LOCUS       NZ_AP023440            21149 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces aurantiacus strain JCM 4677 chromosome.
ACCESSION   NZ_AP023440
VERSION     NZ_AP023440.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces aurantiacus
  ORGANISM  Streptomyces aurantiacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 9428393)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014701115.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 05:58:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,211
            CDSs (total)                      :: 8,122
            Genes (coding)                    :: 7,928
            CDSs (with protein)               :: 7,928
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 161 of 194
            Pseudo Genes (internal stop)      :: 17 of 194
            Pseudo Genes (multiple problems)  :: 48 of 194
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:48:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1905254
            Orig. end                         :: 1926403
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023440.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017557
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21149
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="12"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21149
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21149
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11149](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11149)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    1408..1422
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    2408..2420
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     misc_feature    complement(2688..2700)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: medium, score: 23.87"
                     /tool="antismash"
     misc_feature    5280..5296
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 24.84"
                     /tool="antismash"
     gene            complement(5665..9303)
                     /locus_tag="IGS71_RS07755"
                     /old_locus_tag="GCM10017557_16020"
     CDS             complement(5665..9303)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082059.1"
                     /locus_tag="IGS71_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16020"
                     /product="indolepyruvate ferredoxin oxidoreductase family
                     protein"
                     /protein_id="WP_246596127.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-08, bitscore:
                     33.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAGVSTQTTQMTQTTPTPTLTLTPTPTPTPTSSGFTLEDRYLQ
                     EEGRVYLTGVQALVRLLFDRIRHDRRAGLDNAAFVSGYEGSPLAGFDLELMRRVPLLTE
                     HGVVHRPGLNEELAATSVMGSQLAGEVGRLRTDGVVGLWYGKAPGLDRATDALRHANLV
                     GTSPRGGALALVGDDPAAKSSSVPCASELALADLAVPIFYPADSQDILDYGLHAVELSR
                     ASGVWASMKIVANVADAAGTAVVHPVWQPPVLPSGAYTHRPDGHLLGAGLAKLEQSLHH
                     VRLPLVQEYLRAGKVNRILNQTPDDRIGIITAGKTHLDVQQALRSLGLDDKGLARLGIR
                     LLKLAVIHPLEPTVVREFAAGLREVIVVEEKRSFVEAAVKDTLYGITGAPSVHGKHGPD
                     GTTLFSAVGELDPESIAAGFARRLADHGFRAPSSSSSSSPTPRPRERVSLPLLARTPYF
                     CSGCPHNSSTKVPDGSLVGAGIGCHTMAVFMEPEQVGHVVGMTQMGGEGAQWFGMAPFL
                     DDDHFVQNIGDGTFMHSGSLAVRAAVASGVNITYKLLYNSAVAMTGGQQPVGALPVDRV
                     AALLLLEGAAKVIITSEAPDRLRKAVLPKGVVVRHRDHLISSQEELAATPGVTVLIHDQ
                     ECAAEKRRKRRRGTVATPTTRVMINERICEGCGDCGAKSNCLSVQPVGTEFGRKTAIDQ
                     SSCNLDFSCLDGDCPSFVTVTPSGRKSGPKTPELAAADLPEPDRRDGQAGQGGQDSFTV
                     RITGIGGTGVVTVAQILATAAVLDGKHVRTLDQTGLAQKGGAVVSDIKITSGVVAQAAK
                     LARSECDLYLACDILVGADPKHLAAADPGRTTAVVSTTEVPTGRMVVDTEVAFPEQGPV
                     KDAIRAASARALYLDARARSEALFGEDRFANVLQLGVAYQSGAMPLPAEAIEEAITLNG
                     TAVQANLQAFRRGRQLVADPAAATAATTASPPSPPAVPGVTTPAVATPAVATPAVAAAV
                     ARIRSLVAAEPGTDLARLLDIRIPDLIQYQNEKYARSYALYVEQVRAREAPATAVTEAV
                     AHHLYKLMAYKDEYEVARLALDETLRQQIAAEFGEGSRFSYRLHPPVLRALGVKRKISL
                     GRWFRPVFRVLRAMRRLRGTPLDLFGYAHVRRVERSLVEDYRRTVARALSAVESDPGLV
                     KELAELPDRVRGYEQIKLRNVTAYRQRQAELLAELGLTPSGTPAGS"
     gene            9461..9931
                     /locus_tag="IGS71_RS07760"
                     /old_locus_tag="GCM10017557_16030"
     CDS             9461..9931
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007503367.1"
                     /locus_tag="IGS71_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16030"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_055517669.1"
                     /transl_table=11
                     /translation="MDDLDTSLLRLLLEEPRAGMREYARVLGVARGTVQARLARLEQSG
                     VIAGYAPQLSAPGMGYPVLAFVHLHLAQGRLDEITAALHAVPEVLEAHSIAGEGDLVCR
                     VAARENAHLEDVIQQLIKLPGVVRTKTEVVLSERVAPRTLPLVLQADDRRRR"
     gene            complement(10001..11149)
                     /locus_tag="IGS71_RS07765"
                     /old_locus_tag="GCM10017557_16040"
     CDS             complement(10001..11149)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="IGS71_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16040"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_190849783.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.4e-43, bitscore:
                     147.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDDRVVVREAASVGHTEGRRGGFSCAEDFRAVEEVLARFLEEQG
                     ALSAEPEVAELVGWVRGSLAGGKQLRPLLCCLGWRAGGGTGPLPPAVARVAASFEMFHT
                     FAVLHDDVMDDAETRRGRPAAQHLVAARHRGHAQAQKLGRDTAILLGDIALGWSYELVG
                     TADIDDHRRRRVGRALATMRTQTVVGQYLDLVGTDTAPAGTVEDVGHGAVEDVGHALRI
                     ARGKTAGYTVGWPLHIGAVLAHADETIIEALTRFGLAVGEAFQLRDDLLNVFGHAPTTG
                     KPSGDDLCHRKHTALLALAWRDADPRQRARLTQLMDRTSLDETALTEARTILTDTGARS
                     HIEDLITTRLDEARQALTETTLPPDITTTLTDLAHHATHRDH"
     gene            11264..11665
                     /locus_tag="IGS71_RS07770"
                     /old_locus_tag="GCM10017557_16050"
     CDS             11264..11665
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016579353.1"
                     /locus_tag="IGS71_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16050"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_190849784.1"
                     /transl_table=11
                     /translation="MSHSHSAGDVFFADCPTRLAIDIITDKWAVVVLFALSRKPCRHGE
                     LVGLIGGISRKVLTQTLRRLQGYGLVDRRAYAEAPPRVEYSLTDLGRTLVEPISVLTDW
                     ARSYGEAIVSFQNANDANEEDPPEGSTTM"
     gene            complement(11712..12602)
                     /locus_tag="IGS71_RS07775"
                     /old_locus_tag="GCM10017557_16060"
     CDS             complement(11712..12602)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004935403.1"
                     /locus_tag="IGS71_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16060"
                     /product="PRC and DUF2382 domain-containing protein"
                     /protein_id="WP_055510905.1"
                     /transl_table=11
                     /translation="MITQEQIPAVLEHPVYDAEGSKIGEASHVFYDDATGRPEWVSIKT
                     GFFGTNESFVPIREAVMVEDHLEVPYPKDKVKEAPNVDVDGGGHLSESEEVRLYEHYGI
                     AWDDAWQQANRPGHGWAHAGTAEAAGTVGAAGAAGTTGAAGTGRATGAAGAMGRDTDMP
                     EDIAVTRSEEHMRVATERYESGRARLRKYVVTEEVQQTVPLRHEEARVVREPITEANRD
                     EAMSGPEFREAEHEVTLHAERAVVQTEAVPMERVRLSTEEVMENETVSGQVRKEQVVID
                     DVAVDDDEERGRPRR"
     gene            12847..13494
                     /locus_tag="IGS71_RS07780"
                     /old_locus_tag="GCM10017557_16070"
     CDS             12847..13494
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157884.1"
                     /locus_tag="IGS71_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16070"
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="WP_055510904.1"
                     /transl_table=11
                     /translation="MPAIPADPTVLHPMPDQPRVVLLKPLVTSPLIEVGEFSYYDDPDD
                     PTAFERRNVLYHYGPEKLVIGKFCALGEGVRFIMNGANHRMDGPSTFPFPIMGASWAEH
                     FDLITGLPGRGDTVVGNDVWFGHRTMIMPGVRIGHGAIIASGSVVVDDVPDYGIVGGNP
                     AGLIRRRYSDTDIARLLAVAWWAWPTQHITEHIRTIMSGSVDDLEAAAPSEQ"
     gene            complement(13538..14308)
                     /locus_tag="IGS71_RS07785"
                     /old_locus_tag="GCM10017557_16080"
     CDS             complement(13538..14308)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385297.1"
                     /locus_tag="IGS71_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16080"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_190849785.1"
                     /transl_table=11
                     /translation="MTREGHLVITPALPVSHDVSGPNHPSQPNHPSQPSGPSRRSRPSR
                     PSDTAASADESITAWALAARTGDPEAVDRFVRALHRDVVRYVAYLSADPQAADDLAQDT
                     FLRALGSLHRFEGRCSARTWLLAIARRAVVDSLRYAAARPRLSDVPDWRLAVERAQPRG
                     LPGFDDGVALLDLLAALPDERREAFVLTQMMGLPYAEAAELSNCPIGTVRSRVARARAT
                     LIGLLAENDTVAGAGVLAGTGVPAGAGAPAALAA"
     gene            complement(14426..15130)
                     /locus_tag="IGS71_RS07790"
                     /old_locus_tag="GCM10017557_16090"
     CDS             complement(14426..15130)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994797.1"
                     /locus_tag="IGS71_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16090"
                     /product="hypothetical protein"
                     /protein_id="WP_190849786.1"
                     /transl_table=11
                     /translation="MTAGWGVRTVRAAVFAVVCVLLAALGHVMMSGSPVAWWSVAAGTA
                     ATGGVGWCLAGRERGLPLIVSVVVVVQGLLHSSFSLAQSATGRVTPGQGTSQGTGSTRM
                     HPMSMDAMDAMDMGSMGSGHMSAGHMGSGSMGQPAHDMGGMSSLGMLAAHLVAALLCGL
                     WLAYGERAAFRILRAVAGRLAAPLRLLLALPTPPHRPRLPVRRVSSDRSPRRLLLAHAI
                     TSRGPPAGSAAT"
     gene            15369..15809
                     /locus_tag="IGS71_RS07795"
                     /old_locus_tag="GCM10017557_16100"
     CDS             15369..15809
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039201.1"
                     /locus_tag="IGS71_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16100"
                     /product="SRPBCC family protein"
                     /protein_id="WP_190849787.1"
                     /transl_table=11
                     /translation="MVLIHLCRDTPLSADEAWRRLTVWERHADVVPLTRIQVVTEPPRG
                     AGTVFVARTGVGPVAFDDRMEVVVWQAPRDGAPGLCRLVKRGRVVLGWAEIEVRPAAGD
                     GSQVVWREEAGVRGLPRAFDPLLGRATRWMFGRVVDRLLSRP"
     gene            15987..16844
                     /locus_tag="IGS71_RS07800"
                     /old_locus_tag="GCM10017557_16110"
     CDS             15987..16844
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471353.1"
                     /locus_tag="IGS71_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16110"
                     /product="HD domain-containing protein"
                     /protein_id="WP_190849788.1"
                     /transl_table=11
                     /translation="MFSKGNQSNKDNEGNEGNEAKGITRRTALGRGAGIAAIGAVSTFA
                     ATSVNPSPAAAASGTAPLGNASNSSTATLPTDVAGIRLPDSEVARAAAALARGVSSVTL
                     FNHVMRTYLYGSLLFDRRGVRYDRELVFVGAVLHDLGLVEAYQTPDERFEVDGADAAQR
                     FLREQRMPAERVAVVWDAIALHTSNGIATRKRPEIAMIAVGSSVDFAGEGVEQIPSDAL
                     ADILTAFPRENFKQHALDDMVSLCRTKPMSVLMHPFAEVGRRHIPDFPVPTVEDLLFAA
                     PFEE"
     gene            16930..17589
                     /locus_tag="IGS71_RS07805"
                     /old_locus_tag="GCM10017557_16120"
     CDS             16930..17589
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964420.1"
                     /locus_tag="IGS71_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16120"
                     /product="ATP-dependent endonuclease"
                     /protein_id="WP_190849789.1"
                     /transl_table=11
                     /translation="MNDMGRFRQAVVAWAAGGAEASGAGASARELAAGVGLRTVVLVEG
                     GSDQVAVEALAARHGRNLDDEGVSVVPLGGATSIGRFVDLCGPQGLDVRLAGLCDVAEE
                     RFFRRALERAGIGSGLTADGLESLGFYMCDADLEDELIRALGADVIQEVVREQGELRAF
                     RTFQNQPAQRERTVEQHLHRFMGTHSGRKAQYAQELVASLDLDRTPPPLERLLAHL"
     gene            complement(17702..18868)
                     /locus_tag="IGS71_RS07810"
                     /old_locus_tag="GCM10017557_16130"
     CDS             complement(17702..18868)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385643.1"
                     /locus_tag="IGS71_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16130"
                     /product="XdhC/CoxI family protein"
                     /protein_id="WP_190849790.1"
                     /transl_table=11
                     /translation="MLDIAEELNRWVAQGRDFAVATVVAVGGSAPRHPGAALAVDTDGT
                     AIGSVSGGCVEGAVYELCRQALEDGEPVLQRFGYSDEDAFAVGLTCGGIIDILVTPVRA
                     SSPGRTVLASALSAAAHKEAAALARVVSGPGQLLGRALLVRPDGSYEGGFGAHPELDRT
                     VAEEARAFLDAGRTGTLEIGERGSRCGAPLTVLVESSVPPPRMIVFGAIDFASALVRVG
                     AFLGYRVTVCDARPVFATAARFPEADEIVVEWPHTYLERTEVDARTVLCVLTHDAKFDV
                     PLLRLALRLPVAYVGAMGSRRTHLDRNERLREVGVTERELARLRSPIGLDLGARTPEET
                     ALSIASEIVASRRGGSGVSLAGARTPIHHDGSAGSLASMPTCAVGSVA"
     gene            complement(18960..20420)
                     /locus_tag="IGS71_RS07815"
                     /old_locus_tag="GCM10017557_16140"
     CDS             complement(18960..20420)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125408.1"
                     /locus_tag="IGS71_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_16140"
                     /product="NCS2 family permease"
                     /protein_id="WP_190849791.1"
                     /transl_table=11
                     /translation="MTQQSVEPGTTAADDAGEGPRIAAGRSWLDRYFHISLRGSSVARE
                     VRGGVTTFMAMAYILLLNPLILSGKDVAGDTLGRQALITATAFAAAFATLLMGFVGKVP
                     LALAAGLSVSGVLSSQVAPQLTWPQAMGMCVLYGVVIMLLVITGLREMIMNAIPLALKH
                     AITMGIGLFIALIGLVKAGFVHQGKGTPVTLGPNGELSGWPVLLFAVTLLAVFMLQARG
                     TPGAILIGIVGGTVLAVILNALDVIDPDQWASGAPELHGSAVSMPDFSLFGDVEFGGWG
                     EVGAMAVGMIVFTLVLAGFFDAMATIIGVGTEAGLADDKGRMPGLSKALFIDGAGGAIG
                     GVSGASGQTVFVESATGVGEGARTGLSSVVTGLFFAACLFFTPLTAIVPGEVAAAALVV
                     IGAMMMTNARHVDWADRSTAIPVFLTVVIMPFTYSITAGVAAGVISYVAIKIAEGRARE
                     IGAFMWGLTAVFLVFFALSPIESWLGVN"
     misc_feature    20528..20544
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
ORIGIN
        1 ctccggcgtg cgccatctgg tcggcaccac ggccgccgcc cgcatcgcgg atccggccga
       61 tccgtcgagg gtgtacgcct ggctcctgga acgctcgatc cgcccggccg gtgacgagat
      121 cgtccacacc tggaccggcg accggctgtt ggagtcggtg acctgggcgg cgtaccgcct
      181 cgaactgcac tacgagtccc ggcccgaccc ggtcttcgac ggccgccccg ggttccctct
      241 gaccaccacc cggcggtgca cgtcgatcga actgcacgcc tcggcgcagg caccgacttc
      301 gctgcgtcgc tacaccctcg actacgtcgc cggccggccg accgggcaca gcctgctcgc
      361 cggggtgacc ctctccgggc acggcgcgga cggcgccgtg gccacctttc cccggctggc
      421 gttcggctac accgcaggtg gcgctttcac cgtacgggcg gtcgatgcgg ccgtcgcccg
      481 tgtgctggcc gcaccgggcg gcaccgtcgc cgacctgacc ggtgacggac tgccggacgc
      541 ggtctcgctc ggcccgacgc cgaccgtggc ccgcaaccgc ggcggactgg ccttcgatcc
      601 tccgcgccgg ctggcccgca ccggtctgcc gggtgtcccg cccgacgccc tcaccctcgc
      661 cgccgacctc accggacgcg gccgcgtcga cctggtcacc gtcggccgcg gtcttcggca
      721 tcgctacccc gtcgacggcg cgggtgtcct cggcgcgccg gtggtcagcg cctacgcgcc
      781 gacgttcgcg ccctgggacc ccgacgtacg cctgctcgac ctggacggag acggcgccgc
      841 cgacctgctc aggctcggcg acggcgtact ggccacggtg tccacggcag gcggcgcgga
      901 ggactggcgg cacgtcgacc agaaggcggt cggcggcgac gatccgctca tcggcgtcga
      961 cctccggtcg cccgacatcc acgtcgcccc gatgaccggc gacggcctgg tcgacctggt
     1021 cgaggtgcgc agcggacggg tgcggtactg gcccaacctg ggcaacggcc gctggggggc
     1081 gccccgcacc atggccggca gcccgttgct gcccgccgac taccggacgg accggctcct
     1141 gctcaccgat gtcgacgggg acggctgcgc cgacctggtc tacgtggaca ccgacgcgct
     1201 acggatctgg cccaacctcg gcggcgccgc gttcgaggcc gagatcaccg tcgctccggt
     1261 acctggtgtg gcggccgagc gggtggaacc ggtggacctg cgcggtaccg gttgcgtggg
     1321 gctgctgctg accacccggc atcggacgcg cccgatggcc tgcctggtcg acctcgacgc
     1381 caagccgtac ctgctgaacc ggatcgacga cgggatcggc cacgtcaccg agatcggcta
     1441 cggcacatcg ccggccgagg cacggcggga tgccgaacga ggcaggccct ggtcgacgtc
     1501 gctgccgttc tgcctgcccg ttgtgaccag cgtcgtacag acggaagccg ctgcggctgc
     1561 ccgcacgagc cggttcgcct accacgacgg gcactgggat ccggcactgc gccggttcct
     1621 cggtttcgcc cgggtcgacg aggtggagga gggcgacgcc ggcgtcgagg cgctgctcaa
     1681 gcgcaccgag ttccacctcg gacgtacccc cgaacgcacc gaccgcccgc ccgcccacga
     1741 cgaacggctc gccgcacagg tgctgcgcgg ccgggtgatc cgctccgccg gccatcgggc
     1801 cgacgccgac ccggacgtcg agcccccgct gttcgacgtc cggcagacct ggcaggcgca
     1861 catcgccgag gtgggcggcg ccaccgtcgc gtccccccgg ctgacggagc ggtgggagaa
     1921 ccatctgcac ggtgccgcca cgccctggcg caccaccgcc accaccaccg tcggctggga
     1981 cgacttcggc aacgtcaccg agcaacggca gcgcaacacc ctcgcagccg acccgaccgc
     2041 cactcaggac ctgcgcaccg tcaccgagta cgccacggat cccggccgct ggatagtcga
     2101 ccggccggcc cggatcaccc agaccgacgg caccggcacg atcgtcgacg ccagaattct
     2161 gcgctacgac gggcagccct tcacgggcct gccggagggg tcgctgatac tcggtctcgt
     2221 cacgtccgag gaacggctgg ctctgcgcga cgaccagatg agcgcggtgt acggcgccga
     2281 tccgcccgat ctcaccgagc tcgggtacca ccgcaggacg ggggaggacg gctggtgggt
     2341 gtatgtccgc cggtacgacc gctccacctc cggcactctg gtcagcctcg acccgcgcgg
     2401 taccccggtg accctgtccc tcgacaccga ccggctcttc ccggtgcgcc gcgccgacgc
     2461 ccgcggcaac gtcgtcgagg cgaccgtgga ccggtacgcc ctgcggcccg ccgccctcac
     2521 ggacggcaac ggcggtgtcc gccgcaacac ctacgacgcc ctggcccgcc tggcggccga
     2581 gttccgtccc ggcgacgagc cggacgcgcc cacgatcacg taccggtatc tgctcgatcc
     2641 gaccggaccg gcggtggaga ccgtcgagta cccgagcgcc gaccgcggtg acaaggtcac
     2701 ctcccgtcgg ctggtcgact ccgacggccg ggagaccggg gtggcccgcc tcgacggcga
     2761 cggttcctgg ctggtgaccg acgcggtgtg gcgcaacgcc cggggcctgg cggcccgtca
     2821 gtacctgccg ttccggacgc cggtggggcc cggcccccag gccccgaccg aggccctgcc
     2881 gcatctcgcg accagcttcg acgcgctcgg tcgaccgctg cgggtggacc tgcccgacgg
     2941 cgcgtatcgg ctcggtgtgc acgccccggg ccggtccgac atgtgggacg aggaggacac
     3001 ccgggccggc ggcgcccatg agggcacgcc caccagttac cacctcgacg cggccggcag
     3061 ggttgccgag gtcgtgtccc ggtccggcgg ttccgaggtc gtcacgcgct accggtacga
     3121 cctgcgcgac cagcccgtgg agatcacgga cgccaacggc aggcccacca cggtcaccta
     3181 cgacctgctg ggacagcgga tccgggtgga cgacccggca accggcaccg tcgtcttcgt
     3241 ccacgacgcg gcgggcaacc tggtggagcg ccgcaacgcc gccggccagc acgccggcta
     3301 ccggttcgac gagctcaacc ggatggtccg cagcagccag gacggacaac ccgaggtggt
     3361 ctaccactac ctcgaccagg acgacgtcgg caacggcgga gccccgggcc gccgcatcgg
     3421 tcgtctcgcc gcggtcgacg acgtgcgcgg caccctcacc ttcgactacg acgtgcgtgg
     3481 cgaggtcgaa cggcgccggg tgtccctgac cggcggggcg gaccacgcgc tccggcgccg
     3541 caccgaccgc ttgggacgcg tggtgtccat cgcctacccc ggcagtgccc ccgacgcccc
     3601 cggcccggtc ctgacctacc ggtacggccc gcgaggactg ctgacctccg tctccggagt
     3661 catcgactcg atcgactacg acccggcagg cagcccggtg acgaccgtgt acaccggcgg
     3721 agtgcacgtc acgcggcagt acgacatgct ctcccggatc gccgcgaccg aggtcaggga
     3781 cggagccggg ctgctcctcg accaggagac actcacccgc gaccacgccg gacacgtact
     3841 caccgtgtcc ggaccgacgc ccgccgacgc gtggacgtac cgtcacgacg acctgtacca
     3901 actgacccgc gccgagccct cggaaggccc cgccgtcgac ttcacctacg acgctgcggg
     3961 caacatcctc tcccgcagcg acgtggggac gttccgctac ggtgagcgcg gtgccccacc
     4021 ggtatgcgtc accacggcgg gagcacagca gtacggctac gacgcggccg gacggcagac
     4081 cagcggcccc gccggaacac tcacctacga cggacgtgac cgcctcgtcg ggatcgccgg
     4141 acccgccggc gccgaggtgt ccttcggtgc cttcggcgaa cgtgccgtac gggagatgac
     4201 ggtcggcggc cggatccggc ggaccgtact cctcgacgac ctggtcgagc tgcacgacgg
     4261 ccaactgctg tgcatcgtca ccgacggccg cggccggatc gggcaattcg tccccggcgg
     4321 gtcgctcacc cgatggcaca ccgaccacca cggctcggtc cgtctcatga ccaccggcac
     4381 gggcacggtc gtccaacgga tcgcgtacga cccgttcggc aggattctcg ccatccaggc
     4441 cggcggagac cggcccaggg acacgtacga cggctacgaa ctccttgagc agatggccct
     4501 gtacctgtcg ccgaagcgcc cctacgaccc cgtactgggc cgttacctcg tccccgacac
     4561 ggtcgccgcg gacctgtggc atccggtggg cctcaaccgt tacgcgtacg ccgccaacga
     4621 ccccgtcacc gtacgggacc ccgcaggccg tgcctggtgg cacatcgcgc tggccatcgt
     4681 ggccgtcgtg gccgtcgtgg tgctgaccgt ggtcaccttc ggggtcggac tgatcggctt
     4741 gggcgccatg atcggggtgt tcgccgcgat ggcggtcggc ggcgcggtcg gcggcatcac
     4801 cgcggcccag gccggcggcg acatcgtgct gggtgtcctg ctcggtgcgg cgctggccgg
     4861 tgccgcggcg ttgggcgggg cgctggccgg ggccggtttc gcggccgcgt tcggcgccaa
     4921 gtccctcgtg accttcctgc tctccggagc ggtcagcggg gcgctgctcg gtgccgcgac
     4981 cggattcgcg gccgggttcg ccggcggcac gggttcgctc ggcgagatct gggagaagac
     5041 ctggcaatcg gccctggccg ggttcgtcac cggcctggtg ttcgggctgg ccggctacgg
     5101 attcgcccag ggctggttcg gtaccgggaa catcagcccc cggctgccca ccggtgcgga
     5161 gaccgaacgc gcgctcgccg aaggcgccaa ggccgccgga caggcggcga acaccggcgc
     5221 cggtgccgcc gccatcggtc agggcgcgac caccaccgcc ggcagcctcg cgggctccgc
     5281 gctcaatttc ggcgcgccga ccggtttcaa cgtcctgggg acctttgtct tcaaccccgt
     5341 cgccggaacc ctgttcatcg agtcggtctc ggtcctgttc gccttcgacc tggtcgacga
     5401 cgtcatcgac ctcgtcaaga acagcggcac cggctatacg aagagcggca ccttctgacg
     5461 gggcggcagg agacctgatg cccgatcttg ccggcgacgg tggagccgct ccccgctgtc
     5521 gttcatcctg cttcctcacc cccgatgatc ttgtcctggg tgatgggagg gcatcgccac
     5581 caactgctcg tccgacacgg gcacaggggg cccggacagg gccttctcgg caggcttcac
     5641 ggtctccaac tccactgggg cgtgtcagga gccagccggt gtccccgaag gcgtcaggcc
     5701 caactcggcc aggagttcgg cttgacgctg ccggtaggcg gtcacgttgc gcagcttgat
     5761 ctgttcgtag ccgcgcaccc tgtcgggcag ttcggcgagt tccttgacga gcccggggtc
     5821 ggattcgacg gcggacaggg ctcgcgcgac ggtgcgtcgg tagtcctcga cgagggagcg
     5881 ctccacgcgg cggacgtggg cgtacccgaa gagatccagg ggcgttccgc gtagtcggcg
     5941 catcgcgcgc agcacccgga acaccggccg gaaccagcgg cccagactga tcttgcgctt
     6001 gacccccaga gccctgagga cgggcgggtg gagccggtag gagaagcgtg agccctcgcc
     6061 gaactccgct gcgatctgct gccgcagggt ttcgtcgagt gcgaggcggg cgacctcgta
     6121 ctcgtccttg tacgccatga gtttgtacag gtggtgggcg accgcttcgg tgacggcggt
     6181 ggccggcgct tccctcgcgc ggacctgctc gacgtacagg gcgtagctcc gtgcgtactt
     6241 ctcgttctgg tactggatga ggtcggggat gcggatgtcg aggagccggg ccaggtccgt
     6301 gccgggctcc gccgcgacca gcgaccgtat ccgtgccacg gccgccgcta ccgcgggggt
     6361 ggcgaccgca ggggtggcga ccgcgggggt ggtgaccccg gggacggcgg gagggctggg
     6421 cggcgatgcg gtggtggcgg cggtggccgc tgcgggatcc gcgaccagtt gccggcccct
     6481 gcggaacgct tgcaggttgg cctggaccgc cgtgccgttc agggtgatcg cctcctcgat
     6541 cgcctccgcg ggcagcggca tcgctccgct ctggtaggcc acgccgagtt ggaggacgtt
     6601 ggcgaaccgg tcctcgccga agagggcttc ggaccgggcg cgggcgtcga ggtagagggc
     6661 gcgggcgctc gccgcgcgga tggcgtcctt caccggcccc tgctcgggga aggcgacctc
     6721 ggtgtcgacc accatgcggc cggtggggac ctcggtcgtg gagaccacgg cggtggtgcg
     6781 gccggggtcc gcggcagcga ggtgtttggg gtcggcgccg acgaggatgt cgcaggccag
     6841 atagaggtcg cattccgacc tggccagttt ggccgcctgt gccacgacgc ccgaggtgat
     6901 cttgatgtcg gagacgaccg ctccgccctt ctgcgccagg ccggtctggt cgagggtgcg
     6961 gacgtgtttg ccgtcgagta cggcggcggt cgcgaggatc tgcgcgacgg tgacgacacc
     7021 ggtgcccccg atgccggtga tgcgcacggt gaacgagtcc tgaccgcctt gaccggcttg
     7081 accgtctcgg cggtcgggct ccggaaggtc ggccgcggcc agctcaggcg ttttcggccc
     7141 ggacttgcga ccgctcggtg tcacggtgac gaacgagggg cagtcgccgt cgaggcagga
     7201 gaagtcgagg ttgcacgagg actggtcgat ggcggtctta cggccgaact cggtaccgac
     7261 cggctgcacc gacagacagt tggacttggc tccgcagtcc ccgcagccct cacagatccg
     7321 ctcgttgatc atgaccctgg tcgtgggtgt ggccacggtg ccgcggcgtc gcttgcggcg
     7381 cttctcggcg gcgcactcct ggtcatggat gagtacggtg acgccgggag tggccgcgag
     7441 ttcctcctgg ctgctgatga ggtggtcgcg gtggcggacc acgacaccct tcgggagtac
     7501 ggctttacgc agccggtcgg gagcctcgct ggtgatgatc accttggcgg cgccttcgag
     7561 gagcagcagg gcggccaccc ggtcgacggg cagcgccccc acgggctgtt gaccgccggt
     7621 catggccacg gcggagttgt agagcagttt gtaggtgatg ttgacgccgg aggcgacagc
     7681 ggccctgacg gcgagactgc ccgagtgcat gaaggtgccg tcaccgatgt tctggacgaa
     7741 gtggtcgtcg tcgaggaagg gggccatgcc gaaccactgg gcgccctcgc cccccatctg
     7801 cgtcatgccg acgacatggc ccacctgttc cggttccatg aacacggcca tggtgtgaca
     7861 gccgatgccg gcgccgacca gcgagccgtc ggggaccttc gtcgaggagt tgtgcgggca
     7921 gcccgagcag aagtacggag tacgcgccag gagcggcagc gagacccgtt cgcgcggacg
     7981 cggggtcggt gacgatgacg atgacgatga cggtgcgcgg aacccgtggt cggccaggcg
     8041 cctggcgaag ccggcggcga tgctctcggg gtcgagttcc ccgaccgcgc tgaacagcgt
     8101 cgtcccgtcg ggaccgtgtt tcccgtggac ggacggggcg ccggtgatgc cgtaaagggt
     8161 gtccttgacg gccgcctcga cgaaggaccg cttctcctcc accacgatca cctcgcgcag
     8221 tccggcggcg aactcacgga cgacggtggg ttcgagtgga tggatgacag ccagtttcag
     8281 cagccggatg ccgagtcggg ccaggccttt gtcgtccagg cccagactgc gcagggcctg
     8341 ttgtacgtcg aggtgggtct ttcccgcggt gatgatgccg atccggtcgt ccggcgtctg
     8401 gttgaggatc cggttgacct tgccggcccg caggtactcc tggaccagcg gaagtcgcac
     8461 gtggtgcagg ctctgctcca gcttcgccag gcccgcgccc agcagatgcc cgtcgggccg
     8521 gtgggtgtag gccccggagg gcaggacggg tggctgccag accggatgca ccacggcggt
     8581 gcccgccgcg tccgcgacat tggcgacgat cttcatcgag gcccacacgc cgctggcccg
     8641 tgacagttcg acggcgtgca gcccgtagtc caggatgtcc tgcgagtccg ccgggtagaa
     8701 gatcggcacg gcgaggtcgg ccagggcgag ttccgaggcg cagggcaccg acgaggactt
     8761 cgccgcgggg tcgtctccca cgagggcgag ggctcctccg cggggagagg tgccgacgag
     8821 gttggcatgg cgcagggcat cggtcgcccg gtccaggccc ggcgcctttc cgtaccagag
     8881 cccgacgacg ccgtcggtcc gcagcctgcc cacctctccg gccaactggc tgcccatgac
     8941 ggaggtggcg gccagttcct cgttgaggcc cggcctgtgc accacgccgt gctcggtgag
     9001 cagcggaacc cggcgcatga gttccagatc gaacccggcc aggggcgacc cttcgtaacc
     9061 ggagacgaag gccgcgttgt ccagacccgc acgccggtca tgcctgatcc ggtcgaacag
     9121 caggcgcacc agggcctgca cgccggtgag gtagaccctg ccctcctcct gcagataacg
     9181 gtcctccagc gtgaagccgc tcgatgtcgg cgtcggtgtc ggtgtcggtg tcagtgtcag
     9241 tgtcggtgtc ggtgtcgtct gcgtcatctg cgtcgtctgc gtcgaaacac ctgcgggggt
     9301 catgcgctca cctaactcac gactgggcag tacgctgtcc aattggccca gatactagga
     9361 gtcaggcagg gatactggtc aatactcctt gccattgact ggtccaatgg cccgatgctt
     9421 gactggaaat ccggtccgcg gaaaggtcat cggtacagtc atggacgacc tcgacacatc
     9481 cctgctgcgc ctgctgctgg aggaaccacg agccggcatg cgcgagtacg cccgcgtgct
     9541 gggtgtggcc agaggcacgg tgcaggcccg gctcgcccgc ctggaacagt cgggcgtcat
     9601 cgccggctac gccccgcagt tgagcgcgcc cggcatgggc tatcccgtac tcgccttcgt
     9661 ccatctgcac ctggcgcagg gcagattgga cgagatcacc gcggcactgc acgccgtgcc
     9721 cgaggtcctg gaggcgcaca gcatcgcagg cgagggtgac ctggtgtgcc gcgtcgcagc
     9781 ccgggagaac gcccacctcg aagacgtcat ccagcagttg atcaaacttc ccggcgtcgt
     9841 ccgcaccaag acggaggtgg tcctcagcga gcgggtcgcg ccgcgcaccc tgcccctggt
     9901 gctgcaggcc gacgatcgcc gccgccgata ggacgctgaa cgggggctca tcgggcatcg
     9961 cccgcgcccg accgaccgag cgcggcgaga ccggcgttct tcagtggtcg cggtgcgtgg
    10021 cgtggtgggc caggtccgtg agggtggtgg tgatgtccgg gggcagggtc gtttcggtca
    10081 gggcctggcg ggcctcgtcg aggcgggtgg tgatgaggtc ttcgatgtgg gagcgggcgc
    10141 ccgtgtcggt gaggatggtc cgtgcctcgg tcagggcggt ctcgtcgagg ctggtccggt
    10201 ccatcagctg ggtcaggcgg gcacgttggc ggggatcggc gtcgcgccag gccagggcga
    10261 gcagcgcggt gtgcttcctg tgacacaggt cgtcgccgga gggtttgccg gtggtgggtg
    10321 cgtgtccgaa gacgttgagc aggtcgtcgc gcagttggaa ggcctccccg acggcgagcc
    10381 cgaaccgggt cagcgcctcg atgatcgttt cgtcggcgtg agccagcacc gctccgatgt
    10441 gcaggggcca tcccacggtg taaccggctg tcttgccgcg tgcgatgcgc agtgcgtgcc
    10501 cgacgtcctc gaccgcgccg tgccccacgt cctcgaccgt gccggccggc gctgtgtccg
    10561 tgcccaccag gtccaggtac tggcccacca cggtctgggt acgcatcgtc gccaaggccc
    10621 gcccgacccg ccgccgcctg tgatcgtcga tgtccgcggt gcccaccaac tcgtaggacc
    10681 agcccagtgc gatgtctccg agcaggatgg cggtgtcgcg tcccagcttc tgtgcctgcg
    10741 catgacctcg gtgacgggcg gcgaccagat gctgggccgc gggccgcccc cgccgggttt
    10801 cggcatcgtc catcacgtcg tcgtgcagca ccgcgaacgt atggaacatc tcgaaggacg
    10861 ccgccacccg ggccaccgcc ggtggcaggg gccccgtgcc gccgcccgcc cgccagccca
    10921 gacagcacaa caacggccgc agctgcttgc cgccggccaa cgacccgcgg acccagccca
    10981 ccagctccgc gacctccggc tccgccgaca acgccccctg ctcctccagg aaccgcgcca
    11041 gcacctcttc cacagcacgg aaatcctcag cgcacgagaa accgccccgg cggccctccg
    11101 tgtgcccgac ggacgcagcc tcccgcacca ccacacggtc atccaccatg gaccgaccgt
    11161 aaagcgaccg tctccggctg accactcggc acccgaaagc ccgaaagaca gtccccgaaa
    11221 ggcagccctt ggccggcagg tggctcctgg tagcctgcgg ctcatgagcc acagccactc
    11281 ggcgggcgac gtcttcttcg ccgactgccc cactcggctg gcgatcgaca tcatcaccga
    11341 caagtgggcc gtcgtcgtcc tcttcgcact gagccgcaaa ccgtgccggc acggcgaact
    11401 cgtcggcctc atcggcggca tctcgcgcaa ggtactgacg cagacgctgc gccgactcca
    11461 gggctacggc ctcgtcgacc gccgtgcgta cgccgaagcc ccgccacggg tcgagtacag
    11521 cctgaccgac ctcggccgga cactcgtcga gcccatctcc gtcctcacgg actgggcgag
    11581 gtcctacggc gaagccatcg tcagctttca gaatgcgaac gatgcgaacg aagaggaccc
    11641 gcccgagggt tcgaccacca tgtgacgcgg ctgtcgcgcc cctgcagggg cgcggctgcc
    11701 gcaggtgcgc actaccggcg cgggcggccc ctctcttcgt cgtcgtccac ggcgacgtca
    11761 tcgatgacga cctgctcctt gcggacctga ccgctgacgg tctcgttctc catgacctcc
    11821 tcggtgctca gccgcactcg ttccatcggc accgcctcgg tctgtacgac ggcgcgctcg
    11881 gcgtgcagag ttacctcgtg ttcggcctcg cggaactccg gccccgacat ggcctcgtcg
    11941 cggttcgcct ccgtgatcgg ctcccgcacg acacgtgcct cctcgtggcg cagaggcacc
    12001 gtctgctgca cctcttccgt caccacgtac ttgcgcagcc gcgcccgccc cgactcgtac
    12061 cgctcggtag cgacccgcat gtgctcctcg gaccgggtca ccgcgatgtc ctcgggcatg
    12121 tccgtgtccc ggcccatggc acccgcggcg ccggtcgccc tcccggtacc ggcggcgccg
    12181 gtggtgccgg cggcccccgc agcgccgacg gtgccggcgg cttcggcggt gcccgcgtgg
    12241 gcccagccgt ggcccggccg gttggcctgc tgccaggcgt cgtcccaggc gatgccgtaa
    12301 tgctcgtaca gccggacttc ttccgactcc gacaggtggc cgccgccgtc gacgtcgacg
    12361 ttgggcgcct ccttgacctt gtccttgggg tagggcacct caaggtggtc ctcgaccatg
    12421 accgcttctc ggatcggcac gaacgactcg ttggtaccga agaagccagt cttgatgctg
    12481 acccattccg ggcgaccggt cgcgtcgtcg tagaagacgt ggctcgcctc accgatcttg
    12541 ctgccctcgg cgtcgtacac ggggtgttcc agtactgccg ggatctgctc ctgggtgatc
    12601 atcctccagc accctccttc tgagtccggt gtccacgttc gggtcaccgc gacagaaggg
    12661 acgaaacctg ataaatggga acagacaggt agaaaacgta actactgcgc caggtacgcc
    12721 acgggaaggg cgtctcctgg cgagagttgc ccgagcagcg gcctcggtga aatccgctcg
    12781 accggggcag gcgaaggccg cgatcatggt ggcctcactc ggcagctgta aggaagtcga
    12841 ttcgcgatgc cagccattcc cgccgacccg accgtgctgc atccgatgcc cgaccagcct
    12901 cgtgtggtgc tgctgaaacc gctggtcacc tcgccgctga tcgaggtcgg agagttctcc
    12961 tactacgacg acccggacga tcccaccgcg ttcgaacgcc gcaacgtgct ctatcactac
    13021 gggccggaga agctggtcat cggcaagttc tgcgcgctgg gcgagggggt gcggttcatc
    13081 atgaacggcg ccaatcaccg catggacggc ccctccacgt ttcccttccc gatcatgggg
    13141 gcctcgtggg ccgagcactt cgacctgatc accggcctgc ccggccgggg cgacaccgtc
    13201 gtcggcaacg acgtctggtt cggacaccgg accatgatca tgcccggcgt ccgcatcggc
    13261 cacggagcga tcatcgcttc cggttccgtg gtcgtcgacg acgtgccgga ctacggcatc
    13321 gtcggcggca acccggccgg actcatccgg cgccgctaca gcgatacgga catcgcccgc
    13381 ctgctggccg tcgcctggtg ggcctggccc acccagcaca tcaccgagca catccgaacg
    13441 atcatgtccg gcagcgtcga cgacctcgaa gccgcggctc ccagcgagca gtgacagccc
    13501 tccgggtgcc ggcctgagca gccggcaccc cctcccgtca ggcggccagg gcagccggcg
    13561 cgccggcccc ggccggtacg cccgtccctg ccagtacgcc cgccccggca accgtgtcgt
    13621 tctcggcgag caggccgatg agggtggcgc gggctcgggc caccctggaa cggacggttc
    13681 cgatggggca gttgctgagc tcggccgcct ccgcgtacgg cagccccatc atctgggtga
    13741 ggacgaacgc ctcccgacgt tcgtcgggca acgctgccag cagatcgagg agcgcgaccc
    13801 cgtcgtcgaa gccgggcagg ccgcgcggct gagcccgttc gacggccagc cgccagtccg
    13861 gtacgtcgga caggcgcggg cgggcggcgg cgtaccgcag actgtcgacc acggcgcggc
    13921 gcgcgatggc cagcagccac gtacgggccg agcagcggcc ctcgaaccgg tgcaggctgc
    13981 cgagcgcccg cagaaacgtg tcctgggcca ggtcgtcggc ggcctgggga tcggcggaga
    14041 ggtaggccac gtagcgcacg acgtcccggt gcagggcgcg cacgaaacgg tcgacggcct
    14101 ccgggtcgcc ggtccgggcg gccagcgccc aggcggttat cgactcgtcg gcggacgccg
    14161 ccgtgtcgct cgggcggctc ggccggctcc gacggcttgg gccgctcggc tgactcgggt
    14221 ggttcggctg actcgggtgg ttcggtccgc tcacgtcgtg tgaaacgggc agggcaggag
    14281 tgatcaccag gtgtccttct cgggtcatcc gtgatccggg ccgagggcgc gcacgcatgt
    14341 cggtccggcg aggggattcg gccgtacgcg gaggtacggc cgaggcccga ggcacgcgtg
    14401 gcggcgcccc ggggatccgg ctgtctcagg tggcagcgga tcccgcgggc ggaccccgag
    14461 aagtgatggc atgggcgaga aggagccgcc gcggcgaccg gtcggaggaa acacggcgaa
    14521 caggaagccg cgggcggtgc gggggcgtgg gcagcgcgag cagcagccgc aggggggcgg
    14581 ccagccgtcc ggccaccgcg cgcaggatgc ggaacgctgc gcgttcgccg tacgccagcc
    14641 acagaccgca cagcagcgcg gccaccaagt gggcggcgag catcccgagt gaggacatcc
    14701 cgcccatgtc gtgcgccggc tggcccatgg agcccgaacc catatgtccc gcactcatat
    14761 gtccggaacc catggatccc atgtccatgg cgtccatggc gtccatggac atgggatgca
    14821 tgcgtgtgga gcccgtgccc tgactcgtgc cctggcccgg ggtcacccgc cccgtcgccg
    14881 actgcgcgag cgagaacgac gagtggagca ggccctggac gacgaccacc accgacacga
    14941 tcagcggcag tccgcgctcc cggccggcca ggcaccagcc cacgccgccc gtggccgcgg
    15001 tcccggcggc cacggaccac caggccaccg gggagccgga catcatcacg tggccgaggg
    15061 cggcgagcag cacacagacg accgcgaaca ccgcggcccg aactgtgcga acaccccacc
    15121 cagcagtcat gacgggcctc atcctcgcat tcgtcgcgcg tgcgtcatgg ggaggtacgg
    15181 gtattgcccc cgtccggcgc tcaacatgga acacgtgatc cagaacacac ggcagggccg
    15241 gaactgtacg cgggtccgga ccgacgccct gccgcgccga atccgaatcc gaatccgaat
    15301 ccgaatccga catcagcgga ggcggctgcg gcagggcgtt ggcgctgtcg tgtgcctacg
    15361 atccgggggt ggttctcatt catctgtgcc gggacacccc actgagcgcc gatgaggcgt
    15421 ggcggcggct caccgtgtgg gaacgtcacg cggacgtcgt gccgttgacg cggatccagg
    15481 tcgtcacgga gccgccgcgc ggggcgggca ccgtgttcgt ggcgcggacc ggggtggggc
    15541 cggtggcgtt cgacgatcgc atggaggtcg tcgtctggca ggcccctcgg gacggcgccc
    15601 cgggattgtg ccgactcgtc aagcgcggcc gagtcgtcct gggatgggcc gagatcgagg
    15661 tgcgtccggc ggcgggagac ggttcccagg tggtgtggcg ggaggaggcg ggagtacgag
    15721 ggctgccgcg ggccttcgat cccctgctcg ggcgggcgac ccggtggatg ttcgggcggg
    15781 tggtggaccg gctgctgtcc cgtccttgag gaaccggggg cagcaggcgt cggtggtcgc
    15841 tcacatgggg tcccccagcc atgtcaaaaa ggagaaatgc gggcctggcg agaatcagcg
    15901 gctctccggc gttttcaccc ctgtcggtcc ggcagagccc attcgtacgc tcctggtgtt
    15961 gatcaccgct gaggaggccg acccatatgt tcagcaaggg caaccagagc aacaaggaca
    16021 atgagggcaa cgaaggcaac gaggcgaaag ggatcacccg gcgcacggca ctcgggcgtg
    16081 gtgccggtat tgccgcgata ggcgccgtct ccacattcgc cgccacctcg gtcaatccct
    16141 cccctgccgc cgcggcatca ggaacggcac ctctcggcaa tgcctcgaat tcgagtaccg
    16201 ccaccctgcc cacggatgtg gccggaatcc gcctccccga cagcgaggtg gctcgggcgg
    16261 cggcggcgct ggcacgtggg gtgtcctccg tgacgctctt caaccacgtc atgcggacgt
    16321 acctgtacgg ctccctgctg ttcgaccggc gcggcgttcg ctacgaccgt gaactcgtct
    16381 tcgtgggcgc ggtgttgcac gacctcggac tggtcgaggc gtaccagacc ccggacgagc
    16441 gcttcgaggt cgacggcgcc gacgccgccc agcggttcct gcgggaacag cgcatgcctg
    16501 ccgaacgggt ggccgtcgtc tgggacgcca tagccctgca cacgagcaat ggcatcgcga
    16561 ccaggaaaag gccggagata gcgatgatcg ctgtcggctc ctcagtcgat ttcgccggtg
    16621 agggggtgga gcagatcccg tccgatgctc tcgccgacat acttaccgcg ttccccaggg
    16681 agaacttcaa gcagcacgct ctcgacgaca tggtgtcgct gtgccgcacc aagcccatgt
    16741 cggtactcat gcaccccttc gccgaagtcg gccgccgtca catcccggat ttcccggtgc
    16801 cgaccgttga ggacctgctg ttcgccgcgc ccttcgaaga atgacgggcc ctgccggaga
    16861 cctcacccac cacgtccggc aacaaaagtc tgtggaacgg gtccgcccgc agttgcgaga
    16921 ctgggcccca tgaacgacat ggggcggttc cgtcaggcag tcgtcgcgtg ggcggccggc
    16981 ggcgcggagg catcaggggc gggcgcgagc gcgcgggaac tggcggccgg cgtcgggctg
    17041 cgtacggtcg tgctcgtcga gggaggcagc gaccaggtcg ccgtcgaggc gctggccgcc
    17101 cggcacggcc ggaacctcga cgacgagggc gtctcggtcg tgccgctcgg gggcgcgacc
    17161 agcatcggga ggttcgtgga cctgtgcggg ccccaggggc tcgacgtgcg tcttgcgggt
    17221 ctgtgcgacg tcgcggagga gaggttcttc cggcgcgcgc tggagcgggc cgggatcggc
    17281 tcaggcctca cggccgacgg tcttgagtca ctcgggttct atatgtgcga cgcggacctg
    17341 gaggacgagc tgatccgtgc cctgggcgcc gacgtcatac aggaagtggt gcgggaacag
    17401 ggcgagttgc gcgcgttccg caccttccag aaccagcccg cgcaacgcga gcggaccgtg
    17461 gagcagcacc tccaccgctt catgggcact cacagcggcc gcaaggccca gtacgcccag
    17521 gaactcgtcg cgagcctgga cctcgaccgg acaccacccc cgctggaacg cctcctcgcc
    17581 cacctctgac accccgcaca ccggtcccga gacgaccagc gagcccggga cggggacgga
    17641 tacggatacg gagacgggga cggggacggg gacggagacg gagacggata cggcctgaac
    17701 gtcaggccac cgagccaacg gcgcacgtcg gcatcgacgc caacgacccc gccgacccgt
    17761 cgtgatggat cggcgtgcgc gccccggcga gcgacacccc gctcccgccc cgccggctcg
    17821 cgacgatctc cgaggcgatg gacagcgcgg tctcctcggg cgtgcgggcg ccgaggtcga
    17881 gcccgatggg tgaccgcagc cgggccaact ccctttcggt gacgccgact tcacggaggc
    17941 gttcgttgcg gtccaggtgc gtacggcggg agcccatcgc gccgacgtac gcgaccggca
    18001 gccgcagcgc gagccgcagg agcgggacat cgaacttggc gtcgtgggtc aggacgcaca
    18061 ggaccgtccg ggcgtcgacc tccgtgcgct ccaggtacgt gtgcggccac tccacgacga
    18121 tctcgtccgc ctcagggaag cgcgcggccg tcgcgaagac gggacgcgcg tcgcagaccg
    18181 tcacgcggta gccgaggaac gcgccgacgc ggaccagggc cgaggcgaag tcgatcgccc
    18241 cgaagacgat catccggggc ggcgggaccg aggactcgac gagcacggtg agcggtgctc
    18301 cacagcgcga gccccgctct ccgatctcca gggtgccggt gcggcccgcg tcgaggaagg
    18361 cccgcgcctc ctccgccacc gtgcggtcca gctcggggtg tgcgccgaag ccgccctcgt
    18421 acgagccgtc ggggcgtacg agcagggcgc ggcccagcag ttgccccggc cccgagacga
    18481 cgcgcgccag cgcggcggcc tccttgtggg cggcggcgga cagcgccgag gcgagcaccg
    18541 tgcggccggg tgaggaggct cgcaccgggg tcaccaggat gtcgatgatc ccgccgcacg
    18601 tcaggcccac cgcgaaggcg tcctcgtcgc tgtacccgaa gcgctggagg accggctcgc
    18661 cgtcctccag cgcctgtcgg cacagttcgt agaccgcgcc ctccacacag ccgccggaga
    18721 ccgagccgat cgccgtgccg tcggtgtcca cggccagggc ggcgccgggg tgtctcggcg
    18781 cgctgccgcc gacggccacc acggtggcca cggcgaagtc gcggccctgc gccacccacc
    18841 ggttcagctc ttcggcgatg tccagcatct ctcggtctcc ctccgtctgc gggtgcgtcg
    18901 tggcttggcg cgcagttccc cgcgcccctg aaatcggggc gcctcctcac cgggtgcgcc
    18961 tagttgacgc ccagccagct ctcgatcggg ctcagggcga agaagacgag gaacaccgcc
    19021 gtcaggcccc acatgaacgc cccgatctcc cgcgccctgc cctcggcgat cttgatggcg
    19081 acgtagctga tgactccggc cgcgacaccc gcggtgatgg agtacgtgaa cggcatgatc
    19141 acgacggtca ggaagaccgg gatggcggtg gagcggtcgg cccagtccac atggcgggcg
    19201 ttggtcatca tcatggcgcc gatgacgacc agggccgccg ccgcgacctc gcccgggacg
    19261 atcgccgtga gcggggtgaa gaagaggcag gccgcgaaga agaggcctgt gacgaccgag
    19321 gacagacccg tccgggcgcc ctcgccgact cctgtcgcgg actccacgaa caccgtctgc
    19381 ccggaggctc ccgagacgcc gccgatcgcg ccgccggcgc cgtcgatgaa cagcgccttg
    19441 gacaggcccg gcatccggcc cttgtcgtcg gcgagaccgg cttcggtgcc gacgccgatg
    19501 atggtggcca tcgcgtcgaa gaacccggcg aggacgagtg tgaagacgat catgccgacc
    19561 gccatcgcgc cgacctcgcc ccagccgccg aactcgacgt caccgaagag cgagaagtcg
    19621 ggcatcgaca ccgcgctgcc gtgcagttcg ggtgcgccac tggcccactg atcggggtcg
    19681 atgacgtcga gggcgttgag gatcacggcg agtacggtgc cgccgacgat gccgatcagg
    19741 atggcgccgg gggtgccgcg cgcctggagc atgaagacgg cgagcagggt gacggcgaag
    19801 agcaggaccg gccagccgga gagttcgccg ttcgggccga gggtgaccgg ggtccccttg
    19861 ccctggtgga cgaagcccgc cttcaccagg ccgatgaggg cgatgaacag accgatgccc
    19921 atcgtgatcg cgtgcttcag ggccagcggg atcgcgttca tgatcatctc gcgtagcccg
    19981 gtgatcacca ggagcatgat caccacgccg tacagcacac acatgcccat ggcctggggc
    20041 caggtcagct ggggcgcgac ctgtgaggag aggactccgg agacggacag gcccgcggcg
    20101 agggcgagcg gcaccttgcc gacgaagccc atcaggagcg tggcgaaggc cgccgcgaac
    20161 gcggtcgcgg tgatcagggc ctgccggccg agcgtgtccc cggccacgtc cttgccggac
    20221 aggatgaggg ggttgaggag gaggatgtac gccatcgcca tgaaggtggt gacaccgccg
    20281 cgcacctcac gcgcgaccga gcttcctcgc agggatatgt gaaagtaccg gtcgagccag
    20341 gaccggccgg ccgcgatacg ggggccttca cccgcgtcgt cggcggcggt ggtcccgggc
    20401 tccactgact gctgggtcat ggtgccgtct cccaaggttc ataggggcac ccgtgcgaaa
    20461 ccgccgtggc ggcacgggct ttgggaaggt gcacgacccg ggggacggcc cgagacgaaa
    20521 cgcggtgctg tacttgtgtt actaccgggt gtcgttggat gcacagtcac ccggtgccgg
    20581 ggttgccgtc gctgtgccca cccgttccgc cctgcggaac gcctgcccac agccacggcg
    20641 gcggttggct acgccgtccc ggtcaggtgt tccgggcgga ccggtgtcct gttgagctcc
    20701 aagcccgtcg cgtcgcggat cgccgcgagg acggccggag tcgacgacag ggtcggggcc
    20761 tcgccgacgc cacggagccc gtacggcgcg tggtcgtcgg cgagttcgag cacgtcgaca
    20821 gggatggtcg gcgtgtcgag gatcgtgggg atgaggtagt cggtgaagga cgggttcctg
    20881 accttcgccg tgacggggtc gacgatgatc tcctccatga ccgccatgcc caggccctgg
    20941 gtcgtgccgc cctggatctg gccgatgacg gacagcgggt tgagcgcctt gccgacatcc
    21001 tgggcgcagg ccagctcgat gaccttcacc aggcccagct cggtgtccac ctcgacgacc
    21061 gcccggtgtg cggcgaacga gtactggacg tgcccgaagc cctgcccggt acggaggtcg
    21121 aagggctcgg tcggccggtg ccgccactc
//
