LOCUS       NZ_CP061172            27007 bp    DNA     circular CON 03-NOV-2023
DEFINITION  Paenibacillus peoriae strain ZF390 chromosome, complete genome.
ACCESSION   NZ_CP061172
VERSION     NZ_CP061172.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus peoriae
  ORGANISM  Paenibacillus peoriae
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6193667)
  AUTHORS   Li,L., Zhao,Y., Li,B. and Xie,X.
  TITLE     Characterization of Paenibacillus peoriae strain ZF390 with
            broad-spectrum antimicrobial activity as a potential biocontrol
            agent
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6193667)
  AUTHORS   Li,L., Zhao,Y., Li,B. and Xie,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-SEP-2020) Institute of Vegetables and Flowers, Chinese
            Academy of Agricultural Sciences, No.12 Zhongguancun South
            St.,Haidian District, Beijing 100081, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-AUG-2020
            Assembly Method                   :: SMRT Link v. 5.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 268.55x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/03/2023 05:03:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,889
            CDSs (total)                      :: 5,744
            Genes (coding)                    :: 5,637
            CDSs (with protein)               :: 5,637
            Genes (RNA)                       :: 145
            rRNAs                             :: 13, 14, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 13, 14, 13 (5S, 16S, 23S)
            tRNAs                             :: 101
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 107
            CDSs (without protein)            :: 107
            Pseudo Genes (ambiguous residues) :: 0 of 107
            Pseudo Genes (frameshifted)       :: 48 of 107
            Pseudo Genes (incomplete)         :: 73 of 107
            Pseudo Genes (internal stop)      :: 18 of 107
            Pseudo Genes (multiple problems)  :: 28 of 107
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:36:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1620878
            Orig. end                         :: 1647885
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP061172.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27007
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27007
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27007
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17007]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17007
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(1191..1209)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 25.22"
                     /tool="antismash"
     gene            1687..2868
                     /locus_tag="IAQ67_RS07435"
                     /old_locus_tag="IAQ67_07435"
     CDS             1687..2868
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820485.1"
                     /locus_tag="IAQ67_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07435"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_190298920.1"
                     /transl_table=11
                     /translation="MIKKNIDSYRQKNGSSHREDSRTRVFRQKATGVLMTGLIAGGLLS
                     GCGMKSAGETNPAFGMKPGQQLTVIDTDTAQKQVTDELVVSSIDRLGDVYARSWLSDEE
                     LIVERQTRLLIHNVKTGKERILTPGRKAPQLLAVVSPDQRHVFFTEGSTSSKYDIQGYI
                     LELSSGKVTSIGKLDMTNEVSWSDENDLITGRPDGKIQLIGLDDKAEELSFQDPNRSEL
                     ISHVEKVGNTIFYTGSDKRGYPVLNRFTLNHPQAITIAEGAMSFAVSPDGKSIAIEKRK
                     WNTSEPARMIILDEQGKEKGIVGQGTLMSRGSWSSDGSKLAFSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSPSARFLSMYQNISEGGKQLNQSYIVEFKRK"
     gene            complement(2938..4380)
                     /locus_tag="IAQ67_RS07440"
                     /old_locus_tag="IAQ67_07440"
     CDS             complement(2938..4380)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="IAQ67_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07440"
                     /product="SpoVR family protein"
                     /protein_id="WP_134902764.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIADGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLEGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATADRINSYEMEYGSKAVESFIDSVLAIQEHVDP
                     QIIKPRHLDKQRYMELKIREQKEPGKRQRPPGPYDDLWSLDKVKQHDPAETEGIKIRQF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGEETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKMFEVREFDSDTSFIRNYMTKKLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TLIEGKLALFSYDGKKHHRKFV"
     gene            complement(4377..5543)
                     /gene="yhbH"
                     /locus_tag="IAQ67_RS07445"
                     /old_locus_tag="IAQ67_07445"
     CDS             complement(4377..5543)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="IAQ67_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07445"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_134902763.1"
                     /transl_table=11
                     /translation="MPEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPNLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGKPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSSYNIYPFHFSDGDNLTSDNERCVKLIEELIKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKKDQFMYYVIKEKGEVYQALRTFFRKQEGGSVG"
     gene            5708..6427
                     /locus_tag="IAQ67_RS07450"
                     /old_locus_tag="IAQ67_07450"
     CDS             5708..6427
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="IAQ67_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07450"
                     /product="response regulator transcription factor"
                     /protein_id="WP_134902762.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTTVLKKEGFLQVKHAATGREALQVVM
                     ESQMDVIVLDVMLPDSDGFEVCRQMRLYTDAPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVVARMKARMKYRKVPTVAMKPALRTLDFGYFRLELEAGVLYVEDKQVECPARE
                     WLLLVFLCKHPNRIFSVRQLYEAIWSEAFLGDEKTVVIHISRLRKKIEPDPKHPQFLIN
                     VRGLGYKMMSVKMGEQE"
     gene            6424..7494
                     /locus_tag="IAQ67_RS07455"
                     /old_locus_tag="IAQ67_07455"
     CDS             6424..7494
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="IAQ67_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07455"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_190298921.1"
                     /transl_table=11
                     /translation="MNSLVKMSFRFMKVTLCFVLAYVLCFVICTIFYIFIKSIFGASQN
                     INIDLFWTGLGIVQSVVFIAAYGWYIGKPLVYVIKWIGNIATGEFQAPLSELELPEGKK
                     NQKNSYKPPYQLYKEVFEQMNILSAQLRSNEEERVEIEKRKQQWVAGVSHDLKTPLSYI
                     EGYAAMLTAQEYDWSDEERRSFSMSISEKVTEMKQLIQDLNASMQLKESPLPIQLEKED
                     IVEFLRSAVIDIANHPSAEQYEFSFTSMEAACIMPFDSKLLGRALQNFLINAIIHNPPG
                     THVSMKVNKANDKLHISIEDDGIGMNSNKFMQVPHSQGHGIPIAKSFIEAHNGTLHILP
                     GSKAGTRMEISLPLNI"
     gene            7624..8547
                     /locus_tag="IAQ67_RS07460"
                     /old_locus_tag="IAQ67_07460"
     CDS             7624..8547
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="IAQ67_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07460"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190298922.1"
                     /transl_table=11
                     /translation="MSEYVIHTQQLTRRFGKREFVKRINLQVPGQQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGEIEIFGKKLKDQRMEILKDVGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRRIHEVLDLVRLTKDAYRPVKGYSLGMRQRLGIAMALIANPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPGAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTA
                     KSKPQLFIETPDPVLAAGALIQHGWTAGAESIEQNEVVTPIVDRQQSSEMIKVLVEHNH
                     PIYRVTEKKKTLEEIFLELTGKERSL"
     gene            8544..9251
                     /locus_tag="IAQ67_RS07465"
                     /old_locus_tag="IAQ67_07465"
     CDS             8544..9251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="IAQ67_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07465"
                     /product="ABC transporter permease"
                     /protein_id="WP_134903595.1"
                     /transl_table=11
                     /translation="MILRVIKAEGLKLKKICWWIPLIQGCVLTGMTAVEWYLYFRQGPG
                     GVYAGFAVMFMFLSFVMLLGGTLLASIMAGTEHDTQTWKQLMAMPVPRSHIYLSKIVWI
                     VILQLGTALITVAGMSLIWVLYTNEPIPWRIMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKILPWSYPALSSPLMKEHMIWVIVALSAGVIFT
                     GLGTLQFTKHEFK"
     gene            9266..10000
                     /locus_tag="IAQ67_RS07470"
                     /old_locus_tag="IAQ67_07470"
     CDS             9266..10000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="IAQ67_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07470"
                     /product="ABC transporter permease"
                     /protein_id="WP_039269799.1"
                     /transl_table=11
                     /translation="MGSILRVETIKLQWIMVWILIILDAVINSLMGVLELNDLKQFFSP
                     SWLTLYTYSAQFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQQIYYAKYIL
                     LILILGLDQLIFIVGYFVSGNIAGAPGEIPWSVVLSTGLGGWLGIFPLAALQLMLSIKI
                     RNFGASLGMSICCVVPNIVITGFHSSIGAWFPFTIPYYIMMPQTASYAPRVEPYSLGLI
                     VIFTFLAYLYGGRKMFVNRDWL"
     gene            complement(10001..11362)
                     /locus_tag="IAQ67_RS07475"
                     /old_locus_tag="IAQ67_07475"
     CDS             complement(10001..11362)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="IAQ67_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07475"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_190298923.1"
                     /sec_met_domain="LANC_like (E-value: 3.9e-55, bitscore:
                     185.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDSFVIQQSDQVRARDISKKIALRLCEPESVYSAVHSEHNVSP
                     ETKYHPWGETSLSHGYPGNIHLLSQWRATDLSYDWNRAIHLNMAQIQSSLAINGLHDLS
                     LYSGWAGIAASVREASNYGEYYSNFSQQIHQWMMPLTEQWLQSNTEQLSLHEGMPMQSF
                     DTISGASGIGRYILINSTNPICTPLVEPILQFLTDLTHPIHIHNHYVPGWYSPQKFQFL
                     DRDKRNYPLGNFNCGMAHGIPGPLALLSVAYSSGIEVKGQYQAIETITEWLLKYKYEDE
                     YGSYWPHIVPFEAETGSLRFDLERAREAWCYGTPGITCSLFLAGKALHNVELQKSAVKA
                     CVGAISYEIAKREMDSSALCHGLAGLLTISWRMWRHSKEPAFLPLIQQLTNSLLDRFQM
                     DSPLGYLDPEPRSDGSLTWLTKAGMLEGVAGIAAALLSVSENKEIGWDYILMLS"
     gene            11560..11712
                     /locus_tag="IAQ67_RS07480"
                     /old_locus_tag="IAQ67_07480"
     CDS             11560..11712
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="IAQ67_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07480"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_103048208.1"
                     /sec_met_domain="TIGR03731 (E-value: 9e-05, bitscore: 20.7,
                     seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKNEVAPKGVQPASGLICTPSCATGTLNCQVSLT
                     FCKTC"
     CDS_motif       11560..11631
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKNEVAPKGVQPA"
                     /locus_tag="IAQ67_RS07480_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11632..11712
                     /prepeptide="core"
                     /locus_tag="IAQ67_RS07480_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="5.90"
                     /molecular_weight="2508.0"
                     /monoisotopic_mass="2506.2"
                     /core_sequence="SGLICTPSCATGTLNCQVSLTFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKNEVAPKGVQPA"
                     /leader_location="[11559:11631](+)"
                     /alternative_weights="2526.0"
                     /alternative_weights="2544.0"
                     /alternative_weights="2562.0"
     gene            11789..13051
                     /locus_tag="IAQ67_RS07485"
                     /old_locus_tag="IAQ67_07485"
     CDS             11789..13051
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="IAQ67_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07485"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_190299518.1"
                     /sec_met_domain="LANC_like (E-value: 3.9e-59, bitscore:
                     198.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEDLQVRSVEISKYIAQKLIDLSYTEKIVNHANNLSPSRGNSPW
                     NPSSLADGIPGVLVLLSEWGYLEPDQNWAEHVHSQLRYLDANSLLLLPRISLYYGTTGV
                     AYGILLASNNRANYNKLISQLNKYIEVKWGDLPVIGTTTEFSRQMDIINGLLGVGRYTL
                     EVAEDKAMCNLSRQLLDTITHFIPEYIHLSSREDSASIHLGLAHGITGILALLVTALQK
                     KIKVEGLHEAIKHIADFLLIQIQEDQYGWYWPVNSQAPSMNKREKKVGMREIEGWCHGT
                     FGIGWTLFRAGIEYSNEEWKKIAEKAMQSIFCLDDELLNALSPTFCHGLAGLLHIAHRF
                     YNLTDNIAALHFADQIALKLVNLYDEELPFGYQDLEGTTHVHNVGILQGATGIALSLLD
                     YGIGKEHPKYSGRWSELFLIS"
     gene            13101..13778
                     /locus_tag="IAQ67_RS07490"
                     /old_locus_tag="IAQ67_07490"
     CDS             13101..13778
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="IAQ67_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07490"
                     /product="response regulator transcription factor"
                     /protein_id="WP_103048206.1"
                     /transl_table=11
                     /translation="MKQKFMVISSFRKIKHFFETLNTPENIRIMFYDSLYQAIPEIDEQ
                     CIGVALNQDHVTLEDLSYWHSIKEKFTVPFIFLSYHSDDQRQLDLLKQLFSMASPEYGM
                     EREQQAISLSPNVIFDPAGKVIWKQGHEHTLTMMEFRLLMYLLTAKECASTIDHIIDRV
                     WGVDAFTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYKLNIFPKNLEVVSCEETT
                     ALY"
     gene            13753..17007
                     /locus_tag="IAQ67_RS07495"
                     /old_locus_tag="IAQ67_07495"
     CDS             13753..17007
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820473.1"
                     /locus_tag="IAQ67_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07495"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_190298924.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.8e-191,
                     bitscore: 633.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.4e-14,
                     bitscore: 51.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3e-53, bitscore:
                     179.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRQLHYTDAQKLHNEVRDRDERWFSACDFFLIRAPLLPLDRYFQ
                     VFSDQDVDSQLTLEEITRRLKLISQEAVVQEAISLASPSLMQFLHYLNDGHALDDKGEL
                     QKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICGKTTDLDIGSYPKHLKRARPDMEW
                     IYKLIQKIEADPAIFNQLKVFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRFT
                     DVVRMTFEAAEHPIRVMELKEILLKAFPDATLEIISDYLQQLVEQEFILSELRPPLMDH
                     SPFHYIFEKIRKLDISDPWVHILHEIDALLLQYNQCTIGEGEKVYRKLCDKMLDIISVK
                     TPVQVDVKLDKDVTLPKHVLDEVSLGAEVMCKLYASPKTDELDEYLNRFLEKYGVYQEV
                     PIHELFDEDWGLGIPEMYRSNEKKSMGMEAFKRNAVLFQWVSNAISNHEIELALTDEQL
                     EQLMISDNYDTSPESMEIYYSIFADSPEKVDSGDYSLLLGASAGSNRAGKTFGRFLDML
                     SEEFVQKFSEIYDHHRCFHPDALLSEMVFMPEQGKISNISLSKNLMAYEIVSGTTSSKD
                     EDHTLCIDDLVVGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPHIFRFLTDITNKEIG
                     TWSYFDWGPLEQSPFLPRLVYKKIIISAAQWKLSKASLNISESCESKEGEALFHVWRQQ
                     WNVPRYVYLTMGDNRLLLDLCNLFHIKELLHEVSKTREGQELLLTECLGNPFHTPVQGT
                     AGRYMGEFVFPLKKKKIKVKPSIPSSQNHIVSQNFIAHTPSSIHRGIFPGGEWLYLKLY
                     GVKERETDLVGISLGHLLKQPGFKDWSQKFYFLRYVDPEHHIRLRFQGEPDKLWTAGLA
                     QLNQWAAELREEGLITNMVIDTYHPELERYGGQTLMELAEQVFDVDSQWVIAYMKGIRS
                     NAFNLDIEIAAVMNIIHYLSGFGLTIQEQVKWLEERIDCKPHMKAFRDVKKTLITAVES
                     NYEWIGQADTNTQVAFLALVEKRQAMIQQYAQAIILAKNNHELTNHPDDILGSIIHMHL
                     NRLLGVNREREIKCMALAKHTVANLLHRKGVSYVTV"
     aSDomain        14299..14583
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IAQ67_RS07495_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-16"
                     /identifier="RREFam001.1"
                     /label="IAQ67_RS07495"
                     /locus_tag="IAQ67_RS07495"
                     /protein_end="277"
                     /protein_start="182"
                     /score="51.6"
                     /tool="antismash"
                     /translation="VFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRFTDVVRM
                     TFEAAEHPIRVMELKEILLKAFPDATLEIISDYLQQLVEQEFILSELRPP"
     gene            17141..18895
                     /locus_tag="IAQ67_RS07500"
                     /old_locus_tag="IAQ67_07500"
     CDS             17141..18895
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="IAQ67_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07500"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_223822032.1"
                     /transl_table=11
                     /translation="MKGAIPAVILLTTRELINSVVAGASGGSFQPVFIAFGVLIGVNLL
                     YDLINIGESFFRKMFQSRLSNQVNIKIIEKAQKMSLQSFEDADVQNMLQRAQGEADFRP
                     FEIFTQILAIISSVVTLFSTGAILIAWRWWAFLFIFLIPCLSFYSFLRIGQREFNVHFQ
                     RAGRQRESWYLSFLVTRDNSFKEVKIFQLGDYLRKRYKTILEGFYREDKVLAIRRSYTS
                     LVFQIVNQGACAFIIFMAIQATYVGQILVGNLVSLIQGITLTQSTSQSIVQGILSLCQN
                     NLYIKQLFDFLDMPEEEKIQKTVQQLPLSTIHSIEFRNVSFRYPNTEENAISNVSFKLH
                     QGEKLAIVGRNGSGKSTIVKLLTHLYSDFEGEILINGYSIHELDKDIFREKIGVVFQDF
                     VHYEMAVRDNIGFGNVASRENDEAIWTAIDKAGITDLIVGLPDKMNTLLGKWFEDGQQL
                     SGGQWQRIAIARAFMRNADIYVLDEPSSFLDPHAEKEVFQKFDQLIYEKIGVFISHRLS
                     SARMADTIILMEEGRIVEAGSHERLMDIDGVYAEMFRLQASSYLSQRECDFEEEDLSPS
                     LVRTTGGS"
     gene            complement(18940..19263)
                     /locus_tag="IAQ67_RS07505"
                     /old_locus_tag="IAQ67_07505"
     CDS             complement(18940..19263)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003331885.1"
                     /locus_tag="IAQ67_RS07505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07505"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_134904518.1"
                     /transl_table=11
                     /translation="MSINPNVLYIIIGAMIVTAIPRIIPFVVLQRLALPKPVLQWLSYI
                     PICIFTALVMENLLVRTESSVTLNGQVLMAVFPTLVTALWSKNLLATVVIGIVSMAVVR
                     LLW"
     gene            complement(19260..19985)
                     /locus_tag="IAQ67_RS07510"
                     /old_locus_tag="IAQ67_07510"
     CDS             complement(19260..19985)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="IAQ67_RS07510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07510"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_134904519.1"
                     /transl_table=11
                     /translation="MSIASELSGTKPDSLSFLHGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIAFMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLWKNIGIGALLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIVSCVAGGVLG
                     NWISRPEAFGLDFALPAMFLALLISQLQSVQTSKLKHRLLLVLCMAVLMYLLAWWVPSH
                     IAVIVATMITATIGVLTDK"
     misc_feature    20005..20018
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     gene            20500..21468
                     /locus_tag="IAQ67_RS07515"
                     /old_locus_tag="IAQ67_07515"
     CDS             20500..21468
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820912.1"
                     /locus_tag="IAQ67_RS07515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07515"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_103048201.1"
                     /transl_table=11
                     /translation="MPSIKDVASLAGVAVGTVSRVINNSGSVKPDTRRKVEEAIQELNY
                     FPNEVARNFKMRKSKMVALLLPSIWHPFFSELAYYIEDELDREGFKLMLCNSGGKPEKE
                     LYYLDMLRQNKVAGIVGITYNDIENSVSNDIPIVSIDRHFNKKITCVTSDNYEGGRLAL
                     RELVKVGAQKPAFMGSVTSVFSETMNRRKGFIHEAQTLGVDYVIYEKPDPIVDDDAYFN
                     EFLNEHRDVDGIFAITDMLAANYIERARRQGIRVPEDVKVIGYDGIQDHPYFHPILSTI
                     RQPVEEMARMTIRLLYKKIEGETLDQQVYRLPIVFKQGETT"
     gene            complement(21689..23071)
                     /gene="rpoN"
                     /locus_tag="IAQ67_RS07520"
                     /old_locus_tag="IAQ67_07520"
     CDS             complement(21689..23071)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpoN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428384.1"
                     /locus_tag="IAQ67_RS07520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07520"
                     /product="RNA polymerase factor sigma-54"
                     /protein_id="WP_190298926.1"
                     /transl_table=11
                     /translation="MIRYGLQQEQGFKLVMTPELRQAITILQYSSADLISFLHEQANNN
                     PVIDLPEFNMSIGSIKEEAERFSQKNQGDLLERYRGGEKYPSVQRANPVTFLDFVPNPN
                     DTLFEHLNRQLGLVCGLTNSQRMVARYLIGNLNEMGYLELDVPTVASLLDVPIAEIEDM
                     LLVIQSFDPPGIASYSLEECLLLQLQLAGMDDECIVRMVSNHLADLANNRIQKIADALE
                     ISRQEVIQMADRIRKLNPCPGAAFAHKEQQYIIADITVEKANGEYLVLINDISAPRVEI
                     NPFYRQMMQDLPNSETKRFIHEKMNTAKWLINSLKQRRLTLLRVAKAIVEKQQDFFEHG
                     VYFLKPITQKEIADKTGLHESTVSRAVSNKFIQTPRGLFELKFFFTSSLTSADGDAASS
                     ESAKKRIKNLIDDEDKQKPLSDQALTTLLGKEGLHLSRRTVAKYREELRYLSSAKRKKF
                     EV"
     misc_feature    23295..23308
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.68"
                     /tool="antismash"
     gene            23347..24168
                     /locus_tag="IAQ67_RS07525"
                     /old_locus_tag="IAQ67_07525"
     CDS             23347..24168
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179: hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309474.1"
                     /locus_tag="IAQ67_RS07525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07525"
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="WP_190298927.1"
                     /transl_table=11
                     /translation="METYKIVCIDIDGTLLNSAHQITEATKETILQVINDKQIPVVLVS
                     ARMPKAIIPLQKHLGISEPLICYSGALVIDKHGNKLNTRYIDKKMTQRLLDSLAAYDLH
                     VSLYKDDEWYIEQLDAWALQERDITNIEPRIYSFSKLTNGWREETDGTSKILCMGDPEE
                     IRRVLQVLRPVYGEEVNLYLSKPTYLEIMSKKASKTAAIQILLKEYQLKQSDCLAMGDN
                     YNDIDMLAFAGLGIAMENAPLEVKAAANTVTLSNDEDGVAHALKNHILFPK"
     gene            24218..26998
                     /locus_tag="IAQ67_RS07530"
                     /old_locus_tag="IAQ67_07530"
     CDS             24218..26998
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008134 - transcription factor binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1112: sigma-54
                     dependent trancsriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369098.1"
                     /locus_tag="IAQ67_RS07530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IAQ67_07530"
                     /product="sigma-54-dependent transcriptional regulator"
                     /protein_id="WP_190298928.1"
                     /transl_table=11
                     /translation="MKRIDKILEYIAESTKKISKEALFAGEGITAAEIADDQKMLRNNV
                     SKELNNLLRDDLILKIKGRPVRFLHKQIIEDTFRVRLKEKQIEVKSIKEVLLPDQQVDP
                     FHALIGFRGSMRNQVEQGKAAILYPPRGLHTLIVGQTGVGKTMFARLMYHYGKYMKRFS
                     EHAPFIVFNCADYFNNPHLLLSHIFGHVKGAFTGADHEKAGLVEKADGGILFLDEIHRL
                     PPEGQEMIFYFMDTHTYNKLGETDRKRDASVLLIGATTEDPGSSMLKTFIRRIPITINI
                     PSLQERAIEEQMLILKHLFANEANRVNKPIRIESEVVRALIGSVTYGNIGQLKSNIQLV
                     CAKGFLNSIHENKEEIGLDFKNLPGNIRDGLFNIDKTQYKMKEIGCISSGLYITPEGRK
                     ALDEEVVSELPFNLYKLIEDKIGMLKEEGLDDAYIHRFIATDVNIHIKSFYNRFYNTKG
                     SRERILKIVDKDILEFSEQIKEMAKKELNRIYSERFVYAFSLHLSAFFKRTREKKYGDA
                     RIYEPMNDHNEEYRLAQTIKSLIESKFGVHVPEAEITYMAILLKSVEEERQGSVGIIVA
                     AHGTSTASSIVGVVDSLLGSSNLCAVDMPLDVSPREILELIIDKVKSIDRGRGVLLLVD
                     MGSLLNLEETIMERVGINVKTIDMVSTPLTLEAVRKASVFDMGIEEIYQSLKDFRGYNN
                     SSAAVKVVHKAIVTVCSSGKGAAVKLKEFVEKIVCDLTDEEILVVPANVRELDKVVQDM
                     RSKRTILAVIGVKRPSEPEIPFIPLEKLIEASGEQTLRELLLNNKQIPAVDQSVVVREL
                     CEESLKEFMTYLNPHKVLGMVMRFVQELELGLEVKFDYATKVQISTHTAYALERMVIRD
                     GLVYQGEVRKLDQRIFEVVNRSCSIFVSGMNLILSDDEKYYICEMLSEVYNFIPQ"
ORIGIN
        1 ccatcagcaa gaaagcttgc ggtccaccga ccaacagaag cgcaaacgca accctacagg
       61 cttgagcctg cgttggaaat ttccgctggt actggcggct ttgctgcttt ttactgtcgg
      121 tgtgctgagc tggcttgtgc ttactggcat tcgtgctaac cagacagacc aaatggaacg
      181 cagcttaaag cgtcaggccg aaattgtaga aatgcgtgta aaacagtctt acctgttggg
      241 agtgcgccaa tcaccggaag actttatgaa gaagcaggca cctgggctcg cagtggaact
      301 gggcatatcc agtaatatgc gcgttatttt atatgatggt caggggcatg aggttggcaa
      361 ttctctaccg ctggctttta gaacagatgt cagccaggcg ctctcctatg cgatccaagg
      421 caaaattgcg tatattacgg aaggaagcgc aatcacttat ttggctccgc ttcaaggtcc
      481 agacggctta ctgggagtgg tacagcttca cagctcaaca gaagcgcagc agcagttcta
      541 cggggccatt gcccacttgt ttttatggac ggggggtgcg gtgctggtat tgagctttat
      601 tttgggttta ggctatgtca gccgccagac gagggacatc ggacgactga ctcgtgcttc
      661 cgaacagata tcggcagggc attatccgga agccagactg ctgcggcggc aggatgagct
      721 gggaagactg gatgaaggaa tgctccagat gagtcatgtg atccgggaga gcattacggc
      781 gctggaaaac gaaaagctcc ggctggaaga agcggttcag cgtttgagag agctggagca
      841 acagcaaaaa tcttttattg gaaatatcag ccatgaacta aagaccccat taacctctat
      901 tcaagcttat gctgatttac tcgatatgta tggggatgat cctgaactgg tgcgtgaagc
      961 gagagaaagc atcagtaagg aaacaaaacg gttgtacgag cttgtcgagg actcgctgcg
     1021 gctatctgtg ctggataaat atgattttga attgcatacg gaggctgtgg aactgcattc
     1081 gttactggaa gatgcaggga gtcgtattcg aggaaaagcg gcagcgcgta gactgaattt
     1141 ttcgatagat accgttcctg cccaggtgtg gggagatcct aagcatctaa tgcatattgt
     1201 attgaatttg ctggataatg cagtgaaata caatcgggac ggaggctgga ttacgttatc
     1261 gaatcgggta gaacaggata ctgtgatggt gtatatacgc aattccggtc catggattcc
     1321 aagggagcaa tgggacatga tttttgagcc gtttgctacc ttaagtcgtg atcgatctcg
     1381 tcaggacagc ggtacgggac tcggtcttcc tctggcgcgc agattggcgg agcgcatggg
     1441 gggagagttg cagcttacag cttcagatca tagtgagttg gaaaatggca acggccatac
     1501 gaatgtaagt ggtaatgaat tttcgcttag actccccctc ttggttcacg atagctccct
     1561 gtaaacggcc gattgttagc acagggctag aatggtgtct tgtttacaac ttggaaacaa
     1621 ttcgatgtat tcatgagatg ttcagacatt aaactggggg tatcgttaac aaggaggccg
     1681 ttgtacatga taaagaaaaa catagacagc tataggcaaa agaacggctc ctctcatcgc
     1741 gaagattccc gtacaagagt tttcagacag aaagccacgg gggtgctcat gaccggctta
     1801 atcgctgggg gattgctcag tggttgcggc atgaagagcg caggagagac aaatccagca
     1861 ttcggtatga aaccgggcca acagcttact gtgattgaca cggatacagc ccagaagcaa
     1921 gtaacggacg agctggtggt atcgtctatc gacaggctgg gggatgtcta cgcaaggtct
     1981 tggctgagcg acgaagagct gattgtagag agacagacca ggctgttgat tcataatgta
     2041 aagacaggca aggagcggat tttaacacca ggtcgtaagg ctccacagtt acttgctgtg
     2101 gtatcaccgg atcagcgcca tgtctttttt actgaaggta gcaccagcag caagtatgat
     2161 atccagggct acattttgga actaagcagt ggtaaggtta catcgattgg caagctggat
     2221 atgactaacg aagtgagctg gagcgatgag aatgatctca ttacaggcag accggatggt
     2281 aaaatccagc tgattggtct ggacgacaaa gctgaagaat tgagttttca agatccgaat
     2341 cgctctgaat tgatttctca tgtcgaaaaa gtgggtaaca ccatatttta tacaggcagt
     2401 gataaacgag ggtatccggt gctgaatcgg ttcaccctca atcatcctca ggctataacc
     2461 attgcagagg gtgccatgtc ctttgccgtg tcgcctgacg gtaagtctat tgccattgaa
     2521 aagcggaaat ggaatacatc cgaaccagcc cgtatgatca ttttggatga acagggcaaa
     2581 gagaaaggaa tcgtcggtca aggtacttta atgagtcgtg gaagctggtc cagcgacggg
     2641 tccaagcttg ctttttccat ttatgatgag gatcagcaag gcatgagagg gctgtatgtg
     2701 tttgaccagt ccacgggtaa aaccactccg gttacgaccg atattcaatc ctatgacagc
     2761 ccaacggtat ggagcccatc cgcacggttt ttatccatgt accagaatat ttcggaaggt
     2821 ggaaaacagc tcaatcaaag ctacatcgtc gaatttaaga ggaagtagta aaaggcgcat
     2881 atccgtttgt tcggaatgcg cctttttaaa tgtaggctgg caattgattt tgtatgacta
     2941 tacaaacttg cgatgatgtt ttttaccatc atatgagaat aaggcgagct taccctcaat
     3001 caaagtttcc aaatgaacgg tgcgccccca cagctgatat acatacggaa gtgtgcgctc
     3061 catatatttt aaatccagct caatgccttc gtactggtgc ttgagcttca actcgcccgt
     3121 atgcaggtaa tctccatcct cgacgacgat ataaggtgag cctccattca cacgtgaaaa
     3181 cacgagctga tctcgtatgt tttcccaaga tttatcggtg attttccaat cgggtccccg
     3241 tttctcaaac acgtacagat ccaaatcctc tgtcagtttc ttggtcatgt aattgcgtat
     3301 aaaagaggtg tctgagtcga actctcgtac ctcgaacatt ttagctcgac cctcgcccgg
     3361 tttgcgtcct tgtcgctctt gctcctcacg ggttgggtta tcccatcgtt tttcaatatc
     3421 ctcaaatatt ttcagcccca aatagtacgg gttcaagctt tgcttggaag gctgtacgac
     3481 agaagcgttc agcatcgcaa attcaacggt ttcctccccg gtcaaatcca gttcccttac
     3541 aatccgctgg tgccaatagg aggcccagcc ttcattcatg attttggtct ccatttgggg
     3601 ccagaaatac agcatttcgt cccgcagcat cgtcataata tcccgctgcc agtcctccag
     3661 cacctccgag aattcctgaa taaaccagac gatatctttt tcaggttccg gcgggaactg
     3721 gcgtatcttg atgccctcgg tctcggccgg atcatgctgc ttcactttgt ccagtgacca
     3781 cagatcatcg taaggcccag gggggcgctg gcgttttcca ggttctttct gctcccggat
     3841 tttgagctcc atatagcgtt gtttatccag atgtctgggt ttgatgatct gtggatctac
     3901 atgttcttgt atcgccagta cagagtcaat gaaggattcc acagcctttg aaccgtattc
     3961 catttcatag ctgttgattc gatctgctgt ggccgacata ctctccacca tattgcgatt
     4021 agaagctgaa aagcgagcgt tgtgtttgaa aaaatcacag tgtgccagta catgagcgac
     4081 aattagttta ttttgcacca aagaatttcc ttccagcagg aaggcgtagc agggattgga
     4141 gttaatgacc agctcataga ttttactcaa tccaaaatcg tactgcattt tcatcttgtg
     4201 aaacgttttt ccgaaactcc agtggctgaa gcgcgtgggc ataccatagg ctccgaacgt
     4261 gtatacaata tccgccggac aaatctcata ccgcatcggg tagtagtcga gcccgaatcc
     4321 atcggcaatc tccataattt ctgatatcgc atattctagc tccttctggt cggtactcat
     4381 cccaccgatc ccccttcctg tttgcgaaaa aaggtacgta aggcttggta tacctcacct
     4441 ttttccttga tgacatagta cataaactga tcctttttaa tattcttgta ggctgacatc
     4501 agcgtgctgc tgcgattata ttgattcact tccccatagc cgaacatatt gctccgcttt
     4561 ataagttcct cgattagctt cacacaccgt tcattgtccg aggtcagatt atcaccatcc
     4621 gagaaatgga agggataaat attgtagctg gaaggaggat atcgtttgtc gataatctcc
     4681 agtgctttca aataagcgga agagcagatc gtgccgccac tttctccgcg ggtaaaaaat
     4741 tcttcctccg taacctcttt agcctcggta tgatgcgcga gaaagacaat ttccaccttt
     4801 tcatactgac ggcgcaaaaa gcgggtcatc cagaaaaaga agctgcgagc gcaatatttt
     4861 tcaaaagagc ccatcgagcc tgatgtgtcc atcatggcta taatcaccgc gttggattga
     4921 ggaatagtct tctcttccca tgttttgtag cgaagatcgt ccggactaat atgatgaatg
     4981 cccggtttcc cttcacgggc gttgcggcgc agattttcga gaatggttcg tttcttgtca
     5041 atgttcgctt gcatgccttt tttgcgtata tcattgaaca cgatagattc aacctcaatt
     5101 tgatccttat ctttttgctg taaattcggt aattccattt cctcgaacag catatcttcc
     5161 agttcttcta tgctgacttc cgtttccata atatcgtgtc ccggctggtc gccggctttc
     5221 tcacctttac caggcttctg ggaggcagga tcacgtccga tgacatcccc cacctgacta
     5281 tctccatccc cttggcctac atgcttttgc ttttgatagt tataaatgaa gcgatattca
     5341 tccagactgc gaatcggcac tttaataatc tgttgaccgt ccgacataat aatattttct
     5401 tccgttatca gatcgggtag attttgctta atgacatctt tgaccttctg ctgatgacgt
     5461 tgctggtcct ggtacccttt gcgatgcagc gaccaatctt cgcgggatac gacgaatgaa
     5521 tatggctggc gtggttccgg cattattagg caccccccaa gtggatacac ggcacagttt
     5581 ggccttgttg gttattaagt atattcacgg ggatgaacga tatgtgatgg aactcgattt
     5641 aaattctgcc cgtttgcttt tataatgaaa gtaaaaaatg taaaaaaaga atggagaacc
     5701 ttgggttatg gaagaaattg cagtacttat agtagatgat gagcaggggt tgcgggatat
     5761 gctgacaacg gtgttaaaaa aagaagggtt ccttcaagtc aagcatgctg caacaggtcg
     5821 ggaagcgctg caagtcgtga tggaatctca aatggatgtg attgtacttg atgttatgct
     5881 gcctgatagc gatgggtttg aggtgtgtcg tcaaatgcgt ctatatacgg atgctcctat
     5941 tctttttttg acggcaagag atacagatct ggacaaatta atggggtttg gcattggagg
     6001 ggacgattat attaccaaac cgtttaaccc gctggaagtc gttgcccgta tgaaggctcg
     6061 aatgaaatat cggaaagttc cgactgtggc catgaaaccg gccttacgca ctttagattt
     6121 tggatatttt cgtctggaac tagaagccgg tgtgttgtat gttgaggaca agcaggtcga
     6181 gtgtccggcg cgtgaatggc tactgctggt atttttgtgc aagcatccta accgtatttt
     6241 cagtgtacgg cagctttacg aggcgatatg gagcgaggct ttcttgggtg atgagaagac
     6301 cgtagtgatt catatctccc gtttgcggaa aaaaatagaa cctgatccca agcacccgca
     6361 atttttaatc aatgtaagag ggcttggtta taaaatgatg tcagtcaaga tgggggagca
     6421 agaatgaact ctctagttaa gatgtccttt cgttttatga aagtaacgtt atgctttgta
     6481 ctggcctatg tcctatgttt tgttatttgc acgatctttt atatttttat aaaaagtata
     6541 tttggagcat ctcaaaatat aaatattgat ctattctgga caggacttgg tatcgtgcag
     6601 agtgttgtgt tcatagctgc ctacggatgg tatataggca aacctttggt gtatgtaatt
     6661 aaatggattg gaaatattgc gacgggggaa ttccaagcgc cgctaagtga actggaactg
     6721 ccggagggca aaaaaaatca gaaaaatagt tataaacctc cgtatcaatt gtataaagaa
     6781 gtttttgaac aaatgaacat cttatcggct caattgcgca gcaatgagga agagagagtg
     6841 gaaatagaga aacgaaaaca gcagtgggta gcaggtgtaa gccatgatct caaaacacca
     6901 ttatcttata ttgaaggata tgcggccatg ctaactgctc aagagtatga ctggtctgat
     6961 gaagaaagaa gaagctttag tatgagtatc agtgagaaag tgactgaaat gaagcagttg
     7021 attcaggatt tgaatgcttc tatgcagctt aaggaaagtc cattgccaat ccaattggag
     7081 aaggaggaca ttgtggagtt tctccgtagt gcagtaatag atatcgctaa ccatccttcg
     7141 gccgagcaat acgaattttc ttttacgtcc atggaggcgg catgtattat gcccttcgat
     7201 agcaagttat taggcagagc gctgcagaat tttttgatta acgcaatcat tcataatcct
     7261 ccaggtacac acgtttccat gaaagtaaac aaagcgaacg ataagcttca tatttctatc
     7321 gaagatgacg gaataggaat gaattctaat aagttcatgc aggtacctca ctcccaaggg
     7381 catggaatac ctattgccaa aagctttatt gaagcgcaca acggaacgct tcatatcctt
     7441 ccaggcagta aagcgggtac aaggatggag atttcactgc cgctaaacat ctaatctcac
     7501 attttgcagt ttgctcgatt tttttgcctg ttgtttaggg actgtttacc tgatgtttac
     7561 tttactttag taaactgtgt gtaacttaag cttcagcatt agaagtcgag aggagatcag
     7621 gaaatgtctg aatatgtaat acatacacag cagctaacta ggcgttttgg aaaacgggaa
     7681 tttgtaaaac gaataaatct ccaggtaccc ggacagcaga tttatggatt tttaggacct
     7741 aatggggcag gtaaaacaac cacgattcgt atgctacttg ggctgattaa atccacatcc
     7801 ggagaaattg agattttcgg gaaaaagcta aaggatcagc gtatggaaat attgaaggat
     7861 gttggctcct tggttgaatc acctgcctat tatgcccatt tatccgcata tcgaaatttg
     7921 gaaatcgtta caaccatgcg tggactgccg acccgaagaa ttcatgaagt gctggattta
     7981 gtgagattaa cgaaggatgc gtatcgtccg gtaaagggat attccttggg gatgcgacaa
     8041 agactgggga ttgctatggc gcttattgcc aaccccaaat tattgatact agatgaaccg
     8101 acgaatggtt tggacccgtc tggtattcag gaaattcggg agttaattat gagccttcct
     8161 ggcgcttacg gaatgacggt actggtttcg agccatttat taagcgaaat tgagcagatt
     8221 gcaacctatg taggaattat taatcagggt gaaatgattt tccagggaac gatgaaggaa
     8281 ctcaccgcca aaagcaagcc tcaattattc attgaaaccc cagatcctgt tctggctgcc
     8341 ggtgcactga ttcagcatgg atggacagcc ggagctgaat cgattgaaca aaatgaggtc
     8401 gtgactccta ttgtagatcg gcaacaatct tcggagatga tcaaggtgct tgtggagcac
     8461 aatcatccca tttatcgggt cacagagaag aaaaaaacct tggaggagat attcctggaa
     8521 ctgacaggta aggagcgaag cttatgatac tccgggttat aaaggcagag gggcttaagc
     8581 tgaagaaaat atgctggtgg attcctctta tacaggggtg tgtacttaca ggcatgactg
     8641 ccgtggaatg gtatctttac tttcggcaag gaccaggggg tgtctatgct ggttttgccg
     8701 ttatgtttat gttcctttcg tttgtgatgc tgcttggcgg tacacttttg gcgagcatta
     8761 tggccggtac agagcatgat actcaaacat ggaagcagct tatggccatg cctgttccca
     8821 gaagccatat ctatttatcc aaaatcgtat ggatcgtgat tctgcagttg ggtaccgcct
     8881 tgatcactgt agcaggtatg agcctcatct gggtgttata tacaaacgaa cccattcctt
     8941 ggcggatcat gctgttacag ccgattaatg caagcttggc taccctacca gtacttgcaa
     9001 ttcaactttg gctgtctacg cttttcacta atcaggcatt cccattagcg tttggtatat
     9061 tcggttctat tgcaagcttg tttttggcac gcacaagtat tctgtggatt aaaatattgc
     9121 cttggtcgta ccctgcactc tcaagtcctc tgatgaagga acacatgatt tgggtgatcg
     9181 ttgctttaag tgcgggagtc atctttacgg gacttggtac attacagttt accaagcatg
     9241 aattcaaata gagaggagaa gatacatggg ctctatttta cgcgtagaga cgataaagct
     9301 tcaatggatc atggtatgga ttctcattat attagatgcg gtcataaatt ctttaatggg
     9361 agtcctggag ctgaacgatt tgaagcagtt tttttcgccc agctggttaa ctttatatac
     9421 gtattcagcg caatttcact ctatgttttt ttatccgctc tattgtggaa ttatcgcttc
     9481 tcttttgtgt gcgtatgagc atcgggatgg aggatggaag attttattaa gcagcccgta
     9541 tcctcgtcag caaatttatt atgcaaaata tatattgctc attctcatac tgggtcttga
     9601 tcagcttata tttatagtag gctattttgt aagcggaaat atagcaggtg ctccaggaga
     9661 aatcccttgg tctgtcgttc tttcaaccgg tttgggaggg tggctcggga tttttcccct
     9721 ggcagcacta cagcttatgc tctcgataaa aattcggaat tttggagctt ctctgggaat
     9781 gtctatttgt tgtgtggttc ctaatattgt cataacaggc tttcactctt ccataggtgc
     9841 gtggtttcct tttacgattc cttattatat tatgatgccg caaacagcga gttatgcacc
     9901 cagagttgag ccttacagtc ttggattgat tgttattttt acgtttttag cctatctgta
     9961 tggtgggaga aagatgtttg tgaataggga ctggttgtag ttaggatagc atgaggatgt
    10021 aatcccaacc gatctctttg ttctcagaaa cacttaataa agcagctgca atcccagcaa
    10081 cgccttcaag catgcccgct tttgtcagcc aagtcaaaga gccatctgac cttggctcgg
    10141 ggtccagata tccaagtggg ctatccattt gaaagcgatc aagcagacta ttcgttaact
    10201 gttgaataag cgggagaaat gcaggctctt tactgtgacg ccacattcgc caagagatgg
    10261 taagtaatcc ggcaagaccg tgacagagtg cagaagagtc catttcccgc ttagctatct
    10321 cataggagat tgcaccgaca caagctttca cagctgattt ttgcagttcc acattatgga
    10381 gagcctttcc ggcaagaaat agggaacagg tgatgccggg tgtaccgtag caccatgctt
    10441 ctcttgctcg ttccaaatca aaccgcagag agcctgtttc agcttcaaat ggaacaatat
    10501 gaggccagta gctaccatat tcatcctcat atttatactt aagcaaccat tccgtaatgg
    10561 tttcaatcgc ttgatattgg ccttttactt caattccaga actataagct acagataata
    10621 aagccaacgg tccaggaatg ccatgtgcca ttccacaatt gaaattgccc agaggatagt
    10681 tacgtttatc ccggtctaaa aattgaaact tttgtgggga gtaccaccct gggacataat
    10741 gattgtgaat atgtatggga tgtgtaagat cggtaagaaa ttgaagaatt ggctcaacaa
    10801 gaggagtaca aataggattg gttgagttta tcaaaatata tcttccaatc ccggaagctc
    10861 ccgaaatggt gtcaaaggat tgcatgggca taccttcgtg aagacttaat tgttctgtgt
    10921 tcgactgaag ccattgctct gttagaggca tcatccattg atgtatttgc tgtgaaaaat
    10981 tgctgtagta ttctccataa ttagaagcct ctcttacgga cgcagcaatg cctgcccagc
    11041 cactgtaaag agagaggtcg tgaagaccat ttatagcaag tgaggattgg atctgagcca
    11101 tatttaaatg tatggctcta ttccaatcat acgaaaggtc tgtagcacgc cattgcgata
    11161 gtaaatgaat gttaccagga taaccatgcg aaagtgaggt ttctccccat gggtggtact
    11221 ttgtttctgg cgaaacattg tgttccgaat ggactgctga atagacggat tcgggctcgc
    11281 acagacgtaa agcaattttt ttactaatat ctcttgcacg aacttggtcg gattgttgta
    11341 taacaaaact atcaattttc atatgaaagc ctccattata ttttccctca ttatattgtc
    11401 actaaaatct agtgtgctgt ccttaaaaat actaaaaagt aataaaggtt tatcttaaat
    11461 gtattcgttg aaattaagac aaatgtaaga aatatataaa gtctagttaa gattatataa
    11521 cttataataa aattgtaaaa aataaaagga ggtaacaaga tgaaaaatca atttgatctg
    11581 gacttgcaag tagccaaaaa tgaggttgct ccaaaagggg ttcaaccagc cagtggtctt
    11641 atctgtactc cttcatgtgc aacaggtact ttgaattgtc aagttagtct taccttctgc
    11701 aaaacgtgtt aataacgaaa atacatggaa aaaaggcacg gtttctataa ccgtgtcttt
    11761 tccagttatg aaaatgaggg aaggatttat ggctgaagat ttgcaggtga gatcagttga
    11821 aatcagtaag tatatagcac aaaagctaat agacctatca tatacagaaa agatagttaa
    11881 tcatgcaaac aacctttcac cttcacgtgg aaattcccct tggaatccta gctcgcttgc
    11941 cgatggaatt ccgggtgtgt tagtgctgtt gtccgaatgg ggatacctgg agcctgatca
    12001 aaattgggca gagcatgtgc atagtcagtt acggtactta gatgctaact ctctattatt
    12061 attacctcgt atttctcttt attatggaac aacaggagta gcttatggca tattgttagc
    12121 ttccaataac agagctaatt ataacaaact aatctctcag cttaataagt atattgaagt
    12181 aaagtggggg gatttacctg taattggcac aactacggag ttcagtaggc aaatggatat
    12241 tatcaatgga ctgcttggag tgggcagata cactctggag gttgctgaag acaaggcgat
    12301 gtgtaatctg tctcgtcaat tattagatac cattacgcac tttatacctg aatatataca
    12361 tttgtcgtca agggaagatt cggcttcaat ccatctaggt ttggcgcatg gtatcaccgg
    12421 aatacttgca ctgcttgtca ctgccctaca aaaaaagatc aaagttgaag gactacatga
    12481 ggctataaaa catatagccg attttttgct tattcaaatt caggaggatc aatatggctg
    12541 gtattggcct gtaaactctc aagcgccttc aatgaacaag agagagaaaa aagtagggat
    12601 gagagaaatt gaaggctggt gtcatggaac ctttggaata ggttggacat tattcagagc
    12661 aggaattgag tacagtaatg aagaatggaa aaagatagcg gaaaaagcta tgcaatccat
    12721 attttgctta gatgatgagc tactaaacgc gctatcccct actttctgtc acgggttggc
    12781 tggtttgctt catatagctc atagattcta taacttaacc gacaatatag cagcgttaca
    12841 ttttgccgat cagatagctt taaagttagt aaatttatac gatgaagagc tcccatttgg
    12901 atatcaggat ttggagggga caactcatgt tcataatgta ggaatactgc aaggggcaac
    12961 agggattgcg ttaagtttac tggactatgg aattgggaaa gaacatccta aatattcagg
    13021 gagatggagt gaattgtttc taatttctta agggtgctac cttattgctt tatctgaagc
    13081 attggttttg gggggattag atgaaacaaa aatttatggt tatatcatct tttaggaaga
    13141 ttaagcattt ttttgagact ttaaacactc cagaaaacat tcgaatcatg ttttatgatt
    13201 cgctttacca ggctataccg gagattgatg agcagtgtat cggtgtagct ttgaatcagg
    13261 atcatgtaac gctagaggac ttgtcttact ggcacagcat taaagaaaaa tttacggttc
    13321 catttatctt tctttcctat catagtgatg accaacggca attggatctc ctcaaacaat
    13381 tgttttcaat ggcttcacct gaatatggaa tggaaagaga acagcaggct attagtttat
    13441 cacccaatgt catttttgat cctgctggaa aggttatttg gaagcaaggg catgagcata
    13501 cgctgactat gatggaattc cgattattaa tgtatcttct tactgcaaaa gagtgtgctt
    13561 ctacgattga tcacattata gacagagtct ggggagtgga tgcttttact acgtctaata
    13621 cggtgtatgt gcacatccga aaattgagag agaaaataga agatgatcca agtcatccaa
    13681 aaattttggt aacatgtcat ggaatcggtt acaagttgaa tatatttcct aaaaacttgg
    13741 aggtggtcag ttgtgaagag acaactgcat tatactgatg cgcaaaaact acataatgaa
    13801 gtgagagatc gggatgaaag atggtttagt gcatgtgatt tctttctaat cagagctcca
    13861 ttactaccgc tagaccgata ttttcaggtg ttttcggatc aagatgtgga cagccagctt
    13921 actttggagg aaataactcg tcgattaaag ttgatatccc aagaagctgt tgttcaagaa
    13981 gccatatcat tagcctctcc gtccctaatg cagtttttac attacttgaa tgatggccat
    14041 gctttggatg ataaaggaga gctacaaaag tatgagaaga cgctgaacag cttttatcgg
    14101 tattttattc ggatgactac ccgaacgact ccatttgggt tgttttcagg agtggggcag
    14161 gggatttgcg ggaagactac cgatctggat attggtagct atcctaagca tctgaagaga
    14221 gccagacccg acatggaatg gatatataaa ctgattcaaa aaatagaagc tgatccggcc
    14281 atatttaatc aactaaaggt cttcctaaac aaaacggtta tgatcaaagg aaatcgagcc
    14341 aaattaccat tccgacctaa gcatggagca gcagaagctg atgattcggc agaaattttt
    14401 aattccattc ggtttactga cgttgttcga atgacgtttg aagctgctga acatccaatt
    14461 cgggtgatgg aactcaaaga aatactatta aaggcattcc ctgacgctac tttggaaatc
    14521 atatctgatt atttgcagca actagtagag caagagttta tcttgagcga gcttagacct
    14581 ccgttaatgg atcattcacc cttccattac atattcgaaa aaattagaaa actggacatt
    14641 tccgatcctt gggttcacat tttacacgaa attgatgcct tattacttca atataatcaa
    14701 tgtacaattg gagaaggaga gaaggtctac cggaaattat gtgacaaaat gctggatatc
    14761 atttctgtta aaacacctgt acaagttgat gttaaattgg ataaagatgt aactctgccg
    14821 aaacatgtac ttgatgaggt ttcattaggg gctgaagtca tgtgcaaatt atatgcatcc
    14881 cccaaaacgg acgaattgga tgaatatttg aatcgtttct tggaaaagta cggtgtgtat
    14941 caggaggttc ctattcatga actgtttgat gaggattggg gtctgggtat accggaaatg
    15001 tatcgttcaa atgaaaaaaa atcaatgggc atggaggcat ttaaacgcaa cgctgttctc
    15061 tttcaatggg tttcgaatgc catttctaat catgaaatag aactcgccct tacagatgaa
    15121 cagttagagc aactgatgat ttctgataac tacgacactt ccccagaatc aatggagatc
    15181 tattatagta tatttgctga ttctcctgaa aaagttgatt ctggagacta ttcgctttta
    15241 cttggagcca gtgctggctc gaatagagcg ggtaaaacct ttggacgttt tctggatatg
    15301 ttgagtgagg agtttgtaca aaaattctct gaaatatatg atcatcaccg atgctttcat
    15361 cccgatgcgt tattgtcaga gatggttttt atgccggaac aggggaaaat atctaatatc
    15421 tcattaagca aaaatttaat ggcatatgag attgtgtcgg gaacaacctc ttctaaagat
    15481 gaggaccata cgctctgtat tgatgattta gtggtgggtg ctactcatga tcgtttttat
    15541 gtcaagtcca gacgtttggg taaggaaata atccccttgc aaacacacat gctgaattac
    15601 aagctttcac cacatatatt cagatttcta acggatatta ccaataaaga gattggtacg
    15661 tggtcttatt ttgactgggg gccattagag caatcccctt ttttgccaag actagtatat
    15721 aaaaagatca ttattagtgc tgcgcagtgg aaactgagca aagcttcatt gaatatttca
    15781 gaatcatgcg agtccaaaga aggagaagca cttttccatg tgtggagaca acaatggaat
    15841 gtaccgcgtt atgtttacct aacgatgggg gataatcgcc ttttattaga cctatgcaac
    15901 cttttccata tcaaagaatt gctacatgag gtgagcaaga cacgtgaagg acaggaactt
    15961 cttcttaccg agtgtttggg taatcccttc cataccccag tacaggggac ggcaggaaga
    16021 tatatgggag aatttgtgtt tccactaaag aagaaaaaaa taaaggtgaa accgagtatc
    16081 cctagttcac aaaaccatat tgtttctcaa aacttcattg ctcatactcc ttccagcatt
    16141 catagaggca tatttccagg aggggagtgg ctatacctta aattgtacgg agtcaaggaa
    16201 agagagactg acctggtagg cataagccta gggcatctct taaaacagcc ggggtttaag
    16261 gattggagtc aaaaatttta ctttttgcga tacgttgatc ctgaacatca tatccgccta
    16321 aggtttcagg gagagcccga taagctatgg acagctggtt tggcgcagtt aaatcagtgg
    16381 gcagccgagt tacgtgaaga ggggctaata acgaatatgg tcatagatac ataccatcct
    16441 gaattggaga ggtatggagg acagacactt atggagctgg cagaacaggt ttttgacgtg
    16501 gatagtcaat gggtcatcgc ctatatgaag ggaattcgct ctaatgcttt caatctggac
    16561 atagagattg cggctgtgat gaacattatt cattatctga gtggttttgg tttaacgatt
    16621 caggagcaag tgaaatggct agaagagaga attgattgca agcctcatat gaaggcattc
    16681 agggatgtca aaaaaacatt gattaccgct gtagaatcga attatgaatg gattggacaa
    16741 gcagatacga acacacaggt tgctttctta gcgcttgtag aaaaaagaca ggctatgatt
    16801 cagcagtatg ctcaagcgat tatcctggct aaaaataatc acgagcttac caatcatcct
    16861 gatgatattt tgggcagtat cattcatatg catttgaatc gtctgcttgg tgtaaatagg
    16921 gagcgagaaa taaaatgtat ggctttagct aagcacacag tagctaacct tttgcatcgg
    16981 aaaggggtaa gctatgtcac agtctgatgg acaaaccaat gacctgatct ctttgtccta
    17041 taaaaatata tttcgtacct ttttattttg gcctcgtata ttcaggctgc tttgggacac
    17101 acatccttcc tttttgattg ctatactcat tacgaattta ttgaagggtg caattcctgc
    17161 tgtgatcctt ttaactacca gagaattaat caacagtgtc gtggccggag cgtcaggggg
    17221 aagctttcaa cctgttttta tagcttttgg cgtcttgatc ggtgtcaatt tgctgtacga
    17281 tctgatcaat attggcgaaa gcttttttcg taaaatgttt caaagccggc tatcgaacca
    17341 ggtaaatatc aaaattattg aaaaagcaca aaagatgtct ttgcagtcgt ttgaggatgc
    17401 agatgtgcaa aatatgcttc aacgtgctca gggagaggca gatttcaggc cgtttgaaat
    17461 atttactcaa atccttgcca ttattagcag tgttgtaacc ttattttcga cgggtgcgat
    17521 tctcatcgca tggagatggt gggcattctt attcattttt ctcattccat gcttatcatt
    17581 ttattctttt ttacgtatcg ggcaaagaga atttaatgtt cactttcaaa gagcaggaag
    17641 acaacgtgaa tcttggtatt tgtcgttttt agtgacaaga gataatagtt ttaaagaagt
    17701 gaaaatattt caattgggag actatctgcg aaaaagatat aaaacgatac tcgaagggtt
    17761 ttatcgcgag gataaagtgc tagcgattcg tagatcctat acttctcttg tatttcagat
    17821 tgtaaatcag ggtgcgtgtg catttattat tttcatggcc atacaagcca cttatgttgg
    17881 tcaaatttta gtggggaact tggtgagctt aattcagggt atcacgttaa cccagtcaac
    17941 atcgcagagc attgtacaag ggattttaag cttgtgtcaa aataatttgt atatcaagca
    18001 gctatttgac tttttggata tgccggaaga ggaaaaaata caaaaaacgg ttcagcaatt
    18061 gcctttgtcc actattcata gtattgaatt tcggaatgta tcgtttagat acccgaacac
    18121 ggaggagaat gccatttcta atgttagctt caagcttcat caaggagaga agctggccat
    18181 tgtagggaga aatggatcgg gtaaatcaac gatcgtgaag ttactaactc atctgtattc
    18241 cgattttgaa ggagaaatat taattaatgg atactctata catgaattgg ataaagacat
    18301 ttttagagaa aagataggcg ttgtttttca ggattttgta cattatgaga tggctgttag
    18361 agataatata ggctttggta atgtggcttc cagagaaaat gatgaggcta tttggacagc
    18421 tatagataag gcggggatta cagatttgat agtcggcctg cctgataaaa tgaatacctt
    18481 gcttggaaaa tggtttgaag atggacagca gctatctgga ggacagtggc agcgtattgc
    18541 aatagccagg gcttttatga gaaatgccga tatatatgtc ttggatgaac cgagctcttt
    18601 tttggatcca catgcggaga aagaggtttt tcaaaagttt gatcagctta tttatgagaa
    18661 aattggagtg tttatatccc acagattgtc ctccgcacgt atggcggata ccattatttt
    18721 aatggaggaa ggcagaattg tagaagcagg tagccatgaa cgcttaatgg atatagacgg
    18781 agtgtatgca gaaatgttca ggcttcaagc ctcctcgtat ctttcacaac gagaatgtga
    18841 ctttgaggaa gaagatctgt cgccctcgtt agtaaggacg acaggtggat cataagaaat
    18901 ggcagatgcc ctcctattgt aggagggtaa tttttatctt caccacaata gtcgaactac
    18961 agccatactc acaataccga taacgacggt agccagcagg tttttactcc acaaggcggt
    19021 cactagcgta ggaaagacag ccataagcac ttgcccatta agagtgactg aggattcggt
    19081 tcggacgagc aaattctcca tcacgagggc cgtgaatatg cagatgggaa tataggaaag
    19141 ccattgtagc actggtttag gaagcgccag cctttgcagc acgacaaagg gaatgatcct
    19201 tgggatggct gtgacaatca tggcaccgat aatgatatac aggacattgg gattaatgct
    19261 catttgtcgg ttaacactcc aatcgttgcg gtgatcatgg ttgctacaat gacggcgata
    19321 tgtgatggca cccaccaggc caaaaggtac atcagaacag ccatacatag cacaagcagc
    19381 agacgatgct tgagtttgga ggtctggaca ctttggagct gggaaataag cagggcaagg
    19441 aacatcgcag gcaaggcaaa gtccagacca aaagcctccg gccgggaaat ccagttcccg
    19501 agaacccctc ccgccacaca ggatacaatc caggcgagat aagctgtaat attaagtccg
    19561 ttcatccagc ggtcactgac ctgcccgcct ttagccaatt tatccgacgc tactccaaag
    19621 gattcgtccg tcaaaagagc gccgatgcct atgtttttcc acaatgaata tttagaaaag
    19681 taaggagcca gcgacgcact taacagcaga tgacgagcat tcacaatgaa tgtcgttaaa
    19741 ataatgacgg atggaggact ggctgcagcc agcatcgagc acataataaa ctgagaggct
    19801 ccggcgtata caagcgccga catgaaggca atttccatgg tgctaacccc tgatgaggca
    19861 cccacaatgc ctgccgcgaa cccaatacat acataaccga gcaatgtagg aatacaatct
    19921 ttaaccccat gtaaaaagct gagtgaatcg ggcttcgttc cgctcaactc cgaagctatg
    19981 gacattttaa ccttaccccc agtgtataaa ttttataata gtatataacg taagttgtaa
    20041 agtatcaata tattatacgt ttgtacgtta tgttgaataa tttctatagc gaacacacag
    20101 ggagaatgtt tattttattg ctttttagaa cttgacccta tgatctctat agtgaaaaga
    20161 aacttgcagt ctattatgca ctacaagcat ccacgatctg atttatgaag aattattcaa
    20221 actaccgatg ttattatgga aggacatttc agtacaagga tcgtgcagaa gtgattgtaa
    20281 aagaaggact tcaaaaagtg gccatactaa aacaagaagg atagagatga atatgaacag
    20341 atgtagagga caaggacgta tacctaatgg aatccgcgtt ggtgcttcag cccggtaagg
    20401 aagataaaga gcttcagcga aaaaagagca tcaacaaaat tgaaacgctt ccatcttagt
    20461 gttattataa ttttcataaa gagagatagg gggagggaga tgccaagtat taaagatgta
    20521 gctagcttag ctggcgtagc tgtaggaact gtatcccgag ttattaacaa ctcgggctct
    20581 gtaaaaccag atacacgcag aaaagtggag gaagctatac aagaactgaa ttattttcct
    20641 aatgaagtcg ctcgaaattt taagatgagg aaatccaaga tggtggcctt gctgcttcca
    20701 agtatttggc atcctttttt ttctgaactg gcttattaca ttgaggatga gttggatcgg
    20761 gaaggcttta agctcatgtt atgtaatagc ggcggcaagc ccgaaaagga actgtattat
    20821 ctggatatgc tacggcaaaa caaagtggct ggtattgtcg gcattactta caatgatata
    20881 gagaatagcg taagcaatga cattccgatt gtaagtattg ataggcactt caacaaaaaa
    20941 attacctgtg tgacctccga taattatgag ggagggcgtc tggctttgag ggagcttgtt
    21001 aaagtgggag cccagaaacc ggcttttatg ggaagcgtca cttccgtttt cagtgaaacc
    21061 atgaatcgga gaaaaggttt cattcatgag gcgcaaacat tgggagtcga ttatgtaatc
    21121 tacgagaagc ccgaccctat agtggatgac gatgcctatt ttaacgagtt cttaaatgag
    21181 catcgcgatg tggacggcat tttcgctatt accgatatgt tagccgccaa ctatatagaa
    21241 agagcacgca ggcagggcat tcgcgttcca gaggatgtaa aggttatcgg ctacgacggg
    21301 attcaggatc atccttattt tcatccgata ttgtctacaa tcaggcagcc agttgaggag
    21361 atggcacgta tgacaatcag actgctttat aagaaaatcg aaggtgaaac tttagatcag
    21421 caagtgtatc gtctccccat tgtcttcaag caaggcgaaa ctacataatt ttattgtgaa
    21481 aatattagct cattcggtcg attcatagta gggatctact aactgacgtt tttcttacag
    21541 caaattggaa acgtttcaaa agtgaaaaca tcctagttca agaaaggggg tgtaatggtg
    21601 aattcaagaa ctagcgagtc ggatcattct ggatcaagcc aaatcgaaaa atatggaacc
    21661 ggatcaaacg cgactattcc ttaaacattc aaacttcaaa cttttttctt ttggcagaag
    21721 aaagatatct cagttcttcc cgatatttcg ccacggttct gcgtgataga tgcaaacctt
    21781 cctttcccag cagggtagta agagcctgat ccgataacgg tttttgcttg tcctcatcat
    21841 ctatcaaatt tttgatacgc ttttttgcac tctccgatga agccgcatct ccgtcggctg
    21901 acgtcaagga ggaagtaaag aagaatttga gttcgaacaa tccgcgaggc gtctgtataa
    21961 atttattact gaccgccctg ctgaccgtgg attcgtgtaa gcccgtctta tcggcaatct
    22021 ccttttgggt gattggtttg aggaaataca cgccatgctc aaaaaaatcc tgctgctttt
    22081 ccacaatggc cttggcaacc cgtagaaggg tcagccgacg ttgcttcagg ctattgatca
    22141 gccattttgc cgtattcatc ttctcatgga taaaacgttt ggtttcacta ttcggtagat
    22201 cctgcatcat ttgccggtaa aaagggttga tctcaacccg cggcgcacta atgtcattaa
    22261 tcaggacaag atattccccg ttggcttttt cgaccgttat atctgctatg atgtattgct
    22321 gctctttatg agcaaatgct gcgcccgggc atggatttag cttgcgaatt cgatcggcca
    22381 tctgtataac ctcttgccta ctgatttcaa gagcatccgc aattttttgt atccgattgt
    22441 tcgccagatc ggccagatgg ttgcttacca ttctgactat gcattcatca tccatgccag
    22501 caagctggag ctggagaaga agacactctt ccaagctgta agaggcgatc cccggtggat
    22561 caaaactctg tatcaccaag agcatatcct caatttcggc tatgggaacg tccaatagtg
    22621 aggcgactgt tggaacatca agttctaaat atcccatttc gttcaaattg ccaatgaggt
    22681 accgtgccac catacgctgt gaatttgtaa gcccgcatac cagtccaagc tgcctgttca
    22741 gatgttcaaa cagggtatca ttcggattgg ggacaaaatc cagaaatgta acggggtttg
    22801 ctcgctggac cgatggatat ttttctccgc cacgataacg ttcaagcaga tctccttgat
    22861 ttttctgtga aaaccgctct gcttcttctt tgatactgcc tatggacata ttaaactccg
    22921 gcaaatcaat gactggatta ttgttcgctt gttcatgcag aaaggatatt aaatcagccg
    22981 aagaatattg caagatcgtg attgcttgtc gcaattcggg cgtcataacc agcttgaatc
    23041 cttgttcctg ttgtaatcca tatcgtatca ttgacttatt caaactcctt ttccatacat
    23101 ttctggtaca aattcacagt cagtcattta tgaaagatct acttctctaa gcctatgcaa
    23161 ttctcctgcc tagatgttaa cgttaccgag taattttatc tgatagaaac gattcataaa
    23221 caagccaaag cttgtcgtaa taagtaacaa gttattatgt gtgttgtatt tttggttata
    23281 tacactatct ttcttgtata ctcattcatt gaataacaaa atacactgga gctggaggaa
    23341 tcatttatgg aaacttataa aattgtctgc attgatattg acgggacgct gcttaactcg
    23401 gcgcatcaaa tcacggaagc aaccaaagaa accattctcc aggttataaa tgataagcag
    23461 attccagtgg ttcttgtctc tgcgcgaatg ccaaaagcaa ttattccatt gcagaagcat
    23521 cttggtattt ctgagcctct catatgctac agtggggcac ttgttataga taaacacggg
    23581 aacaagctga acacccgtta tatagataag aaaatgacac agcgtttgct tgatagcctg
    23641 gctgcctatg atcttcacgt aagcctgtat aaggatgatg agtggtatat tgagcaattg
    23701 gatgcatggg cgcttcaaga acgtgacatc accaatatcg agcctcgcat ttatagtttt
    23761 tctaagctta ccaatggttg gagggaagag actgatggaa ccagtaaaat tttgtgcatg
    23821 ggtgatcccg aagagatcag acgcgtcctt caagtattgc gacccgtata cggcgaagaa
    23881 gtaaatctct acttatccaa gcctacttat ctggaaatca tgtcaaaaaa ggcttccaaa
    23941 acggcagcca ttcaaattct gctaaaagag taccaactga aacaaagcga ttgtctggct
    24001 atgggtgaca actacaatga tatcgacatg ctggcctttg cgggacttgg cattgccatg
    24061 gaaaatgctc cccttgaggt caaagctgct gccaacaccg ttactctctc gaatgacgag
    24121 gatggagtag ctcatgcgct gaaaaaccat attctgttcc ctaaataagc aggttgaaat
    24181 caatttccaa tgactgattc aggctggagg aatacaggtg aaaagaatag ataagatttt
    24241 agagtatatt gccgaaagca ccaagaaaat ttccaaagag gctttatttg cgggggaagg
    24301 gattacggct gcggaaattg ctgatgatca aaagatgttg agaaacaatg tgagcaaaga
    24361 gttgaataat ctgctgcgtg acgatctaat ccttaaaatc aaaggaagac cggtcagatt
    24421 tctgcacaag cagattatcg aggacacctt tcgggttcgg ctgaaagaga aacaaattga
    24481 ggtcaaaagc atcaaagagg tattgctgcc tgaccaacag gtcgatccat tccatgcctt
    24541 gatcggtttc aggggcagca tgcgtaacca ggttgagcag gggaaggcag cgattctgta
    24601 tcctcctaga ggtctgcata ccctgatagt cgggcagacg ggtgttggaa aaactatgtt
    24661 tgccaggttg atgtaccatt atggcaagta tatgaagcgg ttttcagagc atgcgccatt
    24721 tatcgttttt aactgcgctg attatttcaa taacccccac ttgctacttt cccacatctt
    24781 tggtcacgtt aaaggggcgt ttacaggcgc tgatcatgaa aaagcagggc tggtggagaa
    24841 agctgacgga ggcatcctgt ttttggatga gattcaccgt ttacccccgg aaggccagga
    24901 aatgattttc tatttcatgg atactcacac ctataacaaa ttgggcgaaa cggatcgaaa
    24961 aagagatgcg agtgtgttat tgattggagc tacgacggag gatcccggat catccatgct
    25021 gaaaaccttc attaggcgca tacccatcac aatcaatatc ccttcccttc aggaacgtgc
    25081 tattgaggag caaatgctga ttttgaagca tttgtttgct aacgaggcca atagggtaaa
    25141 caagccgatt aggattgaat cagaggtagt aagagcactg atcggcagcg tcacctacgg
    25201 caatatcggc cagttaaagt cgaacatcca gctggtatgc gcgaaaggtt ttttaaacag
    25261 catacatgaa aacaaagaag aaataggact tgattttaaa aacctgccgg gaaatatccg
    25321 agatggtttg tttaatattg ataaaacgca atataagatg aaggaaatcg gatgtatttc
    25381 ctcgggccta tacattactc cagaaggaag aaaagctttg gatgaagagg ttgtttccga
    25441 gctgccgttt aacctttaca aattaattga agacaagatt ggcatgctga aggaagaagg
    25501 gctagacgac gcctacatcc acaggtttat tgctacggat gtcaatatcc atattaaaag
    25561 cttttataac cgtttttata acaccaaggg gagcagggaa cgaattctga aaattgtgga
    25621 caaagacatc cttgaattct ccgagcagat taaggaaatg gccaaaaagg aactaaaccg
    25681 aatttacagc gagagattcg tgtatgcttt cagtcttcat ttaagcgcct ttttcaagcg
    25741 caccagagag aaaaaatacg gtgatgcacg aatctatgaa ccgatgaatg accataatga
    25801 agagtacaga ctggcccaga ctatcaaaag tttgatcgaa tctaagttcg gtgtacatgt
    25861 accggaggcc gaaataactt atatggcgat tcttctgaaa tctgttgagg aggaacgaca
    25921 gggtagtgtg ggaattattg tggcagcaca cggcaccagt acagcgagca gcatcgtcgg
    25981 cgtcgtagac agcttgctgg gcagttctaa tctttgcgct gttgatatgc ccctcgatgt
    26041 cagtcctagg gaaattttgg agcttattat cgataaagta aagagcattg accgtggtag
    26101 aggcgtgttg ctgctggttg atatgggctc tttgctcaat cttgaagaaa ctattatgga
    26161 acgtgtggga atcaatgtaa agaccattga tatggtttca actccgctca cgctggaggc
    26221 tgtccgaaag gccagtgttt ttgacatggg gatagaggag atataccaat cgctaaagga
    26281 tttcagggga tataacaata gcagcgccgc agtgaaagta gttcataagg caattgtgac
    26341 ggtttgctcc tccggcaaag gtgcagcggt caaattgaaa gagtttgtgg agaaaattgt
    26401 ctgcgatttg acggatgagg aaatactggt tgtcccggca aacgtaaggg agttggataa
    26461 agtggtccag gatatgcggt ctaagcgaac aattcttgcc gtgattggag taaaacggcc
    26521 aagcgagccg gaaatcccgt ttattccctt ggaaaagctg attgaagcaa gcggtgagca
    26581 gacattgaga gagctactgc tgaataacaa acagatccct gctgtggatc aaagtgtagt
    26641 cgtcagggag ttatgcgagg aaagtctgaa agaatttatg acttatttga atccccacaa
    26701 agttctgggc atggtgatga gatttgtgca agagctggaa cttggattgg aagtcaaatt
    26761 tgattatgca acaaaagtcc aaatttctac tcacacagct tatgcgctgg aacgcatggt
    26821 tattcgcgat ggacttgttt atcaggggga agtgagaaag ctcgaccagc gcatattcga
    26881 ggtggtaaac cgttcatgca gcatatttgt ttctggtatg aatcttatac tttctgatga
    26941 cgaaaaatat tatatttgcg aaatgttgag cgaagtatat aactttattc cacagtaatg
    27001 gtcaaag
//
