LOCUS       NZ_BNBR01000006        21068 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence06, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000006
VERSION     NZ_BNBR01000006.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 563512)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 447052
            Orig. end                         :: 468120
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="furan"
                     /region_number="1"
                     /rules="(mmyO or AvrD)"
                     /tool="antismash"
     cand_cluster    1..21068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(mmyO or AvrD)"
                     /kind="single"
                     /product="furan"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21068
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11068](+)"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11068
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
     gene            complement(259..741)
                     /locus_tag="IE308_RS28625"
                     /old_locus_tag="GCM10018783_58090"
     CDS             complement(259..741)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136563.1"
                     /locus_tag="IE308_RS28625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58090"
                     /product="CarD family transcriptional regulator"
                     /protein_id="WP_003953493.1"
                     /transl_table=11
                     /translation="MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLT
                     VRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKV
                     AEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS"
     misc_feature    795..809
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            1398..2057
                     /locus_tag="IE308_RS28630"
                     /old_locus_tag="GCM10018783_58100"
     CDS             1398..2057
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130320.1"
                     /locus_tag="IE308_RS28630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58100"
                     /product="DUF461 domain-containing protein"
                     /protein_id="WP_190220129.1"
                     /transl_table=11
                     /translation="MSSSLRRGALAASVIAVSIASLAACGAGNDSQTLQIKPDNAATSV
                     GDIKIQNAVVVTQPERESTGPAAISATVFNTGDTAQTLDAIKVAGVDQPAEIKAPKGGK
                     LTVPAGGSVVIGGKGNAVATVESGHEAVRDGNVQKVTFTFSKTGDVALDAFVVPAESYF
                     SEYGPSEVPSASAEAPSGKPSESASGKPSASASGTPTDQASASASASASASESAGH"
     gene            complement(2141..2821)
                     /locus_tag="IE308_RS28635"
                     /old_locus_tag="GCM10018783_58110"
     CDS             complement(2141..2821)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008410337.1"
                     /locus_tag="IE308_RS28635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58110"
                     /product="response regulator transcription factor"
                     /protein_id="WP_190220130.1"
                     /transl_table=11
                     /translation="MTRVLVVEDEESFSDALSYMLRKEGFEVAVAATGPDGLDEFERNG
                     ADLVLLDLMLPGLPGTEVCRQLRGRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFS
                     SRELVARIRAVLRRRGEPEEVTPTALEAGPVRMDVDRHVVTVGGSKVDLPLKEFDLLEM
                     LLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGY
                     KFEP"
     gene            complement(2818..4110)
                     /locus_tag="IE308_RS28640"
                     /old_locus_tag="GCM10018783_58120"
     CDS             complement(2818..4110)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072375.1"
                     /locus_tag="IE308_RS28640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58120"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_110628910.1"
                     /transl_table=11
                     /translation="MDVNAAVAAAAAIAGVLTGVIAMLAFRWSERELKRPTRTSLHTDP
                     VLPPGVDTVLSVLRSSAVVLDEADGVVKASSAAYALGLVRGGKLAVEPMLQMARDTRRD
                     GEIRQVELDLPRRGTGRGEALAVSARVAPLGSRLVLLLVEDLTEARRIEAVRRDFVANV
                     SHELKTPVGALSLLSEAVMDASDDPEAVQRFAGRMQIEATRLTNLVQELIDLSRVQNDD
                     PLEDAEPVGVDELVNEAIDRCRHQAGTKNITMTAGGTADLRVWGNRGQLAAALGNLVEN
                     AVNYSPARTRVGIAARRVTAPGGDMIEIAVTDQGIGISDKDKERIFERFYRVDPARSRA
                     TGGTGLGLAIVKHVVASHGGEVTVWSAEGQGSTFTLRLPEAGAARDRDRALQHPALDDE
                     AGTRRTTSASSTASPPDPTAYETLSAPEVLP"
     misc_feature    complement(4097..4108)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            4348..5037
                     /gene="phoU"
                     /locus_tag="IE308_RS28645"
                     /old_locus_tag="GCM10018783_58130"
     CDS             4348..5037
                     /GO_process="GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA]"
                     /GO_process="GO:0045936 - negative regulation of phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="phoU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005476809.1"
                     /locus_tag="IE308_RS28645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58130"
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="WP_110628911.1"
                     /transl_table=11
                     /translation="MRDAYHEELDSIGDGLVEMARLVGSAIGRATTAILDADLKLAESV
                     IEADQKVDELQHGLEARAIALLARQQPVATDLRIVVTSLRMSADLERSGDLAQHVAKLA
                     RLRFPERAVPQDLHATILEMGQLAQRLMAKAAEVIITKDVDLALQLEQDDDAMDLLHRT
                     LFQHLIDERWKHGIETAVDVTLLGRYYERYADHAVAVAKRVVYLVTGEHADELQQDTQT
                     VTGVEGA"
     gene            5480..5728
                     /locus_tag="IE308_RS28650"
                     /old_locus_tag="GCM10018783_58150"
     CDS             5480..5728
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455570.1"
                     /locus_tag="IE308_RS28650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58150"
                     /product="SCO4226 family nickel-binding protein"
                     /protein_id="WP_110628913.1"
                     /transl_table=11
                     /translation="MARYMDIHRGMKGITADQLKQAHEADLAIEKDEGVHFERAWADPE
                     TGTVYCLSEAPSAEAVQRIHERAGHKADEVHAVPLQV"
     misc_feature    5808..5823
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    5878..5896
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 31.03"
                     /tool="antismash"
     gene            5927..6508
                     /locus_tag="IE308_RS28655"
                     /old_locus_tag="GCM10018783_58160"
     CDS             5927..6508
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_58160"
                     /product="hypothetical protein"
                     /protein_id="WP_229909201.1"
                     /transl_table=11
                     /translation="MSVLPSETSVPPSAAATRRLGLYDTWWTVAAGALAACLGIAACAW
                     VSLHLHADAALHSAALFLHLAALVLGFGAVLVADYYALLFLTGRCSLRDALTTTGRLHA
                     PIWAGLVGLVASGALLHPDLGSVLTRVKLGLVLALTLNGLQAGVLNRRMRDETGTPLTG
                     RLLAWGAGTALVSQVCWWGAVLIGFRNSQR"
     gene            complement(6570..7499)
                     /locus_tag="IE308_RS28660"
                     /old_locus_tag="GCM10018783_58170"
     CDS             complement(6570..7499)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (17-307). E-value: 3.8e-52.
                     Score: 169.3. Matches aSDomain:
                     nrpspksdomains_IE308_RS28660_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237538.1"
                     /locus_tag="IE308_RS28660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58170"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_110628914.1"
                     /sec_met_domain="ADH_N (E-value: 1.8e-09, bitscore: 32.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.5e-16, bitscore:
                     54.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAISQQRYGGLDVLQEVDLPVPQPGPGQILVRVRAAGVNPTDWK
                     NRARRVWFEQPPRVLGWDLSGTVEQVGFGVTLFRPGDEVFGMLPYPHGVGSHAEYAVGP
                     ARAFAAKPDEIDHVQAGALPLAALTAYQALVDTADVRPGQHVLIHAAAGGVGHLAVQIA
                     KHLGARVTGTASAAKHDFVRSLGADEVVDYRTTDFRDVVRDVDVALVPMTDATRIRTVE
                     VLRPGGTLVALLPGATEEELAACADRGVRYAAMLVEHDHTGMTAVADLARKGALRAHVQ
                     EVIPLSEAARAHALGEEGHVTGKLVLVP"
     aSDomain        complement(6579..7448)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS28660_PKS_ER.1"
                     /evalue="3.80E-52"
                     /label="IE308_RS28660_PKS_ER.1"
                     /locus_tag="IE308_RS28660"
                     /protein_end="307"
                     /protein_start="17"
                     /score="169.3"
                     /tool="antismash"
                     /translation="VDLPVPQPGPGQILVRVRAAGVNPTDWKNRARRVWFEQPPRVLGW
                     DLSGTVEQVGFGVTLFRPGDEVFGMLPYPHGVGSHAEYAVGPARAFAAKPDEIDHVQAG
                     ALPLAALTAYQALVDTADVRPGQHVLIHAAAGGVGHLAVQIAKHLGARVTGTASAAKHD
                     FVRSLGADEVVDYRTTDFRDVVRDVDVALVPMTDATRIRTVEVLRPGGTLVALLPGATE
                     EELAACADRGVRYAAMLVEHDHTGMTAVADLARKGALRAHVQEVIPLSEAARAHALGEE
                     GHVTGKLVL"
     CDS_motif       complement(7011..7073)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS28660_0001"
                     /evalue="3.50E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE308_RS28660"
                     /protein_end="163"
                     /protein_start="142"
                     /score="22.7"
                     /tool="antismash"
                     /translation="GQHVLIHAAAGGVGHLAVQIA"
     gene            7630..8973
                     /locus_tag="IE308_RS28665"
                     /old_locus_tag="GCM10018783_58180"
     CDS             7630..8973
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (7-355). E-value: 1.3e-53.
                     Score: 173.9. Matches aSDomain:
                     nrpspksdomains_IE308_RS28665_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672598.1"
                     /locus_tag="IE308_RS28665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58180"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_190220131.1"
                     /sec_met_domain="AMP-binding (E-value: 8e-47, bitscore:
                     154.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQSLTEALRSHEDREAIIFHGQSTSYRTLLTGVEKWRARLNEYG
                     IRPGQVVALESAYSPQACAALVALIETGAIIVPLVTLPDAKRAEFHEIAEVEAVITLDG
                     SEAGWTITTTGRTAGHELFTALRRERHPGLVLFSSGTTGRSKASVLDFTKVLARYRGGR
                     PARTLSFLNLDHIGGVNTLLHTLVHGGAVVTVAERTPDSVFAAIEAHRVEVLPTTPTFL
                     TMAVVSGAVRRHDASSLRLVTYGTEPMPEQTLLAVHEALPEVRLKQTYGLSELGILPTR
                     SKDDSSLWVRLGGSGFDYKIVDGVLWVRSEMAMLGYLNAPAPFDEDGYFNTQDMVVVEG
                     EYLRILGRRSEIINVGGEKVYPAEVENVVLEAGNIADVTVSGRPSPVTGMVVQATVKLV
                     RPEDEDAVAARVQDHCAARLEPYKVPLIVQVSQADQHSDRFKKLRSAA"
     aSDomain        7651..8694
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS28665_AMP-binding.1"
                     /evalue="1.30E-53"
                     /label="IE308_RS28665_AMP-binding.1"
                     /locus_tag="IE308_RS28665"
                     /protein_end="355"
                     /protein_start="7"
                     /score="173.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ALRSHEDREAIIFHGQSTSYRTLLTGVEKWRARLNEYGIRPGQVV
                     ALESAYSPQACAALVALIETGAIIVPLVTLPDAKRAEFHEIAEVEAVITLDGSEAGWTI
                     TTTGRTAGHELFTALRRERHPGLVLFSSGTTGRSKASVLDFTKVLARYRGGRPARTLSF
                     LNLDHIGGVNTLLHTLVHGGAVVTVAERTPDSVFAAIEAHRVEVLPTTPTFLTMAVVSG
                     AVRRHDASSLRLVTYGTEPMPEQTLLAVHEALPEVRLKQTYGLSELGILPTRSKDDSSL
                     WVRLGGSGFDYKIVDGVLWVRSEMAMLGYLNAPAPFDEDGYFNTQDMVVVEGEYLRILG
                     RRSEIINV"
     CDS_motif       8032..8079
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS28665_0001"
                     /evalue="2.40E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="IE308_RS28665"
                     /protein_end="150"
                     /protein_start="134"
                     /score="11.0"
                     /tool="antismash"
                     /translation="VLFSSGTTGRSKASVL"
     gene            8970..9707
                     /locus_tag="IE308_RS28670"
                     /old_locus_tag="GCM10018783_58190"
     CDS             8970..9707
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-175). E-value: 1.8e-12. Score:
                     39.5. Matches aSDomain:
                     nrpspksdomains_IE308_RS28670_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018520428.1"
                     /locus_tag="IE308_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58190"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_110628916.1"
                     /sec_met_domain="adh_short (E-value: 2e-34, bitscore:
                     114.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTTAGVALVSGGSRGLGQTLVTRLLAEGWQVATFSRTAGDFVE
                     QTLKAEPDRFFWTEADLLRPETVRAAGKAAIDRFGRIDLLVNNAGVLEQGLFVTMPPRR
                     AEDLVTANLTSPVVLAQVAARSMVASGGGQIINISSVNAVRGYRGVAAYSAAKAGLDGL
                     THSLARELGPAGIRVNTVVPGFFDSDMTEGVGPEYRERIQRRTPLGRLGDRAEVADAVL
                     FLASPRAGFVTGQRLVIDGGITC"
     aSDomain        8988..9494
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS28670_PKS_KR.1"
                     /evalue="1.80E-12"
                     /label="IE308_RS28670_PKS_KR.1"
                     /locus_tag="IE308_RS28670"
                     /protein_end="175"
                     /protein_start="6"
                     /score="39.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GVALVSGGSRGLGQTLVTRLLAEGWQVATFSRTAGDFVEQTLKAE
                     PDRFFWTEADLLRPETVRAAGKAAIDRFGRIDLLVNNAGVLEQGLFVTMPPRRAEDLVT
                     ANLTSPVVLAQVAARSMVASGGGQIINISSVNAVRGYRGVAAYSAAKAGLDGLTHSLAR
                     ELGPAG"
     CDS_motif       8997..9053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS28670_0001"
                     /evalue="1.10E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE308_RS28670"
                     /protein_end="28"
                     /protein_start="9"
                     /score="8.5"
                     /tool="antismash"
                     /translation="LVSGGSRGLGQTLVTRLLA"
     CDS_motif       9324..9377
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS28670_0002"
                     /evalue="4.30E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE308_RS28670"
                     /protein_end="136"
                     /protein_start="118"
                     /score="0.2"
                     /tool="antismash"
                     /translation="LAQVAARSMVASGGGQII"
     CDS_motif       9381..9467
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS28670_0003"
                     /evalue="3.80E-06"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE308_RS28670"
                     /protein_end="166"
                     /protein_start="137"
                     /score="19.4"
                     /tool="antismash"
                     /translation="ISSVNAVRGYRGVAAYSAAKAGLDGLTHS"
     gene            9701..9997
                     /locus_tag="IE308_RS28675"
                     /old_locus_tag="GCM10018783_58200"
     CDS             9701..9997
                     /GO_function="GO:0000035 - acyl binding [Evidence IEA]"
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (30-86). E-value: 5.7e-11.
                     Score: 34.6. Matches aSDomain:
                     nrpspksdomains_IE308_RS28675_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102210.1"
                     /locus_tag="IE308_RS28675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58200"
                     /product="acyl carrier protein"
                     /protein_id="WP_190220132.1"
                     /sec_met_domain="PP-binding (E-value: 3.6e-11, bitscore:
                     38.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSNTLTDTRTTDVQATVVQEIVAILDEDTVDELGELTADTELSA
                     LGLNSLAFARLIIKLERALGVDPFSQGGDFVALRTVGALAGAYEQALSARTEA"
     aSDomain        9791..9958
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS28675_PP-binding.1"
                     /evalue="5.70E-11"
                     /label="IE308_RS28675_PP-binding.1"
                     /locus_tag="IE308_RS28675"
                     /protein_end="86"
                     /protein_start="30"
                     /score="34.6"
                     /tool="antismash"
                     /translation="VDELGELTADTELSALGLNSLAFARLIIKLERALGVDPFSQGGDF
                     VALRTVGALAG"
     gene            10001..11068
                     /locus_tag="IE308_RS28680"
                     /old_locus_tag="GCM10018783_58210"
     CDS             10001..11068
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) furan:
                     AvrD"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672595.1"
                     /locus_tag="IE308_RS28680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58210"
                     /product="AvrD family protein"
                     /protein_id="WP_190220133.1"
                     /sec_met_domain="AvrD (E-value: 7e-104, bitscore: 342.7,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATTTLLHLPSVDDYLGPSATRFFSAGYRRAEHTVDDLRISTG
                     TATGDRPGVSARVSLAYPRDWSKKKASTDLFPHVSTVDMLVIGIQLCEAYLAHVHRLGA
                     ADRRRARVRKITLKAGTTPQEELTGLTAGAELRRTHQDPAAAGGHVSTFTAHVGVMTAR
                     YEIEHAVADEPRGEGTYASLDDVLGPAAARYYGDGFKLRSHTVTDVRADVAELTATATV
                     AAHDLPGYADAVTAGLDGERLAGELTPVDCFVTNLQLIQVLMYELDGIRRQDSNTLWMQ
                     QTVLTATGPAHPADRPATAEAALTGSWLVPLRGGLWRDVAISARLGGYEMQCSFAHELP
                     PFAAAAAAADPTPRA"
     misc_feature    10118..10120
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11070..11777
                     /locus_tag="IE308_RS28685"
                     /old_locus_tag="GCM10018783_58220"
     CDS             11070..11777
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020135627.1"
                     /locus_tag="IE308_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58220"
                     /product="AAA family ATPase"
                     /protein_id="WP_110628919.1"
                     /transl_table=11
                     /translation="MKISVSGTYSAGKTSTVMALSHYLGLPRTLAKTIREILPEAVPGK
                     ALAEVTPAEFLHLMLRRHCGRAVAEARLGDSFLSDGSSLQEWLYGAARVRHGMNPNATA
                     ANDGGLAPEVTPEMRFFGEVVDEYGKAFRRHVQETYDVFIHLEHELEITSDGHRPMNKG
                     FRDTIDRMLLDTVRELGIPLHRISGTMPERMEKITAVLGLTPVMSIEEALALGKREYDA
                     QDFRLETERAAAA"
     gene            11774..13399
                     /locus_tag="IE308_RS28690"
                     /old_locus_tag="GCM10018783_58230"
     CDS             11774..13399
                     /EC_number="1.11.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040286.1"
                     /locus_tag="IE308_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58230"
                     /product="vanadium-dependent haloperoxidase"
                     /protein_id="WP_229909203.1"
                     /transl_table=11
                     /translation="MNALNRRRLLVSTAALTAGLGLPLEAHAAYGADAATSSAYSERSR
                     TGRKLRQRAAERDYPATLPDHPVNGEESLPSKIASYSKGLPHNDLGEVDVTAYARLIHA
                     LTTGNPADFEAIPSAGERKQLGPQGGLAYDLAGPDPFKLVVPPAPRMDSAQGAAEMAEL
                     YWLAMLRDVKFTDFEDSPLAAAAAADLSTYSDIHAPKQGGGITPQTLFRGNTPADLTGP
                     FVSQFLLRTVQYGTLRVPQLHDTVAPGVDHGTDFAEWLALQRGAARSTQRDFAGTRYLQ
                     TPRDLAHYTHFDVLYQAYLNAALILLALPQAAVQDRGNPYLTSKNQMGFPTYGTPHLVS
                     LLAEAAIRAIKHTEYQQFYVHRRARPEAFGGRIEVHLRRSPGRYTGLLHEEILRSEVLE
                     RTRAATGSYLLPLSFPEGSPMSPSYQSGHATVAGACTTVLKAWFDESYVLTDPVVPSAD
                     GKSLVPYTGAGQDSLTIGGELNKLAANIGAGRAASGVHYRTDNTAAYTLGETIALELLR
                     EQKPLFNEGGGFSVTCFDGTAVTI"
     gene            13444..14427
                     /locus_tag="IE308_RS28695"
                     /old_locus_tag="GCM10018783_58240"
     CDS             13444..14427
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521802.1"
                     /locus_tag="IE308_RS28695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58240"
                     /product="aldo/keto reductase"
                     /protein_id="WP_190220134.1"
                     /transl_table=11
                     /translation="MRKTQLGTQGLEVSAVGLGCMGMTFGYGSVEESRSIATIERALEL
                     GVDFLDSSDHYGPETNETLIGRAIAGRRDEVIVATKFGSYSTETPPRIPDGRPETVRWA
                     VEGSLKRLGTDYIDLYYQHRVDPRVPVEETVGVMAELVAEGKVRYLGLCEASAQTIRRA
                     HAVHPITAVQSEYSLWTRDAEEEVLPTLKELGIGFVAYSPLGRGFLTGTISSLDSLAEN
                     DFRRIAPRFQGDNLDANRGLLRRLQEIAGERGVTPAQVALAWVLRPAEGIVPIPGTTRP
                     QRVDENSAALDIALTDTEIAELSAVFAPGSAVGDRYPAPMMATLNG"
     gene            complement(14489..15457)
                     /locus_tag="IE308_RS28700"
                     /old_locus_tag="GCM10018783_58250"
     CDS             complement(14489..15457)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.5"
                     /locus_tag="IE308_RS28700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58250"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190220135.1"
                     /transl_table=11
                     /translation="MQIVYAITGKSAEAKAPPRGAGEVPEEGAAAAKPAAGAVGTGSGR
                     SSSSEARRRKELRDFLVNRRGRLTPGDVGIPHYGRRRTPGLRREEVAFLAGVSASWYQW
                     LEQGRNISVSPQVLDAITKVLRLDQAERTYLYVLAGLNPPLPLSSEPLEVDVMLARLTE
                     NNLPYPAFVVDPYWNLVTANQATYDLLGYRKTDRNSLVTFFTSPLVRSRVLNWAELAPW
                     IVAQYRYGMTTRPGDLGFEIVVGELTKKSPEFAELWARHDVRAEGVNVKVVDHPELGVL
                     HFDVTRMRIPQFPDLLIVLYNPRPEQETGVDTRGILNAAHL"
     gene            complement(15780..16877)
                     /locus_tag="IE308_RS28705"
                     /old_locus_tag="GCM10018783_58260"
     CDS             complement(15780..16877)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992960.1"
                     /locus_tag="IE308_RS28705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58260"
                     /product="DUF1152 domain-containing protein"
                     /protein_id="WP_190220136.1"
                     /transl_table=11
                     /translation="MTRLIVAAGGGGDAVAAAMLHAALYGGEEPAVILTYAWDRLVVDP
                     VPGPRSTSDFEGLAPLTSAVRTVPASARPVAPTRSTLPRLAAELPHTFALLDPQRGVEG
                     VTRQLEEVVRQLEPESIDLLDVGGDILAQGGEPTLKSPLADALTLAAACQVNASVRLLV
                     AGPGLDGELPPDALRPLLGPVVHTFTATDVEPVSSVLEWHPSEVAAMLAATARGVRGSC
                     EVRDAGPAVALTDEGPRVHAVDLDEAVNRNRLARAIMTTAALDEVEAYAREICGISEID
                     HEREKAARLSEQPPVEIDADVVSAQLDRFEAEARRRGVTHTTFRRLTEALNLPGSQREA
                     LRRLVIDSRPEQYEPPLWRVTATPE"
     gene            17437..18825
                     /locus_tag="IE308_RS28710"
                     /old_locus_tag="GCM10018783_58270"
     CDS             17437..18825
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020124096.1"
                     /locus_tag="IE308_RS28710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58270"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_190220137.1"
                     /sec_met_domain="Pkinase (E-value: 5.5e-49, bitscore:
                     161.8, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVYEGVDTRLRRSVAVKVFRPGPDPQTEDRLTAEAVLLARLQH
                     PGLVTVYDAGRHDDRTYLVMQLIEGPTLRGILASGALPERRVVEVGAALARVLAYVHQS
                     GVVHRDIKPSNILLDTAGAPHLADFGIARLANATRHTAPDVLIGTAAYLAPEQVKGRQI
                     GPAADVYALGLVLLECLKGELEYQGTPLEATVARLHRPPDVPAWLPPELAALLRAMTAQ
                     DPEARPDAEQCAQALASRHTGPAPYPLPLPAPSGSALPTPPATPPGTKEHIRSQDAVVT
                     RRGLPGGTRHGRRLAAGTALALSVALGATLAATSSTSESADRNAGTPATTPAHPPSGTA
                     TAKSGPGAPPPTRSHGTQPPSGTSGASDPAAATTGSHAQPASRTLGAPDPAAAPGSSRG
                     ASAPHTSHRPPGSASPSTPTATGATGPTQTTPAASPTTGTAPASPRPSKGKATGAPPKP
                     SPTR"
     gene            complement(19166..19765)
                     /locus_tag="IE308_RS28715"
                     /old_locus_tag="GCM10018783_58280"
     CDS             complement(19166..19765)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS28715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_58280"
                     /product="hypothetical protein"
                     /protein_id="WP_190220138.1"
                     /transl_table=11
                     /translation="MESARRSAYADFLSAVDVFVRIVTALPDMPRASRRELLDQKATAV
                     VQARAGVAVLGPPPVLSQAERVAEQCAQLEKLALRRAVLRSAISALEDAWCPRNAEWCQ
                     DPHHNSAHVAWGLLCEWGRLEDEERWEKLDLLEFTLQESHALDAEQVKHVMEVANCVAF
                     WDEMIGGFVRDPLLERFQAVRDSFADVAYGSLDLVA"
     misc_feature    complement(19412..19414)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20272..20898)
                     /locus_tag="IE308_RS28720"
                     /old_locus_tag="GCM10018783_58290"
     CDS             complement(20272..20898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004986492.1"
                     /locus_tag="IE308_RS28720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_58290"
                     /product="hypothetical protein"
                     /protein_id="WP_190220139.1"
                     /transl_table=11
                     /translation="MSVRGREPVGPSDWAVERFGRHAGALAAAVPLQLARAHAKAHAAH
                     IAAGLKKRSPYGVALAGAVREGLADAARELGESVRDVRGYEYAVINEHALFPFRYADKP
                     RPLDRARLPANASPTRQRLFRAHGPQAPDGLFEVDAGLATEEYLGLHEAFEELGASTRL
                     VCVFFTADAENGIHVIHWGEAHLEPDRTFRWLHKEQLPVAPLPLE"
     misc_feature    21026..21041
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.88"
                     /tool="antismash"
ORIGIN
        1 gccggacggg acacgttcga ccggaccctt ccgtgaccat ggtcgaaccg gttgcccggc
       61 cccggcacac aggatcgggg gaaatctccc cgttgtacgg cacggacgcg tcgtctctgc
      121 gcaggaagtc gtgactgcgt acgaacatgc cgcagcgccc ggcgacggat tgtcacgtca
      181 tcgggcaccg cggcatcgcc atgtcagcgc atgtaggtca tgtacgtcat ggcaggtact
      241 gagcggcctg cgccggcgtc aggacgcgag gacctcgtcg agcagggcct cggccttgtc
      301 ctcgttcgtg ttctccgcga gggccagctc gctcaccagg atctgccggg ccttggcgag
      361 catgcgcttc tcacctgcgg agagtccgcg ctcgcgctcg cgacgccaca ggtcgcgcac
      421 gacttccgcg accttgatga catcgccgga ggcgagcttc tccagatttg ccttgtagcg
      481 acgcgaccag ttcgtgggct cctcggcgta cggcgcgcgc agcacctcga agacccggtc
      541 cagcccgtcc tgaccgacca catcacgcac gccgacgaac tccgcattgt ccgctggcac
      601 acgtaccgtc aggtcaccct gggcgacctt cagcaccaag taggtcttgt ccacgccttt
      661 gatctggcga gtttcgatgg cctcgatcag cgcggccccg tgatggggat agaccacggt
      721 gtcgccaacc ttgaacgtca tgtgacaggt accccttccg tggctatcca gggtaacacg
      781 gatacggcgt cttctgaatg gcgttttcgc aggtcagggc atatctcggg gcttgacaac
      841 agcaacagga acgtgctgcg cgggccgagc ggaagcgggt attcgcaggt cggagcggct
      901 gtgcggggga ggtgaaacgc gtacgttaca cgcatccgga ggctccctca ggcggccgaa
      961 cgtccccaaa tgtccggttc cggatgtgcg acttccgcta ctccgttcgg tgtcccggag
     1021 gtggatacgc gccgaatccg gaattgatca cgggcaccgc acaaggccgg acgctacccg
     1081 cgttgatcaa ttcccggaca gcggcaccgg agggccgcgc attccttcac ggaaaatccg
     1141 cgcgacagcg caggtgagac cggcggcgac ttatgtgaat ggcggaccgg tggccggtca
     1201 aagtgactga tgggtcagtt gtggcggagg tgatcgcgcc gcctcgcgcg cctgcacgag
     1261 ggaagccgga acgcccgggg gagggtcggg tgcggcggcc gggggacggc tcggtaacct
     1321 aaggccgctg acagaccctt agggcggctt tgtgacacgc gccgctctgt ccctgcgttc
     1381 aaggagttgc cgccgccgtg agcagcagcc ttcgacgcgg cgccctcgcc gcctccgtca
     1441 tcgccgtctc catcgcctcg ctggccgcct gcggcgccgg gaacgactcg cagacgctcc
     1501 agatcaagcc ggacaacgcg gccaccagcg tcggcgacat caagatccag aacgccgtgg
     1561 tcgtcaccca gcccgagcgt gagtcgacgg gtccggcggc gatctccgcc accgtcttca
     1621 acaccggtga caccgcccag acgctggacg cgatcaaggt ggccggtgtc gaccagcccg
     1681 ccgagatcaa ggctcccaag ggcggcaagc tgaccgtccc ggccggcggc tccgtcgtca
     1741 tcggcggcaa gggcaacgcc gtggccaccg tggagagcgg ccacgaggcg gtgcgggacg
     1801 gcaacgtgca gaaggtcacc ttcaccttca gcaagaccgg tgacgtggcg ctggacgcgt
     1861 tcgtcgtccc ggccgagagc tacttctccg agtacggccc gagcgaggtg ccaagcgcgt
     1921 ccgccgaggc gccctccggc aagccgtccg agtccgcctc gggcaagccg tcggcctccg
     1981 cctccggcac cccgaccgac caggcctccg ccagcgcttc ggcgtccgcg tcggcctcgg
     2041 agtcggccgg tcactgagac accttggata cgccggaagg gcgggacctc tccgtgaggt
     2101 cccgcccttc cggcgtaccg gcgtgtccgc cccgcggtgt ctacggctcg aacttgtagc
     2161 cgaggccgcg cacggtcacc aggtagcgcg gggcgcccgg gtccggctcg atcttggcgc
     2221 gcagccgctt gacgtggacg tcgagggtct tggtgtcccc gacgtagtcg gcgccccaga
     2281 cgcggtcgat gagctgcatg cgggtgagca cccggccggc gttgcgcagc agcatctcca
     2341 gcaggtcgaa ctccttcagc ggcaggtcga ccttggagcc gccgacggtg accacgtgcc
     2401 ggtcgacgtc catgcggacc gggccggcct ccagcgcggt cggggtcacc tcctccggct
     2461 cgccgcggcg gcgcaggacg gcgcggatgc gggcgaccag ctcacgggag gagaagggct
     2521 tggtgacgta gtcgtcggcc cctatctcca ggccgacgac cttgtcgatc tcgctgtcct
     2581 tggcggtcac catgatcacg gggacgttgg agcggccgcg cagctgacgg cacacctccg
     2641 tgccgggcag ccccggcagc atcaggtcga ggaggacgag gtcggcgccg ttgcgctcga
     2701 actcgtcgag tccgtcgggt ccggtggccg cgacggccac ctcgaagccc tccttgcgga
     2761 gcatgtacga cagggcgtcg gagaaggact cctcgtcctc gacgacgagc acacgggtca
     2821 cggaaggacc tccggggcgg aaagcgtttc gtacgcggtc ggatcagggg gtgacgcagt
     2881 ggatgaggca gaggtggtgc ggcgggtgcc cgcctcgtcg tcgagggcgg ggtgctgcag
     2941 ggcgcggtcc cggtcgcggg ccgctcccgc ctccggcagg cgcagcgtga aggtggagcc
     3001 ctgtccctcg gcgctccaca ccgtgacctc cccgccgtgc gaggcgacca cgtgcttgac
     3061 gatggccagg ccgaggccgg tgccgccggt ggcccgggac cgggccgggt cgacccggta
     3121 gaagcgctcg aagatgcgct ccttgtcctt gtcggagatg ccgatgccct ggtcggtcac
     3181 ggcgatctcg atcatgtccc cgccgggcgc ggtcacccgg cgggcggcga tgccgacgcg
     3241 ggtgcgggcc ggggagtagt tgacggcgtt ctcgacgagg ttgccgagcg cggcggcgag
     3301 ctggccgcgg ttgccccaca cccgcaggtc ggccgtaccg cccgcggtca tggtgatgtt
     3361 cttggtgccg gcctggtggc ggcagcggtc gatggcctcg ttgaccagtt cgtcgacgcc
     3421 gacgggttcg gcgtcctcca gcgggtcgtc gttctgcacg cgggagaggt cgatcagctc
     3481 ctgcacgagg ttggtcagcc gggtcgcctc gatctgcatg cggccggcga agcgctgcac
     3541 ggcctccggg tcgtcggagg cgtccatgac ggcctcggac agcagggaga gcgcgccgac
     3601 gggcgtcttc agctcgtggc tcacgttggc gacgaagtcg cgtcgtacgg cctcgatccg
     3661 gcgggcctcg gtgaggtcct ccacgaggag cagcacgagc cgtgagccga gcggggcgac
     3721 gcgcgcggag acggcgagcg cctccccgcg gccggtgccg cgccggggca ggtccagctc
     3781 gacctggcgt atctcaccgt cgcgtcgcgt gtcccgggcc atctggagca tgggctcgac
     3841 ggccagtttg ccgccgcgga ccagaccgag ggcgtacgcc gccgagctgg ccttgacgac
     3901 gccgtccgcc tcgtcgagga cgacggcgga ggagcggagc acggacagga cggtgtcgac
     3961 gccgggcggg agcaccgggt ctgtgtgcaa agaggtgcgg gtcgggcgct tcagctcccg
     4021 ctcgctccag cggaacgcca gcatggcgat gacaccggtg agcaccccgg cgatcgctgc
     4081 cgctgcggcg accgccgcgt tcacgtccat ggctccaggt taggcacggg atgcgggctg
     4141 cccacagccg tccgggtgcg acctcgaaca ctcgtcgccc agagttcacc tgggagccag
     4201 taccggttca tttggggtga cggaatccga cgcgtacggc gtcgaacgtg ggagcgtggg
     4261 gttctgagcc ccgtcgacaa acctgagaag acgtacggga aaccgccgta ccggaacccc
     4321 cggcgcacac gtgagagagg gaccctgatg cgggacgcgt accacgagga actggattcg
     4381 atcggcgacg gtctggtgga gatggcccgg ctggtcggct cggcgatcgg gcgcgccacg
     4441 acggcgatcc tcgacgccga cctgaagctg gccgagagcg tgatcgaggc cgaccagaag
     4501 gtcgacgagc tgcagcacgg cctggaggcg cgggcgatag cgctgctggc ccggcagcag
     4561 ccggtggcga cggatctgcg gatcgtcgtg acgtcgctgc ggatgagcgc cgacctggag
     4621 cgctcgggcg acctcgccca gcatgtggcg aagctggcgc ggctgcggtt cccggagcgg
     4681 gcggtgccgc aggacctgca cgcgacgatc ctggagatgg ggcagctcgc gcagcgcctg
     4741 atggcgaagg ccgcggaggt gatcatcacc aaggacgtcg acctggcgct gcagctggag
     4801 caggacgacg acgcgatgga cctgctgcac cgcacgctct tccagcacct gatcgacgag
     4861 cggtggaagc acggcatcga gacggcggtg gacgtgacgc tgctgggccg ctactacgag
     4921 cggtacgccg accacgcggt cgcggtggcc aagcgggtgg tgtacctggt gacgggtgag
     4981 cacgcggacg agctgcagca ggacacgcag acggtgacgg gggtggaggg cgcctgagcc
     5041 ccgctccggg tggtgttcgg gggcgcgtgc ctggggcggt gcgctgatgt gcgccgttga
     5101 tgcgcccagc cgggcgggca tgcaatgggc acaggcacca gccgaggagg gaccatggcc
     5161 gaatccccca gcacccccag caccccgccc gaccccacgc aggaacgccc gaccgagcag
     5221 cccgccgaga tcaggaacct gatgctgatc ggcgcgtgcg ggtgcggttc ggggtgcggg
     5281 tgcggttgcc agtcgggcaa tccgtgccag tgcggctgag ggtggtggcg tagccgccgg
     5341 tacgacgacg agggcccggg tgcgttctgc gcgccggggc ccttcgtcgt cgtggccgcg
     5401 cggtcgccgt ggagaccggt ggggcgcagg atgaggggag gaaaggacag ggcgggacgg
     5461 cacggaagga ggtgcgggga tggctcggta catggacatc caccgtggca tgaagggcat
     5521 cacggccgac cagctgaagc aggcccacga ggcggacctc gccatcgaga aggacgaggg
     5581 cgtccacttc gagcgggcct gggccgaccc ggagaccggc acggtctact gcctctccga
     5641 ggccccctcg gccgaggcgg tccagcgcat ccacgaacgc gcgggccaca aggcggacga
     5701 ggtgcacgcg gtaccgctgc aggtctgacc acacgagacc caccggaacg gggacggcac
     5761 gccggcgccg tccccgtcgc gcgcgcccgc gctgcggtcg cgtgggcgac acatactggt
     5821 cacgcttggg tcgcggccgg gcgatcagcg gctttcggcc ttgaccggga aatgctctta
     5881 ggtgaggctt acctaaatct tgctatgtac gtcctaggag ccccctgtgt ccgtcctgcc
     5941 ctcggagaca tccgtgcccc cgtcggccgc ggccacccgc cgcctggggc tgtacgacac
     6001 ctggtggacg gtcgcggccg gcgcactggc cgcctgcctc ggcatcgccg cctgcgcctg
     6061 ggtctccctg cacctgcacg ccgacgccgc cctgcacagc gcggccctgt tcctccatct
     6121 cgccgcgctg gtgctcggct tcggcgcggt gctcgtcgcc gactactacg cgctgctgtt
     6181 cctgaccggc cggtgcagcc tgcgcgacgc cctcaccacg accggacgcc tgcacgcccc
     6241 gatctgggcc ggcctcgtcg gcctggtggc cagcggcgcg ctgctccacc cggacctcgg
     6301 ctccgtcctc acccgcgtga agctgggact ggtcctcgcc ctcaccctca acggcctgca
     6361 ggccggcgtc ctgaaccggc ggatgcggga cgagacgggc accccgctca ccggccgcct
     6421 cctcgcctgg ggagccggga ccgccctggt gtcccaggtc tgctggtggg gagccgtgct
     6481 catcgggttc cgcaacagtc agcgctaggc ctgtcgcgga agtcccgtcg tccgccggag
     6541 gacgggctcg gcggtgtccg ggtcaacggt cagggcacca ggaccaactt gcccgtcaca
     6601 tggccctctt cgcccagggc gtgggcccgc gccgcctccg acagggggat gacctcctgc
     6661 acgtgggccc gcagggcgcc cttgcgggcc aggtcggcga cggccgtcat gccggtgtgg
     6721 tcgtgctcca ccagcatggc ggcgtaccgg acgccccggt cggcgcaggc ggccagctcc
     6781 tcctccgtcg cgcccggcag cagggcgacc agcgtgccgc ccggccgcag tacctccacc
     6841 gtgcggatcc gggtggcgtc cgtcatcggc accagcgcca cgtccacgtc ccgcaccacg
     6901 tcacggaagt cggtggtgcg gtagtcgacg acctcgtcgg cgcccagcga gcggacgaag
     6961 tcgtgcttgg ccgcgctcgc cgtaccggtg acccgggcgc ccagatgctt ggcgatctgc
     7021 accgccaggt gaccgacccc gcccgccgcc gcgtggatca gcacatgctg cccgggccgc
     7081 acgtcggcgg tgtcgaccag cgcctgatac gccgtcagcg cggccaacgg cagcgctccg
     7141 gcctggacat ggtcgatctc gtccggcttg gccgcgaagg cgcgggccgg tccgacggcg
     7201 tactcggcgt gcgagccgac cccgtgcggg tagggcagca tgccgaacac ctcgtcgccc
     7261 ggccggaaca gggtgacgcc gaagccgacc tgctccaccg tgcccgacag gtcccagccg
     7321 aggacccgcg gcggctgctc gaaccacacc cggcgggccc ggttcttcca gtcggtcggg
     7381 ttgacgcccg cggcccgtac ccgcacgagg atctgaccgg gtccgggctg cggcaccggc
     7441 aggtccacct cctgcaggac gtccaggcct ccgtaccgct gctggctgat cgcgcgcatg
     7501 gtgctcctca gggaagaaga cggggtggtt ccgtcaccgt agggcgcggg cgggcggcgt
     7561 aggtggtggc cgtgacacca ggatccgcac ccacttcctg gccctcttcg cggccagcac
     7621 gatcgagaca tgatccagtc actgacagag gcgctgcggt cgcacgagga ccgagaggcg
     7681 atcatcttcc atgggcagag cacgagttat cggacgctgc tgaccggcgt cgagaagtgg
     7741 cgggcccggc tgaacgagta cggcatccgc ccggggcagg tcgtcgcgct ggagtcggcg
     7801 tactcgccgc aggcctgcgc cgcgctcgtc gccctcatcg agaccggcgc gatcatcgtc
     7861 ccgctggtca cgctgccgga cgccaagcgg gccgagttcc atgagatcgc cgaggttgag
     7921 gcggtcatca cgctcgacgg cagcgaggcc ggctggacca tcaccaccac cggccgcacc
     7981 gccggccacg agctgttcac cgcgctgcgc cgcgagcggc accccggcct ggtgctgttc
     8041 agctccggca ccaccggccg cagcaaggcc tccgtgctgg acttcaccaa ggtcctcgcc
     8101 cgctaccggg gcggccggcc cgcgcggacg ctgtccttcc tcaacctcga ccacatcggc
     8161 ggcgtcaaca ccctgctgca cacgctggtc cacggcggcg cggtcgtcac cgtcgccgaa
     8221 cgcaccccgg acagcgtctt cgccgcgatc gaggcacacc gggtggaggt gctgccgacc
     8281 acgccgacct tcctcaccat ggccgtggtc tccggcgccg tccgccgcca cgacgcgtcc
     8341 tcgctgcgcc tggtgacgta cggcaccgag ccgatgcccg agcagacgct gctcgccgtg
     8401 cacgaggcgc tgcccgaggt gcggctgaag cagacgtacg gcctgtcgga gctgggcatc
     8461 ctgccgaccc ggtccaagga cgactcctcg ctgtgggtca ggctcggcgg cagcggcttc
     8521 gactacaaga tcgtcgacgg ggtgctgtgg gtccgctccg agatggccat gctcggctac
     8581 ctcaacgcgc ccgccccctt cgacgaggac ggctacttca acacccagga catggtggtg
     8641 gtggagggcg agtacctgcg gatcctcggc cgccgctccg agatcatcaa cgtgggcggc
     8701 gagaaggtct acccggccga ggtcgagaac gtcgtcctgg aggccggcaa catcgccgac
     8761 gtcaccgtct ccggccggcc cagcccggtc accggcatgg tcgtgcaggc cacggtgaag
     8821 ctggtgcgcc cggaggacga ggacgccgtc gcggcccgcg tgcaggacca ctgcgcggcc
     8881 cgcctggagc cgtacaaggt gcccctgatc gtgcaggtct cgcaggccga ccagcactcc
     8941 gaccgcttca agaagctcag gagcgcggcg tgagcgacac gacggccggt gtcgccctcg
     9001 tcagcggcgg cagccggggc ctcgggcaga ccctggtgac gcggctgctg gcggagggct
     9061 ggcaggtcgc caccttcagc cgcaccgccg gcgacttcgt cgagcagacc ctgaaggccg
     9121 agcccgaccg gttcttctgg accgaggccg acctgctgcg gcccgagacc gtgcgggcgg
     9181 cgggcaaggc cgcgatcgac cggttcggcc ggatcgacct gctcgtcaac aacgcgggcg
     9241 tgctggagca gggcctgttc gtgacgatgc cgccgcggcg ggcggaggac ctcgtcaccg
     9301 ccaacctgac ctcgccggtg gtgctggcgc aggtggccgc ccggtccatg gtggcctccg
     9361 gcggcggcca gatcatcaac atctcctcgg tcaacgccgt gcgcggctac cggggtgtgg
     9421 ccgcctacag cgcggccaag gcgggcctgg acgggctgac ccacagcctc gcccgcgaac
     9481 tgggcccggc cggcatccgc gtcaacacgg tcgtgcccgg cttcttcgac tcggacatga
     9541 ccgagggcgt cggcccggag taccgcgagc gcatccagcg ccgcaccccc ctcggccggc
     9601 tgggcgaccg ggccgaggtc gccgacgccg tgctgttcct ggcttctccg cgggccggtt
     9661 tcgtcaccgg tcagcggctc gtcatcgacg gaggaatcac atgctgagca acacgctgac
     9721 cgacacgcgg accaccgacg tgcaggccac ggtcgtccag gagatcgtcg cgatcctcga
     9781 cgaggacacc gtcgacgagc tgggcgagct gaccgccgac accgagctga gcgcgctcgg
     9841 cctcaactcc ctcgccttcg cccggctcat catcaagctg gagcgcgccc tcggcgtcga
     9901 cccgttcagc cagggcggcg acttcgtcgc gctgcgcacc gtgggcgccc tggccggggc
     9961 gtacgagcag gcgctgagcg cccgtacgga ggcctgagcc atgtccacgg cgacgacgac
    10021 cctgctgcac ctgccctcgg tcgacgacta cctcggcccg tccgccaccc gcttcttctc
    10081 cgccggctac cggcgcgccg aacacaccgt cgacgactta cggatatcca ccggcaccgc
    10141 caccggcgac cgtccgggcg tgagcgcccg cgtctcgctc gcctacccgc gcgactggtc
    10201 gaagaagaag gcctccaccg acctgttccc gcacgtcagc accgtcgaca tgctggtgat
    10261 cggcatccag ctgtgcgagg cgtacctcgc ccacgtgcac cggctgggcg ccgccgaccg
    10321 tcgccgggcc cgcgtccgca agatcacgct gaaggcgggg accaccccgc aggaggagct
    10381 gaccggcctc accgcgggcg ccgaactgcg ccgcacccac caggacccgg cggccgccgg
    10441 cgggcacgtg tcgacgttca ccgcgcacgt cggggtgatg acggcccggt acgagatcga
    10501 gcacgccgtc gcggacgagc cgcgcgggga ggggacgtac gcctccctcg acgacgtcct
    10561 cggcccggcc gccgcccgct actacggcga cggcttcaag ctccgcagcc acacggtcac
    10621 cgacgtacgc gccgacgtgg ccgaactgac cgccaccgcg accgtcgccg cgcacgacct
    10681 gccgggatac gccgacgccg tcaccgccgg tctcgacggc gagcgcctgg ccggcgaact
    10741 gaccccggtc gactgcttcg tgacgaacct gcagctcatc caggtcctga tgtacgagct
    10801 ggacggcatc cgccgccagg acagcaacac cctgtggatg cagcagaccg tgctgaccgc
    10861 caccggcccc gcccacccgg cggaccggcc ggccaccgcc gaggccgccc tcaccggcag
    10921 ctggctggtc ccgctgcgcg gcggcctgtg gcgggacgtc gcgatcagcg cccgcctggg
    10981 cggctacgag atgcagtgct ccttcgccca cgaactcccg ccgttcgccg ccgccgcggc
    11041 cgccgccgac ccgaccccga gggcctgaca tgaagatctc cgtatccggt acctactccg
    11101 cgggcaagac ctccacggtc atggccctct cccactacct gggcctgccc cgcaccctcg
    11161 ccaagaccat ccgcgagatc ctgccggagg ccgtccccgg caaggcgctc gccgaggtca
    11221 cccccgccga gttcctgcac ctgatgctgc gccggcactg cggccgcgcg gtcgccgagg
    11281 cccggctcgg cgactcgttc ctctccgacg gctcctccct gcaggagtgg ctgtacggcg
    11341 ccgcccgcgt ccgccacggc atgaacccca acgccaccgc cgccaacgac ggcggcctcg
    11401 cccccgaggt cacccccgag atgcggttct tcggcgaggt cgtcgacgag tacggcaagg
    11461 cgttccgccg gcacgtgcag gagacgtacg acgtcttcat ccacctggag cacgagctgg
    11521 agatcacctc ggacggccac cgcccgatga acaagggctt ccgcgacacc atcgaccgca
    11581 tgctcctgga caccgtgcgg gagctgggca tcccgctgca ccggatcagc ggcacgatgc
    11641 ccgagcgcat ggagaagatc accgcggtgc tcggcctgac ccccgtgatg agcatcgagg
    11701 aggccctcgc cctcggcaag cgcgagtacg acgcccagga cttccgcctg gagacggaac
    11761 gggcggcagc ggcatgaacg ctctcaaccg cagacgcctc ctcgtctcca ccgcggcact
    11821 cacggccggc ctcggcctgc ccctggaggc ccacgccgcg tacggcgcgg acgcggcgac
    11881 ctcgtcggcg tacagcgagc gctcccgcac cggccgcaag ctgcgccagc gggccgccga
    11941 gcgggactac ccggccacgc tgcccgacca cccggtcaac ggcgaggagt ccctcccctc
    12001 caagatcgcc agctactcga agggcctgcc gcacaacgac ctcggcgagg tcgacgtcac
    12061 cgcgtacgcc cggctgatcc acgccctcac gaccggcaac cccgccgact tcgaggcgat
    12121 cccctcggcg ggcgagcgca agcagctcgg cccgcagggc gggctcgcct acgacctcgc
    12181 cggacccgac ccgttcaagc tggtcgtgcc gcccgccccg cgcatggaca gcgcgcaggg
    12241 cgccgccgag atggccgagc tgtactggct ggcgatgctg cgggacgtga agttcaccga
    12301 cttcgaggac tcaccgctcg ccgccgctgc ggccgccgac ctgtccacgt actccgacat
    12361 ccacgcgccc aagcagggcg gcgggatcac cccgcagacc ctgttccgcg ggaacacccc
    12421 ggccgatctg accggcccgt tcgtctcgca gttcctgctg cggaccgtcc agtacggcac
    12481 cctgcgcgtc ccgcagctgc acgacaccgt cgctcccggc gtcgaccacg gcaccgactt
    12541 cgcggagtgg ctcgccctcc agcgcggcgc ggcccgctcc acccagcggg acttcgccgg
    12601 cacccgctac ctccagacgc cccgcgacct ggcccactac acccacttcg acgtcctgta
    12661 ccaggcctac ctgaacgccg cgctgatcct gctggcgctg ccgcaggccg ccgtacagga
    12721 ccggggcaac ccctacctga cgtcgaagaa ccagatgggc ttcccgacgt acggcacccc
    12781 gcacctggtg tcactgctgg ccgaggcggc gatccgggcc atcaagcaca ccgagtacca
    12841 gcagttctac gtccaccggc gggcccgccc ggaggccttc ggcggccgta tcgaggtgca
    12901 cctgcggcgc agccccggcc gctacaccgg cctgctccac gaggagatcc tgcgctcgga
    12961 ggtgctggag cggacgcgcg cggcgaccgg ctcgtacctg ctgccgctgt ccttcccgga
    13021 gggctccccg atgagcccgt cgtaccagag cgggcacgcg acggtcgcgg gcgcgtgcac
    13081 gaccgtcctc aaggcctggt tcgacgagtc gtacgtcctc accgacccgg tcgtgccgag
    13141 cgccgacggc aagtccctgg tgccgtacac gggcgccggc caggactccc tgaccatcgg
    13201 cggcgagctg aacaagctcg cggccaacat cggcgcgggc cgggccgcct cgggcgtcca
    13261 ctaccgcacc gacaacacgg cggcgtacac gctcggcgag acgatcgccc tggagctgct
    13321 gcgcgagcag aagccgctgt tcaacgaggg tggcggcttc tccgtcacct gcttcgacgg
    13381 cacggccgtc accatctgat ccccgctcac gctgttcacg ccgaaggaag cagagaaaag
    13441 acgatgcgga agacgcaact gggaacgcag ggcctcgagg tctcggcggt cggcctcggc
    13501 tgcatgggca tgacgttcgg gtacggctcg gtcgaggagt cgcggtcgat cgccacgatc
    13561 gagcgggcgc tggagctggg ggtcgacttc ctcgactcct ccgaccacta cggccccgag
    13621 accaacgaga cgctgatcgg gcgggccatc gccggccgcc gcgacgaggt gatcgtcgcg
    13681 accaagttcg gcagctactc caccgagacg ccgccgcgga tccccgacgg ccgcccggag
    13741 accgtgcgct gggccgtcga gggctcgctg aagcggctcg gcaccgacta catcgacctt
    13801 tactaccagc accgggtcga cccgcgcgtg ccggtcgagg agaccgtcgg cgtgatggcc
    13861 gagctggtcg ccgagggcaa ggtgcgctac ctcggcctgt gcgaggcgtc ggcgcagacg
    13921 atccggcggg cgcacgccgt ccacccgatc acggccgtgc agagcgagta ctcgctgtgg
    13981 acgcgggacg ccgaggagga ggtgctgccg acgctgaagg agctgggcat cggcttcgtg
    14041 gcgtacagcc cgctcggccg cggcttcctc accggcacga tctcctcgct ggacagcctc
    14101 gcggagaacg acttccggcg gatcgcgccg cgcttccagg gcgacaacct cgacgccaac
    14161 cggggcctgc tgcgccggct gcaggagatc gccggggagc ggggcgtgac gcccgcgcag
    14221 gtcgcgctgg cgtgggtgct gcgcccggcc gagggcatcg tgccgatccc cggcacgacg
    14281 cgcccgcagc gggtggacga gaacagcgcg gcgctggaca tcgcgctgac cgacacggag
    14341 atcgcggagc tgtcggcggt gttcgcgccc ggttcggcgg tgggcgaccg ctacccggcg
    14401 ccgatgatgg cgacgctgaa cggctgagcg gtggtgtgag ggacggcgag gggtgcccct
    14461 ggtacgacgg gggcaccctt ctctgtgcct acaggtgggc ggcgttgagg atgccgcggg
    14521 tgtccacgcc ggtctcctgc tcgggccgcg ggttgtagag gacgatcagc aggtcgggga
    14581 actgcgggat gcgcatcctg gtgacgtcga agtgcagcac ccccagctcg ggatggtcga
    14641 cgaccttgac gttgacccct tcggcccgca cgtcgtgccg ggcccacagt tcggcgaact
    14701 ccgggctctt cttggtcagt tcaccgacga cgatctcgaa cccgaggtca ccgggccggg
    14761 tggtcatccc gtaccggtac tgggcgacga tccagggcgc gagttcggcc cagttgagga
    14821 cgcgggagcg caccaggggg ctggtgaaga aggtgacgag cgagttccgg tcggttttcc
    14881 ggtacccgag caggtcgtac gtcgcctggt tggcggtgac caggttccag tacgggtcga
    14941 cgacgaacgc cgggtacggc aggttgttct cggtaagacg cgccagcatg acatccactt
    15001 cgagcggctc agaactgaga ggcagcggcg gattcagacc ggccagcaca tacaggtagg
    15061 tgcgctcggc ctggtcgagc cggagcacct tggtgatggc gtcgagcacc tgcggggaca
    15121 cggagatgtt ccggccctgt tccagccact ggtaccagga ggcgctgact ccggccagga
    15181 aggcgacttc ctcgcgccgc agcccgggcg tcctccggcg tccgtagtgc gggatcccga
    15241 cgtcgccggg cgtcagccgg ccgcgccggt tgaccaggaa gtcccgcagt tccttgcggc
    15301 gacgggcctc ggaggacgag gacctgccgc tgccggtccc gaccgccccg gcggccggct
    15361 tcgcagccgc cgccccctct tccggtacct ctcccgctcc gcgcggcggg gccttggcct
    15421 ccgccgactt tccggtgatc gcgtacacga tctgcacccc ccattccggc cgcgcttccc
    15481 cagcggcggc ctgtgttcta cgtgatccgg agcgcgtgca cagcgaacgg gaacgcccct
    15541 cgcagcgaag cccccttgct tgcgtgcgac cgagccgaca ctgcacagcg cgctgccgaa
    15601 ggcacagacg aagcttcccc tcgggcatgt acaactcagg ccgaaaagac caaggtttga
    15661 ccgtgatgtt gcccacgttt cggacacggg gggcgcgggc gtggccggag ccggagttct
    15721 tgcgggggtg agggccacgg tgtcaggtgt caggtgtcag gtgcagtcca cgggatcagt
    15781 tactcaggcg tggcggtgac acgccacaag ggaggttcat actgctccgg gcggctgtcg
    15841 atgaccaggc gtcgcagcgc ctcgcgctgg gaaccgggga gattcaaggc ctccgtaagc
    15901 cgccgaaatg tcgtatgggt gacgccacgg cgccgcgctt ccgcctcgaa ccggtcgagc
    15961 tgcgccgaca ccacgtcggc gtcgatctcc acgggcggct gctcgctcaa ccgggcggcc
    16021 ttctcccgtt cgtggtcgat ctcggagatc ccgcagattt cgcgggcgta cgcctcgacc
    16081 tcgtccaagg cggcggtggt catgatggcg cgggcgaggc ggttccggtt caccgcttcg
    16141 tccaggtcga cagcgtgaac cctcggtccc tcgtccgtga gcgccacggc cggcccggca
    16201 tcgcgcacct cacagctgcc ccgaacccct cgggcggtgg cggcgagcat ggcggccacc
    16261 tcggagggat gccactccag aacgctgctc accggctcga cgtccgtcgc cgtgaaggtg
    16321 tggacgacag gcccgaggag tggccgcagc gcatccggcg gaagctcgcc atccagcccc
    16381 ggcccggcca ccagcaaccg cacggacgca ttgacctggc acgcggcggc cagggtaagg
    16441 gcatcggcga gcggactctt cagcgtcggc tcgccgccct gcgcgagaat gtccccaccg
    16501 acgtcgagga gatcgatcga ctcgggctcc aattggcgca cgacttcctc cagctgccgc
    16561 gtaacaccct caacgccccg ctgcggatcg agcagcgcga aggtgtgcgg aagctccgcc
    16621 gccagacgcg gcagcgtgga ccgggtgggc gcaacgggcc gagcactcgc gggcacggtc
    16681 cgcacggcgg aggtcagggg ggcaagcccc tcaaagtcgc tcgtgctacg cggcccgggc
    16741 acaggatcga cgaccagccg gtcccaggca taggtgagga tcacggccgg ttcctcgccg
    16801 ccgtacaggg cggcgtgcag catggcggcg gcaacggcat cgcctccacc gccggccgcg
    16861 acgatcagcc tcgtcatgac gccagcgtag gaggcaaaga gatacattta cgcgccacac
    16921 acgctgcgct ccccgctttc ccttcgcatt gagcgtgtgg cggtcggcca cgcgggacgc
    16981 ctggcccgag tcctcaacgc cctgtgacca ccacgagcaa ctggcgcaga cacgccggcg
    17041 caaggagccg ggagacgatc cccggtgagc tgttcactcc gaatgtgccg ggcggcctgc
    17101 ggcgagccga tcaccggccc ggacgacgtc atctacacgc tgacaggtcc cctggcctgc
    17161 gcagcagggg atcctccgca aagctcccgc cacgggcaag cggggccgtt tcgtcgccgt
    17221 ctcgacttgg gccggatatc cggcagaggc tgcgggtacc cgccccacag catggcccat
    17281 ggccgagtcc ggtacgcggt gacagcaacg gagaaccaga tgaaggcccg ccaaacagca
    17341 gccccgccga cgccgacgct ggtcccagcg gaggagcagc ccggcgaact cctttccggc
    17401 cgctaccgtt tgggcgccag aatcggctcg ggaggcatgg ccgacgtgta cgagggcgtc
    17461 gacacgcgcc ttcggcggtc cgtggccgtc aaggtgttcc ggcccggccc ggacccgcag
    17521 acggaggacc gtctcaccgc ggaggccgtc cttctggccc gcctgcagca cccaggactg
    17581 gtcaccgtct acgacgccgg ccgccacgac gaccgcacct acctggtcat gcaactgatc
    17641 gaaggcccca cgctgcgcgg cattctggcg tccggagcgc tgcccgagcg gcgtgtggtg
    17701 gaggtgggcg ccgccctcgc ccgggtgctg gcgtatgtcc accagtccgg cgtcgtgcac
    17761 cgggacatca aaccgtcgaa tatcctcctc gacacggccg gcgctcctca cctcgccgac
    17821 ttcggcatcg cgcgcctggc caacgccacc cgccacacgg caccggacgt actgataggg
    17881 accgccgcct acctggcacc agagcaggtc aagggccggc agatcgggcc ggccgccgac
    17941 gtctacgcgc tcggcctggt cctgctggag tgcctgaaag gggaactgga gtaccagggc
    18001 acccccttgg aggcgaccgt cgcccgcctg caccgcccac ccgacgtccc cgcctggctc
    18061 cccccggaac tcgcggccct gctgcgggcc atgaccgccc aggaccccga ggcccgcccg
    18121 gacgccgagc agtgcgcaca agccctcgcc tcccggcaca ccgggcctgc cccctacccc
    18181 ctgccgctcc cggcgccctc cgggtcggcc cttccgacgc cgccggccac tccccccggg
    18241 acgaaggagc acatacgctc ccaggatgcg gtcgtcaccc ggcgcggcct ccccggcggc
    18301 acgcgccacg gccgtcgtct ggcggcgggc acggccctgg ccctctccgt ggccctgggc
    18361 gcgactcttg ccgccacatc gagcaccagc gaaagcgccg accggaacgc agggacaccc
    18421 gccacaaccc ccgcacaccc gccctccggt accgcgacag cgaagagcgg acccggcgcc
    18481 cctcccccca cccggtctca cggcactcag cccccttccg ggacatccgg tgcgtccgat
    18541 cccgcggccg cgacgaccgg ctcccacgcc cagcccgctt ccaggacact cggcgcccct
    18601 gatccggcgg ccgccccggg ttcgagccgc ggcgcctccg caccgcacac gagtcaccgg
    18661 ccgcccggat cggcgtcacc atccacgccg accgcgaccg gcgccaccgg cccgacccag
    18721 acgacacctg cggcatcgcc gaccaccggc acggcgcccg cgtcaccgcg gccctcgaag
    18781 ggcaaggcca ccggcgcacc ccccaagccg agcccgacgc ggtagaggcc gacccgcccg
    18841 gggcacaccc gcgtcaggag cccgccccgg agcgacggcc tacagacagc gaaaagcccc
    18901 ctccgcggag aacccgcagg cagggggcca atgacatggg cgtctacttc ttcttaccct
    18961 gggtcttgcc ggggatcttg atgagctgcg tttctgctgg ttagcgccgt attagaacgc
    19021 ggctgcggag tcactctttg tcgttgttgg ctgctgtcga gcagcctcgg acggccccag
    19081 gacggcccag agccgggctc agtgttcaga cacagagtgc ccaggccacg caaagcatca
    19141 cgtcgtacag ggataggcct cgtatctatg caacaaggtc gagggagcca tacgcgacgt
    19201 cggcgaagct atcccggact gcctgaaaac gctccagcag tgggtctcgg acgaagccac
    19261 cgatcatctc gtcccagaac gcaacacagt tggccacttc cattacgtgc ttgacctgtt
    19321 ccgcatccaa ggcgtgactc tcctgcaagg tgaactccaa gaggtcgagc ttctcccacc
    19381 gctcctcatc ctccagacgc ccccactcgc ataagagccc ccaggccacg tgcgcggagt
    19441 tgtggtgtgg gtcctggcac cactcggcgt tgcgagggca ccaagcgtcc tccagggcac
    19501 tgatcgccga tctcagcaca gctctgcgaa gtgccaactt ctccaattgg gcgcactgct
    19561 cggccaccct ctccgcttga ctgagaactg gcggcggccc cagaacggca acgccagccc
    19621 gggcctgcac cacggcggtc gccttctgat cgagcagttc tcgccgtgaa gcgcgaggca
    19681 tgtctggtag cgcggtgacg atccggacga agacgtctac cgcactcagg aagtcggcat
    19741 aggccgagcg acgtgcactc tccaaggact cctcccgtaa cgcacgctcc tggagttggg
    19801 cagccgccac tgtggcctga gattgatcaa ggcctgccgc caccgtcgca ttagcggcct
    19861 tgtctgcgct acgtctggtc cagtgggcag cgagcagagt ggcaggcacc gtgatgaggg
    19921 tggttagagc gctcgttgcc gctacagctt gttctagttg cacgagacgc atagtggtgt
    19981 cagagcctgt cagccgcggt aaaaaggtga atcagccgag gatgaccgtc gcgccatgct
    20041 aggtccctca tggggagaag cgccccatct tgcctgaccg ccgcccctgg ggggaaaccc
    20101 gtatggttcc ggccctctga cctggccttt cgccgcagac ggccgcgaca cacctgtcac
    20161 tgccggtcgc cgttggtcga cctcgggcac cctcgcacgg cccagggacg gcccagggct
    20221 gagccgagcc gggagcgggg atcaaaagct gctgcgccgc accgacaccg gtcactcaag
    20281 tggcaaggga gcgactggga gctgttcctt gtggagccac ctgaaggtcc ggtccggttc
    20341 gaggtgggcc tctccccagt gaatgacgtg gatgccgttc tccgcgtcgg ccgtgaagaa
    20401 cacgcagacg agcctcgtgg aggcccccag ctcctcgaat gcctcgtgca ggcccaggta
    20461 ctcctccgtc gccaggccag catcgacctc gaacagcccg tctggagcct gcggcccgtg
    20521 ggcccggaac agccgctgcc gggtggggga cgcgttggca ggcaaccgcg cacgatccag
    20581 gggccgcggc ttgtctgcgt acctgaaggg gaagagcgcg tgctcgttga tcacggcgta
    20641 ctcgtacccc cggacatccc gcacggactc ccccagctcc cgcgccgcgt ccgccaggcc
    20701 ctcacgcaca gccccggcaa gggcgacacc gtaggggctc cgcttcttca gccctgccgc
    20761 tatgtgcgcc gcatgagcct tggcgtgcgc cctggccagt tgtagcggaa cagcagcggc
    20821 gagcgcgccg gcatgccgcc cgaaccgctc aaccgcccag tccgacggtc ctaccggctc
    20881 acgaccccgc acagacatga agcgcccccc ctcgcccgat cacccgcctt tcaactgtgt
    20941 gacacgtaca cgaacggcac acaagggagc gatctagcca cggcatcgcg cagacaacgc
    21001 tgctgggaga gcgcgcaccc tatcttcgcc tgtatgttcg cgaacaggta gtcatcacaa
    21061 cgggcgca
//
