LOCUS       NZ_AP023440            22196 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces aurantiacus strain JCM 4677 chromosome.
ACCESSION   NZ_AP023440
VERSION     NZ_AP023440.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces aurantiacus
  ORGANISM  Streptomyces aurantiacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 9428393)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014701115.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 05:58:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,211
            CDSs (total)                      :: 8,122
            Genes (coding)                    :: 7,928
            CDSs (with protein)               :: 7,928
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 161 of 194
            Pseudo Genes (internal stop)      :: 17 of 194
            Pseudo Genes (multiple problems)  :: 48 of 194
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:48:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2079774
            Orig. end                         :: 2101970
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023440.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017557
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22196
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22196
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22196
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12196](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12196)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            372..2774
                     /gene="treY"
                     /locus_tag="IGS71_RS08470"
                     /old_locus_tag="GCM10017557_17480"
     CDS             372..2774
                     /EC_number="5.4.99.15"
                     /GO_function="GO:0047470 - (1,4)-alpha-D-glucan
                     1-alpha-D-glucosylmutase activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381296.1"
                     /locus_tag="IGS71_RS08470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17480"
                     /product="malto-oligosyltrehalose synthase"
                     /protein_id="WP_190849855.1"
                     /sec_met_domain="Alpha-amylase (E-value: 5.3e-13, bitscore:
                     48.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPERPEPVAPTVPTATYRLQLQPEFPFGAAEAAVPYLASLGVSH
                     LHLSPVLEAVPGSGHGYDVVDPARVRDELGGEAGLRSLSRTAREHGLGLVVDIVPNHMA
                     MSPRHNRPLWEVLREGPDSPYAPWFDIDWEAQGGRVLLPVLGQPLGAETGALAVDGDVL
                     RYYDHVFPLRAGTEKLPLPALLDAQWYRLAWWRLARTDLNYRRFFSISELIGVRVEDPE
                     VFAATHAKILELLAEGVVDGLRIDHPDGLADPDAYLRLLHEASGGRWTVVEKILADGEP
                     LPAAWPVAGTTGYDALRHVDGVFTDPAGFGELLGQYRRFADPRADRGGDWEATVRRAAY
                     KVVHHELAAEVDRLTREADRLCRTSADAALRDRAPWALRTALRELLVRLEVYRPYASGD
                     AASVLTEQAADEARGAFKVPEEAHTVDLVRDLVLGRVGEGPPYTAFRARFAQTASALRA
                     KSVEDTAFYRYVPLLSATEVGGEPGSPAVAPEVFHAYCARVQRDWPATGTVLSTHDTKR
                     SADVRAAISVLTQAPARWADLLAEVTGATVAEGAGVPDPQVAWAAWQTAVGLGPAAGER
                     LQDALLKHIREAGLATAWTEQDPVYEDAVAAFLKAGPCGAPGQRVAEFRKSLDPYVRAN
                     VLGAALVHLTMPGVPDLYQGTECEYRALVDPDNRRPVSFPPRDPGMLSAEKAALTRAAL
                     RLRRRRPEVFGESAAYEPLPARGQGAAHCLAFTRSGEVITAVTRLSLRLEEEGGWHDTE
                     LPLPAGRWADLLAPGQEFTGHARVETLFGRLPVALLERVGNDATPSD"
     gene            3034..4284
                     /locus_tag="IGS71_RS08475"
                     /old_locus_tag="GCM10017557_17490"
     CDS             3034..4284
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675708.1"
                     /locus_tag="IGS71_RS08475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17490"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_190849856.1"
                     /transl_table=11
                     /translation="MSLVPEPHYPSVSELVRSARALAAHRPDLCALRQVGVSRAGRPLH
                     LLSVGHARRSVLVVAGAHANEPTGGSTLLALAERVLRERLLRDDTSWHFLLCADPDGAS
                     LHVTPAPRTLFDYHLGFFRPAGPEQPEWSPSVLPPDRLPSETLALFRVIDELRPYLQVT
                     LHGTDLGGSWVQLTKDIPGLAEPFTKSAAELNIPVETGASDAAGWPASGPGVHVMPAPG
                     SDLVYPSMPDDARLSTWYRAHLYGGLTAVVEVPMWASDLVDDPAPHPAPAAAMRGLARR
                     LLQDAHQVETFLVAAQPRLPGPDGPLLRATRWALELVPGLAGDWGRPPPPGTTMAHVGS
                     VDAFGRRLPLRAAAMLLRVLRETDDRTAPGLEHLVAEWSEAFAAHFGARWVPLRHQVEH
                     QSRTVVAAARHARDRSR"
     gene            complement(4341..4820)
                     /locus_tag="IGS71_RS08480"
                     /old_locus_tag="GCM10017557_17500"
     CDS             complement(4341..4820)
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142854.1"
                     /locus_tag="IGS71_RS08480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17500"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_190849857.1"
                     /transl_table=11
                     /translation="MTNNQKATTAVRACLLAACALLVAGPVPARAAALPQSPPGDWLYV
                     TVTRGDARTGDPRTGDPRTGDVRSGDTRGALLLCDPPQGHAHAARACEELRAAHGDVGR
                     IPLKETFCPMVYAPLTAAARGEWGGRTITYEETFANACALTARTGAVFALPEEPH"
     misc_feature    4841..4855
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
     gene            complement(4914..5477)
                     /locus_tag="IGS71_RS08485"
                     /old_locus_tag="GCM10017557_17510"
     CDS             complement(4914..5477)
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385491.1"
                     /locus_tag="IGS71_RS08485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17510"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_055507487.1"
                     /transl_table=11
                     /translation="MTSSSEFHTYPAPARPSDAERERTLKALREGAALGRLSHDTFVVR
                     MELAFAARTSDELAALTADLRTEGRWSRLLFGTVEAVSGFTVRLRRAWQSERLPKLLLP
                     RPENRYPLRIGRDPASGLRLSHETVSRVHAELSRQGDLWVLRDLGSTNGTSVNGRRVIS
                     AAVVQVGDQVSFGRMTFRLAADRS"
     misc_feature    5596..5611
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.81"
                     /tool="antismash"
     misc_feature    complement(5599..5614)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.87"
                     /tool="antismash"
     gene            5669..7414
                     /gene="treZ"
                     /locus_tag="IGS71_RS08490"
                     /old_locus_tag="GCM10017557_17520"
     CDS             5669..7414
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431956.1"
                     /locus_tag="IGS71_RS08490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17520"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_190849858.1"
                     /sec_met_domain="Alpha-amylase (E-value: 2.8e-11, bitscore:
                     42.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRMTLHCADTTRALEPDPGRPGWWTGEAEAQDGTR
                     YGFAVDEGPVLPDPRSYRQPDGPDGLSAVVDHERYAWRADWAGRGLPGAVLYELHVGTY
                     TREGTLDAAAERLGHLAELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHELGLGVVLDVVHNHLGPSGNHLPAFGPYFTESHHTPWGSAVNLDAPGSDDVR
                     AFLLGSALSWLRDYRLDGLRLDAVHALYDTRACHFLEELSAAVDALSGELGRPLFLIAE
                     SDLGDPRLITPRKENGLGLHAQWNDDFHHALHTALTGETQGYYADFGRAPLAAVAKTLT
                     AGYFHNGTYSSFRGRRHGRPLDLTRVAGHRLLGYSQTHDQIGNRALGDRLAASLSPGLL
                     ACAAALTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPELAEAVRQGRRREFTPHGWAEE
                     DIPDPQDPATRDRSCLDWSEPQGGVHARVLAWYRDLIALRHGRPDLTDPDLADVKVAYD
                     ESARWLAFRRGDVRVAVNLGTGRAAIPLGTRQARVLAAWEPVEPPGSDGLLSVPGESCV
                     VLLQG"
     gene            complement(7575..8483)
                     /locus_tag="IGS71_RS08495"
                     /old_locus_tag="GCM10017557_17530"
     CDS             complement(7575..8483)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071453.1"
                     /locus_tag="IGS71_RS08495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17530"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_190849859.1"
                     /sec_met_domain="APH (E-value: 7.4e-21, bitscore: 74.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAATPTTDTVRRLVRSLLPDGGGPRITPVAEGGEHFTWFVGAR
                     HVLRLAPDRETARRRRRELRLRDLVRPHIGVAVPVSIAHGEWASGLTYTLDTLIPGDSG
                     EQQDVSAVGEADLAGLLTGLREVPERQAEALGVPRVRPRSLEALRTAAGRAAEQLAAAD
                     EFDPARLQQLTAPAAVQLAPQPGAAFLVHHDLKGEHLVVSGDGRVRGVLDWTDAAVGDP
                     TEDIAGLALAVGAPAAVRAATLAGYGARPCLRGLWLARCDTLTRLADGLRRPDVGPLPL
                     LRAQLARAWEAILLERVTELR"
     gene            complement(8598..9755)
                     /locus_tag="IGS71_RS08500"
                     /old_locus_tag="GCM10017557_17540"
     CDS             complement(8598..9755)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="IGS71_RS08500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17540"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_190849860.1"
                     /transl_table=11
                     /translation="MTGTPAPFTVDDYRARMERAARAAAEAGLAGVLVAPGPDLVWLTG
                     YAPPAATERLTLLVLAAGRDPVLVVPTLEAPDAEKAVGAPALTLRDWTDGKNPYAVTAP
                     LLDASGLAHRLKGDSGAPIGVSDNTWALHLLGLQKELPGTSYVSLTDGLPMLRAVKDAA
                     ELDRLAAAGAAADDTYEEILKVAFAGRRESDVAGDLADLLRRFGHEQVDFTVVGSGPNG
                     ADPHHEAGSRVIEHGDTVVLDFGGLKYGYGSDTSRTVHVGEPTAEEQRVHDIVRAAQQA
                     AFEAVRPGAACQDIDRAARALITEAGYGDRFIHRTGHGIGVTTHEPPYMIEGEEQPLVP
                     GMCFSVEPGIYLPGRFGVRVEDIVTVTEDGGRRLNDTSREMAVVN"
     gene            complement(10001..12196)
                     /gene="cyc2"
                     /locus_tag="IGS71_RS08505"
                     /old_locus_tag="GCM10017557_17550"
     CDS             complement(10001..12196)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481971.1"
                     /locus_tag="IGS71_RS08505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17550"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_190849861.1"
                     /sec_met_domain="T1TS (E-value: 1.6e-80, bitscore: 270.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPYPARLNPHLDEARAHTTEWARGMGMLEGSGIW
                     EQADLDAHDYGLLCAYTHPECDGPALSLITDWYVWVFFFDDHFLETFKRSQDRSGGKAY
                     LDRLPLFMPLDLSTPVPEPRNPVEAGLADLWARTVPSMSMGWRRRFAESTEHLLNESMW
                     ELSNINEGRVANPVEYIEMRRKVGGAPWSAGLVEYATAEVPEQVARSRPLRVLMETFSD
                     GVHLRNDLFSYQREVEEEGELSNGVLVLETFFGCTTQQAADTVNDILSSRLYQFEHTAL
                     TEVPALALEKGLTPADVRAVTQYTQGLQDWQSGGHEWHLRSSRYMNEGALATSPLSGRS
                     GLGGPGTSAADVGALLAAAGAERLRAYTHVPYQKVGPSLLPDFYMPFQVRLNADLAGAR
                     RRVTPWAHSMGLLREGVWDEDKLDAYDLPLCAAGLDPDGTPEALDLSSQWLAWGTYGDD
                     YYPMVFGHRRDLAAAKLCTARLSACMPVEGEEIPPPANAMERGLADLWRRTTASMTTEA
                     RRTMRAAVEVMTESWVWELSNQLQHRIPDPVDYLEMRRATFGSDLTKSLCRLGHGPKVP
                     PEVYRSGPVRSLENAAIDYGMLINDVFSYQKEIEYEGEVHNALLVVQNFFGCDYPAALG
                     VVHDLMTQRMQQFEHVAAHELPVLYEDLGLSDEVREIMQGYVVELQNWMAGILKWHYDC
                     RRYGAADLARRAHGFVPGQLPELPFGPARRTASIAAL"
     gene            complement(12510..13256)
                     /locus_tag="IGS71_RS08510"
                     /old_locus_tag="GCM10017557_17560"
     CDS             complement(12510..13256)
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071445.1"
                     /locus_tag="IGS71_RS08510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17560"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190849862.1"
                     /transl_table=11
                     /translation="MLRLDSLGQWYGDHPVLHDITLTVPDGQLLCVVGPSGCGKSTLLR
                     TVAGLLPVREGTVRVDGAPVTGVPDRLAVVFQDYGRSLFPWLSVRENVALPLRRRGLGR
                     AQRRAEAERMLARVGLRDAGRRHPWQLSGGMQQRVAIARALVCRPSLLLMDEPFGSLDA
                     QTREDLEDLLLEVHRTEGTTIVFVTHDIDESVYVGDRVVVLSAGPGSRVILDLPVELPG
                     EREQIGTRGLAEFVALRAEVGRAVRG"
     misc_feature    complement(13231..13245)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(13266..14894)
                     /gene="mdlC"
                     /locus_tag="IGS71_RS08515"
                     /old_locus_tag="GCM10017557_17570"
     CDS             complement(13266..14894)
                     /EC_number="4.1.1.7"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mdlC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071444.1"
                     /locus_tag="IGS71_RS08515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17570"
                     /product="benzoylformate decarboxylase"
                     /protein_id="WP_190849863.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7e-38, bitscore:
                     128.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-26, bitscore:
                     92.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPQTGPTRAAGTVLDAVVRLCRDTGMTTVFGNPGSTELRMFRDW
                     PDDFTYVLGLQESVAVGMAAGHALGTGRAALVSLHSAGGVGHSLGAVFNAYRDRVPLVV
                     LAGQQSRSLTQLRPFLGADDPVTFPRPYVKSSRQPDRAADVPAVLAEAHRLAMTHPRGP
                     VFVSVPEDDWDQPAAPVEPRVVHGTFTADASVLAALARRLDACERPALVVGPGVDDEHA
                     TAEVRALAERTRAAVWISPLSGRSGFPESHALFQGFLPPAADRLAARLAAYDVVVALGA
                     PLFTYHFHTEGPPLSDGTELFHLDCDPGQAAWLPTGTSIVTTLKPAVAQLAALVGQSDR
                     EPPPPRPAPPPARVPDDGTITPELVFDLVQERLPRDRVLVEEAPSHRDTLHARVRVDAA
                     GGFLTTGSGALGWGLPLAVGRALADRRRVACLIGDGSTLYSVQALWTAARHRVPVSYVL
                     LDNGGYAAVRALGHRIGIAPVPGTAIGGIGFAQVAEGFGCPAAYVEKAAELPVALDRAL
                     GGHADDGPFLLHVRAVDSAFDAGDR"
     gene            complement(14891..15685)
                     /locus_tag="IGS71_RS08520"
                     /old_locus_tag="GCM10017557_17580"
     CDS             complement(14891..15685)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431981.1"
                     /locus_tag="IGS71_RS08520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17580"
                     /product="ABC transporter permease"
                     /protein_id="WP_190849864.1"
                     /transl_table=11
                     /translation="MKRVEAARGALLRWGVLAVAVAAWQLTTRTRDSVYFPPPSEIARH
                     THGLWFSGPPAHAFLTPAATENILPSLARMTAGFALAATAGIALGTALGRSRRAHALCN
                     PVLQFARAVPPPALVPVFVVVLDFGTPMQLTSIVVSAVWPVLINTAEGVRNTDPLRLEV
                     AAVLRLTAPERLWLVLLPSALPRIFAGLRLSLSLSLILMVFSELLPGTANGIGFTLTDA
                     QSRSDLLTVWATLVLLGVLGHVLNTGLLAVEKRLLGGRRRQA"
     gene            complement(15946..16722)
                     /locus_tag="IGS71_RS08525"
                     /old_locus_tag="GCM10017557_17590"
     CDS             complement(15946..16722)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431982.1"
                     /locus_tag="IGS71_RS08525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17590"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_190849865.1"
                     /transl_table=11
                     /translation="MRRRQELLLGALGVLLALGLCEAVGRAGIVRRSYLPPASEVLTRA
                     VELAGDPLFLAGVGATVRAWALGLGLACVIAVPLGLLLGSVPVVDDAVRAIIEFLRPLP
                     SVALIPLVSLLLGSGTETKVALITYASVWPILFNTVYGLGETDPLAKDTLRAFGFGRLS
                     VLLRVELPATAPFIAAGVRISAAVALVLAVATEILAGFGEGLGIFIAQSQLATDGTRDV
                     LAGVVWAGGLGLVINTVLVWGERRLFPWTPEHRGER"
     gene            complement(16733..17755)
                     /locus_tag="IGS71_RS08530"
                     /old_locus_tag="GCM10017557_17600"
     CDS             complement(16733..17755)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058067.1"
                     /locus_tag="IGS71_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17600"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_246596150.1"
                     /transl_table=11
                     /translation="MPTPRGRAGSTGSTGRLIAFATALVLAVAACGGGSDGSHSDDGGG
                     GGGGRGGKGLERSSVTVAALPLTDSAALYLARDRGLFEKEGLDVRIQPVQQSIQALPAL
                     SKGQVDVIASANYVTFLQAHEKGTLDLRILAEGARVAPHMMDVLVPEDSDIRSVADLKG
                     KKVAVNILNNIQSLTLNAVLGQQGAGRPEYRQIAFPQMGVALEKGQVDAVHAVEPFDSA
                     IQKELNARVLVDGGSAPVEAIPISGYVTTGDYAAKNPRTAAAFRRAITEAAELATRDQD
                     AVREELPEYTKVTADQAESIRLPDYPATSDVSQLRRLTALMKEQGLLKKDIDPGTLLVE
                     "
     misc_feature    complement(17845..17863)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.57"
                     /tool="antismash"
     gene            17896..18453
                     /locus_tag="IGS71_RS08535"
                     /old_locus_tag="GCM10017557_17610"
     CDS             17896..18453
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961517.1"
                     /locus_tag="IGS71_RS08535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17610"
                     /product="hypothetical protein"
                     /protein_id="WP_190849866.1"
                     /transl_table=11
                     /translation="MRSALFSRAARLAAVGATAAALTVGLATSASAATATRSVTVSGTT
                     YNLSLTAPDSLTAAGQNVTVSGSGYNTLQGVYVGLCVIPEGVVPGDPSTYTSRPTPCLG
                     GADQSGTTGASHWVSNQGGGTVANSSVYGSGGSFGVSVHVNPNIASGQVCGTDVDCAIV
                     TRADHTASGTRSYDVYLPVTFS"
     gene            18486..19985
                     /locus_tag="IGS71_RS08540"
                     /old_locus_tag="GCM10017557_17620"
     CDS             18486..19985
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS08540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_17620"
                     /product="hypothetical protein"
                     /protein_id="WP_190849867.1"
                     /transl_table=11
                     /translation="MLRPRAAGALVGITAAVLTAVAFGTPAAGAGADDPPGTGAYERAT
                     RLTTVGKPLDLLLHPESGKLYVGSDTVAGTPDGSLAGVYVVDPASASVRSWVKTSPGST
                     GAPAQLPGKRLAGPLPGDGVHYLVGLRGIAAARDGNATGTGGWLTGTTITQAKAGAKAG
                     TVVVVRGTRLEEVAVGGTSVTVERTLTLPATGGPLAVDTAAGQIWVTDNTNGLLRRVGS
                     ADFAPDGKEIALGAGAAVSFLEWDTGRGVLWAGRGTVLEAYDIASGKPVASFDAKPGDT
                     VADVAVDPRSGRAFAVWQDWGNPPEEGDGVGQLSVYDTATFEDLDLGAELPGVNGQLGG
                     SSVAVAPGGDAVFVASPSDASLTVFRAPVPPTPSASPSPSDSTSPPPSGSPSPDPSGGP
                     ADPSPGDTGPGAEPADTGTTVPVDGPAADGNGTGGTGGTGALGGTGSTTGGGSLGTTGD
                     GSLASTGTDVLLPAAAGTAALLAAGTAAVLWRRRTSGRQEA"
     gene            complement(20029..20706)
                     /locus_tag="IGS71_RS08545"
                     /old_locus_tag="GCM10017557_17630"
     CDS             complement(20029..20706)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433207.1"
                     /locus_tag="IGS71_RS08545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_17630"
                     /product="AIM24 family protein"
                     /protein_id="WP_055520166.1"
                     /transl_table=11
                     /translation="MKGDLFSSEYMVQPATAAGMSLQNAKSIRYAVNGEMLARQGAMIS
                     YRGNLQFERKGQGVGGMLKRAVTGEGLPLMAVRGQGEAWFAHEAQNCFIIDIDPGDVFT
                     VNGRNVLCFDASLQYEIKTVKGAGVTGGGLFNSVFTGQGRLGLVCEGSPLVIPVSPQWP
                     VYVDTDAVVGWTANLQTSLHRSQSIGSMIRGGSGEAVQLMLQGEGFVVVRPSEVTPQKA
                     QQH"
     misc_feature    20951..20965
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 tcacgggcgc cagtgggagg tggtggtgga caccgcgagg ccgggcgggc tggagcccgg
       61 cacgggcggg aaggtcaagg cgggggatcg tctggagctg gtggaccgca gcatggtggt
      121 gttacagcgc ccgacgtgaa cgctccgctg ggctgcggtt ggctggcttg ctgtactcgg
      181 tcggctgcgg ctgcgtcgtg gctggtcgcg cagttccccg cgcccctggg ttttaggggc
      241 gcggggaact gcgcaatcct ttggctcggc cgcagcgggc ccgcacccgc aacaccggga
      301 aacgcgtccc gagcggagcg ctggcgtgtc gagggggcac gaaaccgcgc atcgcgggta
      361 cgtaggtttt catgacacct gagcgtcccg aaccggtcgc ccccaccgtg ccgaccgcca
      421 cgtaccggct ccagctgcaa ccggagtttc cgttcggggc ggccgaggcg gctgtgccgt
      481 atctggcctc gctcggggtc tcgcatctgc atctgtcgcc cgtcctggag gccgtgcccg
      541 ggtcggggca cggctacgac gtcgtggacc ccgcgcgcgt gcgggacgaa ctgggcggcg
      601 aggcgggact gcggtccctg tcgcgcaccg cccgcgagca cggcctcggg ctggtggtgg
      661 acatcgtgcc gaaccacatg gcgatgtccc cccggcacaa ccgccccctg tgggaggtac
      721 tgcgcgaggg ccccgactcg ccgtacgcgc cctggttcga catcgactgg gaggcccagg
      781 gcgggcgggt gctgctgccg gtactcgggc agccgctggg cgcggagacg ggcgccctgg
      841 cggtcgacgg ggacgtcctg cggtactacg accacgtatt cccgctgcgg gccggcaccg
      901 agaagctgcc gctgcccgcg ctgctcgacg cgcagtggta ccggctcgcg tggtggcggc
      961 tggcccgcac cgacctcaac taccggcggt tcttcagcat ctcggagctc atcggggtgc
     1021 gcgtcgagga ccccgaggtg ttcgcggcca cccacgccaa gatcctggag ctgctggccg
     1081 agggggtggt cgacgggctg cggatcgacc acccggacgg cctcgccgac ccggacgcgt
     1141 acctgcgcct cctgcacgag gcgagcggcg ggcgctggac ggtggtggag aagatcctcg
     1201 cggacggcga gccgctgccc gccgcctggc cggtcgcggg caccaccggc tacgacgcgc
     1261 tgcggcacgt ggacggcgtt ttcaccgacc ctgccggttt cggggaactt ctcgggcagt
     1321 accggcggtt cgcggacccc cgggccgacc gcgggggcga ctgggaggcg accgtgcggc
     1381 gggccgcgta caaggtggtc caccacgaac tggccgccga ggtcgaccgg ctcacccgcg
     1441 aggcggaccg gctgtgccgc acgtcggcgg acgcggcgct gcgcgaccgc gccccgtggg
     1501 ccctgcgcac cgcgctgcgg gaactcctcg tccgtctgga ggtctaccgc ccgtacgcct
     1561 ccggggacgc cgcgtcggtc ctcaccgagc aggccgcgga cgaggccaga ggggccttca
     1621 aggtgcccga ggaggcccac accgtcgacc tcgtacggga cctggtgctg ggccgcgtcg
     1681 gcgaaggccc cccgtacacg gcgttccggg cccggttcgc gcagaccgcg tcggcgctgc
     1741 gggccaagtc cgtggaggac acggcgttct accggtacgt accgctgctg tcggcgaccg
     1801 aggtgggcgg cgagccgggg tcgcccgcgg tcgcgcccga ggtcttccac gcgtactgcg
     1861 cgcgcgtgca gcgcgactgg cccgcgaccg gcaccgtcct gtccacgcac gacacgaagc
     1921 gcagcgccga cgtacgggcc gcgatctccg tgctcaccca ggcccccgcg cggtgggccg
     1981 acctgctcgc ggaggtgacc ggggcgacgg tcgccgaggg cgcgggcgtg ccggacccgc
     2041 aggtggcctg ggcggcgtgg cagaccgccg tcggactcgg ccccgccgcc ggggaacgcc
     2101 tccaggacgc gctcctgaag cacatccgcg aggcgggcct cgccacggcg tggaccgagc
     2161 aggaccccgt gtacgaggac gccgtggcgg cgttcctgaa ggcgggcccg tgcggggcgc
     2221 ccgggcagcg cgtcgccgag ttcaggaagt cgctggaccc gtatgtgcgg gcgaacgtcc
     2281 tcggggccgc cctggtccat ctgacgatgc cgggcgtgcc cgacctgtac cagggcacgg
     2341 agtgcgagta ccgggccctg gtggaccccg acaaccggcg gcccgtgtcc ttccctccgc
     2401 gggacccggg catgctgtcc gccgagaagg ccgcgctcac gagggccgcc ctgcggctgc
     2461 gccgacggcg cccggaggtc ttcggcgagt ccgcggcgta cgagccactg cccgcccggg
     2521 gccagggggc cgcgcactgt ctggcgttca cgcgctccgg cgaggtgatc acggccgtca
     2581 cccggctgtc gctgcgcctg gaggaggagg gcggctggca cgacaccgag ttgccgctgc
     2641 ccgccgggcg atgggccgat ctgctcgccc cgggacagga gttcacgggg cacgcacgcg
     2701 tggagacgct tttcgggcgg ttgcccgtgg cgctgctgga gcgggtggga aacgatgcga
     2761 ccccgagcga ctgaccggca gagccgaggg gcgccgccat cggccgcgcc cctcgacgag
     2821 atcaagatca ggagtcaggt cgcggtcgag gtcgaggtcg acggtggggc cggggacggg
     2881 gacgggcgca aggtcggggc cgagggtgga ccgccgcccc cgtcgccggt cggtgccgac
     2941 gggcgccttc cggaggagcc ccaccacgta cgtgagaggt catcccgcct atggagtacc
     3001 gcggatctcg acgcggggcg aactgcatcg gaaatgagtc ttgtgccgga gccgcactac
     3061 cccagtgtca gcgaactcgt ccgttccgcc cgggccctgg cggcccaccg gccggacctg
     3121 tgcgccctca gacaggtcgg cgtctcgcgc gcgggacgac ccctgcacct gctgtccgtg
     3181 ggccacgccc ggcgctcggt gctggtcgtc gcgggcgccc acgccaacga acccaccggc
     3241 ggctccaccc tgctggccct ggccgaacgg gtcctgcgcg agcggctgtt gcgggacgac
     3301 acctcctggc acttcctgct ctgcgcggac ccggacggcg ccagcctcca tgtgacgccg
     3361 gcgccgcgca cgctgttcga ctaccacctc ggcttcttcc gccccgcagg tcccgagcag
     3421 cccgagtggt cgccctccgt gctgccgccc gaccggctgc cgtccgagac actcgccctc
     3481 ttccgggtca tcgacgagct gcgcccctac ctccaggtga cgctccacgg gaccgacctg
     3541 ggcggcagct gggtgcagct gacgaaggac atcccgggcc tcgccgagcc gttcaccaag
     3601 tccgcggccg aactgaacat cccggtcgag acgggcgcct cggacgccgc cggctggccg
     3661 gcctcgggac ccggggtgca tgtgatgccc gcgcccggct cggacctggt gtacccgagc
     3721 atgccggacg acgcccggct gagcacctgg taccgggccc acctgtacgg cggcctgacc
     3781 gcggtcgtcg aggtgccgat gtgggcgagc gacctggtgg acgatcccgc gccgcatccg
     3841 gcgccggcgg cggcgatgcg cggcctggcc cgtcggctcc tccaggacgc gcaccaggtc
     3901 gagaccttcc tcgtcgcggc gcagccacgg ctgcccgggc ccgacgggcc gctgctgcgc
     3961 gccaccaggt gggcgctcga actggtgccc gggctggccg gcgactgggg ccggccgccg
     4021 cccccgggca ccacgatggc gcacgtgggc agcgtcgacg cgttcggccg ccggctcccg
     4081 ctgcgggccg cggcgatgct cctgcgggtc ctgcgggaga ccgacgaccg gaccgcgccc
     4141 ggccttgagc acctcgtcgc ggagtggagc gaggccttcg ccgcacactt cggggcgcgc
     4201 tgggtgcccc tgcgccacca ggtcgagcac cagagccgca cggtggtggc cgcggcgcgg
     4261 cacgcccggg accggtcgag gtaggccgtc cggtcggtgc gcccggcccc gtcgaccccc
     4321 gtcggccccc gtcgacgcgg tcagtgcggt tcctcgggca gcgcgaacac cgcccccgtc
     4381 cgcgcggtca gcgcacaggc gttggcgaac gtctcctcgt acgtgatcgt gcgtccgccc
     4441 cactcgccgc gcgcggcggc ggtcagcggc gcgtagacca tcgggcagaa ggtctccttg
     4501 agcgggatcc ggccgacgtc gccgtgcgcg gcacggagtt cctcgcacgc gcgtgcggcg
     4561 tgcgcgtgcc cctggggcgg gtcgcagagc aggagggcgc cgcgggtgtc gccggagcgg
     4621 acgtcaccgg tacgggggtc accggtacgg gggtcaccgg tacgggcgtc gccgcgggtg
     4681 accgtcacat agagccagtc gcccgggggc gactgcggga gcgccgccgc ccgggcaggc
     4741 accggtcccg ccacgaggag tgcgcaggcg gccagcagac aggcccgtac cgccgtggtc
     4801 gctttctggt tgttcgtcat tgcctgtgca tcggcacacg gggccctccg gcccaccccg
     4861 actcactcga acggcacttc ggcccccggc tgaggcgtgc tcctggcgtg tgctcaggac
     4921 ctgtccgccg cgaggcggaa cgtcatccgg ccgaagctga cctggtcacc gacctggacg
     4981 acggcggcgc tgatcacccg ccgtccgttc acggaggtgc cgttggtcga gccgaggtcg
     5041 cgcagcaccc acaggtcgcc ctggcggctg agttcggcgt gcacccggga caccgtctcg
     5101 tggctgagcc gcagcccgct ggccgggtcg cggcctatgc gcagcgggta ccggttctcg
     5161 ggccggggca gcagcagctt ggggagccgc tcggactgcc aggccctgcg cagccgcacg
     5221 gtgaacccgg agaccgcctc gaccgtgccg aacagcagcc gggaccagcg gccctcggtg
     5281 cgcagatcgg cggtgagcgc ggcgagttcg tccgaggtac gggcggcgaa cgcgagttcc
     5341 atccgcacga cgaacgtgtc gtgcgagagc ctccccaggg cggcaccctc ccgcaacgcc
     5401 ttcagcgtcc tctcccgctc ggcgtccgag ggccgcgcgg gagcgggata ggtgtggaac
     5461 tcggaggacg acgtcacgca gccgattgtc tggcagcacg gccggagtgt ccaggaaaca
     5521 cagcacttca gaggcgttcg tccggtgggc ccggccggat tcgggcgttt gtggccgtcc
     5581 gatcaggagg atccgaaggt gaattgatct cgtttgacgc accatgggac cggcaaggtc
     5641 acggtggaca gacgagggag aaccgtccgt gcagttcgag gtgtgggcac cacaggccga
     5701 ccgcatgacg ctccactgcg cggacaccac gcgcgcgttg gagcccgatc ccgggcgccc
     5761 ggggtggtgg acgggagagg ccgaggcgca ggacggcacg cggtacgggt tcgcggtgga
     5821 cgaaggtccc gtcctgccgg acccgcgctc gtaccggcag ccggacggtc ctgacggcct
     5881 gagcgcggtc gtcgaccacg agcggtacgc gtggcgcgcc gactgggcgg gacgcgggct
     5941 gccgggcgcc gtgctgtacg agctgcacgt gggcacgtac acccgcgagg gcacccttga
     6001 cgcggccgcc gagcggctcg ggcatctggc ggaactgggc gttacccacg tcgagttgat
     6061 gccgctgtgc ccgttcccgg ggcggcacgg atgggggtac gagggggtgt cgctgtgggc
     6121 cgtgcacgag ccgtacggcg gccccgaggc cctgaagcgc ttcgtcgacc gggcgcacga
     6181 gctcgggctc ggcgtcgtcc tggacgtcgt gcacaaccac ctgggtcctt ccggcaacca
     6241 cctgcccgcc ttcgggccgt acttcaccga gtcccaccac actccctggg gctcggccgt
     6301 gaacctggac gcgcccggtt cggacgacgt gcgcgcgttc ctgctcggca gcgcgctctc
     6361 ctggctgcgc gactaccggc tcgacgggct gcgcctggac gcggtgcacg cgctgtacga
     6421 cacgcgcgcg tgccacttcc tggaggagct gtcggccgcc gtggacgcgc tctccggcga
     6481 gctgggccgg ccgctgttcc tgatcgccga gtcggacctg ggcgacccgc ggctgatcac
     6541 gccccgcaag gagaacgggc tcggtcttca cgcgcagtgg aacgacgact tccatcacgc
     6601 gctgcacacc gcgctgaccg gtgagacgca gggctactac gcggacttcg gccgcgcccc
     6661 gctcgcggcg gtggcgaaga cgctgacggc gggctacttc cacaacggca cgtactccag
     6721 tttccggggc cggcggcacg ggcgcccgct ggatctcacg cgggtcgccg ggcaccgcct
     6781 gctcggctac tcgcagaccc acgaccagat cggcaaccgc gccctgggcg accggctcgc
     6841 ggcctccctc tcccccggcc tgctggcctg cgcggccgcg ctgacgctga cggcgccgtt
     6901 cacgccgatg ctgttcatgg gcgaggagtg ggcggcgggc acgccctggc agttcttcac
     6961 ggaccacacc gatcccgagc tcgccgaggc cgtacgccag ggcaggcggc gggagttcac
     7021 cccgcacggg tgggccgagg aggacatccc ggacccgcag gaccccgcca cccgcgaccg
     7081 gtcctgtctc gactggtccg agccacaggg aggggtccac gcacgcgtgc tcgcctggta
     7141 ccgcgacctc atcgcgttgc ggcacggccg gcccgacctc accgaccccg atctcgcgga
     7201 cgtcaaggtc gcgtacgacg agagcgcccg ctggctcgcc ttccgccgtg gcgatgtccg
     7261 ggtggcggtg aacctcggca cggggcgcgc ggcgattccg ctgggtacgc ggcaggcgcg
     7321 tgtgctggcc gcgtgggagc cggtcgaacc tcccggctcg gatgggttgc tgagtgtgcc
     7381 gggcgagtct tgtgtggtgc tcctgcaggg gtgacggggc ggtgggctgg ggtgcggagt
     7441 tgtccgcggg cccggtgggg gctgagcgcg cagttccccg cgcccctgaa aaacaggggc
     7501 gcggggaacg gcgcagtctt ttaggggcgc ggggaactgc gcgaccagcc cccaccgggc
     7561 ccgcaggcga ctcctcaccg aagttctgtt acccgttcaa gcaggatcgc ctcccaggcg
     7621 cgggccagtt gggcgcgcag cagcggcaga gggccgacat cgggccggcg gagaccgtcc
     7681 gcgagccggg tcagcgtgtc gcagcgggcg agccacaggc cgcgcagaca gggccgggcc
     7741 ccgtaaccgg cgagcgtggc cgcgcgcacc gccgcgggcg cgccgacggc cagggccagg
     7801 cccgcgatgt cctcggtggg gtcgccgacc gcggcgtcgg tccagtcgag gacaccccgg
     7861 acccgtccgt cgccgctgac cacgaggtgc tcacccttga ggtcgtggtg gacgaggaag
     7921 gccgcgcccg gctgcggggc gagctggacg gcggcgggcg cggtgagctg ctggagccgg
     7981 gcggggtcga actcgtcggc ggcggcgagc tgttcggcgg cgcgcccggc ggcggtccgg
     8041 agcgcttcga gggaccgggg cctgacgcgg ggcacgccga gtgcctcggc ctggcgctcc
     8101 ggcacctcgc gcagtccggt gagcagtccc gccaggtcgg cctcgccgac ggcggagacg
     8161 tcctgctgct cgccggagtc gccggggatc agtgtgtcga gcgtgtacgt cagcccgctc
     8221 gcccattcgc cgtgggcgat gctcaccggg acggcgacgc cgatgtgggg gcgtaccagg
     8281 tcgcgcagcc gcagttcgcg gcgccggcgc cgggccgtct cgcggtccgg ggcgagccgc
     8341 agcacatggc gtgcgcccac gaaccaggtg aagtgctcgc cgccctcggc tacgggcgtg
     8401 atccggggcc cgccgccgtc cgggaggagg gagcggacga ggcgtcgcac ggtgtccgtg
     8461 gtgggtgtcg ctgcctgggt catggtcgcg ccgtccgccg tggggaggtc cggggtgcgg
     8521 aatctgccgg aagtggagtg gagtggagtg gagtgaactg gagtggaagg ggacggaaat
     8581 aggacggagt ggagtggtca gttcacgacg gccatctccc gggaggtgtc gttgagccgg
     8641 cgtccgccgt cctcggtgac cgtcacgatg tcctcgacgc gtaccccgaa gcggcccggc
     8701 agatagatgc cgggctccac ggagaagcac atcccgggca cgagcggctg ttcctcaccc
     8761 tcgatcatgt acggcggttc gtgggtggtg acgccgatgc cgtgcccggt gcggtggatg
     8821 aagcggtcgc cgtatccggc ctcggtgatg agggcgcggg cggcccggtc gatgtcctgg
     8881 caggcggcac cgggccgcac ggcctcgaac gcggcctgct gggcggcgcg gacgatgtcg
     8941 tggacccgct gctcctcggc ggtcggctcg ccgacgtgca ccgtgcggga ggtgtcggag
     9001 ccgtagccgt acttcaggcc gccgaagtcg aggacgaccg tgtcgccgtg ctcgatgacg
     9061 cgcgagcccg cctcatggtg cgggtcggcg ccgttcgggc ccgatccgac gaccgtgaag
     9121 tccacctgtt cgtgcccgaa ccgccgcagg agatcggcga ggtcaccggc gacgtccgac
     9181 tcacgccggc ccgcgaaggc gaccttcagg atctcctcgt acgtgtcgtc ggcggcggcg
     9241 cccgcggctg ccagccggtc cagttcggcg gcgtccttga ccgcccggag catcggcagc
     9301 ccgtcggtga gggagacgta cgaggtgccg ggcagctcct tctggaggcc cagcaggtgc
     9361 agcgcccagg tgttgtcact gacgccgatg ggggcgccgc tgtcgccctt gaggcggtgg
     9421 gcgaggccgg aggcgtcgag cagcggggcc gtgacggcgt acgggttctt gccgtcggtc
     9481 cagtcgcgga gggtcagcgc gggcgcgccc accgccttct cggcgtccgg ggcctccagg
     9541 gtgggcacga cgagcacggg gtcccgtccg gcggcgagca ccagcagggt gagccgctcg
     9601 gtggccgcgg gcggcgcgta gccggtgagc catacgaggt cgggtccggg cgcgacgagc
     9661 acaccggcga gccccgcctc ggcggcggcc cgtgcggcgc gctccatgcg tgcccggtag
     9721 tcgtcgacgg tgaagggcgc gggcgtgccg gtcatgatcc ggatcctccg tggggcggta
     9781 ggggctacgg tcagcatcct gcccggacag cggaggcgac gcgagccggt aagccctact
     9841 ttcggaaccg gaacccggac cggaaccggt gtcggtatcg gtgtcggtgt cggtgtcgga
     9901 aggggagcgc gcgggcggcg ggccgcgccg gatgtgcggc ccgccgtcgc ccgcgctccc
     9961 ggcccggtgc cgggttgccg ggttgccggt cggtcctggt tcagagggcc gcgatcgagg
    10021 ctgtgcgccg ggcagggccg aacggcagtt ccgggagctg ccccggtacg aagccgtggg
    10081 cgcggcgggc caggtcggcg gctccgtaac ggcggcagtc gtagtgccac ttcaggatgc
    10141 cggccatcca gttctgcagc tccacgacat agccctgcat gatctcgcgg acctcgtcgg
    10201 agaggccgag gtcctcgtac aggacgggca gttcatgggc cgcgacatgc tcgaactgct
    10261 gcatgcgctg ggtcatgagg tcgtggacga cgccgagcgc cgccgggtag tcgcagccga
    10321 agaagttctg cacgaccagg agcgcgttgt gcacctcgcc ctcgtactcg atctccttct
    10381 ggtacgagaa gacgtcgttg atgagcatcc cgtagtcgat cgcggcgttc tccagcgacc
    10441 ggacgggacc gctgcggtag acctccggtg gcaccttcgg gccgtggccc aggcggcaca
    10501 ggctcttggt gaggtcggag ccgaaggtgg cgcggcgcat ctccaggtag tcgacggggt
    10561 cggggatgcg gtgctgcagc tggttggaca gctcccacac ccagctctcc gtcatgacct
    10621 ccaccgcggc ccgcatggtg cggcgcgcct ccgtggtcat cgaggccgtc gtgcgccgcc
    10681 agaggtcggc gaggccgcgc tccatcgcgt tggccggggg cgggatctcc tcgccctcga
    10741 cgggcataca ggcggacagc cgtgcggtgc acagcttcgc ggcggccaga tcccggcggt
    10801 gcccgaacac catcgggtag tagtcgtcgc cgtacgtccc ccaggcgagc cactgcgagc
    10861 tgaggtccag ggcctcgggt gtgccgtccg ggtcgaggcc cgccgcgcac agcggcaggt
    10921 cgtaggcgtc gagcttgtcc tcgtcccaga cgccctcccg caggaggccc atgctgtgag
    10981 cccacggggt gacgcgccgc cgggccccgg ccaggtcggc gttgagccgg acctggaacg
    11041 gcatgtagaa gtcggggagc agggagggac cgaccttctg gtacggcaca tgcgtgtagg
    11101 cgcgcagccg ctcggcgccg gccgcggcga gcagggcccc gacgtcggcg gcggaggtgc
    11161 cgggcccgcc gagaccgctg cggccgctca ggggggaggt cgccagggcg ccctcgttca
    11221 tgtaccggct cgaccgcagg tgccactcgt ggccgccgga ctgccagtcc tgcaatccct
    11281 gggtgtactg ggtgacggca cggacatcag ccggggtgag gcccttctcc agggccagcg
    11341 cgggcacctc ggtgagcgcc gtgtgctcga actggtacag ccgcgaggag aggatgtcgt
    11401 tgacggtgtc ggcggcctgc tgggtcgtgc agccgaagaa cgtctccagg acgagtactc
    11461 cgttgctgag ctcgccctcc tcctcgacct cccgctggta cgagaagagg tcattgcgca
    11521 ggtggacccc gtcggagaag gtctccatca gcacgcgcag cggccgggag cgggcgacct
    11581 gctcggggac ctccgcggtc gcgtactcca cgagcccggc cgaccagggg gcgccgccca
    11641 ccttgcggcg catctcgatg tactcgacgg ggttcgcgac ccgcccttcg ttgatgttgg
    11701 acagctccca catcgactcg ttgagcagat gctcggtcga ctcggcgaac cgcctgcgcc
    11761 atcccatgga catcgagggg accgtgcgcg cccacaggtc ggcgagcccg gcctcgaccg
    11821 ggttccgcgg ttcgggcacg ggggtcgaga ggtcgagcgg catgaagagc gggaggcggt
    11881 ccaggtaggc cttgccgccg gagcggtcct ggctgcgttt gaaggtttcc aggaagtggt
    11941 cgtcgaagaa gaagacccac acgtaccagt cggtgatgag cgagagggcg ggaccgtcgc
    12001 attcgggatg cgtgtacgcg cacagcagtc cgtagtcgtg cgcgtcgagg tcggcctgct
    12061 cccagatgcc ggagccctcc agcatgccca ttccgcgcgc ccactcggtg gtgtgggcgc
    12121 gggcctcgtc gagatgcggg ttcagccgcg cgggatacgg catgtagaag tgtgggagtt
    12181 cgaacggctg cgtcatggcc cggcactacc cgggggtgtg ggcgggcatc cgtgtggcgg
    12241 gcaatgatcg caccatcgcg tgaacggtcg aatgaccgcg cccgcggcgg ggaagggtgt
    12301 gctttcgccc ccgccgcccc tacccttccc gtcactactg ggggctgccg cccccagacc
    12361 cccgcaatcg cgctgcgcgc tcgtcctcaa acgccggacg ggctgaattt ttcagcccgt
    12421 ccggcgtttg aggaccgggg gttcgggggc ggagcccccg aggcagggac gggaagggta
    12481 ggggcggcgg gggcgaaaac cgcccagcct cacccccgca ccgcccgccc cacctccgcc
    12541 cgcaacgcca cgaactccgc caacccccgc gtcccgatct gctcccgctc cccgggaagc
    12601 tcgaccggca ggtcgaggat cacgcgtgag ccggggccgg ccgagaggac gaccacccgg
    12661 tcccccacgt acacgctctc gtcgatgtcg tgggtgacga acacgatcgt cgtgccctcg
    12721 gtccggtgga cctccagcag gaggtcctcc aggtcctcgc gggtctgggc gtcgagggag
    12781 ccgaagggct cgtccatgag cagcagggac gggcggcaca ccagggcacg ggctatggcg
    12841 acacgttgct gcataccgcc ggagagctgc cagggatgcc ggcgccccgc gtcgcgaaga
    12901 cccacccggg ccagcatccg ctcggcctcc gcccgccgct gcgcgcgccc gagtccccgc
    12961 cgccgcaacg gaagcgcgac gttctcgcgg accgagagcc aggggaagag ggaccgcccg
    13021 tagtcctgga agacgacggc cagccggtcc ggcacaccgg tgaccggtgc cccgtcgact
    13081 cggacggtcc cctcccgtac gggcagcagt cccgcgacgg tccgcagcag cgtcgacttg
    13141 ccgcagccgg acggcccgac gacacacagg agctggccgt cgggcacggt gagcgtgatg
    13201 tcgtgcagga cggggtggtc gccgtaccac tggccgagcg agtcgaggcg cagcatgcgg
    13261 gccgctcacc tgtccccggc gtcgaacgcg ctgtcgaccg cccggacgtg cagcaggaag
    13321 ggcccgtcgt cggcgtggcc gccgagggcc cggtcgagcg cgacggggag ttcggcggcc
    13381 ttctccacgt acgcggccgg gcagccgaag ccctccgcca cctgtgcgaa gccgatgccc
    13441 ccgatggccg tgccgggcac gggcgcgatg ccgatgcggt ggccgagggc gcggacggcc
    13501 gcgtatccgc cgttgtcgag gaggacgtac gagacgggca cgcggtgccg ggcggcggtc
    13561 cacagggcct gtacggagta cagcgtcgag ccgtcgccga tcaggcacgc cacccgccgc
    13621 cggtcggcca gcgcgcgccc gacggcgagc ggcagccccc agccgagcgc cccgctgccc
    13681 gtggtgagga acccgcccgc cgcgtcgacg cgcacgcgcg cgtggagcgt gtcgcggtgg
    13741 ctgggtgcct cctccacgag gacgcggtcg cgcggcagcc gttcctggac gaggtcgaac
    13801 accagctccg gcgtgatcgt gccgtcgtcg ggaacgcggg cgggcggtgg agccgggcgg
    13861 ggaggcggtg gctcgcggtc cgactgcccg accagtgcgg cgagttgcgc gacggccggt
    13921 ttcagggtcg tgacgatgct cgtgcccgtc ggcagccatg ccgcctgtcc cggatcgcag
    13981 tcgaggtgga agagctcggt gccgtcggac agcggcgggc cctccgtgtg gaagtggtac
    14041 gtgaacaggg gcgcccccag ggccaccacc acgtcgtacg ccgccaggcg ggccgccagc
    14101 cggtcggccg cgggcggcag gaacccctgg aagagcgcgt gcgactccgg gaagccggag
    14161 cgtcctgaca gcgggctgat ccagacggcg gcgcgggtgc gttcggcgag ggcgcggacc
    14221 tcggcggtcg cgtgttcgtc gtcgactccg ggcccgacga ccagcgcggg ccgttcgcac
    14281 gcgtcgaggc gccgcgcgag ggcggccagg acgctcgcgt cggcggtgaa cgtgccgtgc
    14341 accacgcgcg gttcgacggg cgcggccggc tggtcccagt cgtcctcggg gacggagacg
    14401 aacacgggac cgcgcgggtg cgtcatggcg aggcggtggg cctccgcgag cacggccggt
    14461 acgtcggccg cgcggtccgg ctggcggctc gacttcacgt acgggcgcgg gaacgtgacc
    14521 gggtcgtccg ctccgaggaa cggcctgagc tgggtcagcg agcgggactg ctggccggcc
    14581 agcacgacga gggggacgcg gtcgcggtac gcgttgaaga cggcgcccag ggagtggccc
    14641 acgccgcccg ccgagtgaag gctgacgaga gccgcccggc cggtgcccag tgcgtgtcct
    14701 gcggccatgc ccacggccac ggactcctgt agtcccaaca cataggtgaa gtcgtcgggc
    14761 cagtcgcgga acatccgcag ttccgtggag ccggggttgc cgaagacggt ggtcatgccg
    14821 gtgtcgcggc acagccggac gacggcgtcc aggacggttc ccgccgcacg ggtcggtccc
    14881 gtctgcggct tcatgcctgc ctccttcttc cgcccagcag tcgcttctcg accgccagca
    14941 ggccggtgtt gagtacgtgt cccagtacgc cgagcagcac cagcgtggcc cacacggtga
    15001 gcaggtccga gcgcgactgg gcgtcggtga gggtgaagcc gatgccgttg gccgtgccgg
    15061 gcagcaactc cgagaagacc atgaggatga gggagagcga aaggctcagg cgcaggcccg
    15121 cgaagatacg gggcagcgcc gagggcagga ggacgagcca cagccgttcc ggcgccgtca
    15181 ggcgcagtac ggcggccact tcgaggcgga gggggtcggt gttgcggaca ccttccgccg
    15241 tgttgatcag taccggccag acggcgctga cgacgatcga cgtgagctgc atcggggtgc
    15301 cgaagtcgag gacgacgacg aagacgggga ccagggcggg gggtgggacg gcgcgggcga
    15361 actgcaggac cgggttgcac agggcgtggg cacggcggga gcggcccagg gccgtaccga
    15421 gagcgatacc ggcggtcgcg gcgagggcga agccggcggt catgcgggcg aggctgggga
    15481 ggatgttctc ggtggcggcc ggggtgagga aggcgtgtgc gggcgggccc gagaaccaca
    15541 ggccgtgggt gtggcgggcg atttctgagg gtggcgggaa atagacgctg tcgcgtgtgc
    15601 gggtggtcag ttgccatgcg gcaactgcca cggcgagcac gccccagcgc agcagggcgc
    15661 cacgcgctgc ctcaacccgt ttcattcgcc cccgccgccc ctacccgccc ccaagctctc
    15721 ggcttcgctc gaccaggggg gacccccacc gtcaagtctc gtcaagtctc gggggctccg
    15781 cccccgaacc cccgctcctc aaacgccgga ggggctgaca taccagcccg tccggcgttt
    15841 gaggacgagg ccgttcaggc cgatgcgggg gtctgggggc ggcagccccc agaaacgacg
    15901 ggaagggtag gggcggcggg ggcgaaaacc gaccgcccac ccccctcacc gttccccccg
    15961 atgttccggt gtccaaggga acagcctccg ttcgccccac accagcaccg tgttgatgac
    16021 gagccccagg cccccggccc agaccacccc ggccagcacg tcccgtgtgc cgtccgtcgc
    16081 cagttgcgac tgggcgatga agatgccgag cccctccccg aagcccgcca ggatctcggt
    16141 ggcgacggcg aggacgaggg cgaccgccgc ggagatgcgc acgcccgccg cgatgaaggg
    16201 cgcggtggcg gggagttcga cccgcaggag gaccgacagg cggccgaagc cgaaggcacg
    16261 cagcgtgtcc ttggccagcg ggtcggtctc gccgaggccg tagacggtgt tgaagaggat
    16321 cggccagacg gaggcgtacg tgatgagcgc gaccttcgtc tccgtaccgg aacccagcag
    16381 cagggacacc agggggatca gcgcgacgga cggcaggggg cgcaggaact cgatgatcgc
    16441 acgcacggcg tcgtcgacga cgggcacgct gccgaggagc aggcccagcg gcacggcgat
    16501 cacgcaggcg agacccaggc cgagggccca ggcgcgcacg gtggctccga ctcccgccag
    16561 gaagagcggg tcgcctgcca gctccacggc ccgcgtcagg acttcggagg ccggcggcag
    16621 gtagctgcgc cgcacgattc ccgcccggcc gaccgcctcg cacaggccga gggcgagcag
    16681 caccccgagc gcaccgagca gcagttcctg tcgacgcctc acccgcttcg cctcactcga
    16741 ccagcagcgt tcccggatcg atgtccttct tcagcaggcc ctgttccttc atgagtgcgg
    16801 tgaggcggcg cagttgggac acgtccgacg tcgccgggta gtccggcagc cggatcgact
    16861 cggcctggtc cgcggtcacc ttggtgtact cgggcagttc ctcgcgtacc gcgtcctggt
    16921 cccgtgtggc gagttccgcc gcctcggtga tcgcccgccg gaacgccgcc gccgttctgg
    16981 ggttcttggc cgcgtagtcg ccggtcgtga cgtatccgct gatcggtatg gcctccacgg
    17041 gagcggagcc gccgtcgacg aggacgcggg cgttcagctc cttctggatg gcgctgtcga
    17101 agggctcgac ggcgtggacc gcgtcgacct gccccttctc cagggcgacc cccatctggg
    17161 ggaaggcgat ctgccggtac tcgggacggc ccgcgccctg ctggccgagg accgcgttca
    17221 gggtcagcga ctggatgttg ttgaggatgt tgacggcgac cttcttgccc ttgaggtcgg
    17281 cgacgctgcg gatgtcggag tcctcgggca cgagtacgtc catcatgtgc ggcgcgacgc
    17341 gggctccctc ggcgagaatg cgcaggtcca gggtgccctt ctcgtgggcc tggaggaagg
    17401 tgacgtagtt cgcgctcgcg atgacgtcga cctggccctt cgacagggcg ggcagcgcct
    17461 ggatgctctg ctggacgggc tggatgcgga cgtccaggcc ctccttctcg aacagccccc
    17521 ggtcccgcgc gaggtagagg gcggcgctgt ccgtcagggg cagcgcggcg accgtgacgc
    17581 tcgacctctc cagccctttg ccgcccctgc ctccgcctcc gcccccgccg tcgtcggaat
    17641 gcgagccgtc ggacccgccg ccgcaggcgg cgacggccag caccagggct gtcgcgaagg
    17701 cgatcagtct tcccgtgctt cccgtgcttc ccgcacggcc tcggggcgtc ggcatgcgcg
    17761 catgatcctg cccgtattgg cgtgatcaca acatcacttc gcgccgttcc cgagtgaccg
    17821 ggttgacgat ccttgagctg caacttaggt ttgccttacc taagtggttc tcgccttcga
    17881 aagggccaac tacccatgag atccgccctg ttctcccgtg ccgcccgtct cgccgccgtc
    17941 ggagccaccg ccgccgcgct gacggtcgga ctcgccacct cggcctcggc cgccaccgcc
    18001 acccggtcgg tgaccgtgag cggcacgacg tacaacctgt cgctgacggc ccccgacagc
    18061 ctgacggccg ccggccagaa cgtcaccgtc tccggcagcg gctacaacac gctccagggt
    18121 gtctacgtcg gcctgtgtgt gatccccgag ggcgtcgtgc cgggagaccc gtcgacgtac
    18181 acctcccggc cgaccccctg cctgggcggc gcggaccagt cgggcacgac gggcgcctcg
    18241 cactgggtgt cgaaccaggg cggcggcacg gtcgcgaaca gctccgtcta cggctccggc
    18301 ggctccttcg gggtcagcgt gcacgtgaac ccgaacatcg cctccggcca ggtctgcggc
    18361 acggacgtcg actgcgccat cgtgacgcgc gccgaccaca cggcgagcgg cacccgctcg
    18421 tacgacgtct accttccggt caccttctcg tgaccgcgcc cttcagaacc cgggggcgga
    18481 gcgatgtgct ccgcccccgg gcggccggcg ccctggtggg catcacggcg gcggtcctca
    18541 ccgccgtcgc gttcggcacg cccgccgccg gcgccggcgc cgacgacccg cccggcaccg
    18601 gcgcgtacga gcgtgcgacc cgcctcacga ccgtcggcaa accgctcgac ctgctgctgc
    18661 accccgagtc ggggaagctg tacgtcgggt ccgacaccgt cgccggtacg ccggacggca
    18721 gcctggccgg cgtctacgtc gtcgacccgg cgtccgcgag cgtacggagc tgggtgaaga
    18781 cgtcacccgg cagcacgggc gcgcccgccc agctcccggg caaacggctc gccgggccac
    18841 tgcccggcga cggggtgcac tacctggtcg ggctgcgcgg gatcgcggcc gcccgggacg
    18901 gcaacgcgac cgggaccggg ggctggctca ccggcacgac gatcacgcag gccaaggcgg
    18961 gcgcgaaagc cggcaccgtc gtggtcgtcc gcgggacgag actggaggag gtcgccgtcg
    19021 gcgggacgtc ggtgaccgtc gaacgtaccc tcacgctccc ggccaccggc ggtccgctcg
    19081 ccgtggacac cgccgccggg cagatctggg tcaccgacaa caccaacggg ctgctgcgca
    19141 gggtcggttc ggccgacttc gcgccggacg gcaaggagat cgccctcggc gccggggccg
    19201 cggtgtcctt cctggagtgg gacaccgggc gcggggtgct gtgggcggga cgcggcaccg
    19261 tcctggaggc gtacgacatc gcctccggca agccggtcgc ctcgttcgac gcgaaaccgg
    19321 gcgacaccgt cgcggacgtc gccgtggacc cgcggtcggg gcgggcgttc gcggtgtggc
    19381 aggactgggg caacccgccg gaggaggggg acggcgtggg acagctctcg gtctacgaca
    19441 cggcgacgtt cgaagacctc gacctgggcg ccgaactgcc cggtgtcaat ggccagttgg
    19501 gcggctcgtc cgtcgcggtg gcaccgggcg gcgacgcggt gttcgtcgcg agcccctccg
    19561 atgcctcgct caccgtgttc agggcgccgg tgccgccgac gccctccgcc tcgccgtcac
    19621 cgtcggactc gacgtcgccg ccaccgtcgg gctcgccctc gcccgatcct tccggcggac
    19681 cggccgaccc gtcacccggc gatacgggcc cgggtgccga accggccgac acgggcacca
    19741 cggttcccgt cgacggcccg gcggccgacg ggaacggcac gggtggcacg ggcggcacgg
    19801 gtgccctggg tggcacaggg agcacgaccg ggggcggttc gctcggcacc accggtgacg
    19861 ggtcgctcgc ctcgaccggc acggatgtgc tcctgcccgc ggcggcgggc accgcggcgc
    19921 tgctcgccgc cggcaccgcc gcggttctgt ggcgccggcg gacgagcgga cggcaggaag
    19981 cctgaaagac gtgggcgcgg gacgcggcag gcccgacagg agctcgtatc agtgctgttg
    20041 ggccttctgc ggtgtgacct cgctcggccg tacgacgacg aatccctccc cctggagcat
    20101 caactgcacg gcctcgcccg agccgccgcg gatcatcgag ccgatggact gcgaacggtg
    20161 cagcgaggtc tggaggttgg ccgtccagcc gacgacagcg tccgtgtcca cgtacaccgg
    20221 ccactgcggt gagaccggga tgaccagcgg gctgccctcg cagacgaggc cgagcctgcc
    20281 ctgtccggtg aagacgctgt tgaacagccc cccgccggtg acccccgcgc ccttcaccgt
    20341 cttgatctcg tactgcagcg acgcgtcgaa gcacaggacg ttgcggccgt tgacggtgaa
    20401 gacgtcaccc gggtcgatgt cgatgatgaa gcagttctgt gcctcgtgcg cgaaccaggc
    20461 ctccccctgt ccgcgcaccg ccatgagcgg cagcccctcg ccggtgaccg cgcgcttgag
    20521 catgccgccg acgccctggc ccttgcgctc gaactgcagg ttgccgcggt aggagatcat
    20581 cgcgccctgc cgggcgagca tctcgccgtt gacggcgtac ctgatcgact tcgcgttctg
    20641 caggctcatg cccgccgcgg tggccggctg caccatgtac tcactggaaa acagatcacc
    20701 cttcatccgg gcatcctgtc ccgaaggcgt cggttccacc atcccagaac ggaaaaacag
    20761 ccgccgtcac ctcagatgct ttccgctgcc gtcgccggtt ctggttgtgg ttccggttcc
    20821 ggttccggtg tccgggtgtc gtcgtcggcc gcgaggaact gcgtggcggc cagttccgcg
    20881 tacagcgggt cgcccgcgac gagttcgcgg tgggtgccca cggcccgtac ctgcccggcg
    20941 tccatgacga cgatgcggtc ggccatggtg acggtggaca gccggtgggc gacgaccagg
    21001 accgtggtgg tgcgggcgac gtcggtgacc gtgtcgcgca gcacggcctc gttgaccgcg
    21061 tcgagctggc tggtggcctc gtcgagcagc agcagccggg gccgccgcag gagcgcgcgg
    21121 gcgatggcga cgcgctgccg ctcaccgccg gacagcttgg tgccgcggtg gcccacgagc
    21181 gtgtccacgc ccttgggcag ccggtcgacg agggtgtcga gccgggtggt cttgagcgcg
    21241 cggagcagct cgtcctcgtc cgcgtccggg ttgccgagca ggaggttgtc gcggaggctg
    21301 ccggagagca cgggcgcgtc ctgctccacg tagccgatgg ccgaccggag cgtggacacc
    21361 tcccactcgg tgaggtcgcg gccgtccagc gcgatggttc ccccgtcggg gtcgtagaac
    21421 cgctcgatga gcgagaacac ggtggtcttg ccggcgcccg acgggcccac gaaggcggtc
    21481 atgccgcgcg ggggcacggt gaaggtcacg ccgtggtgga cgtacggcag gtcgtcggcg
    21541 taccggaagc ggacgtcctc gaaggcgacc gaggccggtt cggcgcccgg tcctggcagc
    21601 ggcgcgggct cggcggccgg ctcggcgggc agcagccgcg cctcctcgat acgggccagg
    21661 gcggccgatc cggtctggta ctgggcgacc gctccgacga cctgctggat cggcgccatc
    21721 aagtagaaga cgtacagcag gaaggcgacg agtgtgccga tgtcgacggc cccggtcgcg
    21781 acccgtgcgc cgcccacggc gaggacggtg atgaacgcga tctgcatcga gaggccggcc
    21841 gtgttcccgg ccagcgccga ccacttggcg gcccggacgc tctgccgcca ggactcctcg
    21901 gccgccgcgt gcacggcccg ctcctcgcgg tgctcggcgc cggacgcctt gatggtccgc
    21961 agcgcgccca gggtccgctc cagcgaggcg cccatcgccc cgaccgcgtc ctgggcccgc
    22021 ctgctggccc ggttgatgcg cggcacgatc acgccgatca ccgtgcccgc gcacacgacg
    22081 acgcccaggg tgacggccgt cagcaccggg tcgacgaacc ccatcagcgc gagcgtggcc
    22141 accagcgtca gaccgcccgt gccgagaccc accagcgagt cggtggtgac ctcccg
//
