LOCUS       NZ_BNBR01000008        39362 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence08, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000008
VERSION     NZ_BNBR01000008.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 418315)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 182596
            Orig. end                         :: 221958
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..39362
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..39362
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..39362
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:29362]"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..29362
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            95..775
                     /locus_tag="IE308_RS32280"
                     /old_locus_tag="GCM10018783_65380"
     CDS             95..775
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010354244.1"
                     /locus_tag="IE308_RS32280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65380"
                     /product="hypothetical protein"
                     /protein_id="WP_190220603.1"
                     /transl_table=11
                     /translation="MTTVDHTPYTFLISANNPVPLSGPVPPHLPPDAETPATIRRTGQR
                     PEEPPLARVVTPRLDRRWSRKAPVPFWIHSGPDDALLCSVHPAGPDSYEVHAADGTPLA
                     RVTRHPGRFLPWPRRVRWSADPAGSFGQVTGREGTRWGWLTYVVTSPVWFLWVVGMTLF
                     SFFDGSPDDFTFGRPSRTRWHAPGTGTVLDYRGRRKTCRHDPGHLDSRTAYALAVLRTW
                     SASR"
     gene            complement(778..1857)
                     /locus_tag="IE308_RS32285"
                     /old_locus_tag="GCM10018783_65390"
     CDS             complement(778..1857)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020140272.1"
                     /locus_tag="IE308_RS32285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65390"
                     /product="endo-1,4-beta-xylanase"
                     /protein_id="WP_190220604.1"
                     /transl_table=11
                     /translation="MRQVRTTSAALLAAGALLLGAGAQTASAASDTQAPGMPLRAAAER
                     AHLKFGTAVNTTALAEDADYRRITGREFSSVTAENVMKWEVVEPQRGVYDWTAADQLID
                     FARAHGQSVRGHTLLWHNQLPGWLTQGVADGTIDSAELREILHDHIKTVVTHFKGKLYQ
                     WDVVNEVFNDDGTYRDSLWLQKLGPGYIADAFRWAREADPKVKLFFNDYNVEGVNAKST
                     AYYELAKQLKAQGVRVDGFGIQGHLSTQYGFPGDVGANLKRFADLGLQTAFTEVDVRIP
                     LPADATKLATQADYYRGLLSACLGSTSCTSFTVWGFADQYSWVPDVFDGEGAACLYDES
                     YRRKPAYEALRQELRQGRR"
     gene            complement(1878..5015)
                     /locus_tag="IE308_RS32290"
                     /old_locus_tag="GCM10018783_65400"
     CDS             complement(1878..5015)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327073.1"
                     /locus_tag="IE308_RS32290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65400"
                     /product="glycosyl hydrolase 115 family protein"
                     /protein_id="WP_190220605.1"
                     /transl_table=11
                     /translation="MTRDVSRRTVLGTGMAAGLGAALPPVTAEAAGGAEAATRAPRPTD
                     PGAYVTFRPEPGAFPLVRSGRAVPVLVDAADHPGVRRVAADLRADIERVTGVRPAAERG
                     SAREIAIVGTVGHSPLLDGLIAAGKLDVSAIRGKWETSLQTVVEHPLPGVDRAFVIAGS
                     DQRGAIFGAYDVSRGIGVSPWHWWDDVRPVRRRQIFVRPGAWTQGTPTVRYRGVFINDE
                     NPNLGTWAPRFFGPGKAPGYPGGFTADFYAKVFELLLRLKANYLWPAVWGRAFAEDDPD
                     NHARATEYGIVVGTSHEAPMMRGIEEWNRHAVPAKRDAAGNIVTPGHDPYGGTGEWSFR
                     RNRAAIEAYWREGVRRMADQGIEGVVTLGMRGNGDTSLPDGDAIELMHEIIATQRRIIA
                     EVTGSETSVPQVWTLYKEVQRYWTRGLRAPDDVTVVLCDDNWGNIRMHPDPAEPPRKGG
                     YGLYYHFDYVGDGRNYKWVDTVNLPNLWDQLHQAVAYGNTTLWVTNVGDLKGNELPTHF
                     FMDYAWNPGRWTLGALSEWERRYAALHFGEEHAEAIAGLLARYGHLQHRRKPELLNRRI
                     TLDPTKDLATDDSAVLYDDQQTPFYWGELERVTEDWRRLGKDAARVARDLPASASDAWF
                     ELVGYNIQATANLYELREAEFTNLLYARQGRAATNDLAAKAEAGLAEDFRLQDVFNQEI
                     AGGKWQDFQLQPHIDYGDVERYGPNAPWQQPERDNVAIPDVLFPAVRRIEVPDVAEMGV
                     AVTGSEDWWPGSGEPGPVLPEFSPYRTDPTGTYVEIFNRGTRAFPYRITASVPWLRVDR
                     PRGTVRQQTRVAVTVDWAKVPAGRAEGQLTVEGAGRTVTVRAVASPLSPRGLKGFVEAG
                     GYVAIDAEHYTRAVGTRDIGWLRVDRLGRTGAGMTPVPVTAPAQTPGGNGPRLEYDVTL
                     LTPGEVTVWAYLSPRNPALARPGLRYAVSFDDAPPQTVDVIAVTGPDDGGLNRRWERHT
                     SDNVNRTSTRHRIAEAGVHRLRFWMVDPTVVVQRLLIDTGGLPETYLGPLESHRIH"
     misc_feature    complement(5136..5149)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.95"
                     /tool="antismash"
     gene            complement(5254..6447)
                     /gene="tuf"
                     /locus_tag="IE308_RS32295"
                     /old_locus_tag="GCM10018783_65410"
     CDS             complement(5254..6447)
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="tuf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004927329.1"
                     /locus_tag="IE308_RS32295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65410"
                     /product="elongation factor Tu"
                     /protein_id="WP_110629808.1"
                     /transl_table=11
                     /translation="MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDAYPDLNE
                     ATPFDNIDKAPEERQRGITISIAHVEYQTEARHYAHVDCPGHADYIKNMITGAAQMDGA
                     ILVVAATDGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEIMELVELEVRELLSEY
                     EFPGDDLPVVRVSALKALEGDAQWTQSVLDLMKAVDESIPEPERDVDKPFLMPIEDVFT
                     ITGRGTVVTGRIERGVLKVNETVDIIGIKTEKTTTTVTGIEMFRKLLDEGQAGENVGLL
                     LRGIKREDVERGQVIIKPGSVTPHTEFEAQAYILSKDEGGRHTPFFNNYRPQFYFRTTD
                     VTGVVHLPEGTEMVMPGDNTEMRVELIQPVAMEEGLKFAIREGGRTVGAGQVTKIVK"
     gene            complement(6604..8730)
                     /gene="fusA"
                     /locus_tag="IE308_RS32300"
                     /old_locus_tag="GCM10018783_65420"
     CDS             complement(6604..8730)
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fusA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379465.1"
                     /locus_tag="IE308_RS32300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65420"
                     /product="elongation factor G"
                     /protein_id="WP_110629807.1"
                     /transl_table=11
                     /translation="MATTSLDLAKVRNIGIMAHIDAGKTTTTERILFYTGVSYKIGEVH
                     DGAATMDWMEQEQERGITITSAATTCHWSLDDVDHTINIIDTPGHVDFTVEVERSLRVL
                     DGAVTVFDGVAGVEPQSETVWRQADRYGVPRICFVNKLDRTGAEFHRCVDMISDRLGAQ
                     PIVMQLPIGAEADFKGVVDLVRMKALVWSAEATKGEMYDVVDIPATHTEAAEEWRGKLL
                     EAVAENDEEIMELYLEGEEPSEEQLYAAIRRITIASGKGQGTTVTPVFCGTAFKNKGVQ
                     PLLDAVVRYLPSPVDIEAIEGHAVDNAEEVIKRKPSDEEPLAALAFKIMSDPHLGKLTF
                     VRVYSGRLESGTAVLNSVKGRKERIGKIYRMHANKREEIASVGAGDIVAVMGLKQTTTG
                     ETLCDDKSPVVLESMDFPAPVIEVAIEPKSKGDQEKLGVAIQRLAEEDPSFQVHTNEET
                     GQTVIGGMGELHLEVLVDRMKREFKVEANVGKPQVAYRETIRKSVEKVEYTHKKQTGGT
                     GQFGRVIISVEPIEGGDMSYEFVNQVTGGRIPKEYIPSVDAGCQEAMQFGILAGYEMTG
                     VRVTLLDGAYHEVDSSELAFKIAGSQAFKEAARKASPVLLEPMMAVEVTTPEDYMGDVI
                     GDINSRRGMIEAMEERAGARVVKGLVPLSEMFGYVGDLRSKTSGRASYSMQFHSYAEVP
                     RNVAEEIIAKAKGE"
     gene            complement(8770..9240)
                     /gene="rpsG"
                     /locus_tag="IE308_RS32305"
                     /old_locus_tag="GCM10018783_65430"
     CDS             complement(8770..9240)
                     /GO_component="GO:0015935 - small ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012245571.1"
                     /locus_tag="IE308_RS32305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65430"
                     /product="30S ribosomal protein S7"
                     /protein_id="WP_003998848.1"
                     /transl_table=11
                     /translation="MPRKGPAPKRPVIIDPVYGSPLVTSLINKVLLNGKRSTAERIVYG
                     AMEGLREKTGNDPVITLKRALENIKPTLEVKSRRVGGATYQVPVEVKPGRANTLALRWL
                     VGYSRARREKTMTERLLNELLDASNGLGAAVKKREDTHKMAESNKAFAHYRW"
     gene            complement(9243..9614)
                     /gene="rpsL"
                     /locus_tag="IE308_RS32310"
                     /old_locus_tag="GCM10018783_65440"
     CDS             complement(9243..9614)
                     /GO_component="GO:0015935 - small ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020488528.1"
                     /locus_tag="IE308_RS32310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65440"
                     /product="30S ribosomal protein S12"
                     /protein_id="WP_003948652.1"
                     /transl_table=11
                     /translation="MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKP
                     NSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDT
                     QGVKNRKQARSRYGAKKEK"
     misc_feature    complement(9833..9848)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
     misc_feature    9974..9983
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            complement(10001..10456)
                     /locus_tag="IE308_RS37115"
                     /old_locus_tag="GCM10018783_65450"
     CDS             complement(10001..10456)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: thio_amide"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605017.1"
                     /locus_tag="IE308_RS37115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65450"
                     /product="hypothetical protein"
                     /protein_id="WP_229909305.1"
                     /sec_met_domain="thio_amide (E-value: 9.3e-36, bitscore:
                     116.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEHPAQQLYCTVVLWDLSRSAATVASLRAYLRDHAVDAYATVPG
                     LRQKTWISSTGPEGEQWGAVYLWDSPEAAYGRPPGVSKVVELIGYRPTERRYYSVEAAT
                     EGPAAAAAPFGKGLGLAFDPASPEPLTRPQEFVPPGADAFIPARPPA"
     gene            complement(10453..11406)
                     /locus_tag="IE308_RS32320"
                     /old_locus_tag="GCM10018783_65460"
     CDS             complement(10453..11406)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IE308_RS32320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65460"
                     /product="cytochrome P450"
                     /protein_id="WP_190220606.1"
                     /sec_met_domain="p450 (E-value: 6.3e-21, bitscore: 69.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALADPERHARWRRTLATVLTPRHAESLRKAVGQAVDEVLDGLAE
                     AGPEPVDLVSGFAYQVPVRVLCELFDLPEELRPGLWGWAAQVRAAAPSTAAFGAAMGAL
                     FGVARQLVEKELAAPGDGLIGSLIAGLDEDARPSADELVSTVVLLATAGYESTAVQFAN
                     GLLALFQHPDQLARLRDGTVTEAAAVEEILRYAQAGTGFAGTTVTTEEVTLGGITLPEG
                     ATVFISLDSAARDERHVDRPDTFDLARGAARTHLTFGAGAHYCLGSSLARVELQEGLGR
                     LLRRFPALTPAADPAAVEFTANLFHRYPRELKAVLR"
     gene            complement(12249..13475)
                     /locus_tag="IE308_RS32325"
                     /old_locus_tag="GCM10018783_65480"
     CDS             complement(12249..13475)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IE308_RS32325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65480"
                     /product="cytochrome P450"
                     /protein_id="WP_110629804.1"
                     /sec_met_domain="p450 (E-value: 4.3e-31, bitscore: 102.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIEARTYPFTRHTPFEMPEEFAWLRENRPIAQVRLATGDTAWLI
                     TRYEDVRTALTDPRFSRTINREGAARVDTGFQADADSPVFNFGGSISEPPGHTRWRRLV
                     NQAFTARHAESMRPAVAAHTDALLDDLESAGGRFDLMADYAYQLPIRVICDLLGLEQTA
                     RPEFSALAAQITRRDFTSSFVEFGQALQAIGRYAIGLIVRKRQNLGDDLLSTLIGLTDE
                     EDGRLSNEELVSTVILLLMAGYESTAVQLGNAFYALFRDPSQMRRLREEPALIGQAVEE
                     ILRYAQMGTGYAIAKFTTEDVELSGGTVPAGSTVFVSLASANRDEKVFGEDADRFDVGR
                     GCAHRQTAFGYGPHYCLGAALARVEMQEGIARMLNRFPDLRFDGPDLDGVPLASNLFTF
                     YPAELPVRI"
     gene            complement(13494..14531)
                     /locus_tag="IE308_RS32330"
                     /old_locus_tag="GCM10018783_65490"
     CDS             complement(13494..14531)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.5"
                     /locus_tag="IE308_RS32330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65490"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_190220607.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.1e-54, bitscore:
                     179.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPETGPWHSLHLHRYADQDAFLVDGLAPVLAPLHASGALESSF
                     FLRYWQGGHHIRLRLRPAAHDPEQAARTVREVADRLAGHLAAHPGGYGDLDPEEFREAQ
                     LTMAALESEATGELLPPDTVHPARYEPEYGKYGGPEGVAVAERFFDRSSAVALSALRAI
                     GDRPARRLGAAFTMTLRGLCAARLSPPAMAAFLAHYCAVWSPYVFDSFLDTWPELLDQR
                     RGPAAAHLRPLLAAAQPPDDPYGRAVGEAWQALHTAADRVLPAVTLGGPDAPAERRRQI
                     VLLSYLHTHNNRLGLIPEQEAFLGYLGHHVVADCAGLAPDTGLLDRVRDHRRERLAAHL
                     PSGQH"
     gene            complement(14518..17307)
                     /locus_tag="IE308_RS32335"
                     /old_locus_tag="GCM10018783_65500"
     CDS             complement(14518..17307)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="IE308_RS32335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65500"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_190220608.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.3e-43, bitscore:
                     140.8, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDTTRVPGAPDAAGAPDGFSPYYLYRRGTLGPSELAALTPARTW
                     ALLAEAEETRQRREELRGRLEDALHAAVPELPADRRHELLRLRRDIHNDRVPGVPDAAR
                     LLDPASRELLEDWLRHRAEGNRLHKEAEAALAAELDAGRRALAAIATGEFFQRGLQLSD
                     ERTWRTVTEWAADPFSARRKPSKRRRAENTLTSFAYRVALKPSPFASFTEIGAAPWTPA
                     GDGTAPAAPADRPPARPVQARLSAGLLSWMTYELHRLDRADELMRIRLNHSLLVREEQA
                     LCVRRAPDGAPEAAYGTAQVVTARDTGLLRLLRSLLADGGLPERELRERLTAAGLSPQA
                     AATALDKLVRAGICERGLGIPDQHPRPALAVAQRLRTLDTDQAGRCAVVFERLQAAEDA
                     FPAAPVRRRAALLAEIREQVAVFVEAVGCRAPAPEAMRSVVYEDVGTREPAHSWHPDLL
                     HANRWALELFQRIVPVLDDASVEKAGLYAFFARHFGAADGDGDVPFIEFYRRFAALPPA
                     EASAVASGVGDPHSDRIRRLRADFADLLRTELRAHDSAHTGALRLDAERLRAFADRLPA
                     EVTPWRSTAYRMQFTAEPERPYAVVNGVTTGHGVFFSRFCDLLEPDGPHEWSLTEALRG
                     HIARTTPRQCDITAVLGLNFNLHPRLSPYELVYPGSVPRAADEHALTLADLAVRADPAR
                     RTLTLVSTRDGQPLDLVPLNFLYPAAAPGLYRLLCAFAPTRTYRGGLWDQLDRADAEAG
                     RAAGRTGVPAAHRSLPRVLLGDLVLDRASWRLPAADVPDTDGLERQEAAALASFDRWLG
                     QRGIPRHTFFRLTTPPPVPAGERDLLAETRQWALEARTARLHKPHYLDARNPFLLQVFA
                     RRLAEAGPDATVTFQECLPHAGDLDGRTSGAEEFFVEYTLGTPAPAGTQATEDAHARP"
     gene            complement(17304..18947)
                     /locus_tag="IE308_RS32340"
                     /old_locus_tag="GCM10018783_65510"
     CDS             complement(17304..18947)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS32340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_65510"
                     /product="hypothetical protein"
                     /protein_id="WP_190220609.1"
                     /sec_met_domain="PF00881 (E-value: 4.9e-06, bitscore: 21.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMTTDEAYTYTTGLRLDPRSANPDGWRVDWADGPWPVKVYSGAR
                     RLPLRPDGPPPLAALHRLLHGGFAVSRIRTDPSGGIAATPADPRPHHGPEVQLRRPVPS
                     GGAMYPTEVYAALTATGQVCHYDPYRHELTVLAGGDAAARLRAALHLPTEAAPAAVLVL
                     TSRFWKNFYKYGDFATRLGLVDAGVALGRAARLARAEWEHAEVRTVFDDEAVHACLGLD
                     GEEENAWAAVTLGPYLPYRADTGGPDAPPRPALLERSRTVRRSDRFTAFQRAAREDTST
                     AAPARPPEDAVPAAAPGPVPGDAVPAAAPGPVPGDAAPGPVPEDAVPVGPVPLPAPRAL
                     DLLAAETAARRFSRGRLFTGAEADGEALAGVLGQAAEALRALAGAGVDGPAGWAARTRL
                     YCAVHRVRGVPPGWYRYAHELGALLPVGEGTGPGSARRVQEALFAASFNAELAAFTVHP
                     VTPADWRPAGGPRAYRAQQLAVGAAIEAVTLAAAAEGLSGHAVLGFDVTLIDTAYGLDG
                     GADTDGGTQAQICVGAVRPDPNWEIAVMPR"
     gene            complement(18993..20963)
                     /locus_tag="IE308_RS32345"
                     /old_locus_tag="GCM10018783_65520"
     CDS             complement(18993..20963)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="IE308_RS32345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65520"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_190220610.1"
                     /sec_met_domain="YcaO (E-value: 3.9e-72, bitscore: 238.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.7e-96, bitscore:
                     317.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATTPQPRTGPAGPPVVVGRGVLAEHLVRRLGRDDTPDPDGGA
                     RFGRSSRATVLVAGLDGLGEFQDTVVDCLATGRSLLFVGSWRSLVYIGPVWRPGTQGCP
                     RCLVTRTANSPFGPGLEGDSLAESWPHGADVRIWGPGVLRLVEEYVRARLASCQGPAGP
                     ADGRVLVLDGAAGTVEQQTLLPDSGCPNCGSLREDTVPALTPAAVPLTKLTPATLRTGR
                     LPADAVRGDYLYAGLGLFKELRQDLQSPFGACSVELPPRWGRREPAIGRAADYATSRTV
                     AVLEGLERYAGLHRGGTLPPVRARYADVADQALYPPDLGTHPEESYASEGFRYRPFDPG
                     TEIDWVGAYSFRRDGRVLVPERAAFWGPRHDDEISFFYDTSNGCALGNSVEEAVLHGLR
                     ELAERDAFLLTWYRELDVPEVALDGTSPALDHLLAKSRLFTGFDFRCFDATMEYGVPAL
                     LLTAENDSGDGPRLFAGCGAHPDPVQAVTGALHELVGTVLATRDAYERRRPDALRMLDD
                     PFLIRRMEDHSTVGALPEARDRFSFLLDRPRTGDPVPLGRVRSTLRTQDADLRADLYAA
                     VSGVLDCGLDVLVVDQTMPELRRNGLHCVRVLVPGLIPMTFGHRNRRTRGLPRLTEGTT
                     LPYRSLLAPGREIGAVPHPFP"
     gene            complement(20960..22927)
                     /locus_tag="IE308_RS32350"
                     /old_locus_tag="GCM10018783_65530"
     CDS             complement(20960..22927)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS32350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_65530"
                     /product="hypothetical protein"
                     /protein_id="WP_190220611.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 5.4e-29,
                     bitscore: 94.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     4.2e-12, bitscore: 40.4, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MAADRAQPAGPAADPLTDTLTRTYRLRADAFYVRQQDGVWLGNNT
                     GSFSVRGQGAYQLVSSLFAGLDGERTLQDLYGDLPDRARRSVLGLVRAMLRNGFIKEVA
                     HPVEPVPGWMRERYATHLAFLEHHADRPVTRLQQVRTARVVCAGRGTALHALLDALREF
                     GIARLDVVPDGDDDLTAVQQVLKETAAADPGARWRLRDPLAADGPAALAGHPDVEGADA
                     VLLAYDSADAAALARAQHALWRAGVTVGVLARCGDFVTALEPGLGTPYCWECVHRSIAV
                     RATGDTAGLAPAVAPAAVGALRVAQHTFARLAGVRPPGDKPVTTVEPLVPAVRGHAARR
                     HPRCPHHEPAVPRQLPPAGAAAPEDAVRPDIPRSEDPPERVRISDRIVAACAALTDAVT
                     GPLLALGEEDLAQLPLSASACQVADPDGGAHAPAALGVVCRALSPREARNQVVLCAVES
                     LAGRLTAGDARYGAVGAGWSLGEARLRARLHAALGRPTPDLHWAPAPEEPPPGDTAAGY
                     LAGVLAAEGTPWTATAVEELPDGVVRAHVRTRDGAVTAGVGTDRERAVGHALLNAVARV
                     LPLPGNAQEATAFLAPATATWTAAPTAEGEREITGLLPFLTDTDTDTDTDTDTDTGTRS
                     GGEAGARVRVVALPVSEEAS"
     aSDomain        complement(22616..22858)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE308_RS32350_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.00E-13"
                     /identifier="RREFam011.1"
                     /label="IE308_RS32350"
                     /locus_tag="IE308_RS32350"
                     /protein_end="104"
                     /protein_start="23"
                     /score="40.4"
                     /tool="antismash"
                     /translation="YRLRADAFYVRQQDGVWLGNNTGSFSVRGQGAYQLVSSLFAGLDG
                     ERTLQDLYGDLPDRARRSVLGLVRAMLRNGFIKEVA"
     aSDomain        complement(22622..22867)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE308_RS32350_Thiopeptide_F_RRE.1"
                     /evalue="3.90E-30"
                     /identifier="RREFam004.1"
                     /label="IE308_RS32350"
                     /locus_tag="IE308_RS32350"
                     /protein_end="102"
                     /protein_start="20"
                     /score="94.7"
                     /tool="antismash"
                     /translation="TRTYRLRADAFYVRQQDGVWLGNNTGSFSVRGQGAYQLVSSLFAG
                     LDGERTLQDLYGDLPDRARRSVLGLVRAMLRNGFIKE"
     gene            complement(22938..24263)
                     /locus_tag="IE308_RS32355"
                     /old_locus_tag="GCM10018783_65540"
     CDS             complement(22938..24263)
                     /NRPS_PKS="Domain: AMP-binding (113-353). E-value: 2e-26.
                     Score: 84.4. Matches aSDomain:
                     nrpspksdomains_IE308_RS32355_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="IE308_RS32355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65540"
                     /product="AMP-binding protein"
                     /protein_id="WP_190220612.1"
                     /sec_met_domain="AMP-binding (E-value: 6.9e-26, bitscore:
                     85.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRPAFQRFLTPRHLPAGRACAVTGVRWGGDFAAWDDLLTAGRDL
                     AAQVRPGGAYAIDPTAGLPALAALFAVATVPDTVLLWASPRTLGVTGREIAPALHALPD
                     DGSVPLAAQERPLWGVCTSGSSGAPKVAVGPADEWEQIALHAEAAMYADAFPAGPPEAL
                     ATCLPLGFSAAFFMCVLPALYLKRDLVVHPPHDWSPLYDLARDRRVLALGVPALAAAAC
                     LSAPAATDLGSVALFLGGGHLSAPRVELIRRHFTGAAVSNLYGTAETGAIALDHDPGHN
                     RHVGRPIPGKSVWLTGTDERGIGTVAVAGPGCCRRTWRPGSPPSAPADHVTGTDYGRFD
                     ADGNLCLEGRLDGAEKLAGVLVRPREIERHVLALDGVSDVRVTVETAPTGLEFLAATVV
                     GSVDADTVRAHCAALPEQHRPSRISCASEQEAATVYSAHGKL"
     aSDomain        complement(23205..23924)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS32355_AMP-binding.1"
                     /evalue="2.00E-26"
                     /label="IE308_RS32355_AMP-binding.1"
                     /locus_tag="IE308_RS32355"
                     /protein_end="353"
                     /protein_start="113"
                     /score="84.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ERPLWGVCTSGSSGAPKVAVGPADEWEQIALHAEAAMYADAFPAG
                     PPEALATCLPLGFSAAFFMCVLPALYLKRDLVVHPPHDWSPLYDLARDRRVLALGVPAL
                     AAAACLSAPAATDLGSVALFLGGGHLSAPRVELIRRHFTGAAVSNLYGTAETGAIALDH
                     DPGHNRHVGRPIPGKSVWLTGTDERGIGTVAVAGPGCCRRTWRPGSPPSAPADHVTGTD
                     YGRFDADGNLCLEGRLDG"
     gene            complement(24233..24472)
                     /locus_tag="IE308_RS32360"
                     /old_locus_tag="GCM10018783_65550"
     CDS             complement(24233..24472)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS32360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_65550"
                     /product="hypothetical protein"
                     /protein_id="WP_190220613.1"
                     /transl_table=11
                     /translation="MTSQRTTPRTPDDVPDLQEELAGLLQEDDPRRRLDSLETVVVLSY
                     FARQAPGRTLPELPDAPRTIEGWVTWADQRSSAS"
     gene            complement(24469..25263)
                     /locus_tag="IE308_RS32365"
                     /old_locus_tag="GCM10018783_65560"
     CDS             complement(24469..25263)
                     /NRPS_PKS="Domain: Abhydrolase_1 (23-215). E-value:
                     9.1e-13. Score: 40.3. Matches aSDomain:
                     nrpspksdomains_IE308_RS32365_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="IE308_RS32365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65560"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_190220614.1"
                     /sec_met_domain="PF00561 (E-value: 3.3e-09, bitscore: 31.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3e-15, bitscore:
                     52.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTETPRDTETPMHTGTSTGPETPTVYLVHGLLGTGHGHFAAQIR
                     AWHGRLRTVPVDLPGHGRCRRDAAEDYFDDALRYLVAVLERFGPGRLIGASYLGGPLAH
                     RCAATRPDLVASLVLTGFAPDVSRDAFLSLIAGFEGLAAQQPALAAEYEQLHGTRWKRT
                     LDAVTGHVERDFERTALVRAADVAALTVPTLVLNGSLKSVERAAAEQAPGWGGRVRGRV
                     VPGAGHLVGHDRPREFNEAVEDFWRTAHDAPAGPRTTQKGDT"
     aSDomain        complement(24619..25194)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS32365_Abhydrolase_1.1"
                     /evalue="9.10E-13"
                     /label="IE308_RS32365_Abhydrolase_1.1"
                     /locus_tag="IE308_RS32365"
                     /protein_end="215"
                     /protein_start="23"
                     /score="40.3"
                     /tool="antismash"
                     /translation="PTVYLVHGLLGTGHGHFAAQIRAWHGRLRTVPVDLPGHGRCRRDA
                     AEDYFDDALRYLVAVLERFGPGRLIGASYLGGPLAHRCAATRPDLVASLVLTGFAPDVS
                     RDAFLSLIAGFEGLAAQQPALAAEYEQLHGTRWKRTLDAVTGHVERDFERTALVRAADV
                     AALTVPTLVLNGSLKSVERAAAEQAPGWG"
     gene            complement(25289..26491)
                     /gene="nocL"
                     /locus_tag="IE308_RS32370"
                     /old_locus_tag="GCM10018783_65570"
     CDS             complement(25289..26491)
                     /codon_start=1
                     /gene="nocL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF06968"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04158.1"
                     /locus_tag="IE308_RS32370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65570"
                     /product="3-methyl-2-indolic acid synthase"
                     /protein_id="WP_110629796.1"
                     /sec_met_domain="PF06968 (E-value: 9.8e-08, bitscore: 26.7,
                     seeds: 824, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQNSQAMTSHAMTGDFVLPELEDVRAEAATVDTRAVLALAEGEE
                     PAESRAAVALALWEDRSIGTAELQAAAEARCGARRPRLHTFVPLYTTNYCDSECKMCSM
                     RKGNHRLDRKFSGRKEITEQLEILYHHEGVRGVGFLTGEYEDKHTRLASAFRIGWAIRT
                     ALDLGFERVYFNIGSMEQDEIDVLGEWIGREDPVTMCVFQESYDRETYRRFMGKTSVGV
                     PKADFDRRVVSFDRWLDAGYRYVNPGVLVGLHDDLSAELVSLVAHGDHLRSRGATADLS
                     VPRMRPAMKSRDTTRVGDDDYLRLMSVVAFTCPEQRLVLTTREPQEFQDVALGLAGVIS
                     PGSPDVAPYRAGCEARNDEKSSQFLVADLRRPRHILGRIEASGTPVDHFVNPAGEASRA
                     V"
     misc_feature    complement(26805..26821)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.25"
                     /tool="antismash"
     gene            26843..26995
                     /locus_tag="IE308_RS32375"
                     /old_locus_tag="GCM10018783_65580"
     CDS             26843..26995
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: thiostrepton"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03892.1"
                     /locus_tag="IE308_RS32375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65580"
                     /product="thiocillin/thiostrepton family thiazolyl peptide"
                     /protein_id="WP_162655577.1"
                     /sec_met_domain="thiostrepton (E-value: 2.3e-14, bitscore:
                     47.9, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAAHLSDLDIDALEISEFLDESRLEDSEVVAKVMSASCTTCECC
                     CSCSS"
     CDS_motif       26843..26953
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MDAAHLSDLDIDALEISEFLDESRLEDSEVVAKVMSA"
                     /locus_tag="IE308_RS32375_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       26954..26995
                     /prepeptide="core"
                     /locus_tag="IE308_RS32375_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type I"
                     /score="10.70"
                     /molecular_weight="1316.5"
                     /monoisotopic_mass="1315.3"
                     /core_sequence="SCTTCECCCSCSS"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MDAAHLSDLDIDALEISEFLDESRLEDSEVVAKVMSA"
                     /leader_location="[26842:26953](+)"
                     /alternative_weights="1334.5"
                     /alternative_weights="1352.5"
                     /alternative_weights="1370.6"
                     /alternative_weights="1388.6"
                     /alternative_weights="1406.6"
                     /alternative_weights="1424.6"
     gene            27066..28253
                     /locus_tag="IE308_RS32380"
                     /old_locus_tag="GCM10018783_65590"
     CDS             27066..28253
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="IE308_RS32380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65590"
                     /product="radical SAM protein"
                     /protein_id="WP_190220615.1"
                     /sec_met_domain="PF04055 (E-value: 1.9e-17, bitscore: 58.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQNLLMIYVHIPFCHSKCTFCDWVQAIPTKDLLRKPGDSVRQKY
                     ISALCAEIAERGAMHRAAGDIPHVLYWGGGTASSLDEQETAAVMEALHSSFDMSTVAEA
                     TIECSPDTVDERKLSFYRGLGFNRVSSGVQSFDDDRLRRLGRRHTAEQAGRIVHAARAA
                     GFEDVSIDIMSGFPDQEADELDRTVDRALELPVNHLSLYSFRPTPGTFMRRRMDSSERR
                     TYLRRQQALFTRARRAIEGFGLSEYANGYFGKVSPFASMYFQHRADTVGLGSGAISLVD
                     QRFKSHQKGLLHSYVDDPHAFDIDVPAGQDRVLVSLLQAGLAMFDGIPREDWRQRTGTD
                     LAEVLLRPTVAPLADFLRGRGLVEDDHGIRLPRDIAGLTLIELAFEMAMSQPELV"
     gene            28250..29362
                     /locus_tag="IE308_RS32385"
                     /old_locus_tag="GCM10018783_65600"
     CDS             28250..29362
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS32385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_65600"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_190220616.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-10, bitscore:
                     36.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSGPGQAPAEAAHAAGAAWLEIGLDAPADAVPALVAGVVRPLLR
                     EPAEPGAEPAPGFFLRGVGAAQPALVVQLEVTPGTDLAEPYAARARALAAGLGLPVQVA
                     AGPATLVPLAGSVFAGAALGPVTRAALAAVCPALLAATEAAEQGRPALLASAVELMSAH
                     LRAVSVSAAPGPRQWEELREGVPLGFLSYRSHAEAFLASSRDPKAAQAMMDAKYTRAAA
                     TLERLVDGVLTQCEERGPVVSLPARQWYEAMRAAKPAVTELFRAGTDLALDTEEQPPDT
                     GPDGKGLSESAFHRIVEGSDGLRDFLDRDPSFLATRLLTSLLYLSLSSVGIALAERYFL
                     CYAVSRACESIFDTDALTVLSGLARTSLAS"
     misc_feature    complement(29555..29569)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    29825..29838
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            29828..30643
                     /locus_tag="IE308_RS32390"
                     /old_locus_tag="GCM10018783_65610"
     CDS             29828..30643
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358463.1"
                     /locus_tag="IE308_RS32390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65610"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_110629792.1"
                     /transl_table=11
                     /translation="MEIDVLGPLEVSQKSASIVPTASKPRTVLAMLAVYTNRLVPLPSL
                     MGELWGPEPPATAKTAVQGYILHLRKRIAESAARRPPGQFPEAKDILVTLPGGYLLRAP
                     GTAVVLEQFEQLACAGHRAREKGDFEAASRSFTEALGLWRGRALADVEVGPQLGIEVQR
                     IEEARLNVLDRRIEADLRLGRHHELLGELRSVTAHHPTHEGFCAHLMLALYRSGRRCEA
                     LDAYQRMRTTLVNELGLEPSPSLRRLQRSLLVSDRELDELNVTWDVATF"
     gene            complement(30717..34616)
                     /locus_tag="IE308_RS32395"
                     /old_locus_tag="GCM10018783_65620"
     CDS             complement(30717..34616)
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986334.1"
                     /locus_tag="IE308_RS32395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65620"
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="WP_190220617.1"
                     /transl_table=11
                     /translation="MLDVNFFDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDG
                     LFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHI
                     WYFKGVPSRLGYLLDLAPKDLEKVIYFAAYMITYVDEERRTRDLPSLEAHVSVERQQIE
                     NRRDADLEARAKKLEADLAELEAEGAKADVRRKVREGAEREMKQLRDRAQREIDRLDEV
                     WTRFKNLKVQDLEGDELLYRELRDRFGTYFDGSMGAAALQKRLESFDLEEEAEKLREII
                     RTGKGQKKTRALKRLKVVSAFLQTSNSPKGMVLDCVPVIPPDLRPMVQLDGGRFATSDL
                     NDLYRRVINRNNRLKRLLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPL
                     KSLSDMLKGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFVMK
                     RLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPQLV
                     EGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILKPADGRPVTM
                     PTQDMVLGLFFLTTDAEGRGAKGEDRAFASVAEAIMAFDAGELSLQAPVHIRFPVGTIP
                     PRGWVPPVREEGEPEWQQGDSFTLKTTLGRALFNELLPEDYPFVDYEVGKKQLSEIVND
                     LAERYPKVIVAATLDNLKASGFYWATRSGVTVAISDVVVPEAKKEIVKGYEAQDEKVQK
                     QYERGLITKDERTQELIAIWTKATNEVAEAMNDNFPKTNPIFMMVNSGARGNMMQMRQI
                     AGMRGLVSNAKNETIPRPIKASFREGLSVLEYFISTHGARKGLADTALRTADSGYLTRR
                     LVDVSQDVIIREEDCGTDRGLKLKIAERGADGVLRKADDVETSVYARCLAEDIVVDGQV
                     LAPAGTDLGDVLIEELVQRGVEEVKTRSVLTCESAVGTCAMCYGRSLATGKLVDIGEAV
                     GIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEASGRV
                     RIEETEKTKKIVITPDDGSDETAYPISKRARLLVSEGEHVEVGQKLTVGATNPHDVLRI
                     LGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDAELLPGELVER
                     SKFEHENRRVVQEGGHPASGRPQLMGITKASLATESWLSAASFQETTRVLTDAAINAKS
                     DSLIGLKENVIIGKLIPAGTGLSRYRNIRVEPTEEAKAAMYSAVGYDDIDYSPFGTGSG
                     QAVPLEDYDYGPYNQ"
     gene            complement(34724..38209)
                     /gene="rpoB"
                     /locus_tag="IE308_RS32400"
                     /old_locus_tag="GCM10018783_65630"
     CDS             complement(34724..38209)
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rpoB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_037647936.1"
                     /locus_tag="IE308_RS32400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65630"
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="WP_110629790.1"
                     /transl_table=11
                     /translation="MAASRTASTANTNNGASTAPLRISFAKIKEPLEVPNLLALQTESF
                     DWLLGNTAWQSRVEEALENGQDVPTKSGLEEIFEEISPIEDFSGSMSLTFRDHRFEPPK
                     NSIDECKERDFTYAAPLFVTAEFTNNETGEIKSQTVFMGDFPLMTNKGTFVINGTERVV
                     VSQLVRSPGVYFDSSIDKTSDKDIFSAKIIPSRGAWLEMEIDKRDMVGVRIDRKRKQSV
                     TVLLKALGWTTEQILEEFGEYESMRATLEKDHTQGQDDALLDIYRKLRPGEPPTREAAQ
                     TLLENLYFNPKRYDLAKVGRYKVNKKLGTDTPLDAGILTVEDIIATIKYLVKLHAGETE
                     TVGDNGQPVVVETDDIDHFGNRRLRSVGELIQNQVRTGLARMERVVRERMTTQDVEAIT
                     PQTLINIRPVVASIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGFEV
                     RDVHPSHYGRMCPIETPEGPNIGLIGSLATYGRVNAFGFVETPYRKVVDGQVTDEVNYL
                     TADEEDRFVIAQANAPLTADMRFEEARVLVRRRGGEVDYVAPEDVDYMDVSPRQMVSVA
                     TAMIPFLEHDDANRALMGANMMRQAVPLIKSEAPLVGTGMEYRSAVDAGDVVKAEKDGV
                     VQEVSADYITTANDDGTYITYRLAKFSRSNQGTSVNQKVIVNEGDRVITGQVLADGPAT
                     QNGEMALGKNLLVAFMPWEGHNYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPE
                     EITRDIPNVSEEVLADLDERGIIRIGAEVIAGDILVGKVTPKGETELTPEERLLRAIFG
                     EKAREVRDTSLKVPHGETGKVIGVRVFDREEGDELPPGVNQLVRVYVAQKRKITDGDKL
                     AGRHGNKGVISKILPIEDMPFLEDGTPVDIILNPLGVPSRMNPGQVLEIHLGWLASRGW
                     DVSGLADEWAQRLQAIGADKVEPGTNVATPVFDGAREDELAGLLQHTIPNRDGERMVLP
                     SGKARLFDGRSGEPFPDPISVGYMYILKLHHLVDDKLHARSTGPYSMITQQPLGGKAQF
                     GGQRFGEMEVWALEAYGAAYALQELLTIKSDDVTGRVKVYEAIVKGENIPEPGIPESFK
                     VLIKEMQSLCLNVEVLSSDGMSIEMRDTDEDVFRAAEELGIDLSRREPSSVEEV"
     gene            complement(38748..39137)
                     /gene="rplL"
                     /locus_tag="IE308_RS32405"
                     /old_locus_tag="GCM10018783_65640"
     CDS             complement(38748..39137)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006130601.1"
                     /locus_tag="IE308_RS32405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_65640"
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="WP_110629789.1"
                     /transl_table=11
                     /translation="MAKLTQDELLAQFEEMTLIELSEFVKAFEEKFDVTAAAAAPVVVA
                     GGAAGGAAAEAEEEKDEFDVILTGAGDKKIQVIKVVRELTSLGLKEAKDLVDGTPKPVL
                     EKVNKEQADKAAEALKGAGASVEVK"
ORIGIN
        1 tgcagtacgg gtcggagaag atccacgaga agctcgacca ggcgcgggag acggcgagcc
       61 acgtcttcga ccgcctgacg gccaacccgt ttggatgacc accgtggacc acaccccgta
      121 cacgttcctg atctcggcga acaaccccgt gccgctgtcc gggccggtgc cgccgcacct
      181 gccgcccgac gcggagacgc ccgcgacgat ccgccgtacc ggacagcgcc ccgaggagcc
      241 gcccctcgcc cgggtcgtca cgccgcgcct ggaccggcgc tggagccgca aggcacccgt
      301 gccgttctgg atccactccg gcccggacga cgccctgctc tgctccgtcc acccggccgg
      361 cccggacagc tacgaggtcc acgccgccga cggcaccccg ctggcccgcg tcacgcgcca
      421 ccccggccgc ttcctgccgt ggccccgcag ggtccgctgg tcggcggacc ccgcggggtc
      481 gttcgggcag gtcacgggcc gtgagggcac ccggtggggg tggctgacct atgtggtcac
      541 ttccccggtc tggttcctct gggtcgtggg catgaccctg ttctccttct tcgacggcag
      601 ccccgacgac ttcaccttcg gccgcccgtc ccgcacccgc tggcacgccc ccggcacggg
      661 cacggtcctg gactaccggg gccggcggaa gacctgccgg cacgaccccg gtcacctgga
      721 ctcccgcacg gcctacgccc tggcggtgct gcggacctgg tccgcgtcac gctgaggtca
      781 gcgccggccc tgccgcagct cctgccgcag cgcctcgtac gccggcttcc ggcggtacga
      841 ctcgtcgtac aggcaggccg cgccctcgcc gtcgaagacg tcggggaccc aggagtactg
      901 gtcggcgaag ccccacaccg tgaaggacgt gcagctcgtc gagccgaggc aggccgacag
      961 caggccgcgg tagtagtccg cctgcgtggc cagcttcgtc gcgtccgcgg gcagcggtat
     1021 gcggacgtcg acctccgtga acgcggtctg caggccgagg tccgcgaacc gcttcaggtt
     1081 ggcgccgaca tcgcccggga agccgtactg ggtgctgagg tggccctgga tgccgaagcc
     1141 gtcgacgcgg acgccctggg ccttcagctg cttcgccagc tcgtagtagg ccgtggactt
     1201 cgcgttcaca ccctccacgt tgtagtcgtt gaagaacagc ttcaccttcg ggtcggcctc
     1261 gcgggcccag cggaaggcgt cggcgatgta gccggggccg agcttctgca gccagaggga
     1321 gtcgcggtag gtgccgtcgt cgttgaagac ctcgttcacc acgtcccact ggtagagctt
     1381 gcccttgaag tgggtcacca cggtcttgat gtggtcgtgc aggatctcgc ggagttccgc
     1441 ggagtcgatc gtgccgtccg cgacgccctg ggtgagccac ccgggcagct ggttgtgcca
     1501 gagcagcgtg tggccgcgca ccgactggcc gtgggcgcgg gcgaagtcga tcagctggtc
     1561 ggcggccgtc cagtcgtaca cgccccgctg cggctcgacg acctcccact tcatgacgtt
     1621 ctcggcggtc accgagctga actcccggcc ggtgatccgg cggtagtcgg cgtcctccgc
     1681 cagcgcggtg gtgttgaccg ccgtgccgaa cttcaggtgc gcccgctcgg ccgccgccct
     1741 cagcggcatg ccgggggcct gggtgtccga ggcggcggac gccgtctgcg cccccgcccc
     1801 gagcagcagg gcgccggccg cgaggagcgc ggcggaggtg gtgcgaactt gcctcatcgt
     1861 tgtctttccc tttcccatca gtgaatgcgg tggctctcca gcgggcccag gtacgtctcc
     1921 ggcaggccgc ccgtgtcgat cagcagacgc tgtacgacga ccgtcgggtc gaccatccag
     1981 aagcgcagcc ggtgcacgcc ggcctccgcg atccggtggc gcgtggacgt ccggttcacg
     2041 ttgtcggacg tgtggcgttc ccaccggcgg ttcaggcccc cgtcgtccgg gcccgtcacg
     2101 gcgatgacgt ccacggtctg cgggggcgcg tcgtcgaagg agacggcgta gcgcaggccg
     2161 gggcgggcca gggccgggtt gcggggcgag aggtacgccc acacggtgac ctcgcccggc
     2221 gtcagcagcg tcacgtcgta ctccaggcgc ggcccgttcc cgcccggcgt ctgcgccggc
     2281 gccgtcaccg gcaccggggt catgcccgcg ccggtacggc cgaggcggtc gacgcgcagc
     2341 cagccgatgt cgcgggtgcc gacggcgcgc gtgtagtgct cggcgtcgat ggcgacgtag
     2401 ccgccggcct cgacgaagcc cttcagtccg cgcggggaga gcggggaggc cacggcccgt
     2461 acggtcacgg tgcggcccgc gccctcgacg gtcagctgcc cctcggcccg cccggccggc
     2521 accttcgccc agtcgaccgt cacggccacc cgggtctgct gccgtaccgt cccgcgcggc
     2581 cggtccacgc gcagccacgg caccgaggcg gtgatccggt acgggaacgc gcgcgtgccc
     2641 cggttgaaga tctccacgta cgtccccgtg gggtccgtgc ggtacgggct gaactccggc
     2701 agcaccgggc ccggctcccc gctccccggc caccagtcct ccgagccggt cacggcgacg
     2761 cccatctccg ccacgtccgg cacctcgatg cgccggaccg ccgggaagag gacgtcgggg
     2821 atggccacgt tgtcccgctc gggctgctgc cagggggcgt tggggccgta ccgttccacg
     2881 tcgccgtagt cgatgtgcgg ctggagctgg aagtcctgcc acttgccgcc ggcgatctcc
     2941 tggttgaaga cgtcctggag gcggaagtcc tccgcgaggc ccgcctcggc cttcgcggcg
     3001 aggtcgttgg tggcggcgcg gccctggcgg gcgtagagga ggttggtgaa ctcggcctcg
     3061 cgcagctcgt agaggttggc ggtggcctgg atgttgtagc cgaccagttc gaaccaggcg
     3121 tccgaggcgg atgcgggaag gtcgcgggcc acgcgggccg cgtccttgcc gagccgccgc
     3181 caatcctccg tgacgcgctc caactcgccc cagtagaagg gggtctgctg gtcgtcgtag
     3241 aggacggccg agtcgtccgt cgccaggtcc ttggtggggt ccagagtgat acggcggttc
     3301 agcagctccg gcttgcggcg gtgctggaga tggccgtagc gggcgaggag gccggcgatc
     3361 gcctcggcgt gctcctcgcc gaagtggagg gcggcgtaac ggcgttccca ctcggacagg
     3421 gcgcccaggg tccagcgccc ggggttccag gcgtagtcca tgaagaagtg cgtgggcagc
     3481 tcgttgccct tgaggtcgcc gacgttggtc acccacaggg tggtgttgcc gtaggccacc
     3541 gcctggtgca gctggtccca caggttgggc aggttgaccg tgtcgaccca cttgtagttg
     3601 cggccgtcgc cgacgtagtc gaagtggtag tagaggccgt agccgccctt gcgcggcggt
     3661 tcggcggggt cggggtgcat gcggatgttg ccccagttgt cgtcgcagag gacgacggtg
     3721 acgtcgtcgg gggcgcgcag gccgcgggtc cagtagcgct ggacctcctt gtacagcgtc
     3781 cacacctgcg ggacggacgt ctccgagccg gtgacctcgg cgatgatgcg ccgctgggtg
     3841 gcgatgatct cgtgcatcag ctcgatggcg tcgccgtcgg gcaggctggt gtcgccgttg
     3901 ccgcgcatgc cgagcgtgac gactccctcg atgccctggt cggccatccg gcgcacgccc
     3961 tcgcgccagt acgcctcgat ggcggcgcgg ttgcggcgga aggaccactc gccggtgccg
     4021 ccgtacgggt cgtggccggg ggtgacgatg ttcccggcgg cgtcgcgctt ggcggggacg
     4081 gcgtgccggt tccactcctc gatgccgcgc atcatcgggg cctcgtggga ggtgccgacg
     4141 acgatgccgt actcggtggc gcgggcgtgg ttgtcggggt cgtcctcggc gaaggcgcgg
     4201 ccccagacgg ccggccagag gtagttggcc ttcaggcgca gcagcagttc gaagaccttg
     4261 gcgtagaagt cggcggtgaa gccgccgggg tagccgggtg ccttgccggg accgaagaac
     4321 cgcggggccc aggtgccgag gttggggttc tcgtcgttga tgaagacccc gcggtacctc
     4381 acggtcggcg tgccctgggt ccaggcgccg gggcggacga agatctgccg ccgccggacc
     4441 ggccggacgt cgtcccacca gtgccagggg gagacgccga tgccgcggga gacgtcgtac
     4501 gccccgaaga tcgcgccccg ctggtcgctg ccggcgatga cgaacgcgcg gtcgacgccg
     4561 ggcagcgggt gctcgacgac cgtctgcagc gaggtctccc actttccgcg gatcgcggag
     4621 acgtccagct tccccgccgc gatcaggccg tcgagcaggg ggctgtggcc gaccgtgccg
     4681 acgatcgcga tctcgcgggc gctcccccgc tcggcggccg ggcggacgcc ggtcacgcgc
     4741 tcgatgtcgg cgcgcaggtc ggcggcgacg cggcggacgc cggggtggtc ggcggcgtcg
     4801 acgaggacgg ggaccgcgcg gccggagcgg accaggggga aggcgccggg ctcggggcgg
     4861 aaggtgacgt aggcgccggg gtcggtgggg cgcggagccc tcgtggcggc ctccgcgccc
     4921 cccgcggcct cggcggtgac cggcggcagc gctgctccga gccccgctgc catgccggtc
     4981 ccgaggaccg ttctcctgct gacgtcccgc gtcatacgac accctccctg ccacgcacta
     5041 atttggaaag cggcatgaca aatgctgggg tcgggtgacc ggtgtgaaca atggggcggt
     5101 cggcaacgaa gcggcaacga aacgttgcga cgagggcaca cagagtgacg ggccggacac
     5161 gcgaaaaggg cccgcacgac cgaagtcgta cgggcccctt tcaggagctc acgagggagc
     5221 taccgggtca cgggaccctc aagcaagcgg aacttacttg acgatcttgg tgacctggcc
     5281 ggcgccgacg gtccggccac cctcacggat ggcgaacttc aggccctcct ccatggcgac
     5341 gggctggatc agctcgacgc gcatctcggt gttgtcgccc ggcatgacca tctcggtgcc
     5401 ctcggggagg tgcacgacgc cggtcacgtc cgtggtacgg aagtagaact gcgggcggta
     5461 gttgttgaag aacggggtgt gacggccacc ctcgtccttc gacaggatgt aggcctgggc
     5521 ctcgaactcg gtgtgcggcg tgaccgaacc cggcttgatg atgacctggc cgcgctcgac
     5581 gtcctcgcgc ttgatgccac ggaggagcag accgacgttc tcaccggcct ggccctcgtc
     5641 gagcagcttg cggaacatct cgatgccggt gaccgtggtg gtggtcttct cggtcttgat
     5701 gccgatgatg tcgacggtct cgttgacctt gaggacacca cgctcgatac ggccggtgac
     5761 gaccgtaccg cgaccggtga tcgtgaagac gtcctcgatc ggcatcagga acggcttgtc
     5821 gacgtcacgc tcgggctccg ggatggactc gtcgacggcc ttcatcaggt cgaggacgga
     5881 ctgcgtccac tgagcgtcgc cctcgagcgc cttcagcgcc gagacgcgga cgaccggcag
     5941 gtcgtcgccc gggaactcgt actcggagag gagctcacgg acctcgagct cgacgagctc
     6001 catgatctcc tcgtcgtcca ccatgtcggc cttgttcagg gcgacgacga tgtacggaac
     6061 gccgacctgg cgggccagga gcacgtgctc cttggtctgc ggcatcgggc cgtcggtggc
     6121 ggcgaccacg aggatggcgc cgtccatctg cgccgcaccc gtgatcatgt tcttgatgta
     6181 gtccgcgtga cccgggcagt cgacgtgggc gtagtgacgc gcctcggtct ggtactcgac
     6241 gtgcgcgatg gagatggtga taccgcgctg acgctcctcg ggcgccttgt cgatgttgtc
     6301 gaacggggtg gcctcgttca ggtccgggta cgcgtcgtgc agcaccttgg taatggcggc
     6361 cgtgagggtc gtcttaccgt ggtcgatgtg accgatggtg ccgatgttga cgtgcggctt
     6421 agtccgctcg aacttcgcct tcgccactgg ggtcctcctg tggagtggtt ctgtacgcct
     6481 tacttcatcg gcgccaggtg atctttgctg taaaggcccg gaacccgggg caaacgctca
     6541 cgattgcggg cgtttacccc ttgaggctcc ggagtcaagc ctacggcgtg ggaacgcggt
     6601 gcgttactcg cccttggcct tcgcgatgat ctcctcggcg acgttccgcg gaacctcggc
     6661 gtaggagtgg aactgcatcg agtagcttgc gcgacccgac gtcttgctgc ggaggtcgcc
     6721 gacgtagccg aacatctccg acaggggcac gaggcccttc acgacgcggg caccggcccg
     6781 ctcctccatg gcctcgatca tgccacggcg ggagttgatg tcgccgatca cgtcgcccat
     6841 gtagtcctcg ggcgtggtga cctcgacggc catcatcggc tcgaggagca cggggctggc
     6901 cttgcgcgcg gcctccttga aggcctgcga accggcgatc ttgaacgcga gctcggagga
     6961 gtcgacctcg tggtaggcac cgtcgagcag cgtgacacgc acaccggtca tctcgtagcc
     7021 ggcgaggatg ccgaactgca tggcctcctg gcaaccggcg tcgaccgagg ggatgtactc
     7081 cttcgggata cgtccaccag tgacctggtt gacgaactcg taggacatgt cgccaccctc
     7141 gatcggctcg accgagatga tgacgcggcc gaactggccc gtaccaccgg tctgcttctt
     7201 gtgggtgtac tcgaccttct cgaccgactt gcggatggtc tcgcggtacg cgacctgcgg
     7261 cttgccgacg ttggcctcga ccttgaactc gcgcttcatg cggtcgacga gcacctcgag
     7321 gtgcagctcg cccataccgc cgatgacggt ctggccggtc tcctcgttgg tgtggacctg
     7381 gaaggagggg tcctcctccg cgagacgctg gatggcgaca cccagcttct cctggtcgcc
     7441 cttcgacttc ggctcgatcg cgacctcgat gaccggcgcc gggaagtcca tggactccag
     7501 gaccaccggg gacttgtcgt cgcagagcgt ctcaccggtg gtggtctgct tcagacccat
     7561 gacggcgacg atgtcgccgg cgcccaccga cgcgatctcc tcacgcttgt tcgcgtgcat
     7621 gcggtagatc ttgccgatgc gctccttgcg gcccttgacg gagttcagca cggcggtgcc
     7681 ggactccagg cggccggagt acacgcggac gaaggtgagc ttgccgaggt gcgggtcgct
     7741 catgatcttg aacgccagcg ccgcgagggg ctcctcgtcg gacggcttgc gcttgatgac
     7801 ctcttcggcg ttgtcgaccg cgtggccctc gatggcctcg atgtcgaccg gggagggcag
     7861 gtagcgcacg accgcgtcga gcaggggctg gacgcccttg ttcttgaacg cggtgccgca
     7921 gaagaccggg gtcaccgtgg tgccctggcc cttgccggaa gcgatcgtga tacggcggat
     7981 ggccgcgtac agctgctcct cggagggctc ctcgccctcc aggtacagct ccatgatctc
     8041 ttcgtcgttc tcggcgacgg cctcgagcag cttgccgcgc cactcctcgg cggcctcggt
     8101 gtgcgtggcc gggatgtcga cgacgtcgta catctcgccc ttggtcgcct cggcggacca
     8161 cacgagcgcc ttcatgcgga ccaggtccac gacgcccttg aagtcggcct ccgcgccgat
     8221 cggcagctgc atcacgatcg gctgggcacc cagccggtcg ctgatcatgt cgacgcagcg
     8281 gtggaactcg gcaccggtgc ggtcgagctt gttgacgaag cagatacgcg gaacgccgta
     8341 gcggtccgcc tgacgccaca ccgtctcgga ctgcggctcg acgccggcga cgccgtcgaa
     8401 caccgtcacg gcaccgtcga gcacgcgcag ggaacgctcc acctcgacgg tgaagtcgac
     8461 gtgacccggc gtgtcgatga tgttgatggt gtggtcgacg tcgtccagcg accagtgaca
     8521 ggtggtggca gcagaggtga tcgtgatgcc acgctcctgc tcctgctcca tccagtccat
     8581 ggtggcagcg ccgtcgtgga cctcaccgat cttgtaggac acaccggtgt agaacaggat
     8641 ccgctcggtg gtggtcgtct tgcccgcgtc gatgtgggcc atgatgccga tgttgcgcac
     8701 cttggccagg tcaagcgaag tggtagccat aaggcttcag tcttctctcg gttctcgaag
     8761 gggttccgac taccagcggt agtgcgcgaa ggccttgttg gactcggcca tcttgtgcgt
     8821 gtcctcgcgc ttcttcaccg cggcgccgag gccgttggag gcgtcgagga gctcgttgag
     8881 cagacgctcg gtcatggtct tctcgcgacg ggcgcgggag taaccgacga gccagcgcag
     8941 cgccagggtg ttggcacggc cgggcttgac ctcgaccggg acctggtagg tggcgccacc
     9001 gacacggcgg gacttgacct cgagggtcgg cttgatgttc tcgagagcgc gcttgagcgt
     9061 gatgaccggg tcgttgccgg tcttctcgcg caggccctcc atggcgccgt agacgatgcg
     9121 ctcggcggtg gagcgcttgc cgttcagcag caccttgttg atcagggagg tcaccagagg
     9181 agaaccgtag accgggtcga tgatgaccgg gcgcttcggg gcggggccct tacgaggcat
     9241 tcttacttct ccttcttggc gccgtagcgg ctgcgggcct gcttgcggtt cttgacaccc
     9301 tgggtgtcga gcgagccacg gatgatcttg tagcgaacac ccggcaggtc cttcacacgg
     9361 ccgccgcgca cgagcacgat ggagtgctcc tgcaggttgt gtccctcacc cggaatgtaa
     9421 gcggtgacct cgatcccgct ggtcagacgc acacgcgcga ccttacgcag ggccgagttc
     9481 ggcttcttcg gggtggtcgt gaacacacgc gtgcagacgc cacgacgctg aggggaaccc
     9541 tcgagtgcgg gcgtcttgtt cttctcgacc ttgtcctgcc ggcccttgcg gaccagctgc
     9601 tggatcgtag gcactacttc tccggtttct gtgtgccgaa tggtgaagct aacctggaac
     9661 gtcgccgacc cacgcggtcg ggtgtgtcga atcgtgcgga ctcccgccgc aaggcagaaa
     9721 gaggcgcaga ttgcggtggc cggtgacggc tctctgtgcg gttgaaggca cgcacgagag
     9781 ccagggcaca ccccaggcac aaggtctgag cgtacctagc ccgtcagctc cggtcaaaac
     9841 aaatggaacc cgccccggtg gaccggggcc gcgagcgcac cgcgtaccga ttcatcccgg
     9901 tacgtacggt acccgggcat ggccggagca tgcccgggta ccggggggcg cgcgaggggc
     9961 gcgcagaagg cgctgatttt tggtggtgtc tccgctcgcg ctacgccggc ggccgggcgg
    10021 ggatgaaggc gtcggcgccc ggcggtacga actcctgcgg gcgggtcagc ggctcgggcg
    10081 aggccgggtc gaaggccagg cccagcccct tgccgaaggg tgcggcggca gcggcggggc
    10141 cctcggtggc ggcctcgacg ctgtagtagc ggcgctcggt cgggcggtag ccgatcagct
    10201 ccacgacctt ggacacgccg ggcgggcggc cgtaggcggc ctcgggcgag tcccagaggt
    10261 agaccgcgcc ccactgctcg ccctcggggc cggtggagga gatccacgtc ttctgccgca
    10321 ggccgggcac ggtcgcgtac gcgtccacgg cgtggtcgcg caggtaggcg cgcagggagg
    10381 cgacggtcgc cgcggagcgg gacaggtccc acaggacgac cgtgcagtac agctgctgtg
    10441 cggggtgttc ggtcatcgca ggaccgcctt cagttcgcgc gggtaccggt ggaagaggtt
    10501 cgcggtgaac tccacggcgg ccgggtcggc ggccggggtg agggcgggga agcggcgcag
    10561 cagccggccg aggccctcct ggagttccac gcgggccagg gacgagccga ggcagtagtg
    10621 cgcgccggcg ccgaaggtga ggtgggtgcg cgcggcgccc cgggccaggt cgaaggtgtc
    10681 ggggcggtcg acgtgccgct cgtcgcgggc ggcggagtcg agggagatga agaccgtggc
    10741 gccctcgggg agggtgatgc cgccgagggt cacctcctcg gtggtgacgg tcgtcccggc
    10801 gaagccggtg ccggcctggg cgtaccgcag gatctcctcg acggcggcgg cctcggtgac
    10861 ggtgccgtcg cgcagccggg cgagctggtc ggggtgctgg aagagggcga ggagtccgtt
    10921 ggcgaactgg acggcggtgg actcgtaacc ggcggtggcc agcaggacga cggtggagac
    10981 gagttcgtcg gcggaggggc gggcgtcctc gtcgaggccc gcgatcaggc tgccgatcag
    11041 cccgtcgccg ggagcggcca gctccttctc caccagctgc cgggccacgc cgaacagcgc
    11101 gcccatggcc gcgccgaagg cggcggtcga cggggcggcg gcccgcacct gggccgccca
    11161 cccccacagc ccggggcgca gctcttcggg caggtcgaac agctcgcaca gcacgcggac
    11221 gggcacctgg taggcgaagc cggagaccag gtcgacgggt tccggccccg cctcggcgag
    11281 cccgtccagc acctcgtcca ccgcctgccc gaccgccttg cgcagcgact cggcgtgccg
    11341 gggggtgagg acggtggcga gggtacggcg ccaccgggcg tgccgctcgg gatcggccag
    11401 cgccatcccg aagtcgaacc gctgcccggg ccccttaccg ggggcccccg agcccacccc
    11461 gcccggcacg gcaccgaacc cggctccgcc cgggccgcca ggcccgccgc cttgcggcag
    11521 ccccgccccg gggccacccg caccgccagg cccgggcgcc ccacccggcc aaccgccctg
    11581 cggcgctccc ccggccggtc cacccggacc gccaggcccg ggcgctccac ccggccaacc
    11641 gccctgcgga gacaccccgg cggggccacc cggaccgtcg ccctgcggga caacccgggc
    11701 gggcccgccc ggttcgccat cctgcggcag tcccgccccg gggccacccg ggccgccagg
    11761 tccgggcgcc ccacccggcc gaccgccctg cggggcaccc ccgacggggc caccctggcc
    11821 gtcgccctga ggggccaccc ctccggggcc gcccggccaa ccgccctgcg gtgctccccc
    11881 tgccggtcca cccggaccgc caggcccggg cgccccaccc ggccaaccgc cctgcggggc
    11941 acccccggcg gagccgcccg gcccgcccgg ccaaccgccc tgcggggcac cctcagcgga
    12001 gccgccgggg ccgggcgggc cgccccggag ggctcccgct cggatcgccg cgcggctgaa
    12061 gcgggggtcg gtcaggaccg tgcggacgtc gtcgtggcgg gtgaccagcc aggccgtggc
    12121 gccgttcgcg aggcggatct gggagacggg ggcctcgtcg cggcggcgga ccagttcctc
    12181 gggtggggcg aaggggcact tctgctcgaa ggggtacgtc gggctctcgt ccatgggggc
    12241 ctccacgctc agatccgcac cggcagctcg gccgggtaga aggtgaacag gttgctggcg
    12301 agcggcacgc cgtccaggtc gggcccgtcg aaccgcaggt ccgggaagcg gttcagcatg
    12361 cgcgcgatgc cctcctgcat ctcgacgcgg gccagcgcgg cgcccaggca gtagtggggg
    12421 ccgtagccga acgcggtctg ccggtgggcg cagccgcggc cgacgtcgaa gcggtcggcg
    12481 tcctcgccga agaccttctc gtcccggttg gccgacgcga gggagacgaa gacggtcgag
    12541 ccggccggga cggtcccgcc ggacagctcg acgtcctcgg tggtgaactt ggcgatggcg
    12601 tacccggtgc ccatctgggc gtaccgcagg atctcctcga cggcctggcc gatcagcgcg
    12661 ggctcctcgc gcagccggcg catctgggag gggtcgcgga acagggcgta gaaggcgttg
    12721 ccgagctgga cggcggtgct ctcgtagccg gccatcagca gcaggatgac cgtggagacc
    12781 agttcctcgt tgctgagccg gccgtcctcc tcgtcggtga ggccgatcag cgtgctgagc
    12841 aggtcgtcgc ccaggttctg ccgcttgcgg acgatcagcc cgatggcgta ccggccgatc
    12901 gcctggaggg cctggccgaa ctcgacgaac gacgaggtga agtcgcggcg ggtgatctgc
    12961 gcggcgagcg cggagaactc ggggcgggcg gtctgctcca gtccgagcag gtcgcagatg
    13021 acccggatcg gcagctggta ggcgtagtcg gccatgaggt cgaagcgacc gccggcgctt
    13081 tcgaggtcgt cgaggagggc gtcggtgtgg gcggcgacgg cgggccgcat cgactcggcg
    13141 tggcgggcgg tgaacgcctg gttgaccagg cggcgccagc gggtgtggcc gggcggttcg
    13201 gagatggagc cgccgaagtt gaagacgggg ctgtcggcgt cggcctggaa gccggtgtcc
    13261 acccgggccg cgccctcccg gttgatggtg cgggagaacc gcgggtcggt gagggcggtg
    13321 cggacgtcct cgtagcgggt gatcagccag gcggtgtcgc cggtggcgag gcggacctgg
    13381 gcgatgggcc ggttctcgcg cagccaggcg aactcctccg gcatctcgaa cggggtgtgg
    13441 cgggtgaagg ggtaggtgcg cgcttcgatg tccacggcag gggctcctgt cggtcagtgc
    13501 tggccggagg gcagatgggc ggcgaggcgt tcccggcggt ggtcgcggac ccggtcgagc
    13561 aggccggtgt ccggggcgag gcccgcgcag tcggcgacga cgtggtggcc gaggtagccg
    13621 aggaaggcct cctgctccgg gatgaggccc agccggttgt tgtgggtgtg cagatagctg
    13681 aggagcacga tctggcggcg ccgctccgcc ggcgcgtcgg ggccgccgag cgtcacggcg
    13741 ggcagcacgc ggtccgcggc cgtgtgcagc gcctgccagg cctctccgac ggcccggccg
    13801 taggggtcgt cgggcggctg cgcggcggcg agcagcggcc gcaggtgggc ggcggccggg
    13861 ccgcggcgct ggtccagcag ctcgggccag gtgtcgagga agctgtcgaa gacgtacggc
    13921 gaccacaccg cgcagtagtg ggcgaggaac gcggccatgg cgggcgggga gagccgggcc
    13981 gcgcacaggc cgcgcagcgt catggtgaac gcggcgccca gccggcgggc cgggcggtcg
    14041 ccgatggcgc gcagcgcgga cagggcgacg gcgctgctgc ggtcgaagaa ccgctcggcg
    14101 acggcgacac cctccgggcc gccgtacttg ccgtactcgg gctcgtagcg ggcggggtgc
    14161 acggtgtccg gcgggagcag ttcgccggtc gcctccgact ccagtgcggc catggtcagc
    14221 tgggcctcgc ggaactcctc ggggtcgagg tctccgtagc cgccggggtg ggcggcgagg
    14281 tggccggcga ggcggtcggc gacctcgcgc acggtgcggg cggcctgctc ggggtcgtgg
    14341 gcggcggggc gcaggcggag ccggatgtgg tggccgccct gccagtaccg caggaagaag
    14401 gagctctcca gcgcgccgga ggcgtgcagc ggggcgagca cgggggccag cccgtccacg
    14461 aggaacgcgt cctgatcggc gtaccggtgc aggtgcaggc tgtgccaggg gccggtctca
    14521 ggggcgggca tgggcgtcct ccgtggcctg ggttccggcg ggggcggggg tgccgagggt
    14581 gtactcgacg aagaactcct ccgcgccgga ggtccggccg tccaggtcgc cggcgtgcgg
    14641 caggcactcc tggaaggtga cggtggcgtc cgggccggcc tcggcgagcc ggcgggcgaa
    14701 gacctggagg aggaaggggt tgcgggcgtc gaggtagtgc ggtttgtgca gccgggcggt
    14761 gcgcgcctcc agcgcccact gccgggtctc cgccagcagg tcgcgctcgc cggcgggcac
    14821 gggcgggggc gtggtcagcc ggaagaaggt gtgccggggg atgccccgct gcccgagcca
    14881 gcggtcgaac gaggcgaggg ccgccgcctc ctgccgttcc aggccgtcgg tgtccgggac
    14941 gtccgccgcg ggcagccgcc aggaggcccg gtcgaggacg aggtcgccga gcagtacccg
    15001 gggcagcgag cggtgggctg cggggacgcc ggtgcggccg gcggcccggc ccgcttccgc
    15061 gtcggcccgg tcgagctggt cccacagtcc gccgcggtag gtgcgggtgg gggcgaaggc
    15121 gcacagcagc cggtacaggc cgggtgcggc ggccgggtag aggaagttga gcggtacgag
    15181 gtccaggggc tgcccgtcgc gggtgctgac cagggtcagc gtgcggcggg ccgggtcggc
    15241 gcggacggcc aggtcggcga gggtcagggc gtgctcgtcg gcggcgcgcg gcaccgagcc
    15301 ggggtagacc agctcgtacg ggctgagccg ggggtgcaga ttgaagttga ggccgaggac
    15361 ggccgtgatg tcgcactggc ggggcgtcgt gcgggcgatg tggccgcgca gcgcctcggt
    15421 gaggctccac tcgtgcggcc cgtccggctc cagcagatcg cagaaccggg agaagaacac
    15481 gccgtgcccg gtggtgacgc cgttgacgac ggcgtacggc cgctcgggtt ccgcggtgaa
    15541 ctgcatccgg taggcggtgg accgccaggg ggtcacctcg gcgggcagcc ggtcggcgaa
    15601 ggcgcgcagc cgctcggcgt ccaggcgcag cgcgccggtg tgtgcgctgt catgagcgcg
    15661 cagttcggtg cggaggaggt cggcgaagtc ggcgcgcagc cggcggatgc ggtcgctgtg
    15721 cgggtcgccg acgccggagg ccacggcact ggcctcggcg ggcggcagcg cggcgaaccg
    15781 gcggtagaac tcgatgaacg ggacgtcgcc gtcgccgtcc gccgcgccga agtgccgggc
    15841 gaagaaggcg tacaggcccg ccttctccac gctcgcgtcg tccagcaccg ggacgatccg
    15901 ctggaacagc tccagggccc agcggttggc gtgcagcagg tccgggtgcc agctgtgggc
    15961 gggttcgcgg gtgccgacgt cctcgtagac gacggagcgc atggcctcgg gggcaggggc
    16021 gcggcagccg acggcctcga cgaacacggc gacctgttca cggatctcgg ccagcagcgc
    16081 ggcccgccgc cgcacggggg cggccgggaa ggcgtcctcg gcggcctgga gccgttcgaa
    16141 gacgacggcg cagcggccgg cctggtcggt gtcgagggtg cgcagccgct gggcgacggc
    16201 gagcgcgggg cgcgggtgct ggtcggggat gccgagcccg cgttcgcaga tcccggcgcg
    16261 gaccagcttg tccagggcgg tcgccgcggc ctgcggggac agtccggcgg cggtcagcct
    16321 ctcgcgcagc tcgcgctcgg gcagcccgcc gtcggcgagc agggaccgca gcaggcgcag
    16381 caggccggtg tcgcgggcgg tcaccacctg ggcggtgccg taggcggcct cgggggcgcc
    16441 gtccggggcc cgccgtacgc acagggcctg ttcctcccgg acgagcaggg agtggttgag
    16501 ccggatccgc atcagctcgt cggcgcggtc caggcggtgc agttcgtacg tcatccagga
    16561 cagcagtccc gcgctgagcc gggcctggac ggggcgggcc ggagggcggt cggccggtgc
    16621 ggccggtgcc gtgccgtcgc cggcgggcgt ccagggggcg gcgccgatct cggtgaagga
    16681 ggcgaacggc gacggcttga gggcgacccg gtaggcgaag ctggtcagcg tgttctcggc
    16741 gcggcgccgc ttgctgggct tgcggcgcgc ggagaacggg tcggcggccc actcggtgac
    16801 ggtccgccag gtccgctcgt cggacagctg gaggccgcgc tggaagaact ccccggtcgc
    16861 gatggccgcc aacgcccttc ggcccgcgtc gagttcggcg gcgagggccg cttcggcctc
    16921 cttgtgcagc cggttgccct cggcgcggtg ccgcagccag tcctccagca gttcccggct
    16981 cgccgggtcg agcaggcggg cggcgtcggg gacgccgggg acgcggtcgt tgtggatgtc
    17041 gcgccgcagc cgcagcagtt cgtggcgccg gtcggcgggc agctccggca cggccgcgtg
    17101 cagcgcgtcc tccaggcgcc cgcgcagctc ctcgcgtcgc tgccgggtct cctcggcctc
    17161 cgcgagcagc gcccaggtgc gtgccggggt cagcgcggcc agctcggacg ggccgagcgt
    17221 gccgcggcgg tagaggtagt aggggctgaa cccgtcgggc gcgccggcag cgtcgggcgc
    17281 gccgggcacc cgggtcgtgt cgttcaccgt ggcatcaccg caatctccca gttcgggtcg
    17341 gggcgtacgg cgccgacgca gatctgcgcc tgggtcccgc cgtccgtgtc cgcgccgccg
    17401 tcgaggccgt acgccgtgtc gatcagggtc acgtcgaacc cgaggacggc gtggccgctg
    17461 aggccctcgg cggccgcggc cagcgtcacc gcctcgatcg ccgcgcccac ggcgagctgc
    17521 tgcgcgcggt aggcgcgcgg gccgcccgcc ggccgccagt cggccggggt caccgggtgg
    17581 acggtgaagg cggccagctc ggcgttgaag gaggcggcga acagcgcctc ctgcacccgg
    17641 cgcgcgctgc cgggcccggt cccctccccc acgggcagca gcgcgcccag ctcgtgcgcg
    17701 taccggtacc agcccggcgg cacgccgcgc acccggtgca cggcgcagta caggcgggtc
    17761 cgcgcggccc acccggccgg cccgtccacc ccggctccgg ccagcgcccg cagcgcctcg
    17821 gccgcctgcc ccagcacccc cgcgagggcc tccccgtcgg cctcggcccc ggtgaacaag
    17881 cgcccccgtg agaaccgccg cgcggcggtc tcggcggcga ggagatcgag ggcgcggggg
    17941 gcgggcaacg gcaccgggcc gaccggcacg gcatcctcgg gcacggggcc gggcgcggcg
    18001 tccccgggca cggggccggg cgcggcggcc ggtacggcgt ccccgggcac ggggccgggc
    18061 gcggcggccg gtacggcgtc ctcgggcggc cgggcgggcg cggcggtgct cgtgtcctcg
    18121 cgggccgcgc gctggaaggc ggtgaagcgg tcggagcgcc gtaccgtccg ggagcgctcc
    18181 agcagggcgg ggcggggcgg ggcgtcgggt ccgccggtgt ccgccctgta cgggaggtac
    18241 ggtccgagcg tcaccgccgc ccacgcgttc tcctcctccc cgtcgaggcc gaggcaggcg
    18301 tgcacggcct cgtcgtcgaa gaccgtccgc acctccgcgt gctcccactc ggcccgcgcg
    18361 aggcgggcgg cgcggccgag ggcgaccccg gcgtcgacca ggccgaggcg ggtcgcgaaa
    18421 tcgccgtact tgtagaagtt cttccagaag cggctggtca ggacgagcac cgccgcgggc
    18481 gccgcctccg tcggcaggtg cagcgcggcg cgcagccggg ccgccgcgtc gccgccggcc
    18541 agcacggtca gctcgtgccg gtaggggtcg tagtggcaga cctgcccggt cgcggtgagg
    18601 gcggcgtaca cctcggtcgg gtacatcgcc ccgcccgacg ggacgggccg gcgcagctgc
    18661 acctcgggcc cgtggtgcgg acgcgggtcg gccggggtgg cggcgatgcc gccggacggg
    18721 tcggtgcgga tccggctgac ggcgaagccg ccgtgcagga gccggtgcag ggccgcgagc
    18781 ggcggcggtc cgtcgggccg cagcggcagc cgccgcgctc cgctgtagac cttcaccggc
    18841 cagggcccgt cggcccagtc cacccgccag ccgtccgggt tggcggagcg cgggtcgagc
    18901 cgcagcccgg tggtgtaggt gtacgcctcg tcggtcgtca tggtcatggt cgtgcgggtt
    18961 ctccttgccg gctggccatc ggacggcatg tcctacggga aggggtgcgg gacggcgccg
    19021 atctcccggc cgggggccag caggctgcgg tagggcaggg tggtgccctc cgtgagccgg
    19081 ggcaggccgc gggtacggcg gttgcggtgg ccgaaggtca tcgggatcag gcccggcacc
    19141 agcacccgga cgcagtgcag gccgttgcgg cgcagctcgg gcatggtctg gtcgacgacc
    19201 aggacgtcga ggccgcagtc gaggacgccg gagacggccg cgtacaggtc ggcccgcagg
    19261 tcggcgtcct gcgtgcggag cgtcgagcgg acccggccga gcgggacggg gtcgccggtg
    19321 cggggccggt cgaggaggaa ggagaagcgg tcgcgggcct cgggcagcgc gccgaccgtg
    19381 gagtggtcct ccatgcggcg gatgaggaac gggtcgtcga gcatgcgcag cgcgtcgggg
    19441 cggcggcgct cgtaggcgtc ccgggtggcg aggaccgtgc ccaccagctc gtgcagggcg
    19501 ccggtgacgg cctggacggg gtcggggtgc gcgccgcagc ccgcgaagag ccggggcccg
    19561 tcgccgctgt cgttctcggc ggtgagcagc agcgccggga cgccgtactc catcgtggcg
    19621 tcgaagcagc ggaagtcgaa gccggtgaag aggcgggact tggccagcag gtggtccagg
    19681 gcgggcgagg tgccgtcgag ggcgacctct gggacgtcga gttcgcggta ccaggtgagc
    19741 aggaaggcgt cccgctcggc gagttcgcgc aggccgtgca ggacggcctc ctcgacgctg
    19801 ttgccgaggg cgcagccgtt cgaggtgtcg tagaagaagg agatctcgtc gtcgtggcgc
    19861 ggtccccaga acgcggcgcg ctccgggacg aggacgcgtc cgtcgcggcg gaaggagtac
    19921 gcgcccaccc agtcgatctc ggtgccgggg tcgaagggcc ggtaccggaa gccttcggag
    19981 gcgtagctct cctccgggtg ggtgcccagg tccggcgggt acagggcctg gtcggccacg
    20041 tccgcgtagc gggcccgcac ggggggcagg gtgccgccgc ggtgcaggcc ggcgtagcgt
    20101 tccagcccct ccaggacggc gacggtgcgg ctggtggcgt agtcggcggc gcggccgatg
    20161 gcgggctcgc ggcggcccca gcgcggcggc agctccaccg agcaggcccc gaaggggctc
    20221 tgcaggtcct gccgcagctc cttgaacagg ccgaggccgg cgtagaggta gtcgccgcgg
    20281 acggcgtccg cgggcagccg tccggtgcgc agggtggccg gggtgagctt ggtgagcggg
    20341 acggcggcgg gggtcagcgc gggcacggtg tcctcgcgga ggctgccgca gttcgggcag
    20401 ccggagtccg gcagcagggt ctgctgctcg accgtgccgg cggcgccgtc gaggacgagg
    20461 acgcggccgt cggccgggcc ggccggcccc tggcaggacg cgagccgggc gcggacgtac
    20521 tcctccacca gccgcagcac gccgggtccc cagatgcgga cgtcggcgcc gtgcggccag
    20581 gactcggcga ggctgtcgcc ctccaggccg ggcccgaagg gcgagttggc ggtccgggtc
    20641 accaggcagc gcgggcagcc ctgggtgccg gggcgccaga cgggaccgat gtagacgagc
    20701 gagcgccagc tgccgacgaa gagcagggag cgtccggtgg ccaggcagtc gacgacggtg
    20761 tcctggaact cgccgagccc gtcgagcccg gcgacgagga cggtcgccct ggaggaccgg
    20821 ccgaagcgtg caccgccgtc cgggtcgggg gtgtcgtcgc ggccgaggcg ccggaccaga
    20881 tgctcggcga gcacgccccg cccgacgacg accggcggcc cggccggccc tgtgcggggc
    20941 tgcggggtgg tcgccgtact catgacgcct cctcggacac gggcagggcc acgacgcgga
    21001 cgcgggcgcc ggcctctccc ccgctgcggg tgccggtgtc ggtgtcggtg tcggtgtcgg
    21061 tgtcggtgtc ggtgtcggtg aggaagggca gcaggccggt gatctcgcgt tcgccttcgg
    21121 cggtgggcgc ggcggtccag gtcgcggtgg ccggggccag gaaggcggtg gcctcctggg
    21181 cgttcccggg cagcggcagg acgcgcgcca ccgcgttgag gagggcgtgt cccaccgccc
    21241 gttcccggtc ggtgcccacg cccgcggtga ccgcgccgtc gcgggtgcgc acgtgggcgc
    21301 ggacgacacc gtcgggcagc tcctcgacgg cggtggcggt ccagggcgtg ccctcggcgg
    21361 ccagcacccc ggcgaggtag cctgccgcgg tgtcgccggg cggcggctcc tccggcgccg
    21421 gagcccagtg gaggtccggc gtgggccggc cgagcgccgc gtgcagccgg gcgcgcagcc
    21481 gggcctcgcc cagggaccag ccggcgccga ccgcgccgta gcgcgcgtcc cctgcggtga
    21541 ggcggccggc cagcgactcc accgcgcaca gcacgacctg gttgcgggcc tcgcgcggcg
    21601 acagcgcccg gcacaccacg ccgagggcgg cgggcgcgtg ggcaccgccg tccgggtcgg
    21661 cgacctggca ggcactggcc gacagcggca gctgggccag gtcctcctcg ccgagcgcga
    21721 gcagcgggcc ggtgaccgcg tccgtcaggg cggcgcaggc cgccacgatc cggtcggaga
    21781 tccgcacccg ctcgggcggg tcctcggagc gcgggatgtc gggccgcacg gcgtcctcgg
    21841 gtgcggcggc cccggcgggc ggcagctgcc gcggtacggc gggctcgtgg tgcgggcagc
    21901 gcgggtgccg ccgggcggcg tggccgcgca ccgcggggac gaggggttcg acggtggtca
    21961 ccggcttgtc cccgggcggc cggaccccgg ccagccgggc gaaggtgtgc tgcgcgaccc
    22021 gcagcgcgcc gaccgcggcc ggggcgaccg ccggggcgag gcccgcggtg tcgccggtgg
    22081 cccggacggc gatcgagcgg tgcacgcact cccagcagta cggggtgccc agcccgggtt
    22141 cgagcgcggt gacgaagtcg ccgcaccggg cgaggacgcc gacggtcacc ccggcgcgcc
    22201 acagcgcgtg ctgggcgcgg gccagcgcgg cggcgtcggc gctgtcgtag gcgagcagga
    22261 cggcgtcggc gccctcgacg tcggggtgtc cggccagcgc ggccggtccg tccgccgcga
    22321 gcgggtcgcg cagccgccag cgcgccccgg gatccgccgc ggcggtctcc ttcagcacct
    22381 gctgtacggc ggtcaggtcg tcgtcgccgt ccgggaccac gtcgagccgg gcgatgccga
    22441 actcgcgcag cgcgtccagc agggcgtgca gcgcggtgcc gcggcccgcg cacaccacgc
    22501 gtgccgtgcg gacctgctgg aggcgggtga ccgggcggtc ggcgtggtgt tcgaggaacg
    22561 ccaggtgggt ggcgtaccgc tcgcgcatcc agccgggcac cggctcgacg gggtgggcga
    22621 cctccttgat gaagccgttg cgcagcatgg cccgcaccag ccccagcacg gaccggcggg
    22681 cccggtcggg caggtcgccg tagaggtcct ggagggtgcg ttcgccgtcc agcccggcga
    22741 agagggagct gaccagctgg taggcgccct ggccgcggac ggagaaggag ccggtgttgt
    22801 tgccgagcca gacgccgtcc tgctggcgga cgtagaaggc gtcggcgcgg agccggtagg
    22861 tgcgggtgag ggtgtcggtc agcgggtcgg cggccgggcc ggccggctgt gccctgtctg
    22921 ctgccacgtc tgtcatgtca gagcttcccg tgcgcgctgt agacggttgc ggcctcctgc
    22981 tcggaggcgc agctgatccg gctgggccgg tgctgttcgg ggagggcggc gcaatgcgcg
    23041 cggacggtgt ccgcgtcgac gctgccgacc accgtggcgg ccaggaactc caggccggtc
    23101 ggggcggtct cgacggtgac ccgtacgtcg ctgaccccgt cgagggcgag gacgtggcgc
    23161 tcgatctccc ggggccgtac gagcactccg gcgagcttct cggcgccgtc gaggcggcct
    23221 tcgaggcaga ggttgccgtc ggcgtcgaag cggccgtagt cggtgccggt cacgtggtcg
    23281 gcgggggcgg agggcgggct gccgggccgc caggtgcgcc ggcagcagcc ggggccggcg
    23341 acggcgaccg tgccgatgcc gcgttcgtcg gtgccggtca gccacacgga cttgccgggg
    23401 atcggccggc cgacgtgccg gttgtggccg gggtcgtggt cgagggcgat ggcgccggtc
    23461 tcggcggtgc cgtacaggtt gctgacggcg gcgccggtga agtggcggcg gatcagctcg
    23521 acccgcgggg cgctgaggtg gccgccgccg aggaacaggg cgacggagcc gaggtcggtg
    23581 gcggcgggcg cggacaggca ggccgccgcg gccagggccg ggacgccgag ggccagcacg
    23641 cgccggtcgc gggcgaggtc gtacagcggg ctccagtcgt gcggcgggtg cacgaccagg
    23701 tcccgtttca ggtagagggc gggcaggacg cacatgaaga acgcggcgga gaagcccagc
    23761 ggcagacagg tggccagcgc ctcgggcggg cccgcgggga acgcgtccgc gtacatcgcc
    23821 gcctcggcgt gcagggcgat ctgctcccac tcgtcggcgg ggccgacggc caccttgggc
    23881 gcgccggagc tgccggaggt gcacacgccc cacagcgggc gctcctgtgc cgcgagcggt
    23941 acggacccgt cgtccgggag ggcgtgcagc gccggggcga tctcccgccc ggtgacgccg
    24001 agggtgcgcg gcgacgccca gagcaggacc gtgtccggca cggtggccac ggcgaacagc
    24061 gcggccagcg cggggagtcc ggcggtgggg tcgatcgcgt acgcgccgcc gggacgcacc
    24121 tgcgcggcca ggtcgcggcc ggcggtgagc aggtcgtccc aggcggcgaa gtcgccgccc
    24181 cagcggacgc cggtcacggc acaggcccgg cccgccggga ggtgacgggg ggtcaggaag
    24241 cgctggaacg ctggtcggcc catgtcaccc acccctcgat cgtgcgcggc gcgtcgggca
    24301 gttcgggcag ggtccgcccg ggtgcctgcc gggcgaagta cgacaggacg acgaccgtct
    24361 ccagcgagtc gagccgccgc cgcgggtcgt cctcctggag cagcccggcc agctcctcct
    24421 gcaggtccgg tacgtcgtcc ggcgtccggg gtgtggtgcg ctgagatgtc acgtgtcgcc
    24481 cttctgcgtc gttcggggac cggcgggtgc gtcgtgcgcg gtgcgccaga agtcctcgac
    24541 cgcctcgttg aactcccgcg gccggtcgtg gccgaccaga tggccggcgc cggggacgac
    24601 ccggccgcgg acccggccgc cccagccggg cgcctgctcg gccgccgcgc gttcgacgga
    24661 cttcagggag ccattgagga cgagcgtcgg gacggtgagc gcggccacgt ccgccgcgcg
    24721 gaccagcgcg gtccgctcga agtcccgctc gacatgcccg gtgaccgcgt cgagcgtccg
    24781 cttccaccgg gtgccgtgca gctgctcgta ctcggcggcc agggccggct gctgcgcggc
    24841 gagcccctcg aaaccggcga tcagcgagag gaacgcgtcg cgggagacgt ccggcgcgaa
    24901 cccggtcagc accagcgagg cgaccaggtc gggccgggtg gccgcgcagc ggtgggcgag
    24961 cggcccgccc aggtaggagg cgccgatcag ccggccgggc ccgaagcgtt ccagcacggc
    25021 gacgaggtag cgcagcgcgt cgtcgaagta gtcctcggcg gcgtcacggc ggcagcggcc
    25081 gtgaccgggc agatccacgg gtacggtccg cagtcggccg tgccaggccc ggatctgcgc
    25141 ggcgaagtgc ccgtggccgg tgcccagcag cccgtgcacc aggtagacgg tgggcgtctc
    25201 cgggcccgtc gacgtcccgg tgtgcatcgg cgtctccgtg tccctcggcg tctcggtgtc
    25261 catcggcgtc tccgcgtcca ccggtgcctc agaccgcccg ggacgcctcg cccgcggggt
    25321 tcacgaagtg gtcgacgggt gtgccggacg cctcgatacg gccgaggatg tgccgcggcc
    25381 ggcgcaggtc ggcgacgagg aactgggagg acttctcgtc gttgcgggcc tcgcagccgg
    25441 cccggtaggg ggcgacgtcg gggctgccgg gcgagatcac gccggccagg cccagcgcga
    25501 cgtcctggaa ctcctgcggc tcccgcgtgg tgaggacgag ccgctgctcg ggacaggtga
    25561 aggcgaccac cgacatcagc cgcaggtagt cgtcgtcgcc gacccgcgtg gtgtcccggg
    25621 acttcatggc cggccgcatc cgcggcaccg acaggtcggc ggtcgcgccc cgggagcgca
    25681 gatggtcgcc gtgcgcgacc aggctcacca gctcggcgga gaggtcgtcg tgcagcccga
    25741 ccagcacccc ggggttcaca taccggtagc cggcgtccag ccagcggtcg aaggagacca
    25801 cccggcggtc gaagtcggcc ttgggtaccc cgacggaggt cttgcccatg aagcggcggt
    25861 acgtctcgcg gtcgtagctc tcctggaaca cgcacatggt gaccgggtcc tcccggccga
    25921 tccactcgcc gaggacgtcg atctcgtcct gctccatgct gccgatgttg aagtagaccc
    25981 gctcgaagcc caggtccagg gcggtgcgga tggcccagcc gatccggaag gcggaggcga
    26041 gccgggtgtg cttgtcctcg tactcgccgg tgaggaagcc gaccccgcgg acgccctcgt
    26101 ggtggtagag gatctccagc tgctcggtga tctccttgcg gccggagaac ttgcggtcga
    26161 ggcggtggtt gcccttccgc atggagcaca tcttgcactc ggagtcgcag tagttggtgg
    26221 tgtagagcgg cacgaaggtg tgcagccggg ggcggcgggc cccgcaccgg gcctccgcgg
    26281 ccgcctgcag ctcggcggtg ccgatcgagc ggtcctccca cagggcgagc gcgaccgccg
    26341 cccgcgactc ggccggctcc tcgccctcgg cgagggcgag gacggcacgg gtgtccaccg
    26401 tggccgcctc ggcgcgtacg tcctccagct ccggcaggac gaagtcaccg gtcattgcgt
    26461 gcgaggtcat tgcctgggag ttctgcgtca tgtgaattcc tctgcgaacg gccggaaggg
    26521 acccggccca tgtaacgcca cccgggaatt ccgaacaaga caccgaggaa acggaggact
    26581 ctttctccgt tactctcccc acctgcgcat tcacccagcc ctgaaccacc tacacggcgg
    26641 ttccgcagca gacccgaagc gcatggttag cagcgcttta gcggcctttt tgtgccgtca
    26701 cagcagtaca gcagcggggg atcagcagaa atgcaaaagg gccggaatcc ttgactcacg
    26761 gaagacccgc tgcatagcct ccgaggcacg cgctgcagga aatgcgcgaa gtaaattacc
    26821 gtcgacatgg aaggggtttc cggtggacgc tgcacacctg tccgacctgg acatcgacgc
    26881 tctcgagatc tccgagttcc tggacgagag ccgactggag gacagcgagg tcgtggccaa
    26941 ggtcatgtcg gcctcgtgca ccacctgcga gtgctgctgt tcctgctcct cctgatggag
    27001 acggcgccct gtaccggagc gatccggtac agggcgccgc ttttctcgac ccgaaaggaa
    27061 tccgcatgcg gcagaacctg ctgatgatct atgtgcacat ccctttctgc cattcgaagt
    27121 gcacgttctg cgactgggtc caggccatcc cgacgaagga tctcctgcgc aagcccggtg
    27181 actcggtgcg ccagaagtac atctccgcac tctgcgcgga aatcgcagag cggggcgcga
    27241 tgcatcgcgc ggcaggtgac atcccccatg tcctctactg gggcggcggc acggccagca
    27301 gcctcgacga gcaggagacc gcggcggtca tggaggcgct gcactcctcc ttcgacatga
    27361 gcacggtggc cgaggcgacc atcgagtgca gcccggacac cgtcgacgag cggaagctgt
    27421 ccttctaccg cggtctcgga ttcaaccggg tctccagcgg cgtgcagtcc ttcgacgacg
    27481 accggctgcg ccgcctgggc cgccggcaca ccgcggagca ggccgggcgc atcgtgcacg
    27541 ccgcgcgggc cgcggggttc gaggacgtct ccatcgacat catgtccggc ttccccgacc
    27601 aggaggccga cgagctggac cggaccgtcg accgtgctct tgagctgccg gtcaaccacc
    27661 tctcgctgta ctcgttccgg cccaccccgg gcacgttcat gcgccgccgg atggactcct
    27721 cggagcggcg gacgtacctg cgccgccagc aggcgctgtt cacgcgggcc cgccgggcga
    27781 tcgagggctt cggcctcagc gagtacgcca acggctactt cggcaaggtg tcgccgttcg
    27841 cctccatgta cttccagcac cgcgccgaca ccgtcggcct gggttcgggc gcgatctccc
    27901 tggtggacca gcggttcaag tcccaccaga agggcctgct gcactcctac gtcgacgatc
    27961 cgcacgcctt cgacatcgac gtgccggcgg gccaggaccg cgtcctggtg tcgctgctgc
    28021 aggccgggct cgccatgttc gacggcatcc cccgcgagga ctggcggcag cgcaccggca
    28081 cggacctcgc cgaggtgctg ctgcggccca cggtcgcgcc cctcgcggac ttcctgcgcg
    28141 gccgcggcct ggtcgaggac gaccacggca tccgcctccc gcgtgacatc gccggtctca
    28201 ccctgatcga gctggccttc gagatggcca tgtcccagcc ggagctggtg tgacctcggg
    28261 gccggggcag gccccggccg aggcggcaca cgcagccggg gcggcctggc tggagatcgg
    28321 gctcgacgcc cccgccgacg ccgtacccgc cctggtcgcc ggtgtcgtgc ggccgctgct
    28381 gcgggagccc gcggagccgg gggccgagcc cgcgcccggg ttcttcctgc ggggcgtcgg
    28441 cgcggcccag cccgccctgg tcgtccagct ggaggtgacc cccggcacgg acctcgccga
    28501 gccgtacgcc gcccgggccc gcgcgctcgc cgccgggctg ggcctccccg tgcaggtcgc
    28561 ggccggcccg gcgacgctcg tcccgctcgc cggctcggtc ttcgcggggg cggccctcgg
    28621 cccggtgacc cgcgccgcgc tggccgccgt atgccccgcg ctgctcgccg ccaccgaggc
    28681 cgccgaacag ggcaggcccg ccctgctggc cagtgccgtc gaactcatgt ccgcgcatct
    28741 gcgtgcggtc agcgtctccg cggcccccgg cccccgccag tgggaggagc tgcgcgaggg
    28801 cgtgccgctc ggcttcctca gctaccgctc gcacgcggag gcgttcctgg cctccagccg
    28861 cgacccgaag gccgcgcagg cgatgatgga cgcgaagtac acccgcgccg ccgccaccct
    28921 ggagcgcctg gtcgacggcg tcctcaccca gtgcgaggag cgcggcccgg tggtctccct
    28981 gcccgcgcgg cagtggtacg aggcgatgcg cgccgccaag cccgcggtga ccgagctgtt
    29041 ccgcgccgga accgacctcg ccctggacac cgaggagcag cccccggaca ccggcccgga
    29101 cggcaagggc ctgtccgaaa gcgcgttcca ccgcattgtc gagggctccg acgggctgcg
    29161 tgacttcctc gaccgcgacc cgtcctttct ggccacccga ctgctgacca gcctgctcta
    29221 cctttccctg agcagcgtcg gcatcgccct ggcggaacgg tatttcctct gctacgcggt
    29281 gagccgcgcc tgtgagtcga tcttcgacac cgacgccctc accgtcctgt ccggattggc
    29341 ccggacctcc ctggcgtcct gacgctccga caccctccct gacgtcggtt ttcggccgaa
    29401 tccatgcccg gaacccgtga tcgacgggcc gggcgggacc ggcctcttcc catgcaccgg
    29461 gcgctccccg cagaatcacg ttccgatata aggcccgacc ggataccgcc aagcggcgat
    29521 ccggcaccgg gacacatgaa gtagcatcgc gcccagataa ggacattcac cgccagaaac
    29581 gttcaaaaag atcaccgaga gatcactgac cgagcctgct ccaccacgag caatggggga
    29641 acatgaaagc tcaagagctg gaacgtgagg cgtgatcccg gcagggcgcc gcacggcgcg
    29701 gtcatcccgc gcccacgcgg cgccctgccg cgtatgccgg tttccccacg tcgcttccac
    29761 acaccgggag atgcgatgtc gtcagcacgg tcgatccact tgtgcaccac cgcaacgggg
    29821 gagttcgatg gagatcgatg tcctgggacc gcttgaggtc tcgcagaagt ccgcttcgat
    29881 tgtcccgacg gcttccaagc cgcgcaccgt cctggcgatg ctcgccgtct acaccaaccg
    29941 gctggtcccc ctgccctccc tcatgggaga actctgggga cccgaaccgc cggccaccgc
    30001 gaagacggcc gtacaggggt acatcctgca tctgcgcaaa cgtatcgccg agtccgccgc
    30061 gcgccgccca ccgggccagt tccccgaggc caaggacatc ctggtcaccc tccccggcgg
    30121 ctatctgctg cgcgccccgg gaaccgcggt ggtccttgag cagttcgagc agctggcctg
    30181 cgccggacac cgcgcccggg agaagggcga cttcgaggcc gcctcgcgga gcttcaccga
    30241 ggccctcggc ctgtggcgcg gccgcgccct cgccgacgtc gaggtgggcc cccagctggg
    30301 catagaggtg cagcggatcg aggaggcccg gctcaacgtc ctcgaccgca ggatcgaggc
    30361 cgacctccgg ctcggccgcc atcacgaact cctcggtgag ctgcggagcg tcaccgccca
    30421 ccaccccacc catgagggct tctgcgccca cctcatgctg gcgctctacc gctccggccg
    30481 ccgctgcgag gcactcgacg cctaccagcg catgcgcacc acactggtga acgaactggg
    30541 actggaaccc tccccgtccc tgcgccgcct ccagcgctcc ctgctggtct ccgaccgcga
    30601 actcgacgaa ctcaacgtca cctgggacgt cgccacgttc tgaccgcgcc cggcgaacgc
    30661 cgaagggcgg ccaccccgca cggggtgacc gcccttcgtc tcatgcgatc gctcgcttac
    30721 tggttgtacg gaccgtagtc gtagtcctcc agcgggacgg cctggccgga gcccgtgccg
    30781 aacggcgagt agtcgatgtc gtcgtagccg acggccgagt acatcgcggc cttggcctcc
    30841 tcggtcggct cgacccggat gttgcggtag cgggacagac ccgtaccggc cgggatgagc
    30901 ttaccgatga tgacgttctc cttgaggccg atcagggagt cggacttggc gttgatcgcc
    30961 gcgtccgtga ggaccctggt cgtctcctgg aaggacgccg ccgacagcca ggactcggtc
    31021 gccagcgagg ccttggtgat acccatgagc tgcggacgac cggaggccgg gtgaccgccc
    31081 tcctggacca cacgacggtt ctcgtgctcg aacttcgagc gctcgaccag ctcaccgggc
    31141 agcagctcgg cgtcgccgga ctcgatgatc gtcacacggc ggagcatctg ccggatgatg
    31201 atctcgatgt gcttgtcgtg gatcgacaca ccctgcgagt tgtacacctt ctggacctcg
    31261 ccgaccaggt ggacctggac ggcacgctgg cccaggatgc gcagcacgtc gtgcgggttg
    31321 gtggcaccca cggtgagctt ctggcccacc tcgacgtgct cgccctcgct gaccaggaga
    31381 cgggcgcgct tcgagatcgg gtacgccgtc tcgtcgctgc cgtcgtccgg cgtgatgacg
    31441 atcttcttgg tcttctcggt ctcctcgatc cgcacgcggc cggaggcctc ggagatcggg
    31501 gcgacaccct tcggggtacg ggcctcgaag agctcgacga cacgcggcag accctgggtg
    31561 atgtcgtcac cggccacacc accggtgtgg aaggtacgca tcgtcagctg ggtaccgggc
    31621 tcaccgatgg actgggcggc gatgatgccg accgcctcac cgatgtcgac cagcttgccg
    31681 gtggcgagcg aacggccgta gcacatcgcg caggtaccga cggcggactc gcaggtcagg
    31741 accgagcggg tcttgacctc ctcgacgccg cgctggacga gctcctcgat gaggacgtcg
    31801 cccaggtcgg tgccggccgg ggccagcacc tggccgtcga ccacgatgtc ctcggcgagg
    31861 cagcgcgcgt acacggacgt ctcgacgtcg tccgccttgc gcagcacgcc gtccgcgccc
    31921 cgctccgcga tcttgagctt gaggccgcgg tcggtgccgc agtcctcctc gcggatgatg
    31981 acgtcctggg agacgtcgac cagacgacgg gtgaggtaac ccgagtcggc ggtacgcaga
    32041 gcggtgtccg ccagaccctt acgggcaccg tgcgtggaga tgaagtactc cagcacggac
    32101 agaccctcac ggaacgaggc cttgatgggc cgcgggatcg tctcgttctt cgcgttcgac
    32161 accagaccac gcataccggc gatctgacgc atctgcatca tgttgcctcg tgcacccgag
    32221 ttcaccatca tgaagatcgg gttggtcttc gggaagttgt cgttcatcgc ctcggcgacc
    32281 tcgttggtcg ccttggtcca gatcgcgatg agctcctgcg tgcgctcgtc cttggtgatc
    32341 agaccgcgct cgtactgctt ctggaccttc tcgtcctgcg cctcgtagcc cttgacgatc
    32401 tccttcttcg cctcggggac gacgacgtcg gagatggcca cggtgacacc ggaacgggtc
    32461 gcccagtaga agccggacgc cttcaggttg tcgagcgtcg ccgccacgat gaccttcggg
    32521 tagcgctcgg cgaggtcgtt gacgatctcg gagagctgct tcttgccgac ctcgtagtcg
    32581 acgaacgggt agtcctcggg cagcagctcg ttgaagagcg cacggcccag cgtggtcttc
    32641 agcgtgaagc tgtcaccctg ctgccactcc ggctcgccct cctcgcgcac cggcgggacc
    32701 cagccgcgcg gcgggatggt gcccaccggg aagcggatgt gcaccggcgc ctgcagcgac
    32761 agctcgcccg cgtcgaacgc catgatcgcc tcggcgaccg acgcgaacgc acggtcctcg
    32821 cccttggcgc cccggccctc ggcgtccgtg gtgaggaaga acagaccgag gaccatgtcc
    32881 tgggtcggca tcgtcaccgg acggccgtcg gccggcttga ggatgttgtt cgaggacagc
    32941 atcaggatgc gggcctcggc ctgcgcctcc gcggacagcg gcaggtgcac ggccatctgg
    33001 tcaccgtcga agtccgcgtt gaacgcggtg cagacgagcg ggtggatctg gatggccttg
    33061 ccctcgacca gctgcggctc gaaggcctgg atgccgaggc ggtgcagggt gggcgcacgg
    33121 ttcagcagca ccgggtgctc ggcgatgacc tcttcgagga cgtcgtacac cacggtgcgg
    33181 ccgcgctcga ccatccgctt ggcgctcttg atgttctgcg cgtggttcag gtcgaccagg
    33241 cgcttcatca cgaacggctt gaacagctcc agcgccatcg ccttcggcag accgcactgg
    33301 tgcagcttca gctgcggacc gacgacgatc acggaacgcg ccgagtagtc gacacgcttg
    33361 ccgagcaggt tctgacggaa gcggccctgc ttgcccttca gcatgtcgct gagggacttc
    33421 agcgggcggt tgccgggacc ggtcaccggc cggccgcgac gaccgttgtc gaagagggcg
    33481 tcaacagcct cctgaagcat gcgcttctcg ttgttgacga tgatctccgg agcgcccagg
    33541 tcgagcaggc gcttcagacg gttgttgcgg ttgatgacac ggcggtacag gtcgttcagg
    33601 tcggaggtcg cgaagcggcc accgtccagc tgcaccatcg gacgcaggtc cggcgggatg
    33661 accgggacgc agtccaggac catgcccttg gggctgttgg aggtctgcag gaacgccgag
    33721 acgaccttca ggcgcttgag cgcacgggtc ttcttctggc ccttgccggt gcggatgatc
    33781 tcccggagct tctccgcctc ctcctccagg tcgaaggact ccaggcgctt ctgcagcgcc
    33841 gcggcaccca tcgaaccgtc gaagtacgtg ccgaagcggt cacgcagctc gcggtagagc
    33901 agctcgtcgc cctccaggtc ctggaccttg aggttcttga agcgggtcca cacctcgtcg
    33961 aggcggtcga tctcgcgctg cgcacggtcg cgcagctgct tcatctcacg ctcggcaccc
    34021 tcgcgcacct tgcggcgcac gtcggccttg gcaccctcgg cctccaactc ggccaggtcg
    34081 gcctcgagct tcttggcgcg ggcctccagg tcggcgtccc ggcggttctc gatctgctgg
    34141 cgctcgaccg agacgtgcgc ctccagggag ggcaggtcgc gggtacggcg ctcctcgtcg
    34201 acgtacgtga tcatgtacgc cgcgaagtag atgaccttct ccaggtcctt cggggcgagg
    34261 tcgagcaggt agccaaggcg cgacggaacg cccttgaagt accagatgtg cgtgacgggg
    34321 gcggccagct cgatgtggcc catccgctca cggcgcacct tggcgcgggt gacctcgacg
    34381 ccacagcgct cgcagatgat gcccttgaag cggacgcgct tgtacttgcc gcagtagcac
    34441 tcccagtccc gggtcggacc gaagatcttc tcgcagaaga gtccgtcctt ttcgggcttg
    34501 agcgtgcggt agttgatggt ctccggcttc ttgacctcgc cgtggctcca ctgacggatg
    34561 tcgtcagcgg tggccagacc gatccggagc tcgtcgaaga agttgacgtc gagcactatg
    34621 cgtcaatccc tctcagggtt gtaagtcttg gggtctgaaa cgggggtcct ggggccggcc
    34681 ggggactcag cggacttcac cgagtccccg taccggactc ccgtcagacc tcttcgacgc
    34741 tgctcggctc gcgccgggac aggtcgatac cgagctcctc cgcagcgcgg aagacgtcct
    34801 cgtcggtgtc gcgcatctcg atggacatgc cgtccgagga cagcacctcc acgttgaggc
    34861 acagggactg catttccttg atgagcacct tgaaggactc gggaatgccg ggctcaggga
    34921 tgttctcgcc cttgacgatg gcctcgtaga ccttcacgcg gccggtgacg tcgtcggact
    34981 tgatggtcag cagctcctgg agggcgtagg cggcgccgta agcctccagc gcccacacct
    35041 ccatctcacc gaagcgctgg ccaccgaact gggccttacc acccagcggc tgctgggtga
    35101 tcatcgagta cggaccggtc gagcgggcgt gcagcttgtc gtcgaccagg tggtgcagct
    35161 tcaggatgta catgtagccg accgagatcg ggtccgggaa cggctcaccg ctgcggccgt
    35221 cgaacagccg cgccttgccg gacgggagca ccatgcgctc gccgtcgcgg ttcgggatgg
    35281 tgtgctgcag cagacccgcg agctcgtcct cacgcgcacc gtcgaagacc ggggtggcga
    35341 cgttggtgcc gggctcgacc ttgtcggcgc cgatcgcctg gaggcgctgc gcccactcgt
    35401 ccgccaggcc ggagacgtcc cagccgcggc tggcgagcca gccgaggtgg atctccagga
    35461 cctgtcccgg gttcattcgg gacggcacac ccagcgggtt gaggatgatg tcgaccggcg
    35521 tgccgtcctc caggaacggc atgtcctcga tcggcaggat cttggagatg acacccttgt
    35581 tgccgtggcg gccggcgagc ttgtcaccgt cggtgatctt gcgcttctgc gcgacgtaga
    35641 cgcggaccag ctggttcacg cccggcggca gctcgtcgcc ctcctcgcgg tcgaagacgc
    35701 gcacaccgat gaccttgccg gtctcgccgt gcggcacctt cagcgaggtg tcacggacct
    35761 cacgggcctt ctcaccgaag atggcgcgca gcaggcgctc ctccggcgtc agctcggtct
    35821 cacccttggg cgtgaccttg ccgacgagga tgtcaccggc gatgacctcg gcaccgatgc
    35881 ggatgatgcc gcgctcgtcg aggtcggcga ggacctcctc ggagacgttc gggatgtccc
    35941 gggtgatctc ctcggggccg agcttggtgt cacgggcgtc gacctcgtgc tcctcgatgt
    36001 ggatcgagga gaggacgtcg tcctgcacga ggcgctgcga caggatgatc gcgtcctcgt
    36061 agttgtgacc ctcccacggc atgaacgcca cgagcaggtt cttgccgagc gccatctcgc
    36121 cgttctgggt ggccgggccg tcggcgagca cctggcccgt gatgacgcgg tcgccctcgt
    36181 tgacgatgac cttctggttg accgaggtgc cctggttgga ccgggagaac ttggccaggc
    36241 ggtacgtgat gtacgtgccg tcgtcgttgg cggtggtgat gtagtccgcg gagacctcct
    36301 ggaccacacc gtccttctcg gccttgacca cgtcgccggc gtcgacggcg gagcggtact
    36361 ccatgccggt gccgacgagc ggggcctcgg acttaatcag cggcacggcc tggcgcatca
    36421 tgttcgcgcc catgagggca cggttggcgt cgtcgtgctc gaggaacggg atcatggcgg
    36481 tcgcgaccga caccatctgg cgcggcgaga cgtccatgta gtccacgtcc tcgggggcga
    36541 cgtagtcgac ctcgccgcca cggcggcgga ccaggacgcg ggcctcctcg aaccgcatgt
    36601 cggcggtgag cggcgcgttg gcctgcgcga tgacgaagcg gtcctcctcg tcggcggtca
    36661 ggtagttcac ctcgtcggtg acctggccgt cgacgacctt gcggtacggg gtctcgacga
    36721 aaccgaacgc gttgacgcgg ccgtaggtgg cgagcgagcc gatcagaccg atgttcgggc
    36781 cttcgggggt ctcgatcggg cacatgcggc cgtagtgcga cgggtggacg tcacggacct
    36841 cgaagccggc ccgctcacgg gagagaccac ccgggccgag cgcggacaga cgacgcttgt
    36901 gcgtcagccc ggacagcggg ttgttctggt ccatgaactg ggacagctgg ctggtgccga
    36961 agaactcctt gatggaggcg acgaccggcc ggatgttgat cagggtctgc ggcgtgatcg
    37021 cctcgacgtc ctgggtcgtc atccgctcgc ggacgacacg ctccatacgg gccagacccg
    37081 tgcggacctg gttctggatg agctcgccga cgctgcgcag gcggcggttg ccgaagtggt
    37141 cgatgtcgtc ggtctcgacg acgaccggct ggccgttgtc gccgacggtc tcggtctcac
    37201 cggcgtgcag cttcaccagg tacttgatcg tcgcgatgat gtcctcgacg gtcaggatcc
    37261 cggcgtccag cggggtgtcc gtgcccagct tcttgttgac cttgtagcgg ccgaccttgg
    37321 ccaggtcgta gcgcttgggg ttgaagtaga ggttctccag cagcgtctgc gcggcctcac
    37381 gcgtgggggg ctcgcccggg cgcagcttgc ggtagatgtc gagcagcgcg tcgtcctggc
    37441 cctgggtgtg gtccttctcc agggtggcgc gcatggactc gtactcgccg aactcctcga
    37501 ggatctgctc ggtggtccag ccgagcgcct tgagcaggac ggtcacggac tgcttgcgct
    37561 tgcggtcgat gcggacaccg accatgtcgc gcttgtcgat ctccatctcc agccaggcac
    37621 cccgggacgg gatgatcttg gcggagaaga tgtccttgtc ggacgtcttg tcgatgctgg
    37681 agtcgaagta gacaccgggg gaacggacca gctgcgacac cacgacacgc tcggtgccgt
    37741 tgatgacgaa cgtgcccttg ttcgtcatga gcgggaagtc gcccatgaag acggtctggg
    37801 acttgatctc gccggtctcg ttgttggtga actcggccgt gacgaagagc ggcgcggcgt
    37861 aggtgaagtc gcgctccttg cactcgtcga tcgagttctt cggcggctcg aagcggtggt
    37921 cgcggaaggt cagcgacatc gaccccgaga agtcctcgat cggggagatc tcctcgaaga
    37981 tctcctcgag gccggacttg gtggggacgt cctgaccgtt ctcgagagcc tcctcgaccc
    38041 gactctgcca ggcggtgttg ccgagcagcc agtcaaagct ctcggtctgc agcgcgagca
    38101 ggttcggaac ctcgagaggc tccttgatct ttgcaaagga gatgcgcagc ggggcggtgc
    38161 tggcgccgtt gttcgtattc gcggtcgagg cagtgcgcga ggcggccaag agggggtcct
    38221 tccgagggct cggactcact acgcgcgtac cggcccctcc cccgtacaca gagacagaga
    38281 tcccaggtcg gagatcatct gtcggtcagt gctcgagtga gggcagaccc ctggtgacgg
    38341 gcaggggaca gctaacaggc agcgcaaagg gtcagtgtag ccacaaggca cactgatgtc
    38401 cagtcccgca ttttcggaga ctccactgtt ctcaacgcct gcggcatgcc tgccctcaac
    38461 gcacgttgat actgccctct tcgtcgtcga tccatgcctc ggattcggat ccttgtgacg
    38521 acgcgtcctg agaattgcgc gctgcgtgcg gttcgtcaag gccccccttg cccgaaccgg
    38581 ggcggccgag acacgacgaa gatcacctta cccctcacga acacaggtgc aaggcagccc
    38641 gggccgtccc ccggggaacg ccgaagggcg accacccgga tggatgatcg cccttcggtg
    38701 cgttcgcgtt acagcccctg agggccgttc atgcggtcgc gaaggtctta cttgacctcg
    38761 acggaggcgc cggcgccctt gagggcctcg gcggccttgt cggcctgctc cttgttgacc
    38821 ttctcgagga ccggcttcgg ggtgccgtcg acgaggtcct tggcctcctt caggcccagg
    38881 gaggtcagct cacgcacgac cttgatgacc tggatcttct tgtcgccggc gccggtgagg
    38941 atgacgtcga actcgtcctt ctcctcctcg gcctcggcgg cggcgccacc ggcggcacca
    39001 ccggcgacga cgaccggcgc ggcagcggcg gcggtgacgt cgaacttctc ctcgaacgcc
    39061 ttcacgaact cggagagctc gatgagggtc atctcctcga actgcgcgag cagctcgtcc
    39121 tgggtcagct tcgccatgat ggcggtcctt ccactcaatt cggcaggtgc cggatgtact
    39181 ggataaggcg ggcgtacgtc gggcccgcta ggaccctcgc cggtcggtcg gcgtgggtcg
    39241 gaaagcgagc cgaattactc ggcaccgccc tgctcggcct gcttggcgcg cagcgcgtcc
    39301 acggtgcgga cgagcttcga cggcagcgcc tggaagacgg aggcagcctg ggactgcttc
    39361 gc
//
