LOCUS       NZ_AP023440            23550 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces aurantiacus strain JCM 4677 chromosome.
ACCESSION   NZ_AP023440
VERSION     NZ_AP023440.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces aurantiacus
  ORGANISM  Streptomyces aurantiacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 9428393)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014701115.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 05:58:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,211
            CDSs (total)                      :: 8,122
            Genes (coding)                    :: 7,928
            CDSs (with protein)               :: 7,928
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 161 of 194
            Pseudo Genes (internal stop)      :: 17 of 194
            Pseudo Genes (multiple problems)  :: 48 of 194
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:48:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2456722
            Orig. end                         :: 2480272
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023440.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017557
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23550
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="blactam"
                     /region_number="16"
                     /rules="(BLS or CAS or tabtoxin)"
                     /tool="antismash"
     cand_cluster    1..23550
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(BLS or CAS or tabtoxin)"
                     /kind="single"
                     /product="blactam"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23550
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:13550](+)"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13550
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
     misc_feature    complement(12..25)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.15"
                     /tool="antismash"
     gene            complement(226..606)
                     /locus_tag="IGS71_RS09940"
                     /old_locus_tag="GCM10017557_20500"
     CDS             complement(226..606)
                     /GO_function="GO:0019239 - deaminase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953012.1"
                     /locus_tag="IGS71_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20500"
                     /product="Rid family detoxifying hydrolase"
                     /protein_id="WP_190850014.1"
                     /transl_table=11
                     /translation="MKTQVFTTENAPTPVGPYSQAVRRGNIVSVSGQVGLDPANNKLVE
                     GGIAEQTRQTLTNLENILKNSGASFADVVTVRIYITQAADFAPMNEVYAKFLSEPFPCR
                     TTVFVGLPPGMLVEIDVLAVVD"
     gene            802..1815
                     /locus_tag="IGS71_RS09945"
                     /old_locus_tag="GCM10017557_20510"
     CDS             802..1815
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012512.4"
                     /locus_tag="IGS71_RS09945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20510"
                     /product="threonine/serine dehydratase"
                     /protein_id="WP_190850015.1"
                     /sec_met_domain="PALP (E-value: 1.9e-71, bitscore: 239.8,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTDATPVDIDTGNRATPSPLLTEQDLKSAAARLTGRVLKTPLLP
                     CEELSLAFGCQVLLKAENLQHTGSFKVRGATNALLARGERGERPSHAVTFSAGNHGAAL
                     AYASRRLGVPATVFVPPGAVATKIDAIRRHGATVIEGEDFVAAAQRFAERNGALLLHPF
                     DDLDVIGGQGTVGLEVWQALPWVDVLLAPVGGGGLLSGIGAAFAALSPSTRVVGVEPAA
                     ARALAHAVESGGPVSLPTAPTSMADGLNAPFAGTHTYHHVLHHTHQLVQVSEEEIRLAW
                     IDLMRATRLILEPSAAVGLAALRTGEVAVPAGGVVVLVLSGGNTDLASLGAASRAV"
     gene            complement(1916..2416)
                     /locus_tag="IGS71_RS09950"
                     /old_locus_tag="GCM10017557_20520"
     CDS             complement(1916..2416)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009996861.1"
                     /locus_tag="IGS71_RS09950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20520"
                     /product="flavin reductase family protein"
                     /protein_id="WP_198427923.1"
                     /transl_table=11
                     /translation="MIPGTLDATLFRSVLGHYPTGVALVTSAGEPPAGMIVGTFTSVSL
                     DPPLVGFLPSKASTSWPRIRAGGSFCVNVLGADQREVCLAFTSRDTTRWEVPHHPAPSG
                     APVLSGAIAWIDCDLADETEAGDHWFVTGHVRRFQVQHEGEPLLFLRGEFGAFAPCPAP
                     VLD"
     gene            complement(2413..3612)
                     /locus_tag="IGS71_RS09955"
                     /old_locus_tag="GCM10017557_20530"
     CDS             complement(2413..3612)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090797.1"
                     /locus_tag="IGS71_RS09955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20530"
                     /product="serine hydroxymethyltransferase"
                     /protein_id="WP_055514611.1"
                     /transl_table=11
                     /translation="MDVLATLRRQPSLNLFPIENRLSPRALEALSSDANNRYPYSETDV
                     AVYGDVTGLNDVFTYCTDLTKQFYGARHAYVNFLSGLHTMHTVITAVATAGDRVMVLAP
                     EDGGHYATATICRGYGHEVDFLPFDRGTLEIDYAKLATTVAERPVDLIYLDASSMLRFP
                     DARALRAAAPDALICLDASHLLGLLPVAPQTLVLDGGFDSISGSTHKTMPGPQKGLLVT
                     NSDRMAELVGARIPFTASSSHSASVGSLAITLEELMPHRTAYAQQVIDNARALGSQLAS
                     RGFDVAGKDFGYSETHQVWVHLPDGHTTHQWGRTLTAAGIRSTTVQLPSTGRPGLRLGT
                     QELTRWGMRESDMSVVADLLARLLLRGEAVKEIAEDVSTLALSYPGVAFAGPLAPLASR
                     "
     gene            complement(3641..4108)
                     /locus_tag="IGS71_RS09960"
                     /old_locus_tag="GCM10017557_20540"
     CDS             complement(3641..4108)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961116.1"
                     /locus_tag="IGS71_RS09960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20540"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_190850016.1"
                     /transl_table=11
                     /translation="MPSNQAATDEQRKAVVIAYLKAFDNGGTGTDGRSVLDFFAQDAQF
                     FFPKWGLAKGRPEISRLFDDLGPTIKSITHHFWSFNWLTTGTDLLAAEGTTHGEHHDGP
                     WHVGLPEWGGGRFCGVFEVRDDLIQRAFIYMDPDYAGQDTARYPWLDGTRH"
     gene            complement(4165..5349)
                     /locus_tag="IGS71_RS09965"
                     /old_locus_tag="GCM10017557_20550"
     CDS             complement(4165..5349)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961112.1"
                     /locus_tag="IGS71_RS09965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20550"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_055514607.1"
                     /transl_table=11
                     /translation="MKSILFYLPSTGSHMQITRGMAGTNPANYQNMLRQLTHQVRAADE
                     MGYWGASFTEHHFHIEGFEVSNNPILLGLYLGQQTKNIRIGQMANVLPLHNPIRLAEDL
                     SMLDHMMRGRTFVGIARGFQRRWADVMGQVYGVGGTLSDRSESDRRNRRLFEEHWEIIK
                     KAWTNETFTHEGEQWTIPPKDLEFPYDAVRRFGRGQDDAGRIVEVGIAPRPYQNPHPPV
                     FQPFSFSEDTFRFCARENVVPIVMHTDPVRVGELLDVYVEEAEAAGRGRLARGESVGVM
                     RDVLVSRNKEEAHHWARHGGGFIFDNWFGPMGFTEALRNTGETGPIGSDYDTLVERGLE
                     WVGTPDDINRKIERLVEHHTPEYLLQCQYSGPIPHDVQMRSLELWATEIAPNWL"
     misc_feature    complement(5334..5348)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.04"
                     /tool="antismash"
     misc_feature    5426..5439
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            5545..6915
                     /locus_tag="IGS71_RS09970"
                     /old_locus_tag="GCM10017557_20560"
     CDS             5545..6915
                     /NRPS_PKS="Domain: Aminotran_3 (39-387). E-value: 3.5e-91.
                     Score: 297.6. Matches aSDomain:
                     nrpspksdomains_IGS71_RS09970_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963441.1"
                     /locus_tag="IGS71_RS09970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20560"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_055514604.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-86, bitscore:
                     289.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAATGISRSRHATGELVRLDRERILHPLLPDGREDRTVLVKGEG
                     CRVWDADGREYLDASAVLGVMQVGHGRRELAAAAAEQLGRLDYFHTWGTITNDRAIELA
                     TRLTDLAPPGLDRVFYTSGGSEGNEIALRLARYYHHRKGASGRNWVLSRHTAYHGIGYG
                     SGSLSGSPVYQDGFGPVVPNVHFLTPPHPYQKQWYAGEDPTDFCVRELEAAIEKIGPEH
                     IAAMIGEPVMGGYGAVVPPADYWPRVAEVLRRHGILLIFDEVVTAFGRTGRWYSAEHFG
                     VVPDILVTAKGITSGYIPHGAVLVSEEVSEVVGAEGGFPIGFTYTGHPTACAVALANLD
                     IIEKEGLLANATGTGAYLAAGLRSRLLGLPAVGDVRQIGLMLAVQLVSDQETGADLPGG
                     TLRVADALREQAGILVRNNAHALIVSPPLVLDRGTADKIVDGFRFVLERLGTDGSVR"
     aSDomain        5662..6705
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS09970_Aminotran_3.1"
                     /evalue="3.50E-91"
                     /label="IGS71_RS09970_Aminotran_3.1"
                     /locus_tag="IGS71_RS09970"
                     /protein_end="387"
                     /protein_start="39"
                     /score="297.6"
                     /tool="antismash"
                     /translation="LVKGEGCRVWDADGREYLDASAVLGVMQVGHGRRELAAAAAEQLG
                     RLDYFHTWGTITNDRAIELATRLTDLAPPGLDRVFYTSGGSEGNEIALRLARYYHHRKG
                     ASGRNWVLSRHTAYHGIGYGSGSLSGSPVYQDGFGPVVPNVHFLTPPHPYQKQWYAGED
                     PTDFCVRELEAAIEKIGPEHIAAMIGEPVMGGYGAVVPPADYWPRVAEVLRRHGILLIF
                     DEVVTAFGRTGRWYSAEHFGVVPDILVTAKGITSGYIPHGAVLVSEEVSEVVGAEGGFP
                     IGFTYTGHPTACAVALANLDIIEKEGLLANATGTGAYLAAGLRSRLLGLPAVGDVRQIG
                     LMLAVQLV"
     gene            complement(7074..8069)
                     /locus_tag="IGS71_RS09975"
                     /old_locus_tag="GCM10017557_20570"
     CDS             complement(7074..8069)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657195.1"
                     /locus_tag="IGS71_RS09975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20570"
                     /product="aldo/keto reductase"
                     /protein_id="WP_342671057.1"
                     /transl_table=11
                     /translation="MRSPSMPPLRRLRQLEVSAQGFGCLPTTVFYGSPTRTEATAVLRA
                     ALDAGVTLFDTADVQGLGAGEELLGEVLAGRRDEVLIATKFGMRRGGDGSFLGLCGRPE
                     YVREACDASLRRLGTDRIDLYYQHWIDPEVPVEETAGAVAELVRAGKVRSFGLSEPSAD
                     SVRRADAVFPVTAVQSEWSLWSRDVEDEVVGVCRERGIGLVAYAPLGRGFLTGAIRHHS
                     QLTADDFRQNLPRFQPANLERNLAIVRRLDTLARRLGVSAACLALAWLHHQGPDVIPIP
                     GTTSPAHLADNLAATRLALGPSESAALREVAALRVHGERYRPEMLAMTGT"
     gene            8323..9996
                     /locus_tag="IGS71_RS09980"
                     /old_locus_tag="GCM10017557_20580"
     CDS             8323..9996
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953014.1"
                     /locus_tag="IGS71_RS09980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20580"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_055514600.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-41, bitscore:
                     141.0, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.6e-33, bitscore:
                     113.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASKKTAELLLRRLHEYGVDHVFGVVGREAEAILFDEVDGLEFVL
                     TRHEFTAGVMADVLARLTNRPQACFATLGPGMTNLSTGVATSALDRSSVIAMAAQSESH
                     DCFPNVTHQCVDSVAVMAPLTKFSAQLERPADITSLVDTAVLHSTTEPVGPSFLSLPID
                     LLGADVPEDAAQAAPVVGYRKKAVVDPTWTELVPGIADKIAAAKHPVLVVGSAVIRADG
                     VDALRSFAERLRIPVVTTYTAKGVLPHDHPLNYGAISGYMDGILSFSALDQIFGPVDLI
                     VALGYDYAEDLRPSMWTRGTEKEVVRVAATVNPITALFRPTVDVVADPREVIETLDKAT
                     AHLMAKTPHDIEPLRARVAEFLADDEEYSDGMRVHQVIDCMNSVLENGTFVSDIGFFRH
                     YGVLFAKADQPYGFLTSAGCSSFGYGLPAAMAAQIARPDEPVFLIAGDGGFHSNSADLE
                     TAVRLGLPLVMVVVNNDRNGLIELYQNKGHQRSHAPAVAFRSVDFVQLAEANGCDAVRA
                     TDRESLVQALRKGAELGRPFLIEVPVAYDFQSGGFEALDI"
     gene            10001..11545
                     /locus_tag="IGS71_RS09985"
                     /old_locus_tag="GCM10017557_20590"
     CDS             10001..11545
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: BLS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963438.1"
                     /locus_tag="IGS71_RS09985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20590"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_190850017.1"
                     /sec_met_domain="GATase_7 (E-value: 2.2e-13, bitscore:
                     49.1, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="BLS (E-value: 4.3e-149, bitscore: 495.7,
                     seeds: 11, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.3e-27, bitscore:
                     96.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMGPNLVAGFWARVSWSPRRAAPETPRFATQGHTSAVSAASAGRH
                     LQGVAVSFGAPDTLVSDGGIHLLLAGEIYNRDEVAKALGNASAAHGSDATLVLAAWHHW
                     GITAFRILNGRFAALLLDGGGRVVVATDHAGSVPLWLRADAHGVDVSTEAKTLAGLPGT
                     PLDVAGAQLLPGGTGVHRVQAGTALILETVQGEVRTANRVYTWTPPVSRAAVGEEIAVG
                     RVRRLLAQAVQTRLRDDPEPTVVLSGGIDSSGVAAHAVAHSGLVHSVSMGTEASDEFGP
                     AKVVAGHLGTDHSEMTIHSSDLVRELPWAVWAAEIADHTILEYLLPLIALYRRLPPGPR
                     RVLTGYGADIPLGGMHRHTEPLDLLDSVIAHDMATFDGLNEMSPVISGVAGIWSTHPYW
                     DRDLLDCLISLDPGLKRRYGRDKWVLREALARMLPAETLSRPKLGIHEGSGTSSAWTAL
                     LLEKGVPPGRVEQCKAAMARRMHDLIVLRTRHPDEISFDEVLAATEKGRTRHALEQ"
     gene            11529..>12491
                     /gene="speB"
                     /locus_tag="IGS71_RS09990"
                     /pseudo=""
     CDS             11529..>12491
                     /GO_function="GO:0008783 - agmatinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008295 - spermidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="speB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241266.1"
                     /locus_tag="IGS71_RS09990"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="agmatinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHSNNDGSDFATSGKTQLSSGSSPRYAQLATFMRLQHDPSPVGHD
                     VVVIGAPYDGGTSYRPGARFAPRAIRHESCLIHGTGIDRGPNVFDLIDVVDGGDIDLSP
                     FSQDIAMETATEALTGLLSDNDAFLMLGGDHSLSLAAMRAVHGRHGRLAVLHLDAHSDT
                     NPPVYGGTYHHGTPFRWAIEEGLAAPDHVVQLGIRGHNPRPDSLDYARGHGVRVITAQE
                     FFTRSLDDVVREIRSVVGDLPLYVSVDIDVADPAYAPGTGTPAPGGLSSREVLALLSVV
                     GDLKPVGFDIVEVLPTHDPAGITALLAAEVGAELLYQYAR"
     gene            <12624..13550
                     /gene="cs1"
                     /locus_tag="IGS71_RS09995"
                     /pseudo=""
     CDS             <12624..13550
                     /GO_function="GO:0033758 - clavaminate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0033050 - clavulanic acid biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (45-285). E-value: 1.5e-21. Score:
                     69.3. Matches aSDomain:
                     nrpspksdomains_IGS71_RS09995_TauD.1"
                     /codon_start=1
                     /gene="cs1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: CAS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF043003.1"
                     /locus_tag="IGS71_RS09995"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="clavaminate synthase Cs1"
                     /pseudo=""
                     /sec_met_domain="CAS (E-value: 1.2e-136, bitscore: 454.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="TauD (E-value: 2e-19, bitscore: 69.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LLELRERLPQTPRLDMSDFFATAGALSQELPEHLRAALRDFRATG
                     NEAGYLMLTGLPVSDEELPETPTSTPAPVERPLLSMEAWLTLIGMELGLPTGYRELRAG
                     TILQDVYPSPNAHYLSSETSETLLEFHTEMAYHKHQPHYVMLACSRADHEGTAATLVGS
                     IRKALPRLDRATRAELYRKPMRCHVDMAFRPGKDTDPLYQISVLDGHREDPLLAYDREL
                     LDPVDLPAKRALAELSDALDAVTEPVHLKPGSLFIVDNYRTTHARTPFTPRWDGKDRWL
                     HRMYVRVPERMTDSTAQMGDVVDFVGR"
     aSDomain        12762..13481
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS09995_TauD.1"
                     /evalue="1.50E-21"
                     /label="IGS71_RS09995_TauD.1"
                     /locus_tag="IGS71_RS09995"
                     /protein_end="285"
                     /protein_start="45"
                     /score="69.3"
                     /tool="antismash"
                     /translation="NEAGYLMLTGLPVSDEELPETPTSTPAPVERPLLSMEAWLTLIGM
                     ELGLPTGYRELRAGTILQDVYPSPNAHYLSSETSETLLEFHTEMAYHKHQPHYVMLACS
                     RADHEGTAATLVGSIRKALPRLDRATRAELYRKPMRCHVDMAFRPGKDTDPLYQISVLD
                     GHREDPLLAYDRELLDPVDLPAKRALAELSDALDAVTEPVHLKPGSLFIVDNYRTTHAR
                     TPFTPRWDGKDRWLHRMY"
     gene            13649..14806
                     /gene="argJ"
                     /locus_tag="IGS71_RS10000"
                     /old_locus_tag="GCM10017557_20610"
     CDS             13649..14806
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /GO_function="GO:0004358 - glutamate N-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1220: bifunctional ornithine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552882.1"
                     /locus_tag="IGS71_RS10000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20610"
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="WP_190850018.1"
                     /transl_table=11
                     /translation="MTTLLLPRGFSTHTGRSGIRDDRDDFLVVASDVPAAVSAVFTRSR
                     FAGPSVVLSRAAAASMTGRGVIALSGNANVATGEGGLSDAREVRAGVARALGVADDELL
                     ITSTGLIGRRYPMPAVRDHLATLEYPFGGADFEAAAKAFMTTDTRHKVRSARCGTASLV
                     GIAKGVGMMEPNMATLLTFFFTDAELEPGVLDTVFRRVIDRTFNALSIDTDTSTSDTAA
                     VFANGLAGPVDVAEFERELFGVALGLVKDIARDGEGATKLIEVAVTGARDSEQARRVGK
                     TIVNSPLVKTAVHGADPNWGRVAMALGKCEEDTDIAPENVTIGFGEVDVYPEPPDQGRL
                     SQVAKHLKGDEVVIRVGLGTGHSAFRVYGCDLTEGYVRLNADYST"
     gene            complement(14832..17978)
                     /locus_tag="IGS71_RS10005"
                     /old_locus_tag="GCM10017557_20620"
     CDS             complement(14832..17978)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="IGS71_RS10005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20620"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_079103671.1"
                     /transl_table=11
                     /translation="MSVRIASAPISLHQDDKTTSPHHEAAINVFGKLTIQFTGQPLEIG
                     PPRRRAVLALLVMRARTVVSIPTILEGLWGTDLPGHAVTTLQSYVSRLRKLIVHHPLAD
                     GSKLTLQYRSHGYVLDIAPENIDAVRFEQLVTKGLAAERRGDWSHAFALLSSSLREWTA
                     PPFEDLSEYDFARQEARRLSQLRLSAVEGRADAALRLGRSGEILHDLEAEAVHNPARER
                     LVGLLMQAQYRDGCQADALQLFDRTRRHLSVELGVDVGPELRRTHEEILRHAPSLAPVE
                     VPAPAAPAKAAEPVASTPTLGRLPFIGRQKELEVLWAAADRACNGRGGVVSLLGEAGSG
                     KTTLLREFRRHCAEREIDVLTVNCPRADALPAHWPWKQVLRAAAERWPQTINALPPEVR
                     ATLVAMLPGWQQASEHTRSAPHPVGDFPVQEAVAQTLLALGGRPLVLVVEDLHWADVAS
                     LRLLLFLASQLADSRLLLVATSRTFRANADPDMRALLAAIRELPVSDEIILGGLDAGES
                     RELARAMGQHLTDASADALHRRTVGNPYFLIAMLKHITPDTSAAAVGSLLPEALEEVAL
                     ERMALLPGLVNDVLRACTVLGDDCTEPVLSGVLGDGDDGPDAAIQQAIRGGLLTPVFGG
                     PRLAFVHPLLRDTVRRNLSRGELGKLHWRAVPALLHGAQLFDVRDSVGAHVRAALRSVP
                     PEQVLRPLLDEAEKAVKFGLYAVGSEWLDLLADIFRSPDGDQWYTQAELNVQLRRLDLL
                     NILQETVPASRDTVRARVEQLGYQLGSLQAGAVLPSRLIGQLTRGDLPDAEATASLLLG
                     LAQEENDPYLEFVAHYGRGRVRYARGELTDARAAMDDALAVAGHRAADCGAVTPCWLYL
                     CARLSKTLIQWLQGRADEAWQDMAEIRHAQCYSGAGPVAPSLVYTCQAVLQVFEDDPQK
                     AERQAIAAAEPTRRKGTYRWQWLIDAVLLWAKARQGSARPVDFAAARSSLARAELGGTR
                     LITLGLALVSDAERVAGRPREAHAYLRRLRRLVAQTGEVVYLNALPAHLLPWRALPHAA
                     "
     misc_feature    complement(16047..16049)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17256..17258)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18085..18099
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.67"
                     /tool="antismash"
     misc_feature    18225..18239
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.34"
                     /tool="antismash"
     gene            complement(18252..19247)
                     /locus_tag="IGS71_RS10010"
                     /old_locus_tag="GCM10017557_20630"
     CDS             complement(18252..19247)
                     /NRPS_PKS="Domain: Abhydrolase_1 (38-157). E-value:
                     1.7e-14. Score: 46.0. Matches aSDomain:
                     nrpspksdomains_IGS71_RS10010_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961113.1"
                     /locus_tag="IGS71_RS10010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20630"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_055514591.1"
                     /sec_met_domain="PF00561 (E-value: 5.6e-13, bitscore: 48.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVATYRLGDLPLESGEILRDAQITYAMHGQLAPDRRNVVLCPTF
                     FGGDHTGYDWLIGSGRPLDTDRYCVVVPGLFGNGFSSSPSNHPSGSRFPAISSRDNVVA
                     QHRLVTEELGAAELALVTGWSMGAMHAYQWAVSYPQLVARLAPICGSATTSEATRVFLS
                     ALGSALRGDGPAKRRLRAAARVFAGWAASHEFWAERLYRELGFVDRDAYLTGFWDAFFT
                     SRDVDDLLVMVSTWERSDVGATRGYGGSVRTALEAVRADTVLLPGLRDQCFAPQDEAAT
                     ARIVPSSTLSVIPGVWGHLAGSGATAADRDFVAGALGRLLERTRAVAERP"
     aSDomain        complement(18777..19133)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS10010_Abhydrolase_1.1"
                     /evalue="1.70E-14"
                     /label="IGS71_RS10010_Abhydrolase_1.1"
                     /locus_tag="IGS71_RS10010"
                     /protein_end="157"
                     /protein_start="38"
                     /score="46.0"
                     /tool="antismash"
                     /translation="VVLCPTFFGGDHTGYDWLIGSGRPLDTDRYCVVVPGLFGNGFSSS
                     PSNHPSGSRFPAISSRDNVVAQHRLVTEELGAAELALVTGWSMGAMHAYQWAVSYPQLV
                     ARLAPICGSATTSEA"
     gene            complement(19440..19754)
                     /locus_tag="IGS71_RS10015"
                     /old_locus_tag="GCM10017557_20640"
     CDS             complement(19440..19754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018528235.1"
                     /locus_tag="IGS71_RS10015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20640"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_055514589.1"
                     /transl_table=11
                     /translation="MTTMVLAVAALAIGTYITRLAGPLLYHRLTLPAAVVRLLPIMAAV
                     PLTALCVTGALTEAGSFAGWARPAGVAVALVLALRRTSFAVIVIAAAGTTALLRLCGVP
                     "
     gene            complement(19751..20464)
                     /locus_tag="IGS71_RS10020"
                     /old_locus_tag="GCM10017557_20650"
     CDS             complement(19751..20464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079354.1"
                     /locus_tag="IGS71_RS10020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20650"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_055514587.1"
                     /transl_table=11
                     /translation="MTQNEQAVDREMWSALGALSAAAAVIGVSFGAIAVASGVPGWLAI
                     AMSVFIHAGGAQFLSAGLLAVGNPVAAVVGGLLLNARHLPFGLALRDTLGDTWWARVAG
                     SQLISDESVAFALSRPEGPARRRAFWACGIALTFAWDGGTVVGVLLAGSVGDPNALGMD
                     TAFPAGLLALVLPSLRDRTTRDAALLGSALALLTTPLLPAGIPLMLSLAALALPALTSL
                     RRDDPVSNTGEEGLR"
     gene            complement(20505..21671)
                     /locus_tag="IGS71_RS10025"
                     /old_locus_tag="GCM10017557_20660"
     CDS             complement(20505..21671)
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-371). E-value:
                     2.4e-63. Score: 206.4. Matches aSDomain:
                     nrpspksdomains_IGS71_RS10025_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963435.1"
                     /locus_tag="IGS71_RS10025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_20660"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_055514641.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3e-61, bitscore:
                     206.5, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.5e-14,
                     bitscore: 50.5, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLNKTLLSQRAAGLTPLSVGRLAATARERGAVDLASGVPLGNPP
                     EAVLAAATAAMRAGHNQYAPGAGSPQLRAVVAERLRRDRAAVVDPEHEVTITSGATEGV
                     LAALLTCVDPGDEVLVPEPWFESYPGAVRLVGAVPRPVPLTSDGWRLDIDVVRAAITPR
                     TRAILLNTPHNPTGRVFSAAETAALMEVCVRQDIVCITDEVYDNFVFGRSEMTSPLDLP
                     SAREHVIAVGSFSKSLQMSGWRLGYCVASPALTAGLRRVVERTTVCAPTPLQEGAAAVS
                     TASSGAENFRSTREAMVERLAEAGMEVSPPEGGWFVFARIDRVTPLPAGEFATRLLDEA
                     GVLVAPGSAFFADPRDGDRWIRTCFVRDFEIMDQGMKRLENYLRPAAW"
     aSDomain        complement(20559..21575)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS10025_Aminotran_1_2.1"
                     /evalue="2.40E-63"
                     /label="IGS71_RS10025_Aminotran_1_2.1"
                     /locus_tag="IGS71_RS10025"
                     /protein_end="371"
                     /protein_start="32"
                     /score="206.4"
                     /tool="antismash"
                     /translation="VDLASGVPLGNPPEAVLAAATAAMRAGHNQYAPGAGSPQLRAVVA
                     ERLRRDRAAVVDPEHEVTITSGATEGVLAALLTCVDPGDEVLVPEPWFESYPGAVRLVG
                     AVPRPVPLTSDGWRLDIDVVRAAITPRTRAILLNTPHNPTGRVFSAAETAALMEVCVRQ
                     DIVCITDEVYDNFVFGRSEMTSPLDLPSAREHVIAVGSFSKSLQMSGWRLGYCVASPAL
                     TAGLRRVVERTTVCAPTPLQEGAAAVSTASSGAENFRSTREAMVERLAEAGMEVSPPEG
                     GWFVFARIDRVTPLPAGEFATRLLDEAGVLVAPGSAFFADPRDGDRWIRTCFVRDFEI"
     gene            21875..22705
                     /locus_tag="IGS71_RS10030"
                     /old_locus_tag="GCM10017557_20670"
     CDS             21875..22705
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS10030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_20670"
                     /product="2OG-Fe(II) oxygenase"
                     /protein_id="WP_055514585.1"
                     /transl_table=11
                     /translation="MKPTDADHLIRNTEVVQQVDPLFDAETTSPLNREALLRLAAGTLG
                     AIRVPDMLTPEGCVQLCAQLDGTEFSTYDERRIWPPIAKFGPAVYDYYLDGQLRPEYWQ
                     DARKAEEQWAKATGADDPMEALIAQIAEAWDGPVSRATVGGRSLFAGMVRELKGDPRMH
                     FDEVVREFPGVFDHTPIAQLGFNCYISLPEDGGELNVFRRRWRPTDDEDRIGFGWSQTI
                     VAREPHLTLTPELGEGIFFDTRNYHFITPSTKGRRLTLAFFVGVTADNRLIIWA"
     misc_feature    complement(23279..23289)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 ctcccacgac aggaacgaat gtccgccaag gatacgagcc cgtcggcaaa cgccctgagg
       61 gctgtcccgt cggggattac gggacagccc ttggcagcga caacgccgtc cgcatgcccg
      121 cgagttccac ggccgccgcg tactggcgat tgtggctgcg cccgaacgga aaggagatcc
      181 gtgccggtcg ggcgcatccg gacctgcgga gaagcggggt gtggatcagt cgaccacggc
      241 caggacgtcg atctccacca gcatgccggg cggcaggccg acgaagacgg tcgtgcggca
      301 cgggaagggc tcgctgagga acttcgcgta cacctcgttc atcggtgcga agtcggcggc
      361 ctgggtgatg tagatccgca cggtgacgac gtcggcgaag gaggcaccgg aatttttgag
      421 gatgttttcc agattggtga gcgtctggcg ggtctgctca gcgattccgc cttccaccag
      481 cttgttgttc gccggatcga gaccgacctg accggacacg gagacaatgt tgccgcggcg
      541 gaccgcctgg gagtaggggc ccaccggagt gggcgcgttc tcggtagtga acacctgcgt
      601 cttcatggaa cctcctgtga cggaatgtgg tcgccatcga cagtgccacc gggtccttgc
      661 gattccctgg gcttttgctg acacccccgt cggtccgccg gacgtccacg gtcagcggtc
      721 cgcaagcgat cgctggcaga gtcggcgccc gtcagcggcg cccctccggg cccgcccttg
      781 ccctgaaacg aggtgcaggc gatgcatacg gacgccactc cggtggacat cgacaccggg
      841 aaccgcgcta caccctcccc cctcctgacg gaacaggacc tcaagtcggc cgcagcccgg
      901 ctgaccggcc gggtgctgaa gaccccgctc ctgccctgtg aggagctctc tctcgcgttc
      961 ggctgccagg tgctgctcaa ggccgagaac ctgcagcaca ccggtagctt caaagtccgg
     1021 ggagcgacca acgcgttgct cgcccgcggg gagaggggcg agcggccttc ccacgcggtg
     1081 acgttctcgg ccggcaacca cggcgccgcg ctcgcctacg cgagccgtcg gctcggtgtc
     1141 cccgccaccg tcttcgtccc gccgggcgcg gtcgccacca agatcgacgc gatacgacgg
     1201 cacggtgcca ccgtcatcga gggcgaggac ttcgtcgccg cggcacagcg gttcgccgag
     1261 cgcaacggcg cgctgctgct gcaccccttc gacgacctcg acgtgatcgg ggggcagggc
     1321 acggtgggcc tggaggtctg gcaggccctg ccgtgggtgg acgtcctgtt ggccccggtc
     1381 ggcgggggcg gtctgctgag cgggatcggt gccgcgttcg ccgcgctctc gccgagcacg
     1441 cgggtcgtcg gcgtggaacc cgctgcggcc cgtgccctcg cacacgccgt cgagtccggg
     1501 ggacccgtgt ccctgccgac cgcgccgacg tcgatggccg acggcctgaa cgcgccgttc
     1561 gccggcactc acacctacca ccacgtcctg caccacaccc atcaactcgt ccaggtgtcc
     1621 gaggaggaga tccgcctggc ctggatcgat ctgatgcggg cgacccgtct gatcctcgaa
     1681 ccgtcggccg cggtgggcct ggccgcgctg cgcaccggag aggtcgccgt gcctgcgggc
     1741 ggggtcgtgg tcctggtcct gtccggcggc aacaccgacc tcgcgtccct cggcgcggcg
     1801 agccgggcgg tctgacagcc cggtcccggc tccttcgcgg cagaccacag agcacgaggc
     1861 cgtttccccg ggagtgggga aacggcctcg tgctccgagc aggaccggta ccggatcagt
     1921 cgaggaccgg ggccgggcag ggtgcgaacg ccccgaactc tccccgcagg aagagcagcg
     1981 gttccccctc gtgctgcacc tggaaccggc ggacatgacc ggtcacgaac cagtggtcac
     2041 cggcctcggt ctcgtccgcc agatcgcagt cgatccaggc gatcgccccg gagagcaccg
     2101 gcgccccgga cggcgccggg tggtggggca cctcccagcg cgtggtgtcc cgggaggtga
     2161 aggccaggca gacctcgcgt tggtccgctc ccaggacgtt cacgcagaag ctgcccccgg
     2221 cgcggatgcg tggccaggag gtcgacgcct tcgagggcag gaacccgacc agcggtggat
     2281 cgagggagac cgaggtgaac gtccccacta tcatccccgc cggcggctcg ccggcgctgg
     2341 tgacgagggc caccccggtg gggtaatgcc cgagcaccga ccggaacagc gtggcgtcga
     2401 gtgtgccggg gatcaccgag aggcgagggg cgcgagcggc cccgcgaagg cgacccccgg
     2461 gtaggacagg gcgagggtgg agacgtcctc ggcgatctcc ttgaccgcct cgccacgcag
     2521 cagcagccgg gcgagcaggt cggccaccac gctcatgtcg ctctcccgca tgccccagcg
     2581 ggtcagttcc tgggtgccga gccgcagtcc gggccggccg gtgctgggca gctgcacggt
     2641 cgtggaccgg ataccggccg cggtcagggt cctcccccac tggtgcgtgg tgtgcccgtc
     2701 gggcaggtgg acccacacct ggtgggtttc ggagtaaccg aagtccttcc cggccacgtc
     2761 gaagccgcgc gacgccagct ggctgcccag cgcccgggcg ttgtcgatga cctgctgggc
     2821 ataggccgta cggtgcggca tgagttcctc aagcgtgatc gccagggacc cgacgctcgc
     2881 ggagtgcgaa ctcgacgccg tgaaggggat gcgggcaccg accagctccg ccatacggtc
     2941 gctgttggtg acgagcagac ccttctgcgg tcccggcatc gtcttgtggg tgctgccgga
     3001 gatactgtcg aagcccccgt ccaggaccag cgtctgcgga gccaccggca gcaggcccag
     3061 cagatgcgag gcatcgaggc agatcagcgc gtcgggcgcg gcggcccgaa gagcgcgggc
     3121 gtccgggaag cgcagcatcg aggaagcgtc gagatagatc aggtcgacgg ggcgctcggc
     3181 gaccgtggtg gccagcttgg cgtagtcgat ctccagagtg ccgcggtcga acggcaggaa
     3241 gtcgacctcg tgaccgtagc cccggcagat cgtcgccgtg gcgtagtggc cgccgtcctc
     3301 gggcgccagc accatcaccc ggtcgcccgc cgtggcgaca gcggtgatga cggtgtgcat
     3361 ggtgtgcagg cccgagagga agttcacgta ggcgtgccgg gctccgtaga actgcttcgt
     3421 caggtcggtg cagtaggtga agacgtcgtt cagaccggtg acgtcgccgt acacggcgac
     3481 gtccgtctcc gagtacggat agcggttgtt ggcatcggag gacagcgcct ccagggcccg
     3541 gggggaaagg cggttctcga tcgggaagag gttcaggctg ggttgccggc ggagcgtggc
     3601 caggacgtcc atatcggttc ctccgaacat cggtgatctg tcagtgtcgg gtgccgtcga
     3661 gccaggggta gcgggcggtg tcctggccgg cgtagtcggg atccatgtag atgaaggcgc
     3721 gctggatcag gtcgtcgcgg acctcgaaga ctccgcagaa ccggccgcct ccccactcgg
     3781 gcaggccgac gtgccaggga ccgtcgtgat gctcgccgtg ggtggtgccc tccgccgcga
     3841 gcaggtcggt gccggtcgtc agccagttga aggaccagaa gtgatgggtg atcgacttta
     3901 tcgtcgggcc caggtcgtcg aagagccggg agatctccgg cctgcccttc gccagacccc
     3961 acttggggaa gaagaactgc gcgtcctggg cgaagaagtc gaggacggaa cggccgtcgg
     4021 tgccggtgcc tccgttgtcg aacgccttga ggtacgcgat gacgacggcc ttgcgctgct
     4081 cgtccgtcgc ggcctggttg ctcggcatgg ttctcctcgt cgtcgtacct gcgggagtcg
     4141 tgatccgctg gggaaagggg aaggtcagag ccagttgggc gcgatctcgg tggcccacag
     4201 ctccaggctg cgcatctgca cgtcgtgcgg gatcggcccg gagtactggc actgcagcag
     4261 atactcaggg gtgtggtgct ccacgagccg ctcgatcttg cggttgatgt cgtcgggcgt
     4321 gcccacccac tccaggcccc gctcgaccag cgtgtcgtag tcggagccga tgggcccggt
     4381 ctcgccggtg ttgcgcagtg cctcggtgaa gcccatggga ccgaaccagt tgtcgaagat
     4441 gaaaccgcct ccatggcgcg cccagtggtg tgcctcctcc ttgttccggg acaccagcac
     4501 gtcccgcatc accccgacgc tctcaccgcg agccagtcgg ccccggccgg ccgcctccgc
     4561 ctcctcgaca tagacgtcga gcagctcgcc caccctcacc gggtcggtgt gcatgacgat
     4621 ggggacgacg ttctcccggg cgcagaaccg gaaggtgtcc tcgctgaagc tgaacggctg
     4681 gaacaccggc ggatgcgggt tctggtaggg ccgcggcgcg atcccgacct cgacgatgcg
     4741 gccggcgtcg tcctggccgc ggccgaagcg acgcacggcg tcgtagggga actccaggtc
     4801 cttcggcggg atggtccact gctcgccctc gtgcgtgaag gtctcgttcg tccacgcctt
     4861 tttgatgatc tcccagtgtt cctcgaacag tcgccggttg cgccggtcgc tctcgctgcg
     4921 gtcggagagg gtgccgccga cgccgtacac ctgccccatg acatcggccc agcggcgctg
     4981 gaagccgcgg gcgatgccca cgaaggtgcg gccacgcatc atgtgatcca gcatcgacag
     5041 gtcttcggcg agccggatgg gattgtgcag cggcagcacg ttcgccatct gcccgatgcg
     5101 gatgttcttg gtctgctgac ccaggtacag gccgagcaga atcgggttgt tcgagacctc
     5161 gaaaccctcg atgtgaaagt ggtgctcggt gaaggaagcc ccccagtagc ccatttcatc
     5221 ggccgcgcgc acctggtggg tgagctgcct gagcatgttc tggtaattgg caggatttgt
     5281 gcccgccatc ccccgggtga tctgcatatg gctgcccgta ctcggcaggt agaacaaaat
     5341 ggatttcacc gctggttctc ctctctcgct ggtcgatgtc cgtgacagac attcccaggg
     5401 ccggtttgcg gacagctgga tccgccgcat gcgcaggcat tggcaggact cgtccaactg
     5461 ggggcagtcc gggttcgtga cactgggcgc gggtgacagc cggccgctgt gcccgcatcc
     5521 atgagtcttc ggaggtgctt ttccatgacc gcagctaccg ggatctcccg gtccaggcac
     5581 gccaccggtg agttggtgcg gctggaccgg gaacggatac tgcacccgct cctgcccgac
     5641 ggcagggagg accgcacggt cctcgtcaag ggagagggct gccgcgtgtg ggacgcggac
     5701 ggcagggagt acctggatgc ctcggccgtg ctcggggtga tgcaggtcgg acacggccgt
     5761 cgcgagttgg cggcggccgc ggccgaacag ctgggcaggc tcgactactt ccacacctgg
     5821 ggcaccatca ccaacgaccg ggccatcgag ctggcgacgc gcctgaccga cctggcaccc
     5881 ccgggcctgg accgggtctt ctacaccagc ggcggctccg agggcaacga gatcgccctg
     5941 cgcctggccc gctactacca tcaccgcaag ggagcgtccg ggcggaactg ggtcctctcc
     6001 cgccacaccg cctaccacgg catcggctac ggcagcggca gtctgtcggg ctcccccgtc
     6061 taccaggacg gcttcggccc ggtcgtcccg aacgtgcact tcctgacccc gccccacccc
     6121 taccagaagc agtggtacgc cggtgaggac cccacggact tctgcgtccg cgagctggag
     6181 gcggcgatcg agaagatcgg cccggagcac atcgccgcga tgatcggcga acccgtcatg
     6241 ggcgggtacg gtgccgtcgt accgcccgcc gactactggc cgcgcgtcgc cgaggtgctg
     6301 cgccggcacg gcatcctgct gatcttcgac gaggtcgtca cggcgttcgg gcgcaccggc
     6361 cggtggtaca gcgccgagca cttcggcgtc gtaccggaca tcctggtgac cgccaagggc
     6421 atcacctcgg gctacatccc gcacggcgcg gtgctggtga gcgaggaggt ctccgaggtc
     6481 gtcggggcgg agggcggctt cccgatcggc ttcacctaca ccggtcaccc gaccgcctgc
     6541 gcggtcgccc tcgccaacct cgacatcatc gagaaggagg ggttgctcgc caacgccacc
     6601 gggacgggcg cgtatctcgc cgccgggctg cgcagcagac tgctcggcct gcccgcggtg
     6661 ggtgacgtcc ggcagatcgg gctgatgctc gccgtccagc tggtgtccga ccaggagacg
     6721 ggcgccgacc tgcccggtgg cacgctgcgg gtcgccgacg cactgcgcga acaggcgggg
     6781 atcctggtcc gcaacaacgc gcacgcgctg attgtctccc cgccactggt actcgaccgg
     6841 ggtaccgccg acaagatcgt cgacggcttc cgcttcgtcc tcgaacggct cggaacggac
     6901 ggctccgtcc gctgacaccc gactgccggc acccaactgc gggcacacct cccgcaggca
     6961 cattccttca ggcgccgggc gccccgggaa cagtccaccg acaagcacat ggccgcgccg
     7021 ctccccgtcc gtcagcaagg gggagcggcg cggccgctgt cgtaccgccg gggtcaggtg
     7081 cccgtcatcg ccagcatctc gggacggtag cgctcaccgt gcacgcgcag ggccgccacc
     7141 tcccgcaggg ccgccgactc gctggggccg agggccagcc gggtggcggc gaggttgtcg
     7201 gcgaggtggg ccggggacgt cgtgcccggg atggggatca cgtccgggcc ctggtgatgc
     7261 agccaggcca gggccagaca cgcggccgac acgccgagcc ggcgggcgag tgtgtcgagg
     7321 cgtcgcacga tcgccaggtt gcgctccagg ttcgccggct ggaaccgcgg caggttctgc
     7381 cggaaatcgt ccgcggtcag ctggctgtgg tggcggatcg cccccgtcag gaagcctcgc
     7441 ccgagcggtg cgtaggccac caggccgatc ccgcgctccc ggcagacgcc caccacctcg
     7501 tcctcgacat cccgcgacca cagactccac tcgctctgca ccgcggtcac cggaaagacg
     7561 gcgtcggcac gccgcacact gtcggcagac ggctccgaca gcccgaagga gcgcaccttc
     7621 cccgcccgta ccaactcggc caccgctccg gccgtctcct cgaccggtac ctcggggtcg
     7681 atccagtgct ggtagtacag gtcgatccgg tccgtaccca ggcgccgcag cgaggcgtcg
     7741 catgcctcgc gcacatactc gggccggccg cacagcccca ggaacgagcc gtcgccgccg
     7801 cgccgcatcc cgaatttggt ggcgatcagc acctcgtccc gacggccggc gagcacctcg
     7861 cccagtagtt cctcacccgc gccgagtccc tgtacgtcgg ccgtgtcgaa cagtgtcacc
     7921 ccggcatcca gggcggcacg cagcacagct gtggcctcgg tccgcgtagg actgccgtag
     7981 aagaccgtgg tgggcagaca gccgaacccc tgcgcactca cctccagctg ccgcagtctg
     8041 cgcaggggag gcatggacgg tgatcgcact cgaatctcct cggccctcga tgtcccgtgc
     8101 cgcccacggg agttcccgtc cgagatgaca gcgtgccgtg gtggcgaagc gctggacggt
     8161 cggcaccgta cgcgggggca agccggaggt ccacccgaac gcaagaggcc gtaccgacag
     8221 tggttggtga tcgccgcggc gcccagcgca ggcggcttcg tacccggcac gcggctctcc
     8281 cccgacgcgt gccctccctg accggatgaa acgaggttcc tcatggccag caagaagacc
     8341 gcggagctcc tgctgaggcg gctgcacgag tacggcgtgg accatgtctt cggtgtcgtc
     8401 ggccgggagg cggaggccat cctcttcgac gaggtggacg ggctggagtt cgtcctgacc
     8461 cggcacgagt tcaccgccgg tgtcatggcc gacgtgcttg cccgcctgac caaccgcccg
     8521 caggcatgct tcgccacgct cggccccggc atgaccaacc tgtcgacggg tgtcgccacc
     8581 tcggcgctgg accgcagctc ggtgatcgcg atggcggccc agtccgagtc gcacgactgc
     8641 ttccccaacg tcacccacca gtgcgtcgac agcgtcgccg tgatggcgcc cttgaccaag
     8701 ttcagcgccc agctggagcg ccccgccgac atcacgtccc tggtggacac cgcggtcctg
     8761 cacagcacca cggagccggt cggcccgagc ttcctcagtc tgcccatcga cctgctgggc
     8821 gccgacgtgc ccgaggacgc cgcccaggcc gcccccgtcg tcggttaccg caagaaggcc
     8881 gtcgtcgacc cgacctggac cgagctcgtc cccggcatcg ccgacaagat cgccgccgcg
     8941 aagcaccccg tcctcgtcgt cggcagcgcc gtgatccgtg ccgacggcgt cgacgcgctg
     9001 cgctccttcg ccgagcggtt gcgcatcccg gtcgtcacca cctacaccgc caagggcgtt
     9061 ctgcctcacg accaccccct caactacggt gcgatcagcg gctacatgga cggcatcctg
     9121 tccttctccg ccctcgacca gatcttcggc cccgtcgacc tcatcgtcgc cctcggctac
     9181 gactacgccg aggacctccg gccctccatg tggacccgcg gcaccgagaa ggaggtcgtc
     9241 cgggtcgccg ccacggtcaa ccccatcacg gccctcttcc gccccaccgt cgacgtcgtc
     9301 gccgatccgc gtgaggtcat cgagaccctg gacaaggcca ccgcccacct catggcgaag
     9361 accccgcacg acatcgagcc gctgcgcgcc cgcgtcgccg agttcctcgc cgacgacgag
     9421 gagtactccg acggcatgcg cgtccaccag gtcatcgact gcatgaactc ggtcctggaa
     9481 aacggcacct tcgtcagcga catcggcttc ttccgccact acggcgtcct gttcgccaaa
     9541 gccgaccagc cctacggttt cctcacctcc gccggatgca gcagcttcgg ctacgggctg
     9601 ccggccgcca tggccgccca gatcgcccgc cccgacgagc ccgtcttcct catcgcgggc
     9661 gacggcggct tccactccaa cagtgccgat ctggagaccg cggtccgcct cggtctgccg
     9721 ctggtgatgg tcgtcgtcaa caacgaccgc aacgggctca tcgagctcta ccagaacaag
     9781 ggccaccagc gctcgcacgc ccccgccgtc gccttcagga gcgtcgactt cgtccaactc
     9841 gccgaggcca acggctgcga cgccgtccgc gccaccgacc gcgagtcact ggtccaggcc
     9901 ctgcgcaagg gcgccgagct gggccggccg ttcctgatag aggtgcccgt ggcctacgac
     9961 ttccagtccg gtggcttcga ggccctggac atctgacgcc atgatgggac ccaatcttgt
    10021 cgcgggcttc tgggcgcgcg tgtcgtggtc gccacgccgc gccgcgccgg aaaccccccg
    10081 cttcgcgact cagggccata cgagcgctgt ctcggcggcg agcgcgggcc gccacctcca
    10141 aggggtcgcc gtcagtttcg gcgcccccga caccctggtc tccgacggcg gcatccacct
    10201 gctgctcgcc ggcgagatct acaaccgcga cgaggtcgcc aaggcactcg ggaacgcctc
    10261 cgccgcccac ggcagcgacg ccacgctcgt tctggccgcc tggcaccact ggggcatcac
    10321 cgcgttccgt attctcaacg gccgcttcgc cgccctcctc ctggacggcg gcgggcgggt
    10381 cgtcgtggcc accgaccacg ccggctcggt cccgctctgg ctgcgcgccg acgcccacgg
    10441 tgtcgacgtc tccaccgagg ccaagacgct cgccgggctg cccggcaccc ccctggacgt
    10501 ggccggcgcc cagttgctgc ccggcggtac gggggtgcac cgcgtccagg cgggtaccgc
    10561 gctgattctg gagaccgtgc agggcgaggt gcggacagcg aaccgggtgt acacctggac
    10621 ccccccggtg tcacgggccg ccgtcggcga ggagatcgcc gtcggccggg tgcgcaggct
    10681 cctcgcacag gccgtccaga cccggctgcg ggacgatccg gagccgaccg tggtgctctc
    10741 cggaggcatc gactccagtg gcgtcgcggc gcacgcggtc gcgcacagcg gcctcgtcca
    10801 ctccgtgtcc atggggaccg aggcctccga cgagttcgga cccgccaagg tggtggccgg
    10861 ccacctgggc accgaccact ccgagatgac gatccacagc tccgacctgg tgcgggagct
    10921 cccctgggcc gtgtgggccg cggagatcgc cgaccacacc atcctggagt acctgctgcc
    10981 gctgatcgcg ctctaccgca gactgccgcc cggcccacgg cgtgtcctga ccggctacgg
    11041 cgccgacatc ccactgggag gcatgcaccg gcacaccgaa ccgctggacc tcctggactc
    11101 cgtcatcgcc cacgacatgg ccacgttcga cgggctgaac gagatgtccc cggtcatctc
    11161 gggcgtcgcc ggcatctggt ccacgcatcc gtactgggac cgcgacctgc tcgactgcct
    11221 gatctcgctc gaccccggtc tcaagcgccg ctacggccgc gacaagtggg tgctccgcga
    11281 ggccctggcc aggatgctcc cggccgagac cctgtcgcgg cccaagctcg gtatccacga
    11341 ggggtccggc acctccagcg cctggaccgc cctcctcctg gagaagggcg tgccacccgg
    11401 gcgcgtcgaa cagtgcaagg cggccatggc ccggcgcatg cacgatctga tcgtcctgcg
    11461 cacccggcac cccgacgaga tctccttcga cgaggtcctc gcggccactg agaaaggacg
    11521 gacccgccat gcactcgaac aatgacggca gcgacttcgc gacgtccggg aagacccagc
    11581 tcagcagcgg ttcctcgcct cgatacgcgc aactcgccac cttcatgcgg ctccagcacg
    11641 atccgagccc ggtgggccac gacgtcgtgg tgatcggtgc cccctacgac ggaggcacca
    11701 gctaccggcc cggcgcccgt ttcgccccgc gcgccatccg gcacgagtcg tgcctcatcc
    11761 atggcaccgg catcgaccgc ggccccaatg tgttcgacct gatcgacgtc gtcgacggcg
    11821 gcgacatcga cctcagcccg ttctcccagg acatcgccat ggagacggcg accgaggcgc
    11881 tcacgggact gctctcggac aacgacgcgt tcctgatgct cggcggggac cattcgctgt
    11941 ccctggccgc gatgcgcgcc gtgcacggcc ggcacggccg cctcgccgtg ctccatctgg
    12001 acgcccacag tgacaccaac ccacccgtgt acggcggcac gtaccaccac ggaaccccgt
    12061 tccgctgggc gatcgaggag ggcctcgccg cgccggatca cgtggtccag ctcggcatcc
    12121 gcggccacaa cccccggccc gactcgctcg actacgcccg cgggcacggc gtacgcgtca
    12181 tcaccgcaca ggagttcttc acacggtcgc tggacgatgt cgtccgggag atccggtccg
    12241 tggtcggcga cctgcccctg tacgtgtcgg tcgacatcga cgtcgccgac cccgcctacg
    12301 cgccgggcac cggcaccccg gcgccgggcg ggctctcctc ccgcgaggtg ctggcgctgc
    12361 tgtcggtcgt cggcgacctg aaaccggtcg gcttcgacat cgtcgaggtg ctgcccaccc
    12421 acgacccggc cggtatcacc gctctgctcg ccgccgaggt cggcgccgag ctcctctacc
    12481 agtacgcacg cggcacggga cgggcacggg caacggcgcc cgcgccggcc cggccacgca
    12541 tcacccgtcg agccacgtcg gaaggaaccg acatgatcac cacacgaccc gagatcgtgc
    12601 actgcgagga cgactccgct cgcctcctcg aactgcgtga acggctgccc caaacgcccc
    12661 gcctcgacat gagtgacttc ttcgcgaccg cgggcgcact gtcacaggaa ctgccggagc
    12721 acctgcgcgc cgccctgcgc gacttccgcg ccaccggcaa cgaggccggg tacctgatgc
    12781 tgaccggcct cccggtcagt gacgaggagc tgcccgagac ccctaccagc accccggcgc
    12841 cggtggaacg gccgctgctc tccatggagg cgtggctcac cctgatcggc atggagctgg
    12901 gcctgccgac cggctaccgg gagctgcgcg cgggcaccat cctccaggac gtctatccct
    12961 cgccgaacgc ccactacctc tcctccgaga cctccgagac cctgctggag ttccatacgg
    13021 agatggccta ccacaagcac cagccgcact acgtgatgct ggcctgctcc cgcgccgacc
    13081 acgagggcac ggccgccacc ctggtcggct ccatacgcaa ggcgttgccc cgcctggaca
    13141 gggccacccg tgcggagctg taccgcaaac ccatgcgctg ccatgtcgac atggccttcc
    13201 gccccggcaa ggacaccgac ccgctctacc agatctccgt cctcgacggc caccgcgagg
    13261 acccgctgct cgcctacgac cgggaactgc tcgacccggt cgacctgccc gccaagcggg
    13321 ccctggcgga gctgtcggac gccctcgacg cggtgaccga gccggtgcac ctgaagccgg
    13381 gtagcctctt catcgtcgac aactaccgca cgacgcacgc ccgtacgccg ttcaccccga
    13441 ggtgggacgg caaggaccgg tggctgcacc gcatgtacgt ccgggttccg gagcgcatga
    13501 ccgacagcac cgcccagatg ggcgacgtcg tcgacttcgt gggccggtga ggtagcaccg
    13561 acctggacat actccgacgg ggccggccac cggggcggcc tcgtcggagt gcgatcaccg
    13621 cgaacttcag agaggaacca ggcccaagat gaccacactg ctcctgccgc gggggttttc
    13681 cacgcacacc ggacggtccg ggatccggga cgatcgtgac gacttcctcg tcgtggcctc
    13741 cgacgtgccg gccgctgtca gcgcggtgtt cacccgttcc cgcttcgccg gccccagcgt
    13801 cgtcctcagc cgtgcggcgg ccgcgtcgat gaccggccgc ggtgtcatcg cgctgtccgg
    13861 caacgccaac gtcgccacgg gcgagggcgg gctcagcgac gcgcgcgagg tccgggcggg
    13921 cgtggccagg gccctcggcg tcgcggacga cgaactgctc atcacctcca cgggcctcat
    13981 cggccggcgc taccccatgc ccgcggtgcg cgaccacctc gcgacgctgg aatacccctt
    14041 cggcggcgcg gatttcgagg ccgccgccaa ggcgttcatg accacggaca cccggcacaa
    14101 ggtccgctcc gcccgttgcg gcacggcgtc cctggtcggc atcgccaagg gcgtcggcat
    14161 gatggagccc aacatggcga ctctgctgac gttcttcttc accgacgccg aactcgaacc
    14221 cggtgtcctg gacaccgtgt tccgccgggt gatcgaccgc accttcaacg cgctcagcat
    14281 cgacaccgac acctccacca gcgataccgc cgcggtgttc gccaacggcc tggccgggcc
    14341 cgtggacgtc gcggagttcg agcgggagct gttcggtgtc gccctcggcc tggtcaagga
    14401 catcgcccgc gacggcgagg gcgccaccaa gctgatcgag gtggccgtca ccggcgctcg
    14461 tgactccgaa caggcccgcc gggtcggcaa gacgatcgtc aactccccgc tggtgaagac
    14521 cgccgtgcac ggcgcggacc ccaactgggg gcgggtggcg atggccctcg gcaagtgcga
    14581 ggaggacacg gacatcgccc ccgagaacgt caccatcggc ttcggtgagg tcgacgtcta
    14641 ccccgagccg cccgaccagg ggcggctctc gcaggtggcg aagcatctca agggcgacga
    14701 ggtcgtcatc agggtgggcc tcggtaccgg ccactccgcc ttccgcgtgt acggctgcga
    14761 tctgaccgag ggttacgttc gtctgaacgc cgactactcg acctgaccgc agccgtcgcc
    14821 gctacaggcc gtcaggccgc gtgcggcagt gcgcgccacg gcagcaggtg cgccggcaga
    14881 gcgttgagat acaccacttc acctgtctgg gccaccagcc tccgcagtcg ccgcagatag
    14941 gcgtgggcct cgcgcgggcg cccggcgacc cgctcggcgt cggacaccag cgcgaggccg
    15001 agcgtgatga gcctggtgcc acccagctcc gcccttgcca gggagctgcg cgcggcggcg
    15061 aagtcgaccg gacgtgccga gccctgccgg gctttcgccc agagcagcac ggcgtcgatc
    15121 agccactgcc agcggtacgt ccccttccgc cgggtcggct cggcggccgc gatcgcctgc
    15181 cgttcggcct tctgagggtc gtcctcgaag acctgcagaa ccgcctggca ggtgtacacg
    15241 aggctggggg cgaccggtcc ggcgccgctg taacactgcg catgccggat ctcggccata
    15301 tcctgccagg cctcgtccgc gcgcccctgc aaccactgga tcagcgtctt gctcagccgt
    15361 gcgcagagat acagccagca gggcgttacg gcgccgcagt ccgctgcccg gtggccggcc
    15421 acggcaagcg cgtcgtccat cgcggcccgg gcatcggtca gctcgccccg ggcgtagcgc
    15481 accctgcccc ggccgtagtg ggcgacgaac tccaggtacg ggtcgttctc ctcctgggcc
    15541 aggcccagca ggagagaggc tgtcgcctcc gcgtcgggca ggtctccgcg cgtcagctgg
    15601 ccgatcaggc ggctgggcag gacggccccc gcctgcaggg agcccaattg gtatcccagt
    15661 tgctccaccc gggcccgcac cgtgtcccgg gacgccggga cggtctcctg gagaatgttc
    15721 agcaggtcca ggcgtcgcag ctgtacgttc agctccgcct gcgtgtacca ctggtccccg
    15781 tccggggagc ggaatatgtc cgccagcagg tccagccatt ccgaacccac cgcatagagg
    15841 ccgaacttga cagccttctc cgcctcgtcc agaagcggcc gcaggacctg ctccggaggt
    15901 accgacctca gggcggcgcg gacatgggca ccgacggagt cacgaacgtc gaagagctgt
    15961 gcgccgtgca acagggcagg caccgccctc cagtgcagct tccccagctc accgcgggac
    16021 aggttgcggc gtaccgtgtc ccgcagtaac gggtggacga acgccagcct cggccctccg
    16081 aacaccgggg tcagcagacc gccacggatc gcctgctgga tcgccgcgtc cgggccgtcg
    16141 tcaccatcgc ccagcacccc gctcagcacc ggctcggtgc agtcgtcgcc gagcacggtg
    16201 cacgcccgca ggacgtcgtt caccagcccg gggagcaagg ccatccgttc gagggcaact
    16261 tcctccaggg cctccggcag caggctcccc acagcggccg cggaggtgtc gggcgtgatg
    16321 tgtttcagca tggcgatcag gaaatacggg ttgccgaccg tccgccggtg gagggcgtcg
    16381 gccgacgcgt cggtgaggtg ctgtcccatc gcccgcgcca gctcgcggct ttccccggcg
    16441 tccagaccgc cgaggatgat ctcgtcggag acgggcagct cgcggatcgc ggccagcaag
    16501 gcccgcatgt ccggatcggc gttggcccgg aaggtgcggg aggtggccac gagcaacagc
    16561 cgggagtcgg cgagctggct ggcgaggaag agcagcagcc gcaaggaggc gacgtcagcc
    16621 cagtgcaggt cttccacgac cagcaccagc ggccggccgc cgagggccag aagcgtttgg
    16681 gccaccgcct cctgcaccgg gaagtcaccg accggatgcg gggcggaccg ggtgtgctcc
    16741 gacgcctgct gccagccggg cagcatggcg acgagcgtgg ctcggacctc ggggggcagc
    16801 gcgttgatgg tctgcggcca gcgctcggcg gcggcccgca gcacctgctt ccacggccag
    16861 tgcgcgggca gggcgtccgc cctcgggcag ttgacggtga ggacgtcgat ctcgcgctcg
    16921 gcacagtggc gccggaactc gcggagcagt gtcgtctttc cgctgccggc ctccccgagc
    16981 aggctcacca ccccgccccg gccgttacag gctcggtcgg ccgcggccca caggacctcc
    17041 agctccttct gccgcccgat gaacggcagt cgcccgagcg tcggggtact cgcgacaggt
    17101 tctgccgcct tggcgggggc cgcgggggcg ggcacctcga ccggtgccag cgagggtgca
    17161 tggcgcagaa tttcctcatg ggtgcgccgc agctcggggc cgacgtcgac gccgagctcc
    17221 acggaaaggt ggcggcgggt gcggtcgaag agctgtaagg catccgcctg gcagccgtcg
    17281 cggtactggg cctgcatcag cagacccacg agccgctcgc gcgccgggtt gtgcaccgcc
    17341 tcggcctcca gatcgtgcag gatctctcca ctccgaccga gccgcagggc ggcgtcggcc
    17401 cggccttcga cggcggacag cctcagctga ctcagacgtc gcgcttcctg gcgggcgaag
    17461 tcgtactcgg acaggtcctc gaacggcggc gcggtccact cccgcaggga ggacgacagc
    17521 agcgcgaagg cgtgggacca gtcgccccga cgctcggccg cgagcccctt tgtcaccagc
    17581 tgttcgaagc gtacggcgtc gatgttctcg ggcgcgatgt ccaggacgta gccgtggctg
    17641 cggtactgga gagtcagttt cgaaccgtcg gcgagtggat ggtggacgat gagtttgcgc
    17701 aaccgggaca cgtacgactg gagtgtggtg accgcgtgtc cgggaaggtc cgtcccccac
    17761 agaccttcga ggatggtcgg gatggagacg accgtacggg ccctcatcac cagcagagcg
    17821 agaactgcgc ggcggcgggg cggccctatc tccaagggct gcccggtgaa ctggatagtc
    17881 aacttaccga agacattgat ggccgcctca tggtggggcg aagtggtctt gtcatcctga
    17941 tggagagaga tcggggccga cgcgatacgt actgacatgc cgtttctcct acagttccgg
    18001 tgcagggcgc caccggttgg ggggtgcgtg gagggcagcg tgctgtgcgg cgacagggaa
    18061 tgcccgtcgg gcttccagag caggcttttt cggacattca ggatgctggc ttcatttgcg
    18121 ggatagattt ccgggacgga tttccgggac acgaaaccac agggcgggct ttcgagtctt
    18181 ctattcccga aaggaaaagt tccgacagtc gatttctgga cgacttctca tttcggaaag
    18241 aggccggaaa ttcacggacg ttcggcaacc gcccgggtgc gctccaacag ccggccgagg
    18301 gcgccggcga cgaagtcacg gtccgccgcc gtcgcccccg agcccgcgag gtggccccag
    18361 acgccaggga tgacgctcag cgtggagctc gggacgatcc gggccgtcgc ggcctcgtcc
    18421 tggggcgcga aacactggtc gcgcagaccg ggcagcaaca ccgtgtcggc tcgcacggcc
    18481 tcaagcgccg tccgcacgct cccgccgtac ccgcgggtcg caccgacgtc actgcgctcc
    18541 caggtactga ccatcaccag caggtcgtcg acgtcacggc tggtgaagaa tgcgtcccag
    18601 aagccggtga gataggcgtc ccggtccacg aaccccagct cccggtaaag ccgctccgcc
    18661 cagaactcgt gggaggccgc ccagccggcg aacacccggg ccgccgcgcg cagccgtcgc
    18721 ttcgcgggcc cgtcgccgcg cagggcggag cccagcgcgg acaggaagac ccgggtggcc
    18781 tcgctggtcg tggcggagcc acagatcggc gcgagccggg ccaccagctg cgggtacgac
    18841 accgcccact ggtaggcgtg catcgccccc atcgaccacc cggtcaccag cgccagctcg
    18901 gcagccccca actcctcggt gaccagccgg tgctgggcca cgacattgtc ccgggacgag
    18961 atagcgggga accgggagcc gctcggatga ttgctcgggg agctggagaa gccgttgccg
    19021 aacagccccg gtacgacgac gcagtagcgg tcggtgtcca gcggtcgccc gcttccgatg
    19081 agccagtcgt aaccggtgtg gtcgccgccg aagaaggtgg ggcacagaac gacgttgcgc
    19141 cggtcggggg ccaactgccc gtgcatggcg taggtgatct gcgcgtcgcg caggatctct
    19201 ccgctttcca ggggcaggtc acccaggcgg taagtggcga cagacatgag ggcctcctga
    19261 gcagtggtgg gcacatgggg tgtgccggaa cggtggcagg caggggcgtc acggaccgga
    19321 gaggtgagat ttccaccttg cgtacggtat tgcgacaaca tcttcccttg gtggttcgat
    19381 cgtcggctga ccagaaagct gctcggacct gtctcgggaa gtcgacctgt accgggaagt
    19441 caggggactc cacagagccg tagcagggcg gtggtgcccg ccgccgcgat cacgatgacc
    19501 gcgaaggaag tacggcgaag ggcgaggacc agagcgacgg cgaccccggc gggccgggcc
    19561 cagccggcga aggaccctgc ctcggtcagc gcgcccgtga cgcacagcgc ggtcaggggg
    19621 acggcggcca tgatgggcag caggcgtacg acggccgcgg gcagcgtcaa ccggtggtag
    19681 agcaacgggc cggccaggcg cgtgatgtac gtgccgatcg ccagtgcggc cacggcgaga
    19741 accatcgtcg tcatcggaga ccctcctcac cggtgttcga caccgggtcg tcgcggcgca
    19801 gcgaggtcag agcggggagg gcgagcgcgg ccagggagag catcaggggg ataccggcgg
    19861 gcagcagcgg ggtggtgagc agggccaggg cggagccgag cagggcggcg tcacgagtgg
    19921 tccggtcgcg cagtgagggc aggacgaggg cgagcaggcc ggcgggaaac gcggtgtcca
    19981 tgcccaaggc gttcgggtca ccgacgctgc ccgcgaggag tacgccgacg accgtgccgc
    20041 cgtcccaggc gaaggtgagc gcgatgccgc aggcccagaa ggcgcggcgg cgcgccggcc
    20101 cctccggccg gctcagcgcg aacgccaccg actcgtcgct gatgagctgg ctccctgcga
    20161 cccgggccca ccaggtgtcg cccagggtgt cgcgaagggc gagaccgaag ggcagatgac
    20221 gggcgttcag caggagtccg ccgaccaccg ccgcgaccgg gttgcccaca gccagcagcc
    20281 cggcggacag gaactgggcg ccaccggcgt ggatgaacac cgacatggcg atcgcgagcc
    20341 agcccggcac accggaggcg accgcgatcg cgccgaagga gaccccgatg acggcggcgg
    20401 cggcactcag cgcgccgagt gccgaccaca tctcccggtc gacggcctgc tcgttctggg
    20461 tcatgtgtcc cgtccagtgc agcaggagga atccgggaag ccggtcacca cgccgccggg
    20521 cgcaggtagt tctccagcct cttcatacct tgatccatga tctcgaagtc ccggacgaag
    20581 cacgtacgga tccagcgatc gccgtcccgg ggatcggcga agaaggcgga gcccggcgcc
    20641 accaggaccc ccgcctcgtc gagcagccgg gtggcgaatt cgcctgcggg cagcggggtg
    20701 acccggtcga tccgcgcgaa cacgaaccag ccaccctccg gaggggacac ctccatgccg
    20761 gcctcggcaa gccgctcgac catcgcctcc cgggtcgacc ggaagttctc cgcacccgaa
    20821 ctcgcggtgc tcaccgccgc cgcgccctcc tgcagcggcg tgggggcgca caccgtcgtg
    20881 cgttccacca cccggcgcag ccccgcggtg agggcgggcg acgccacgca gtaccccagc
    20941 cgccaaccgg acatctgcag ggacttggag aaactgccca ccgcgatcac gtgctcgcgc
    21001 gccgacggca gatccagtgg cgaggtcatc tcggaccggc cgaagacgaa gttgtcgtac
    21061 acctcgtcgg tgatgcacac gatgtcctgt cggacgcaga cctccatgag cgcggcggtc
    21121 tcggcggcgg agaagacgcg gccggtgggg ttgtgcggcg tgttgaggag gatcgcacgg
    21181 gtacgcgggg tgatcgcggc gcggacgaca tcgatgtcaa gccgccagcc gtcggaggtc
    21241 agcggcaccg ggcggggcac cgcgccgacg agccgtacag cgcccggata ggactcgaac
    21301 cagggttccg gtacgaggac ctcgtcgccc gggtcgacac aggtcaggag cgccgccagc
    21361 accccctcgg tggcaccgct ggtgatggtg acctcatgtt cgggatccac gaccgctgct
    21421 ctgtcgcggc gcagacgctc ggcgaccacg gcgcgcagct gcgggcttcc ggcaccgggg
    21481 gcgtactggt tgtggcccgc acgcatcgcg gccgtggctg ccgcgaggac agcctccgga
    21541 ggattgccca ggggtactcc actggccagg tccacggcgc cccgctcacg tgcggtcgcc
    21601 gccagacggc ccacggacaa cggtgtgagg ccggccgccc gttgtgacaa cagcgtcttg
    21661 ttgaggctca tggacattca cggtttcagc cggggcttga gaccggcggg acaaccggtt
    21721 tgactccctc gccctcccct tgtccccgaa cacagtgcgg acgacagcgg gatcgtccaa
    21781 cggactgtcg aagagcctcc ggaggatgga gacccgtggt ggccgtcagg ccaccggagc
    21841 cggtccagac cggccggagt tgaggagacg tgcattgaag ccgaccgacg ccgaccatct
    21901 catccggaac accgaagtcg tccaacaggt cgatccgctt ttcgacgccg agaccacctc
    21961 gccgttgaac cgcgaagctc tgctgcggct cgcggcgggc accctcggcg cgatccgggt
    22021 accggacatg ctcacgccgg agggctgtgt gcaactctgc gcgcaactgg acggcaccga
    22081 gttcagcacc tacgacgagc gacgcatctg gccgccgatc gccaaattcg ggccggcggt
    22141 ctacgactac tacctggacg gccagctccg ccccgaatac tggcaggacg cccgcaaggc
    22201 cgaggagcag tgggcgaagg cgaccggcgc cgacgacccg atggaggcgc tgatcgcgca
    22261 gatcgccgag gcctgggacg ggccggtcag ccgggcgacc gtgggtgggc ggagcctgtt
    22321 cgcggggatg gtgcgcgagt tgaagggcga tccgcggatg cacttcgacg aggtggtccg
    22381 cgagttcccc ggtgtcttcg accacacccc gatcgcccag ctcgggttca actgctacat
    22441 cagcctgccc gaggacggcg gcgaactgaa cgtcttccgc cggcgctggc gcccgacgga
    22501 cgacgaggac cgcatcggct tcggctggtc ccagaccatc gtcgcccgcg aaccgcacct
    22561 gactctcacc ccggaactgg gcgagggcat cttcttcgac acccgcaact accacttcat
    22621 caccccgagc accaagggcc gccgactgac cctggcgttc ttcgtcggtg tgaccgcgga
    22681 caatcgcctg atcatctggg cgtgacccgc tccggaggcc gtgtcggcat actcggcacg
    22741 gccttccgcc atgcggccga gtgcacgcag caggaggtgc tcttcgcctc agctcgcctc
    22801 cacgcccgga tgcgcgagta gccacgtggt caacggttcg gtcggtgcag cgggcgcggg
    22861 cctgttccgt acagcctcgg ccaggtggcc ggcccgtcaa cttccgcaag gcgggcggta
    22921 gttccactgc gggaagtact gtcgccattc ggcgcgggtg atcgcgggga agaccgtgtc
    22981 gcagatccgg tcggcgaccc gttcgatgtc ggggtcccag agcagggcgg tccagtcctc
    23041 gctcccggtg gccagggtgc ggccgtcggg gctgaaggcg agggtgtcca ccggcttgtc
    23101 gtgggcggtc agcagctccg gttccccggc ctcgccgccg gctgtcagac cgtacagccg
    23161 taccttcttg tcggagctcg cggtggccaa ctgccgtccg cccggcgcga aggcgacgga
    23221 catgacgccg tcggcgtagc cggtgagacg gtcgcgggtg agcgggtgcc gcaggtcggt
    23281 gacattccag aggcgcacgg tgcggtcctc gctgccggtg gccagcgtgc gcccgtcggg
    23341 tgcgaaggcg accgacttca tcgcgccggt gtggccggtg aggaccgaca gacgggcggg
    23401 gtggcgccgg ctggtgacgc cccagagggt ggccgtccgg ttccggctcg ccacggcgag
    23461 ggtacggccg tcgggggcga atgccacgga gtccaccgcc ccggtcaacc gcagggcggc
    23521 cagcgggcgc ggactgcgta cgtccgcggt
//
