LOCUS       NZ_AP023438            25069 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Micromonospora sagamiensis strain JCM 3310 chromosome, complete
            genome.
ACCESSION   NZ_AP023438
VERSION     NZ_AP023438.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora sagamiensis
  ORGANISM  Micromonospora sagamiensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Micromonosporales; Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 6930736)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu
            Genome Coverage                   :: 62X
            Sequencing Technology :: Illumina HiSeq X Ten; PacBio Sequel II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014680085.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:12:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,941
            CDSs (total)                      :: 5,859
            Genes (coding)                    :: 5,751
            CDSs (with protein)               :: 5,751
            Genes (RNA)                       :: 82
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 108
            CDSs (without protein)            :: 108
            Pseudo Genes (ambiguous residues) :: 0 of 108
            Pseudo Genes (frameshifted)       :: 30 of 108
            Pseudo Genes (incomplete)         :: 88 of 108
            Pseudo Genes (internal stop)      :: 5 of 108
            Pseudo Genes (multiple problems)  :: 15 of 108
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:39:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 641761
            Orig. end                         :: 666830
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023438.1.
            Genome sequencing and analysis were conducted under the Global
            Catalogue of Microorganisms (GCM) 10K type strain sequencing
            project (http://gctype.wdcm.org). The genomic data are also
            available at http://gctype.wdcm.org/sequencing/GCM10017556
            Annotated by DFAST v.1.2.7 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25069
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25069
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22566
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22566
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12566](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12566)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    850..865
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            1000..1998
                     /locus_tag="IGA62_RS02395"
                     /old_locus_tag="GCM10017556_04940"
     CDS             1000..1998
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019121.5"
                     /locus_tag="IGA62_RS02395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_04940"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_145816604.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 8.3e-07,
                     bitscore: 27.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSPSPATRLCWIYPDRGTAWQRDYEEQGVWGAYREIAATLGLR
                     MSLHKPEEVAVDATDPARPRVYLNGERVTPEDTIFVTAIYSLPHQVVDVANQVYLFTVL
                     ETLGFYLPIPPWLTYLGEDKLATVVHLAQSPVPPLPTVRVASGREAMTGHYDEAFAGLD
                     YPMIIKPANWGMGLGISVVHNVHDLRGVIGLAGGSDTPLVAQPYVRDPRETRVYVVDGR
                     AHTVLQGGKEGYCLMVTKTVGGRHDRAFTDLPAELDSTVAYLTERLPTPYFSVDFISDG
                     ERFWLSEIEVDGAIGFSMDAEQDVVARSLVTARFEAYQRGHARWLADRESR"
     gene            1995..3152
                     /locus_tag="IGA62_RS02400"
                     /old_locus_tag="GCM10017556_04950"
     CDS             1995..3152
                     /NRPS_PKS="Domain: AMP-binding (51-216). E-value: 3.1e-15.
                     Score: 47.6. Matches aSDomain:
                     nrpspksdomains_IGA62_RS02400_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="IGA62_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_04950"
                     /product="AMP-binding protein"
                     /protein_id="WP_145816602.1"
                     /sec_met_domain="AMP-binding (E-value: 7.4e-13, bitscore:
                     46.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIGELPWEGLLVQAKELAAIGGAPVPDSVTGLADLTVTGPAEIL
                     AVSRHLTADGGAAVMSSGGTTGRPKLTFVAHHQAIDRLHAVWRPLEPGNVLLNLFTPGR
                     LWASHYYMQTLAERSRCHVLPAGPYGPDEVADWLPIFREVGVDALAGTPTALADLARGV
                     LDHGVDLDVRRVIWMAEPWTPAKEATVRAAFPQARFWANYGSVETFVIATNDPGCDLST
                     LHLMPDQLLELDDDGALLSRTGDGWTVPTVRYRLGDRVAAASCRCGRPQALRVVGRADD
                     AIKLYGSLFGIGEILAGVRENPGVTEAQLVLTRSPESRHSVRQMSVHFTGEADPAQVRD
                     WLVRTWYDLPPILHTYPEAVTVERVARLHRVERTNKVPPMIWRDR"
     aSDomain        2148..2642
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS02400_AMP-binding.1"
                     /evalue="3.10E-15"
                     /label="IGA62_RS02400_AMP-binding.1"
                     /locus_tag="IGA62_RS02400"
                     /protein_end="216"
                     /protein_start="51"
                     /score="47.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="TADGGAAVMSSGGTTGRPKLTFVAHHQAIDRLHAVWRPLEPGNVL
                     LNLFTPGRLWASHYYMQTLAERSRCHVLPAGPYGPDEVADWLPIFREVGVDALAGTPTA
                     LADLARGVLDHGVDLDVRRVIWMAEPWTPAKEATVRAAFPQARFWANYGSVETFVIATN
                     DP"
     gene            3149..4600
                     /locus_tag="IGA62_RS02405"
                     /old_locus_tag="GCM10017556_04960"
     CDS             3149..4600
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="IGA62_RS02405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_04960"
                     /product="MFS transporter"
                     /protein_id="WP_145816600.1"
                     /transl_table=11
                     /translation="MTTRLRGNPWAILAVLCLAYFMSQLDIAVLAIAIPEIVRDLDASL
                     DQVVWALSSYILALAALLITAGRLGDLYGRRRIFLLGVAVFTVFSLAGGLADGPGQLIA
                     ARAVQGVGAALFVPQTMALLVEAFPPERRGMALGIRGGVGGTAAVLGPVVGGFLVSSLD
                     WRWVFFVNIPVGVVMLALAAATIPATGGRKEHRLDLAGVMLATAFLLLLAFGLSQGARY
                     SWNGGIWAVIAAGLVLFAVFLAQQRRRQDREPLVPFALFRDRNFAVMNVFSVVVSLTVI
                     GLIVVLSVTFQSVLEFGAWRAGLLLMVASLLSVVFDPVAGKLSEKVEGRHLLLFGMAAT
                     VAGLLWTFTQTRSEAGWAGLVAPMVVIGIGNAFLFTPLATVALHRVRPESAGGAAGVLV
                     TSMQVGSMVGTAVMGAVLREGSGTAPTVDTIRDVLLLLVGTAAVGAVICLAAERSSTPA
                     DTAPPAEGTPPVGTAPAVRQSEDAA"
     gene            4597..5826
                     /locus_tag="IGA62_RS02410"
                     /old_locus_tag="GCM10017556_04970"
     CDS             4597..5826
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGA62_RS02410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017556_04970"
                     /product="acetyl-CoA carboxylase biotin carboxylase subunit
                     family protein"
                     /protein_id="WP_145816598.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 7e-06, bitscore:
                     24.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDVPRYLVLNRFGNEFGEYHRYLRPHEGRMAYLTLAAGTSVLDT
                     ANALDTVVVTDLDFHTVLPVARALTARLGSFSGVVGISEWDLLTAARLREALGLPGWNH
                     EFTRRFRDKPYMKERVAAAGLRTPRFTELVPGTDPTLLAKDIVTSLGLPVIVKPRSGVA
                     SAGVRRVDTAEQLAEALTGLDLAAHECEELIEGRVLHVDGVRRGGRFHFVSASAYVNTC
                     FDFANGSPLGSVLLDPGPLRDRVTDFAGRCLDALDLVDGPFHLELFHTPGDELVFLEVG
                     LRPGGGPLPDLHRELFGIDLLAETFRLTVGLPPATPASAHTEPTGGGWLIFPEPRPLPS
                     RVVARTSLRGVVDGIHAEVLPEVGEVFDGTGGYLHVGGAFRFRGPDEATVRRDVLRTIE
                     CYRLTTEPAP"
     gene            complement(5881..6480)
                     /locus_tag="IGA62_RS02415"
                     /old_locus_tag="GCM10017556_04980"
     CDS             complement(5881..6480)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072004.1"
                     /locus_tag="IGA62_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_04980"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_145816596.1"
                     /transl_table=11
                     /translation="MDYGHSEQPAETVPTAIKILIAGGFGVGKTTMVGAVSETRPLRTE
                     EVLTESGVGIDDLSGVEDKATTTVAMDFGRITISDDLVLYLFGTPGQDRFWFVWDELAL
                     GALGAVVLADTRRLADCFPSIDYFEGRGTPFVVAVNCFEGARRYQLDEVQAALNLDPDV
                     PVLLCDARQRQSSKEVLITLLEHAMKVRAARSAAGG"
     gene            complement(6461..6847)
                     /locus_tag="IGA62_RS02420"
                     /old_locus_tag="GCM10017556_04990"
     CDS             complement(6461..6847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072005.1"
                     /locus_tag="IGA62_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_04990"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_091460300.1"
                     /transl_table=11
                     /translation="MTVTGGPMEEQWVDDHAGPVVRPYAVTRGRARPVTGTFDLISLVT
                     AIQSDVTPEAGLGPEHLAIVGLCQRMQSVAEIAAHLDLPVGTIRVLLGDLVARNLVQVR
                     EPRATGGLPDDSIFEAVINGLRAL"
     gene            complement(6854..7279)
                     /locus_tag="IGA62_RS02425"
                     /old_locus_tag="GCM10017556_05000"
     CDS             complement(6854..7279)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007462632.1"
                     /locus_tag="IGA62_RS02425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05000"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_145816593.1"
                     /transl_table=11
                     /translation="MAQKTASSADLTWLLDDLVGRVKQAEHAIALSTDGLLMASSRGLS
                     RDDGEHLAAMAAGIQSLARGAGKRFGGGQVQQTIIEMQSSFLFVTAAGRNACLAVLASE
                     DADVGLIAYEMAMLVTRVGKYVASPSRLSEQSATAEK"
     gene            complement(7371..9902)
                     /locus_tag="IGA62_RS02430"
                     /old_locus_tag="GCM10017556_05010"
     CDS             complement(7371..9902)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788259.1"
                     /locus_tag="IGA62_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05010"
                     /product="sensor histidine kinase"
                     /protein_id="WP_145816592.1"
                     /transl_table=11
                     /translation="MGSRSTNLRTKVVALLASLVALWAFAAWVTVGDGFNLLGVQTLNA
                     RVFAPSEPLLLQLQKERRLSLAYLGRPEAGQLEALRAERDRTDELARAFEASAVNWRTE
                     IPASTEVERAVDNVLTGLDELSRTRTAIDDKSIDRATALTSYVEVVDAMFRLYDELGGL
                     DDQQVAHDTAALIELNRARELLSQEDALLHGALAAGRVTSAEQAQFAQLVGAQRYIAAS
                     TISALPVADRNRYQQMSQGEAHQRLRTLEDRVIQARNTESRPPVELDAWRSAVDPALQQ
                     LNDVVGAGGDDVVDRATPVAVGVITRLVLATGLGLLAVVASIIVSITTARALLRQLERL
                     REAAFQLARERLPNVVERLGRGEEVDVAAEAPPLEFGDDEIGQVGQAFNVVQETAIRTA
                     VEQAELRRNVRDVFLSLARRTQALVHRQLTLLDAMERRENDAEELEDLFRVDHLATRMR
                     RNAENLIVLSGSTPGRAWRRNVPMVDVVRGAVAEVEDYTRVNVLPLGQVSLAGRAVGDI
                     IHLLAELIENGLSFSPPHTTVEVRGQLVANGFALEIEDRGLGMSEEDLAAANERIVDQS
                     ELNLANATRLGLYVVSRLTERHGIRVHLKESPYGGTTAVVLIPLALVTADEEEPGAPGT
                     PHAGAVEPPVGPALIGTEPSGPRPALPVALAEPGSPRRVPEGTGDEPDQLPTRVRTTLE
                     RPRAPQDTPAESGTGLPTRSRLWSEQSALDGPTFPTGLPVATPRTEPARKVEHGGPTPC
                     PAAEPPRTESGLPMRVRQANLAPELRDETPVVDTPEDDEAVRPPEQVRRMMSSYQTGTR
                     RGRTDAARLLGGPARGPEPADAPDDEDRQAT"
     gene            complement(10001..11620)
                     /locus_tag="IGA62_RS02435"
                     /old_locus_tag="GCM10017556_05020"
     CDS             complement(10001..11620)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287419.1"
                     /locus_tag="IGA62_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05020"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_145816590.1"
                     /sec_met_domain="T2TS (E-value: 1.1e-77, bitscore: 260.2,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSILAAVGDLLGEMTATPTGQSSVSVYETGRLVSLSPWLTLHAAR
                     IRYLLDAEHPTGGWGGPGGYGLAPTLSATEGLLAALRRGDLAGTSDPLHRGAVAAVDRG
                     LAVLGDRLAAVPASALPDMPAIDLIVPALVEALTVHLDAMRDDPVTGLERWRTAPRLPL
                     PPGMTPTRLARVRAALTSGHPLPEKLMHALEVAGPAARRAAGVVPVGPGTVGASPAATA
                     AWLGVPDATTSAARAYLEGVVRQHGGPVPCTSPISVFERSWVLSTLSRAGVPLSAPPPV
                     LASLRDTLGPAGTATAPGLPVDADTTSVTLYALARAGQPVDPSSLRSFDTGEHFCTWPK
                     EDGASITTNAHVLDAVGWHLRHGGARAEHLAPVVRRLTTWLAERQAPEGSWSSDRWHAS
                     PYYATSCAVLALHGYGVGASVEPVVRRAVCWVLAGQHPDGSWGRWGGTAEETSYALQVL
                     LAAGQASSDQCAQAIARGWRWLVTMDGFDGGPALWHDKDLYRPSLIVRAAALAVTWWGR
                     TSAGPDPVEAGPSSRSAMIRIA"
     gene            complement(11676..12566)
                     /locus_tag="IGA62_RS02440"
                     /old_locus_tag="GCM10017556_05030"
     CDS             complement(11676..12566)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287420.1"
                     /locus_tag="IGA62_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05030"
                     /product="terpene synthase family protein"
                     /protein_id="WP_145816588.1"
                     /sec_met_domain="T1TS (E-value: 1.9e-11, bitscore: 42.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLNTQAAEAVEQGRICALAARGQRDLQKLAAGYPELFSGAPFDA
                     ALFGNIAMAMAFSAPWCTLEELRVTNRAVLWGFALDWQVDYLAKSRTEIDRLTETSLAV
                     VDGATPASDDPFARFFAELCADLAAAPAYPRLRDAWRAAVHRTLAAMAVEWEWRAARRD
                     LTGTLPTFEEYLANADNLACTVVNVAHWIHTGDDGTHRSLSRLVEASDEVQRVLRLVND
                     LGTYQRDLEWGDLNAIMLVADRAEVEQRVEVLTGRCHELLAPLAEECPRQATYLARQVG
                     FTSGFYRSTDFWGAR"
     gene            complement(12581..13903)
                     /locus_tag="IGA62_RS02445"
                     /old_locus_tag="GCM10017556_05040"
     CDS             complement(12581..13903)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788256.1"
                     /locus_tag="IGA62_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05040"
                     /product="cytochrome P450"
                     /protein_id="WP_145821847.1"
                     /sec_met_domain="p450 (E-value: 1.2e-70, bitscore: 237.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPALVRDPARALIDAGNRTGGNLARINLGSFRPYLVTHPEHVQH
                     VLRERAENYERAGDGLFWRPVKRLFGEGILGEGQIWSASRRMLQPMFTAKRVESMIDGM
                     AEAISDAVDELGTPSRVGRPVDIGAEQARIVCRAIMKVLFADKISVADAMRVVDAQDAI
                     ASAVIPRIVVPFAPLSLPMPGDRTFRRAVRVVDDVLVPIVRESRATAEEGDDIISTLWR
                     ARTDDGRQLDERQVRNDTVAMFAATTETTINVLTWLWPHLDEHPEVADQLYEEINRVVG
                     DEPVRREHLGELRYTRMVLDELLRLYPIGWLIPRRAVAADVVGGVRIEAGATVVASPLI
                     TQRMSAFWDRPDEFDPERFRPERVRARHRYAHFPFGGGPHQCLGMYLFYLEAQLIVATM
                     LSRYRFRLAQPGVPGLRLAAALRPRRRVELTLTGAAPSAAA"
     misc_feature    complement(14080..14093)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.15"
                     /tool="antismash"
     gene            complement(14129..15049)
                     /locus_tag="IGA62_RS02450"
                     /old_locus_tag="GCM10017556_05050"
     CDS             complement(14129..15049)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025054.5"
                     /locus_tag="IGA62_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05050"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_145816585.1"
                     /transl_table=11
                     /translation="MTVTIRRFRPEDATDVAAVLRVAAPYWVFSAVALRWQAAHGAPAA
                     RHRMLLAEVDGEVVGVARTGLLHESAEPGLGYANLNVLPQRRGRGVGSALLAAAEERLR
                     AIGVRVAYAKVTDDPAAVGFAERHGYRRGRATTHLRLDLATGALPAPPALPGVRIASAA
                     TLAGDPRPLYEADLDASRDEPGDVGMDATGYADWRTTYWDRPDLDRTLTTVAICDGVVA
                     AFSFALTDGSIRFQSGMTGTRRAYRGRGLAGAVKRAALHRAAEAGFATALTSNDAGNEA
                     MLAINRRLGYVPVAAEWRYRRTLFR"
     cand_cluster    14206..25069
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    14206..25069
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[19205:20069](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      19206..20069
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            15128..15376
                     /locus_tag="IGA62_RS02455"
                     /old_locus_tag="GCM10017556_05060"
     CDS             15128..15376
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (33-44). E-value:
                     0.00024. Score: 12.6. Matches aSDomain:
                     nrpspksdomains_IGA62_RS02455_PKS_Docking_Nterm.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287422.1"
                     /locus_tag="IGA62_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05060"
                     /product="DUF2630 family protein"
                     /protein_id="WP_091460285.1"
                     /transl_table=11
                     /translation="MDDKTILNRIAELVDEEHRLRADAQSAQAGTDDDARARLRELEEG
                     LDQCWDLLRRRRAARQTHNDPESQGVRPVPEVERYLQ"
     aSDomain        15227..15259
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGA62_RS02455_PKS_Docking_Nterm.
                     1"
                     /evalue="2.40E-04"
                     /label="IGA62_RS02455_PKS_Docking_Nterm.1"
                     /locus_tag="IGA62_RS02455"
                     /protein_end="44"
                     /protein_start="33"
                     /score="12.6"
                     /tool="antismash"
                     /translation="DARARLRELEE"
     gene            complement(15462..16406)
                     /locus_tag="IGA62_RS02460"
                     /old_locus_tag="GCM10017556_05070"
     CDS             complement(15462..16406)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018583044.1"
                     /locus_tag="IGA62_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05070"
                     /product="serine protein kinase RIO"
                     /protein_id="WP_145816583.1"
                     /transl_table=11
                     /translation="MREHDIDPSARERRPRGKRRFDDDETPFLKHGRQPRPASVSDDGD
                     PDHPLVGDRWSTWDQAIHGPEPYPDWVVTELAAQDTELGVLKTGKEADVHLVRRAVPDT
                     DRSCLLAVKRYRAPEHRLFHRDAGYLEGRRVRRSRETRAMAGRTSFGRQMIAGQWAAAE
                     FAVLSRLWEIGVSLGTVAVPYPVQLIGTELMLEFIGDVDEGQAAPRLAQLRPEPDELRG
                     LWEQLVDVLVVLARTGHAHGDLSPYNLLVHDGRLVLIDLPQAVDVVANPQGAEFLARDV
                     RVVSTWFAARGLPAELTDPAALTGQLLREAGLR"
     misc_feature    16387..16401
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(16600..17451)
                     /locus_tag="IGA62_RS02465"
                     /old_locus_tag="GCM10017556_05080"
     CDS             complement(16600..17451)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287425.1"
                     /locus_tag="IGA62_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05080"
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="WP_145816581.1"
                     /transl_table=11
                     /translation="MTSLPSATLTVAAVQADPVPGDVAGNASSAARLVRRAVDSAARLV
                     VLPELFLSAYHPPVLGADPAGTDVAAGPDALVADPRLDPVRAVARETGTVVVLSAAVRH
                     PDQRRTISALVVDRAGTVRVGYDKQQLWSEERKLFTPGRRGATLTVDDWRFGLGICYDG
                     CFPEHGRAAADDGAHGYLCPSGYVVGSAHRRDVYYAARALDNTMYVVFANSVDGVDPWR
                     FNGGAAVYDPEGRCLVRGADTGEAVLVATLDPEQLARTRADHPMLADRLPDQGPERNRV
                     TG"
     misc_feature    17481..17494
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.39"
                     /tool="antismash"
     gene            17545..18117
                     /locus_tag="IGA62_RS02470"
                     /old_locus_tag="GCM10017556_05090"
     CDS             17545..18117
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018727348.1"
                     /locus_tag="IGA62_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05090"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_091460277.1"
                     /transl_table=11
                     /translation="MPRVSQDQLDARRQEILAAARACFARHGYEGATVRRLEEATGLSR
                     GAIFHHFRDKDSLFLAVAEDDAAAMVETVARNGLVQVMRDLLARAMSPDTAGWLGSQLE
                     VSRRLRTDPSFARRWAERSAAIAEATRERLARQREAGVLREDVSIDVLARFLELAYDGL
                     VLHLAMGRPAGDLGPVLDLVEEAVRRR"
     gene            18289..19209
                     /locus_tag="IGA62_RS02475"
                     /old_locus_tag="GCM10017556_05100"
     CDS             18289..19209
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019032912.1"
                     /locus_tag="IGA62_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05100"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_145816579.1"
                     /transl_table=11
                     /translation="MTLLAAPGDTWGISGPTFLAGYLLVAALVVLGSTLHRAWLFDGRR
                     PPGYDHLGPEQAAYLNGGARLAVYSSIGALRSVGAVGADRRKLLRATGPLPAGATALDQ
                     AVHHAAGRGVRTGDLPQDHWVATALGQLRQDLENRGLALDADRRRAARFGPALLFLLLL
                     VGVLRLFAGIRNDQPVGFLVAAMVVLAVIFVVQAARVPYRTRAGRTALSNLRAHYRYLT
                     PSASPAYATYGAAGAAMGVALFGAATLWAFDPDFADAAAIQRQAAGSGTSAGGGDSGGG
                     DSGGSSCGGGSSCGGGGGCGGGCGG"
     gene            19206..20069
                     /locus_tag="IGA62_RS02480"
                     /old_locus_tag="GCM10017556_05110"
     CDS             19206..20069
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788250.1"
                     /locus_tag="IGA62_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05110"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_145816577.1"
                     /sec_met_domain="DUF692 (E-value: 7.5e-80, bitscore: 266.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPPRTTGSVGASRAGPPAGVGIGWRPEIAGFVADLPGLRFVEV
                     IAEGVAPAGPPPAGLAELRAAGVTVVPHGVRLSLGGADPVEPTRVAHLAAVADLLDAPL
                     VSEHIAFVRAGGVEAGHLLPLPRTREAVEAVAANVRRAQADLPVPIALEPIAALFDWPD
                     DELDEGAFVTEILERTDALLLLDIANVYANARNRGTDPVALLDRLPLERIAYVHVAGGA
                     EHDGLYHDTHTDPVPPEVLDLVGALCARHRPPALLLERDGRYPPAAALRAELDALATAA
                     GWPVIT"
     gene            20066..20515
                     /locus_tag="IGA62_RS02485"
                     /old_locus_tag="GCM10017556_05120"
     CDS             20066..20515
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018722900.1"
                     /locus_tag="IGA62_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017556_05120"
                     /product="hypothetical protein"
                     /protein_id="WP_145816575.1"
                     /transl_table=11
                     /translation="MSGSLADRQAALVAALVAGADAPPGFDTHRLDAARTALLRKRAGE
                     VGRHWPLLAAGLGRAWPATFLGWAAGRPTRGGLRDGWDLARTLRADGTLPPMAAGELAV
                     REATSHYDGERPPRLRRLPAVVRVGDAVAVQLAGRVRLHGTRHPG"
     gene            complement(20541..21305)
                     /locus_tag="IGA62_RS02490"
                     /old_locus_tag="GCM10017556_05130"
     CDS             complement(20541..21305)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGA62_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017556_05130"
                     /product="hypothetical protein"
                     /protein_id="WP_186499765.1"
                     /transl_table=11
                     /translation="MRAMFGRLLADVRHWRNLDLYTVALVTLVVAALTMVGADLPDDVR
                     WSVLFGALGLLVLRTAAATWTAGSSDRVLLDRSAFLTDPVNERLRGAREVLVFAPTAEN
                     FLNRERCELLRTGPLARRDGSVRVVVLGQSETEDVSAVVRQLDLLLEIPVQQVADSLRE
                     THQRLASMARWQVPGAFGYRTLPFSPGFSIVAVDPSGRDGFVVVEFHGFRSDTITSRMH
                     LRLVRGRDDPWYDYWLEQFHAIWRSAEPRQGA"
     misc_feature    complement(21524..21539)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.04"
                     /tool="antismash"
     misc_feature    22269..22283
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    complement(23528..23541)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    24401..24416
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.01"
                     /tool="antismash"
     misc_feature    24815..24830
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    complement(25013..25027)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.18"
                     /tool="antismash"
ORIGIN
        1 cgtggcccgg cccgagccgg acgtggcccc ggcggaggcc gaggcgtcga tccgcgccgt
       61 gctcgaccgg cacggcctga ccggtccggt ccacctcgtg gcggccctcg cctacaccgc
      121 ggtcggcaag ccgcacaagt cactcctgcg ccgtcagtgg gtgtcctcgc cggaagggga
      181 aaccgccgtg cccgcacacc ggagcgcgaa cctgctccgc caccgccgac tgagccggac
      241 acccaccctg ctcttcatcc cggggctggc gatgacctcg gcctacttcg acgaggtggc
      301 ggccgacctg agccaggacc acgacgtggt gaccgtggat ctgcccggtc acggggacac
      361 ccccgatccg tcgccgggct ggaccatcga cgacgcggca cgggccgtcc gggcggtcgt
      421 cgaccgcctc gaactgcggg acgtgacgct cgtcggctgg tcgctcggcg cgggcgtcgc
      481 ctggacctac ctggacctct tcggtacgga ccgggtgtcg aagctggtct cggtcgagat
      541 gtcgccacgg atcctggccg gcccggactg gacacacgcc gccttcggcg ggctcgacgc
      601 ggccggcgcg atccagaccc agcgcgccat ctggaccgat ccgcaggggt tcctggacga
      661 tctggtgcgc cgctccttcg ccgccgggtc cacgcccgac ccggcccgac tccagcggct
      721 cgtcaccgag acgcggagct gttcggtcgt ctccgtgctg gcgctctggc tcgacgtgct
      781 gacccgggac tggcgggagc agttgaccac gaccacgctg cccacgctgc tcgtgcacgg
      841 cgcgcagagc caggtctacc ccaccgacgt cggggcgtgg ctgcaccggg ccatgcccga
      901 cgcccggctg gcgaccttcg cgcacagcgg gcacatgccg ttcctggagg agcctgagaa
      961 gttcacctcg gtgctccgcg acttcgtcaa ggagaaccgt tgaccacctc gcccagcccc
     1021 gcgacgagac tgtgctggat ctatcccgac cgcggcaccg cctggcagcg cgactacgag
     1081 gagcagggcg tctggggcgc ctaccgcgag atcgccgcca cgctcggcct acggatgagc
     1141 ctgcacaagc cggaggaggt cgcggtcgac gcgaccgatc ccgcgcggcc ccgggtgtac
     1201 ctcaacggtg agcgggtcac gccggaggac accatcttcg tcacggccat ctactccctg
     1261 ccgcaccagg tggtcgacgt cgccaaccag gtctacctct tcaccgtcct ggagacgctc
     1321 ggcttctacc tgccgatccc accctggctc acctacctcg gcgaggacaa gctggccacc
     1381 gtcgtgcacc tggcgcagag cccggtgccg ccgctgccca cggtccgggt ggccagcgga
     1441 cgcgaggcga tgaccgggca ctacgacgag gccttcgccg gcctcgacta tcccatgatc
     1501 atcaaaccgg cgaactgggg catgggcctc ggcatctcgg tggtgcacaa cgtgcacgac
     1561 ctgcgcggcg tgatcggcct ggccggtgga tccgacacgc cgctggtggc ccagccctac
     1621 gtccgggacc cccgcgagac ccgggtgtac gtcgtcgacg ggcgggcgca caccgtgttg
     1681 cagggcggca aggagggcta ctgcctgatg gtcaccaaga ccgtgggggg ccggcacgac
     1741 cgggcgttca ccgacctgcc ggccgaactc gacagcaccg tcgcctacct gaccgagcgc
     1801 ctgcccacgc cgtacttctc ggtcgacttc atctccgacg gcgagcggtt ctggctctcc
     1861 gagatcgagg tggacggggc gatcgggttc tccatggacg ccgagcagga cgtcgtcgcc
     1921 cggtccctgg tcaccgcccg gttcgaggcg taccagcggg gtcacgcgcg ctggctggcc
     1981 gaccgggaga gtcgatgatc atcggggagc tgccctggga ggggctgctg gtacaggcga
     2041 aggagctggc cgcgatcggt ggggcgccgg tgccggactc cgtcaccggg ctggccgacc
     2101 tcaccgtcac cggcccggcc gagatcctcg cggtgtcacg gcacctcacc gccgacggcg
     2161 gcgcggcggt gatgtccagc ggcggcacca ccggacgacc gaagttgacc ttcgtcgccc
     2221 accaccaggc catcgaccgg ctccatgccg tctggcgacc gctcgaaccg ggaaacgtgc
     2281 tgctcaacct cttcacgccg ggccggttgt gggcgtcgca ctactacatg cagacgctgg
     2341 ccgagcgcag ccggtgccac gtcctgcccg ccggcccgta cggaccggac gaggtcgcgg
     2401 actggctgcc catcttccgg gaggtcggcg tcgacgcgct ggccggaacg cccaccgcgc
     2461 tggccgacct ggcccggggg gtgctcgacc acggcgtcga cctcgacgtc cgccgcgtga
     2521 tctggatggc cgagccgtgg acccccgcga aggaggcgac cgtgcgggcg gccttcccgc
     2581 aggcacgctt ctgggcgaac tacggttcgg tggagacctt cgtcatcgcc accaacgacc
     2641 ccggctgtga cctgtcgacc ctgcacctga tgccggacca gctgctggaa ctcgacgacg
     2701 acggggcgct gctctcccgt accggcgacg ggtggacggt gccgaccgtc cgctaccggc
     2761 tcggcgaccg ggtcgcggcc gcctcctgcc ggtgtggacg gccgcaggcg ctacgcgtgg
     2821 tcggccgggc cgacgacgcc atcaagctct acggctcgct cttcggcatc ggcgagatcc
     2881 tcgccggggt gcgggagaat cccggcgtga ccgaggcgca gctcgtcctc acccgcagtc
     2941 cggagtcacg gcactcggta cggcagatga gcgtgcactt caccggggag gccgatccgg
     3001 cgcaagtccg ggactggctg gtccggacct ggtacgacct tcccccgatc ctgcacacct
     3061 acccggaggc ggtgaccgtc gagcgggtcg cgagactgca ccgggtggaa cggacgaaca
     3121 aggtgccccc gatgatctgg cgtgaccggt gacgacgaga ctgcgcggca atccgtgggc
     3181 catcctggcc gtgctgtgcc tggcgtactt catgtcccag ctggacatcg cggtgctcgc
     3241 catcgcgatc cccgagatcg tgcgggacct ggacgcctca ctggaccagg tggtctgggc
     3301 gctgagcagc tacatcctcg cgctggccgc cctgctgatc acggcgggcc gcctcggcga
     3361 cctctacggg cgcaggcgga tcttcctcct cggcgtcgcg gtgttcaccg tcttcagtct
     3421 cgccggtggc ctggccgacg gtccgggcca gctcatcgcc gcccgcgcgg tccagggggt
     3481 gggcgcggcc ctcttcgtcc cgcagaccat ggccctgctg gtggaggcgt tcccgccgga
     3541 acggcgcggc atggcgttgg gcatccgggg cggcgtcggc ggcacggcgg ccgtgctcgg
     3601 cccggtcgtc ggcggattcc tggtgagcag cctcgactgg cgttgggtct tcttcgtcaa
     3661 catcccggtc ggcgtggtca tgctggccct cgccgcggcg accatcccgg cgaccggtgg
     3721 gcgcaaggag caccggctcg acctcgccgg tgtcatgctg gccacggcct tcctgctcct
     3781 gctggccttc gggctcagtc agggcgcgcg gtactcgtgg aacggcggga tctgggcggt
     3841 gatcgcggcc gggctggtgc tcttcgccgt cttcctggcg cagcagcggc gccgccagga
     3901 ccgcgaaccg ctggtgccgt tcgcgctctt ccgggaccgc aacttcgcgg tgatgaacgt
     3961 cttctccgtc gtggtctcgc tgaccgtgat cggtctcatc gtcgtgctct cggtgacctt
     4021 ccagtccgtg ctggagttcg gtgcgtggcg ggccgggctg ctgctcatgg tggcgtcgct
     4081 tctctcggtc gtgttcgacc cggtggccgg caagctctcg gagaaggtcg agggccggca
     4141 cctgctgctc ttcggaatgg ccgccacggt cgccggtctg ctctggacgt tcacgcagac
     4201 ccggtcggag gccggctggg ccggactggt cgcgccgatg gtggtgatcg ggatcggcaa
     4261 cgccttcctc ttcaccccgt tggccaccgt cgcgctccac cgggtccggc cggagtccgc
     4321 cggaggcgcc gccggggtgc tggtcacgtc gatgcaggtg ggctcgatgg tgggcaccgc
     4381 cgtgatgggc gcggtgctcc gggagggcag cggcaccgcg ccgaccgtgg acaccatccg
     4441 cgacgtcctg ctgctcctgg tcgggacggc ggcggtcggc gcggtgatct gcctggccgc
     4501 cgagcgctcc tccacaccgg ccgataccgc accaccggcc gagggcacgc caccggtcgg
     4561 gaccgcgccc gccgtccggc agagcgagga tgcggcatga gcgacgtacc gcgctacctg
     4621 gtcctcaacc ggttcggcaa cgagttcggg gagtaccacc ggtatctccg gccgcacgag
     4681 ggacggatgg cctacctgac cctggccgcc ggcacgtcgg tcctggacac cgcgaacgct
     4741 ctcgacaccg tcgtggtgac ggatctcgac ttccacacgg tgctgcccgt ggcccgggca
     4801 ctgaccgcga ggctggggtc cttctccggc gtcgtcggga tctccgagtg ggatctgctg
     4861 accgccgccc ggctgcggga ggcgctgggg ctgcccgggt ggaaccacga gttcacgcgg
     4921 cgcttccgcg acaagccgta catgaaggag cgcgtggccg ccgccgggtt gcgtacccca
     4981 cggttcaccg aactcgtccc cggtacggat ccgacgctgc tcgcgaagga catcgtcacc
     5041 agcctggggc taccggtcat cgtcaagccg cgctcggggg tcgcctcggc cggggtgcgg
     5101 cgggtggaca cggccgagca gctggccgag gccctgaccg ggctggacct ggccgcgcac
     5161 gagtgcgagg agctgatcga gggccgggtg ctgcacgtcg acggggtacg ccggggcgga
     5221 cgcttccact tcgtgagcgc ctcggcgtac gtgaacacct gcttcgactt cgccaacggc
     5281 agccccctgg gatcggtgct gctcgacccg ggcccgctcc gcgaccgggt gaccgacttc
     5341 gccgggcgct gcctggacgc actggatctg gtggacggtc cgttccacct ggaactgttc
     5401 cacacccccg gcgacgaact ggtcttcctg gaggtggggc tgcgccccgg tggcgggccc
     5461 ctgccggacc tgcaccggga actgttcggc atcgacctgc tcgcggagac gttccgcctg
     5521 acggtcggtc tcccgccggc cacccccgcc tcggcgcaca ccgagcccac cgggggtggt
     5581 tggctcatct tccccgagcc gcgtccgctg cccagccggg tggtcgcgcg gacgtcgctg
     5641 cggggtgtgg tcgacggaat ccacgccgag gtcctccccg aggtcggcga ggtcttcgac
     5701 ggtaccgggg gctatctcca cgtgggcggt gccttccgct tccgtggccc cgacgaggcg
     5761 acggtgcggc gggacgtcct caggaccatc gagtgctacc ggctgacgac cgaacctgcc
     5821 ccgtgaaccc cggttccggt ccccgtcgcg gcacccccgt tcccggtcac cggcctacgg
     5881 tcagcccccg gcggcgctgc gcgcggcccg gaccttcatg gcgtgctcca gcagggtgat
     5941 gaggacctcc ttgctggact gccgctgccg ggcgtcgcag agcagcaccg gcacgtccgg
     6001 gtccaggttg agcgccgcct gcacctcgtc gagctggtag cgccgggctc cctcgaagca
     6061 gttcaccgcc accacgaacg gggtgccccg tccctcgaag tagtcgatcg aggggaagca
     6121 gtcggccagg cgacgggtgt cggcgaggac caccgcgccg agcgcgccga gcgccaattc
     6181 gtcccagacg aaccagaacc ggtcctggcc cggcgtgccg aagaggtaga gcaccaggtc
     6241 gtcgctgatg gtgatccggc cgaagtccat cgccacggtc gtggtcgcct tgtcctccac
     6301 cccggacagg tcgtcgatgc cgacccccga ctcggtgagg acctcctcgg tacgcagcgg
     6361 tcgggtctcg ctcaccgcgc cgaccatggt cgtcttgccc acgccgaaac cacccgcgat
     6421 caagatcttg atcgcagtgg gcaccgtctc cgccggctgc tcagagtgcc cgtagtccat
     6481 tgataaccgc ctcgaaaatg ctgtcgtcgg gaaggccgcc ggtggcccgc ggctcacgga
     6541 cctgcaccag attgcgggcc accaggtcac ccaggagcac ccggatggtg cccaccggca
     6601 ggtcgagatg cgccgctatc tccgcgacgg actgcatccg ttgacagagc cccacgatcg
     6661 cgaggtgctc cggcccgaga cccgcctccg gcgtgacatc cgactggatc gccgtcacga
     6721 gggagatcag gtcgaacgtg ccggtgaccg gtcgggcccg tccgcgagtc accgcgtacg
     6781 ggcgcaccac cggtcccgca tggtcgtcca cccactgctc ttccatcggc cccccggtaa
     6841 cggtcatgac gggctacttc tcggcggtgg ccgactgctc ggacaatcgg gacggcgagg
     6901 cgacgtactt gccgacccgg gtcaccagca tcgccatctc gtacgcgatc agccccacgt
     6961 cggcgtcctc cgaggcgagc acggcgagac aggcgttacg accggccgcc gtgacgaaca
     7021 ggaacgacga ctgcatctcg atgatggtct gctgcacctg cccgccaccg aaccgcttgc
     7081 ccgccccccg ggccaggctc tggatgccgg ccgccatcgc cgccaggtgc tcgccgtcgt
     7141 cccggctcag cccccgggac gaggccatca gcaggccgtc cgtggagaga gcgatagcgt
     7201 gttcggcctg cttcacccgg ccgaccagat catccaacaa ccacgtcagg tcggcactcg
     7261 aagccgtctt ctgcgccact cgtcgtcctc ttctcaaccc ggctggtcgc cgtgctcgtc
     7321 tgggctcact ccagggccgg tggacgggat cgcccgccac cgcgccccgc tcacgtcgct
     7381 tgccggtcct cgtcgtccgg cgcgtccgcc ggctccggac cgcgggccgg accacccagc
     7441 agccgggccg cgtcggtacg gccgcgccgg gtaccggtct ggtacgaact catcatccgc
     7501 cggacctgct cgggcggacg aaccgcctcg tcgtcctccg gggtgtccac gacgggcgtc
     7561 tcgtcccgca actcgggcgc gaggttcgcc tggcggaccc gcatcggcag accggactcc
     7621 gtgcggggcg gttccgccgc cggacacggg gtcgggccac cgtgctccac cttccgcgcg
     7681 ggttcggtac gcggggtggc caccggcagg ccggtcggga aggtgggacc gtccagcgcg
     7741 gactgctccg accagagtcg ggagcgggtc ggcaggccgg tcccgctctc ggccggcgtg
     7801 tcctgcggtg cccgagggcg ctccagcgtc gtccgtaccc gggtggggag ctggtcgggc
     7861 tcgtcgccgg tgccctcggg cacccggcgc ggcgaccccg gctcggccag cgccaccggc
     7921 agggccggac gcggaccgga cggctcggtg ccgatcaggg cgggcccgac cggcggctcg
     7981 acggcaccgg cgtggggggt gcccggcgca ccgggctcct cctcgtcggc ggtgaccagc
     8041 gccagcggaa tcagcacgac cgccgtggtg ccaccgtacg gggactcctt caggtgcacc
     8101 cggatcccgt gccgttcggt cagccggctg accacgtaga ggccgagccg ggtggcgttg
     8161 gcgaggttca gctccgactg gtcgacgatg cgctcgttgg cggcggccag gtcctcctcg
     8221 ctcatgccca ggccccggtc ctcgatctcg agggcgaaac cgttggccac caactgcccg
     8281 cgcacctcca ccgtggtgtg cggcggcgag aacgagagcc cgttctcgat cagctcggcg
     8341 aggaggtgga tgatgtcacc caccgcacga ccggccagcg agacctgccc cagcggcagc
     8401 acgttgaccc gcgtgtagtc ctccacctcg gcgaccgcgc cccggaccac gtcgaccatc
     8461 gggacgttgc gtcgccacgc ccggcccggg gtggagccgg agaggacgat gaggttctcc
     8521 gcgttgcgcc gcatccgggt ggccaggtgg tcgacccgga acaggtcctc cagctcctcg
     8581 gcgtcgttct cccgccgctc catcgcgtcg agcagggtga gctgccggtg gaccagggcc
     8641 tgggtccgcc gggccaggct gaggaagacg tcgcggacgt tgcgccgcaa ctcggcctgc
     8701 tcgacggcgg tccggatcgc ggtctcctgc acgacgttga aggcctggcc cacctgcccg
     8761 atctcgtcgt cgccgaactc cagcggaggc gcctcggcgg ccacgtcgac ctcctcgccc
     8821 cggccgagcc gctcgaccac gttcggcagc cgctcccggg cgagctggaa cgcggcctcc
     8881 cgcaggcgct ccagctgccg cagcagcgcc cgggcggtgg tgatcgagac gatgatcgag
     8941 gcgacgacgg cgagcagacc cagaccggtg gccagcacca gccgggtgat gaccccgacg
     9001 gccaccggcg tggcccggtc caccacatcg tcgccgccgg cacccacgac gtcgttgagc
     9061 tgctgcaacg ccgggtcgac cgcgctccgc caggcgtcca gctcgaccgg ggggcgcgac
     9121 tcggtgttgc gggcctggat gacccggtcc tccagggtgc gcaggcgctg gtgcgcctcc
     9181 ccctgggaca tctgctggta tcggttgcgg tccgccacgg gcagggcgct gatggtgctg
     9241 gctgcgatgt accgctgagc accgaccagc tgcgcgaact gcgcctgctc ggcggacgtg
     9301 acccgaccgg cggcgagggc gccgtgcagc agcgcgtcct cctgggacag cagttcccgg
     9361 gcgcggttga gctcgatcag ggcggcggtg tcgtgggcga cctgctggtc gtcgagacca
     9421 cccagctcgt cgtagagccg gaacatcgcg tcgaccacct ccacatagga ggtcagggcc
     9481 gttgcccggt cgatgctctt gtcgtcgatc gccgtccggg tccgggagag ttcgtccagg
     9541 ccggtgagca cgttgtccac cgcccgctcg acctcggtgc tcgccgggat ctcggtacgc
     9601 cagttcaccg cggacgcctc gaacgcgcgg gccagttcgt cggtgcggtc ccgctccgcg
     9661 cgcaacgcct ccagctgccc ggcctccggc cgtcccaggt acgccaggga gagacgacgt
     9721 tccttctgca actgcagcag cagcggttcg ctgggcgcga agacccgggc gttgagggtc
     9781 tggaccccga gcaggttgaa gccgtccccg acggtcaccc acgccgcgaa ggcccagagc
     9841 gcgacgagcg acgcgagcag tgcgacgact ttcgtacgga gattcgtact gcgggaaccc
     9901 attacaccgt cctggccggg tattcgattg acgtgcccga gcgtgggcgg tcgacgcacc
     9961 gatcgacccc ggcgcacgct agcagcgtcg ggaggttcac tcaagcgatc ctgatcatgg
    10021 cgctacggga agacgggccc gcctcgaccg gatccggacc ggccgacgtg cgtccccacc
    10081 aggtcaccgc gagcgccgcc gcgcggacga tcagtgacgg acgatacaga tccttgtcgt
    10141 gccagagcgc cggtccaccg tcgaaaccgt ccatcgtgac cagccaccgc cagccccgtg
    10201 cgatcgcctg ggcacactgg tcggacgagg cctgcccggc ggcgagcagc acctggaggg
    10261 cgtacgaggt ctcctcggcc gtaccgcccc accgccccca ggaaccgtcg gggtgctgac
    10321 cggcgagcac ccagcacacc gcccgccgca ccaccggttc caccgacgcg ccgacgccgt
    10381 acccgtgcag ggcgagcacc gcgcaactcg tggcgtagta cggcgacgcg tgccagcggt
    10441 cggaactcca cgagccttcc ggtgcctgcc gttcggcgag ccaggtggtc agccggcgca
    10501 ccaccggggc gaggtgttcc gcccgcgcac cgccgtgccg caggtgccag ccgacggcgt
    10561 ccagcacgtg cgcgttggtg gtgatggagg cgccgtcctc cttcggccag gtgcagaagt
    10621 gctccccggt gtcgaaggac cggagactcg acgggtcgac cggctgaccc gcgcgggcga
    10681 gcgcgtagag ggtcaccgag gtggtgtcgg cgtccaccgg cagaccgggg gcggtggccg
    10741 tgccggccgg gccgagcgtg tcccgcaggc tggccagcac cggcggcggg gcactcagcg
    10801 gcaccccggc cctcgacagc gtgctgagca cccacgaccg ttcgaagacg ctgatcgggc
    10861 tggtgcacgg gaccggcccg ccgtgctggc ggacgacccc ctccaggtat gcccgcgcgg
    10921 ccgaggtggt ggcgtcgggg acgccgagcc aggcggccgt cgccgcaggt gaggcgccga
    10981 ccgtccccgg cccgaccggg acgaccccgg ccgcccggcg cgccgccgga ccggcgacct
    11041 ccagcgcgtg catcagcttc tccggcagcg gatggcccga cgtcagagcc gcgcggaccc
    11101 gggccaaccg ggtgggcgtc atacccggcg gcaacggcaa ccggggcgcg gtccgccacc
    11161 gctccaatcc ggtcaccggg tcgtcccgca tcgcgtccag gtggacggtg agcgcctcca
    11221 ccagggccgg tacgatcagg tcgatggccg gcatgtccgg cagggccgac gcgggaacgg
    11281 cggcgagccg gtcaccgagg acggccagtc cccggtccac cgcggcgacc gcgccccggt
    11341 ggagcgggtc cgacgtcccg gccaggtcac ctcggcgcag cgcggcgagc agtccctcag
    11401 tggcgctgag cgtcggtgcc agaccgtagc cgccggggcc tccccagccg ccggtcgggt
    11461 gttccgcgtc gagcaggtag cggatccgcg cggcgtgcag cgtcaaccac ggcgacaggc
    11521 tgaccaggcg cccggtctcg tacaccgaca ccgaggactg tcccgtcggg gtcgccgtca
    11581 tctcgccgag caggtccccg acggcggcga ggatgctcac cgagcctccc ctccgttcgc
    11641 gactgcgggg ctccgctccg ctgcactcct cgcgctcacc gagcccccca gaagtccgtg
    11701 gaacggtaga agccgctggt gaagccgacc tgccgggcga ggtacgtcgc ctgccggggg
    11761 cactcctccg ccaggggggc cagcagctcg tggcagcgtc cggtgaggac ctcgacccgc
    11821 tgctcgacct ccgcccggtc ggccaccagc atgatcgcgt tgaggtcgcc ccactccagg
    11881 tcccgctggt acgtaccgag gtcgttgacc agccgcagca cccgctgcac ctcgtcgctg
    11941 gcctcgacca gccgggacag cgaacggtgg gtcccgtcgt cgccggtgtg gatccagtgc
    12001 gcgacgttga ccaccgtgca cgccaggttg tcggcgttgg cgaggtactc ctcgaaggtc
    12061 ggcagcgtgc cggtgaggtc ccgccgggcc gcccgccact cccactcgac cgccatcgcg
    12121 gccagcgtcc ggtgcaccgc ggcccgccac gcgtcacgca ggcgcgggta cgccggcgcg
    12181 gcggccaggt cggcgcagag ttcggcgaag aaccgggcga acgggtcgtc cgacgccggg
    12241 gtggcaccgt cgaccaccgc gaggctggtc tcggtcagac ggtcgatctc cgtccgggac
    12301 ttcgccaggt agtccacctg ccagtcgagg gcgaaccccc acagcacggc acggttggtg
    12361 acccgcagtt cctccagggt gcaccagggt gcgctgaacg ccatggccat ggcgatgttg
    12421 ccgaacaggg cggcgtcgaa gggcgcaccg gagaacagct ccgggtaccc ggccgcgagc
    12481 ttctgcaggt cgcgctgccc ccgggcggcg agggcacaga tccggccctg ctcgacggcc
    12541 tccgcggcct gggtgttgag gtccattccg tccgctccgc tcaggcggcg gccgagggcg
    12601 ccgcgccggt gagggtcagt tccacccggc ggcggggacg cagcgcggcc gccagccgca
    12661 gcccgggcac cccgggctgc gcgagccgga accggtaccg gctcagcatc gtggcgacga
    12721 tgagctgcgc ctccaggtag aacaggtaca tgccgaggca ctggtgcggg ccaccgccga
    12781 aggggaagtg ggcgtagcgg tgccgggccc ggacgcgctc ggggcggaac cgctccgggt
    12841 cgaactcgtc gggccggtcc cagaacgccg acatccgttg ggtgatcagc gggctcgcca
    12901 ccaccgtcgc gccggcctcg atccgcacgc cgccgaccac gtcggcggcg accgcgcggc
    12961 ggggaatcag ccacccgatc gggtacaggc gcagcagttc gtcgaggacc atccgggtgt
    13021 agcgcagttc gccgaggtgc tcgcggcgga ccggttcgtc gcccaccacc cggttgatct
    13081 cctcgtagag ctggtcggcg acctcggggt gctcgtccag gtgcggccag agccaggtca
    13141 acacgttgat ggtggtttcc gtggtggccg cgaacatcgc caccgtgtcg ttgcggacct
    13201 gccgctcgtc gagctgccgg ccgtcgtcgg tacgcgcccg ccacagggtg gagatgatgt
    13261 cgtcgccctc ctccgccgtg gcccgggatt cccgcacgat gggcacgagg acgtcgtcga
    13321 cgacccggac ggcccggcgg aaggtccggt cgccgggcat gggcagcgac agcggtgcga
    13381 agggcaccac gatccggggg atcaccgcgc tggcgatggc gtcctgcgcg tcgacgaccc
    13441 gcatcgcgtc ggccaccgag atcttgtcgg cgaagagcac cttcatgatc gcccggcaga
    13501 cgatccgggc ctgctcggca ccgatgtcga ccggtcgtcc gacgcgggac ggggtgccca
    13561 gctcgtcgac ggcgtcggag atcgcctcgg ccatcccgtc gatcatcgac tcgacccgct
    13621 tggcggtgaa catcggctgg agcatccggc ggctggccga ccagatctgc ccctcgccga
    13681 ggatcccctc gccgaagagc cgcttgaccg gtcgccagaa cagcccgtca ccggcccgct
    13741 cgtagttctc cgcccgttcc cgcagcacgt gttgcacgtg ttcgggatgg gtgaccagat
    13801 aggggcggaa cgagccgagg ttgatgcggg cgaggttgcc cccggtccgg ttacccgcgt
    13861 cgatgagcgc gcgggccgga tcgcggacca gggcgggcag catccggcgc agggggaccc
    13921 tcgtgggacg actgacatgc gccggggagg ggtgcggtgt tcccaccttc tgggctcctc
    13981 ccggtatcac cactgagtcg cggaaccgtc attccgagtc acaggacccg ctgagcatgc
    14041 catcacgatg tccggttcac cagagcgggg gcgagaaatt ttcgttgaca acaattgcgc
    14101 cgtccataaa ggacaattgc gcaggtcgtc agcggaacag cgtccgccgg taccgccact
    14161 cggcggccac cgggacgtac ccgagccggc gattgatcgc cagcatcgcc tcgtttcccg
    14221 catcattgct ggtcagagcg gtcgcgaagc ccgcctcggc agcccggtgc agcgcggcgc
    14281 gcttcaccgc gcccgccagc ccgcgccctc ggtacgcccg ccgcgtcccg gtcatccccg
    14341 actggaaacg gattgagcca tcagtcagcg cgaagctgaa cgccgccacc accccgtcgc
    14401 agatcgccac ggtcgtcagt gtccggtcca ggtccggacg gtcccagtag gtggtccgcc
    14461 agtcggcgta gccggtcgcg tccatgccca cgtcacccgg ctcgtcccgc gaggcgtcca
    14521 ggtcggcctc gtacaacgga cgtgggtccc cggccagcgt ggccgcgctg gcgatccgca
    14581 ccccgggcag ggccggcggc gccggcagcg cccccgtggc caggtccagc cgcaggtggg
    14641 tggtggcccg cccgcgccgg tagccgtgcc gctcggcgaa gcccaccgcc gccgggtcgt
    14701 cggtcacctt ggcgtacgcc acccgcacgc cgatcgcccg cagccgttcc tcggcggcgg
    14761 cgagcagggc cgaacccact cccctgcccc gccgctgcgg cagcacgttc aggttggcgt
    14821 aaccgagtcc cggctcggcg ctctcgtgca gcagtccggt ccgggcgacc ccgaccacct
    14881 cgccgtcgac ctcggcgagc agcatccggt gccgcgccgc cggcgccccg tgggccgcct
    14941 gccagcgcag cgccaccgcg ctgaacaccc agtacggcgc ggcgacccgg agcaccgcgg
    15001 ccacgtcggt ggcgtcctcg ggccggaatc ggcggatggt gacggtcatc ggctggcaac
    15061 ctacccgaac cgtcgccgac gcgtgggaag ccgggcgcgg cccggcggcc tgtgccaggc
    15121 tcgacacatg gacgacaaga ccatcctgaa ccgcatcgcc gagctggtcg acgaggagca
    15181 ccggctccgg gcggacgcgc agtccgcgca ggccggcacc gacgacgacg cccgcgcgcg
    15241 gctgcgcgaa ctggaggagg gactggacca gtgctgggac ctgctccgtc gccgccgggc
    15301 ggcccggcag acccacaacg acccggagag ccagggcgtc cggcccgtgc cggaggtcga
    15361 acgttacctc cagtgacccg gtgcgggccg gccccgcccg gtcggtgggg ccggcccgtg
    15421 caccggtcag cgcagtccgg cagcacgtgg cgactgcccg gtcagcgcag tccggcctcc
    15481 cgcaacaact gcccggtcag cgcggccgga tcggtcagct cggccgggag tccccgggcg
    15541 gcgaaccagg tgctcacgac gcggacgtcc cgggccagga actccgcccc ctgcggattc
    15601 gccaccacgt cgacggcctg cggcaggtcg atgaggacca gccggccgtc gtgcaccagg
    15661 aggttgtacg gcgacaggtc gccgtgggcg tgaccggtgc gggccagcac gaccagcacg
    15721 tccaccagct gctcccagag cccgcgcagc tcgtccggct cgggccgcag ctgggcgagc
    15781 cggggggcgg cctgcccctc gtcgacgtcg ccgatgaact ccagcatcag ctcggtgccg
    15841 atcagttgca ccgggtacgg cacggcgacc gtacccaggg agaccccgat ctcccagagc
    15901 cgggagagca cggcgaactc ggccgccgcc cactgcccgg cgatcatctg ccgcccgaag
    15961 ctggtacggc cggccatcgc cctggtctcc cgcgaacgcc gcacccggcg gccctccagg
    16021 taaccggcgt cccggtggaa gaggcggtgc tccggagccc ggtaacgctt gaccgccagc
    16081 aggcaggagc ggtcggtgtc gggcaccgca cgccggacga ggtggacgtc cgcctccttg
    16141 cccgtcttga gcaccccgag ttcggtgtcc tgggcggcga gttcggtgac cacccagtcc
    16201 gggtacggct cggggccgtg gatcgcctgg tcccaggtcg accagcggtc accgaccagc
    16261 ggatggtcgg ggtccccgtc gtcggagacg gatgccggcc ggggttgccg gccgtgcttc
    16321 aggaacggtg tctcgtcgtc gtcgaagcgg cgtttgccgc gcggtcggcg ctcgcgcgcc
    16381 gacgggtcga tgtcgtgttc acgcactggg tcggtgatcc cttgatcgag gctgattgag
    16441 gcaggtggat ggaccctgcg aagacggcca tgaccgaccc cctctcctcg accgggcgac
    16501 gcccggagtg cgctctgcgc ggaccatgct cgccaccgtg cgtccggatg gcaaccgatt
    16561 taccgccgcc gggttgcggg cggttcgacg gtcgtgggct cagccggtga cccggttccg
    16621 ctcgggtccc tggtcgggca accggtcggc cagcatcgga tggtcggcgc gggtccgggc
    16681 cagttgctcc ggatcgagcg tcgcgaccag cacggcctcc ccggtgtccg cgccgcgcac
    16741 caggcaccgc ccctccgggt cgtagaccgc cgcgccgccg ttgaaccgcc aggggtcgac
    16801 gccgtcgacg gagttggcga acacgacgta catggtgttg tccagcgccc gggccgcgta
    16861 gtagacgtcc cgtcggtgcg cggacccgac cacgtagccg ctcgggcaga ggtagccgtg
    16921 cgccccgtcg tctgccgcgg cgcgaccgtg ctcggggaag cagccgtcgt agcagatgcc
    16981 gaggccgaac cgccagtcgt cgaccgtcag cgtcgcccca cgccggcccg gggtgaacag
    17041 cttccgttcc tcgctccaga gctgctgctt gtcgtagccg acgcggaccg tcccggcccg
    17101 gtcgacgacc agggcggaga tggtccgtcg ctggtccggg tgccggaccg ccgcgctcag
    17161 gaccaccacc gtgcccgtct cccgggccac cgcgcgcacc gggtcgagcc ggggatcggc
    17221 gaccagggcg tccggcccgg ccgcgacgtc ggtgccggcc gggtcggccc cgaggaccgg
    17281 cggatggtac gccgacagga acagctcggg caggaccacg agccgggcgg cggagtcgac
    17341 cgcccgacgc accagccggg cggcgctcga cgcgttgccg gccacgtcac ccggcacggg
    17401 gtcggcctgg acggcggcca cggtcaacgt ggcggagggc agggacgtca tcccgcgatc
    17461 gtaggcggcg ctccggcggc cggacagagt ctcaagccgt acgtacggtt tgcatcgggg
    17521 cggggcacct ggaacgatcg ggacgtgccc agagtaagcc aggaccagct cgacgcgcgc
    17581 cgccaggaga tcctcgccgc cgcgcgggcc tgcttcgccc ggcacggcta cgagggagcc
    17641 accgtccgcc ggctggagga ggctaccggt ctctcccggg gggcgatctt ccaccacttc
    17701 cgggacaagg actccctctt cctcgccgtc gccgaggacg acgcggcggc gatggtggag
    17761 accgtggccc gcaacggcct ggtgcaggtc atgcgggacc tgctcgcccg cgcgatgtcc
    17821 ccggacaccg ccggctggct cggcagccag ctggaggtct cccgccggct gcggaccgac
    17881 ccgtccttcg cccgccgctg ggccgagcgc tcagccgcga tcgccgaggc gacccgggag
    17941 cggctggccc gccagcgcga ggccggcgtg ctccgcgagg acgtgtcgat cgacgtactc
    18001 gcccgcttcc tcgaactggc ctacgacggc ctggtgctgc acctggcgat ggggcgcccc
    18061 gccggtgacc tcggtccggt gctcgacctg gtcgaggagg cggtgcgccg ccgctgaccg
    18121 gctccggcgc gctccgccgc tccccggcga cccaccccgg cgcgcccgtc gcgacccgag
    18181 cgtcgggatc gccggatcgg cgcatgacgg cagctcaccg gccgttccct cgctggcggg
    18241 cctactccac aatggggccg ccacccctcg cggacaggag cagagacgat gaccctactg
    18301 gcggcaccgg gcgacacctg gggtatctcc ggccccacct tcctcgccgg ctacctcctg
    18361 gtcgccgcgc tggtggtgct cggctcgacc ctccaccgcg cctggctctt cgacggtcgc
    18421 cggccgcccg gctacgacca cctcggcccg gagcaggcgg catacctcaa cggcggcgcg
    18481 cggctggccg tctacagctc catcggcgcc ctgcgcagcg tcggggcggt cggggcggac
    18541 cggcgcaaac tgctacgggc caccggtccg ctgcccgccg gtgccaccgc gctggaccag
    18601 gcggtgcacc acgcggccgg gcggggcgtc cgcaccggcg acctgccgca ggaccactgg
    18661 gtggccaccg cgctcggcca actgcgccag gacctggaga accgggggct ggccctcgac
    18721 gccgaccggc gtcgtgccgc ccggttcggt ccggcgctgc tgttcctgct gctcctcgtt
    18781 ggcgtcctgc gcctgttcgc cgggatccgg aacgaccagc cggtgggctt cctcgtcgcc
    18841 gccatggtcg tgctcgcggt gatcttcgtg gtgcaggccg cccgggtgcc gtaccggacc
    18901 cgcgccggtc ggaccgccct gagcaacctg cgggcccact accggtacct gacgccctcc
    18961 gcctcgcccg cgtacgccac ctacggcgcg gccggggcgg cgatgggcgt ggcgctgttc
    19021 ggcgcagcca cgctctgggc gttcgacccc gacttcgccg acgccgccgc gatccagcgg
    19081 caggccgccg gcagcggcac cagcgccggg ggcggggaca gcggtggcgg ggacagcggg
    19141 ggcagcagct gcggtggtgg gagcagttgc ggtggcggtg gcgggtgcgg cggcgggtgc
    19201 gggggatgac cacgccgccc cgcacgaccg ggtccgtcgg cgcgagccgg gcaggaccgc
    19261 cggcgggtgt cggcatcggg tggcggccgg agatcgccgg cttcgtcgcc gacctgcccg
    19321 gcctgcgctt cgtcgaggtg atcgcggagg gtgtcgcccc ggccgggcca ccgccggccg
    19381 ggctcgccga gttgcgggcg gccggcgtca ccgtcgtacc gcacggggtg cggctctccc
    19441 tcggcggcgc ggacccggtc gagccgaccc gggtggccca cctggccgcg gtcgccgacc
    19501 tgctcgacgc cccgctggtc agcgagcaca tcgccttcgt ccgggccggc ggggtggagg
    19561 ccggtcacct gctaccgctg ccgcgcaccc gggaggcggt cgaggcggtg gcggccaacg
    19621 tccggcgggc acaggcggac ctgccggtgc cgatcgcgct ggagccgatc gccgccctgt
    19681 tcgactggcc cgacgacgaa ctggacgagg gggcgttcgt caccgagatc ctcgaacgca
    19741 ccgacgccct gctgctgctc gacatcgcca acgtgtacgc caacgcccgc aaccggggca
    19801 ccgacccggt cgcgctgctc gaccggctcc cgctcgaacg gatcgcgtac gtgcacgtcg
    19861 ccgggggcgc cgagcatgac gggctctacc acgacacgca caccgacccg gtaccgccgg
    19921 aggtcctcga cctggtcggc gcgctctgcg cccggcaccg cccgcccgcg ctgctgctcg
    19981 aacgggacgg gcggtatccc ccggcggcgg cgctgcgcgc cgagttggac gcgctcgcca
    20041 ccgccgccgg ctggccggtg atcacgtgag cggcagcctg gccgaccggc aggccgcgtt
    20101 ggtcgcggcg ctggtcgccg gggccgacgc gccgcccggc ttcgacaccc accggctcga
    20161 cgcggcgcgg acggcgctcc tgcgcaagcg ggccggggag gtcggccggc actggccact
    20221 gctcgccgcc ggcctcggtc gcgcctggcc ggcgacgttc ctcgggtggg cggcggggcg
    20281 ccccacccgg ggcggcctgc gcgacggctg ggacctcgcc cggacgctgc gggccgacgg
    20341 cacgctgccg ccgatggccg ccggggaact cgccgtccgc gaggccacca gccactacga
    20401 cggggagcgg ccaccccgcc tccgtcggct gccggccgtc gtccgggtcg gcgacgccgt
    20461 cgcggtgcag ctcgccggtc gggtacgcct gcacggcacc cggcaccccg gttgaaccgt
    20521 caggttccgg cgaggcgtcg tcacgccccc tgtcgtggct cagccgatcg ccagatcgcg
    20581 tgaaactgct ccagccagta gtcgtaccag gggtcgtccc gcccgcgtac cagtcgcagg
    20641 tgcatccggg aggtgatcgt gtcactgcgg aagccgtgga actccacgac gacgaagccg
    20701 tccctgccgg acgggtcgac ggcaacgatg ctgaagccgg gactaaacgg gagggtccgg
    20761 tacccgaagg cgccgggcac ctgccagcgc gccatgctgg cgagtcgctg atgcgtctcg
    20821 cgcaaggagt cggccacctg ctggaccggg atctcgagca gaaggtcgag ctgtcgtacg
    20881 acggcggaga cgtcctcggt ctccgattgt cccagcacca ccacccgcac cgacccgtcc
    20941 cgtctcgcga gcggcccggt acgcaggagc tcgcaccgtt cccggttgag gaagttctcg
    21001 gccgtcggcg cgaagacgag aacctccctg gccccacgca gcctctcgtt gaccggatcc
    21061 gtcaggaacg ccgaacggtc cagcagtacc cgatcgctcg agccggctgt ccaggtggcc
    21121 gctgccgtcc gcagcaccaa caggcccagc gcgccgaaga gcaccgacca gcgcacatcg
    21181 tccgggagat cagcacccac catcgtcagt gccgcgacga ccagggtcac cagcgccacg
    21241 gtgtagagat cgaggttccg ccagtgccgc acgtcggcca gaagccggcc gaacatggcc
    21301 cgcataactt ccccctcggt gtcccgtcga agcggtcagc gtcacgccga gccgcccggt
    21361 caacgcacca gatcctcagt cggcgtcgtc ctcggacgtc tggcggtccg agagtcgagg
    21421 gccggtcgtc atgtcgggca tccggcccac gaagggagga ggagagaccg gtcggtcgga
    21481 gaccaccaca tggctctccg cgtcgatgac gctgacccgc agatcgctga ggcgttcgat
    21541 gacctctgcc ggatcgatgc cggcaccgcg cacgacgacg agacgggcga tcagggagag
    21601 gatcacttca ggctgcacga accgcgcgac cgtgggtctc ctggccagag cgttcaggcc
    21661 ggacggccgc agacgggagc gcagcaccac cagggcgtcc cggttcgcga agaagtcgac
    21721 ctcctcctgg cccagctcgc ccgccgggac cgcgacgacg atcgactcct ccccgacgct
    21781 ccagcgtgct tcgtagtgcg agtcgtcgat ccgcgtctgg acgtccacac ccagcccgga
    21841 gccgagaccg gcgaaaagct cgacgtacgc tgccgggtcc gccgcctgca actcctcacc
    21901 caggtcgtcg aaggtcatac tgtccgggcc gggcaccacg acgttcgccc attctctcga
    21961 caccatgtgt cggaactccg actcctcgcg ttcgcgacgc tccaaccgct cccgggcgac
    22021 ctcacgctgg gcttcgctga tggcgggatg gtcggcgata ccgggcaggt ccaggatcga
    22081 ggcccagccc tcgttcaccg gaggcacctc ccacagtttc gccagccggt tgcggtgcag
    22141 ggcgtccagg cggagcttgg cgatgggggc gagccaggcg ggcagaccga cctccgtctg
    22201 caacgcgagc agcatgaccc ggctggacca gtcgtgactg tcggagaagg agacgctggc
    22261 cgcgccacgg atcaccccgg ccacctgttc acacagttgc tctatgtcgc tgtagtgcag
    22321 gttgagctcg accggccgtt ccccgcgctg gggctcgtcg gaccggatgg ctgcggagaa
    22381 cctcgccttg atctgctcga acggaatccc acggctccac tcgaacgcca ccagcgcccg
    22441 tagcaacgcc gtggcgtccc ggtcctcgac ctcctcgacc ccgcgctcga aaagcccgcg
    22501 gagctccttg gagatcacgg cctgtccctc gctgacgaac tggcgaggga gggcgtaccg
    22561 tcgatcaccg aagtactggg cgcaatacga tctccgcgtg gcgtcctcgt ggcagtaggc
    22621 catcgcgtac gtctggatgt tctccttgag ggacggatag tggcgggggt ggacgccggg
    22681 cagccccacc cacgcggtga cgctctcgat ctcctcgctg cggcacgcgt tgaagagcag
    22741 gtcgatgtca ccggtgccct cggtcgcgag gcgcgccagg cgttcgagga tgtgggcgct
    22801 gtggagagag agcgcagagc gggcgagcgc gtcaccgagc cgggtgggct gctgtttggg
    22861 cgcgtccgca ctgccgatga gcttgaggcc ccggagcttc tccagcacct cggagaccga
    22921 aggcaaccgg gagtcgggct cctgggccgc gaggagggca ttgaggatcg aggccacccg
    22981 agcctcgaag tccgcgggcc gacggccgaa gccgtccgcg ctgagtacct gtagggcgag
    23041 cagggacacg tcctccagat cgcggatctg gccactgaca cgcggcgttc gctgacgccc
    23101 gatcacgtag tgggcgtaca caccgtcgag cgaggacaac gtacgaatct gggtggccgt
    23161 caactccgcg acgttttcca ggtcccgctg gctcggcacg agaacgtaga actcgcctct
    23221 gggccgttgc acgacgcctc gacggccggc ccggccggcc ttgttgtcca gctccgacgg
    23281 catgctcaga cgccgacgcc ggtcggaccc gtagccggag atgctcgtcg cgatcaccgc
    23341 gtcggcgggc aggttcacgc cgatggcgag ggtgtccgtc gccaccagca cccgcaggat
    23401 gccgcgcggg tcgcggaact cctgctcgag gtcgcggcgg agcttgggcg cgagccgggc
    23461 gctgtggtac gcgacgccgg tgcgaagccc tcggatcacg tcgtcggaga gcggaagatc
    23521 cgagttcttg atctccaaca tccgggactg tgccgtctgc tcgtcgatgt tgtcgggggc
    23581 gaaccgaccg acctgccagg gcgaaccgcg gtgccggcac ctgccaagcg cggcatcgag
    23641 gctgcgctgg atggctgagg ccaactcctg ggcggcggtc cgtcctggca cgaagacgag
    23701 gatccgtctc gccgggtcct cggtaagcag tcgggtgacc agtgcgatgg cgagtggcgc
    23761 ggtactcagt ccccgcacct gcagcatgcc gtagtcggcc cccctcgcgc gtgcgcccag
    23821 gtcgtgcgtc tggtcctcgg gcggccccac ggcctggtca ctctgctcga gattgagcag
    23881 gtgggcgtcc cgcaggatcc tccaccggtt ggcgtccacc acgtaggtgt cgagcgggac
    23941 cgggcgttcg ctgctctgga tgaaattgaa ggtgtcgacg cccaaccacc ttctcagcag
    24001 atccgtcgac tgctccgaca tggtcgcgga gaggccgagg atgcccggcc gctcgtcggg
    24061 gtgcatcagg cgcaccatgg tgagaagtcc ttcgagcttt gcggcccgtc gtttgtcctc
    24121 gaccagggtc tgtagttcgt ccaccaccag aagttgggtt cccgcgaggg tgcgttgacc
    24181 ggagacgaga tatccggcga gcttctcgta gatggcgatc gcgatctcga accgaccctt
    24241 cgacaccggc gagtcgtgtt cggggtagtc gcgggacgaa ccgtagacgc ggatcttccg
    24301 ctccgcttcc agccaggccg cgatccatgc ctcccactcg cgcacctcct gggtgacgag
    24361 ggccttggtc ggcaggatca ttatcgccga cctcgcacgg ttgaccgcca ggttcatcgc
    24421 cacccgcgcc accgtggtct tcccggagcc cgtcacggca ctgatcagcg acgtccctct
    24481 cgtgccgagg gcacgcaggg cagcagccaa catggcgttc tgcgcgtcgc cgcgctcgac
    24541 gcgtgccccg atctgccggg tcatgttctt ctgcacggac tcggggaggt cgagcccgtc
    24601 gtcactctcg ccgaccggct gcggcggaac cgtcgaccgc tcgtcttccg cgacgtccgg
    24661 atccgcgccg gcgtccaggc cgagaacgtc acgcaggaac cccggcaggt ctccgaactc
    24721 gtcaccgtac ggaaggtagg ccagcctgcc gaccagcttc ttcgccggca tctccgtcct
    24781 ccgtacgagc acgtaggccc ggcgcacggt cttctcgaac ttctggttga accagtcgag
    24841 gaaggcactg aagtgcggat cctcgagccc tgccccgtag ccgacgaaca cgagtgtgtg
    24901 attcgccgac agggcgcgga ggacctccgt ggcaagaccg gccgaggcaa gtcgttcgta
    24961 gtcgccaccg gagaggatca cggactgcgg ccggtcgtgg tgaccgtgca gatggaacac
    25021 gtaatcctgc ggagtgtcat ggtatcgatc gatgtcgtcg cgatccatc
//
