LOCUS       NZ_AP023440            28081 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces aurantiacus strain JCM 4677 chromosome.
ACCESSION   NZ_AP023440
VERSION     NZ_AP023440.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces aurantiacus
  ORGANISM  Streptomyces aurantiacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 9428393)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014701115.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 05:58:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,211
            CDSs (total)                      :: 8,122
            Genes (coding)                    :: 7,928
            CDSs (with protein)               :: 7,928
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 161 of 194
            Pseudo Genes (internal stop)      :: 17 of 194
            Pseudo Genes (multiple problems)  :: 48 of 194
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:48:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 103109
            Orig. end                         :: 131190
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023440.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017557
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28081
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="nucleoside"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(LipM or LipV or LipU or TunD or pur6 or pur10 or
                     nikJ or nikO or truD)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..28081
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="nucleoside"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20591
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /kind="single"
                     /product="nucleoside"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20591
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10591](+)"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10591
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
     misc_feature    392..407
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     misc_feature    complement(726..741)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            complement(1252..1410)
                     /locus_tag="IGS71_RS00430"
                     /old_locus_tag="GCM10017557_00970"
     CDS             complement(1252..1410)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS00430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_00970"
                     /product="hypothetical protein"
                     /protein_id="WP_190855951.1"
                     /transl_table=11
                     /translation="MQYVPVGASALKVSRLPACYPWWHRVLNATDRPDPAESPYLTEFQ
                     RYALPDA"
     gene            complement(1556..2485)
                     /locus_tag="IGS71_RS00435"
                     /old_locus_tag="GCM10017557_00980"
     CDS             complement(1556..2485)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (15-193). E-value: 5.5e-36.
                     Score: 116.2. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00435_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076732.1"
                     /locus_tag="IGS71_RS00435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_00980"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_190849015.1"
                     /sec_met_domain="ADH_N (E-value: 6.9e-09, bitscore: 34.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.9e-10, bitscore:
                     39.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRAVIYEAFGGPEVLEVREVPEPHAGPGEVRVRVAAAGLNPMDW
                     ILASLPEAAEQFGVTVPSGFGHDFAGVVDEVGVGATGFAVGDRVYGGALSRAVADFVVV
                     KVPAEASEVLSHTPEGISDEVASTLPVAGLTAAAALSAIDLRSGDTVLIGGAAGGVGVF
                     AVQLAKLVGARVIGTASESTFEFLRQLGIEPVAYGAGLADRVRTLAPDGVTAATDLFGT
                     ETAETALALGVPPERISTIAAGSNPPGGVRATGGSEAGPDALARITDAILAGKITVPIA
                     ATFPIEQTHDAVTLQAGRHVHGKIVITL"
     aSDomain        complement(1907..2440)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00435_PKS_ER.1"
                     /evalue="5.50E-36"
                     /label="IGS71_RS00435_PKS_ER.1"
                     /locus_tag="IGS71_RS00435"
                     /protein_end="193"
                     /protein_start="15"
                     /score="116.2"
                     /tool="antismash"
                     /translation="LEVREVPEPHAGPGEVRVRVAAAGLNPMDWILASLPEAAEQFGVT
                     VPSGFGHDFAGVVDEVGVGATGFAVGDRVYGGALSRAVADFVVVKVPAEASEVLSHTPE
                     GISDEVASTLPVAGLTAAAALSAIDLRSGDTVLIGGAAGGVGVFAVQLAKLVGARVIGT
                     ASESTFEFLRQLGIE"
     CDS_motif       complement(1982..2044)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGS71_RS00435_0001"
                     /evalue="6.80E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="IGS71_RS00435"
                     /protein_end="168"
                     /protein_start="147"
                     /score="21.8"
                     /tool="antismash"
                     /translation="GDTVLIGGAAGGVGVFAVQLA"
     gene            complement(2657..3070)
                     /locus_tag="IGS71_RS00440"
                     /old_locus_tag="GCM10017557_00990"
     CDS             complement(2657..3070)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007826886.1"
                     /locus_tag="IGS71_RS00440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_00990"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_079103181.1"
                     /transl_table=11
                     /translation="MMETAQVATAGRLLAHDTFDSKCPLRPIMDQTTSRWATLIVSALV
                     GGPHRFAQLHVRVGGISQKMLSQNLKALARAGLVARHVAPTNPPQVTYSLTELGVSLAG
                     PLTDLIGWFGRHGDELLAAQKDYDSRQAESAAN"
     misc_feature    3077..3090
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.64"
                     /tool="antismash"
     gene            3162..3911
                     /locus_tag="IGS71_RS00445"
                     /old_locus_tag="GCM10017557_01000"
     CDS             3162..3911
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-168). E-value: 1.5e-14. Score:
                     46.2. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00445_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357917.1"
                     /locus_tag="IGS71_RS00445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01000"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_190849016.1"
                     /sec_met_domain="adh_short (E-value: 8.9e-34, bitscore:
                     115.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2e-32, bitscore:
                     112.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSNNARTAIVTGASKGLGAGIAKALAGTGAAVVVNYRVDAEGAE
                     RVVADITAKGGRAIAVQADVAGGDDVRRLFDRAREVYGPVDVLVNNASVVTFAPLSDIT
                     EEEFQREMTTNVLGTILTTQALAAQDDIDAGSIINISTAGTVSHPPYASLYVASKSAVN
                     AFTVITAKELGPRGIRVNAIMPGPSDTEGTRAIGYVGSEQEAQTIAATPLGRTGTPDDY
                     GPLVTFLASDDTRWITGDVILASGGMR"
     aSDomain        3183..3665
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00445_PKS_KR.1"
                     /evalue="1.50E-14"
                     /label="IGS71_RS00445_PKS_KR.1"
                     /locus_tag="IGS71_RS00445"
                     /protein_end="168"
                     /protein_start="7"
                     /score="46.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAIVTGASKGLGAGIAKALAGTGAAVVVNYRVDAEGAERVVADIT
                     AKGGRAIAVQADVAGGDDVRRLFDRAREVYGPVDVLVNNASVVTFAPLSDITEEEFQRE
                     MTTNVLGTILTTQALAAQDDIDAGSIINISTAGTVSHPPYASLYVASKSAVNAFTVI"
     CDS_motif       3189..3266
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGS71_RS00445_0001"
                     /evalue="3.00E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IGS71_RS00445"
                     /protein_end="35"
                     /protein_start="9"
                     /score="10.3"
                     /tool="antismash"
                     /translation="IVTGASKGLGAGIAKALAGTGAAVVV"
     gene            4015..4956
                     /locus_tag="IGS71_RS00450"
                     /old_locus_tag="GCM10017557_01010"
     CDS             4015..4956
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021371.4"
                     /locus_tag="IGS71_RS00450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01010"
                     /product="DUF2071 domain-containing protein"
                     /protein_id="WP_190849017.1"
                     /transl_table=11
                     /translation="MFVFLAVLALVLSVGSAAWIAEHALRRTRRQTRYGRYAPWIHPRG
                     RLAAPLNWVADSRLLRTLCERIPPVAFASDMRDVVYVNYVVDARRIEPLIPPGLELQRI
                     GEAADQAMLTFLSYRHGHLGPASLGRWRRLLPSPLQSNWRVYVHHRRTGALGVHFLSTA
                     IDRTFHALGARMTAEALPMHVLGRASLLTSEDGRIDLLLGPGHGSAPDAEAHLAPLPEW
                     PTDGPWRCAFSDYEQMLAYCVPQDRALSVQPWYGRITRQEISLGIPLDVCVALTGPVHS
                     AAAGAITGDAEPFSFLVPLVKFRFENEEHDPI"
     gene            complement(5040..5594)
                     /locus_tag="IGS71_RS00455"
                     /old_locus_tag="GCM10017557_01020"
     CDS             complement(5040..5594)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075631.1"
                     /locus_tag="IGS71_RS00455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01020"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_190849018.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.4e-08, bitscore:
                     32.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAYVILPGIDGSDEKHWQSLWENEWGASAVRIAPASWSRPDLSD
                     WVAAVQAAYEVASERDDQDDQVVLVAHSLGCWAAAQWLERVRPDGVTAFLVAPPNPQGP
                     AFPRAAASTFLGVSARPLPCPSLMVASDDDPYCDPTASASFAQGWQAQRSFVGSHGHIN
                     SDSGLGDWQAGREFLRTLVDR"
     misc_feature    5553..5567
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            complement(5661..6542)
                     /locus_tag="IGS71_RS00460"
                     /old_locus_tag="GCM10017557_01030"
     CDS             complement(5661..6542)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (26-272). E-value:
                     2.1e-36. Score: 117.7. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00460_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019355002.1"
                     /locus_tag="IGS71_RS00460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01030"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190849019.1"
                     /sec_met_domain="PF00561 (E-value: 2e-27, bitscore: 95.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.4e-17, bitscore:
                     62.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEIRHQYATVRGHRVFYREAGPGDAPTLVLLHGFPTSSRMFRRL
                     IPELADRFHVIAPDHLGFGHSDTPSADTFPYTFDALTDITEELLAGLGVTDYAIYVQDY
                     GAPIGWRLALRNPQSITAVITQNGNAYEDGFVPGFWAPVWAYAKDPGPGTEPAVRGALD
                     LDAVRWQYLHGVDRPELVDPDTWTADHRDISRPGNDLVQLALFRDYATNPPLYPQVHAY
                     FRESRVPLLAVWGAEDQIFGPDGARAFARDLPGAEIHLVPGGGHFLLESHLDGTAGHIR
                     DFLTRTLSATRV"
     aSDomain        complement(5727..6464)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00460_Abhydrolase_1.1"
                     /evalue="2.10E-36"
                     /label="IGS71_RS00460_Abhydrolase_1.1"
                     /locus_tag="IGS71_RS00460"
                     /protein_end="272"
                     /protein_start="26"
                     /score="117.7"
                     /tool="antismash"
                     /translation="PTLVLLHGFPTSSRMFRRLIPELADRFHVIAPDHLGFGHSDTPSA
                     DTFPYTFDALTDITEELLAGLGVTDYAIYVQDYGAPIGWRLALRNPQSITAVITQNGNA
                     YEDGFVPGFWAPVWAYAKDPGPGTEPAVRGALDLDAVRWQYLHGVDRPELVDPDTWTAD
                     HRDISRPGNDLVQLALFRDYATNPPLYPQVHAYFRESRVPLLAVWGAEDQIFGPDGARA
                     FARDLPGAEIHLVPGGGHFLLESH"
     misc_feature    complement(6556..6573)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            6653..7156
                     /locus_tag="IGS71_RS00465"
                     /old_locus_tag="GCM10017557_01040"
     CDS             6653..7156
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718392.1"
                     /locus_tag="IGS71_RS00465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01040"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_190849020.1"
                     /transl_table=11
                     /translation="MIDERALLEALNSTPVVDGRSQDLWADDAELRRWAQEHGGPDDAP
                     AIDWLRTARDVLQTATLGPVPEAELQQMLSGVCRLPEVGESGLRWRLQVPPERMLAVEL
                     VLAWYDVRERRPGRLRPCGNDECRLFLLDRSRANTARWCSMKTCGNRLKARRHQERTRQ
                     APTP"
     gene            7391..7615
                     /locus_tag="IGS71_RS00470"
                     /old_locus_tag="GCM10017557_01050"
     CDS             7391..7615
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS00470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_01050"
                     /product="hypothetical protein"
                     /protein_id="WP_055509072.1"
                     /transl_table=11
                     /translation="MRVRTILAAGAFAVTAILGSAGSALADDHDEHRSEGDFRICGEFA
                     NAGDGHASYGAGCAEGHWKGDGQEGRSSF"
     gene            complement(7853..8239)
                     /locus_tag="IGS71_RS00475"
                     /old_locus_tag="GCM10017557_01060"
     CDS             complement(7853..8239)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638969.1"
                     /locus_tag="IGS71_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01060"
                     /product="hypothetical protein"
                     /protein_id="WP_055509070.1"
                     /transl_table=11
                     /translation="MEDGVYVGNAGKDAALDRGWLLGHFKEPGGPRHSQAVEVKWGVHP
                     RGEQRAQWVKGEVRTALLVLITGRFRMEFPGRSVLLEEQGDYVVWGQGVDHSWVAEDES
                     VVLTVRWPSVAGYAVPQDEERAGS"
     gene            complement(8305..9510)
                     /locus_tag="IGS71_RS00480"
                     /old_locus_tag="GCM10017557_01070"
     CDS             complement(8305..9510)
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000018: Glycosylation (69% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1102: glycosyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175588.1"
                     /locus_tag="IGS71_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01070"
                     /product="glycosyltransferase"
                     /protein_id="WP_190849021.1"
                     /sec_met_domain="MGT (E-value: 7.3e-29, bitscore: 100.1,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLSTYGTRGDVEPLVALTVRLQELGVEVRMCAPPDEEFAERL
                     AGLGVDLVPVGPPVRALMRGASLPSAAELSRYRTEMVEAQFGIFPAAADGCDALVAAGL
                     AQIAARSVAEAAGIRYVYVSYAANSLPSPHHAPPPRPGWPEPEANDNRTLWELDAHQAN
                     AQFSETLNGHRAAIGLPPVDNVRDHVLTDRPWLAADPVLGPWRQTPGLHVTQTGAWSLA
                     DERPLPADLVSFLEAGTPPVYVGFGSLRPSPGIVERAIEALRAQGHRVLVSRGWADLNP
                     VDDRDDCFAIGEVSHQRLFGRVAAVVHHGGAGTTVTAARAGVPQVVVPLQLADNPYWAG
                     RVADLDIGAALDGPTLTTESLDVAFKTALSPETRTRAKDVGSRIRTDGAAVAASLLRDA
                     LR"
     gene            10001..10591
                     /locus_tag="IGS71_RS00485"
                     /old_locus_tag="GCM10017557_01080"
     CDS             10001..10591
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     nucleoside: LipM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_01080"
                     /product="hypothetical protein"
                     /protein_id="WP_220450575.1"
                     /sec_met_domain="LipM (E-value: 9.1e-64, bitscore: 214.1,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDRSLDAVVELTKSGLDVRVVVVFGTHKLDTVSYLARYAETFQM
                     VFVYQDESFEPGLDGAIRSALPMTRGPVALVLPDIVVNGAGSVGSLLAALRHTAVSGWS
                     VVAAEERNPDTLQQMGALAVSESGGLLTVGAAADKPADPSGFNAFWGMVAVTEAEAHRL
                     PDVVSKGVDSPLTGAVALMVEEIVNYNTNTAAG"
     misc_feature    complement(10023..10043)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.08"
                     /tool="antismash"
     gene            complement(10742..11764)
                     /locus_tag="IGS71_RS00490"
                     /old_locus_tag="GCM10017557_01090"
     CDS             complement(10742..11764)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020551534.1"
                     /locus_tag="IGS71_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01090"
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_198427892.1"
                     /sec_met_domain="ADH_N (E-value: 2.4e-22, bitscore: 77.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-19, bitscore:
                     69.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGVVMHTAGDVRVEDRDDPKIIEPTDAVVKLTATCICGSDLWPY
                     RGIEPADHTLMGHEYVGVVEEVGSAVKTVKPGDFVVGSFVISDNTCEICRAGFQSKCVH
                     AEFVHAGIGTQAEKARIPLADGTLVATPGQPDPELIPALLAASDVLGTGWYAAVAAEAG
                     PGKTVAVVGDGAVGLMAVLAAEQLGAERIIAMSRHPERQKLARYYGATDIVEERGEEGV
                     AKIKELTNGLGAHSVIEAVGTQESFMQAVGATRGGGHLGYVGVNYDVTVPGIELFFAGI
                     HTLGGPAPVRRFLPELIQLIWDRRIDPGKVFDLTLPLEQAPEGYKAMDERRATKVLLTL
                     "
     gene            12106..12840
                     /locus_tag="IGS71_RS00495"
                     /old_locus_tag="GCM10017557_01100"
     CDS             12106..12840
                     /NRPS_PKS="Domain: PKS_KR (3-86). E-value: 2.2e-09. Score:
                     29.4. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00495_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544382.1"
                     /locus_tag="IGS71_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01100"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_055509064.1"
                     /transl_table=11
                     /translation="MSRILITGSTDGLGYATADALQSAGHDIVVHARNPQRARALDPLV
                     GRGADLVVADFTDPDAVRHIATELNDGPPLDAVIHNAGVWSGRAVMPVNVVAPYLLTAV
                     LRRPRRLVYLSSGSHFDGRPSLEGIDSADTKPGSYADSKLFVTTLATAMARLYPDVLSN
                     AVDPGWVPTKMGGPGAPDDLELGHRTQQWLASSDDPQALTTGGYWYHRQRQQPHPAAHD
                     EAFQDRLLHTLAKETGTALSAW"
     aSDomain        12115..12363
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00495_PKS_KR.1"
                     /evalue="2.20E-09"
                     /label="IGS71_RS00495_PKS_KR.1"
                     /locus_tag="IGS71_RS00495"
                     /protein_end="86"
                     /protein_start="3"
                     /score="29.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="ILITGSTDGLGYATADALQSAGHDIVVHARNPQRARALDPLVGRG
                     ADLVVADFTDPDAVRHIATELNDGPPLDAVIHNAGVWS"
     gene            complement(12980..13495)
                     /locus_tag="IGS71_RS00500"
                     /old_locus_tag="GCM10017557_01110"
     CDS             complement(12980..13495)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (18-154). E-value:
                     2.9e-15. Score: 48.8. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00500_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022072.4"
                     /locus_tag="IGS71_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01110"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_055509062.1"
                     /transl_table=11
                     /translation="MFEAVNWPQAMVPSRSPIHFTNELEVAASPETVWSLLVDPEAWPS
                     FYPGVEHVQLLDGHDSLRLGTRFETNLAGQDVFASVQEFEPMTRIAWGGYPKAAEASKA
                     YHAWIITPTPNGCHLWTEETMQGPFWIELAKNAPDAFWRTHEQLLAALAKIATERGDRS
                     GASGPVAR"
     aSDomain        complement(13034..13441)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00500_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.90E-15"
                     /label="IGS71_RS00500_Polyketide_cyc2.1"
                     /locus_tag="IGS71_RS00500"
                     /protein_end="154"
                     /protein_start="18"
                     /score="48.8"
                     /tool="antismash"
                     /translation="HFTNELEVAASPETVWSLLVDPEAWPSFYPGVEHVQLLDGHDSLR
                     LGTRFETNLAGQDVFASVQEFEPMTRIAWGGYPKAAEASKAYHAWIITPTPNGCHLWTE
                     ETMQGPFWIELAKNAPDAFWRTHEQLLAALAK"
     gene            complement(13542..14045)
                     /locus_tag="IGS71_RS00505"
                     /old_locus_tag="GCM10017557_01120"
     CDS             complement(13542..14045)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (23-159). E-value:
                     2.9e-15. Score: 48.9. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00505_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019928.4"
                     /locus_tag="IGS71_RS00505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01120"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_055509060.1"
                     /transl_table=11
                     /translation="MYDKVNWPERYDPKTSAIYALNDIDVKAPPEVVWKLLVDAENWSS
                     YFPAEDQVKILSGDPELALGTKYSRVTVGFPMSLSVTEFEPFSRLSWETVVDSDETGSS
                     AYHGWVITPTDDGCHVLTEETQQGLFFLEELGHKHPGALYRYHQDWVERLARAAEAEVA
                     NRPV"
     aSDomain        complement(13569..13976)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00505_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.90E-15"
                     /label="IGS71_RS00505_Polyketide_cyc2.1"
                     /locus_tag="IGS71_RS00505"
                     /protein_end="159"
                     /protein_start="23"
                     /score="48.9"
                     /tool="antismash"
                     /translation="IDVKAPPEVVWKLLVDAENWSSYFPAEDQVKILSGDPELALGTKY
                     SRVTVGFPMSLSVTEFEPFSRLSWETVVDSDETGSSAYHGWVITPTDDGCHVLTEETQQ
                     GLFFLEELGHKHPGALYRYHQDWVERLARAAE"
     gene            complement(14144..14725)
                     /locus_tag="IGS71_RS00510"
                     /old_locus_tag="GCM10017557_01130"
     CDS             complement(14144..14725)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS00510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_01130"
                     /product="dinucleotide-binding protein"
                     /protein_id="WP_198427893.1"
                     /transl_table=11
                     /translation="MPELEMPERRETKMKIVTIGRGMIGGGLAGLWRTAGHDVMGLGRD
                     GGDASDADVVLVAVPGDKISAALSKVTGLGGKTAIDATNIMPARHGDFPSYAEEVKSFT
                     GGPVAKSFNMNFGGLFGVVREQRVRPSNWYVADDGAREVTERLIRDAGYDPVRVGDLSR
                     ARDFENAVWLLMGIQPVGGVFYRFAVPGEL"
     gene            complement(14757..15689)
                     /locus_tag="IGS71_RS00515"
                     /old_locus_tag="GCM10017557_01140"
     CDS             complement(14757..15689)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (5-203). E-value: 1.6e-17.
                     Score: 55.4. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00515_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055481.1"
                     /locus_tag="IGS71_RS00515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01140"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_190849022.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.6e-07, bitscore:
                     27.8, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.1e-15, bitscore:
                     55.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQTFVTGGSGFIGQVLVRRLIDEGHSVRALVRSQASAEKVSALG
                     AEPVRGELTDPTTWRDQVTGSDVVFHLAAATDVTADRERHELVSVRGTQAAVDAARYAQ
                     VPRFVHCGSEAALLAGDPLVDVDETAPLRPDSEAAYCAVKAAAEKIVLDANAPGFATVS
                     IRPRFVWGPDSILTDSLVAAAKAGQFAWIDGGRHTTDVTFVENAVEGLVLGWRRGRPGQ
                     AYFVTDRHRVSLREFLETLFEIHGVDTPIPELDVETAAREVPVPVRWFLGQSCTLRTDK
                     AVAELGYEPVVSHAAGLDAVRNSLAVSGT"
     aSDomain        complement(15081..15674)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00515_NAD_binding_4.1"
                     /evalue="1.60E-17"
                     /label="IGS71_RS00515_NAD_binding_4.1"
                     /locus_tag="IGS71_RS00515"
                     /protein_end="203"
                     /protein_start="5"
                     /score="55.4"
                     /tool="antismash"
                     /translation="VTGGSGFIGQVLVRRLIDEGHSVRALVRSQASAEKVSALGAEPVR
                     GELTDPTTWRDQVTGSDVVFHLAAATDVTADRERHELVSVRGTQAAVDAARYAQVPRFV
                     HCGSEAALLAGDPLVDVDETAPLRPDSEAAYCAVKAAAEKIVLDANAPGFATVSIRPRF
                     VWGPDSILTDSLVAAAKAGQFAWIDGGRHTTDVTF"
     gene            15825..16766
                     /locus_tag="IGS71_RS00520"
                     /old_locus_tag="GCM10017557_01150"
     CDS             15825..16766
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140579.1"
                     /locus_tag="IGS71_RS00520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01150"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_055509053.1"
                     /transl_table=11
                     /translation="MTSLRALECLVAVADSGSITQAALLLHSSQPAVSHQIAALERETR
                     TVLLRREPRGVKLTPAGRAAVADARRAIEAAASAVRSARAAGQAAGGVLRLACAQSLTV
                     ALLAPVIRQWHRRHPEVAITLRESTAMDEILGFLDSDEVDLVLMSTPPPGRFTITAVAE
                     EEIVLAAPTGHPLTEQPAVRIEDLEGAPLVHFAPDNGLSVWLDQSLARAGVHPETVMRT
                     SVTAAAPQLAAAGLGIAVCPVSAVSDGFPGAVRSFSPRWVRQLVAVTSTEPDPLVARFI
                     GNLRTHGVRLPRGVRSRLADDNSASAKTRPAS"
     gene            16972..18177
                     /locus_tag="IGS71_RS00525"
                     /old_locus_tag="GCM10017557_01160"
     CDS             16972..18177
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="IGS71_RS00525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01160"
                     /product="MFS transporter"
                     /protein_id="WP_190849023.1"
                     /transl_table=11
                     /translation="MSSATNEETRVREKARLPLAGLLSLFTAGFLGIINETIPAGLLPE
                     MSKSLGLSESVVGQTVTVYALATALTAIPLNAAMKNLGRRTVLVSALAAFILANTVATF
                     VSSFEVLLVTRFVAGVGAGLIWSNLGGYAARIVPAEFQGKAVAIAMAGTPVALSLGLPA
                     GTFLGDAAGWQATFGVVAVVSVALIVWMFASLPNLPGQAAGGHVPVATILRTPGVRAIL
                     WVVAGFMVAHNILYTYIGPLTVASGVGSQIEWVLLVFGVAALLSIWATGTYVDPHHRRL
                     IVMSTVVLGASAVVLGFVQWNPVVLYLGVTAWGFGFGGSATLFVTAGMRAAGTDGIQSV
                     LVTVFNLSIAAGGVFGGLLLGGLGVSSIPWVALAIVIPTALTISAGRRHAFPHWPQPDR
                     IR"
     cand_cluster    17791..28081
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    17791..28081
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[22790:23081](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      22791..23081
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            complement(18284..18775)
                     /locus_tag="IGS71_RS00530"
                     /old_locus_tag="GCM10017557_01170"
     CDS             complement(18284..18775)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075702.1"
                     /locus_tag="IGS71_RS00530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01170"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190849024.1"
                     /transl_table=11
                     /translation="MSPLSAPTVVSSIASPSDADAFRALNEEWISRLFTLEEEDRAVLG
                     NPFDRIVGPGGDVLLARDTGTGAVVGCVALLAYPDAVFELAKMAVAPVAQGHGIGRQLI
                     AAAIDRVRELGGARLFLGTNSKLGPAVHLYEDAGFVRITCDRLPVADYYARADILMELL
                     "
     gene            18875..19756
                     /locus_tag="IGS71_RS00535"
                     /old_locus_tag="GCM10017557_01180"
     CDS             18875..19756
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075703.1"
                     /locus_tag="IGS71_RS00535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01180"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_190849025.1"
                     /transl_table=11
                     /translation="MDPRIELRHLRYFLAVAEELHFGRAAQRLHIAQPALSQQIKQLEK
                     IVGVELFRRTSRNVRLTDAGATFQPRASDLLSRLAADLDEASRVGRGEAGRLDVAFITS
                     ATSIVSERLRAFSRRRPDVQVKLHGAFTVDVLTALERGTADVGIVRDAEERDGIALFPL
                     TSEPFVGVVPADHPAAKGERLEAAALAADPLILFPRSAGPHAFDVNTQPLRDAGVEVQV
                     AQECSDWHTIILLVAAGLGVTIAPYSVTTLLPAGARRLELDGLPRTSQIFMATRRGDER
                     PLVRAFLTASET"
     misc_feature    complement(18921..18935)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            19979..21214
                     /locus_tag="IGS71_RS00540"
                     /old_locus_tag="GCM10017557_01190"
     CDS             19979..21214
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432943.1"
                     /locus_tag="IGS71_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01190"
                     /product="MFS transporter"
                     /protein_id="WP_190849026.1"
                     /transl_table=11
                     /translation="MPLALLALAVVAFGIGTTEFATMGLLPQIADGVGVSVPQAGNLVS
                     AYALGVVVGAPVLTGIGARIPHKRLLLLLTGLFVVGNAASAVAPNFTLLFAARFLAGLP
                     HGALFGVGAVVASRLVAPERAARAVSKMFLGLTVANIVGVPASTALGQQLGWRSAYWAV
                     AVLGLVALVSLALFVPHQPRGQHSGIRHEMRAMGNKQVAIGLATAVVGFGGFFAVYSYL
                     VPMLTHLTGISDTSTTLVLALYGVGMTVGTLLAGPLTDRALRPTLYAGLIALAAALVTF
                     YFTVHATVPALITITFIGAMGSLITTPVQMLLMAKAKNAPTMAAASNHSAFNLANAGGA
                     WLGGLVISAGWGWAAPNLIGAALAVAGLGLAVTGGLMDRGGPVGPRRSKTVASSMGEPS
                     TATEEGTAPQRT"
     gene            21299..22201
                     /locus_tag="IGS71_RS00545"
                     /old_locus_tag="GCM10017557_01200"
     CDS             21299..22201
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (40-148). E-value:
                     1.7e-23. Score: 75.5. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00545_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006137170.1"
                     /locus_tag="IGS71_RS00545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01200"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190849027.1"
                     /sec_met_domain="PF00561 (E-value: 1.3e-16, bitscore: 59.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8e-17, bitscore:
                     61.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTRTATAPSGATLPGVTHHLADINGTRLHYVSAGTTGSPILLV
                     HGWPETWWAFRKLIPLLAQTHRVFAPDLRGFGDSGNADTEYGEAVTAEDLHHLVEHIGA
                     GPVHLLCQDISGGTGFRFAATHPEDVISFTGVETTLAGFGLESLADVNNFGSWHVGFLG
                     APGIPGMLLPGHERELLADFAFPLMNGTEGSITESDVDEFVRTYARPNAWRGTEGLYRG
                     VFSDNGATRALAESHPLAVPVLTVDGAGHTHTENTFRQVTAGEITAVRLDGVGHLIAQE
                     APEALAATMVEFTGRVDSK"
     aSDomain        21419..21742
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00545_Abhydrolase_1.1"
                     /evalue="1.70E-23"
                     /label="IGS71_RS00545_Abhydrolase_1.1"
                     /locus_tag="IGS71_RS00545"
                     /protein_end="148"
                     /protein_start="40"
                     /score="75.5"
                     /tool="antismash"
                     /translation="PILLVHGWPETWWAFRKLIPLLAQTHRVFAPDLRGFGDSGNADTE
                     YGEAVTAEDLHHLVEHIGAGPVHLLCQDISGGTGFRFAATHPEDVISFTGVETTLAGFG
                     LESL"
     gene            complement(<22332..>22445)
                     /locus_tag="IGS71_RS00550"
                     /pseudo=""
     CDS             complement(<22332..22445)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="IGS71_RS00550"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFVATSGCTWQQVPTASFGPTGATAHRRFTEWSKARVW"
     misc_feature    complement(22753..22768)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     misc_feature    complement(22786..22800)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     gene            22791..23081
                     /locus_tag="IGS71_RS00555"
                     /old_locus_tag="GCM10017557_01210"
     CDS             22791..23081
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01653.1"
                     /locus_tag="IGS71_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01210"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_055509042.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 4e-14, bitscore:
                     51.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIKRSIKLSIAAGALVAGMATPALATTIGVGGGTWDYGVSSSTV
                     RSNYFHQTRCHGSSVEGQYYDSSGNVAANDWARASANAASFGNQAWWRNTC"
     gene            23234..25345
                     /locus_tag="IGS71_RS00560"
                     /old_locus_tag="GCM10017557_01220"
     CDS             23234..25345
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGS71_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017557_01220"
                     /product="hypothetical protein"
                     /protein_id="WP_190849028.1"
                     /transl_table=11
                     /translation="MLHQGIKYVHAAVLAFSAVLAFLFVRGLDEDWVLGHSALVWVSES
                     DHSSSGEQVVRAIESFAAKHGVTVARELPDLRDPHQHRHLYLAAGNPGSDAASWLAKGY
                     PAFGRDYHTDVHPIAEFGQRDPRGFYYVFGSPGAGDALLAMFADLGLRGQVNHPLSVSE
                     LTPVYSDGALFWSFLVVALAAVTLTGASVLLSAKTYGALRLQGKSFAELLLRDLRQLGR
                     FWAIAAGTVTAAALLFLGSYNGLAWLGLYASVTAGIAGLLILVVLAAHAAALALTCRIE
                     VLRALKGELPARLATVCAYLVRAPALLLALSIATTVVLAAQDVLARQDSRDAYAKAGDA
                     TAILLNGSLGPETAEMEVQVGQWLRKADAHGQIIVAGRRELQDIAPGSNLPQGEILIVN
                     ETFLAEQPILDPMGRRYGPAPRDEKARGAGPVRIIVPESLNRYASTVTAEIPGLLSPHD
                     PERIRPTDMKTFRARSGQRVFGYDPGSHTRSTGANPDQDRSMVRNPVLVVVPNGSKYLT
                     DNAYTAFATQGGVVFSDPDDVLDGVKAHKLQTYVKAMSPIGQNAALELRRVVNDFRMQL
                     FNLGMAVAVLLITGVGVCIVYSRKNAQAIFVKHISGWRFAAAHRSVLAGEALLAILLAV
                     WVPFDVWHENQELERYTARGIPAPSSPVQITTLDISLTFGLIAVEVSAVLLALAVFHRR
                     IVKERATEA"
     gene            25391..26074
                     /locus_tag="IGS71_RS00565"
                     /old_locus_tag="GCM10017557_01230"
     CDS             25391..26074
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374867.1"
                     /locus_tag="IGS71_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01230"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_055509038.1"
                     /transl_table=11
                     /translation="MIDIDGLSKSFGARTLWSDVTFSINRGEMLALVGPSGSGKSTLLN
                     CLGLLDAPSAGAIRHEGKDITRFDQRGARRFRRDVLGYLFQNYALIDNATVAANLDVAV
                     RPRRSFRRDSGLTIAQALDRVGLAGREKERVHQLSGGEQQRVALARLMVKEPALVLADE
                     PTGALDHANTTMVVDILRRMSDAGCAIVIATHNDYVRDRCDAIRAMEEDPSRSRSGPLR
                     NPHPQ"
     gene            26248..26745
                     /locus_tag="IGS71_RS00570"
                     /old_locus_tag="GCM10017557_01240"
     CDS             26248..26745
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_function="GO:0016018 - cyclosporin A binding [Evidence
                     IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548312.1"
                     /locus_tag="IGS71_RS00570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01240"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_190849029.1"
                     /transl_table=11
                     /translation="MSTNVFFDITIDGAPAGRIVFKLYDDVVPRTAQNFRELATGQHGF
                     GYEGSGFHRVIPEFMLQGGDFTRGDGTGGKSIYGAKFDDENFKLKHDKPFLLSMANSGP
                     NSNGSQFFITTVLTSWLDGKHVVFGEVVEGQDLVTKIESLGSRSGTTRSKIVIASSGEL
                     KN"
     gene            complement(<26920..27048)
                     /locus_tag="IGS71_RS40855"
                     /pseudo=""
     CDS             complement(<26920..27048)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012334.4"
                     /locus_tag="IGS71_RS40855"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTPITEKGAGGGAIVDVNSVAGLAAAPDLVAYSSSKWALRGLA"
     gene            complement(27032..27922)
                     /locus_tag="IGS71_RS00580"
                     /old_locus_tag="GCM10017557_01250"
     CDS             complement(27032..27922)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (3-118). E-value: 1.2e-07. Score:
                     23.7. Matches aSDomain:
                     nrpspksdomains_IGS71_RS00580_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059460.1"
                     /locus_tag="IGS71_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017557_01250"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_190849030.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.9e-05, bitscore:
                     20.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTWFITGTSSGFGRHLTEQLLARGDRVAATARRPESLDDLAAR
                     YGSRLWRSRLDVTDTTELREVVDRAFAELARIDVVVSNAGYGLFGAAEELTDEQIDRQI
                     ATNLTASIQLARAATGHLRRQGGGRYIQIASIGGQVAFPAMSLYHATKWGIEGFWESAA
                     AELAPFGIGVTLVEPGVSRTNFGAGGSVLGAPLPEYADGPSGQLRAILSGELPPLPAPG
                     DPAKIAAAIIASADRTEAPLRLTLGSDAYALATAALRGRLEALEAGRGLAHSTDADDVT
                     APAPAPAGHADHADH"
     aSDomain        complement(27569..27913)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGS71_RS00580_PKS_KR.1"
                     /evalue="1.20E-07"
                     /label="IGS71_RS00580_PKS_KR.1"
                     /locus_tag="IGS71_RS00580"
                     /protein_end="118"
                     /protein_start="3"
                     /score="23.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TWFITGTSSGFGRHLTEQLLARGDRVAATARRPESLDDLAARYGS
                     RLWRSRLDVTDTTELREVVDRAFAELARIDVVVSNAGYGLFGAAEELTDEQIDRQIATN
                     LTASIQLARAA"
     CDS_motif       complement(27833..27913)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGS71_RS00580_0001"
                     /evalue="4.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IGS71_RS00580"
                     /protein_end="30"
                     /protein_start="3"
                     /score="13.0"
                     /tool="antismash"
                     /translation="TWFITGTSSGFGRHLTEQLLARGDRVA"
     misc_feature    28056..28065
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 acatcgcggc cgagctggag gccgcgaaca aggtcggcga tccggacgcc gacgcattgg
       61 tgtccgacct gatcgacaac cgggaggtcg acggggtcaa cgacctgttc cgcaccatcg
      121 gcaagctgag caagaaccag gactaccacg cgcagctgcc cgagcggctc gccgacttca
      181 tggacaaggc cgcggccgac ccgccgggct ggacgaaggc ggacgtcaag gccgcggagg
      241 gcttcttcga ccaccaccac ggcgaagcgt ccatgctcca gggcaccgtc ggcctcatcg
      301 gcacctacct ctcccccacc ggcgccttca ccctgcgctc caccggccgc ctcggcggcg
      361 tggaagggcc gggccggcgc ctgtcgcagt cctcacggct gtttctcgac atgggcaaca
      421 agggggcgat gacagacggg acactgaagg cgaacgtgac caaggtgcgc ctggtccacg
      481 cctctgtgcg ccagctgcac aagaagagtg gtgagtggga ctatgccaag tggggtgagc
      541 ccgtctcgca gaagtacacc accggcgccg cctgcgtctt ctccacccag atcctccagg
      601 ccctgaagaa cctcggcgtc gacgtctcca gggacgacgc ccacgggttc atctgcgcct
      661 ggcactacgt cacccactac ctcggcacac ccgagaagtg gctcctgccc aagaacgccg
      721 acgccgtcga acaactgtgg aaccaggcac gggagacgga gtggaagaag accgacgacg
      781 gcctcttcat gaccgagcag gccatcaagt tctaccggga cctgctgccg cccggagtca
      841 gtgacgccta catcgccgtc acccgcgtgg gcctcggcga caagtacgcc gacatggcgg
      901 gcgtccccaa gaaccccctc gacctcgccg ccaagcccct cgccgaagga cacaaggtcg
      961 tcagcagcat cggcggcggt ctgttcggcg gagccgccga gaagaccgta ggcgtcaatc
     1021 cctacaagga agtcctcggc actgcctcca ggcacttcaa cgagatcgag aagtacgcga
     1081 tcacccacga ccaggacaac cagccccaga tgcaccagga actgaacgac ggccgctgac
     1141 aggcagccgc cgacagccgc cgacagcagg accggacccg gcgacgtagc cgggcggcgt
     1201 gtcccggcgc tgtatcagtc accccccgcc ggccgcaccg gagctccggg atcaggcgtc
     1261 cgggagtgcg taccgctgga attcggtcag gtagggcgac tcggccggat ccggccggtc
     1321 ggtggcgttg aggacgcggt gccaccacgg gtagcaggcg ggcagccggg agaccttgag
     1381 cgccgacgcg ccgacgggaa cgtactgcat gggttcttcc gacagccctt aggtcaactg
     1441 ccgcccggac gcctctcaag cactcgggtg atgcccgagc gggttcggcg ctgccgagcc
     1501 cgatctcggc ggtcatgtgc ttcccgcatc acgttcagcg cacccgggga cctgctcaca
     1561 gagtgatcac gatcttgccg tggacgtggc gtccggcttg cagggtcacg gcatcgtggg
     1621 tctgctcgat cgggaaggta gcggcgatcg gcacagtgat cttcccggca aggatcgcgt
     1681 cggtgatccg cgccagcgcg tccggccccg cttcgctgcc gcccgtcgcg cgcacgccgc
     1741 cgggagggtt ggaccccgcg gcgatcgtgg agatccgctc gggcggtaca ccgagcgcga
     1801 gcgcggtctc cgctgtctcg gtgccgaaca ggtcggtcgc cgcggtcacg ccgtcggggg
     1861 ccagtgtccg tacccggtcg gccaacccgg cgccgtatgc cacgggctcg atgcccagct
     1921 gccgcaggaa ctcgaacgtg ctctccgagg cggtcccgat cactctggcg ccgacgagtt
     1981 tcgcgagctg tacggcaaac acgcccacac cgccggcggc gccgccgatc aggacggtgt
     2041 cgccggaccg caggtcgatc gccgacagag cggcggccgc ggtcaggccg gccacgggaa
     2101 gcgtgctcgc cacctcgtcg ctgatgccct ccggcgtgtg agacagcacc tcggacgcct
     2161 ccgcgggcac cttgaccacc acgaagtcgg cgacggccct gctcagcgcg cctccgtaga
     2221 cgcggtcgcc caccgcaaaa cccgtggcgc cgacgccgac ctcgtccacc acaccggcga
     2281 agtcgtgccc gaagccggac ggcacggtga cgccgaactg ctccgccgcc tcgggcagcg
     2341 aggcaaggat ccagtccatg gggttcaggc cggctgccgc tacgcggaca cggacctcgc
     2401 ccggaccggc gtgcggctcc gggacctctc gcacctccag cacctcggga cctccgaacg
     2461 cctcatagat gacggctcgg ctcatggcag acctccagca ggcagagtga cgatacttgg
     2521 tcccatcacc gtacacgagt gatgggacca agtgccgtag gccgtcctcg ccgtgcgact
     2581 tccgccggtc gcaccgagga cagccacccg ccgcgcgtgg cgtcgggggg ggggaagtcg
     2641 ccgaggcatc cgctccctag ttcgcagcac tctccgcctg ccggctgtcg tagtccttct
     2701 gcgcggcgag gagttcgtct ccgtgccggc cgaaccatcc gatgaggtcg gtcagcggtc
     2761 cggccaggct gacaccgagc tccgtcaggc tgtaggtgac ctgaggcgga ttggtgggcg
     2821 cgacatggcg ggcgacgagt ccggcccggg ccagcgcctt gaggttctgc gacagcattt
     2881 tctgactgat gccaccgact cgtacatgca gctgcgcgaa acggtgcggg ccgccgacga
     2941 gggccgacac gatgagggtc gcccagcggc ttgtcgtctg gtccatgatc ggcctgagcg
     3001 ggcacttgct gtcgaaggtg tcatgggcca ggagcctgcc ggcggtcgcg acctgcgctg
     3061 tttccatcat gacaggagct tacaaaaaag tacgtacttc ccatcagtaa gtggttttcc
     3121 tacggttgct tccacacgca ccaaccgttc taggagccac tgtgagcagc aacaacgcac
     3181 gtacggcgat cgtcacaggc gcgtcgaagg ggctgggcgc aggcatcgcc aaagcactgg
     3241 ccgggaccgg cgcggccgta gtggtgaact accgagtgga cgcggaaggc gccgagcggg
     3301 tcgtcgcgga catcaccgcc aagggcggcc gggcgatcgc ggtccaggcg gacgtcgccg
     3361 gcggcgacga cgtacgccgg ctcttcgacc gggcgcgcga ggtgtacggc ccggtcgacg
     3421 tgctcgtgaa caacgcgtcc gtcgtcacct tcgcaccgct gtcggacatc accgaggagg
     3481 agttccagcg cgagatgacc acgaacgtgc tgggcacgat cctgaccacg caggccctgg
     3541 ccgcgcagga cgacatcgac gccgggtcga tcatcaacat ctcgacggcc ggcacggtca
     3601 gccaccctcc ctacgcctct ctctacgtcg cgtccaagag cgccgtcaac gccttcaccg
     3661 tcatcacggc caaggaactg ggcccgcgcg gcatccgtgt caacgcgatc atgcccggcc
     3721 cttcggacac cgagggcacc agggccatcg gctatgtcgg gtcggagcag gaggcacaga
     3781 ccatcgccgc gacgcccctg ggccgtacgg gcacccccga cgactacggc ccgctggtga
     3841 ccttcctggc ctccgacgac acgcgctgga tcaccgggga cgtcatcctc gcttccggcg
     3901 gcatgcgctg acgacgcctc gcccggccct ttcctctcct tacggtcctc tccttatagt
     3961 cctcctctta cgtctttacg gaaaaggccc caccgcattt gccatactct cgtgatgttc
     4021 gtattcctcg ccgtgctcgc cctggtcctg tcggtcggct cagcggcctg gatcgccgag
     4081 cacgccctgc gtcgcactcg tcggcagacc cgctacgggc ggtacgcgcc gtggatccac
     4141 ccacggggcc ggctcgctgc tccgctcaac tgggtggctg acagccgact gctgcggaca
     4201 ctgtgcgagc gcattccacc ggtggccttc gccagcgaca tgagggacgt cgtctacgtc
     4261 aactacgtgg tcgacgcccg tcgcatcgag ccactcattc cgcccggcct ggaactgcag
     4321 cgcatcggcg aggccgccga ccaggcgatg ctgactttcc tgagttaccg ccatgggcac
     4381 ctggggccgg cgtcgctcgg ccgctggcgg cgcctgctgc cctcgccgct gcagagcaac
     4441 tggcgcgttt acgtgcacca tcgtcgcacc ggtgccttgg gcgtccactt cctcagcacc
     4501 gccatcgatc gcacgttcca cgccctcggc gcgcgtatga cggccgaggc gctgcccatg
     4561 cacgtccttg ggcgagcgtc gctgctcact tcggaggacg ggcggatcga tcttcttctg
     4621 ggtccggggc acggtagcgc gccggacgcc gaagcccatc tcgccccgct gcccgagtgg
     4681 ccgacggacg gaccttggcg ctgcgccttt tccgactacg agcagatgct ggcctactgc
     4741 gtgcctcagg accgtgcgct gtcggttcag ccgtggtacg gacgaataac ccggcaggag
     4801 atttccctgg ggatccctct cgatgtctgc gtagccctca caggaccggt tcattccgct
     4861 gccgccggcg ccatcacagg cgatgccgaa ccattctctt ttctggtgcc gctggtgaag
     4921 tttcgctttg agaacgaaga gcacgatccg atctgaactt ctgaactgga cacacacgtg
     4981 agctgaacac ttgaattgaa ctggggccgg gccggggctg gtgccggggc tgggacatct
     5041 cagcggtcga cgagcgtgcg caggaattcc cggccggcct gccagtcgcc gaggccgctg
     5101 tcggaattga tgtgtccgtg gcttccgacg aaagaccgtt gcgcctgcca cccctgcgcg
     5161 aacgaggccg aggccgtcgg gtcgcaatag gggtcgtcgt cgctggccac catcaggctc
     5221 gggcacggca aagggcgggc ggacacgccg aggaacgtcg acgcggccgc acgtgggaac
     5281 gccggtccct gggggttggg cggcgccacc aggaacgcgg tgaccccgtc gggccgcacc
     5341 cgctccagcc actgagcggc tgcccagcag ccgaggctgt gcgccaccaa caccacctgg
     5401 tcgtcctggt cgtcgcgctc ggaagccacc tcataggcag cctggaccgc ggcgacccag
     5461 tcactcaggt ccggcctgct ccacgaggcc ggcgcgatcc ggaccgctga ggctccccac
     5521 tcgttctccc acaagctctg ccaatgcttt tcatcggaac cgtcgattcc ggggaggatg
     5581 acgtacgcgg ccatcgcaca ccgcctttcc tgtcgtggcc cccacactcc gtggaaacct
     5641 cggccgaccg actctgcctg tcatacccga gtcgccgaca atgtacgggt caggaagtcc
     5701 cggatgtggc cggccgtgcc gtccaggtgg ctttcgagca ggaagtggcc gcctccgggc
     5761 accaggtgga tctcggcgcc cggcaggtcc cgcgcgaagg cgcgggcgcc gtcggggccg
     5821 aagatctggt cctcggctcc ccataccgcc aggagcggga cgcgactctc gcggaagtac
     5881 gcgtgcacct gcgggtagag gggcgggttg gtggcgtagt cgcggaagag ggcgagctgt
     5941 acgaggtcgt tgccggggcg gctgatgtcg cggtggtcgg ccgtccaggt gtcggggtcg
     6001 accagttcgg ggcggtccac cccgtggagg tactgccagc ggacggcgtc cagatcgagg
     6061 gcgccgcgga ccgccggttc cgtcccgggc cccgggtcct tcgcgtaggc ccacacgggc
     6121 gcccagaacc cggggacgaa gccgtcctcg tacgcgttgc cgttctgggt gatcaccgcg
     6181 gtgatcgact gcgggttgcg cagcgcgagc cgccacccga tgggcgcgcc gtagtcctgt
     6241 acgtagatgg cgtagtcggt gacaccgagc ccggccagga gttcctcggt gatgtcggtg
     6301 agtgcgtcga acgtgtacgg gaacgtgtcg gcggacggag tgtcggagtg gccgaagccg
     6361 aggtggtcgg gggcgatgac gtggaaccgg tcggccagct ccgggatcaa tcggcggaac
     6421 atgcgcgagc tggtggggaa tccgtgcagg agtaccagag tcggcgcgtc gccgggtccg
     6481 gcctcccggt agaagacgcg gtgtccgcgc acggtggcgt actgatggcg aatctcagtc
     6541 atgtctaacc ctctcaatcc gctttgatgg ttacctgcgc cctcagtgga ccggatgtcg
     6601 aggtaacctg tcaaggccat gaacggggtt agatgagggg aggtgggcgg acatgatcga
     6661 cgaacgcgcg ctgcttgagg cgctgaacag caccccggtg gtggacggcc ggtcacagga
     6721 tctgtgggcc gacgacgccg agctgcggcg gtgggctcag gagcatggcg gccccgacga
     6781 cgcgccggcg atcgactggc tgcggacggc gcgggatgtc ctccagaccg ccacgctcgg
     6841 ccccgtgccc gaggcggagc tgcaacagat gctttccggc gtctgccggc tacccgaggt
     6901 cggcgagtcg ggcctacggt ggcgtctcca ggtgccaccc gagcggatgc tcgcggtgga
     6961 gctggtgctc gcctggtacg acgtccggga acgcaggccc ggacgactgc gtccctgcgg
     7021 caacgacgag tgccgcctct tcctcctcga ccgcagccgt gcgaacaccg cccgctggtg
     7081 ctcgatgaag acctgcggca atcgtctgaa ggcccgtcgc caccaggagc gcacgcggca
     7141 ggctccgacg ccctgaccgg tgcacatgat cagctgcaca acccggcaat cagtccgcga
     7201 ccatcactgg cccgtcggcg ggagggcgtc ctgctgcggg agggcgtcct gcgcggcgcc
     7261 cacgtttggg tgatgaatgc tcgccgacgg cacgtcccgc cgtgatgctg ggcgcaaggg
     7321 cggtgagggt gcgcatccgc gcaccggatc tcccgctcat gtgtccatca cctctccatc
     7381 gggagcaacc atgcgtgtgc gtaccatcct tgccgccggc gccttcgccg tcaccgcgat
     7441 cctgggcagc gccggctcgg ccctcgccga cgaccacgac gagcaccgca gcgagggcga
     7501 cttccggatt tgcggcgagt tcgcgaacgc gggcgacggc cacgcctcct acggcgccgg
     7561 ctgcgcggag ggccactgga agggcgatgg ccaagagggc cgctcctcgt tctgacgtgg
     7621 catgagccct ggtactccgc gaccgtccga gcctcggggc gcgtgggctc gtatcgcacg
     7681 acgtggtccc acggctgtgg tcacttgagc gccggtcctc ccgcgaacac cgggagggca
     7741 cggtcatgca tgaggtcccg cggtcatccg ggagtcgacc gggtgaccgc ggggcccttt
     7801 gtgtgcgtgg gggctgtgtg tccgtcatgt gtgggcgagg ccgcaatcgg ctctacgaac
     7861 ccgctcgctc ttcgtcctgt ggtacggcgt atccagcgac agagggccat cgcacggtca
     7921 gtaccaccga ctcgtcctcc gcgacccagg agtgatccac tccctggccc cagacgacgt
     7981 agtcgccttg ttcttccaac agcacgctac gaccggggaa ctccatacgg aagcgacctg
     8041 tgatgagaac caggagggct gtacgcactt cgcccttcac ccactgcgcc cgctgttcgc
     8101 cacgtgggtg gacgccccat ttgacctcca cggcctggct gtggcgagga ccgccgggct
     8161 ccttgaagtg cccgagcagc catccccggt ccagcgccgc gtccttgcct gcgttgccca
     8221 cgtacacgcc gtcttccatg cgcccgaacg ctagcagtgt cggttacggc gtcggtcaca
     8281 gggcgatcag cccttccgcc acgcttaccg gagggcgtcg cgcagcaggc tcgcggccac
     8341 cgccgctccg tcggtacgga tcctgctgcc cacatccttt gcccgcgtcc gggtctcggg
     8401 tgacagggcc gtcttgaacg cgacgtccag ggactcggtg gtcagagtcg gaccgtcgag
     8461 tgccgcaccg atgtccaggt ctgccacccg gccggcccag tacgggttgt ccgccagttg
     8521 aagaggcacc accacttgcg gcacgcccgc ccgggctgcc gtcaccgtcg tgcccgcgcc
     8581 gccgtggtgc accacggcgg ccaccctgcc gaacaggcgc tgatgactga cctcgccgat
     8641 ggcgaagcag tcgtcccggt cgtcgaccgg gttcagatcc gcccagcccc gggagacgag
     8701 tacgcggtgc ccctgtgcgc ggagcgcctc gatggccctt tcgacgatgc ccggcgacgg
     8761 gcgcaggctg ccgaagccca cgtagaccgg cggcgtgccc gcctccagga acgacaccag
     8821 atccgcgggg agcgggcgtt cgtccgccag gctccacgca cccgtctgtg tcacgtgaag
     8881 gccgggggtc tgtcgccaag gtcccaggac cgggtccgcc gccagccacg gccggtcggt
     8941 gaggacgtgg tcgcggacgt tgtccacggg tggcaggccg atcgctgccc ggtggccgtt
     9001 gagcgtctcg ctgaactgcg cattcgcttg atgggcgtcc agctcccaca acgtccggtt
     9061 gtcgttcgcc tccggctccg gccagcccgg ccgtggtggg ggcgcatggt gcggtgacgg
     9121 caggctgttc gccgcgtaac tcacgtacac gtagcggatg cccgcagcct cggccacgga
     9181 ccgcgccgcg atctgcgcca ggccggccgc cacgagcgcg tcacacccgt cggccgccgc
     9241 gggaaagatg ccgaattgtg cctcgaccat ctcggtccgg taccgggaca gttccgccgc
     9301 cgacggcagg ctcgcgccgc gcatcaacgc ccgtaccggt ggcccgaccg gcaccaggtc
     9361 caccccgagt cctgccagcc gctcggcaaa ctcctcgtcc ggcggggcgc acatccgcac
     9421 ctccacgccg agttcctgta gccgcaccgt gagtgccacc agcggttcga catcgccacg
     9481 cgtcccgtat gtggacaaca gcacccgcat tccgcgtcct ctttcgttct gtcttcccat
     9541 acgtttcggc ccgccgtctt cgttgacggc ggtgcgttcg gtgcgttcgg tcttcggcgc
     9601 gttcggtctt cggtgcgttt ggtcgttcgg tgcgttgttc gtagcgcgtg tgcggcagca
     9661 gtgtatgcgc aaccgggcga tgtcggacgg gagttgtgcc tcgcccccag cgcctcgccc
     9721 tctcgcgtgg aaccgtcctc ggtggctacg gtgagcgccg gcgtgcgttc caggccgaag
     9781 ccgacagtgc ggtgtcggcc ttggggcgtg cccgtacccg tgcccgtacc cggcgaagtg
     9841 cgcaaggtcc tcgatctcaa gacaacctga gagccactca atgcatagtt cgtccgcgcc
     9901 cgtccccgat gtttcgatca tcttgccctg cgccggattc ggcacgcgct tcagggctcc
     9961 ctactcgaag gaactgcact gtctggcacc cggggtcact gtgctggacc gcagtctgga
    10021 tgccgtcgtc gaactgacca aaagcggact cgacgtacgc gtggtcgtcg tattcgggac
    10081 acacaagctg gacacggtga gttatctcgc gcgctatgcc gagacctttc aaatggtctt
    10141 cgtctaccag gacgagtcgt tcgaaccggg tctcgacggg gcgattcggt cggccctgcc
    10201 gatgacgcgg gggccggtag ccctcgtact gcctgacatc gttgtcaacg gtgcgggcag
    10261 cgtcggcagc ctgctcgccg cgctacggca cacagcggtg tcggggtgga gcgtggtggc
    10321 cgccgaggaa cggaaccctg acaccctgca gcagatgggc gcgctggccg tgagcgagag
    10381 tggcggcctc ctgacggtcg gggcagccgc cgacaagccg gcggatccgt cgggcttcaa
    10441 cgcgttctgg ggcatggtgg cggtcaccga ggcagaggca caccggttgc ccgacgtggt
    10501 gagcaaaggg gtggacagcc cattgaccgg tgcggtcgct ctcatggtgg aggagatcgt
    10561 caactacaac accaacactg ccgcggggtg actttccggg cgtcgacgaa ctcgtacggg
    10621 gttgtcgccg cgcacactcc cctgggctgt gttcgatccg gcctccggcc ccggccgggc
    10681 ctgccgctga agcgcagtgg cagagcccgg ccaggggcgg ctgtgtgggg gccacggtgc
    10741 gtcagagggt gaggagcacc ttggtggcgc ggcgctcgtc catggccttg taaccctcgg
    10801 gggcctgctc cagagggagc gtgaggtcga agaccttgcc ggggtcgatc ctgcggtccc
    10861 agatgagctg gatcagctcg ggcaggaacc ggcgcaccgg ggccggaccg ccgagggtgt
    10921 ggatgccggc gaagaacagc tcgattccgg ggacggtcac gtcgtagttc acacccacgt
    10981 agcccaggtg tccgccgccg cgggtggcgc cgacggcctg catgaatgac tcctgggtgc
    11041 cgaccgcctc gatgaccgag tgcgcgccga gcccgttcgt gagttccttg atcttcgcga
    11101 cgccttcctc gccgcgctct tcgacgatgt cggtggcgcc gtagtagcgg gccagcttct
    11161 gccgctcggg gtgccgggac atcgcgatga tccgctcggc gcccagttgc tcggcggcga
    11221 ggacggccat gagtccgacc gcgccgtcgc cgacgaccgc gacggtcttg ccggggccgg
    11281 cctctgcggc gacggcggcg taccagccgg tgccgagcac gtcggatgcg gcgaggaggg
    11341 cggggatcag ctcggggtcg ggctgccccg gggtggccac cagggtgccg tcggccagcg
    11401 ggatacgggc cttctcggcc tgggtgccga tccccgcgtg gacgaactcg gcgtgcacgc
    11461 atttggactg gaacccggcc cggcagatct cgcaggtgtt gtcggagatg acgaacgatc
    11521 cgacgacgaa gtccccgggc ttgacggtct tcaccgcgga gccgacctcc tcgaccacgc
    11581 ccacgtactc gtgccccatg agggtgtggt cggcgggctc gatgccgcgg tacggccaca
    11641 ggtccgagcc gcagatgcag gtcgcggtca gcttcacgac ggcgtcggtc ggctcgatga
    11701 tcttcggatc gtcgcggtcc tccacgcgga cgtcaccggc cgtgtgcatc actactccac
    11761 gcatggtggg tctcctcact cggtgtgccg gcgcttcgcg ccggttcgtg tgtcaggaag
    11821 gcacgagatc gccgccgctt cctcggcttg tgcgcccccg accgccgagc ccgctgaata
    11881 ggcgtaatcc gcccggggcg cggccggtgg tgcggcgagt ggggcccctg ctcgaagagc
    11941 ttgggggagg gtgccgggcg tcgcgatgcc gcggagatcc atcagaaggg ccctaagggc
    12001 tgtcccgccc acacgccggt tcccggcaca ctgaaagccg ttcagcacag caattccggg
    12061 caacaacacc ccaaggagtc ctcccgtgca gcacacagga cgatcatgag ccggatcctg
    12121 atcaccggtt ccacggacgg cctcggatac gccacggcgg acgcactgca gtccgccggg
    12181 cacgacatcg tggtccacgc ccgcaacccg cagcgcgcca gggccctcga cccgctcgtc
    12241 ggccgcgggg cggacctcgt cgtcgccgac ttcaccgacc ccgacgccgt acggcacatc
    12301 gccaccgagc tgaacgacgg accaccgctc gacgcggtca tccacaacgc cggcgtctgg
    12361 agcggacggg cggtcatgcc ggtcaacgtc gtcgcgccct acctgctcac cgcagtgctg
    12421 cgccgcccac gccgcctggt gtacctgagc agcggctcgc acttcgacgg ccgcccctca
    12481 ctggagggca tcgactcggc cgacacgaag ccaggttcgt acgcggacag caagctgttc
    12541 gtcaccacgc tcgccaccgc gatggcccgc ctgtaccccg acgtgctgag caacgccgtg
    12601 gatccgggct gggtgcccac caagatgggt gggcccggcg cacccgacga tctcgaactc
    12661 ggccaccgga cacagcagtg gctggcgagc agcgacgatc cccaggcact gaccaccggc
    12721 ggctactggt atcaccgcca gcggcagcag ccgcatcccg ccgcacacga cgaggcgttc
    12781 caggaccggc tcctgcacac gctggccaag gagacaggca ccgcgctcag cgcgtggtga
    12841 cagtacccct cgacagcgtc gtctgcccgg cgcggccttc tcatggcggc agatgcctta
    12901 ccgggcgggc tgaccggctc cgcccgcggc gtgccgtcga tcagcggcac ggcgcgggcg
    12961 agagcgaggg agtgtcggcc taccgcgcaa ccggtcctga tgctccggac ctgtccccgc
    13021 gctcggtcgc gatcttggcg agcgccgcaa ggagttgctc gtgcgtgcgc cagaaagcgt
    13081 caggagcgtt cttcgccaat tcgatccaga acggaccctg catcgtctcc tcggtccaga
    13141 gatgacatcc gttcggcgtg ggcgtgatga tccacgcgtg ataggccttg gacgcttccg
    13201 cggccttggg atacccgccc caggcgatac gcgtcatggg ttcgaattcc tgcacggacg
    13261 cgaagacgtc ctggccggcc agattggttt cgaaccgcgt gccgaggcgc agcgagtcat
    13321 ggccgtcgag cagctggacg tgctcgacgc ccgggtagaa gctgggccag gcctccgggt
    13381 ccacaagcag ggaccagact gtctcgggag atgccgcgac ctccagttcg ttggtgaagt
    13441 ggatcggaga gcggctggga accatggcct gcggccaatt cactgcttcg aacacatcaa
    13501 tctccagatg ttcaatgaaa ccagatgttc aatgaaaggg gtcagaccgg acgattcgct
    13561 acttccgcct ctgcggcgcg ggcgaggcgt tcgacccagt cctggtgata gcggtagagg
    13621 gcgccgggat gcttgtgccc gagttcctca aggaagaaga gtccctgctg cgtttcctcg
    13681 gtcagcacgt gacaaccgtc gtccgtgggt gtgatcaccc agccgtggta cgcgctcgaa
    13741 ccggtttcgt cgctgtcgac caccgtctcc cacgagagcc tgctgaaagg ctcgaactcc
    13801 gtcacgctca ggctcatggg aaaaccgacc gtcacccggc tgtatttggt tccgagcgca
    13861 agttccgggt cgccactcag gatcttcacc tgatcttcgg caggaaagta gctcgaccag
    13921 ttctcggcgt cgacgagcag cttccacacc acttcgggcg gcgccttcac gtcgatgtcg
    13981 ttgagcgcgt agatggccga cgtcttcgga tcgtaccgct cgggccaatt caccttgtcg
    14041 tacatcagtc acttctcttt ctatttcttc ttcaatattc tggagggaac atttcccttg
    14101 cacggaacgc gggtgccggg acccggaagg cgggcgcccg gcctcagagc tcgccgggaa
    14161 cggcgaaccg gtagaacacg ccgccgaccg gctggatgcc catgagcagc cagaccgcgt
    14221 tctcgaaatc gcgggcccgt gagagatccc cgacacgcac ggggtcgtag ccggcgtcac
    14281 ggatgagccg ctcggtgacc tcgcgggcgc cgtcgtccgc gacgtaccaa ttgctcggcc
    14341 gcactcgctg ctcgcgcacg acgccgaaca ggcctccgaa gttcatgttg aagctcttgg
    14401 ccaccgggcc gccggtaaac gacttcacct cctcggcata cgacggaaag tcgccatgcc
    14461 gcgccggcat gatgttcgtc gcgtcgatcg cggtctttcc cccgagcccc gtcaccttgc
    14521 tcagggcagc cgagatcttg tcgccgggaa cggcaaccag gacgacgtcc gcgtccgacg
    14581 cgtccccgcc gtcacgaccg agtcccatta cgtcgtggcc cgcggtgcgc cacaggccgg
    14641 ccagccctcc gccgatcatt cctcttccga tcgtgacgat cttcattttg gtttcccttc
    14701 gttcaggcat ttccagttca ggcatgcaca taggtcggtc gaacggatgc ggagtttcac
    14761 gtgccgctga cagccagcga attcctgaca gcgtccagac cggcggcatg cgagacaacg
    14821 ggctcgtatc ccaactcagc cacggctttg tccgtccgca gggtgcacga ctgcccgagg
    14881 aaccatcgga cgggaacggg gacctcgcga gctgcggtct cgacgtccag ctcggggatc
    14941 ggcgtatcga cgccatggat ctcgaacagc gtctccagga actcgcgcag ggagacgcgg
    15001 tgccgatcag tgacgaagta ggcctggccg ggccggccgc gccgccatcc gaggacgagg
    15061 ccctcgacgg cgttctccac gaacgtgacg tcagtggtgt ggcggcctcc gtcgatccag
    15121 gcgaactggc ccgccttcgc cgccgccacc aggctgtcgg tgaggatgct gtcaggaccc
    15181 cagacgaacc tcgggcgaat cgacaccgtg gcgaaccccg gggcgttcgc gtcgagcacg
    15241 atcttctcgg cagcggcctt caccgcgcag taggcggctt ccgagtccgg ccgcagcggc
    15301 gcggtctcgt cgacgtccac gagggggtcg ccggcgagga gggcagcttc gctcccgcag
    15361 tggacgaacc gaggaacctg cgcgtagcgg gccgcgtcaa ccgctgcctg ggtgccgcgg
    15421 accgacacca gctcgtggcg ttcacggtca gcggtgacat ccgtcgcggc agcgaggtgg
    15481 aacaccacgt cactgcccgt cacctgatcc cgccatgtgg tcgggtcggt caactcccct
    15541 cggacaggct ccgcccccag cgctgacacc ttttcggccg acgcctggct tcggaccaga
    15601 gcacggaccg agtgcccctc gtcgatgagc cgacgtacca gcacctgacc gatgaaccct
    15661 gaaccgcccg tgacgaacgt ctgcgccatg gatctctcct tcgctgagtg cgagcctcct
    15721 cgcctgtctt ggcgagaagg tgtcgttggg ttgtagcaat caggggctcc gaggtcttcc
    15781 ctcgatgaga ttcatgcttc gaagggctgc gataagattt atggatgact tctcttcggg
    15841 cgctggagtg cctcgtcgcg gtggcggact ccgggtcgat cacacaggcc gcgctgctgc
    15901 tgcattcgtc gcaacccgcc gtctcccatc agatcgctgc actggaacgc gagacccgga
    15961 cggtcctgct gcgccgcgaa ccccgggggg tcaagctcac tcccgcaggg cgtgccgccg
    16021 tcgcggatgc cagacgagcg atcgaggcgg ccgcctccgc ggtgaggtcg gcccgtgcgg
    16081 cgggtcaagc ggccggagga gtcctgcggt tggcctgtgc gcagagcctc accgtggcgc
    16141 tgctcgcccc ggtgatccgc cagtggcacc gccgccaccc cgaggtggcg atcactctgc
    16201 gggaatccac ggcgatggac gagatcctcg gcttcctcga ctccgacgag gtcgacctgg
    16261 tgctgatgtc cacccctccg cccgggcgct tcacgatcac cgccgtcgcc gaggaggaga
    16321 tcgtgctggc ggcgcccacc ggtcaccccc tgaccgagca gccggctgtg cgcatcgagg
    16381 acctcgaagg cgcgccactc gttcacttcg caccggacaa cggcctcagc gtctggctcg
    16441 atcagtccct cgcccgcgcc ggagtccacc cggagacggt gatgaggaca tcggtcacgg
    16501 ctgcggcacc acagctcgcg gccgccggtc tgggaatcgc cgtgtgcccg gtgagtgcgg
    16561 tcagcgatgg tttcccgggc gcggtgcgct cgttctcgcc acggtgggtc aggcagctgg
    16621 tggcggtgac gtccacggaa ccggatccgc tcgtcgcacg attcatcggc aatctgcgca
    16681 ctcatggcgt gcgtctgccg cgcggcgtgc gaagccggct cgcggacgac aactccgcgt
    16741 ccgcgaagac gagaccggcc tcctgaggat cgccgcaccg acgcggtcgt tcactcaggt
    16801 cgttcactca ggtcgttcgc cggcggccag cagtggggcg acgccggcac ccatcgaatc
    16861 ggtgaaggtc agacccagaa gaaccgaagg ttgttccagg aatcgccgtg gaagcggtca
    16921 tgttgagccc cggtgtaaac atccattcag ggtttcccgg aaggctcaat catgtcgtcg
    16981 gcgacgaacg aagaaactcg cgtcagagag aaggcaaggc ttcccctggc cggcctcctg
    17041 tcgttgttca cggcgggatt cctgggaatc atcaacgaga caattccggc gggcctgttg
    17101 ccggaaatgt ccaagagtct cggcctttcg gagtccgtcg tcggtcaaac cgtgacggtg
    17161 tacgcgctgg cgacggcact caccgcgatc ccgctcaacg ccgccatgaa gaacctgggg
    17221 cgtcggaccg tactcgtttc ggctctagcc gccttcattc tggcgaacac cgtcgcaact
    17281 ttcgtgagca gcttcgaggt actcctcgtc acgcgcttcg tcgccggcgt cggagcggga
    17341 ctgatctggt cgaacctcgg cgggtacgcg gctcggatcg tccccgccga attccagggc
    17401 aaggcggtcg ccatcgcgat ggcgggcacg cctgtcgcgc tgtcgctcgg tcttccggcg
    17461 ggtaccttcc tgggagacgc cgccggatgg caggcgacct tcggcgtggt ggcggttgtc
    17521 agcgtcgccc tgatcgtctg gatgttcgcc tcgctgccca acctcccggg ccaggccgcg
    17581 ggcgggcatg tgccggtcgc gaccatcctc cggacccctg gggtgcgggc gattctctgg
    17641 gttgtcgccg gattcatggt cgcccacaac atcctgtaca cgtacatcgg tccgctgacg
    17701 gtcgcttcgg gcgtcggcag ccagatcgaa tgggttctcc ttgtatttgg cgtcgcggcc
    17761 cttctcagta tctgggccac gggaacatac gtcgacccgc accaccgccg gctgatcgtc
    17821 atgagtacgg tcgtcctggg tgccagcgct gtcgtcctcg gtttcgtgca gtggaatccc
    17881 gtggtccttt atctgggcgt gaccgcgtgg ggtttcgggt tcggcggttc cgccacgctc
    17941 ttcgtcacgg ccggcatgcg ggcggccggc acggacggca ttcagtcggt cctcgtcacc
    18001 gtcttcaatc tcagcatcgc ggccggaggg gtgttcggcg gcctcctgct gggagggctc
    18061 ggtgtcagct cgattccgtg ggtcgccctc gcgatcgtca ttcctacggc gctcacgatc
    18121 agcgcgggca ggcggcacgc tttcccgcac tggccacagc ccgatcgaat ccgctgacga
    18181 ccccggtcac cctttgctcc tcgccaagcc cctcaagccc gtgaagcccg tgaagcccgc
    18241 caagtgaggg cgcaccatcc gtcgtcggcg gcggcccttg ccgtcacagc agctccatga
    18301 ggatgtccgc acgggcgtag tagtcggcca ccgggagacg gtcgcaggtg atcctgacga
    18361 accccgcgtc ctcgtagagg tggacggccg ggccgagctt gctgttcgtg ccgaggaaca
    18421 gccgggctcc gcccagttca cggacgcggt cgatcgccgc ggcaatgagc tgacggccga
    18481 tgccgtgtcc ctgagcgacg ggggccacgg ccatcttcgc cagttcgaac accgcgtccg
    18541 ggtaggccag aagcgcgacg cacccgacca cagcgccggt gccggtatcc cgagccagga
    18601 gaacgtcgcc gcccgggccc acgatgcggt cgaacggatt tccaaggacg gcccggtcct
    18661 cttcctccaa ggtgaacagg cgcgagatcc attcctcgtt cagcgcccgg aacgcgtcgg
    18721 cgtcgctcgg ggaggcgatc gaagagacca cggtcggggc agagaggggc gacatcaggc
    18781 ggacttcctt tgctgtgcgg cttgcgacca gcctccggcc gggctcaccc atacgtccaa
    18841 tacaaccgat gacctccacc aataagctga acctatggat ccgcgcatcg agctccggca
    18901 tctgcggtac ttcctggctg tggccgagga actccacttc ggtcgggccg cgcagcgact
    18961 gcacatcgct cagccggccc tgtcccagca gatcaagcag cttgagaaga tcgtcggtgt
    19021 cgagctgttc cggcggacct cccgaaatgt ccgcctcacg gacgcgggag cgacgttcca
    19081 gccacgggcc agtgacctgc tgagtcgtct ggcggccgac ctcgacgagg ccagccgtgt
    19141 cggccggggc gaagcaggcc gcctggatgt cgccttcatc acctcggcga cctcgatcgt
    19201 gagcgaacgg ctccgtgctt tctcacgccg ccgtccggat gtccaggtca agcttcatgg
    19261 cgccttcacc gttgacgttc tgacggccct ggagcgaggc acggccgatg tcgggatcgt
    19321 ccgggacgcc gaggagcgcg acggaatcgc ccttttcccc ctgacatcag aaccgttcgt
    19381 gggcgtcgtt ccggcagatc accccgccgc gaagggcgag cgcctggagg cagcggcgct
    19441 ggcagccgat ccgctcatcc tgttcccgcg gtcggcggga ccgcatgcgt tcgacgtgaa
    19501 cacgcagccg ctacgggacg caggggtcga ggtccaggtc gcccaggagt gctcggactg
    19561 gcacaccatc atcctgctcg tcgctgccgg gctcggcgtc accatcgcgc cctacagcgt
    19621 caccacactg ctccccgcgg gcgcccgaag actcgaactc gacgggctcc ctcggacgag
    19681 ccagatcttc atggccaccc gccgaggaga cgaacgtccc ctcgtacgcg ccttcctcac
    19741 agcatccgag acgtgaccga ccctggcaac ggccgaacga cgacaccccg ctgatcctct
    19801 cttgacagtc gcggtggctc ggcccgtccg tcctcgctgc cgcctctgga taggcttgcc
    19861 ctgttctggg gctgccgggc aatggtgctc agcgcgacgg gccagggctg gacatcttcc
    19921 ccggcccgac ctcgcctccc attgaccgga tcaccgtcct tgaaaggtct ctcgcaccat
    19981 gcccctggca ctgctggccc tggccgtcgt cgcgttcggt atcggcacca ccgagttcgc
    20041 caccatgggg ctgctccccc agatcgccga cggggtcggg gtgtccgtac cccaggccgg
    20101 aaacctcgtc tccgcctacg ctctcggggt cgttgtcggt gcccccgttc tgaccggcat
    20161 cggtgcgcgc ataccccaca agcggctgct gctgctcctg accgggctgt tcgtggtcgg
    20221 caacgccgcg tccgcggtcg cccccaactt caccctgctc ttcgccgcac gcttccttgc
    20281 gggcctgccg cacggagcgc tgttcggcgt gggggcggtc gtcgcctccc ggctggtcgc
    20341 tcccgagcgg gcggcacgcg ccgtctcgaa gatgttcctc gggctgaccg tcgcgaacat
    20401 cgtcggcgta cctgccagca cagccctcgg acagcagctc ggctggcgct ccgcctactg
    20461 ggcggtcgcc gtcctcggcc tcgtcgccct cgtctcgctg gccctcttcg ttcctcacca
    20521 gccacgcggg cagcactccg gcatccggca cgagatgcgg gccatgggca acaagcaggt
    20581 ggcgatcggg ctggccacgg ccgtcgtcgg gttcggcggt ttcttcgccg tctacagcta
    20641 cctggtgccc atgctgacgc acctgacggg catctccgac acctcgacca ccctggtcct
    20701 cgcgctctac ggcgtcggca tgaccgtcgg cacgctgctc gcaggtccgc tcaccgaccg
    20761 cgccctgcgg ccgacgctgt acgcggggct catcgcgctg gccgcggcgc tggtgacgtt
    20821 ctacttcacc gtccacgcca ccgtgcccgc cctgatcacg atcaccttca tcggagcgat
    20881 gggctccctc atcaccacgc ccgtccagat gctcctcatg gccaaggcga agaacgctcc
    20941 gaccatggcg gcggcctcca accactcggc tttcaacctg gcgaacgccg gcggcgcctg
    21001 gctcggcggc ctggtcatct cggcaggatg gggctgggcc gcacccaacc tgatcggcgc
    21061 ggcgcttgcc gtggcaggcc tcggcctcgc cgtcacaggc ggcctcatgg accgaggtgg
    21121 tcccgttggt ccccgtcgtt ccaagacggt cgcttcgtcc atgggagaac cctcgacagc
    21181 aaccgaagag ggcacagcgc cgcagcgcac gtgacctcgg aggcgtgacc cgtttgacaa
    21241 ggacaacctg gttgcctact tttatggaca accaggttgc ctacttcggg agcttctcgt
    21301 gaccacgacc aggaccgcaa ccgcgccctc cggcgcgacc cttccgggcg tcacgcacca
    21361 cctcgcggac atcaacggaa cgcgactgca ctacgtctcc gccggcacca ccggctcccc
    21421 gatcctgctg gtgcacgggt ggccggagac gtggtgggcg ttccgcaagc tgattccgct
    21481 gctcgcacag acccaccggg tcttcgcccc cgacctccgc gggttcggcg actccggcaa
    21541 cgccgacacc gagtacggcg aggcggtcac cgccgaggac ctgcaccatc tcgtcgagca
    21601 catcggtgcg ggccctgttc acctcctctg ccaggacatc agcggcggca caggtttccg
    21661 cttcgcggca acacatcccg aggacgtcat cagcttcacc ggagtcgaga cgacactggc
    21721 cggtttcggc cttgagtctc ttgccgacgt gaacaacttc gggtcctggc atgtcgggtt
    21781 cctcggtgct ccgggcatcc ccggaatgct tcttcccggc catgagcgcg aactcctggc
    21841 cgacttcgcc ttccctctga tgaacgggac agagggctcc atcaccgaaa gtgatgtcga
    21901 cgagttcgtc cggacctacg cgcgtccgaa cgcctggcga ggcacggagg gcctctatcg
    21961 aggagtgttc tcggacaacg gcgcgaccag ggctctggcc gagtcgcacc cgctcgccgt
    22021 accggtgctc accgtcgacg gtgccggcca tacccatacc gagaacacct tccgtcaggt
    22081 gaccgccggt gagatcaccg cggtgcgtct tgacggagtc ggccacctca tcgcccagga
    22141 agctcctgaa gcactcgcgg ccacgatggt ggagttcacc gggcgggtcg acagcaaata
    22201 gaagtcatct cattggtgag tctgcggtag cagatcaggg tgcaagcacg ttcgtagcgg
    22261 cggagcaggc gtcgacatcc ggcgagcgtg gatctttgat ccgcacttgc cccggtctac
    22321 aggattcaga cccacacccg ggctttcgac cactccgtga aacgccggtg agccgtcgct
    22381 ccggtcggcc cgaacgacgc ggtcggcacc tgctgccacg tacagcccga ggtcgccaca
    22441 aatatgaaaa cgcatcgatc atcgccgcga actgtccggg acatgggcaa atacgcaggt
    22501 cggacaccta atcctgtccc ggacagcgca acccccttcc ccaccggtgc cacagccgct
    22561 gaactcggtc atgcaaacgc cggggagccc accgcacccc ggcacggtgg gacacataac
    22621 gacccgagtg aaccgggtcg tacgaaacgt cagtggcgct ttggctgcat caattcacca
    22681 gtttgggctc ctactcaggc tggggtgatg aggggcaatg caagtcgccg ctcccagatg
    22741 cacccgttag tgagttcgcc aaaggcttct gacagaagag ggagttgaaa gtgcagatca
    22801 agcgcagcat caagctttcg atcgcggccg gtgcccttgt cgccgggatg gccaccccag
    22861 cgttggccac cacaatcggt gtgggtggtg gcacctggga ctacggcgtg agctccagca
    22921 ccgtgcgctc gaactacttc caccaaacca ggtgccacgg ttcctcggtt gaaggtcagt
    22981 actacgactc aagcggcaac gtggcggcaa acgactgggc cagggccagc gccaacgcag
    23041 cgtcgttcgg taaccaggcg tggtggcgga acacctgctg agctgacgag gaacattcgc
    23101 ggctccgtgt ttctcagaaa gtgtttccag ctgttgggga gcgggtttct ccgctcccca
    23161 acagctcgtt gccggcactt cactcagtct cacgagatgc gctcttcgag cgccctggat
    23221 tttgggatga ttgatgctgc accaaggtat taagtacgtc catgccgccg tgctggcctt
    23281 ttctgcggtg ttggcgtttc tgttcgtgcg agggctggat gaggactggg tgctgggtca
    23341 ctctgctctg gtctgggtgt cagagtccga ccactcgtcg agcggcgagc aggtcgtgcg
    23401 ggcgatcgag tcgttcgcag ccaagcacgg ggtgactgtg gcccgtgagc tgcccgatct
    23461 cagggatccg caccagcatc gacatctcta tctcgccgca ggcaacccgg gctctgacgc
    23521 ggcgtcgtgg ctggcgaagg ggtatccggc gttcggcagg gactaccaca cggacgtcca
    23581 cccgatcgcc gagttcggac agcgggatcc ccggggtttc tactatgtgt tcgggtcacc
    23641 cggggccgga gacgcgctgc tggccatgtt tgccgatctc ggcctgcgcg ggcaggtgaa
    23701 ccatcccctg tcggtctccg agctgacccc ggtctattca gacggtgccc tgttctggtc
    23761 cttcctggtg gtcgctctcg ctgcggtcac gctgaccggt gccagtgtgc ttctcagcgc
    23821 gaagacgtac ggggcactgc ggctccaggg gaagtcattc gctgagctcc ttctccgaga
    23881 tcttcggcaa ctggggaggt tctgggcgat cgcggccggt acggtgaccg cggcagcgtt
    23941 gctcttcctc ggctcctata acggcctggc gtggttgggt ctctatgctt cggtgaccgc
    24001 gggcatcgcc gggctgctca ttctggtggt gttggctgcc catgcggccg cgctcgcgct
    24061 gacttgcaga attgaagtgc tgcgtgccct caagggagaa ctgcccgccc ggctggcgac
    24121 tgtctgcgcc tacctggtgc gtgcccccgc actgctgctt gccctcagca tcgccacgac
    24181 cgtcgtcctg gcagctcagg acgtactggc gcggcaggac agccgggatg cctacgccaa
    24241 ggcgggcgac gccacagcca tcctgctcaa cggcagcctg ggccccgaga cggcggagat
    24301 ggaagtacag gtggggcagt ggctgcgcaa ggccgacgca cacgggcaga tcatcgtcgc
    24361 cggacgccgg gagctccagg acatcgcccc gggctcgaac ctgcctcagg gcgagatact
    24421 catcgtcaac gagacattcc tcgccgagca gccgatcctc gaccccatgg gaaggcgcta
    24481 tggcccggcg ccacgggatg agaaggcccg aggcgccggc ccggtgcgga tcatcgtccc
    24541 cgaatccctc aaccgctatg cgtcgaccgt cactgcggag attcccgggc tgctgagccc
    24601 acacgatccg gaacgcatcc ggccgaccga tatgaagaca ttccgggcga ggagcggaca
    24661 gcgtgtcttt ggctacgacc cggggagcca cacccgcagc actggcgcca acccggacca
    24721 ggaccggtcg atggttcgca atccggtcct ggtcgtcgtc ccaaatggct cgaaatacct
    24781 cacagacaac gcttacaccg cgtttgccac ccagggggga gtggttttct ccgaccctga
    24841 cgacgtcttg gacggcgtca aagctcacaa gctacaaacc tatgtgaaag ccatgagtcc
    24901 gatcgggcaa aacgcggcct tggaactgcg gagggtcgtc aacgacttcc ggatgcagct
    24961 gttcaacctc ggcatggccg tggccgtgct cctcatcaca ggtgtcggcg tctgcatcgt
    25021 ctactcgcgc aagaacgccc aggcaatctt cgtcaagcac atcagcggct ggaggttcgc
    25081 cgccgcccac cgctccgtgc tcgccggcga ggcacttctc gccatcctcc tcgctgtgtg
    25141 ggtcccgttc gacgtgtggc acgagaacca ggagctggag aggtacacgg cccgcggcat
    25201 cccagctccc agcagccctg tccagatcac cacgctggac atcagcctca ccttcgggct
    25261 gatcgccgtt gaggtcagcg cggtgctctt ggccctggcg gtcttccacc gccgcatcgt
    25321 caaggaaagg gcgaccgaag catgagcccc gcccacaccc ggccccttcg actccaacag
    25381 gagcaccgta gtgatcgata ttgacgggct gtcgaagtcc ttcggcgctc ggaccctgtg
    25441 gtccgatgtg accttctcca tcaaccgcgg cgagatgctc gccctcgtcg gccccagcgg
    25501 atcgggcaag tccaccctcc tcaattgcct cggtctcctt gacgcgccga gtgccggagc
    25561 gatccgtcat gagggaaagg acatcacccg attcgaccag cgtggagcca ggcgcttccg
    25621 ccgcgacgtt ctcggttacc tcttccagaa ctacgccctg atcgacaacg ccaccgtcgc
    25681 cgccaatctg gatgtcgccg tcaggccacg ccggtcgttc cggcgcgact caggtctcac
    25741 catcgcccaa gccctcgacc gtgtcggcct cgcggggcgg gagaaggaga gggtccacca
    25801 acttagtggc ggagagcagc agcgtgttgc cctggcccgg ctcatggtca aggagccggc
    25861 cctcgtgctg gccgacgagc ccaccggtgc cctggaccac gccaacacca ctatggtggt
    25921 cgacatcctg cgcaggatga gtgacgccgg atgcgccatc gtcatcgcga cccacaacga
    25981 ttacgtccgc gaccgatgcg acgccatccg cgccatggaa gaagacccga gccgatcacg
    26041 gagtgggccg ctgcgtaatc cccacccgca ataaccgaaa agatgccctt gcccacttgg
    26101 cggcgggctg ctccatcact ctccgctaca catctgtctg ccgtagccat acgagaaccg
    26161 ggccgagccc accgagcacg gcacgtcctg acgctgccgc gcagggcggc tcccgggcat
    26221 gacgcggggc cgtgacaaga tctcctcatg tctaccaacg tcttcttcga catcaccatc
    26281 gacggcgccc ccgcgggccg gatcgtcttc aagctgtacg acgacgtcgt ccccaggacg
    26341 gcgcagaact tccgtgagct ggccaccggc cagcacggct tcgggtacga gggctcgggc
    26401 ttccaccgtg tcatcccgga gttcatgctc cagggcggcg acttcacccg tggcgacggc
    26461 accggcggca agagcatcta cggcgcgaag ttcgacgacg agaacttcaa gctcaagcac
    26521 gacaagccgt tcctgctgtc catggcgaac tccggaccca acagcaacgg ctcgcagttc
    26581 ttcatcacca cggtgctcac gtcgtggctg gacggcaagc acgtggtctt cggcgaggtc
    26641 gtcgagggcc aggacctggt gacgaagatc gagtccctgg gttcgcgttc cggcaccacc
    26701 cgctcgaaga tcgtgatcgc ttcctcgggc gagctgaaga actagcgctt ccgccccggg
    26761 cgacaggccg gttccacgcg ggcccctcca gccgcgtata cgcccgctcg gccgcccggg
    26821 gcctccccca gcccgacgca ccccgccccc ggggacactc gcccttgccg catcgttcgg
    26881 ctccgcggcg gcccggtggc ggggtgctgc cgatctgtcc gcaaggccgc gcagtgccca
    26941 cttgctgctg ctgtaggcga caaggtccgg ggctgccgcc agaccggcga cggagttgac
    27001 gtcgacgatc gcgccaccgc cggccccctt ttcagtgatc ggcgtgatcg gcgtggccgg
    27061 ccggggcggg ggcgggggcg gtgacgtcgt cggcgtcggt ggagtgggcg aggcctcggc
    27121 cggcttcgag ggcttcgagg cggccacgca gggcggcggt ggccagcgcg tacgcgtcgg
    27181 agcccagcgt caggcgcaac ggcgcttcgg tccggtcggc ggaggcgatg atggctgccg
    27241 cgatcttcgc ggggtcaccg ggtgcgggca gcgggggcag ttcgccggag agaatggcgc
    27301 gcagctgtcc tgacgggccg tcggcgtact cgggcagggg cgcgcccagg accgagccgc
    27361 ctgcgccgaa gttggtgcgg gagacgccgg gctcgacgag ggtcacgccg atgccgaacg
    27421 gcgcgagttc ggcggcggcc gactcccaga atccttcgat gccccacttg gtggcgtggt
    27481 agaggctcat cgcggggaag gcgacctggc cgccgatgct cgcgatctgg atgtaccgtc
    27541 cgccgccctg gcggcgcagg tgcccggtgg cggcgcgggc gagctggatc gatgccgtga
    27601 ggttggtcgc gatctgccgg tcgatctgct cgtcggtgag ttcttcggcg gctccgaaca
    27661 gtccgtagcc ggcattggac acgacgacgt cgatccgggc gagctcggcg aacgcgcggt
    27721 ccacgacctc gcgcagctcg gtcgtgtcgg tgacgtccag gcgggaacgc cacagtcggc
    27781 tgccgtagcg ggccgccagg tcgtcgaggc tctccgggcg tcgcgcggtg gcggcgaccc
    27841 ggtcccctcg tgcgagcagc tgctcggtga ggtgacggcc gaagccggag gacgtgccgg
    27901 tgatgaacca agtgcgcgtc atggtgtgct cctaaggatg gggtaactaa ctggttatat
    27961 tcatacccca ccctcaccct caacgtaaac atctggatag ttatgtacga tgagcgcatg
    28021 ccacctgacg ccaccgagac caaacgacgc ctcatgaagg cggccgtcga ggagttcgcc
    28081 g
//
