LOCUS       NZ_AP023438            21427 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Micromonospora sagamiensis strain JCM 3310 chromosome, complete
            genome.
ACCESSION   NZ_AP023438
VERSION     NZ_AP023438.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora sagamiensis
  ORGANISM  Micromonospora sagamiensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Micromonosporales; Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 6930736)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014680085.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:12:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,941
            CDSs (total)                      :: 5,859
            Genes (coding)                    :: 5,751
            CDSs (with protein)               :: 5,751
            Genes (RNA)                       :: 82
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 108
            CDSs (without protein)            :: 108
            Pseudo Genes (ambiguous residues) :: 0 of 108
            Pseudo Genes (frameshifted)       :: 30 of 108
            Pseudo Genes (incomplete)         :: 88 of 108
            Pseudo Genes (internal stop)      :: 5 of 108
            Pseudo Genes (multiple problems)  :: 15 of 108
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:39:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4995583
            Orig. end                         :: 5017010
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023438.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017556
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21427
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="23"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21427
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21427
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11427](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11427)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(394..409)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            complement(623..1210)
                     /locus_tag="IGA62_RS22040"
                     /old_locus_tag="GCM10017556_43950"
     CDS             complement(623..1210)
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014453.5"
                     /locus_tag="IGA62_RS22040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_43950"
                     /product="sugar transferase"
                     /protein_id="WP_091462931.1"
                     /sec_met_domain="Bac_transf (E-value: 1.8e-55, bitscore:
                     185.6, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRGFDIVAAAVGLVLCAPLLLVIAVAIRWEDGGPVLFRQERTG
                     RRGRPFHIHKFRTMRAAPGPEVTADGDDRITRVGRLLRASKLDELPQLYDVLLGRMSLV
                     GPRPEVRRYVDHWPSVARWRILSVRPGITDPASIAYRDESAELARADRPEEYYVSVVLP
                     RKVELYVRYVETRSFLGDLLILARTVQAVLGR"
     gene            complement(1207..2361)
                     /locus_tag="IGA62_RS22045"
                     /old_locus_tag="GCM10017556_43960"
     CDS             complement(1207..2361)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013227.5"
                     /locus_tag="IGA62_RS22045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_43960"
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="WP_145819039.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1e-117,
                     bitscore: 391.9, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.2e-05, bitscore:
                     21.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQDRTLPFALPDVGEAEIAAVTSAIRSGWLSSGPLVREFEERFAA
                     YCGPGLTAVAMNSATAGLHLALEALGVGPGTEVLVPTWTFTATAEVVVHVGAVPVLVDV
                     DPATLNIDLDDAARKVTGRTVAVLPVHFAGQPVDATRLHEFARRHGVAVVEDAAHAFPA
                     ASGGVPVGAGPTAATVFSFYATKTITTGEGGMLVTRDPDLARRARVMRLHGFDRDGFDR
                     YRSDRPAWRYDVVEAGFKNNLTDPAAAMGLVQLARAESMRRRREEIAGRYRAAFAGLPL
                     DPPPPAPERDVHAWHLFVVRLRPDAPVDRDRFITEMSRLGVGCSVHFIPLHQHTHWRRR
                     LALTDDMFPVASREFERVVSLPLFSAMDDDQVDLVIRTVSKVLQ"
     gene            2480..3724
                     /locus_tag="IGA62_RS22050"
                     /old_locus_tag="GCM10017556_43970"
     CDS             2480..3724
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024831.5"
                     /locus_tag="IGA62_RS22050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_43970"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_145819038.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.8e-11,
                     bitscore: 42.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLGLLSQWFDPEPGPAALPGVLARGLVARGHDVQVLTGFPNWPT
                     GRLAPGHRITRRADEVADGVHVRRVALYPSHDGSALRRLATYGSFAASALVSGTPALRD
                     LDALWVSNSPITVAAPMWFVRYAHRVPVVLHVLDLWPDSVRASGFLDAGRRGRPLAERA
                     MHTWCAAMYRAAARVAYISPGVGELLARRGVPEEKLVHIPMWADETPTPPAPDLRAELG
                     ISADRVVLVYAGTLGEAQGLDVLVDACALVDDPRLLCLVAGSGTAERRLRDRASTLGLT
                     NLRFLGRLPRERMPALMAAGDVHYVGLRPGGMSAYTMPSKVQATLAAGRALLVAAEGDA
                     TTVARDSGAGITARPGDPGSVAAAIRESCQLGRQKLHLLGAAGREYYERTFSVAAGVAR
                     IEEALRAAVATGRRR"
     misc_feature    2783..2785
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3721..4353
                     /locus_tag="IGA62_RS22055"
                     /old_locus_tag="GCM10017556_43980"
     CDS             3721..4353
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="IGA62_RS22055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_43980"
                     /product="N-acetyltransferase"
                     /protein_id="WP_145819037.1"
                     /transl_table=11
                     /translation="MTGADLVDLAALADDDVPAAADLHLRAFPRFFLSSLGAPFLREFY
                     AGFVDDPDAVTVVSRGEDGRLVGVVVGTVTPDGFFRRLLRRRGHRMAVAAVRPALRDPR
                     AVGRLVRGIAYRGDVPVAARGALLSSICVDPAVAGGGRGRQLIDAWWRRVRERGVDDAY
                     LTTDAEGNDPVNAFYRRAGWTLVGEYATREGRRMNCYAVSAVPTADS"
     gene            4432..5406
                     /locus_tag="IGA62_RS22060"
                     /old_locus_tag="GCM10017556_43990"
     CDS             4432..5406
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013474758.1"
                     /locus_tag="IGA62_RS22060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_43990"
                     /product="DUF389 domain-containing protein"
                     /protein_id="WP_145819036.1"
                     /transl_table=11
                     /translation="MLHLRIIAPADRSEAVADLLAADPGVAHLAVLPGAARQPAGDLIL
                     CDVVRESADHVLHRLQELGVEARGGVSADDVELTLSSAAERAAREAPGHADDAVVWDEI
                     AAKTGEQTELSGTYLVLIVVATMLSGIAVLLDQPILIVGAMVVGPEFGPLAALCVALLR
                     RKPRIIARSVQALVVGFLIAIVLTILSTWALTAAGLVDRGMLLAERPVTDFIWRPDALS
                     WVVGLLAGVAGMLSLTSKKSGSLVGVLISVTTVPAAANAAVALAYGVWHEAGGSMLQLL
                     INICAIVVSGLLTLAVQQFWWWRVARRATGPVTASRRPRRAVG"
     misc_feature    complement(4478..4492)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(5369..5803)
                     /locus_tag="IGA62_RS22065"
                     /old_locus_tag="GCM10017556_44000"
     CDS             complement(5369..5803)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457938.1"
                     /locus_tag="IGA62_RS22065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44000"
                     /product="hypothetical protein"
                     /protein_id="WP_091462926.1"
                     /transl_table=11
                     /translation="MGEGDGRDWREQRQRAVRAHAAADERRRAAERAEAADLVAGFVAE
                     AIRRGLRPTPLVAGSYSGGGRYRTGLTGWYVDRAATRAVDVEGRFYLLTVPGGLRARLF
                     GATPRPHPAPLIVGEGGRDGDSVPLRELLSRRLDAGDDWP"
     gene            complement(5889..6830)
                     /locus_tag="IGA62_RS22070"
                     /old_locus_tag="GCM10017556_44010"
     CDS             complement(5889..6830)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012800.5"
                     /locus_tag="IGA62_RS22070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44010"
                     /product="hypothetical protein"
                     /protein_id="WP_145819035.1"
                     /transl_table=11
                     /translation="MADDIATALAGQAPIGRLTALEQRWSWELLVEATRVAVMRPVWRL
                     PGDEPAGLVTGSGGVGYRLPNVSTLAALTASCAPGVRVVKPGSRSSRSKDVGPGGLAAR
                     VGLPVADSPAAVSRALAGEQFALLDTDHLYPWLRLPEVFTVPYLAEAMHRASFLPCSAV
                     WKVNGVVEPDVGVHVERCRGSEVSRTLVVRGSTDLPDFVIDDVSTCGTTSMISISEATY
                     ETWSVEPEDVGLPRVAAADLIVARSTRVEELFAAILLGDAPASLIQLVAMSAGAVLLQA
                     GAVDTLAEGCATGLELLGSGVVAAKLSRLRQG"
     gene            complement(6865..7512)
                     /locus_tag="IGA62_RS22075"
                     /old_locus_tag="GCM10017556_44020"
     CDS             complement(6865..7512)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGA62_RS22075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017556_44020"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_145819034.1"
                     /transl_table=11
                     /translation="MMGKLHRLDGLVRHVLNQAPCQVFIETGTFHGESLEYAARLPFDR
                     IHSIELSPQLHRAAADRFAYDNRITVHHGDSARVLPEVLAGLHEPALIWLDAHYCFLDS
                     ARGPVDCPLLEEVEAIVAHERAAGLEHIVLIDDYHIFGTSPSSPWLVGDDITFVPEADW
                     SDITPERVRAGFCGGKQFHVWADTLFALPTWIQTADVAIPRDPFAEARPVAG"
     misc_feature    complement(7484..7499)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.43"
                     /tool="antismash"
     gene            complement(7644..8621)
                     /locus_tag="IGA62_RS22080"
                     /old_locus_tag="GCM10017556_44030"
     CDS             complement(7644..8621)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF046806.1"
                     /locus_tag="IGA62_RS22080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44030"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_145819033.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 5.4e-13, bitscore:
                     48.1, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 3.9e-13,
                     bitscore: 47.9, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVGVVGGGIAGRSHLFDLLCCPGFEPVAVCTTSVGSATRVARE
                     FGVGSAYSDVAAMIAQERMDGLVVAVPPGAGDRVLPVAAGCGLPLVIDKPGAASPAVLR
                     NVLATYPGLTGRTVVSYNRRYQAHVRALRSLLADGSLGALQRVHCTWTGPFRDRYASGD
                     TYRGSVRFGGGVLLDTVCHVVDTLLFLGLGPLEVKRARLDRGSRPADVAAEVRLRGGGG
                     RVSVTLSVGEGPEHWEIVVEGSAGRAHLVAAGLTVQTPAGARHVDGVDLGRPVEDLGRA
                     ERLGATVEEAEEVLRVLEHIRAAATARPWLPPRAKALGRLNGAC"
     gene            complement(8618..9997)
                     /locus_tag="IGA62_RS22085"
                     /old_locus_tag="GCM10017556_44040"
     CDS             complement(8618..9997)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="IGA62_RS22085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44040"
                     /product="B12-binding domain-containing radical SAM
                     protein"
                     /protein_id="WP_145819032.1"
                     /sec_met_domain="PF04055 (E-value: 3e-20, bitscore: 71.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFVNPHYPHDPFTLLLHPPLCYAYMSTHLKAAGHEVRHADLP
                     FLGNTLDALGPILADYRPDLVGVTSVAQSYCQALEIAAAVKNSGVDAKVVFGGPHVTFL
                     PTECLTRHADVDYVLLYDAEQSIVELCAAIGPGRAEEAALRKVSGLAFRTDAGSVALTP
                     PAPPLMALDELGRPDRSIFDLAPYLAYDYETVVMTARGCPSRCTFCSTTIAGRKPRWNS
                     PVHVVDEMEEVAELGFQSIFFGDDTFSGDPKRAIAISAEIRARGLDLPWTSNMRAQDAK
                     PAVLEAMREAGAYRVFMGFESIQKATLRLIKKGATPERMIEKARLVMDAGLELHASFII
                     GAPGDTDETLAATLDYIRLLNPTVATFNVMEPRPGTDVFSRPEQYGIEIPDRYWYESTG
                     WLYEPVCRTTTLTSTQIRDWVDQCYMEFCSPDFRAPERLATLDDATSQWRSSGLVEPVA
                     G"
     gene            complement(10001..11161)
                     /locus_tag="IGA62_RS22090"
                     /old_locus_tag="GCM10017556_44050"
     CDS             complement(10001..11161)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="IGA62_RS22090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44050"
                     /product="radical SAM/SPASM domain-containing protein"
                     /protein_id="WP_145819031.1"
                     /sec_met_domain="PF04055 (E-value: 1.3e-14, bitscore: 53.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.7e-10, bitscore:
                     39.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.1e-06, bitscore: 25.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLSEPADFQLPELKIPILVQLGLTYRCNLKCSHCYALYRRDRN
                     EFTFDELRKLTQDLYAAGAAAVVYSHGENMIRRDFHDVAALFRDLHFYQTLMLNGYYVR
                     QPADAQRLVDAGINRCMISIDSVDPEVHDRVRGKAGAFDTAMRAADLLLDTSMDTVGFS
                     STIDRHNYDDIEGIVQLALDRGVHAISFMQNRYNLRDIFDRALWRRYEEVCAEIYEIML
                     RYRGRLDIYTHDPFMLTLLDQRLDDNAARDAFIGANLCNVGTSMVSIDPVGNVTGCNFI
                     SEAVGNLREEPFAVIWDRLVDKYSDTRQPPTGACSGCGVLSACMGGCKAFHYIGKYDER
                     CGETRFGERHPHGLPVAAVEQIVPDRPAGAFLGMPRVGVRPPTAGA"
     gene            complement(11158..11427)
                     /locus_tag="IGA62_RS22095"
                     /old_locus_tag="GCM10017556_44060"
     CDS             complement(11158..11427)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04353.1"
                     /locus_tag="IGA62_RS22095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44060"
                     /product="HPr-rel-A system PqqD family peptide chaperone"
                     /protein_id="WP_145819030.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.8e-11,
                     bitscore: 42.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.9e-12, bitscore: 45.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNFAIADHVVCRQTNTDLRMLFDRQKGVMYELNETASSVVAILE
                     RSATTAEQISEELSEEFDAPRDEIRASVDEMLSDFENAGLVIRQ"
     aSDomain        complement(11164..11409)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IGA62_RS22095_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="8.40E-14"
                     /identifier="RREFam002.1"
                     /label="IGA62_RS22095"
                     /locus_tag="IGA62_RS22095"
                     /protein_end="88"
                     /protein_start="6"
                     /score="42.4"
                     /tool="antismash"
                     /translation="ADHVVCRQTNTDLRMLFDRQKGVMYELNETASSVVAILERSATTA
                     EQISEELSEEFDAPRDEIRASVDEMLSDFENAGLVIR"
     misc_feature    11623..11637
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.14"
                     /tool="antismash"
     misc_feature    complement(11651..11671)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.43"
                     /tool="antismash"
     misc_feature    complement(11726..11743)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.21"
                     /tool="antismash"
     gene            12097..12375
                     /locus_tag="IGA62_RS22100"
                     /old_locus_tag="GCM10017556_44070"
     CDS             12097..12375
                     /NRPS_PKS="Domain: PCP (5-71). E-value: 2e-19. Score: 61.5.
                     Matches aSDomain: nrpspksdomains_IGA62_RS22100_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="IGA62_RS22100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44070"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_186499956.1"
                     /sec_met_domain="PP-binding (E-value: 8.5e-14, bitscore:
                     50.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNTVEETVAEAWCDILGTADVHLDDDFFACGGDSMLAMMLLAQV
                     ERELDVELSLEGLFVDGSFGALLAACGRASRPKGADECRLPDAGFSR"
     aSDomain        12112..12309
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS22100_PCP.1"
                     /evalue="2.00E-19"
                     /label="IGA62_RS22100_PCP.1"
                     /locus_tag="IGA62_RS22100"
                     /protein_end="71"
                     /protein_start="5"
                     /score="61.5"
                     /tool="antismash"
                     /translation="EETVAEAWCDILGTADVHLDDDFFACGGDSMLAMMLLAQVERELD
                     VELSLEGLFVDGSFGALLAAC"
     gene            12581..13729
                     /locus_tag="IGA62_RS22105"
                     /old_locus_tag="GCM10017556_44080"
     CDS             12581..13729
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (3-235). E-value:
                     1.4e-20. Score: 65.5. Matches aSDomain:
                     nrpspksdomains_IGA62_RS22105_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IGA62_RS22105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44080"
                     /product="condensation domain-containing protein"
                     /protein_id="WP_190289195.1"
                     /sec_met_domain="Condensation (E-value: 1.9e-14, bitscore:
                     51.9, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARRLYDVAARQAALRITQVSLDAGGHTLFAPEPVIPLRHEVVDS
                     DEEFHALVRDCAGRRFGQDGGPLWTATVVERPGPAGGRRRTLCGVFDHHVADGRSLDLF
                     RAELTDALGSPSGPSTAGSYVDWLRWQHEQFPMGARGRVTPASEFWRRYLDGSAPEWAP
                     GFRFRTDEPLGKSYCRIRRKLFLSSEMLRRSAARSRVTPFILYLAAVASAISRHAEAED
                     VTVRTMTLGRPAPFLTTYGWMSSLVPVRVKGPGLADPVRAVPLAAAGWRQVLMWQATPR
                     EYLRQLFADGTGTTVAEQPTVDLNFNPFPHAPRPTDSAPGTESCETVAKELPRMLLCME
                     LEADDHFSLICMFPVERFPVADVRAFLDDLLAALAALLAGVE"
     aSDomain        12590..13285
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS22105_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.40E-20"
                     /label="IGA62_RS22105_Condensation_LCL.1"
                     /locus_tag="IGA62_RS22105"
                     /protein_end="235"
                     /protein_start="3"
                     /score="65.5"
                     /specificity="C activity: active"
                     /specificity="Active site motif: DHHVADG"
                     /tool="antismash"
                     /translation="RLYDVAARQAALRITQVSLDAGGHTLFAPEPVIPLRHEVVDSDEE
                     FHALVRDCAGRRFGQDGGPLWTATVVERPGPAGGRRRTLCGVFDHHVADGRSLDLFRAE
                     LTDALGSPSGPSTAGSYVDWLRWQHEQFPMGARGRVTPASEFWRRYLDGSAPEWAPGFR
                     FRTDEPLGKSYCRIRRKLFLSSEMLRRSAARSRVTPFILYLAAVASAISRHAEAEDVTV
                     RTMTLGRPAP"
     CDS_motif       12857..12913
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS22105_0001"
                     /evalue="1.40E-03"
                     /label="C3_LCL_132-143"
                     /locus_tag="IGA62_RS22105"
                     /protein_end="111"
                     /protein_start="92"
                     /score="11.4"
                     /tool="antismash"
                     /translation="HHVADGRSLDLFRAELTDA"
     gene            13829..15334
                     /locus_tag="IGA62_RS22110"
                     /old_locus_tag="GCM10017556_44090"
     CDS             13829..15334
                     /NRPS_PKS="Domain: AMP-binding (7-404). E-value: 1e-107.
                     Score: 352.2. Matches aSDomain:
                     nrpspksdomains_IGA62_RS22110_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="IGA62_RS22110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44090"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_145819027.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-113, bitscore:
                     377.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVVELVARSADQHPERTAVSWEHGSLSYRELNDRANRLANTLSE
                     RGLTHGAPVGVYTHRGADMIVALLGILKAGGACVPLDPQYPDERIRFMIDDARPSMLVT
                     HGDLDDRLGGVPVRRLVLDRQAGEIGRASAADPAVAPPPTQLAYVLYTSGSTGVPKGVE
                     IEHHALRDNAIKTARLHDLSADDVMLQFASLSFASSMGQIFAPLSVGAEVVVRGRQYSA
                     AGLLDYVRARDVTVLWLTPSMINYLVRHAETSSVALAIPRLRLLRSGGEALTTSLARRW
                     FALSDVPLLNVYGPTEAVQDVTACLLGEPPLVATIGRPIFDVEVFVLDDSREPVEPGTP
                     GELYFSTPGMARGYLNQPGLTSERFVDVVISGRALRLYRTGDLVRMLDSGELEYLGRRD
                     RQVKVQGHRIELGEIEERLTRHPAITAAVVVLSPSASGEARLVAYCMWSGGPGVREPDL
                     MRWCATALPAAMVPTRFVGVDTLPLTVNGKLDRRTLDSADSGP"
     aSDomain        13850..15040
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS22110_AMP-binding.1"
                     /evalue="1.00E-107"
                     /label="IGA62_RS22110_AMP-binding.1"
                     /locus_tag="IGA62_RS22110"
                     /protein_end="404"
                     /protein_start="7"
                     /score="352.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ARSADQHPERTAVSWEHGSLSYRELNDRANRLANTLSERGLTHGA
                     PVGVYTHRGADMIVALLGILKAGGACVPLDPQYPDERIRFMIDDARPSMLVTHGDLDDR
                     LGGVPVRRLVLDRQAGEIGRASAADPAVAPPPTQLAYVLYTSGSTGVPKGVEIEHHALR
                     DNAIKTARLHDLSADDVMLQFASLSFASSMGQIFAPLSVGAEVVVRGRQYSAAGLLDYV
                     RARDVTVLWLTPSMINYLVRHAETSSVALAIPRLRLLRSGGEALTTSLARRWFALSDVP
                     LLNVYGPTEAVQDVTACLLGEPPLVATIGRPIFDVEVFVLDDSREPVEPGTPGELYFST
                     PGMARGYLNQPGLTSERFVDVVISGRALRLYRTGDLVRMLDSGELEYLGRRDRQVKV"
     CDS_motif       14033..14074
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS22110_0001"
                     /evalue="1.10E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IGA62_RS22110"
                     /protein_end="82"
                     /protein_start="68"
                     /score="18.5"
                     /tool="antismash"
                     /translation="LGILKAGGACVPLD"
     CDS_motif       14267..14326
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS22110_0002"
                     /evalue="2.30E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IGA62_RS22110"
                     /protein_end="166"
                     /protein_start="146"
                     /score="32.3"
                     /tool="antismash"
                     /translation="AYVLYTSGSTGVPKGVEIEH"
     CDS_motif       14837..14923
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS22110_0003"
                     /evalue="2.40E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="IGA62_RS22110"
                     /protein_end="365"
                     /protein_start="336"
                     /score="42.2"
                     /tool="antismash"
                     /translation="PGTPGELYFSTPGMARGYLNQPGLTSERF"
     CDS_motif       15008..15073
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS22110_0004"
                     /evalue="2.20E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IGA62_RS22110"
                     /protein_end="415"
                     /protein_start="393"
                     /score="35.7"
                     /tool="antismash"
                     /translation="YLGRRDRQVKVQGHRIELGEIE"
     gene            15459..16427
                     /locus_tag="IGA62_RS22115"
                     /old_locus_tag="GCM10017556_44100"
     CDS             15459..16427
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020522304.1"
                     /locus_tag="IGA62_RS22115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44100"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_145819026.1"
                     /transl_table=11
                     /translation="MATNDIEVDELVRDYRRGGSTLRAVDSVSFSVARGELFGILGPNG
                     AGKTTTIKVLLTTLLPTSGRVSVLGHDVTTHVKQVRRRVGHVLGGDKGFYDRLTARQNL
                     TYFADLYEVPHRVQRTRIPELLEQVGLSERSRDRVEVYSRGMKQRLHIARSLVHDPQVL
                     ILDEPTNGIDPVGARELRELTAGLTRQGKTVLLTTHYMHEAEAMCERLVVLARGRIIAS
                     GTPSTVKRAVGIPRVTEIEVDGLEPERIAAIRGLAGVTSVEVDAVDARQLIQVRTEPDA
                     DCLQAVIQALGRVRIGRITTHDPTLEDAYVALVSRAPRDAS"
     gene            16424..17200
                     /locus_tag="IGA62_RS22120"
                     /old_locus_tag="GCM10017556_44110"
     CDS             16424..17200
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013245.5"
                     /locus_tag="IGA62_RS22120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44110"
                     /product="ABC transporter permease"
                     /protein_id="WP_145819025.1"
                     /transl_table=11
                     /translation="MTLLRFLATAWILNFRQMSTTKLYLFDAVILPVILATIAHRLAGD
                     VRDATAATVTTLGAAVLGMWAATLSGTGAAIGRMRSFGLLEPVVAAPLPLSAALASNAL
                     ASSALGIYAMAATLGWARLALGLPLHVASPTMLVAAAVTCVFSTAALGLVLSVSLVLYP
                     RAHAVSNIFEYPIWLLTGAWVPLGVMPDWVDTVSWVVGPAWGMKSIRAAVAGDVTAALS
                     ALVACAIVTALYWLFSVLLLRRVERLARERATLPLS"
     misc_feature    17186..17188
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17197..17979
                     /locus_tag="IGA62_RS22125"
                     /old_locus_tag="GCM10017556_44120"
     CDS             17197..17979
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013245.5"
                     /locus_tag="IGA62_RS22125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44120"
                     /product="ABC transporter permease"
                     /protein_id="WP_145819024.1"
                     /transl_table=11
                     /translation="MNGLRIVVVGGFLAYQGLFQWFSRRLILPTLVLRPMMQLAVFTVI
                     GAYLGSQPADFYAVGNAVQTTARASVYAATIVIAAERMNGTLITVLAAPAHPLLVFGGR
                     LLPPVLTGVASAALMMTVAMATTGVRLSWSATPSLLLLILLVSASCGAFGLVLGAIGLY
                     LRDVFFLPNVAVYAMMLLCGVNLTPAETSGVLALLGEALPLTHGLRAIRDVIAGRPVTT
                     AAWTTELLLVFAYGAAACVFLAYFARQARSKATLDLSS"
     gene            17989..20109
                     /locus_tag="IGA62_RS22130"
                     /old_locus_tag="GCM10017556_44130"
     CDS             17989..20109
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012905.5"
                     /locus_tag="IGA62_RS22130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_44130"
                     /product="GMC oxidoreductase"
                     /protein_id="WP_145819023.1"
                     /sec_met_domain="HAD_2 (E-value: 6.7e-06, bitscore: 24.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDIDTGVLVVGAGPVGVSLACRLARRGVATMLVEAAAPAAPTR
                     NVGLANWPTNLARSSGFGGSLRHWRGLCRPFAEEDLRERSWVSGSGWPVASADLAGFHR
                     DAARHLGVAAEYTIAAWQGAWQNDLPDMAALGLVPRVYALSPDGLALDNLRQLAVREEC
                     LSYLDGGRLVELYGDNASRSIHSALVRRSDGTRVRVRSRATVLAMGAIETARHLMHFGL
                     GNAWVGRSFLDHPHTLLGVLREADTARLEPLLETGFSAHGPARMLLHLTPEAQDRHAVP
                     AASLTAHTLTGTNALALLARTEQLPNPDSRLHLREAVDSDGVRLVDIAWNLHAADLRAL
                     RVLEESTAAAFRAHGLGRVVTGSCSSTSWPAGTVGACHHLGTTRMATSPDHGATDEFGR
                     LHGLDNLWIAGGAVFPTGTVVNPTLTAVALGLRTADRIAELVPVTGVSAQGVDLCEPGS
                     GRPDGAVERFIGLLGDRLASQARRLVVEDGLADAELLVLDLDGTLLRAHTEQLIAQVSR
                     FVARFGYDVDAPTLHALARNENMFGFLRPDDVGVLDLLFWDQFDESSMPPALHDGALAL
                     LQFARACGLTIAVCTARRAEAPVVEQLLRMLGCPPPSLVVSAGPAGAAKSEMLVALCER
                     AGVSTRRTVTVGDTVTDIVASRAAGIGLHISVGCGVASAAALAKAQPDVLVEDLGELLD
                     LWLNQQSGMSRA"
     misc_feature    complement(21274..21288)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
ORIGIN
        1 gggacctggc cgcgctgctc accggcttcg cgggcaccta ccacacgggg gaggtccccg
       61 acctgccgga ccggcacgcg gtgcggctgt tcaacaccta ccggtcgcac tgcttcccgg
      121 cgcactaccc ggtgccgctg acccggcggg ccgacgcccg gggtgagctg gtcgagacgg
      181 tgaaggtgca cggtggtggg ggacagacct tctgctccac cacccgcccc gcagcggtac
      241 gcggggagca cttccacctg gccaagctgg agcggttctg cgtgctccgg ggctcggcgg
      301 agatccggct ccgccgggtc ggcgacgaca cggtggtccg cttcccggtc agcggtgccg
      361 agccggtggt ggtggacatg ccgaccatgt gggcgcacca catcgtcaac accggcccgg
      421 acgacctgct cacgctcttc tggaccaacg aggtcttcga cccgggccgc cccgacacct
      481 ggcccgagcc ggtcgggcag ccggcccccg agccggcccc cgccctggcc ggctgaccgt
      541 ccagctgccc gcgaacaccg acaaccccgc cgacccactc cggtcggcgg ggttgtccgc
      601 gtggcgtccg gcccggcggg gctcagcggc ccaggaccgc ctgcaccgta cgggcgagga
      661 tcagcaggtc gccgaggaag ctgcgggtct cgacgtaccg cacgtagagt tccaccttgc
      721 gcggcagcac caccgagacg tagtactcct ccggccggtc cgcgcgggcc agctccgccg
      781 actcgtcgcg gtaggcgatc gacgccgggt cggtgatgcc cggccggacc gacaggatgc
      841 gccagcgcgc caccgacggc cagtggtcga cgtagcgccg gacctccgga cgggggccga
      901 ccaggctcat ccggccgagc agcacgtcgt agagctgcgg caactcgtcg agcttgctgg
      961 cccgcaggag ccggccgacg cgggtgatcc ggtcgtcgcc gtcggcggtg acctccgggc
     1021 ccggtgcggc gcgcatggtg cggaacttgt ggatgtggaa gggccggcca cgccgaccgg
     1081 tgcgctcctg ccggaacagc accggcccgc cgtcctccca ccggatcgcc acggcgatca
     1141 cgagcagcag cggggcgcag agcaccagcc ccaccgccgc ggcgacgatg tcgaaacctc
     1201 gtttgatcat tgcaggacct tgctgacggt acggatgacg agatccacct ggtcgtcgtc
     1261 catcgccgag aagagcggca ggctgaccac ccgctcgaac tcgcggctcg cgacggggaa
     1321 catgtcgtcg gtcagcgcga gccgacgacg ccagtgggtg tgctggtgca gcgggatgaa
     1381 gtggacgctg cacccgacgc cgagccggga catctcggtg atgaaccggt cccggtcgac
     1441 cggggcgtcc ggacgtagcc ggaccacgaa gaggtgccag gcgtgcacgt cccgctccgg
     1501 ggcgggcggg ggcgggtcca gcggcaggcc ggcgaacgcc gcccggtagc ggccggcgat
     1561 ctcctcccgt cgccgccgca tcgactcggc gcgggcgagc tgcaccagcc ccatcgccgc
     1621 cgccgggtcg gtcaggttgt tcttgaatcc ggcctcgacc acgtcgtacc gccaggcggg
     1681 ccggtcgctg cggtagcggt cgaagccgtc ccggtcgaaa ccgtgcaacc gcatcacccg
     1741 ggcccgtcgg gcgaggtcgg gatcccgggt gaccagcatg ccaccctcgc cggtggtgat
     1801 ggtcttggtg gcgtagaagc tgaagacggt ggcggcggtc gggccggcac ccaccgggac
     1861 accgccactg gcggcgggga aggcgtgcgc ggcgtcctcg accacggcca cgccgtgccg
     1921 gcgggcgaac tcgtgcagcc gggtggcgtc gaccggctgg ccggcgaagt gcaccggcag
     1981 gacggcgacg gtgcgtccgg tgaccttgcg cgcggcgtcg tcgaggtcga tgttcagggt
     2041 cgccgggtcg acgtccacca ggaccgggac cgcaccgacg tgcaccacga cctcggcggt
     2101 ggcggtgaag gtccaggtcg gcacgaggac ctccgtgccg gggcccaccc ccagggcctc
     2161 cagcgccagg tgcaggccgg cggtcgccga gttcatcgcg acggcggtga ggccgggtcc
     2221 gcagtacgcg gcgaaccgct cctcgaactc gcgcacgagc ggaccgctgg agagccagcc
     2281 ggaccggatc gccgacgtga cggcggcgat ctccgcctct ccgacgtccg gcagcgcgaa
     2341 gggaagagtg cggtcctgca tcccggtcct cctgttatgc gatttacgca ccaattgctg
     2401 cgactgagga taaactgcgc ctgtccgtta ggtgggctat tccggcttat tgcaccattt
     2461 ttggcagtga ggtgagggta tgcggctcgg cctgctcagc cagtggttcg acccggagcc
     2521 cggtccggcc gcactgcccg gcgtcctcgc ccgtggcctg gtcgcccggg gccacgacgt
     2581 gcaggtgctc accggttttc cgaactggcc caccggccgg ctcgcccccg gtcaccggat
     2641 cacccgtcgc gccgacgagg tcgccgacgg cgtccacgtc cggcgggtgg cgctctaccc
     2701 cagccacgat ggttcggccc tgcgccggct ggccacctac ggctcgttcg ccgcctccgc
     2761 gctcgtctcc ggcacacccg cgttacgcga cctcgacgcg ctctgggtga gcaactcgcc
     2821 gatcaccgtc gccgcgccga tgtggttcgt ccggtacgcc caccgggtgc cggtggtgct
     2881 gcacgtgttg gacctgtggc cggacagcgt ccgggccagc ggcttcctcg acgccggacg
     2941 ccgtgggcgt ccgctcgccg aacgggcgat gcacacctgg tgcgcggcga tgtaccgggc
     3001 cgccgcccgg gtcgcctaca tctcgcccgg cgtcggcgaa ctgctggccc ggcgtggcgt
     3061 gccggaggag aaactcgtgc atattccgat gtgggcggac gagaccccga cgcccccggc
     3121 tcccgacctg cgcgccgaac tcggcatctc ggcggaccgg gtggtgctgg tctacgcggg
     3181 caccctcggc gaggcgcagg gcctcgacgt gctggtcgac gcgtgtgccc tggtcgacga
     3241 cccccggttg ctctgcctgg tcgccggctc cggcacggcc gagcggcggc tgcgggaccg
     3301 cgcctcgacg ctcggcctga ccaacctccg cttcctcggc cggctgcccc gggaacggat
     3361 gcccgccctg atggccgcgg gcgacgtcca ctacgtcggt ctccggccgg gcggcatgtc
     3421 ggcgtacacc atgccgagca aggtgcaggc caccctcgcc gccggtcggg ccctgctggt
     3481 ggcggcggag ggggatgcca ccacggtggc gcgggacagc ggcgcgggga tcaccgcccg
     3541 acccggcgac cccggctcgg tggccgccgc catccgcgag tcctgccagc tcggtcggca
     3601 gaagctgcac ctgctgggcg cggcgggccg ggagtactac gagcggacct tctccgtcgc
     3661 cgccggggtc gcccggatcg aggaggcgct gcgggcggcc gtggcgaccg ggcggcgtcg
     3721 atgaccggag ccgacctggt cgacctcgcc gcgctggccg acgacgacgt gcccgccgcg
     3781 gctgacctgc acctgcgggc cttcccccgg ttcttcctgt ccagcctcgg cgcgccgttc
     3841 ctgcgcgagt tctacgccgg gttcgtcgac gacccggacg cggtcaccgt ggtgtcgcgg
     3901 ggcgaggacg gccggctggt cggggtcgtg gtcggcaccg tcacgcccga cggcttcttc
     3961 cgccggctgc tgcgtcggcg cggccaccgg atggccgtcg ccgccgtccg tcccgccctg
     4021 cgcgacccgc gcgccgtcgg gcgcctggta cgcggcatcg cgtaccgggg ggacgtcccg
     4081 gtggcggcgc gtggggcgct gctcagctcg atctgcgtcg acccggcggt ggccggcggt
     4141 ggccggggcc ggcagctgat cgacgcgtgg tggcgacggg tacgggaacg cggggtggac
     4201 gacgcctacc tgaccaccga cgccgagggc aacgacccgg tcaacgcctt ctaccgccgg
     4261 gccggatgga ccctggtggg ggagtacgcc acccgggagg gccggcggat gaactgctac
     4321 gccgtctcgg ccgttccgac cgccgattct tgacgcgtcg gatgtgaccc ctgacgggta
     4381 gagtgctgcg gccggcggca ggtacgccgc ccgaccgcag ggagcccgtc cgtgctgcac
     4441 ttgaggatca tcgcaccggc cgaccggtcc gaggcggtgg ccgatctgct cgccgccgac
     4501 ccgggcgtgg cccacctggc cgtcctgccg ggagccgccc gccagccggc cggcgacctg
     4561 atcctctgcg acgtggtccg ggagagcgcc gaccacgtgt tgcaccgcct ccaggaactc
     4621 ggcgtggagg cccggggcgg ggtcagcgcc gacgacgtcg agctgaccct ctcctcggcc
     4681 gccgagcggg ccgcccggga ggccccgggg cacgccgacg acgccgtcgt ctgggacgag
     4741 atcgccgcca agaccggcga gcagaccgaa ctgtcgggca cctatctggt gctgatcgtc
     4801 gtggccacca tgctctccgg catcgcggtg ctgctggacc agcccatcct gatcgtcggc
     4861 gcgatggtgg tcggccccga attcgggccg ctcgccgcgc tctgcgtcgc cctgctgcgc
     4921 cgcaagcccc ggatcatcgc ccggtcggtg caggccctgg tggtcggctt cctgatcgcg
     4981 atcgtgctca ccatcctgag cacctgggcg ctgaccgccg ccggcctggt cgaccggggg
     5041 atgctgctcg ccgagcggcc ggtgaccgac ttcatctggc gtcccgacgc cctctcctgg
     5101 gtggtcggtc tgctcgccgg ggtcgccggc atgctctcgc tcacctcgaa gaagtccggc
     5161 agcctggtcg gcgtgctgat ctcggtgacc acggtgccgg ccgccgcgaa cgcggcggtc
     5221 gccctggcct acggggtgtg gcacgaggcg ggcggctcga tgctgcaact tctgatcaac
     5281 atctgcgcga tcgtggtgtc cgggctgctc accctggccg tgcagcagtt ctggtggtgg
     5341 cgggtggccc gacgcgccac cggaccggtc acggccagtc gtcgcccgcg tcgagccgtc
     5401 ggctgagcag ttcccgcagc gggacggagt caccgtcccg gccgccctcc ccgacgatca
     5461 gcggggcggg gtgcgggcgc ggcgtcgccc cgaacagccg ggcccgcagg ccacccggca
     5521 cggtcagcag gtagaaccgc ccctcgacgt ccaccgcccg cgtcgcggca cggtcgacgt
     5581 accagccggt caggccggtg cggtaccgcc cgccgccgga gtaggaaccg gccaccagcg
     5641 gggtcggccg cagtccgcgc cggatcgcct cggcgacgaa cccggcgacc agatcggcgg
     5701 cctcggcccg ctcggcggcg cgtcgccgtt cgtccgcggc ggcgtgcgcc cgcaccgcac
     5761 gctgtcgttg ctcccgccag tcccggccgt cgccctcacc cacgaccccg acggtacgcc
     5821 gccggtcgtc cgctggcggc gcgggccttg cgggccgtcg gcctgcgcca ccgggcgtcg
     5881 ccgtccggtc agccttgccg aagccggctc agcttggcgg cgaccactcc ggaacccagc
     5941 agctccaggc cggtcgcgca gccttccgcc agggtgtcca cagcacccgc ctgtagcagc
     6001 acggcaccgg cagacatggc cacgagctgg atgagtgagg caggcgcatc acccagcaga
     6061 atcgcagcga acagctcctc gacccgggtc gaccgcgcca cgatcagatc tgcggcggcc
     6121 acccgcggca ggccgacgtc ctccggttcg acggaccatg tctcgtacgt cgcttccgaa
     6181 atggagatca tcgacgtggt gccgcaggtg ctgacgtcgt cgatgacgaa gtcgggcagg
     6241 tcggtgctgc cacggacgac cagagtccgg ctcacctcgg aaccgcggca tcgttcgacg
     6301 tgcacgccga cgtccggctc gacgaccccg ttgaccttcc acaccgccga acacggcagg
     6361 aaggacgctc ggtgcatggc ctccgcgagg tacggaacgg tgaacacctc gggcagccgc
     6421 agccacggat agaggtggtc ggtgtcgagc agcgcgaact gctcgccggc cagggcgcga
     6481 ctgaccgcgg ccggcgagtc cgccaccggc aggcccaccc tggcggcaag tccgccaggg
     6541 ccgacgtcct tggaccggct ggaccgtgaa cccggcttca ccacccggac cccgggagcg
     6601 caggacgcgg tcaacgcggc cagcgtggac acgttgggca gtcgatagcc aaccccaccg
     6661 cttccggtca ccaggccggc cggctcgtcg ccgggcagcc gccacaccgg ccgcatcacc
     6721 gcgacccggg tcgcctcgac cagcagttcc cacgaccagc gttgttccag cgccgtgagc
     6781 cggccgatgg gagcctgccc ggccagggcc gtggcgatgt cgtcagccac cgccgcgacg
     6841 tcggccggcg ggagggccga ccggtcaacc ggcaacggga cgggcctcag cgaacgggtc
     6901 gcgcggtatc gcgacgtcgg ccgtctgaat ccaggtggga agggcgaaca gcgtgtccgc
     6961 ccagacgtgg aactgcttcc cgccgcagaa gcccgcgcga acccgctccg gggtgatgtc
     7021 gctccagtcc gcctcgggga cgaaggtgat gtcgtcgccc accagccatg gcgaggaggg
     7081 agacgtgccg aagatgtggt agtcgtcgat gaggacgatg tgctcgagcc cggcggcacg
     7141 ctcgtgcgcg acgatcgcct cgacctcttc cagcagggga cagtccacgg gaccccgtgc
     7201 gctgtccagg aagcagtagt gtgcgtcgag ccagatcaat gcgggctcgt gcagtccggc
     7261 gagcacctcg ggcaggacgc gggccgagtc gccgtggtgc acggtgatcc ggttgtcgta
     7321 cgcgaaccgg tcggcggcgg ccctgtgcag ctgcggggag agttcgatcg agtggatccg
     7381 gtcgaagggc agccttgcgg cgtactccag gctctcgccg tggaaggtgc ccgtctcgat
     7441 gaagacctga catggcgcct ggttcaggac gtgccgaacg aggccgtcca gtcggtgaag
     7501 tttgcccatc atgttcctct tcgtagtggt cactgatgcg aacccgggcg gctgactcgg
     7561 cgtggaccgc ccgcaggctg gtccgggggc acgtcgacca ggagggcgtt tccggcgaat
     7621 cgccgtcgcc ggtggtccct gggtcagcag gccccgttga gccggccgag cgccttggcc
     7681 cgcggtggca accagggccg tgcggtcgcg gcggcccgga tgtgctcgag cacacggagc
     7741 acctcttcgg cctcctcgac ggtagcgccg aggcgttcgg cccgccccag atcctcgacc
     7801 gggcgcccga ggtcgacgcc gtcgacgtgt cgggcacccg ccggggtctg cacggtgagt
     7861 ccagccgcca ccaggtgcgc ccgccccgcc gagccctcga ccacgatctc ccagtgctct
     7921 gggccctcac cgacgctcag cgtcaccgac acgcgcccgc cgccaccgcg gagacggacc
     7981 tcggccgcca cgtcggcggg ccggctgccc ctgtcgagcc gcgcccgctt cacctccagg
     8041 ggacccaggc ccaggaagag cagcgtgtcg acgacatggc acacggtgtc gagcagcacg
     8101 ccgccgccga acctcaccga tccgcggtag gtgtcgccgc tggcgtaccg atcgcgaaac
     8161 ggtccggtcc aggtgcagtg cacgcgctgg agggcgccca ggctcccgtc ggcgagcagc
     8221 gaccgcaatg cccgcacgtg cgcctggtac ctgcggttgt acgacaccac cgtccggccg
     8281 gtgagtccgg ggtacgtcgc caggacgttt cgcagcacgg cgggcgacgc agcgcccggc
     8341 ttgtcgatga ccagcggcag gccgcaaccg gccgccaccg gcagcacgcg gtcgccggcc
     8401 ccgggtggca cggcgaccac caggccgtcc attcgctcct gcgcgatcat cgccgcgacg
     8461 tcgctgtacg ccgatccgac cccgaactcg cgtgcgaccc gggtcgcgga gccgacggac
     8521 gtggtgcaca ccgcgacggg ctcgaacccg gggcagcaga gcagatcgaa gaggtgggat
     8581 ctaccggcta tcccgccgcc caccacccct actcggatca tcccgccacc ggctcgacca
     8641 ggccggacga acgccactgg ctggtcgcgt cgtccagcgt cgccaggcgc tccggcgccc
     8701 ggaagtcggg gctgcagaac tccatgtagc actggtcgac ccagtcacgg atctgtgtcg
     8761 aggtgagcgt cgtcgtacga cacaccggct cgtacagcca gccggtcgac tcgtaccagt
     8821 accggtccgg gatctcgatg ccgtactgct ccggccggct gaacacgtcc gtccccggcc
     8881 gcggttccat gacgttgaac gtggccacgg tggggttgag cagacggatg tagtccagcg
     8941 tcgcggccag cgtctcgtcg gtgtccccgg gtgccccgat gatgaacgac gcgtgcagtt
     9001 ccagtcccgc gtccatgacg agcctggcct tctcgatcat gcgctccggg gtggccccct
     9061 tcttgatcag acgtagcgtg gccttctgga tcgactcgaa gcccatgaac acgcggtacg
     9121 cgcccgcctc gcgcatcgcc tccagcactg cgggtttggc gtcctgggcc cgcatgttgc
     9181 tggtccatgg caggtcgagg ccacgggcgc ggatctccgc cgagatggcg atggcccgct
     9241 tgggatcgcc ggagaaggtg tcgtcaccga agaagatcga ctggaagccg agttcagcga
     9301 cctcctccat ctcgtcgacg acgtggacgg gcgagttcca ccgtggtttg cggccggcga
     9361 tcgtggtcga gcagaacgta cagcggctcg gacatccgcg cgcggtcatc acgaccgtct
     9421 cgtagtcgta ggccagatag ggcgcgaggt cgaagatcga ccggtccggc cggcccagct
     9481 cgtcgagtgc catgagcggc ggcgcgggcg gggtgagcgc gacactgccc gcatccgtgc
     9541 ggaaggccag cccggacacc ttccgcaacg ccgcttcctc cgcccgcccc gggccgatcg
     9601 ccgcacacaa ctccacgatc gactgctcgg cgtcgtagag caggacgtag tcgacgtcgg
     9661 cgtgccgggt caggcattcg gtgggcagga acgtcacgtg aggcccaccg aacacgacct
     9721 tcgcatcgac accgctgttc ttgaccgctg ctgcgatctc cagcgcctga cagtacgact
     9781 gagccaccga ggtgaccccg accaggtcgg gccggtagtc cgccagtatc gggcccagcg
     9841 cgtcgagcgt gttgccgagg aacggcagat ccgcgtggcg cacctcgtga ccggcggcct
     9901 tgagatgtgt cgacatgtag gcgtagcaga gcggcgggtg cagcagcaac gtgaaggggt
     9961 cgtgcgggta gtgcggattg acgaagagca cgcgcacgac tcacgctccc gcggtgggcg
    10021 gacggacgcc gacgcgcggc atgccgagga acgctccggc ggggcgatcg gggacgatct
    10081 gttccaccgc ggccaccggc aggccatggg ggtgcctctc gccgaaccgg gtctcgccgc
    10141 accgctcgtc gtacttgccg atgtagtgga aggccttgca gcctcccatg caggcggaca
    10201 gcacgccgca tcccgagcag gcgccggtcg gcggctggcg cgtgtcggag tacttgtcga
    10261 ccagccggtc ccagatgacg gcgaagggtt cctcacgcag attgccgacg gcctcggaga
    10321 tgaagttgca gccggtcaca ttgcccaccg ggtcgatcga caccatgctc gtgcccacgt
    10381 tgcagaggtt cgcgccgatg aaggcgtccc gggcggcgtt gtcgtccagg cgctgatcca
    10441 gcagcgtcag catgaacggg tcatgcgtgt agatgtccag tctgccgcga taccgcagca
    10501 tgatctcgta gatctccgcg cagacctcct cgtagcggcg ccagagcgcc cggtcgaaga
    10561 tgtcgcgcag gttgtaccgg ttctgcatga agctgatcgc gtgcacgccc cggtcgagag
    10621 cgagttggac gatgccctcg atgtcgtcgt agttgtgccg gtcgatggtg gacgagaagc
    10681 cgaccgtgtc catcgaggtg tcgaggagga gatcggccgc ccgcatggcc gtgtcgaagg
    10741 cgcccgcctt gccgcggacc cggtcgtgca cctcgggatc gacgctgtcg atggagatca
    10801 tgcaacggtt gatgccggca tcgaccagcc gctgggcgtc cgccggctgg cggacgtagt
    10861 agccgttcag catgagcgtc tggtagaagt gcaggtcacg gaagagcgca gcgacgtcgt
    10921 ggaagtcccg gcgaatcatg ttctcaccgt gcgagtagac gacggcggca gccccggctg
    10981 cgtacagatc ctgggtgagc ttgcgcagct cgtcgaaggt gaactcgtta cggtcccggc
    11041 ggtagagcgc gtagcagtgc gagcacttca gattgcagcg gtacgtcaac cccaactgta
    11101 cgaggatcgg gatcttcagc tccggaagtt ggaaatccgc aggctcggac agtgtgctca
    11161 ttggcgaatc accagcccgg cgttttcgaa gtccgacagc atctcgtcga cgctcgcgcg
    11221 gatttcgtcc cggggggcgt cgaactcctc ggagagttcc tcggagatct gctcggccgt
    11281 ggtggcggac cgttcgagaa tggcgaccac actggatgcc gtctcgttca actcgtacat
    11341 gacgcccttc tggcgatcga agagcatccg gaggtcggtg ttggtctggc ggcagacaac
    11401 gtggtctgcg atggcgaagt tctgcatgag tggatccccg tgttcttacc cgtgatggtc
    11461 gcgcccccgg tggggcgaca gactctgccc gacagtgccg caggcaaccg attcaaccga
    11521 tgtgccgggc agtcgcctgc ggcaccgtac tcagggacta gcagtgcgta cggacgttac
    11581 gagcacgcca ctgcggccga cgccacgact tcttggcagc cttgatcgac attttccacc
    11641 tcccccgtgt catcgacccg aagctatttt tcgggcgacc gggttcgacg gtaactcggt
    11701 tcgcagtcgg ggacggtccc ggtaggtaac gaaacgataa cagacattga cgagagtgtt
    11761 ctagattggg ggaggcgtca gtttgggcgg agatgaaacc gcaggtgaag accctgatgg
    11821 tggggcatgg tgacgacggt gtcgggggtg cgcacccggc acgtcgagcc cgatcggcac
    11881 cggattcgag cccgatttcg gcggcggtgg aaccgcaggt gtgtcaaccc gggatcgatt
    11941 ccggccgggc ctcgggcggt gtcgggtgcg ccgcgagctg aggtgtcagc gagccgcgac
    12001 cacgctccac gaaagaccct gtggtgcccc gggggattga cagacgagtg gcgttgtggc
    12061 ggaatgagcc gcagaaagtc cagaagggta cgggggatgg acaacacagt ggaggaaacc
    12121 gttgccgagg cgtggtgtga catcctcggc acggccgatg ttcacctaga cgacgacttc
    12181 ttcgcctgtg gcggagactc catgctcgcc atgatgttgc tcgctcaggt ggagcgtgag
    12241 ctggatgtcg agctgtcctt ggaggggttg ttcgtcgacg gctctttcgg tgccctgctg
    12301 gcggcgtgtg gccgggccag ccgtccgaaa ggtgctgatg aatgccggtt gccggatgcc
    12361 gggttctcgc gatgagcctc tcgcggactc cgttttcctg ccgcccggga gaagcgcgga
    12421 ccgacgacgg cgaagggacg ggtgggtgat tcccggagcg gccgggtcgc cggtgcgcgg
    12481 ccctatctcg tggcagcagc acacccggct cacgtatcgg caaccgttgt ccaatctcga
    12541 tgtcctggtt gatctgccgg acggcatgga aaccgggcac gtggcacgga gactgtacga
    12601 cgtcgccgca cgccaggcgg cgctccggat cacgcaggtg tccctcgatg ccggcggaca
    12661 cacgctcttc gcgccggaac cggtcattcc gctgcgtcac gaggtcgtcg actcggacga
    12721 ggagttccac gcgctggtca gggactgtgc cggaagacgt ttcgggcagg acggcggacc
    12781 gctgtggacc gccaccgtcg tcgaacggcc cggtccggcc gggggacgca gacgcaccct
    12841 gtgcggcgtg ttcgatcacc acgtcgccga cggacgcagc ctcgacctct tccgggccga
    12901 gctcaccgac gcgctgggat caccgtcggg gccgtccacc gccgggtcgt acgtcgactg
    12961 gctcaggtgg caacacgagc agttccccat gggcgcccgc gggcgcgtga ccccggcgag
    13021 tgagttctgg cgtcggtacc tcgacggctc ggcccccgaa tgggcgcccg gcttccggtt
    13081 ccgcaccgac gaaccgctgg ggaagagcta ctgcaggatc cggcggaaac tgttcctctc
    13141 ctcggagatg ctgcgcaggt ccgccgcccg ttcgcgggtg accccgttca tcctctacct
    13201 ggcggccgtc gcgtcggcga tctcgcgcca tgccgaggcc gaagacgtga cggttcgtac
    13261 gatgaccctg ggcagaccgg ccccgttcct caccacgtac ggatggatgt cgagcctcgt
    13321 tccggtcagg gtgaagggcc ccggactggc cgacccggtt cgcgccgtgc ccctggccgc
    13381 ggccggctgg cgccaggtgc tgatgtggca ggcgacgccg cgggaatacc tccggcagct
    13441 cttcgccgac ggtaccggga cgacggtcgc ggagcagccg accgtcgacc tcaacttcaa
    13501 cccgttcccg cacgccccac gtcccaccga cagcgcgccc ggcaccgagt cctgcgagac
    13561 ggtggcgaag gaactgcccc gcatgctgct gtgcatggag ttggaggctg acgaccactt
    13621 cagcctgatc tgcatgttcc cggtcgaacg gttccccgtc gccgacgtgc gggccttcct
    13681 cgacgacctg ctggccgcac tggccgcact tctggcgggc gtggaatagc gtgccggcac
    13741 gctgcggcgc tctggcaccg gagcgacggc gcgcggccat ggtgcacgtc gcaggcagga
    13801 gggcgtcgga cgagaggcag gagcaggcat gaccgtcgtg gagctcgtgg cccgaagtgc
    13861 tgaccagcac cccgagcgca ccgccgtgag ctgggaacac gggtctctgt cgtaccggga
    13921 gctgaacgac cgggccaacc ggttggcgaa cacgttgtcg gagcgcggcc tgacgcacgg
    13981 ggcgccggtc ggcgtctaca cgcaccgcgg cgccgacatg atcgtcgccc tgctcgggat
    14041 cctcaaggcg ggcggcgcct gcgtgccgct cgatccgcag tatcccgacg agcggatccg
    14101 cttcatgatc gacgacgcgc ggccgtcgat gctggtgaca cacggcgacc tggacgaccg
    14161 gttggggggc gtgcccgtgc gacgcctcgt cctggatcgg caggcgggcg agatcggcag
    14221 ggcgtcagcg gcggatcctg cggtcgcgcc gccgccgacc cagctcgcct acgtcctcta
    14281 cacctcggga tccaccggtg tgcccaaggg agtggagatc gaacaccacg ccctccgtga
    14341 caatgcgatc aagaccgccc ggctccacga cctgtcggcg gacgatgtga tgctgcagtt
    14401 cgcgtcactg tcgttcgcgt cgtcgatggg gcagatcttc gctccgctgt cggtgggtgc
    14461 cgaggtggtg gtgcgcggcc gtcagtacag cgccgccggt ctcctggact acgtccgggc
    14521 ccgcgacgtc acggtgctgt ggctgactcc ctccatgatc aactacctcg tgcggcatgc
    14581 cgagacgtcg tcggtcgcgc tcgccatccc gcgacttcgg ttgctgcgca gcggcggcga
    14641 ggctctgacc acctcactgg cgcggcgctg gttcgcgttg agcgacgtcc cgctactcaa
    14701 cgtctatgga cccacggagg ccgtgcagga tgtcacggcc tgcctactcg gcgagcctcc
    14761 gctggtggcc accatcggca gaccgatctt cgacgtcgag gtcttcgtgc tggacgactc
    14821 ccgagagccg gtcgagccgg gcacgccggg cgagctgtac ttcagcacgc ccggcatggc
    14881 ccggggttac ctgaaccagc cgggtttgac gagcgagcgc ttcgtcgacg tcgtcatcag
    14941 cgggcgcgca ctgcggctct atcgcacggg cgacctggtg cggatgctgg acagcggcga
    15001 actggagtac ctcggccgtc gggaccggca ggtgaaggtg cagggccacc gcatcgaact
    15061 cggcgagatc gaggagcggc tgacgaggca tccggccatc accgcggccg tggtcgtcct
    15121 gtcgccgagc gcgagcggcg aggctcggct cgtcgcgtac tgcatgtggt ccggcgggcc
    15181 gggtgtgcgc gagccggacc tcatgcggtg gtgcgcgacg gcgcttcccg cggccatggt
    15241 gcccaccaga ttcgtcggcg tggacacgct tcccctgacc gtcaacggca agctcgaccg
    15301 gcggacgctg gactccgccg actccggacc ctgaagctgc cacaccgcgc gcaccgccga
    15361 ggcgccgctg cgtccccgga ccgacgccgg acggtcgcac ctccgggaag caggacatcc
    15421 cgtggaactc gccgagctgc aacgagaggc cgaccaccgt ggcgaccaac gacatcgaag
    15481 tggatgaact cgttcgcgac taccgccgcg gcggcagcac gctgcgcgcc gtcgactccg
    15541 tctccttctc cgtcgcgcgt ggagaactgt tcggcatcct cggcccgaac ggcgccggga
    15601 agacgacgac gatcaaggta ctgctgacca ccctgctccc caccagtggc cgcgtgtcgg
    15661 tactcggcca cgacgtgacg acccacgtca agcaggtccg tcgccgggtg ggccacgttc
    15721 tcggcggcga caagggtttc tacgaccggc tgaccgcgag gcagaatctc acctacttcg
    15781 ccgacctcta cgaagtgccc catcgtgttc agcgcacacg gatcccggag ctcctggaac
    15841 aggtcggtct gagcgagcgg tcgcgggaca gggtggaggt ctattcccga ggcatgaagc
    15901 agcggctcca catcgcacgc agcctggtcc acgacccgca ggtactcatc ctcgacgagc
    15961 cgacgaacgg catcgacccc gtcggcgcac gcgagttgcg cgagctcacc gccggcctga
    16021 cgcggcaggg gaagacagtc ctgctgacca cccattacat gcacgaggcc gaggcgatgt
    16081 gcgagcgtct cgtcgtgctg gcccgtggca ggatcatcgc atccggcacg ccgtccaccg
    16141 tcaagcgggc cgtgggcata ccccgcgtca ccgagatcga agtcgacggg ctggaaccgg
    16201 agcgcatcgc cgcgattcgc ggccttgccg gcgtgacgag cgtcgaggtg gacgcggtcg
    16261 acgcgcggca gttgatccag gtgcggaccg agccggacgc cgactgcctg caggctgtca
    16321 tccaggcgct gggcagggtc cgcatcggcc ggataacgac ccacgatccc accctcgagg
    16381 acgcgtacgt ggccctcgtg tcccgcgccc cgcgcgacgc gtcatgactc tcctccgttt
    16441 cctggccacg gcgtggatcc tcaacttccg tcagatgtcc accacgaagc tctacctgtt
    16501 cgacgccgtc atccttccgg tcatccttgc caccatcgcc caccggctgg ccggagacgt
    16561 ccgggacgcc acagccgcga cagtgacaac cctgggtgcc gccgtgctgg gcatgtgggc
    16621 ggcgacgctc agtggcacgg gcgcggcgat cgggcgcatg cgctcgttcg gcctgctcga
    16681 gccggtggtc gccgcgcccc tgccgttgtc ggcagcgctc gcctccaacg ccctggcgag
    16741 ttctgcgctc ggcatctacg cgatggccgc gacactcggc tgggccaggc tggcgctcgg
    16801 cctgcctctg cacgtcgcat cgccgacgat gctggtcgcc gccgcggtca cgtgtgtctt
    16861 ctccaccgcg gcgctcggtc tcgtcctgtc ggtgtccctg gtgctgtacc cgcgagcgca
    16921 cgcggtgagc aacatcttcg agtacccgat ctggctcctc accggcgcct gggtgccgct
    16981 gggcgtcatg ccggactggg tcgacaccgt cagttgggtg gtgggtccgg cgtggggcat
    17041 gaaatcgatc cgcgcggcgg tggccggcga cgtcaccgcc gcgctgtcgg cgctcgtcgc
    17101 ctgcgcgatc gtcaccgcac tctactggct gttcagcgtc cttctcctgc gacgtgtgga
    17161 gagacttgct cgagaaaggg ccacgttacc gctgtcatga acggactacg aatcgtcgtg
    17221 gtggggggct tcctcgccta ccagggcctc ttccagtggt tcagcagacg cctgatcctg
    17281 ccgaccctgg tgctcaggcc gatgatgcag ctggcggtgt tcaccgtcat cggcgcgtat
    17341 ctcggaagcc aacccgccga cttctacgca gtcggcaacg cggtccagac gacagcgcgg
    17401 gcgtcggtct acgcggccac catcgtgatc gccgccgaac gcatgaacgg cacgctgatc
    17461 acggtcctgg ccgcgccggc ccacccgctg ctggtattcg gcggacggct gctgccaccc
    17521 gtcctcaccg gcgtcgcttc ggcggccctg atgatgaccg tggcgatggc gacgacgggt
    17581 gtgcgcctgt cgtggtcggc gacaccgtcg ttgctgctgc tcatcctgct ggtgtccgcg
    17641 tcctgcggcg cgttcggact cgtactgggt gccatcggcc tctatctccg tgacgtgttc
    17701 tttctcccga atgtcgccgt ctacgccatg atgcttctct gcggtgtcaa cctcaccccc
    17761 gccgagacgt caggcgtgct cgccctgctc ggcgaggcgc tccctctcac ccacggcctg
    17821 cgcgcgatcc gggacgtgat cgccggccga cctgtcacga ccgcggcctg gacgaccgaa
    17881 ctgctgctgg tgttcgccta cggtgccgct gcctgcgtgt tcctggcgta cttcgcgaga
    17941 caagcccggt ccaaagcgac cttggacctg agtagctagg gatggatcat gaccactgac
    18001 atcgacaccg gggttctggt cgtcggcgcc gggcccgtgg gcgtctcgct ggcgtgccga
    18061 ctcgcccgta ggggcgtggc gaccatgctc gtcgaagctg ccgccccggc cgcgccgacg
    18121 cgcaacgtcg gcctggccaa ctggcccacc aacctggcac gaagctcggg gttcggcggg
    18181 tccctgcgcc actggcgcgg gttgtgccgg ccgttcgccg aggaggacct ccgtgagcgc
    18241 agctgggtgt ccggcagcgg ctggccggtg gcgtcggcgg acctggccgg ctttcaccgc
    18301 gacgcggcgc ggcatctcgg tgtggctgcg gaatacacga tcgcggcctg gcagggggcg
    18361 tggcagaacg acctgcccga catggccgcg ctcggtctcg tgccccgggt gtacgccctc
    18421 agtccggacg gcctggccct ggacaacctg cggcagctgg ccgtgcggga ggagtgtctc
    18481 tcctacctcg acggcggccg gctggtcgaa ctgtacggcg acaacgcttc tcgatcgatc
    18541 cactccgcgc tggtgcgccg ctcggacggt acgcgggtgc gcgtgcgcag ccgggccacg
    18601 gtactcgcca tgggcgccat cgagaccgcc aggcacctca tgcacttcgg cctgggcaac
    18661 gcctgggtcg gccgctcctt tctcgaccac ccgcacaccc tgctcggcgt gctccgcgag
    18721 gcggacaccg cccgcctgga accgctgctc gagacgggat tctctgcgca cgggccggcc
    18781 aggatgctgc tgcacctgac tccggaggcg caggaccgac acgcggtgcc ggcggcgagc
    18841 ctgaccgcgc acacgctgac cgggacgaac gccctcgcgc tcctcgcccg gacggagcag
    18901 ctcccgaacc cggacagccg tctgcacctg cgggaagccg tggacagcga cggcgtgcgg
    18961 ctggtggaca tcgcctggaa cctgcacgcc gccgacctcc gggcgctgcg ggtgctcgag
    19021 gagtcgacgg ctgcggcatt ccgcgcgcac ggactgggtc gcgtcgtcac cggttcctgc
    19081 tcttccacct cgtggcccgc cggaaccgtg ggtgcgtgcc accacctcgg cacgacgaga
    19141 atggcgacgt cccccgatca tggggccacg gacgagttcg gccgactcca cgggctggac
    19201 aacctgtgga tcgccggcgg agcggtgttt cctaccggaa ccgtggtcaa cccgacgctc
    19261 accgcggtcg cgctgggact gcggaccgca gaccggatcg cggaactcgt accggtcacc
    19321 ggtgtcagcg cccagggcgt cgacctgtgc gagcctgggt ccgggcgacc tgacggggcc
    19381 gtcgaacgat tcatcggcct gctcggcgac cgcctcgcga gccaggcccg acgcctggtg
    19441 gtggaggacg gtctggccga cgccgaactg ctggtgctgg acctcgacgg gacacttctc
    19501 cgagcgcaca ccgagcagtt gatcgcgcag gtcagccgct tcgtcgcgcg gttcggctac
    19561 gacgtcgacg cgccgacgct gcatgcgctc gcccggaacg agaacatgtt cggatttctc
    19621 cggcccgacg acgtcggggt cctcgatctg ctgttctggg accagttcga cgaatcgtcg
    19681 atgccccccg ccctgcacga cggcgcgctg gccctgctgc agttcgcccg cgcgtgcggc
    19741 ctgaccatcg cggtctgcac ggctaggcgg gcggaggcac ctgtcgtcga gcagctgctc
    19801 aggatgctcg gctgcccccc gcccagcctc gtcgtcagcg cggggccggc cggggcggcg
    19861 aagagcgaga tgctcgtcgc gttgtgcgag cgcgcggggg tgtcaacgag acgtaccgtc
    19921 acggtcgggg acaccgtgac ggacatcgtg gcgagtcgcg ccgccggcat cggccttcac
    19981 atcagcgtgg gctgcggcgt ggcgtccgct gcggcgctgg ccaaggctca gccggatgtc
    20041 ctggtggagg atctcggcga gctgctggac ctgtggctga accagcagag cggtatgagt
    20101 cgggcatgag gatcgggacg acaggccccc ggatcgaccg gatcagctcg gggcggatgt
    20161 cggtgcggtg accatccgcc tgcgcctacg ggcagggcgg tggccgtgat ggtcgccttc
    20221 ggttcccgtg ggaaccgata cggcccgcag cacgctgcgg gccgtatcgc tccctgccgt
    20281 gaccacgggc agagcacggg gctcccccag gtccggactt cgcccgcgac gggctaccgt
    20341 gcggttccgt cgcgccgaga aggcagcgtc actgctggcc ttccggggcg cgcgcgtcca
    20401 gttgtgccgc cacggccgtg gcgaccgcgt cgacggtgac ggtctgctgg tcacccgagg
    20461 ccatgcctct gacgaccacg ttgccggccg cccagtcgga cggcccgacg atgacgatcg
    20521 cacgggcgcc ggtcttgtcg gcgcggctga tctccttgcc gagtttgcgc ggctccaggg
    20581 gcaccgaggt ccgccacccg ctgccgcgca ggatacgcgc cacggaggct gcctgttcgt
    20641 agagatccgc ctggctgggg atgacgacca cgtcggcttc ggggagcggc tcgggcagga
    20701 tcccgtgcgt ctccaggaag tcgaacagcg tgacgtcgcc catgccgaag ccgaagccgg
    20761 ggatctgggc atcggagaac aggttgacca gatcgctgta gcggccaccg ccgaacagcg
    20821 cccgactgtt ggcgggatga cggtcgaaga cctcgaagac ggtcgacgtg tagtaggcga
    20881 gtccgcgaac gatgaacggg tcgaacgtca ccagttcccg tcccggtccg tcgagcacct
    20941 tcgccagctg cgagcgctgc atgacgtcgg cggggatggc ctccaacagc ttctcgcccg
    21001 cgctgagagc ctcctcaaga cggtcgaact gcgcgggtga caccccgatg cctgcggctt
    21061 cctcgagaag ctgttcgtgg ggatacttgt cccaccggtc gatcaacgcg gcgaccgtct
    21121 tcaccttctc ggccggaatg ccgaccatct cggtgagaat gccgtcgagg aggacccggt
    21181 cgcttgcccg caccacgtac atgtcacggg atgcgcccag ggcggccatc atgtcgtgga
    21241 tcagctcgaa gatctcgatc tcgacgttcg ggctggccga gccgaacgtg tcgacattga
    21301 tctgccagtg ttcccgtacc cggccccgtt gcgggcgctc gtaacggtgg cagttcacgt
    21361 ggcagtacca gcgaaccggg aattgcagct tgttcgcgtt cgcggcgatc atgcgggcga
    21421 cggaggg
//
