LOCUS       NZ_AP023438            20951 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Micromonospora sagamiensis strain JCM 3310 chromosome, complete
            genome.
ACCESSION   NZ_AP023438
VERSION     NZ_AP023438.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora sagamiensis
  ORGANISM  Micromonospora sagamiensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Micromonosporales; Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 6930736)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014680085.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:12:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,941
            CDSs (total)                      :: 5,859
            Genes (coding)                    :: 5,751
            CDSs (with protein)               :: 5,751
            Genes (RNA)                       :: 82
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 108
            CDSs (without protein)            :: 108
            Pseudo Genes (ambiguous residues) :: 0 of 108
            Pseudo Genes (frameshifted)       :: 30 of 108
            Pseudo Genes (incomplete)         :: 88 of 108
            Pseudo Genes (internal stop)      :: 5 of 108
            Pseudo Genes (multiple problems)  :: 15 of 108
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:39:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 825007
            Orig. end                         :: 845958
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023438.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017556
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20951
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20951
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20951
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10951](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10951
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    1126..1141
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.91"
                     /tool="antismash"
     gene            complement(1481..1963)
                     /gene="hisI"
                     /locus_tag="IGA62_RS03210"
                     /old_locus_tag="GCM10017556_06550"
     CDS             complement(1481..1963)
                     /EC_number="3.5.4.19"
                     /GO_function="GO:0004635 - phosphoribosyl-AMP
                     cyclohydrolase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072124.1"
                     /locus_tag="IGA62_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06550"
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="WP_145816331.1"
                     /transl_table=11
                     /translation="MPVPDAPVTGVPASPHHPAPTGPVRPSRLDPAIAARLRRGPDGLV
                     AAVVRQHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRQEYWVKGATSGHHQYVRSVA
                     LDCDGDALLVSVDQVGPACHTGRRSCFSAELPVVTGRPGEPPVGDLPVTEGAVGAP"
     gene            2191..2925
                     /locus_tag="IGA62_RS03215"
                     /old_locus_tag="GCM10017556_06560"
     CDS             2191..2925
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019868859.1"
                     /locus_tag="IGA62_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06560"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_145816329.1"
                     /transl_table=11
                     /translation="MDNAITLDGLVVDRGGRRVLEGVSCAVPRGTVTGLLGPSGSGKTT
                     LMRAVVGVQTVSSGTVTVLGRPAGTAALRRQVGYLTQAPSVYADLTVRENVRYFAAVHG
                     RGRADADRAVAEVGLTEAAGQLASALSGGQRSRVSLACVLVGQPELVVLDEPTVGQDPV
                     LRADLWARFHELAAAGTTLLVSSHVMDEAARCDRLLLIRQGRLLADDTPDGVRAAAGVT
                     DLDEAFLRLIRATEARAGREES"
     gene            2922..3677
                     /locus_tag="IGA62_RS03220"
                     /old_locus_tag="GCM10017556_06570"
     CDS             2922..3677
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014389.1"
                     /locus_tag="IGA62_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06570"
                     /product="ABC transporter permease"
                     /protein_id="WP_145816326.1"
                     /transl_table=11
                     /translation="MNPRIVAATAGRVLRQLRHDPRTIALLLVVPSLLLVLLYFMFSEQ
                     PTPPGQPSTFDRVALVMLGVFPFTIMFLLTSIAMLRERTTGTLERLLTTPLGKLDLLLG
                     YGLAFGLAAAVQATVVAVVAYGLLDLETAGSAPLVIVIAVVTALLGMALGLLCSAFART
                     EFQAVQFLPVVVFPQLLLCGLFVAREQMVGWLQAVSDVFPLSYAVEALREVGAHAEPTA
                     TMWRDLAVLAGAALLALVLAAATLRRRSG"
     gene            3756..4364
                     /locus_tag="IGA62_RS03225"
                     /old_locus_tag="GCM10017556_06580"
     CDS             3756..4364
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018826778.1"
                     /locus_tag="IGA62_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06580"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_145816324.1"
                     /transl_table=11
                     /translation="MSGRTGRRPGNPDTREAILAAARTAFAARGFDAASIRAIAGAAGV
                     DPALVHHYFGSKDKLFLAAMNAPIDPARLLPGVLDGDPERIGERLVRAFLAVWDSPAGM
                     AGVALLRSAVTTDWTARLLREFLVTQVLRRVLQHLDADPAELPLRGSLAATQMGGLVLM
                     RYVIRLEPLASTPSETLVTAIGPGVQRYLTGPLDGVFPD"
     gene            complement(4369..5112)
                     /locus_tag="IGA62_RS03230"
                     /old_locus_tag="GCM10017556_06590"
     CDS             complement(4369..5112)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014441676.1"
                     /locus_tag="IGA62_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06590"
                     /product="DUF2470 domain-containing protein"
                     /protein_id="WP_145816322.1"
                     /transl_table=11
                     /translation="MRPSSAETVRTLVAGSLPGLVHLAHRPGPYQVRHVTDPDGRVLML
                     VPVVSDLAAALRPTGDVAVVLDVLDLPPAAGAPSLGRAWVSGWAALLRGADVRDAAVDF
                     AAVEPTGDLLDVGTRFRLYRFEVAEARLDVAGEVRRVPRDEYAAADPDPLHPVEGALLA
                     DFAEHHGDQIAAYLRRQLGRLGERAGAPPRIVRVDRYGLVVSLGGPGARQRARLAFPRP
                     VADHADLARLLHPVLCRRQASPRPA"
     misc_feature    5127..5145
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 31.19"
                     /tool="antismash"
     misc_feature    complement(5132..5150)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 26.31"
                     /tool="antismash"
     gene            complement(5208..6986)
                     /locus_tag="IGA62_RS03235"
                     /old_locus_tag="GCM10017556_06600"
     CDS             complement(5208..6986)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287564.1"
                     /locus_tag="IGA62_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06600"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_145821834.1"
                     /transl_table=11
                     /translation="MGGTGQPTERAETAWRTLRRGLALSPELRVGLAGTLALALVFMVG
                     RAAVPVAVQQGIDRGLVDGIDLGTVGTVVALTAATLVVTTLCGYLMMRRLFTVSETALA
                     NVRTRAFRHVHDLSMLHQQSERRGSLVSRVTSDVDQITQFLQWGGVILMINLGQLVVTT
                     IVMFVYSWQLTLVVFAAFLPAVLVIRALQRRLGAAYGVVRQRLGALLATVAESVVGASV
                     IRAYGIAGRTARRLDEAIDDHRRAQQRAIRFSILGSSVGELAAGLALAGVVVVGVSLGA
                     DQTLSVGQITAFLFLVTLFIQPVQIATEVLNEAQNAIAGWRRVLDVLDLTPDVADPGEQ
                     GRQLPPGPLDVRFAQVGFAYPGGPPVLHDIDLEIPAKTRVAVVGETGSGKTTFAKLLTR
                     LMDPTTGTVLLSGVPLDQVRFDSLRSRVVMVPQDGFLFDATVGENVRFARPDLSDEQLV
                     AAFTELGLIDWLEGLPSGLDTPVGERGEALSVGERQLVALARAYVADPDLLVLDEATSA
                     VDPATEVRLQRTLDAVTRGRTTLAIAHRLSTAQAADEVIVVDRGRVVQRGPHDELIREP
                     ESVYGLLYASWLEQTR"
     gene            complement(7183..9069)
                     /locus_tag="IGA62_RS03240"
                     /old_locus_tag="GCM10017556_06610"
     CDS             complement(7183..9069)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020215714.1"
                     /locus_tag="IGA62_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06610"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_145816320.1"
                     /transl_table=11
                     /translation="MSSRTSTAVLIRGLRVLGRAVREQPRIFTIAVGGSLLFGAMVIGS
                     AYVIGAVVGDVVVPSITRGSVETGVLALAAAALLGISVLRVIGIFGRRLGAGYMQYRLQ
                     AAYRRRVTRRYLELPLAWHQRHATGTLLSNANSDVEAAWYPIAPLPFAVGTLVMVVGAV
                     VTLFLTDWAFALVGVAVFPALFALNVVYSRRMAPRQARAQQLRAEVSGIAHESFDGALV
                     VKTMGREAQETRRFAARAGELRDALIAVGRLRGLFDPLLETLPSIGTLAVLVVGAVRLR
                     QDAITVAELVSVAFLFTVLAVPVRAIGWVLAELPRSVAGWDRVQQVLRATGEMAYGDRV
                     LDPAGGGPATLAFTDVSFRYEPAEAHLPGAEVLGGVTFTVPAGRTVALVGPTGAGKSTI
                     TALAVRLVDPDAGTVTLDGVDLRELTAASLAGNVALVAQVPFVFDDTVRANITLDRPGI
                     SDDDVWAALRLAEADGFVAALPEGLDTRVGERGTSLSGGQRQRLTLARALAGRPRLLVL
                     DDATSAVDPRVEAAILAGLRSSATDGTGPGTSIMVVAYRRATIALADEVIYVEQGRVVA
                     RGTHAELLATVPGYVDLVTAYEQAETDREQARTYQDPAVVPVTTGLEVEMDR"
     gene            9222..9851
                     /locus_tag="IGA62_RS03245"
                     /old_locus_tag="GCM10017556_06620"
     CDS             9222..9851
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183502.1"
                     /locus_tag="IGA62_RS03245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06620"
                     /product="TIGR03085 family metal-binding protein"
                     /protein_id="WP_145816318.1"
                     /transl_table=11
                     /translation="MSRYARSERQALADLMLALGPDAPTLNEGWVARDLAAHLVVRERR
                     PDAAGGILLPPLRGYAERVRLRIAARPWAELVAQVRQPPAWSPLSNPLTDELVNTMEFF
                     IHHEDVRRAGPGWQPRDLPVGLHAALWKRVAPMARFALRRFPASLLVQAPGHGEVRCGR
                     GGEALRLVGAPGELTLFLSGRQRAARVQLDGPAATADRLRTAKLGL"
     misc_feature    9955..9969
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.27"
                     /tool="antismash"
     gene            10001..10951
                     /locus_tag="IGA62_RS03250"
                     /old_locus_tag="GCM10017556_06630"
     CDS             10001..10951
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287567.1"
                     /locus_tag="IGA62_RS03250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06630"
                     /product="terpene synthase family protein"
                     /protein_id="WP_145816316.1"
                     /sec_met_domain="T1TS (E-value: 2e-77, bitscore: 259.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSFALSTLREPPFPGRCHPAVAEVARESADWADRLGLTGSAESR
                     RRLAGAAAADLAGRACPEAPVARLRLLTDLITWLFAVDDACDEDGLGDTPTRLAPTVAG
                     LLDVLDLRGDPAPPALLGTTGPRGVALHDLCRRVRARARPAVLLAFTGQLREYLLALLW
                     EAANREHRRVPGVAEYVQMRRHTGAVHPSFTLTDLAYDGPPPDERTDPALAALETLAAD
                     LVCWCNDVFSYGKEYRLTGDGHNLVAAIAGEEQHAEQAALLAAAELFNRALAAYTERET
                     ALLRTADPATHRFVAARRGWIRATWDWSLAASRYA"
     misc_feature    complement(11035..11050)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.38"
                     /tool="antismash"
     gene            11079..12905
                     /locus_tag="IGA62_RS03255"
                     /old_locus_tag="GCM10017556_06640"
     CDS             11079..12905
                     /NRPS_PKS="Domain: AMP-binding (14-471). E-value: 8.5e-90.
                     Score: 293.2. Matches aSDomain:
                     nrpspksdomains_IGA62_RS03255_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475807.1"
                     /locus_tag="IGA62_RS03255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06640"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_145816314.1"
                     /sec_met_domain="AMP-binding (E-value: 3.4e-86, bitscore:
                     287.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALDVPYRSIPDMFLKRVAATPDRPAFAHPAPDDSGPVWLTWEQV
                     GHRAKAVAAGLHGLGIGLEDRVAILANTRLEWVVADLGVMCAGGATTTVYPTTEPEDTC
                     YIVADSGSRVLFAENPTQAAKIAGADLPALTHVVLFDGTADPGAAVPQLTLAELEERGT
                     RALAAEPGLVEGIVEELGPDHLATLIYTSGTTGRPKGVELLHGGWCWEGVAQADVGLLR
                     ADDLQYLWLPLSHSFGKTLLCGATHVGLPTYVDGRVDKLVELLSVVRPTLMCGAPRVFE
                     KVYNKSVTTARDAGGVKAKIFAWAVRVGKEKVALEQAGKPVPGGLRLRHRLAEKLVFSK
                     IQDRLGGRIRVLVSGSAPLSPEIATFFAAANLPISEGYGLTETSAGNFVNRPDGLRIGT
                     VGQAMGDLECRIDTDGEILLRGRPVMRGYHNLPEETAAAFTEDGFFRTGDIGTLDADGY
                     LKITDRKKDLFKTSGGKYVAPSHIEGMFKAICPYTSQALVIGQARNFCTMLVTLDPDAI
                     KGWAAGGPLAGRDYTAIVTSPQAKEMVEGYVAELNSKLNRWETIKKVTILPRDLTIEDG
                     EITPSLKIKRRGVENNFATEIEKMYDGALAEI"
     aSDomain        11121..12491
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS03255_AMP-binding.1"
                     /evalue="8.50E-90"
                     /label="IGA62_RS03255_AMP-binding.1"
                     /locus_tag="IGA62_RS03255"
                     /protein_end="471"
                     /protein_start="14"
                     /score="293.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LKRVAATPDRPAFAHPAPDDSGPVWLTWEQVGHRAKAVAAGLHGL
                     GIGLEDRVAILANTRLEWVVADLGVMCAGGATTTVYPTTEPEDTCYIVADSGSRVLFAE
                     NPTQAAKIAGADLPALTHVVLFDGTADPGAAVPQLTLAELEERGTRALAAEPGLVEGIV
                     EELGPDHLATLIYTSGTTGRPKGVELLHGGWCWEGVAQADVGLLRADDLQYLWLPLSHS
                     FGKTLLCGATHVGLPTYVDGRVDKLVELLSVVRPTLMCGAPRVFEKVYNKSVTTARDAG
                     GVKAKIFAWAVRVGKEKVALEQAGKPVPGGLRLRHRLAEKLVFSKIQDRLGGRIRVLVS
                     GSAPLSPEIATFFAAANLPISEGYGLTETSAGNFVNRPDGLRIGTVGQAMGDLECRIDT
                     DGEILLRGRPVMRGYHNLPEETAAAFTEDGFFRTGDIGTLDADGYLKITDRKKDLFKT"
     CDS_motif       11634..11693
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS03255_0001"
                     /evalue="2.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="IGA62_RS03255"
                     /protein_end="205"
                     /protein_start="185"
                     /score="23.3"
                     /tool="antismash"
                     /translation="ATLIYTSGTTGRPKGVELLH"
     CDS_motif       12321..12395
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS03255_0002"
                     /evalue="3.50E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="IGA62_RS03255"
                     /protein_end="439"
                     /protein_start="414"
                     /score="25.8"
                     /tool="antismash"
                     /translation="GEILLRGRPVMRGYHNLPEETAAAF"
     gene            complement(13024..14478)
                     /locus_tag="IGA62_RS03260"
                     /old_locus_tag="GCM10017556_06650"
     CDS             complement(13024..14478)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (142-462). E-value:
                     2.9e-28. Score: 91.0. Matches aSDomain:
                     nrpspksdomains_IGA62_RS03260_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014395.1"
                     /locus_tag="IGA62_RS03260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06650"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_145816312.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.7e-26, bitscore:
                     91.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQVRGGQLARLLGQWHALPGRRRSPDYAALAAAVRGLLADGRL
                     PLGVRLPAERELAEALRISRTTVTAAYRELRESGHLNSRRGAGSWTMLPGGHRVASSGL
                     WTPQDDLDMIDLGIAALAAPPELVPATRAATEDLPRYLGSAGYHPTGIIELREAIARSY
                     AERGLPTSPEQIMVTNGTQHALDLVLRLALAPAGSVLVESPTYPNALAALAARRARIAT
                     HGLALDAGWDADLLLASIRQSRPRLAYLIPDFQNPTGHLMPVDLRERVVGAAHAAGTDL
                     VVDESFVDLPLDGTPVPPPTATFDRHSRVITIGGMSKPYWGGLRIGWVRASAPQVQRLA
                     AARIGVDMSSPVLDQLVAVHLLADAATIVAARRTQLAHQRDALLAALAERLPQWRVAVP
                     RGGVTLWAELDGPVSSALARAAEEVGVRLAPGPRFGLDGTLERFLRLPFTLPAADLVDA
                     VHRIAAVRYDLDRAGRPQWREPSVIA"
     aSDomain        complement(13093..14052)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS03260_Aminotran_1_2.1"
                     /evalue="2.90E-28"
                     /label="IGA62_RS03260_Aminotran_1_2.1"
                     /locus_tag="IGA62_RS03260"
                     /protein_end="462"
                     /protein_start="142"
                     /score="91.0"
                     /tool="antismash"
                     /translation="GSAGYHPTGIIELREAIARSYAERGLPTSPEQIMVTNGTQHALDL
                     VLRLALAPAGSVLVESPTYPNALAALAARRARIATHGLALDAGWDADLLLASIRQSRPR
                     LAYLIPDFQNPTGHLMPVDLRERVVGAAHAAGTDLVVDESFVDLPLDGTPVPPPTATFD
                     RHSRVITIGGMSKPYWGGLRIGWVRASAPQVQRLAAARIGVDMSSPVLDQLVAVHLLAD
                     AATIVAARRTQLAHQRDALLAALAERLPQWRVAVPRGGVTLWAELDGPVSSALARAAEE
                     VGVRLAPGPRFGLDGTLERFLRLPFTLPAADLVDAVHRI"
     misc_feature    complement(14254..14256)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14539..15183
                     /locus_tag="IGA62_RS03265"
                     /old_locus_tag="GCM10017556_06660"
     CDS             14539..15183
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018832747.1"
                     /locus_tag="IGA62_RS03265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06660"
                     /product="YitT family protein"
                     /protein_id="WP_145816310.1"
                     /transl_table=11
                     /translation="MAPTGNLRDRLPRRLVQLFAGLALYGVSMAFMIESNLGLDPWDVF
                     HQGLARHTGLSFGTATILVGLLVLLLWLPLRQRPGLGTVSNVLVVGLVIDASLALLPDV
                     RPVAARTALLAAGILLNGLATALYLGARLGPGPRDGLMTGYVARHPGRSVRLVRTVIEV
                     AVLALGWLLGGTVGVGTVAYALAIGPLTQAFLPLVTVSGADAPVRPLAEPV"
     gene            15251..15721
                     /locus_tag="IGA62_RS03270"
                     /old_locus_tag="GCM10017556_06670"
     CDS             15251..15721
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007462954.1"
                     /locus_tag="IGA62_RS03270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06670"
                     /product="hypothetical protein"
                     /protein_id="WP_145816308.1"
                     /transl_table=11
                     /translation="MGAEGWRWSDAWIFVALVIASGAGRHRRAPSSRRPEGVRLTDVLS
                     TADHLNQAIPQRHEVETAVRRLAGAGLVSVTDGWFRITPAGEQLWRTRPAAGLSTAVDT
                     VQTALSRRHAPGQADWVLPEEEHAAAVHEYVKRSIPTPRRSPEGGGPGRDRG"
     gene            complement(15775..16581)
                     /gene="hisF"
                     /locus_tag="IGA62_RS03275"
                     /old_locus_tag="GCM10017556_06680"
     CDS             complement(15775..16581)
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019900882.1"
                     /locus_tag="IGA62_RS03275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06680"
                     /product="imidazole glycerol phosphate synthase subunit
                     HisF"
                     /protein_id="WP_145816306.1"
                     /transl_table=11
                     /translation="MTVAVRVIPCLDVDAGRVVKGVNFVDLRDAGDPVELAAAYDRAGA
                     DELTFLDVTASSDDRGTMLDVVRRTAESVFIPLTVGGGVRRVADVDVLLRAGADKVGVN
                     TAAIARPELIAEIAERFGRQVLVLSLDVRRAPAGTSDSGFEVTTHGGRRGTGLDAVEWA
                     HRVAVLGAGEILLNSMDADGTKAGFDLELIRAVRAVVDVPVIASGGAGAVAHFPPAVAA
                     GADAVLAASVFHFGELSIGDVKDALHAAGHPVRLPVAAPAGVPAEA"
     gene            complement(16790..17788)
                     /locus_tag="IGA62_RS03280"
                     /old_locus_tag="GCM10017556_06690"
     CDS             complement(16790..17788)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016628 - oxidoreductase activity, acting
                     on the CH-CH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (79-330). E-value: 1.8e-19.
                     Score: 62.0. Matches aSDomain:
                     nrpspksdomains_IGA62_RS03280_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007462967.1"
                     /locus_tag="IGA62_RS03280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06690"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_145816304.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.3e-23, bitscore:
                     80.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVNREIHLASRPDGWPTPENFRLVSTSVPTAGDGQLVVRNVVMS
                     VDPYMRGRMNDVKSYVPPFRLDAPLDGGAIGEVVQSRAEGYAPGDLVLHGLGWREYALL
                     DAGSARRVDPALAPVNAYLSVLGMTGLTAYAGLLEVAGMRAGETVFVSAAAGAVGSLVG
                     QIAKLRGAARVVGSAGSPAKVERLRALGFDVAFDYHDGPVRDQLRAAAPNGIDVYFDNV
                     GADHLEAAIAALRPHGRAAICGMIAHYNATEPPPAPRNLALVIGKQLTLRGFLVNSYGH
                     LREQFVEEASGWLREGRLHQDETVVDGIENAPAAFLGLLRGENLGKMLVRL"
     aSDomain        complement(16799..17551)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS03280_PKS_ER.1"
                     /evalue="1.80E-19"
                     /label="IGA62_RS03280_PKS_ER.1"
                     /locus_tag="IGA62_RS03280"
                     /protein_end="330"
                     /protein_start="79"
                     /score="62.0"
                     /tool="antismash"
                     /translation="QSRAEGYAPGDLVLHGLGWREYALLDAGSARRVDPALAPVNAYLS
                     VLGMTGLTAYAGLLEVAGMRAGETVFVSAAAGAVGSLVGQIAKLRGAARVVGSAGSPAK
                     VERLRALGFDVAFDYHDGPVRDQLRAAAPNGIDVYFDNVGADHLEAAIAALRPHGRAAI
                     CGMIAHYNATEPPPAPRNLALVIGKQLTLRGFLVNSYGHLREQFVEEASGWLREGRLHQ
                     DETVVDGIENAPAAFLGLLRGENLGKMLV"
     CDS_motif       complement(17312..17353)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGA62_RS03280_0001"
                     /evalue="5.70E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="IGA62_RS03280"
                     /protein_end="159"
                     /protein_start="145"
                     /score="9.5"
                     /tool="antismash"
                     /translation="GETVFVSAAAGAVG"
     gene            complement(17785..18210)
                     /locus_tag="IGA62_RS03285"
                     /old_locus_tag="GCM10017556_06700"
     CDS             complement(17785..18210)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287575.1"
                     /locus_tag="IGA62_RS03285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06700"
                     /product="organic hydroperoxide resistance protein"
                     /protein_id="WP_145821833.1"
                     /transl_table=11
                     /translation="MQVLYTAAAHATGDGRDGHVRTSDGTVDLDLAVPKEMGGAGGAAN
                     PEQLFAAGYAACFHSALRLVARRAKADVSGSVVDAEVGIGPNGDGGFTLTVGLVVDLPS
                     VPRAVAEDLVARAHQVCPYSNATRGNIDTTLTVRDAA"
     gene            complement(18216..18662)
                     /locus_tag="IGA62_RS03290"
                     /old_locus_tag="GCM10017556_06710"
     CDS             complement(18216..18662)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018734368.1"
                     /locus_tag="IGA62_RS03290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06710"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_145816302.1"
                     /transl_table=11
                     /translation="MDDDLVLRRQVCFALYTASRAVTDVYRPILDELGLTYPQYLVLLV
                     LWERGEAAPTVSELGADLRLDSGTLSPLLKRLEGAGLLVRRRAARDERRVEIELTAAGR
                     ALRDRACDVPHRVAASTGLTLDELVALRDTLTRVTETIHRHKGK"
     misc_feature    complement(18684..18697)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.03"
                     /tool="antismash"
     gene            complement(18751..19476)
                     /gene="priA"
                     /locus_tag="IGA62_RS03295"
                     /old_locus_tag="GCM10017556_06720"
     CDS             complement(18751..19476)
                     /EC_number="5.3.1.16"
                     /EC_number="5.3.1.24"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003949 - 1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="priA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018813684.1"
                     /locus_tag="IGA62_RS03295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06720"
                     /product="bifunctional 1-(5-phosphoribosyl)-5-((5-
                     phosphoribosylamino)methylideneamino)imidazole-4-
                     carboxamide isomerase/phosphoribosylanthranilate isomerase
                     PriA"
                     /protein_id="WP_145816300.1"
                     /transl_table=11
                     /translation="MSLTLLPAVDVADGQAVRLVQGAAGSETAYGDPLEAALAWQNDGA
                     EWIHLVDLDAAFGRGSNAPLLAEVVRRLDVKVELSGGIRDDASLRAALATGAARVNIGT
                     AALEDPQWCDRICGEYGDRVAIGLDVRGRTLAARGWTRDGGDLFEVLERLDKAGASRYV
                     VTDITKDGTMRGPNLDLLREVCARTDAPVIASGGVSTLDDLRALATLEPVGVEGVIAGK
                     ALYAGAFTVAEALRVLADA"
     gene            complement(19492..19818)
                     /locus_tag="IGA62_RS03300"
                     /old_locus_tag="GCM10017556_06730"
     CDS             complement(19492..19818)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014402.1"
                     /locus_tag="IGA62_RS03300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06730"
                     /product="hypothetical protein"
                     /protein_id="WP_145816298.1"
                     /transl_table=11
                     /translation="MSKERARLRAAREAERERDRAVRARRVARRERRRALLRRLRPGWR
                     RRRTGRLLARRSRAERAGIVVLTLAVLGSIWTLVPDPALRVLLMVLLLLVLPAIVVIAL
                     DRRT"
     gene            complement(19851..20471)
                     /gene="hisH"
                     /locus_tag="IGA62_RS03305"
                     /old_locus_tag="GCM10017556_06740"
     CDS             complement(19851..20471)
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475799.1"
                     /locus_tag="IGA62_RS03305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06740"
                     /product="imidazole glycerol phosphate synthase subunit
                     HisH"
                     /protein_id="WP_145816295.1"
                     /transl_table=11
                     /translation="MSRVVVLDYGSGNLRSAERALQRAGADVTVTADLTAAAAADGLVV
                     PGVGAFAACMAGIEALGAGPVIADRVAAGRPVLGICVGMQVLFSHGEEHGVVTRGLGLL
                     PGGVTRLAATRLPHMGWNTLRPPAGSTLFAGLPEGGRFYFVHSYAVADVAALTAAGAVV
                     TTARHGDDFVAAVERGALSAAQFHPEKSADTGALLLRNWLGTL"
     gene            complement(20468..20641)
                     /locus_tag="IGA62_RS03310"
                     /old_locus_tag="GCM10017556_06750"
     CDS             complement(20468..20641)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072142.1"
                     /locus_tag="IGA62_RS03310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_06750"
                     /product="hypothetical protein"
                     /protein_id="WP_186499759.1"
                     /transl_table=11
                     /translation="MDTVLPSLLLILAGLLAGGVVSLHRQGAARGVVVVTALLALLAGV
                     GGVLWLIPLVTS"
ORIGIN
        1 tcccggtcct cggcggcggg atcagaatcg gccaccaccc ccgcgccggc ctggacgtac
       61 gcccagccgt cccggatcag ggcggtccgg atcgcgatcg ccatgtccag gtccccgccg
      121 aagccgaagt aaccgaccgt gccgccgtag aggccccggc ggaccggctc caactcctcg
      181 atgatctcca tcgcccggac cttcggcgca ccggagaggg tgccggcggg gaaggtcgcg
      241 gcgagggcgt cgaacgcggt ggcgtccgga cggagggtgc cgaccacggt cgagacgatg
      301 tgcatgacgt ggctgtaccg ctcgatggtg gcgaactcgg gcacctcgac cgagcccggc
      361 cggcacaccc ggcccaggtc gttgcggccc aggtcgacca gcatgacgtg ctcggcccgc
      421 tccttcgggt cggccagcag ctcggtggcg agccgggcgt cgtgctccgg gtcgacgccc
      481 cggggccggg tgccggcgat cgggtgcagc agcgcccggc gctgcccgtc gtcgctgccg
      541 gtgaccttca ggtgcgcctc cggcgaggaa ccgacgatgt cgaagccgtc gaagcggagc
      601 aggtacatgt acgggctggg gttggtggtg cgcagcaccc ggtagacgtc cagcgggtcg
      661 gcgtgggtgc gccgctcgaa gcgctgcgcc agcacgatct ggaagcactc cccggcccgg
      721 atggcctcct tggccgcctc gaccgccttc gggtagctcc cctcggccgt ccggcaggtc
      781 accgcgccga ccggcggccg gtcgaccgtg gagatcatcg gtgggttcgg ccgggagagc
      841 gccgaggtca tcgcgtcgag gcgaccgatc gcgtggtggt aggcggcggt cacctcggcc
      901 gcccggtccg gctcgtccgg cgggggcagg accgcgttgg cgatcaggat cgccgagccc
      961 tcgtagtggt ccaggacgac caggtcggtg gcgagcatca tgcccagctc gggcacaccg
     1021 aggtcgtcct cgctgagcgt gggcagccgt tccaggcgac ggatcaggtc gtacccgagg
     1081 taaccgacca tgccgcccgt cagcgggggc atgccgctgg tcgggtcgaa cgccggtccg
     1141 gccagcgcgg tcaccgtgtc gcgcagcacc cgggccgggt cgcccccggt gggcaggccg
     1201 gcggggggct gcccgagcca ggtggcctgg ccgtgccgct cgaccagggt ggcgctgctg
     1261 cgcacgccga tgaagctgta gcgggaccag gccagcccgg ccgacccgac gccctgctcg
     1321 gcggactcca gcaggaaggt gcccgggcca ccggcgagct tgcggtagac cccgaccggg
     1381 gtctcgccgt cggccagcag ccgccggatg accgggacga cccgccagcg ggccgccagg
     1441 tcggtgaagg tggccaggtc ggggctcacc acgccgtcgg tcatggcgca cccaccgcgc
     1501 cctcggtgac cggcaggtcc ccgaccggcg gctcaccggg gcggccggtc acgaccggca
     1561 gctccgcgga gaagcagctg cgccggccgg tgtggcaggc cgggccgacc tggtcgacgc
     1621 tgacgagcag cgcgtcgccg tcgcagtcca gggccaccga gcggacgtac tggtggtggc
     1681 cggaggtggc gcccttgacc cagtactcct ggcgactgcg cgaccagtag gtggcccgac
     1741 cggtggtcaa cgtgcggtgc aacgcctcgt cgtccatcca ggcgaccatc agcacctcac
     1801 cggagtcgtg ctgacggacc acagcggcga ccaggccgtc gggaccccgg cggagccggg
     1861 cggcgatggc cgggtcgagc cgggacgggc ggaccggccc ggtgggggcg gggtggtgcg
     1921 ggctggcggg gacgccggtc accggcgcgt caggtacggg cacagtcacc cattgtcccg
     1981 cacgcggcgc ggacgccccc agcccgtccc ggttccaggg accagcccgt cgaggtcccg
     2041 gggacgccgc ggggcgacac ggcgggccgg cgaccggggg acggctgatc ggaaccggtc
     2101 ggtggcggcg tggcaggagg ggtccgttgt gtatggccga gaagtcatct accgttgagt
     2161 tcaacgggtg atgaattgag gggaggcggg atggacaacg cgatcaccct ggacggcctg
     2221 gtggtcgacc ggggcgggcg ccgggtcctg gagggcgtga gctgcgccgt accacgcggc
     2281 acggtgaccg ggctgctcgg cccgagcggc agcggcaaga ccacgctgat gcgcgcggtg
     2341 gtcggggtgc agacggtcag ctccggcacg gtgaccgtgc tcggccgacc ggccgggacg
     2401 gcggccctgc ggcggcaggt cgggtacctc acccaggcac cgagcgtcta cgccgacctg
     2461 acggtccggg agaacgtccg gtacttcgcc gcggtgcacg ggcgcggccg ggccgacgcc
     2521 gaccgcgcgg tggccgaggt cgggctcacc gaggcggccg ggcaactggc cagcgcgctc
     2581 tccggcgggc agcgcagtcg agtctcgctg gcctgcgtcc tggtcggcca gccggagctg
     2641 gtggtgctcg acgagccgac cgtcgggcag gacccggtgc tccgggccga cctctgggcc
     2701 cggttccacg agctggccgc cgccggcacc accctgctgg tctccagtca cgtgatggac
     2761 gaagccgccc gctgtgaccg gctgctgctg atccggcagg gccggctgct cgccgacgac
     2821 acccccgacg gggtacgcgc cgcggccggc gtgacggacc tggacgaggc cttcctgcgc
     2881 ctgatccggg cgaccgaggc gcgcgccgga cgggaggagt cgtgaacccg cgcatcgtgg
     2941 cggccaccgc cgggcgggtg ctgcgtcagc tccgccacga cccccggacg atcgccctgc
     3001 tgctcgtggt gccgagcctg ctgctcgtgc tgctctactt catgttctcc gagcagccca
     3061 ccccacccgg gcaaccctcc accttcgacc gggtcgccct ggtcatgctg ggcgtcttcc
     3121 ccttcaccat catgttcctg ctgaccagca tcgcgatgct gcgcgagcgc accacgggga
     3181 cgctggaacg gctgctcacc accccgctgg gcaagctcga cctgctcctc ggctacgggc
     3241 tggcgttcgg gttggccgcc gcggtgcagg cgacggtggt cgccgtggtg gcgtacgggc
     3301 tgctcgacct ggagaccgcg ggcagcgccc cgctggtgat cgtgatcgcc gtggtgaccg
     3361 ccctgctcgg catggcgctg gggctgctgt gcagcgcctt cgcccgtacc gagttccagg
     3421 ccgtacagtt ccttccggtc gtggtcttcc cccaactcct gctctgcggg ctcttcgtcg
     3481 cgcgggagca gatggtgggc tggctccagg cggtcagcga cgtgttcccc ctgtcgtacg
     3541 cggtcgaggc gttgcgggag gtcggcgcgc acgccgagcc caccgccacg atgtggcggg
     3601 acctcgcggt gctggccggg gcggcgctgc tggccctggt gctcgccgcg gccacgctgc
     3661 gccggcgcag cggttgacga ggtccggaca cggtccgccc gccggcgacg gaccccacac
     3721 cggccggcgg gcggggtgac gagcgagagg cggcgatgag cggacggacc ggacgacgac
     3781 cgggcaaccc ggacacccgg gaggcgatcc tcgcggcggc ccgcacggcg ttcgccgccc
     3841 ggggtttcga cgcggcgtcg atccgggcga tcgccggcgc ggccggagtg gacccggccc
     3901 tggtccacca ctacttcggt agcaaggaca agctcttcct ggccgcgatg aacgccccga
     3961 tcgaccccgc gcggttgctg cccggcgtgc tcgacggcga tccggaacgg atcggcgaac
     4021 ggttggtccg ggccttcctc gcggtctggg actcaccggc cggcatggcc ggggtcgcgc
     4081 tgttgcgttc ggcggtgacc accgactgga ccgcccggct gctacgggag ttcctggtca
     4141 cccaggtgct gcgccgggtg ctccagcacc tcgacgccga cccggccgaa ctgccgctgc
     4201 gcggctccct ggccgccacc cagatgggtg ggctggtgct gatgcggtac gtcatccggc
     4261 tggaaccgct ggcctccacg ccgtcggaga ccctggtcac cgcgatcggt cccggcgtcc
     4321 agcgctacct gaccgggcca ctggacgggg tcttccccga ctgacccgtc aggccggacg
     4381 gggcgacgcc tgacgtcggc agagcaccgg gtgcagcagc cgggccaggt cggcgtggtc
     4441 ggcgaccggc cgggggaacg ccagtcgggc ccgctgccgg gcgccgggcc cgccgaggga
     4501 caccaccagg ccgtaccggt cgacgcggac gatccggggc ggcgcgccgg cccgctcgcc
     4561 gagccggccg agctgccgtc gcaggtaggc ggcgatctgg tcgccgtggt gctcggcgaa
     4621 gtcggccagg agcgcgccct ccaccgggtg cagggggtcc gggtcggcgg cggcgtactc
     4681 gtcgcgcggg acgcgtcgca cctccccggc gacgtccagg cgggcctcgg ccacctcgaa
     4741 ccggtacagc cggaaccggg tgccgacgtc gagcaggtca ccggtcggct ccacggcggc
     4801 gaagtccact gcggcgtccc ggacgtccgc cccgcgaagc agcgccgccc agccggagac
     4861 ccaggcccgg cccagcgacg gcgcgcccgc cgccgggggc aggtccagca cgtcgagcac
     4921 cacggcgacg tcgccggtgg ggcgcagcgc ggcggccagg tcgctgacca ccggcacgag
     4981 catcagcacc cgaccgtcgg ggtcggtgac gtgccggacc tggtacggcc ccggacggtg
     5041 cgccaggtgc accagcccgg ggaggctgcc ggcgaccagg gtccggaccg tctcggcgct
     5101 gctcggtcgc atgatcgccc ctttccgtag gttaggctaa cctaacctgg aaggttagag
     5161 cacccggaca cgggcgtcca gccgatccgc caccgaccgc cgccgggtca ccgcgtctgc
     5221 tccagccagg aggcgtagag cagcccgtac accgactccg gttcccggat cagctcgtcg
     5281 tgcgggccgc gctgcaccac ccggccccgg tccaccacga tcacctcgtc ggccgcctgc
     5341 gccgtggaga gccggtgggc gatggccagc gtggtccggc cccgggtcac cgcgtccagg
     5401 gtccgctgga gccgcacctc ggtggcgggg tccaccgcgc tggtcgcctc gtccagcacc
     5461 agcaggtccg ggtcggcgac gtacgcccgg gcgagcgcga ccagctgccg ctcccccacg
     5521 ctgagcgcct cgccccgctc cccgaccggg gtgtccagcc cggacggcag cccctccaac
     5581 cagtcgatga gccccagctc ggtgaaggcc gcgacgagct gctcgtcgct caggtccggc
     5641 cgggcgaagc ggacgttctc ccccaccgtc gcgtcgaaga ggaagccgtc ctgcggcacc
     5701 atcaccaccc gggagcgcag cgagtcgaag cgcacctggt ccagcggcac gccggagagc
     5761 agcaccgtgc ccgtggtcgg gtccatcagc cgggtgagca gcttggcgaa ggtggtcttg
     5821 ccactgccgg tctcgccgac caccgccacc cgggtcttcg ccgggatctc caggtcgatg
     5881 tcgtgcagca ccggcggccc acccgggtac gcgaagccca cctgcgcgaa ccggacgtcc
     5941 agcgggcccg gtggcagctg gcgcccctgc tcccccgggt cggccacgtc cggggtgagg
     6001 tccagcacgt ccagcacccg ccgccagccg gcgatcgcgt tctgcgcctc gttgagcacc
     6061 tcggtggcga tctgcaccgg ctggatgaag agggtcacca ggaacaggaa cgcggtgatc
     6121 tgaccgaccg agagcgtctg gtccgcgccg aggctcaccc cgaccacgac caccccggcc
     6181 agggcgagac cggccgccag ttccccgacc gagctgccca ggatgctgaa ccggatggcc
     6241 cgttgctggg cccgccggtg gtcgtcgatc gcctcgtcca gccgccgggc ggtccggccg
     6301 gcgatcccgt acgcccggat gaccgacgca ccgaccacgc tctccgcgac cgtggcgagc
     6361 agcgcgccca gccgctgccg gaccaccccg tacgcggcgc cgaggcggcg ctggagggcc
     6421 cggatcacca ggacggccgg caggaaggcg gcgaagacca ccagggtcag ctgccaggag
     6481 tagacgaaca tgacgatcgt ggtgaccacc agctgaccga ggttgatcat caggatcacc
     6541 ccgccccact ggaggaactg ggtgatctgg tcgacgtcgc tggtcacccg ggagaccagc
     6601 gaaccacgcc gctcggactg ctggtgcagc atcgacaggt cgtgcacgtg ccggaacgcc
     6661 cgggtccgga cgttggccaa cgccgtctcg ctgaccgtga acagccgacg catcatcagg
     6721 tagccgcaga gcgtcgtcac caccagcgtc gcggcggtca gcgcgaccac cgtcccgacg
     6781 gtgcccaggt cgatcccgtc gaccaggccc cggtcgatgc cctgctgtac ggccaccggc
     6841 acggcggccc gaccgaccat gaagaccagc gccagggcca gcgtgccggc caggccgacc
     6901 cgcagctccg gggagagggc caggccgcgg cgcaacgtgc gccaggccgt ctcggcccgc
     6961 tccgtcggct ggcccgtccc gcccaccggc tccaccttct cctccaccac gaccgcgctc
     7021 accgggtcag cctctcgttc gcgactgcgg ggctcgcaag ctcactccgc acgctcaccg
     7081 ggccttcact gttcgcgact gcggggctcg caagctcact cctcacgctc accgggcctt
     7141 cactgttcgc gactgcgggg ctcgcaagct cactcctcac gctcaccggt ccatctccac
     7201 ttcgaggccg gtggtcaccg ggaccaccgc cgggtcctgg taggtacggg cctgctcgcg
     7261 gtcggtctcc gcctgctcgt acgcggtgac caggtccaca tagccgggca cggtggcgag
     7321 cagctcggcg tgcgtgcccc gggccaccac ccggccctgc tcgacgtaga tgacctcgtc
     7381 ggccagggcg atggtggccc gccggtacgc caccaccatg atcgaggtgc ccggacccgt
     7441 tccgtcggtc gccgacgagc gcagcccggc caggatcgcc gcctcgaccc gggggtcgac
     7501 cgcgctcgtc gcgtcgtcga gcaccagcag ccggggccgg ccggcgagcg cgcgggccag
     7561 ggtgaggcgc tgccgctgac cgccggagag cgaggtgccc cgctcgccga cccgggtgtc
     7621 cagcccttcg ggcagggccg cgacgaaccc gtccgcctcg gccagccgca gtgccgccca
     7681 gacgtcgtcg tcgctgatcc ccggccggtc cagggtgatg ttggcgcgca ccgtgtcgtc
     7741 gaagacgaac ggcacctggg cgaccagcgc gacgttgccg gccagcgacg cggcggtcag
     7801 ctcccgcagg tcgaccccgt ccagggtgac ggtgcccgcg tccgggtcga ccaggcgtac
     7861 cgccagggcg gtgatggtgg acttgccggc cccggtcggg ccgaccaggg cgacggtgcg
     7921 cccggcgggc acggtgaagg tgaccccgcc gagcacctcg gcgccgggca ggtgcgcctc
     7981 ggccggctcg taccggaagg agacgtcggt gaaggcgagc gtggccggcc cgccgccggc
     8041 cgggtcgagg acccggtccc cgtaggccat ctcgccggtg gcgcggagca cctgctgcac
     8101 ccggtcccac ccggccacgc tgcgcggcaa ctcggcgagg acccagccga tggcccgcac
     8161 cggtacggcc agcacggtga acaggaacgc gacgctgacc agctcggcga cggtgatggc
     8221 gtcctgacgc aaccggaccg ccccgaccac cagcaccgcc agggtgccga tgctgggcag
     8281 ggtctccagc agcgggtcga acagaccgcg cagccggccg acggcgatca gcgcgtcgcg
     8341 cagctcaccc gcgcgggcgg cgaaccggcg ggtctcctgc gcctcccggc ccatcgtctt
     8401 gaccaccagc gcgccgtcga agctctcgtg ggcgatgccg ctgacctcgg cgcgcaactg
     8461 ctgggcgcgg gcctgccggg gggccatccg ccgggagtag accacgttga gcgcgaacag
     8521 ggcggggaag acggccaccc cgaccagggc gaacgcccag tcggtgagga agagcgtgac
     8581 gaccgccccg accaccatca ccagcgtccc gaccgcgaag ggcagcggcg cgatcgggta
     8641 ccaggcggcc tccacgtcgg agttggcgtt ggagagcagg gtgccggtgg cgtgccgctg
     8701 gtgccaggcc agcggcagct ccagatagcg tcgggtcacc cggcggcggt aggccgcctg
     8761 gaggcggtac tgcatgtagc cggcgccgag acgccgcccg aagatgccga tcacccgcag
     8821 cacactgatc ccgagaaggg cggcggcggc cagcgccagc acgccggtct ccaccgagcc
     8881 ccgggtgatg gagggcacca ccacgtcgcc caccaccgcg ccgatcacgt acgcgctgcc
     8941 gatcaccatc gcgccgaaga gcaagctgcc gccgaccgcg atcgtgaaga tccgtggttg
     9001 ttcccggacg gcccgcccga ggacccggag gccccggatg agcacggccg tactcgtcct
     9061 gctcgacacg ctctacttcc cccgccgtaa gccgcaatta tctccctcat ccttaccggt
     9121 cggcgtcccg cacgccgacc cgggttcgga attgtccggt gtggcaagag tgcgccgcgc
     9181 cacgtcgggt ggtccggcgg ggcgcggcct accatcgggg aatgtcgcgg tacgcccgat
     9241 cggagcgcca ggcgctcgcc gacctcatgc tggccctcgg ccccgacgcg ccgaccctga
     9301 acgagggctg ggtggcccgg gacctcgccg cccacctggt ggtccgcgag cgccggccgg
     9361 acgcggcggg cgggatcctg ctgccaccgc tgcgcgggta cgccgagcgg gtgcggctgc
     9421 ggatcgcggc acgcccctgg gccgaactgg tggcgcaggt gcgccagccg ccggcgtgga
     9481 gcccgctgag caacccgctg accgacgagt tggtcaacac catggagttc ttcatccacc
     9541 acgaggacgt ccggcgggcc ggccccggct ggcagccgcg cgacctgccg gtcgggctgc
     9601 acgccgcgct gtggaagcgg gtcgccccga tggcccggtt cgcgctgcgc cggttcccgg
     9661 cgagcctgct cgtccaggcc ccggggcacg gggaggtgcg ctgcgggcgc ggcggcgagg
     9721 cgctccggct ggtcggcgcc cccggtgaac tgaccctctt cctctccgga cgccagcgcg
     9781 cggcccgggt gcaactggac gggccggcgg cgaccgccga ccggctgcgt accgccaagc
     9841 tgggcctctg accgaccccg cggccggcca ccgggccgcc gggcaggggc gcgaccgtcc
     9901 cggaccgggg cgggggcgaa cggaaagaac aagtccgata tcttgccccc gcacggattt
     9961 gtcggtccgc cccgcccggg acggtgtggc agggggtggc atgcggagtt tcgcgctttc
    10021 tacgctacgg gaaccgccgt tcccgggccg gtgtcacccg gcggtcgccg aggtcgcccg
    10081 ggagagcgcc gactgggccg accggctggg cctgaccggg tccgccgaga gccgacgacg
    10141 gctcgccggg gccgccgccg ccgacctggc cgggcgggcc tgcccggagg caccggtggc
    10201 ccggctccgc ctgctgaccg atctgatcac ctggctcttc gcggtggacg acgcctgcga
    10261 cgaggacggg ctgggcgaca caccgacccg gttggccccc accgtggccg gcctgctcga
    10321 cgtcctcgac ctgcgcggtg acccggcgcc cccagcgctg ctcggcacca ccggcccgcg
    10381 cggggtcgcg ctgcacgacc tgtgccgacg ggtccgcgcg cgcgcccgtc cggcggtgct
    10441 gctcgccttc accgggcagc tgcgggagta cctcctggcg ctgctgtggg aggcggccaa
    10501 ccgggagcac cggcgggtgc ccggcgtcgc cgagtacgtg cagatgcgcc ggcacaccgg
    10561 cgcggtccac ccgagcttca ccctcaccga cctggcgtac gacggaccgc cgccggacga
    10621 gcggaccgac ccggcgctgg ccgccctgga gaccctcgcc gcggacctgg tctgctggtg
    10681 caacgacgtc ttctcctacg gcaaggagta ccggttgacc ggcgacgggc acaacctggt
    10741 cgccgccatc gccggggagg agcagcacgc cgagcaggcc gccctgctgg ccgcggcgga
    10801 gctgttcaac cgggcgctgg cggcgtacac cgagcgggag acggcgctgc tgcgcacggc
    10861 cgacccggcc acccaccggt tcgtggcggc ccgccggggt tggatccggg ccacctggga
    10921 ctggtcactc gccgcctccc ggtacgcctg acgacccggg acacggggcc ccggaggacc
    10981 ggggctagcc gatgaccggg tgtacgcaat acccttcggt aaccgcagac ccagcgtgac
    11041 cacgatcacg tcaccacccc ctgaaggcgg ctacagcgat ggctctcgat gtaccgtacc
    11101 gttcgatccc ggacatgttc ctcaagcgcg tggcggccac cccggaccgc cccgccttcg
    11161 cccaccccgc ccccgacgac tcgggaccgg tctggctgac ctgggaacag gtggggcacc
    11221 gggccaaggc ggtcgccgcc ggcctacacg gtctgggtat cggactcgag gaccgggtgg
    11281 ccatcctggc caacacccgg ctggagtggg tcgtcgccga cctcggcgtc atgtgcgcgg
    11341 gcggggcgac caccacggtc tacccgacca ccgagccgga ggacacctgc tacatcgtcg
    11401 ccgactccgg ctcgcgggtg ctcttcgccg agaaccccac ccaggctgcc aagatcgccg
    11461 gggccgacct gcccgcactg acccacgtgg tcctcttcga cggcaccgcc gaccccggcg
    11521 cggccgtccc ccagctcacg ctcgccgaac tggaggagcg gggcacgcgg gcgctcgccg
    11581 ccgaaccggg cctggtcgag gggatcgtcg aagaactcgg gccggaccac ctggccacgt
    11641 tgatctacac ctccggcacc accggtcgcc ccaagggcgt cgagctgctg cacggcggct
    11701 ggtgctggga gggggtcgcg caggccgacg tcgggctgct gcgcgccgac gacctccagt
    11761 acctctggct cccgctgtcc cactcgttcg gcaagaccct gctctgcggg gcgacccacg
    11821 tcggcctgcc gacctacgtc gacggccggg tggacaagct ggtcgaactg ctctccgtgg
    11881 tccgtccgac gctgatgtgc ggcgcgcccc gggtgttcga gaaggtctac aacaagtcgg
    11941 tcaccaccgc gcgggacgcc ggcggcgtga aggcgaagat cttcgcctgg gcggtccggg
    12001 tcggcaagga gaaggtcgcc ctggagcagg ccggcaagcc ggtcccgggc gggctccggc
    12061 tgcgccaccg gctggccgag aagctggtgt tcagcaagat ccaggaccgg ctcggcggcc
    12121 ggatccgcgt gctggtctcc gggtccgctc cgctgagccc ggagatcgcc accttcttcg
    12181 ccgcggccaa cctgccgatc tccgaggggt acggcctcac cgagaccagc gccggcaact
    12241 tcgtcaaccg gccggacggg ctgcggatcg gcaccgtcgg gcaggccatg ggcgatctgg
    12301 agtgccgcat cgacaccgac ggggagatcc tgctccgggg ccgtccggtg atgcgcggct
    12361 accacaacct gcccgaggag accgccgccg ccttcaccga ggacgggttc ttccgtaccg
    12421 gggacatcgg cacgctggac gccgacggct acctgaagat caccgaccgg aagaaggacc
    12481 tgttcaagac gtccggcggc aagtacgtcg cgccgtcgca catcgagggc atgttcaagg
    12541 cgatctgccc gtacacctcg caggcgctcg tgatcggcca ggcccgcaac ttctgcacga
    12601 tgctggtcac cctcgacccg gacgcgatca agggctgggc ggcgggcggg ccgctggcgg
    12661 gtcgcgacta caccgcgatc gtcacctcgc cgcaggcgaa ggagatggtc gaggggtacg
    12721 tcgcggagct gaacagcaag ctcaaccgct gggagaccat caagaaggtc accatcctgc
    12781 cgcgcgacct gaccatcgag gacggcgaga tcaccccgtc gctcaagatc aagcggcgcg
    12841 gggtggagaa caacttcgcc accgagatcg agaagatgta cgacggcgcg ctcgccgaga
    12901 tctgacccac cacccggccc cgggcggacc ctctcgtcgc gagggaaccc gcccggggcc
    12961 ggtccgtgtc ccggccggcc ggccgagggg tgcgtgcgcc ggacggccac ccgggggcgg
    13021 cgctcaggcg atgacggagg gttcgcgcca ctgcggacgg ccggcccggt ccaggtcgta
    13081 ccggaccgcg gcgatccggt gcacggcgtc gaccagatcg gcggcgggca gggtgaacgg
    13141 cagccgcagg aagcgctcca gcgtgccgtc cagcccgaac cgggggccgg gtgccaggcg
    13201 tacgccgacc tcctcggcgg cccgggccag ggcgctggac accggcccgt ccagttccgc
    13261 ccagagggtc accccgccgc gcggcacggc gacccgccac tgcggcaacc gctcggccaa
    13321 cgcggccagc agcgcgtccc gttggtgggc gagctgcgtc cggcgggcgg ccacgatcgt
    13381 cgccgcgtcg gcgagcaggt ggaccgcgac gagctggtcc agcaccgggc tggacatgtc
    13441 gaccccgatc cgggcggcgg ccagccgctg cacctgcggg gcggaggccc gcacccagcc
    13501 gatgcgcagt ccaccccagt acggtttgct catcccgccg atcgtgatca cccgcgagtg
    13561 ccggtcgaag gtggcagtcg gcgggggcac cggcgtgccg tccagcggca ggtcgacgaa
    13621 ggactcgtcg accaccaggt cggtgccggc cgcgtgggcc gccccgacca cccgctcgcg
    13681 cagatcgacc ggcatgaggt ggccggtcgg gttctggaag tcgggaatca ggtaggccag
    13741 ccgcggtcgg gactggcgga tgctggccag caacaggtcc gcgtcccagc cggcgtcgag
    13801 cgcgagcccg tgggtggcga tccgggcccg ccgcgcggcg agggcggcca gcgcgttggg
    13861 ataggtcggc gactccacga gcacgctgcc ggccggggcg agcgccaacc gcagcaccag
    13921 gtccagggcg tgctgggtgc cgttggtgac catgatctgc tcggggctgg tgggcaggcc
    13981 gcgctcggcg tacgaccggg cgatcgcctc ccgcagctcg atgatcccgg tcgggtggta
    14041 gccggcgctg cccaggtagc ggggcaggtc ctcggtggcg gcccgggtgg ccgggaccag
    14101 ttccggcggg gcggccagcg ccgcgatgcc cagatcgatc atgtccaggt cgtcctgggg
    14161 cgtccacagg ccggagctgg cgacccggtg accgccggga agcatggtcc agctccccgc
    14221 cccgcgccga ctgttcaggt gcccgctctc gcgtaactcc cggtaggcgg cggtgaccgt
    14281 ggtccggctg atccgcagcg cctcggcgag ttcccgctcg gccggcaggc gtacccccag
    14341 cggcaggcgg ccgtcggcga gcaggccccg gacggcggcg gcgagagcgg cgtagtccgg
    14401 ggaccggcgg cggcccggca gcgcatgcca ctgaccgagc aggcgggcca gttgtccccc
    14461 gcgaacctgg ctggtcatgg ccactccctc ccgattggct ctctcgaacc gccgcgattg
    14521 gcccttaggt tggcatgcat ggccccgact ggcaacctcc gtgaccggct gccccgacgc
    14581 ctggtccagc tcttcgccgg actggcgctc tacggcgtca gcatggcttt catgatcgag
    14641 tcgaacctcg ggctggaccc gtgggacgtc ttccaccagg ggctggcccg gcacaccggg
    14701 ctctccttcg gcaccgccac catcctggtc ggattgctgg tgctgctgct ctggttgccg
    14761 ctgcggcaac gtcccggcct gggcacggtg agcaacgtcc tggtcgtcgg tctggtgatc
    14821 gacgccagcc tcgcgctgct gcccgacgtc cgcccggtcg ccgcccggac cgcgctgctc
    14881 gccgccggca tcctgctcaa cggcctggcc accgccctct acctcggcgc ccgactcggt
    14941 ccggggccgc gcgacgggct gatgaccggg tacgtggccc gtcacccggg ccggtcggtc
    15001 cgcctggtcc gaaccgtcat cgaggtggcc gtactcgcgc tgggctggct gctgggcggc
    15061 acggtgggcg tcgggacggt cgcctacgcg ctggccatcg gcccgctgac ccaggcgttc
    15121 ctccccctgg tcaccgtctc cggcgccgac gcgccggtac gaccactggc cgaaccggtc
    15181 tgagctgggc gtcccgcgag cgccgaaccg gatgttttac tccgggccac tcagccggca
    15241 tcatttcccc atgggggctg agggatggcg ttggtcggac gcctggatct tcgtggcact
    15301 ggtgatcgcc agcggagccg gacggcaccg ccgggccccg tcgagccggc ggccggaggg
    15361 ggtccgcctc accgacgtgc tctccaccgc cgatcacctc aaccaggcga ttccgcagcg
    15421 gcacgaggtg gagacggcgg tgcgtcgcct ggccggcgcc ggtctggtca gcgtcaccga
    15481 cggctggttc cggatcacac cggccggtga gcagctctgg cggacccggc cggccgccgg
    15541 gctctccacc gccgtcgaca cggtgcagac cgcgctgagc cggcgacacg caccgggaca
    15601 ggccgactgg gtgctgccgg aggaggagca cgccgccgcc gtccacgagt acgtcaagcg
    15661 gtcgatcccg accccacgcc gctcaccgga gggcggcggt ccgggccgcg accggggctg
    15721 acccgcccac cggggactcc ggcggccggg gcggcccggc tccggctgga ggcgtcaggc
    15781 ctcggcgggc accccggccg gggcggccac cggcagccgg accgggtgcc cggcggcgtg
    15841 cagcgcgtcc ttgacgtcgc cgatgctcag ctcaccgaag tggaagacac tggccgcgag
    15901 caccgcgtcg gcgcccgccg ccacggccgg cgggaagtgg gccaccgccc cggccccgcc
    15961 ggaggcgatc accggtacgt cgacgaccgc ccgtaccgcg cggatcagct ccaggtcgaa
    16021 gccagccttc gtgccgtcgg cgtccatcga gttgagcagg atctcgcccg cgccgagcac
    16081 ggccacccgg tgcgcccact ccaccgcgtc caggccggtg ccccgccgtc cgccgtgggt
    16141 ggtcacctcg aacccgctgt cggaggtgcc ggccggtgcc cgccgcacgt cgagggagag
    16201 cacgagcacc tgccggccga accgctcggc gatctcggcg atcagctcgg gacgggcgat
    16261 ggcggcggtg ttcactccca ccttgtccgc gcccgcccgg agcagcacgt ccacgtcggc
    16321 gacgcggcgc acgcccccgc cgacggtgag cggaatgaag accgactcgg cggtccggcg
    16381 gaccacgtcg agcatggtgc cccggtcgtc ggaggaggcg gtcacgtcga ggaaggtcag
    16441 ctcgtccgcg ccggcccggt cgtacgccgc ggccagctcg accgggtcgc cggcatcccg
    16501 caggtcgacg aagttgacgc ccttgaccac gcgtccggcg tccacgtcca gacagggaat
    16561 gacccgtacc gccaccgtca tgccgcgagc ctaccgccca ccccgttccg ccaccccggc
    16621 ccgccgacgc ccccagcccg tggcacgcgc cgggggttgg ggtgtctgca ggggccccct
    16681 cctcgacaaa aagcggtaac aggggacccc tgctaccacc cggccgggcc ggggtgaagt
    16741 ggggtggggt gggcgggact cggttaccac ccgggcgggg tggtggagct cacaggcgga
    16801 cgagcatctt gccgaggttc tcgccgcgga gcaggcccag gaaggccgcc ggggcgttct
    16861 cgatgccgtc gaccacggtc tcgtcctggt gcagccgacc ctcgcgcagc cagccggatg
    16921 cctcctcgac gaactgctcg cgcaggtggc cgtaggagtt gacgaggaac ccgcgcaggg
    16981 tgagctgctt gccgatcacc agcgccaggt tgcgcggggc gggcggcggc tcggtggcgt
    17041 tgtagtgggc gatcatgccg cagatcgccg cccggccgtg cgggcgcagc gcggcgatcg
    17101 ccgcctccag gtggtcggca ccgacgttgt cgaagtacac gtcgatcccg ttcggggcgg
    17161 cggcgcggag ctggtcgcgg accgggccgt cgtggtagtc gaaggcgacg tcgaagccga
    17221 gcgcgcgcag gcgctcgacc ttggcgggtg agccggcgct gccgaccacc cgcgccgcgc
    17281 cccgcagctt cgcgatctgc ccgaccaggc tgcccaccgc accggcggcg gcggagacga
    17341 acacggtctc gcccgcacgc atgccggcga cctccagcag gccggcgtac gcggtcaggc
    17401 cggtcatccc gagcacgctc aggtacgcgt tcaccggcgc gagcgccggg tcgacccggc
    17461 gggcggagcc ggcgtcgagc agggcgtact cccgccagcc gaggccgtgc agcaccaggt
    17521 caccgggggc gtacccctcg gcccggctct gcaccacctc gccgatcgcg ccgccgtcga
    17581 gcggggcgtc gagccggaac ggcgggacgt aggacttcac gtcgttcatc cgcccccgca
    17641 tgtacgggtc gacggacatg accacgttgc ggaccacgag ctgaccgtcc ccggcggtcg
    17701 ggacggacgt ggagaccaga cggaagttct ccggggtggg ccagccgtcc ggccgggacg
    17761 cgaggtggat ctcccggttg accgtcatgc ggcgtcccgg acggtcaggg tggtgtcgat
    17821 gttgccccgg gtggcgttgg agtacgggca cacctggtgg gcccgggcga ccaggtcctc
    17881 ggcgacggca cgcggcaccg acggcaggtc gaccaccagg ccgacggtga gggtgaagcc
    17941 gccgtcgccg ttcgggccga tgcccacctc ggcgtccacg accgagccgc tgacgtcggc
    18001 cttggccctg cgggcgacca ggcgcagcgc ggagtggaag caggcggcgt acccggcggc
    18061 gaagagctgc tcggggttgg ccgcgccgcc ggcgccaccc atctccttcg ggacggccag
    18121 atcgaggtcg accgtgccgt cggaggtgcg gacgtggccg tcgcggccgt cgccggtggc
    18181 gtgggcggcg gcggtgtaga gcacctgcat ggtggtcact tccccttgtg tcggtggatg
    18241 gtctcggtca cccgggtgag ggtgtcgcgg agcgcgacca gctcgtcgag ggtgagtccg
    18301 gtggacgcgg cgacccggtg cggcacgtcg caggcccggt cccgcagcgc gcgcccggcg
    18361 gcggtcagct cgatctccac ccgccgttcg tcgcgggcgg cacggcggcg gaccagcagg
    18421 cccgccccct ccagccgctt gagcagcggg gagagcgtgc cggagtcgag ccgcaggtcg
    18481 gcgccgagtt cggagacggt cggggcggcc tcgccgcgtt cccagagcac cagcagcacc
    18541 aggtactgcg ggtaggtcag ccccagctcg tcgaggatcg gccggtagac gtcggtgacc
    18601 gcccgggagg cggtgtagag cgcgaagcac acctgtcggc gcagcaccag gtcgtcgtcc
    18661 acccggcaaa ggtagcgcgc aatttgattg cgcacaactc aattgggtgg gcgggacccg
    18721 gcccggtggg tgccgggccg gggtgccggt tcaggcgtcg gcgagcacgc gcagcgcctc
    18781 ggccaccgtg aacgcgccgg cgtacagcgc cttgccggcg atcacgccct ccacgccgac
    18841 cggctccagg gtggccaggg cccgcaggtc gtccagggtg gagacaccgc cggaggcgat
    18901 caccggggcg tcggtacgcg cgcagacctc gcgcagcagg tccaggttcg gcccgcgcat
    18961 ggtgccgtcc ttggtgatgt cggtcaccac gtaccgggac gcccccgcct tgtccagccg
    19021 ctccagcacc tcgaagaggt cgccgccgtc gcgggtccag ccccgcgcgg cgagggtacg
    19081 gccgcgcacg tccagcccga tcgccacccg gtcgccgtac tcgccgcaga tccggtcgca
    19141 ccactgcggg tcctccaacg cggcggtgcc gatgttgacc cgggccgcac cggtggccag
    19201 tgcggcgcgc agcgaggcgt cgtcccggat cccgccggac agctccacct tcacgtccag
    19261 ccgccgcacc acctcggcga gcagcggggc gttcgacccc cgaccgaagg cggcgtcgag
    19321 gtccaccagg tggatccact ccgcgccgtc gttctgccag gccagcgccg cctccagcgg
    19381 gtcgccgtag gcggtctcgc taccggcggc gccctgcacg agacggacgg cctgcccgtc
    19441 ggcgacgtcc acagcgggca gcagggtcag actcaacgtg ttctcctcgg atcaggtacg
    19501 gcggtccagg gcgatcacca cgatcgccgg gagtacgagc agtagtagca ccatcagcag
    19561 cacccgcagc gcgggatcgg gcaccagcgt ccagatcgac cccagcacgg ccagggtcag
    19621 caccacgatg ccggcgcgct cggcccggct ccggcgggcc agcaggcggc cggtacgccg
    19681 ccgccgccaa cccggcctca gccggcgcag cagcgcgcga cggcgttccc gccgggccac
    19741 ccgacgggcc cgtacggccc ggtcccgttc ccgttcggcc tcccgggcgg cccgcagccg
    19801 ggcccgttcc ttgctcaccg gccgacccga ccgggctcag ccatcgccgg tcacagcgtg
    19861 cccagccagt tgcgcagcag cagggcaccg gtgtcggccg acttctccgg gtggaactgg
    19921 gcggccgaga gcgcgccccg ctccacggcg gcgacgaagt cgtccccgtg ccgggcggtg
    19981 gtcaccacgg ccccggctgc agtcagcgcc gccacgtcgg cgacggcgta cgagtggacg
    20041 aagtagaacc gtcccccctc cggcagcccg gcgaagagcg tcgagccggc cggcgggcgc
    20101 agcgtgttcc agcccatgtg cggcaaccgg gtggcggcca gccgggtcac cccgcccggc
    20161 agcagaccca gcccccgggt caccaccccg tgctcctcac cgtgggagaa gagcacctgc
    20221 atgccgacgc agatgccgag caccggtcgc ccggcggcga cccggtcggc gatcaccggg
    20281 ccggcaccga gcgcctcgat cccggccatg caggcggcga aggccccgac acccggcacc
    20341 accagcccgt cggcggcggc cgcggcggtc aggtcggcgg tgaccgtcac gtccgcaccg
    20401 gcgcgctgca acgcccgctc ggcggaccgc aggttgcccg acccgtagtc gagcaccacg
    20461 acgcggctca cgacgtcacc aacgggatca gccagagcac gcccccgacg cctgcgagca
    20521 gggcgagcag ggcggtcacc acgaccacgc cccgggcggc gccctgccgg tgcagggaga
    20581 ccaccccgcc ggccaggagg ccggcgagga tcagcagcaa cgaggggagc accgtgtcca
    20641 tcagcggcac cccgttccgg cggtcacagc gcccccttgg tgctcggcac cacgccggcc
    20701 gagcgcgggt cgatcgcggt ggcctcgcgc agcgcccggg agaccgcctt gaactgcgcc
    20761 tccaccacgt ggtgcgcgtc cgggtggccg ccggggcggg ccgcccggag cacgtccacg
    20821 tgcagggtga tccgggccgc ctgcccgaac gactcccaga tgtgccgggt catgctggtc
    20881 gggtagaccg gcccgatgta cggggtgagc agcggctcgt cgtgcaccac gtacggccgg
    20941 ccggagaggt c
//
