatc tcgtcgtcga tgtagcggcc gttgcgcagt
    15001 ttcacgaaca cggcgcgctc ggcgccgatc atctcccggg acagccggcg gtacgtgtcg
    15061 tccgcggttt ctccggtgac ggtgttgacc tggccgaggc gttcccagac ggcgttgcgg
    15121 cggcgctcca gaaccgcgcg gaggcggacg gcgaggggcg gtggaagcgt gttgcgctcg
    15181 tcggagagga gttcctccag gcgctgctcg gcggcccggg aggcctgcgc ctgggcgttc
    15241 gcctccgcga gggtctcggc ctgctggtcc cgtgccggga gtttcagcag gcggatgagc
    15301 gggggcagcg acagtccctg cacgacgagt gtcccgatga ccgtcgtgaa ggtcaggaag
    15361 aggatcagat cgcggccggc gaagtcctcg ccgccttcca cggtgagcgg gatcgagaag
    15421 gcgatggcga gcgagaccac gcctctcatc ccggcccagc tgatgatgaa gggccccttc
    15481 caggtggggt tggcctcccg ttcccggatc cgcgcggaca gcaggcgggg caggaaggtc
    15541 gcgggataca cccaggcgaa gcgggtcagg acgacgatcc cgaagagggc caccgcgtac
    15601 cagacggcgc tcgccccctc gtacgcgccg aggcccttca ggatcaccgg cagctgcagg
    15661 ccgatgaggg cgaagaccgc cgactccagg atgaacgcga ccatcttcca gaccgcctcc
    15721 tcctggagcc gggtcgcgaa gtcgacctcc cagttgcggt gccccaggta gagcgcgacg
    15781 acgaccacgg cgagcactcc ggaggcatgc acctgctcgg cgaccgcgta cgcgaagaag
    15841 ggcgtcagca gcgacaggga gttctgcagc agcgcctcgt tcagacgggt gcgcatccag
    15901 tggatcggca ccatcaggac gagcccgacg ccgatgccgc ccagcgccgc gagcaggaac
    15961 tcgccgatgc cgcccgccca ggtcgcgccc tctccgacgg ctgcggcgag cgccaccttg
    16021 taggcggtga tcgcggtcgc gtcgttcacc agcgactcgc cctgcaggat cgtggtgacc
    16081 cgcgacggca gcccgacccg gcgcgccacc gccgtggccg ccaccgcgtc cggcggtgcc
    16141 acgaccgcgc cgagcaccag cgccgcggtg agcgacaggt ccggcacgag cacgtacgcg
    16201 gcccagccga cggcgagcgt cgcgaacagc acgtacccga ccgacaggag cgccaccggc
    16261 cggagctgcg cccgcagatc gaggtacgag ctgtccgtgg cggccgtgta gagcagcgga
    16321 ggcagcagca gcggcaggac gatgtgcggg tcaagggtgt actcgggcac cccgggcacg
    16381 tacgagacga caagccccgc cgcgacgagg agcaggggcg cgggcaccgg agtacggcgc
    16441 gcggcgcccg ccaccgcggc gctgcccgcg atcagcagga gcaggggcat cacatgcatc
    16501 ggtataggcc cgctttcgtt tccgcgcgga ttcccgcaca cccgacgtaa tctggcaatc
    16561 atgaaacagt gcacgcacgc cgacgcgctg ccgcccacgg aacccgcgcc gctgagcgac
    16621 acctgtctcg aatgccaggc ggcggggtcg cacccggtgc agctgcggct gtgtctggac
    16681 tgcggtcacg tgggctgctg cgactcgtcg cagctgcggc acgccacaga gcatttcaag
    16741 gagacggggc atccgatcat gcggaccttc gagcccggtg agagctggcg ctggtgcttc
    16801 gtcgaccatg tgctggtgtg acgtgggttc cggacggttc gaccgtctga cgtctgggta
    16861 cgtcaatccg gcgcgcgctc ttcccaattg ggcccgcaga cccctagcca ctgtacgtgt
    16921 ccataggttt actatgagtg acagcaaggg gttggggtcc cggggacagg aaacctgaga
    16981 gcgcgatagc gtcaccgctg aaccacgtag cgcgttaccc cggggggcga ccctcggccc
    17041 ccgaaagagc ttgtaccacc ttggaggtga gggtgtccca gatcgcaggc gagcccgcga
    17101 cccaggactt cgtggaagtc cggctgccgg ctgcgggtgc ctacctgtcg gtgctgcgta
    17161 cggccacggc cggcctcgcg gcgcgcttgg acttcaccct cgacgagatc gaggatttgc
    17221 gcatcgccgt ggacgaggcg tgcgcgatcc tgttgcaaca ggcggtgccg ggctccgtgc
    17281 tcagctgtgt cttccgcctg atcgacgact cgctcgaggt gactgtctcg gccccgacca
    17341 ccgatggcca cgcccccgca cgggacacct tcgcgtggac cgtgctgtcg gccctcgcag
    17401 gcaaggtctc ctcctcggtg gccgacgaca aaaccgtttc gatcagcctc tacaaacagc
    17461 gcggcgcggg acccgggccg gcgtgaggaa cggggacggg ccggtgcggg acgaagagcg
    17521 cggcacacgg gaactccccg ccgggggcga gaacggcccc ggcgggcccc ggcacctggc
    17581 ggagggcgtc gacggcattc ccgagcagca ggcccggccg cacccggagg acgacagttc
    17641 cccggcggcc ggggtgtctc ggggagagcc gatcggcaag gacgagcgcg aggcgctttc
    17701 cggcagcgac gggcgacagg atccagacgt tgccgcgcag tgggggtccc cccggacgga
    17761 gtctgggggg acgtccttgg aagggcggcg gcgggtgacg ggcgggatca tgagcgagca
    17821 gcacgagcac gaacgaaatg ccgagaacgg cgcgtcgggt acgcagcacg atccccacaa
    17881 caggagcggg gcgcggctca agttcatcga gctgcgcaag ctggaccacg acagcccgga
    17941 gtacgcggaa ctgcgcaacc agctggtccg tatgcacctg ccgctcgtgg agcacctcgc
    18001 ccgccgtttc cgcaaccgcg gcgagccgct ggacgacctc actcaggtcg cgaccatcgg
    18061 cctgatcaag tcggtcgacc gcttcgaccc ggagcgcgga gtcgagttct cgacgtacgc
    18121 gaccccgacg gtcgtcggcg agatcaagcg gcacttccgg gacaagggct gggccgtgcg
    18181 cgtaccgcgc aggctgcagg agctgcggct cgcgctgacc acggcgaccg cggagctctc
    18241 gcagcagcac ggccgctccc ccaccgtgca cgagctggcc gagaagctgg gcatctcgga
    18301 ggaggaggtc ctggagggcc tggagtcggc caacgcgtac tccacgctgt ccctggacgt
    18361 ccccgacacg gacgacgagt cgccggccgt cgccgacacc ctgggctcgg aggacgaggc
    18421 cctggagggc gtcgagtacc gggagtccct caagccgctc ctggaggacc ttcccccgcg
    18481 cgagaagcgc atcctgctgc tgcgcttctt cgcgaacatg acccagtccc agatcgccca
    18541 ggaggtcggc atctcacaga tgcacgtctc ccggctgctg gcccggacgc tggcccagct
    18601 ccgcgagaag ttgctggtgg aggagtgagg agtgagcggc acagctcgcg tcccgtaaag
    18661 gctcgcgtcc cgtaaaggct cgcgtcccgt aagcagctcg tgtcccgtga acagcccgtg
    18721 tcccgtgtcc cgtaaaacag ctcgcgtccc gtgaggggcg cggcgcaccg cacgacccgg
    18781 tccgcgctac tcgggctccc gcactccgcc cggcccggtg atccccagcg ctctcgtggt
    18841 ctcggggttg aggatcagca ccagtgtcac gaccgccacc accgccaggg cgatcccccc
    18901 agggatggcg agactgtcgg cctggagcag gttgtacgcg acgggcagcg ccatgatctg
    18961 cgtgatgatc gtggggcccc ggctccagct gcgccgcagc agcagccccc gcgcggccag
    19021 cagtggcagc agggcgagca cgatcagcgt cacgcccccg gtgaccgcct gacggcggtc
    19081 gtcgggatgg ccggtgaagc ccatcacgag caggtagacg cccccggcgg caagggcgag
    19141 cccctccagc gcggcgagcg cggccgccac ggtcagccgc ccggggcggg gttcggcgtc
    19201 gacggtttcc ggggtgggat tctgctcaga gctcacctgt gaagggtagc cctcgacccc
    19261 tgtccggcca cggccccggg gcgtttcgcc gggcattcga caggtcccgc cgctctcacc
    19321 tgatcctcac ctcggtatgg gacgagtacc gcgcggtagg tacgctgcat cgcatgcgtg
    19381 cacttcttgt ggtcaatccg gcagcaacca ccaccagcgc acgcacgcgt gacgtcttga
    19441 tccacgccct ggcgagcgag atgaagctcg aagcggtcac caccgagtac cgcggccatg
    19501 ccagggatct cggccggcag gccgcggaga gcaaggacat agagctggtc gtggccctcg
    19561 gcggcgacgg cacggtcaac gaggtcgtga acggtctgct gcacaacggc cccgaccccg
    19621 accggctgcc cggcctcgcc gtcgtccccg gcggctccac caacgtcttc gcccgcgccc
    19681 tgggcctgcc caacgacgcc gtcgaggcga ccggcgccct cctggacgcc ttgcgcgagg
    19741 gccgggagcg cacggtgggt ctcggtctcg ccgcgggcac cccgggcagc gacgacgagg
    19801 gtgtccccgc ccgctggttc acgttcaacg cgggcctcgg cttcgacgcc ggcgtggtcg
    19861 gccgcgtcga acagcaccgc gaacgcggca aacgctccac gcactctctc tacgtgcgcc
    19921 aggcgatgcg ccagttcttc ggggagaccc accggcgccg cggcaccatc acgctggagc
    19981 ggccgggctc cgacccggtg accgatctgg tgctgtcgat agtgtgcaac acctctccgt
    20041 ggacgtatct gggcaatcgc ccggtgtacg cgtcacctaa ggcctcgttc gataccggcc
    20101 tcgacgtact cggtctcagc cgcatgtcga cggccgcggt tgcccggtat ggcacccagt
    20161 tgctcacttc gtcccccgag cgcggccccc atggcaagca cgcggtgtcc ctgcacgatc
    20221 tgaccgactt caccttgcat tcgaaggtcc cgctgcccct gcagatggac ggtgaccacc
    20281 tcggactgcg tacgagcgtc gcgttcacag gcgttcgtcg tgcactgcgt gtgattgtgt
    20341 gagcggaacg ggccaaagtc cttccactcg aacgtttagg ccaggatcca ccccatggaa
    20401 gtacggctgt gacctagtcg acaccgagga atcaaaaaaa actttccgga aggggttgta
    20461 tccgccgccg aggtttgcga gtctctacgt ggcgctcggg tcgggccgca acatcgcccc
    20521 cacagagcgc cggaacccct cctcacatcc aggaccacgc cagtccgtct ggtagtcggc
    20581 ccttcacttg ttgagggatt cgtgaaagcg ttcacattca caagcaacgt gcatgtaata
    20641 ccaaggagag gtagcagcca tggactggcg tcataacgcc gtttgccgcg aggaagaccc
    20701 cgagctcttc ttccccatcg gcaacaccgg tcctgcgctg ctgcagatcg aggaagccaa
    20761 ggccgtttgc cgtcgctgcc ccgtcatgga gcagtgtctg cagtgggcgc tcgagtccgg
    20821 ccaggactcc ggcgtctggg gtggtctcag cgaggacgag cgccgcgcaa tgaagcgccg
    20881 cgccgcccgc aacagggccc gtcaggcctc cgcctgacaa cccgccccac gacagcctgg
    20941 cttggcggcg cgtacagcga gtacgcatct cccgcccccg agccgcagcg cgcagtaccc
    21001 ccgatgcgca caaccgaatg acactgtgag ccccggacca ctcagtggtc cggggctcat
    21061 tgctgtttgc gatcgtggac tcgtcggctg ttcgagcgac cctggcgccg ccgaaccaac
    21121 ccacgagg
//
