LOCUS       NZ_BNBR01000010        15843 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence10, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000010
VERSION     NZ_BNBR01000010.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 255716)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 15843
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15843
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     gene            <1..67
                     /locus_tag="IE308_RS37530"
     cand_cluster    1..15843
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15843
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[4589:5843](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4590..5843
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     CDS             <3..67
                     /EC_number="3.13.2.1"
                     /codon_start=2
                     /inference="COORDINATES: protein motif:HMM:NF017071.5"
                     /locus_tag="IE308_RS37530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosylhomocysteinase"
                     /protein_id="WP_190221139.1"
                     /transl_table=11
                     /translation="EQAAYIGVDVDGPYKPDHYRY"
     misc_feature    262..279
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.44"
                     /tool="antismash"
     gene            365..1573
                     /locus_tag="IE308_RS35160"
                     /old_locus_tag="GCM10018783_71120"
     CDS             365..1573
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="IE308_RS35160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71120"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_110627842.1"
                     /transl_table=11
                     /translation="MTEYIQNPVLWAVVVVLVAAIAVIVRQRKSAQALRHEIDGLRSHY
                     SDLENHYAQSVAAAQEQAEDATKTVLKSAMRTLQGLAAEQQLVVSRLQTKYGDSTILQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGRHRDAASVYDVVRSAQGRIRHYRRVEILSQVD
                     FGITSRAVEPVALALAELLDNATSYSSPDSVVEINIRTVPKGICIVVDDAGVGMNDEER
                     ARAEKLLSSERVSGVSGLGNPPQFGFAVIGVLAERFGFEVSVDSSSPYGGVRAVVLLPH
                     DLLTAMPEQKVQAPAVSAAAVPHPAGPEPSLTAATTADGLPRRRRKRPMAIVPGSAGGA
                     GGTGGGTAGRGSGSRSGAETAAIMGAFQRGTQSGRAAHDDRAGRTDQTSGTTGASSEGH
                     EVS"
     gene            1570..1971
                     /locus_tag="IE308_RS35165"
                     /old_locus_tag="GCM10018783_71130"
     CDS             1570..1971
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="IE308_RS35165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71130"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_110627841.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTKDFDKDNADRV
                     AAAMSGVQSLSRSLGFFCEDPRQAWRQTLVEFDGGWVFLISAGEGAYLGVSASPDVDMQ
                     DITFRMQQLVGQLGKALAAPPRENLGARS"
     gene            1968..2345
                     /locus_tag="IE308_RS35170"
                     /old_locus_tag="GCM10018783_71140"
     CDS             1968..2345
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="IE308_RS35170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71140"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_110627840.1"
                     /transl_table=11
                     /translation="MTGPGEWEPEAAELVRPYVITKGRGLPDEAELSLITLVTAAPEGP
                     RRPTRLSPEEQRLLDICSAGYLSVAEIAGHTRLPLGVVKILLAALTEGGYLITRPPVAR
                     APLADREILEEVLNGLRAKFG"
     misc_feature    2007..2009
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2320..3033
                     /locus_tag="IE308_RS35175"
                     /old_locus_tag="GCM10018783_71150"
     CDS             2320..3033
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005331.1"
                     /locus_tag="IE308_RS35175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71150"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_229909367.1"
                     /transl_table=11
                     /translation="MAFAPNSVEPPHAVEPPHAVEPPHAVEPDTAGDPPAPHAGPGTSP
                     RLGAQAYVRGGATQTAVKILVVGHFAVGKTTFIGTISEIEPLSTEETMTRAGEEIDDLK
                     GVTGKTTTTVAMDFGRLTISDRVVLYLFGTPGQQRFVQMWEDMARGALGALVLVDPERL
                     ADSFQVIDLIEQYSLDYAIAVNHFDGAPLRDEAALREALDLLDDTPVVTCDARDEKSSA
                     AALTTLVRYLLDRVR"
     gene            3116..4468
                     /locus_tag="IE308_RS35180"
                     /old_locus_tag="GCM10018783_71160"
     CDS             3116..4468
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388030.1"
                     /locus_tag="IE308_RS35180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71160"
                     /product="cytochrome P450"
                     /protein_id="WP_190220996.1"
                     /transl_table=11
                     /translation="MDAHTPAPVPPPGCPAHGSGGRVPLYGPEFAADPQAYYAFMRHYG
                     PTAPVEIAPGVEATLVTDYQAALQLLQDSGTFRKDARRWRDFNEGRIPADSPVAPVLAY
                     RPNCMFADGAEHLRLRQAVTDSMARVDSRRLSHTAEQVSDYLIEQFAARGSADLLGDYA
                     KQLPLFVFNELFGCPADIGDRVLFGISGMFDGVNAEKAMGVMFGALGELVAQKRARPGE
                     DVTSWLMAHQARLTDEEMVHQLALLMVAGNEPLRNLIGNTLHRLLTHDAYAHRGGLIDE
                     ALDDTLWENPPMQNLAAHYPAADMEFAGTKLQAGDLVLVSFAAANTGPTLTAARQAGSN
                     RAHLAWSAGPHACPSKDPARQITVTAVENLLNRLPDVELAVPEDTLAWRPGPFNRGLTT
                     LPARFTPVESVRRAAPEPRPAAPAHPGPAPAAARKGERGGLWSQFLNWLIK"
     misc_feature    4476..4491
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.36"
                     /tool="antismash"
     misc_feature    complement(4487..4496)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.04"
                     /tool="antismash"
     gene            4590..5843
                     /locus_tag="IE308_RS35185"
                     /old_locus_tag="GCM10018783_71170"
     CDS             4590..5843
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388029.1"
                     /locus_tag="IE308_RS35185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71170"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_268256500.1"
                     /sec_met_domain="indole_PTase (E-value: 1.8e-137, bitscore:
                     451.9, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHISAYSTTRPHPWHPPIPAPAGGYLHAGPETSGIADHIGNPGT
                     LGSLTAGQLRRLCAVAGLGPAAADGYARTLVGALGPVADRPLDLPPVTPTFLSDDHTPV
                     EYSLSFTPGAAPALRVLLEPGCGAGSLARSGRAGLAAVREMARRWNFSTAVLDELEDLF
                     LPPAPEGPLALWCALELRPGGVPKVKVYLNPAARGAGRAAATVREALRRLGHRRAFDAL
                     PAADGHLFFALDLGDWDEPRLKVYLAHQDLTARAAGGLSRMDPGPGEAEIRAFFHLATG
                     TGTGPDLGAGTVGGTGAVRLDRRPGQSCHAFTETASGRPSGFTLYIPVRDYARDDEEAL
                     ARAEAVLDRYGMDPVPLLAAVPALTARRPADGVGLVAYLGLAHQQGRPPRVTVYLSAEA
                     YAVRPPAGTPTACPEPVS"
     gene            complement(5916..7205)
                     /locus_tag="IE308_RS35190"
                     /old_locus_tag="GCM10018783_71180"
     CDS             complement(5916..7205)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358093.1"
                     /locus_tag="IE308_RS35190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71180"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_190220997.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.7e-15, bitscore:
                     50.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FMO-like (E-value: 7e-83, bitscore: 272.6,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVCVIGAGLSGLAAAHALKARGVDVVCLEKAPDVGGIWRQPEAG
                     ERGPAYRALHLNSARQLTGYTDFPMPDSLPLYPRHSDVAAYLRSFAEWATLLDRIELRT
                     KVLTVRQQVDGSWTVVSRDAEGAQRTRSFEHVIVASGHNTRPALPDPLPPGADTSAGTI
                     LHSMDYQDGADFAGQRVVVVGLGASAVDIAADLSRHAARTLLSVRRGLHIIPKQLFGIP
                     VDLIADAPWFTAMSFPEQRAWVEKALLVARGRLSDYGLPEPDHPVFSSAVTISDEILSR
                     IRHGAVVPKPAIEAFDGGRVLFADGTAEEADAVVYCTGFRMSFPFLPAGCPAGDGGPVE
                     LYRRVVAPDRPGLYFLGLIRPHGSITRLVEAQARWVARLVAGEASLPSADVMRKEIAAY
                     LSGIEERYGRTEGTSIQVDVGAYLRELQDA"
     misc_feature    7223..7234
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.72"
                     /tool="antismash"
     gene            complement(7339..7746)
                     /locus_tag="IE308_RS35195"
                     /old_locus_tag="GCM10018783_71190"
     CDS             complement(7339..7746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660851.1"
                     /locus_tag="IE308_RS35195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71190"
                     /product="MazG-like family protein"
                     /protein_id="WP_229909369.1"
                     /transl_table=11
                     /translation="MSHDDTANATATTPAAADAAAGLWDTVDALWASLEARQPIGGREG
                     LLLAVLKLSEEVGETAQAVIGATGQNPRKGTTHSWDDVQAELCDVVFTALIALRTLTPD
                     ARKVFARHLDRVARRTLGPTAPPQPAPPEAS"
     gene            complement(7815..8372)
                     /locus_tag="IE308_RS35200"
                     /old_locus_tag="GCM10018783_71200"
     CDS             complement(7815..8372)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036887.1"
                     /locus_tag="IE308_RS35200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71200"
                     /product="DoxX family membrane protein"
                     /protein_id="WP_110627836.1"
                     /transl_table=11
                     /translation="MTLYDRRDLGLLLLRLGTGGVLAAHGAQKLFGWFGGHGIEGTGQF
                     MESVGYRPGKVSAMAAGLAEAGGGTLLALGLATPAAGAAAAGAMAGAASVHAPNGFFNQ
                     EGGYEYAASLGLTAAGLAVTGPGRLSLDHALGHTVDRGWMVPFAFAATGLATAVAVGLR
                     VQRVRRQKQGEQEALFEEDLAE"
     gene            <8533..8700
                     /locus_tag="IE308_RS35205"
                     /old_locus_tag="GCM10018783_71210"
                     /pseudo=""
     CDS             <8533..8700
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004988894.1"
                     /locus_tag="IE308_RS35205"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71210"
                     /product="nuclear transport factor 2 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="EIFTTRGHLEVDSESDGGRALPARYGNDAWGEMRTRRRFTVEDDG
                     RISRFETGQA"
     gene            complement(8953..9732)
                     /locus_tag="IE308_RS35210"
                     /old_locus_tag="GCM10018783_71220"
     CDS             complement(8953..9732)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (16-183). E-value: 8e-10. Score:
                     30.8. Matches aSDomain:
                     nrpspksdomains_IE308_RS35210_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358563.1"
                     /locus_tag="IE308_RS35210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71220"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_190220998.1"
                     /sec_met_domain="adh_short (E-value: 1.3e-33, bitscore:
                     110.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTERNPERPPRSRIAVVTGAGSGIGRAVAVELLRAGWSVALAGR
                     RTETLEETAALVPEGTCLVVRTDVARPEDVAALFAATVERFGRVDLLFNNAGTFGPGGV
                     PVEELSFDAWRHVVDTNLNGAFLCAQAAYRQMKEQDPQGGRIINNGSISAHTPRPHSAP
                     YTATKHALTGLTKSLALDGRPYRIAVGQIDIGNAATDMTARMQKGVLQANGEIAPEPVM
                     DVADVARTVRHMAELPLEANVQFATVLATTMPYVGRG"
     aSDomain        complement(9184..9684)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS35210_PKS_KR.1"
                     /evalue="8.00E-10"
                     /label="IE308_RS35210_PKS_KR.1"
                     /locus_tag="IE308_RS35210"
                     /protein_end="183"
                     /protein_start="16"
                     /score="30.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVTGAGSGIGRAVAVELLRAGWSVALAGRRTETLEETAALVPEGT
                     CLVVRTDVARPEDVAALFAATVERFGRVDLLFNNAGTFGPGGVPVEELSFDAWRHVVDT
                     NLNGAFLCAQAAYRQMKEQDPQGGRIINNGSISAHTPRPHSAPYTATKHALTGLTKSLA
                     LDGR"
     CDS_motif       complement(9598..9684)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS35210_0001"
                     /evalue="2.90E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE308_RS35210"
                     /protein_end="45"
                     /protein_start="16"
                     /score="7.1"
                     /tool="antismash"
                     /translation="VVTGAGSGIGRAVAVELLRAGWSVALAGR"
     gene            complement(9806..10858)
                     /locus_tag="IE308_RS35215"
                     /old_locus_tag="GCM10018783_71230"
     CDS             complement(9806..10858)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036904.1"
                     /locus_tag="IE308_RS35215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71230"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_190220999.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.1e-27, bitscore:
                     91.0, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 6.1e-28,
                     bitscore: 91.2, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADTVRWGVLATGGIAAAFTADLVDLPDAEVVAVASRSEASAKT
                     FADRFGIPRAYGDWASLAADDDVDVVYVATPHAAHRAAAGLLLEAGRNVLCEKPFTLNV
                     RQAEELVALAREHGSFLMEAMWMYCHPLVRRLKALVDDGAIGEVRTVQADFGLAGPFPP
                     AHRLRDPHQGGGALLDLGVYPVSFAQLLLGEPADVAARAVLSPEGVDLQTGALLSFDSG
                     ALASVHCSIVGGTGVTASVTGSHGRIDVPDGFFHPERFVLHRDGRDPEEFTADPADGPR
                     GTFRHEAREVMRALRAGETESPLVPLDGTLAVMRTLDAIRERVGVRYPGENPENPESPE
                     EDGAGALLSL"
     gene            10944..12293
                     /locus_tag="IE308_RS35220"
                     /old_locus_tag="GCM10018783_71240"
     CDS             10944..12293
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036906.1"
                     /locus_tag="IE308_RS35220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71240"
                     /product="multidrug effflux MFS transporter"
                     /protein_id="WP_190221000.1"
                     /transl_table=11
                     /translation="MPEGGAHRPQTTRRGRAEPAAGTRPAAPGPHRRTGLLVTLVLGGL
                     TATPPLAMDMYLPSLPEVTRTLQAPAATVQLTLTACLLGMALGQLVVGPMSDRWGRRRP
                     LLAGLAVYVLATALCAFAPTVGTLVAFRLAQGLAGAAGIVIARAVVRDLYDGVAMARFF
                     STLMLISGVAPVVAPLIGGQILRVTDWRGVFVVLTVVGALLGTLVWFRLPETLPPADRH
                     SGGVGEALHSMRRLLTDLPFTGYLLAGGFAFAALFAYISASPFVVQEIYGASPQTFSLL
                     FGLNSVGLVVVGQINGKVLVGRVRLDRVLGAGLAVVILAATALLLMATGAFGDVGLAPV
                     AAALFVLMSAMGVTLPNTQSLALLRTRHSAGSASALLGTSSFLIGAIASPLVGVAGEHT
                     AVPMAVVQLTAGVVALACFLGLCRPWRTGTDGGDRGAPGAVGAENAGAGH"
     gene            12290..13429
                     /locus_tag="IE308_RS35225"
                     /old_locus_tag="GCM10018783_71250"
     CDS             12290..13429
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326197.1"
                     /locus_tag="IE308_RS35225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71250"
                     /product="serine hydrolase"
                     /protein_id="WP_229909388.1"
                     /transl_table=11
                     /translation="MSAPRLRRDTPERAGLDPDELGHLVREVRDLTTGPRPWAAGAVVV
                     AGRGPVVAVHEAAGHAVRYAAYDPATDTGVELPPADRVPMTVDTPFDLASLTKLCTAVA
                     AVQQIERGTLGIDALVGAYLPEFRGAAGAGVTVRQLLTHTSGLRPELPLYDCADDAERL
                     ALLRAEAPSAPPGTYLYSDLNLLLLQHLLERLTGRPLDVLVHDGITRPLGMTATRFGPC
                     PGAAATEDQRRPWAKADRGMLRGEVHDENAWALGGVAGHAGLFSTAWDLAVFCRTLLAG
                     GSYGPARILGPDFVELLLTPPGLGFAVDQRWFMGDLAGRGAAGHTGFTGTSLVLDPATD
                     TFLVLLANTVHPRRRTPDSGPRAAAATRLARAVRGVGAA"
     gene            13537..14529
                     /locus_tag="IE308_RS35230"
                     /old_locus_tag="GCM10018783_71260"
     CDS             13537..14529
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067270.1"
                     /locus_tag="IE308_RS35230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71260"
                     /product="small ribosomal subunit Rsm22 family protein"
                     /protein_id="WP_190221001.1"
                     /transl_table=11
                     /translation="MNVPVSSSPADTLRTALSGLLDGLPPRQAAQAVERLIGHYRGATP
                     TDAPILRDRADVAAYAAYRMPATFEAVRSALAALAGAAPEWTPSGHVDVGGGTGAATWA
                     VTAVWDGTRPTTVLDWAEPALALGREIAAANPALRDARWQRSRIGTALTLAPTDLVTVS
                     YVLNELTAADRAALVDAAATAAQAVVIVEPGTPDGYTRVLEARDRLIAAGFQVAAPCPH
                     SAACPIAPGTDWCHFSARVSRSSLHRQVKGGSLPYEDEKFAYVAATRFPATPAPTRIIR
                     KPQIRKGQVLLDLCEPAERLDRVTVTKRHGDLYKAARDAEWGDGWPAAD"
     gene            14629..15048
                     /locus_tag="IE308_RS35235"
                     /old_locus_tag="GCM10018783_71270"
     CDS             14629..15048
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS35235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_71270"
                     /product="hypothetical protein"
                     /protein_id="WP_190221002.1"
                     /transl_table=11
                     /translation="MAPVGAAQVWVWVTAVAAGVVTVGLVLVMVLVDMDTAGQVATVTG
                     TVLSAAALLVSVLALAGGGGSGRTVRAGRDGIAVGGHVTGSALGRDAKVSGAATPPAAT
                     APAPDADVRSARGGVATGGDVTDGALGPGSRRDIT"
     gene            15095..15733
                     /locus_tag="IE308_RS35240"
                     /old_locus_tag="GCM10018783_71280"
     CDS             15095..15733
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522431.1"
                     /locus_tag="IE308_RS35240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_71280"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190221003.1"
                     /transl_table=11
                     /translation="MPDPQPRKQAPDATRRSQRSRQAIYDAALALVAEVGYPKTTVEGI
                     AARAGVGKQTIYRWWPSKADVLLEAFLDLSAQAAEQAGAQPGEPYALPDTGDLAADLKG
                     VLRATVDELLDPRFETPARALAAEGLVNEQVGREFVAKLLEPQLQLYVDRLRAAQDAGQ
                     VRPEVDPRIALELFVSPLAQRWLQHTGPISYDYTDTLVDYALYGLAPRV"
ORIGIN
        1 ggagcaggcc gcgtacatcg gtgtcgacgt cgacggcccg tacaagcccg accactaccg
       61 ctactgaccg gcccacccca cccgacgacg agagcaccac ggtctgacgg ccccggcccg
      121 ccggcactcc ccttgttgcc ctcgccgccc tcgctgcccc cgcaccggac aggttccggc
      181 gcgggggcct tttttgcgtg cccgccggcg gaagagttca ctcaactttt cgcccagcgc
      241 gcctcgttga cggtcggtca catgttcccc cagtgatacg atcaccgcac tcgcggcgcg
      301 ggcggacgca tgcgttcccg tggtggattc ccccagctgc cgtcagtcgc ctgaagagag
      361 tcttatgacg gaatacatac agaaccctgt gctctgggct gttgtcgtcg tcctcgtcgc
      421 cgccatcgcc gtcatcgtcc gccagcgcaa gtcggcgcag gccctgcggc acgagatcga
      481 cggactgcgc agtcactact ccgatctgga gaaccactac gcgcagtccg tcgcagcggc
      541 ccaggagcag gccgaggacg ccaccaagac cgtgctgaag tccgccatgc ggaccctgca
      601 gggcctcgcc gccgagcagc agctcgtcgt gtcgcggctg cagaccaagt acggcgactc
      661 gacgatcctc caggacctgc tggagatcga ccacacgaac tcgcagttcg ggcggcgggc
      721 gcagtccatc gccgtgctgt gcgacgggtg gctcgggcgg caccgggacg ccgcgtccgt
      781 gtacgacgtg gtcaggagcg cgcaggggcg gatccggcac taccggcgcg tggagatcct
      841 gtcgcaggtc gacttcggga tcaccagccg ggccgtcgaa cccgtcgcgc tcgccctcgc
      901 cgagctgctc gacaacgcca ccagctactc gagcccggac agcgttgtcg agatcaacat
      961 ccgtaccgtg cccaagggca tctgcattgt cgtcgacgac gccggcgtcg ggatgaacga
     1021 cgaggagcgg gcgcgggccg agaagttgct gtccagcgag cgggtgtccg gtgtgtcggg
     1081 cctcggcaac cccccgcagt tcgggttcgc cgtgatcggt gtgctcgccg agcggttcgg
     1141 cttcgaggtg tccgtcgact cgtcctcccc ctacggaggc gtgcgcgcgg tcgtcctgct
     1201 gccgcacgat ctgctcaccg ccatgcccga gcagaaggtg caggcccctg ccgtgtccgc
     1261 tgccgccgta ccccaccctg ccggacccga gccgtcgctc accgcggcca ccaccgccga
     1321 cgggctgccg cgccgccgcc gcaagcggcc gatggcgatc gtccccggaa gcgccggagg
     1381 cgcgggaggc accggaggcg gcaccgccgg gcgtggctcc ggctcccgct ccggggccga
     1441 gaccgccgcg atcatgggtg ccttccagcg gggcacgcag tccgggcggg ccgcgcacga
     1501 cgaccgcgcg ggccgcacgg accagacgag cggcaccacc ggtgccagca gtgaaggaca
     1561 tgaggtctcg tgaacgacga tctgtcatgg atgctcgaca gcgccctgga gattcccggg
     1621 gccctgcacg cggtcctgat ctccgccgac gggctgctga tggcccgtac caaggacttc
     1681 gacaaggaca acgccgaccg ggtcgccgcc gcgatgagcg gggtgcagtc gctcagccgt
     1741 tccctgggct tcttctgcga ggacccgcgg caggcctggc ggcagaccct ggtggagttc
     1801 gacggcggct gggtcttcct gatctccgcc ggtgagggcg cctacctcgg cgtctccgcc
     1861 agcccggacg tcgacatgca ggacatcacc ttccggatgc agcagctggt cggccagctc
     1921 ggcaaggcgc tcgccgcgcc gccgcgcgag aacctcggcg cgcgctcatg accgggccgg
     1981 gggagtggga gcccgaggcc gccgagttag tacggcccta cgtcatcacc aagggccgcg
     2041 gcctgcccga cgaggcggag ctgtccctga tcacgctcgt cacggcggca cccgagggac
     2101 cgcggcggcc cacccggctg tcccccgagg aacagcggct gctggacatc tgctccgccg
     2161 gctacctgtc ggtcgccgag atcgcggggc acacccggct gccgctgggc gtggtgaaga
     2221 tcctcctcgc cgcgctcacc gagggcggct acctcatcac ccgcccgccc gtcgcccgcg
     2281 cccccctcgc cgaccgggag atcctggagg aggtactgaa tggccttcgc gccaaattcg
     2341 gttgagccgc cacacgcggt cgagccgccg cacgcggtcg agccaccgca tgcggtcgag
     2401 ccggacaccg ccggggatcc gcccgctccg cacgccgggc cgggcacctc gccccggctc
     2461 ggcgcgcagg cctacgtccg cggcggcgcc acccagaccg ccgtcaagat cctcgtcgtc
     2521 ggacacttcg cggtgggcaa gaccaccttc atcggcacga tctccgagat cgagccgctg
     2581 tccaccgaag agaccatgac ccgggccggc gaggagatcg acgacctcaa gggcgtcacg
     2641 ggcaagacca ccaccacggt cgccatggac ttcggccgcc tcaccatcag cgaccgggtc
     2701 gtcctctacc tcttcggcac gcccggccag cagcggttcg tgcagatgtg ggaggacatg
     2761 gcccgcggcg cgctcggcgc gctggtcctc gtcgaccccg agcggctcgc ggactccttc
     2821 caggtcatcg acctgatcga gcagtacagc ctcgactacg ccatcgccgt caaccacttc
     2881 gacggcgccc cgctgcgcga cgaggccgcc ctgcgcgagg ccctggacct gctcgacgac
     2941 acccccgtcg tcacctgcga cgcccgcgac gagaagtcgt cggccgccgc cctgaccacc
     3001 ctggtccgct acctgctgga ccgcgtccgc taggacacgc cccagaggcc cccaggacga
     3061 tcagagacac ccgaggacga cggtcctccg gctcccccga gaactgagag cagacatgga
     3121 cgctcacacc cccgccccgg tccccccgcc ggggtgcccg gcccatggtt ccggcggccg
     3181 ggtgccgctg tacgggccgg agttcgcggc cgacccgcag gcgtactacg ccttcatgcg
     3241 gcactacggc cccaccgccc ccgtggagat cgcccccggc gtcgaggcga ccctggtcac
     3301 cgactaccag gccgcgctcc agctcctgca ggactccggc accttccgca aggacgcccg
     3361 ccgctggcgc gacttcaacg agggtcgcat ccccgccgac agcccggtcg cgcctgtgct
     3421 cgcctaccgg ccgaactgca tgttcgccga cggcgccgag cacctcaggc tgcgtcaggc
     3481 cgtcaccgac agcatggccc gcgtcgactc gcgccgcctc agccacaccg ccgagcaggt
     3541 ctccgactac ctcatcgagc agttcgccgc ccgcggctcg gccgacctgc tcggcgacta
     3601 cgccaagcag ctgccgctgt tcgtcttcaa cgaactcttc ggctgccccg ccgacatcgg
     3661 cgaccgggtg ctgttcggca tctccgggat gttcgacggt gtcaacgccg agaaggccat
     3721 gggcgtgatg ttcggcgccc tcggcgaact cgtcgcgcag aagcgggccc ggcccggcga
     3781 ggacgttacg tcctggctga tggcccatca ggcacgcctc accgatgagg agatggtcca
     3841 ccagctggcc ctgctgatgg tggccggcaa cgaaccgctg cggaacctca tcggcaacac
     3901 cctgcaccgg ctgctcaccc acgacgcgta cgcccaccgc ggcggactca tcgacgaggc
     3961 gctcgacgac acgctgtggg agaacccgcc catgcagaac ctcgccgcgc actacccggc
     4021 cgccgacatg gagttcgccg ggaccaagct ccaggccggc gacctggtcc tggtgagctt
     4081 cgccgccgcc aacacgggcc ccacgctcac cgctgcccgg caagccggca gcaaccgcgc
     4141 ccacctcgcg tggagcgccg gcccgcacgc ctgcccctcc aaggatcccg cccggcagat
     4201 caccgtcacc gcggtcgaga acctgctcaa ccggctcccg gacgtcgaac tcgccgtccc
     4261 cgaggacacc ctggcctggc gccccggccc cttcaaccgc ggcctgacca ccctgccggc
     4321 ccggttcacc ccggtggagt ccgtccgccg cgcggccccc gagccgcgtc cggcggcgcc
     4381 cgcgcacccc ggcccggccc cggccgccgc ccgcaagggc gaacgcggcg gcctgtggag
     4441 ccagttcctg aactggctca tcaagtgaga cgacctgtca agtgattcac acaacaccca
     4501 ccaacccccc ttgatcgcat gacggttcaa tcacaggggt agtcaggaac gcggcgttcc
     4561 gtgttgctga cgaggcaagg gagggtgtcg tggaccacat atccgcgtac tccactacca
     4621 gaccgcaccc ctggcacccc ccgatacccg cccccgcagg cgggtatctt catgcgggcc
     4681 ccgagacgtc cggcatcgca gaccacatcg ggaacccagg caccctgggc tcgctcaccg
     4741 ccggtcagct gcggcggctg tgcgccgtcg cgggactggg cccggccgcc gccgacggct
     4801 acgcccgtac cctcgtcggg gcgctgggcc cggtcgccga ccgcccgctg gacctgccgc
     4861 cggtcacccc gacgttcctc tccgacgacc acaccccggt ggagtactcc ctctccttca
     4921 ccccgggcgc ggcccccgct ctgcgcgtgc tgctggaacc gggctgcggc gcaggcagcc
     4981 tggctcgcag cggtcgcgcg ggactcgcgg ccgtccggga gatggctcgg cgctggaact
     5041 tctccaccgc cgtgctcgac gagctggagg acctcttcct gccgcccgcg cccgagggtc
     5101 cgctcgccct gtggtgcgcg ctggagctgc ggcccggcgg cgtaccgaag gtgaaggtct
     5161 acctcaatcc ggcggcccgg ggcgcgggcc gcgccgccgc gaccgtgcgg gaggccctgc
     5221 ggcggctcgg tcaccggcgg gcgttcgacg cgctgcctgc ggccgacgga catctgttct
     5281 tcgcgctgga cctcggcgac tgggacgaac cccggctcaa ggtctacctc gcccaccagg
     5341 acctgaccgc ccgtgcggcg ggcgggctga gccggatgga ccccggcccc ggtgaggcgg
     5401 agatccgcgc gttcttccac ctggccaccg gcaccggcac cggtcccgac ctcggtgccg
     5461 gcacggtcgg cggaaccggc gccgtacggc tcgaccggcg gcccggccag tcctgccacg
     5521 ccttcaccga gaccgcgagc ggccggccga gcggcttcac cctctacatc ccggtacggg
     5581 actacgcccg cgacgacgag gaggcgctgg cacgggcgga ggccgtcctg gaccgctacg
     5641 gcatggaccc cgttccgctg ctcgccgccg tgccggccct caccgcccgc cgcccggcgg
     5701 acggcgtcgg gctcgtcgcc tacctcggcc ttgcccacca gcagggccgc ccgccgcgcg
     5761 tgaccgtcta cctgtcggcg gaggcctacg cggtccggcc gcccgcgggc acgcccaccg
     5821 cctgtcccga acccgtgtcc tgagccgcgc cccgaaccgg tgttctgggc cgccgcgcgg
     5881 ctcccggtgg gaccgggagc ctcagcggcc gggcctcacg cgtcctgcaa ctcccgcaga
     5941 tacgcgccga cgtcgacctg gatcgacgta ccctccgtcc tgccgtaccg ctcctcgatc
     6001 ccgctgagat acgccgctat ctccttgcgc atgacgtccg cggagggcag ggacgcctcc
     6061 ccggcgacga gccgcgccac ccagcgggcc tgggcctcga cgaggcgggt gatggagccg
     6121 tgcgggcgga tcaggccgag gaagtacagg ccgggacggt ccggggcgac gacacggcgg
     6181 tacagctcga ccgggccgcc gtcacccgcc gggcagccgg ccggcaggaa cgggaaggac
     6241 atgcggaagc cggtgcagta gaccaccgcg tcggcctcct ccgcggtccc gtccgcgaag
     6301 aggacccggc cgccgtcgaa agcctcgatc gcgggcttgg ggacgaccgc gccgtgccgg
     6361 atccggctga ggatctcgtc ggagatggtc acggccgagg agaagacggg gtggtcgggc
     6421 tcgggcagcc cgtagtctga cagcctgccg cgcgccacca gcagcgcctt ctccacccag
     6481 gcgcgttgct cggggaagga catcgcggtg aaccacgggg cgtccgcgat caggtccacg
     6541 ggtatgccga agagctgctt ggggatgatg tgcagtcccc ggcgcaccga cagcagggtc
     6601 cgcgcggcgt gccgcgacag gtccgcggcg atgtccaccg cggaggcgcc gagccctacg
     6661 acgaccacgc gctgtccggc gaagtcggcg ccgtcctggt agtccatcga gtgcaggatc
     6721 gttccggcag aggtgtcggc acccggcggc agcgggtcgg gcagggccgg tcgggtgttg
     6781 tgtccggagg cgacgatcac gtgctcgaaa ctccgcgtcc gctgcgcgcc ttcggcatcc
     6841 cggctgacca cggtccatga accgtccact tgctgacgta ccgtcaacac cttggtgcgc
     6901 agctcgatcc ggtccagcag cgtcgcccac tcggcgaacg accgcaggta agcggcgaca
     6961 tcgctgtgcc gtgggtagag gggcagggaa tccggcatcg gaaagtcggt gtaacccgtc
     7021 agctgccggg cgctgttgag atgcagggcc cggtaggccg ggccgcgctc acccgcttcc
     7081 ggctgccgcc agatgccgcc gacgtccggc gccttctcca ggcagaccac gtcgacaccc
     7141 ctcgccttga gcgcgtgtgc ggccgccagt ccggacaggc ctgcaccgat cacgcacacg
     7201 ctcacgccgc cccccacact tcgaacacgg tttctctatg cacggccatt gactgcccaa
     7261 cgcgctcacg gctcacaccg gcaccagggg ccaccggctg aggcgtacgc cacgcccgag
     7321 aaggacagtt ggggcgtgct acgacgcttc gggcggcgcc ggctgcgggg gcgccgtcgg
     7381 ccccagggtg cgccgggcca cccggtccag atgccgggcg aagaccttgc gggcgtcggg
     7441 ggtgagggta cgcagcgcga tcagggccgt gaacaccacg tcgcacagct cggcctgcac
     7501 gtcgtcccag ctgtgcgtgg tgcccttgcg cgggttctgc ccggtcgcgc cgatcacggc
     7561 ctgcgcggtc tcgccgacct cctccgacag cttcagcacg gccagcagca gtccttcccg
     7621 gccgccgatg ggctgccgtg cctccagcga ggcccacagg gcgtcgacgg tgtcccacag
     7681 accggctgcg gcgtcggctg ccgctggggt ggtggcggtg gcattggcgg tgtcgtcgtg
     7741 actcatgcgg ggcagcctgc cacgagcggt ccagtggccg gccggctgcc ggcccccggt
     7801 cgcccgtccc cggcctactc cgccaagtcc tcctcgaaca gcgcctcctg ctcgccctgc
     7861 ttctgccggc gcacccgctg gacgcgcagg cccacggcca ccgcggtggc cagcccggtc
     7921 gccgcgaagg cgaacggcac catccagccc cggtcgacgg tgtggccgag ggcgtggtcc
     7981 agggagagcc ggccgggtcc ggtgacggcg agaccggccg cggtcaggcc gagggaggcg
     8041 gcgtactcgt atccgccctc ctggttgaag aagccgttcg gggcgtgcac ggaggccgcg
     8101 cccgccatcg cgccggccgc cgccgcaccg gccgccgggg tggccaggcc cagcgcgagc
     8161 agcgtgccgc cgcccgcctc cgccaggccc gcggccatcg cgctgacctt gcccgggcga
     8221 tagccgacgg actccatgaa ctggcccgtg ccctcgatgc cgtggccgcc gaaccagccg
     8281 aacagcttct gcgcgccgtg cgcggccagc acgccgccgg tgcccagccg gagcagcagc
     8341 aggcccagat cacgtcggtc gtacaaggtc atggtggctc tcccaggcag acggccggcc
     8401 gtgcggcgcg ctcgacagca ggaacaggtc ccctccggtg gctccctccc ctgctccacc
     8461 gtcgcaccgg gggcggccgg ccaccccgcg cggagggccg ttcgggtggg agaggccccg
     8521 gccgggcccg gagagatctt cacgacccgc ggtcatctgg aggtcgacag cgagtccgac
     8581 gggggccgcg cgctgccggc ccgctacggc aacgacgcct ggggcgagat gcgtacccgc
     8641 cggcgcttca ccgtcgagga cgacggccgt atctcccgct tcgagacggg ccaggcctga
     8701 cgccggtccg tggtgtccgg cagccgtccc gccccccggt gcgcacctcg cggtccctcg
     8761 cgaggtccac ccccacccgg tacggcggga cggctgccgc ttccccccct cggtatggct
     8821 tgcggaatac cagtgctcca agtgtgaagt tctggtggag gagagttgag cataagtcct
     8881 ctaccggccg caatacctcg gaagttcaca ttccgcttgt gcagatcgtg gcggttgtgg
     8941 aaggcgccct gatcagccgc gccccacgta cggcatcgtc gtcgcgagca ccgtcgcgaa
     9001 ctgcacgttc gcctccagcg gcagctcggc catgtgccgc accgtccgcg ccacgtcggc
     9061 cacgtccatc accggctccg gcgcgatctc cccgttggcc tggagcacgc ccttctgcat
     9121 acgggccgtc atgtcggtcg ccgcgttgcc gatgtcgatc tgcccgacgg cgatccggta
     9181 cggccgcccg tccagcgcca gcgacttggt cagccccgtc agcgcgtgct tggtcgcggt
     9241 gtacggcgcc gagtgcgggc ggggcgtgtg ggcggagatg gagccgttgt tgatgatccg
     9301 gccgccctgc ggatcctgct ccttcatctg ccggtaggcc gcctgcgcgc acaggaacgc
     9361 cccgttgagg ttggtgtcca ccacgtgccg ccacgcgtcg aaggacagct cctccaccgg
     9421 caccccgccc ggcccgaacg tgcccgcgtt gttgaagagc aggtcgacgc ggccgaaccg
     9481 ctcgacggtc gccgcgaaga gcgcggccac gtcctcgggc cgcgccacat cggtgcgtac
     9541 gacgagacag gtgccctccg gcaccagcgc cgccgtctcc tccagcgtct cggtacggcg
     9601 cccggccagg gccaccgacc agccggcgcg cagcagctcc acggcgaccg cgcggccgat
     9661 gccggagccg gcgccggtca ccaccgcgat ccgggagcgc ggggggcgtt cggggtttcg
     9721 ctcggtgttc atggcctggc agcgtaggcg aaggtccaca gtgtgaaacc cggcattccg
     9781 ccatccgggc acccccggcg tcggctcaga gggagagcag tgccccggcg ccgtcctcct
     9841 ccgggctctc cgggttctcc gggttctcgc ccggatagcg caccccgacc cgctcgcgga
     9901 tcgcgtccag cgtgcgcatc accgccagcg tgccgtccag cggcaccagc ggcgactccg
     9961 tctccccggc ccgcagcgcc cgcatgacct cccgcgcctc gtgccggaac gtgccgcgcg
    10021 gcccgtcggc cgggtccgcc gtgaactcct cggggtcacg gccgtcccgg tgcagcacga
    10081 accgctccgg gtggaagaac ccgtccggca cgtcgatccg cccgtgcgag ccggtcaccg
    10141 acgccgtcac ccccgtaccg ccgacgatcg agcagtgcac cgacgccagc gccccgctgt
    10201 cgaacgacag cagcgccccc gtctgcaggt cgacgccctc cggggacagc acggcccgcg
    10261 ccgccacgtc ggccggctcg ccgagcagca gctgggcgaa ggagaccggg tagaccccca
    10321 ggtcgagcag ggcgccgccg ccctggtgcg ggtcgcgcag ccggtgcgcg ggcgggaacg
    10381 ggccggccag gccgaagtcg gcctgcacgg tgcgcacctc gccgatggcc ccgtcgtcca
    10441 cgagcgcctt cagccgccgt accagcggat ggcagtacat ccacatggcc tccatcagga
    10501 agctgccgtg ctcgcgggcg agggcgacca gctcctccgc ctggcggacg ttcagcgtga
    10561 acggcttctc gcacagcacg ttgcgcccgg cctccagcag cagcccggcc gccgcgcggt
    10621 gcgccgcgtg cggggtggcg acgtacacca cgtcgacgtc gtcgtccgcc gcgagggagg
    10681 cccagtcgcc gtaggcgcgc gggatgccga agcggtccgc gaacgtcttc gccgaggcct
    10741 cgctgcgcga cgccaccgcc acgacctcgg cgtccggcag atccaccaga tccgcggtga
    10801 acgcggcggc gatcccgccc gtcgccagca cgccccaccg caccgtgtcc gccgtcatac
    10861 ccgccccacc ctctgttgcg tcttcaagca gcctgtacga gctgagagca taggggccgc
    10921 atctgtcgaa gagggagggc cgcatgcccg agggtggggc acacagaccg cagacgacgc
    10981 ggagggggcg ggccgagccg gcggccggga cgcggccggc cgccccggga ccgcaccgcc
    11041 gaaccggact gctcgtcacc ctcgtcctcg gcggactgac cgccacaccc ccgctggcga
    11101 tggacatgta cctgccgtcg ctgccggagg tgacccgcac cctgcaggcc cccgccgcca
    11161 ccgtccagct caccctcacc gcctgccttc tcggcatggc actcgggcag ctggtcgtcg
    11221 gacccatgag cgaccgctgg ggccgccgcc gcccgctgct ggccggcctc gccgtgtacg
    11281 tcctcgccac cgccctgtgc gccttcgccc cgaccgtcgg gacgctggtc gccttccggc
    11341 tcgcgcaggg cctcgccggg gcggccggga tcgtcatcgc ccgcgcggtc gtccgcgacc
    11401 tgtacgacgg tgtggccatg gcccgcttct tctccaccct catgctcatc tccggcgtcg
    11461 cccccgtcgt cgccccgctc atcggcgggc agatcctgcg ggtgacggac tggcggggcg
    11521 tcttcgtcgt gctcaccgtg gtgggggcgc tgctcggcac gctggtgtgg ttccggctgc
    11581 cggagacgct gccgcccgcg gaccggcact ccggcggcgt cggcgaggcc ctgcactcga
    11641 tgcgccggct cctcaccgac ctgcccttca ccggctacct cctcgcgggc ggcttcgcct
    11701 tcgccgccct gttcgcctac atctccgcct cgcccttcgt cgtccaggag atctacggcg
    11761 cctccccgca gaccttcagc ctgctcttcg ggctgaactc cgtcggactg gtcgtcgtcg
    11821 gccagatcaa cggcaaggtc ctcgtcggcc gggtccgcct ggaccgggtc ctcggcgcgg
    11881 gcctcgccgt ggtgatcctc gcggcgacgg ccctgctgct catggcgacc ggcgccttcg
    11941 gcgacgtggg cctcgccccc gtggccgccg ccctgttcgt gctgatgtcc gcgatgggcg
    12001 tcacgctgcc caacacccag tccctcgcgc tgctgcgcac ccggcactcc gcggggtcgg
    12061 cgtccgcgct gctcggcacg tcgtccttcc tcatcggcgc gatcgcctcc ccgctcgtcg
    12121 gcgtcgccgg ggagcacacg gccgtgccca tggccgtggt ccagctgacg gcgggggtgg
    12181 tggcactggc ctgcttcctg ggcctgtgcc gcccctggcg gacgggtacg gacggcgggg
    12241 accggggcgc cccgggcgcc gtcggggccg agaacgcggg agcgggacac tgagcgcgcc
    12301 gagactgcgc cgggacaccc ccgagcgggc cggactcgac cccgacgagc tgggacacct
    12361 ggtgcgcgag gtccgcgacc tcaccaccgg gccccgcccc tgggcggcgg gcgccgtcgt
    12421 cgtcgccgga cgcggccccg tcgtggcggt ccacgaggcg gcgggccacg ccgtccggta
    12481 cgccgcctac gaccccgcca ccgacaccgg cgtcgaactc cccccggccg accgggtgcc
    12541 catgaccgtc gacaccccct tcgatctggc ctccctcacc aagctgtgca ccgcggtcgc
    12601 cgccgtgcag cagatcgagc ggggcacgct cggcatcgac gccctggtcg gcgcgtacct
    12661 gccggagttc cgcggggccg ccggcgcggg cgtcaccgta cggcagctgc tcacccacac
    12721 ctccgggctg cggccggagc tgcccctgta cgactgcgcg gacgacgcgg aacgcctggc
    12781 gctcctgcgc gcggaggccc cgtccgcacc ccccggcacc tacctctact ccgacctcaa
    12841 cctgctgctc ctccagcacc tcctggagcg cctcaccggc cgccccctgg acgtgctggt
    12901 ccacgacggc atcacccgcc ccctcggcat gaccgccacc cgcttcgggc cgtgccccgg
    12961 cgcggccgcc accgaggacc agcgcaggcc ctgggccaag gccgaccggg gcatgctgcg
    13021 cggcgaggtg cacgacgaga acgcctgggc gctcggcggg gtcgccgggc acgcgggcct
    13081 gttctccacc gcgtgggacc tggcggtgtt ctgccggacc ctgctcgcgg gcggctccta
    13141 cggcccggcc cgcatcctcg gccccgactt cgtggagctg ctgctcaccc cgccgggcct
    13201 gggcttcgcc gtggaccagc gctggttcat gggcgacctg gcaggccggg gcgcggcggg
    13261 ccacacgggc ttcacgggca cgtcgctggt cctggacccg gcgacggaca ccttcctcgt
    13321 cctgctcgcc aacacggtcc acccacgccg ccgcaccccc gacagcggcc ccagggcagc
    13381 ggcggcgacg cgactggcgc gggcggtgcg gggggtgggt gcggcctgag ggacccggag
    13441 gggacggcct gcgggagcga ggctgtgacc ggctgatgaa accagggtct gaccgcctga
    13501 tgaaaccagg gtcggaccgc ctgagagaat cgtccggtga acgtccccgt gtcctcctcg
    13561 cccgccgaca ccctgcgcac cgcgctctcc ggcctgctcg acggcctgcc gccccggcag
    13621 gccgcgcagg ccgtggagcg gctgatcggc cactaccggg gggccacccc gaccgacgcg
    13681 ccgatcctgc gtgaccgggc ggacgtcgcc gcgtacgccg cctaccggat gccggcgacc
    13741 ttcgaggcgg tgcgctcggc gctggcggcg ctcgccggcg ccgcgccgga gtggacgccc
    13801 tccgggcacg tggacgtggg cggcggcacg ggcgccgcga cctgggcggt caccgcggtc
    13861 tgggacggca cccggcccac caccgtcctc gactgggccg agcccgcgct cgccctcggc
    13921 cgggagatcg ccgcggccaa cccggccctg cgggacgccc gctggcagcg ctcgcgcatc
    13981 ggcacggcgc tcaccctggc ccccacggac ctggtgaccg tctcctacgt cctcaacgaa
    14041 ctcaccgccg ccgaccgggc cgccctcgtc gacgccgccg cgaccgccgc gcaggccgtc
    14101 gtgatcgtcg aacccggcac ccccgacggc tacacccgcg tcctggaggc ccgcgaccgc
    14161 ctgatcgcgg ccggcttcca ggtggccgcc ccctgcccgc acagcgcggc ctgcccgatc
    14221 gcccccggca cggactggtg ccacttctcg gcgcgcgtca gccggtcctc cctgcaccgc
    14281 caggtgaagg gcggctccct gccctacgag gacgagaagt tcgcctacgt cgccgcgacc
    14341 cgcttcccgg ccaccccggc cccgacccgc atcatccgca agccccagat ccgcaagggc
    14401 caggtcctgt tggacctgtg cgagccggcg gaacggctgg accgggtgac ggtgacgaag
    14461 cggcacgggg atctgtacaa ggcggcccgg gacgcggagt ggggggacgg ctggccggcg
    14521 gccgactgac ccggtgccgc cgtgggcctc tcgccgcatc ccgcgtccac ggcccgcccg
    14581 gaccgctacc gtcgccctgc acacgacagc gacgaggggc ggtgggcgat ggcgccggtg
    14641 ggtgcggctc aggtgtgggt gtgggtgacg gcggtggcgg ccggggtggt gacggtcggg
    14701 ctggtcctcg tcatggtgct ggtggacatg gacacggccg ggcaggtcgc caccgtgacc
    14761 ggcaccgtcc tcagcgcggc ggcgctgctg gtgtcggtcc tcgccctggc gggcggcggc
    14821 gggagcgggc ggaccgtacg ggccggccgg gacggcatcg ccgtcggcgg ccatgtgacg
    14881 ggctcggcac tcggcaggga cgcgaaggtc tccggcgcgg cgacaccccc cgcggccacc
    14941 gcgcccgccc cggacgccga cgtccgctcg gcccggggcg gcgtggccac gggcggcgac
    15001 gtcacggacg gcgcgctggg gccgggcagc cggcgggaca tcacctgacg tcctcgcgag
    15061 acgacgcgtc ttgtggggct ggtatgttcg ggacatgccc gacccgcagc cccgcaagca
    15121 ggccccggac gccactcgcc gcagccagcg gtcccggcag gcgatctacg acgccgccct
    15181 cgcgctcgtc gccgaggtgg ggtatccgaa gaccaccgtc gagggcatcg ccgcccgggc
    15241 cggggtcggc aagcagacca tctaccggtg gtggccctcc aaggcggacg tcctgctgga
    15301 ggccttcctc gacctctccg cgcaggccgc cgagcaggcc ggggcgcagc ccggggagcc
    15361 gtacgccctc cccgacaccg gtgacctcgc cgccgatctc aagggcgtgc tccgcgccac
    15421 cgtcgacgag ctgctcgacc cccgcttcga gacccccgcc cgcgcgctcg ccgccgaggg
    15481 actggtcaac gagcaggtcg gccgggagtt cgtggccaag ctcctcgaac cgcagctcca
    15541 gctctacgtc gaccggctgc gcgccgcgca ggacgccggg caggtccgcc ccgaggtcga
    15601 tccgcgcatc gcgctggagc tgttcgtctc acccctcgcc cagcgctggc tccagcacac
    15661 cggcccgatc tcctacgact acacggacac cctcgtcgac tacgccctgt acggcctcgc
    15721 cccgcgcgtc tagggggtgc ctcgccgatc aggccggatc agcgagcggt gccagacacc
    15781 gggagcccgg catgatcggc gaggcacccc ctagggggcg tctcgtccca cctgcccgga
    15841 att
//
