LOCUS NZ_BNBR01000006 21068 bp DNA linear CON 02-SEP-2024 DEFINITION Streptomyces griseosporeus strain JCM 4766 sequence06, whole genome shotgun sequence. ACCESSION NZ_BNBR01000006 VERSION NZ_BNBR01000006.1 KEYWORDS WGS; RefSeq; STANDARD_DRAFT. SOURCE Streptomyces griseosporeus ORGANISM Streptomyces griseosporeus Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Wu,L. and Ma,J. TITLE The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing project: providing services to taxonomists for standard genome sequencing and annotation JOURNAL Int J Syst Evol Microbiol 69 (4), 895-898 (2019) PUBMED 30832757 REFERENCE 2 (bases 1 to 563512) AUTHORS Sun,Q. and Ohkuma,M. TITLE Direct Submission JOURNAL Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL :http://www.wdcm.org/ COMMENT ##Genome-Assembly-Data-START## Assembly Method :: gcType assembly pipeline Genome Coverage :: 112X Sequencing Technology :: Illumina HiSeq X Ten ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_014656055.1-RS_2024_09_02 Annotation Date :: 09/02/2024 05:04:52 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 7,365 CDSs (total) :: 7,282 Genes (coding) :: 7,186 CDSs (with protein) :: 7,186 Genes (RNA) :: 83 rRNAs :: 2, 4, 2 (5S, 16S, 23S) complete rRNAs :: 2 (5S) partial rRNAs :: 4, 2 (16S, 23S) tRNAs :: 72 ncRNAs :: 3 Pseudo Genes (total) :: 96 CDSs (without protein) :: 96 Pseudo Genes (ambiguous residues) :: 0 of 96 Pseudo Genes (frameshifted) :: 41 of 96 Pseudo Genes (incomplete) :: 61 of 96 Pseudo Genes (internal stop) :: 11 of 96 Pseudo Genes (multiple problems) :: 15 of 96 CRISPR Arrays :: 1 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 17:46:46 NOTE :: This is a single region extracted from a larger record! Orig. start :: 447052 Orig. end :: 468120 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to BNBR01000006.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..21068 /candidate_cluster_numbers="1" /contig_edge="False" /product="furan" /region_number="1" /rules="(mmyO or AvrD)" /tool="antismash" cand_cluster 1..21068 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(mmyO or AvrD)" /kind="single" /product="furan" /protoclusters="1" /tool="antismash" protocluster 1..21068 /aStool="rule-based-clusters" /category="other" /contig_edge="False" /core_location="[10000:11068](+)" /cutoff="20000" /detection_rule="(mmyO or AvrD)" /neighbourhood="10000" /product="furan" /protocluster_number="1" /tool="antismash" proto_core 10001..11068 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(mmyO or AvrD)" /neighbourhood="10000" /product="furan" /protocluster_number="1" gene complement(259..741) /locus_tag="IE308_RS28625" /old_locus_tag="GCM10018783_58090" CDS complement(259..741) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014136563.1" /locus_tag="IE308_RS28625" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58090" /product="CarD family transcriptional regulator" /protein_id="WP_003953493.1" /transl_table=11 /translation="MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLT VRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKV AEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS" misc_feature 795..809 /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 18.47" /tool="antismash" gene 1398..2057 /locus_tag="IE308_RS28630" /old_locus_tag="GCM10018783_58100" CDS 1398..2057 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020130320.1" /locus_tag="IE308_RS28630" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58100" /product="DUF461 domain-containing protein" /protein_id="WP_190220129.1" /transl_table=11 /translation="MSSSLRRGALAASVIAVSIASLAACGAGNDSQTLQIKPDNAATSV GDIKIQNAVVVTQPERESTGPAAISATVFNTGDTAQTLDAIKVAGVDQPAEIKAPKGGK LTVPAGGSVVIGGKGNAVATVESGHEAVRDGNVQKVTFTFSKTGDVALDAFVVPAESYF SEYGPSEVPSASAEAPSGKPSESASGKPSASASGTPTDQASASASASASASESAGH" gene complement(2141..2821) /locus_tag="IE308_RS28635" /old_locus_tag="GCM10018783_58110" CDS complement(2141..2821) /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1008: response regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008410337.1" /locus_tag="IE308_RS28635" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58110" /product="response regulator transcription factor" /protein_id="WP_190220130.1" /transl_table=11 /translation="MTRVLVVEDEESFSDALSYMLRKEGFEVAVAATGPDGLDEFERNG ADLVLLDLMLPGLPGTEVCRQLRGRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFS SRELVARIRAVLRRRGEPEEVTPTALEAGPVRMDVDRHVVTVGGSKVDLPLKEFDLLEM LLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGY KFEP" gene complement(2818..4110) /locus_tag="IE308_RS28640" /old_locus_tag="GCM10018783_58120" CDS complement(2818..4110) /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1003: sensor histidine kinase" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019072375.1" /locus_tag="IE308_RS28640" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58120" /product="cell wall metabolism sensor histidine kinase WalK" /protein_id="WP_110628910.1" /transl_table=11 /translation="MDVNAAVAAAAAIAGVLTGVIAMLAFRWSERELKRPTRTSLHTDP VLPPGVDTVLSVLRSSAVVLDEADGVVKASSAAYALGLVRGGKLAVEPMLQMARDTRRD GEIRQVELDLPRRGTGRGEALAVSARVAPLGSRLVLLLVEDLTEARRIEAVRRDFVANV SHELKTPVGALSLLSEAVMDASDDPEAVQRFAGRMQIEATRLTNLVQELIDLSRVQNDD PLEDAEPVGVDELVNEAIDRCRHQAGTKNITMTAGGTADLRVWGNRGQLAAALGNLVEN AVNYSPARTRVGIAARRVTAPGGDMIEIAVTDQGIGISDKDKERIFERFYRVDPARSRA TGGTGLGLAIVKHVVASHGGEVTVWSAEGQGSTFTLRLPEAGAARDRDRALQHPALDDE AGTRRTTSASSTASPPDPTAYETLSAPEVLP" misc_feature complement(4097..4108) /note="TFBS match to AfsR, Pleiotropic regulatory for antibiotic production, confidence: strong, score: 20.58" /tool="antismash" gene 4348..5037 /gene="phoU" /locus_tag="IE308_RS28645" /old_locus_tag="GCM10018783_58130" CDS 4348..5037 /GO_process="GO:0006817 - phosphate ion transport [Evidence IEA]" /GO_process="GO:0030643 - intracellular phosphate ion homeostasis [Evidence IEA]" /GO_process="GO:0045936 - negative regulation of phosphate metabolic process [Evidence IEA]" /codon_start=1 /gene="phoU" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005476809.1" /locus_tag="IE308_RS28645" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58130" /product="phosphate signaling complex protein PhoU" /protein_id="WP_110628911.1" /transl_table=11 /translation="MRDAYHEELDSIGDGLVEMARLVGSAIGRATTAILDADLKLAESV IEADQKVDELQHGLEARAIALLARQQPVATDLRIVVTSLRMSADLERSGDLAQHVAKLA RLRFPERAVPQDLHATILEMGQLAQRLMAKAAEVIITKDVDLALQLEQDDDAMDLLHRT LFQHLIDERWKHGIETAVDVTLLGRYYERYADHAVAVAKRVVYLVTGEHADELQQDTQT VTGVEGA" gene 5480..5728 /locus_tag="IE308_RS28650" /old_locus_tag="GCM10018783_58150" CDS 5480..5728 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007455570.1" /locus_tag="IE308_RS28650" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58150" /product="SCO4226 family nickel-binding protein" /protein_id="WP_110628913.1" /transl_table=11 /translation="MARYMDIHRGMKGITADQLKQAHEADLAIEKDEGVHFERAWADPE TGTVYCLSEAPSAEAVQRIHERAGHKADEVHAVPLQV" misc_feature 5808..5823 /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2, activator of antibiotic production, confidence: medium, score: 17.28" /tool="antismash" misc_feature 5878..5896 /note="TFBS match to DmdR1, Iron(II)-dependent repressor, confidence: medium, score: 31.03" /tool="antismash" gene 5927..6508 /locus_tag="IE308_RS28655" /old_locus_tag="GCM10018783_58160" CDS 5927..6508 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="IE308_RS28655" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="GCM10018783_58160" /product="hypothetical protein" /protein_id="WP_229909201.1" /transl_table=11 /translation="MSVLPSETSVPPSAAATRRLGLYDTWWTVAAGALAACLGIAACAW VSLHLHADAALHSAALFLHLAALVLGFGAVLVADYYALLFLTGRCSLRDALTTTGRLHA PIWAGLVGLVASGALLHPDLGSVLTRVKLGLVLALTLNGLQAGVLNRRMRDETGTPLTG RLLAWGAGTALVSQVCWWGAVLIGFRNSQR" gene complement(6570..7499) /locus_tag="IE308_RS28660" /old_locus_tag="GCM10018783_58170" CDS complement(6570..7499) /EC_number="1.-.-.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /NRPS_PKS="Domain: PKS_ER (17-307). E-value: 3.8e-52. Score: 169.3. Matches aSDomain: nrpspksdomains_IE308_RS28660_PKS_ER.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_N" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_zinc_N" /gene_functions="biosynthetic-additional (smcogs) SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017237538.1" /locus_tag="IE308_RS28660" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58170" /product="NADP-dependent oxidoreductase" /protein_id="WP_110628914.1" /sec_met_domain="ADH_N (E-value: 1.8e-09, bitscore: 32.5, seeds: 66, tool: rule-based-clusters)" /sec_met_domain="ADH_zinc_N (E-value: 3.5e-16, bitscore: 54.4, seeds: 86, tool: rule-based-clusters)" /transl_table=11 /translation="MRAISQQRYGGLDVLQEVDLPVPQPGPGQILVRVRAAGVNPTDWK NRARRVWFEQPPRVLGWDLSGTVEQVGFGVTLFRPGDEVFGMLPYPHGVGSHAEYAVGP ARAFAAKPDEIDHVQAGALPLAALTAYQALVDTADVRPGQHVLIHAAAGGVGHLAVQIA KHLGARVTGTASAAKHDFVRSLGADEVVDYRTTDFRDVVRDVDVALVPMTDATRIRTVE VLRPGGTLVALLPGATEEELAACADRGVRYAAMLVEHDHTGMTAVADLARKGALRAHVQ EVIPLSEAARAHALGEEGHVTGKLVLVP" aSDomain complement(6579..7448) /ASF="ER configuration inconclusive" /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE308_RS28660_PKS_ER.1" /evalue="3.80E-52" /label="IE308_RS28660_PKS_ER.1" /locus_tag="IE308_RS28660" /protein_end="307" /protein_start="17" /score="169.3" /tool="antismash" /translation="VDLPVPQPGPGQILVRVRAAGVNPTDWKNRARRVWFEQPPRVLGW DLSGTVEQVGFGVTLFRPGDEVFGMLPYPHGVGSHAEYAVGPARAFAAKPDEIDHVQAG ALPLAALTAYQALVDTADVRPGQHVLIHAAAGGVGHLAVQIAKHLGARVTGTASAAKHD FVRSLGADEVVDYRTTDFRDVVRDVDVALVPMTDATRIRTVEVLRPGGTLVALLPGATE EELAACADRGVRYAAMLVEHDHTGMTAVADLARKGALRAHVQEVIPLSEAARAHALGEE GHVTGKLVL" CDS_motif complement(7011..7073) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE308_RS28660_0001" /evalue="3.50E-07" /label="PKSI-ER_m5" /locus_tag="IE308_RS28660" /protein_end="163" /protein_start="142" /score="22.7" /tool="antismash" /translation="GQHVLIHAAAGGVGHLAVQIA" gene 7630..8973 /locus_tag="IE308_RS28665" /old_locus_tag="GCM10018783_58180" CDS 7630..8973 /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /NRPS_PKS="Domain: AMP-binding (7-355). E-value: 1.3e-53. Score: 173.9. Matches aSDomain: nrpspksdomains_IE308_RS28665_AMP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014672598.1" /locus_tag="IE308_RS28665" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58180" /product="class I adenylate-forming enzyme family protein" /protein_id="WP_190220131.1" /sec_met_domain="AMP-binding (E-value: 8e-47, bitscore: 154.6, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MIQSLTEALRSHEDREAIIFHGQSTSYRTLLTGVEKWRARLNEYG IRPGQVVALESAYSPQACAALVALIETGAIIVPLVTLPDAKRAEFHEIAEVEAVITLDG SEAGWTITTTGRTAGHELFTALRRERHPGLVLFSSGTTGRSKASVLDFTKVLARYRGGR PARTLSFLNLDHIGGVNTLLHTLVHGGAVVTVAERTPDSVFAAIEAHRVEVLPTTPTFL TMAVVSGAVRRHDASSLRLVTYGTEPMPEQTLLAVHEALPEVRLKQTYGLSELGILPTR SKDDSSLWVRLGGSGFDYKIVDGVLWVRSEMAMLGYLNAPAPFDEDGYFNTQDMVVVEG EYLRILGRRSEIINVGGEKVYPAEVENVVLEAGNIADVTVSGRPSPVTGMVVQATVKLV RPEDEDAVAARVQDHCAARLEPYKVPLIVQVSQADQHSDRFKKLRSAA" aSDomain 7651..8694 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE308_RS28665_AMP-binding.1" /evalue="1.30E-53" /label="IE308_RS28665_AMP-binding.1" /locus_tag="IE308_RS28665" /protein_end="355" /protein_start="7" /score="173.9" /specificity="substrate consensus: X" /tool="antismash" /translation="ALRSHEDREAIIFHGQSTSYRTLLTGVEKWRARLNEYGIRPGQVV ALESAYSPQACAALVALIETGAIIVPLVTLPDAKRAEFHEIAEVEAVITLDGSEAGWTI TTTGRTAGHELFTALRRERHPGLVLFSSGTTGRSKASVLDFTKVLARYRGGRPARTLSF LNLDHIGGVNTLLHTLVHGGAVVTVAERTPDSVFAAIEAHRVEVLPTTPTFLTMAVVSG AVRRHDASSLRLVTYGTEPMPEQTLLAVHEALPEVRLKQTYGLSELGILPTRSKDDSSL WVRLGGSGFDYKIVDGVLWVRSEMAMLGYLNAPAPFDEDGYFNTQDMVVVEGEYLRILG RRSEIINV" CDS_motif 8032..8079 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE308_RS28665_0001" /evalue="2.40E-03" /label="NRPS-A_a3" /locus_tag="IE308_RS28665" /protein_end="150" /protein_start="134" /score="11.0" /tool="antismash" /translation="VLFSSGTTGRSKASVL" gene 8970..9707 /locus_tag="IE308_RS28670" /old_locus_tag="GCM10018783_58190" CDS 8970..9707 /EC_number="1.1.1.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]" /NRPS_PKS="Domain: PKS_KR (6-175). E-value: 1.8e-12. Score: 39.5. Matches aSDomain: nrpspksdomains_IE308_RS28670_PKS_KR.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001: short-chain dehydrogenase/reductase SDR" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018520428.1" /locus_tag="IE308_RS28670" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58190" /product="SDR family NAD(P)-dependent oxidoreductase" /protein_id="WP_110628916.1" /sec_met_domain="adh_short (E-value: 2e-34, bitscore: 114.1, seeds: 230, tool: rule-based-clusters)" /transl_table=11 /translation="MSDTTAGVALVSGGSRGLGQTLVTRLLAEGWQVATFSRTAGDFVE QTLKAEPDRFFWTEADLLRPETVRAAGKAAIDRFGRIDLLVNNAGVLEQGLFVTMPPRR AEDLVTANLTSPVVLAQVAARSMVASGGGQIINISSVNAVRGYRGVAAYSAAKAGLDGL THSLARELGPAGIRVNTVVPGFFDSDMTEGVGPEYRERIQRRTPLGRLGDRAEVADAVL FLASPRAGFVTGQRLVIDGGITC" aSDomain 8988..9494 /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE308_RS28670_PKS_KR.1" /evalue="1.80E-12" /label="IE308_RS28670_PKS_KR.1" /locus_tag="IE308_RS28670" /protein_end="175" /protein_start="6" /score="39.5" /specificity="KR activity: inactive" /specificity="KR stereochemistry: C2" /tool="antismash" /translation="GVALVSGGSRGLGQTLVTRLLAEGWQVATFSRTAGDFVEQTLKAE PDRFFWTEADLLRPETVRAAGKAAIDRFGRIDLLVNNAGVLEQGLFVTMPPRRAEDLVT ANLTSPVVLAQVAARSMVASGGGQIINISSVNAVRGYRGVAAYSAAKAGLDGLTHSLAR ELGPAG" CDS_motif 8997..9053 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE308_RS28670_0001" /evalue="1.10E-02" /label="PKSI-KR_m1" /locus_tag="IE308_RS28670" /protein_end="28" /protein_start="9" /score="8.5" /tool="antismash" /translation="LVSGGSRGLGQTLVTRLLA" CDS_motif 9324..9377 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE308_RS28670_0002" /evalue="4.30E+00" /label="PKSI-KR_m1" /locus_tag="IE308_RS28670" /protein_end="136" /protein_start="118" /score="0.2" /tool="antismash" /translation="LAQVAARSMVASGGGQII" CDS_motif 9381..9467 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE308_RS28670_0003" /evalue="3.80E-06" /label="PKSI-KR_m4" /locus_tag="IE308_RS28670" /protein_end="166" /protein_start="137" /score="19.4" /tool="antismash" /translation="ISSVNAVRGYRGVAAYSAAKAGLDGLTHS" gene 9701..9997 /locus_tag="IE308_RS28675" /old_locus_tag="GCM10018783_58200" CDS 9701..9997 /GO_function="GO:0000035 - acyl binding [Evidence IEA]" /GO_function="GO:0000036 - acyl carrier activity [Evidence IEA]" /GO_process="GO:0006633 - fatty acid biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: PP-binding (30-86). E-value: 5.7e-11. Score: 34.6. Matches aSDomain: nrpspksdomains_IE308_RS28675_PP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018102210.1" /locus_tag="IE308_RS28675" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58200" /product="acyl carrier protein" /protein_id="WP_190220132.1" /sec_met_domain="PP-binding (E-value: 3.6e-11, bitscore: 38.4, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MLSNTLTDTRTTDVQATVVQEIVAILDEDTVDELGELTADTELSA LGLNSLAFARLIIKLERALGVDPFSQGGDFVALRTVGALAGAYEQALSARTEA" aSDomain 9791..9958 /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE308_RS28675_PP-binding.1" /evalue="5.70E-11" /label="IE308_RS28675_PP-binding.1" /locus_tag="IE308_RS28675" /protein_end="86" /protein_start="30" /score="34.6" /tool="antismash" /translation="VDELGELTADTELSALGLNSLAFARLIIKLERALGVDPFSQGGDF VALRTVGALAG" gene 10001..11068 /locus_tag="IE308_RS28680" /old_locus_tag="GCM10018783_58210" CDS 10001..11068 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) furan: AvrD" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014672595.1" /locus_tag="IE308_RS28680" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58210" /product="AvrD family protein" /protein_id="WP_190220133.1" /sec_met_domain="AvrD (E-value: 7e-104, bitscore: 342.7, seeds: 6, tool: rule-based-clusters)" /transl_table=11 /translation="MSTATTTLLHLPSVDDYLGPSATRFFSAGYRRAEHTVDDLRISTG TATGDRPGVSARVSLAYPRDWSKKKASTDLFPHVSTVDMLVIGIQLCEAYLAHVHRLGA ADRRRARVRKITLKAGTTPQEELTGLTAGAELRRTHQDPAAAGGHVSTFTAHVGVMTAR YEIEHAVADEPRGEGTYASLDDVLGPAAARYYGDGFKLRSHTVTDVRADVAELTATATV AAHDLPGYADAVTAGLDGERLAGELTPVDCFVTNLQLIQVLMYELDGIRRQDSNTLWMQ QTVLTATGPAHPADRPATAEAALTGSWLVPLRGGLWRDVAISARLGGYEMQCSFAHELP PFAAAAAAADPTPRA" misc_feature 10118..10120 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 11070..11777 /locus_tag="IE308_RS28685" /old_locus_tag="GCM10018783_58220" CDS 11070..11777 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020135627.1" /locus_tag="IE308_RS28685" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58220" /product="AAA family ATPase" /protein_id="WP_110628919.1" /transl_table=11 /translation="MKISVSGTYSAGKTSTVMALSHYLGLPRTLAKTIREILPEAVPGK ALAEVTPAEFLHLMLRRHCGRAVAEARLGDSFLSDGSSLQEWLYGAARVRHGMNPNATA ANDGGLAPEVTPEMRFFGEVVDEYGKAFRRHVQETYDVFIHLEHELEITSDGHRPMNKG FRDTIDRMLLDTVRELGIPLHRISGTMPERMEKITAVLGLTPVMSIEEALALGKREYDA QDFRLETERAAAA" gene 11774..13399 /locus_tag="IE308_RS28690" /old_locus_tag="GCM10018783_58230" CDS 11774..13399 /EC_number="1.11.1.-" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010040286.1" /locus_tag="IE308_RS28690" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58230" /product="vanadium-dependent haloperoxidase" /protein_id="WP_229909203.1" /transl_table=11 /translation="MNALNRRRLLVSTAALTAGLGLPLEAHAAYGADAATSSAYSERSR TGRKLRQRAAERDYPATLPDHPVNGEESLPSKIASYSKGLPHNDLGEVDVTAYARLIHA LTTGNPADFEAIPSAGERKQLGPQGGLAYDLAGPDPFKLVVPPAPRMDSAQGAAEMAEL YWLAMLRDVKFTDFEDSPLAAAAAADLSTYSDIHAPKQGGGITPQTLFRGNTPADLTGP FVSQFLLRTVQYGTLRVPQLHDTVAPGVDHGTDFAEWLALQRGAARSTQRDFAGTRYLQ TPRDLAHYTHFDVLYQAYLNAALILLALPQAAVQDRGNPYLTSKNQMGFPTYGTPHLVS LLAEAAIRAIKHTEYQQFYVHRRARPEAFGGRIEVHLRRSPGRYTGLLHEEILRSEVLE RTRAATGSYLLPLSFPEGSPMSPSYQSGHATVAGACTTVLKAWFDESYVLTDPVVPSAD GKSLVPYTGAGQDSLTIGGELNKLAANIGAGRAASGVHYRTDNTAAYTLGETIALELLR EQKPLFNEGGGFSVTCFDGTAVTI" gene 13444..14427 /locus_tag="IE308_RS28695" /old_locus_tag="GCM10018783_58240" CDS 13444..14427 /EC_number="1.1.1.-" /GO_function="GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1039: aldo/keto reductase family oxidoreductase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018521802.1" /locus_tag="IE308_RS28695" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58240" /product="aldo/keto reductase" /protein_id="WP_190220134.1" /transl_table=11 /translation="MRKTQLGTQGLEVSAVGLGCMGMTFGYGSVEESRSIATIERALEL GVDFLDSSDHYGPETNETLIGRAIAGRRDEVIVATKFGSYSTETPPRIPDGRPETVRWA VEGSLKRLGTDYIDLYYQHRVDPRVPVEETVGVMAELVAEGKVRYLGLCEASAQTIRRA HAVHPITAVQSEYSLWTRDAEEEVLPTLKELGIGFVAYSPLGRGFLTGTISSLDSLAEN DFRRIAPRFQGDNLDANRGLLRRLQEIAGERGVTPAQVALAWVLRPAEGIVPIPGTTRP QRVDENSAALDIALTDTEIAELSAVFAPGSAVGDRYPAPMMATLNG" gene complement(14489..15457) /locus_tag="IE308_RS28700" /old_locus_tag="GCM10018783_58250" CDS complement(14489..15457) /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: protein motif:HMM:NF037627.5" /locus_tag="IE308_RS28700" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58250" /product="helix-turn-helix transcriptional regulator" /protein_id="WP_190220135.1" /transl_table=11 /translation="MQIVYAITGKSAEAKAPPRGAGEVPEEGAAAAKPAAGAVGTGSGR SSSSEARRRKELRDFLVNRRGRLTPGDVGIPHYGRRRTPGLRREEVAFLAGVSASWYQW LEQGRNISVSPQVLDAITKVLRLDQAERTYLYVLAGLNPPLPLSSEPLEVDVMLARLTE NNLPYPAFVVDPYWNLVTANQATYDLLGYRKTDRNSLVTFFTSPLVRSRVLNWAELAPW IVAQYRYGMTTRPGDLGFEIVVGELTKKSPEFAELWARHDVRAEGVNVKVVDHPELGVL HFDVTRMRIPQFPDLLIVLYNPRPEQETGVDTRGILNAAHL" gene complement(15780..16877) /locus_tag="IE308_RS28705" /old_locus_tag="GCM10018783_58260" CDS complement(15780..16877) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003992960.1" /locus_tag="IE308_RS28705" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58260" /product="DUF1152 domain-containing protein" /protein_id="WP_190220136.1" /transl_table=11 /translation="MTRLIVAAGGGGDAVAAAMLHAALYGGEEPAVILTYAWDRLVVDP VPGPRSTSDFEGLAPLTSAVRTVPASARPVAPTRSTLPRLAAELPHTFALLDPQRGVEG VTRQLEEVVRQLEPESIDLLDVGGDILAQGGEPTLKSPLADALTLAAACQVNASVRLLV AGPGLDGELPPDALRPLLGPVVHTFTATDVEPVSSVLEWHPSEVAAMLAATARGVRGSC EVRDAGPAVALTDEGPRVHAVDLDEAVNRNRLARAIMTTAALDEVEAYAREICGISEID HEREKAARLSEQPPVEIDADVVSAQLDRFEAEARRRGVTHTTFRRLTEALNLPGSQREA LRRLVIDSRPEQYEPPLWRVTATPE" gene 17437..18825 /locus_tag="IE308_RS28710" /old_locus_tag="GCM10018783_58270" CDS 17437..18825 /EC_number="2.7.11.1" /GO_function="GO:0004672 - protein kinase activity [Evidence IEA]" /GO_process="GO:0006468 - protein phosphorylation [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Pkinase" /gene_functions="regulatory (smcogs) SMCOG1030: serine/threonine protein kinase" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020124096.1" /locus_tag="IE308_RS28710" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58270" /product="serine/threonine-protein kinase" /protein_id="WP_190220137.1" /sec_met_domain="Pkinase (E-value: 5.5e-49, bitscore: 161.8, seeds: 54, tool: rule-based-clusters)" /transl_table=11 /translation="MADVYEGVDTRLRRSVAVKVFRPGPDPQTEDRLTAEAVLLARLQH PGLVTVYDAGRHDDRTYLVMQLIEGPTLRGILASGALPERRVVEVGAALARVLAYVHQS GVVHRDIKPSNILLDTAGAPHLADFGIARLANATRHTAPDVLIGTAAYLAPEQVKGRQI GPAADVYALGLVLLECLKGELEYQGTPLEATVARLHRPPDVPAWLPPELAALLRAMTAQ DPEARPDAEQCAQALASRHTGPAPYPLPLPAPSGSALPTPPATPPGTKEHIRSQDAVVT RRGLPGGTRHGRRLAAGTALALSVALGATLAATSSTSESADRNAGTPATTPAHPPSGTA TAKSGPGAPPPTRSHGTQPPSGTSGASDPAAATTGSHAQPASRTLGAPDPAAAPGSSRG ASAPHTSHRPPGSASPSTPTATGATGPTQTTPAASPTTGTAPASPRPSKGKATGAPPKP SPTR" gene complement(19166..19765) /locus_tag="IE308_RS28715" /old_locus_tag="GCM10018783_58280" CDS complement(19166..19765) /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="IE308_RS28715" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="GCM10018783_58280" /product="hypothetical protein" /protein_id="WP_190220138.1" /transl_table=11 /translation="MESARRSAYADFLSAVDVFVRIVTALPDMPRASRRELLDQKATAV VQARAGVAVLGPPPVLSQAERVAEQCAQLEKLALRRAVLRSAISALEDAWCPRNAEWCQ DPHHNSAHVAWGLLCEWGRLEDEERWEKLDLLEFTLQESHALDAEQVKHVMEVANCVAF WDEMIGGFVRDPLLERFQAVRDSFADVAYGSLDLVA" misc_feature complement(19412..19414) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene complement(20272..20898) /locus_tag="IE308_RS28720" /old_locus_tag="GCM10018783_58290" CDS complement(20272..20898) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004986492.1" /locus_tag="IE308_RS28720" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018783_58290" /product="hypothetical protein" /protein_id="WP_190220139.1" /transl_table=11 /translation="MSVRGREPVGPSDWAVERFGRHAGALAAAVPLQLARAHAKAHAAH IAAGLKKRSPYGVALAGAVREGLADAARELGESVRDVRGYEYAVINEHALFPFRYADKP RPLDRARLPANASPTRQRLFRAHGPQAPDGLFEVDAGLATEEYLGLHEAFEELGASTRL VCVFFTADAENGIHVIHWGEAHLEPDRTFRWLHKEQLPVAPLPLE" misc_feature 21026..21041 /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 20.88" /tool="antismash" ORIGIN 1 gccggacggg acacgttcga ccggaccctt ccgtgaccat ggtcgaaccg gttgcccggc 61 cccggcacac aggatcgggg gaaatctccc cgttgtacgg cacggacgcg tcgtctctgc 121 gcaggaagtc gtgactgcgt acgaacatgc cgcagcgccc ggcgacggat tgtcacgtca 181 tcgggcaccg cggcatcgcc atgtcagcgc atgtaggtca tgtacgtcat ggcaggtact 241 gagcggcctg cgccggcgtc aggacgcgag gacctcgtcg agcagggcct cggccttgtc 301 ctcgttcgtg ttctccgcga gggccagctc gctcaccagg atctgccggg ccttggcgag 361 catgcgcttc tcacctgcgg agagtccgcg ctcgcgctcg cgacgccaca ggtcgcgcac 421 gacttccgcg accttgatga catcgccgga ggcgagcttc tccagatttg ccttgtagcg 481 acgcgaccag ttcgtgggct cctcggcgta cggcgcgcgc agcacctcga agacccggtc 541 cagcccgtcc tgaccgacca catcacgcac gccgacgaac tccgcattgt ccgctggcac 601 acgtaccgtc aggtcaccct gggcgacctt cagcaccaag taggtcttgt ccacgccttt 661 gatctggcga gtttcgatgg cctcgatcag cgcggccccg tgatggggat agaccacggt 721 gtcgccaacc ttgaacgtca tgtgacaggt accccttccg tggctatcca gggtaacacg 781 gatacggcgt cttctgaatg gcgttttcgc aggtcagggc atatctcggg gcttgacaac 841 agcaacagga acgtgctgcg cgggccgagc ggaagcgggt attcgcaggt cggagcggct 901 gtgcggggga ggtgaaacgc gtacgttaca cgcatccgga ggctccctca ggcggccgaa 961 cgtccccaaa tgtccggttc cggatgtgcg acttccgcta ctccgttcgg tgtcccggag 1021 gtggatacgc gccgaatccg gaattgatca cgggcaccgc acaaggccgg acgctacccg 1081 cgttgatcaa ttcccggaca gcggcaccgg agggccgcgc attccttcac ggaaaatccg 1141 cgcgacagcg caggtgagac cggcggcgac ttatgtgaat ggcggaccgg tggccggtca 1201 aagtgactga tgggtcagtt gtggcggagg tgatcgcgcc gcctcgcgcg cctgcacgag 1261 ggaagccgga acgcccgggg gagggtcggg tgcggcggcc gggggacggc tcggtaacct 1321 aaggccgctg acagaccctt agggcggctt tgtgacacgc gccgctctgt ccctgcgttc 1381 aaggagttgc cgccgccgtg agcagcagcc ttcgacgcgg cgccctcgcc gcctccgtca 1441 tcgccgtctc catcgcctcg ctggccgcct gcggcgccgg gaacgactcg cagacgctcc 1501 agatcaagcc ggacaacgcg gccaccagcg tcggcgacat caagatccag aacgccgtgg 1561 tcgtcaccca gcccgagcgt gagtcgacgg gtccggcggc gatctccgcc accgtcttca 1621 acaccggtga caccgcccag acgctggacg cgatcaaggt ggccggtgtc gaccagcccg 1681 ccgagatcaa ggctcccaag ggcggcaagc tgaccgtccc ggccggcggc tccgtcgtca 1741 tcggcggcaa gggcaacgcc gtggccaccg tggagagcgg ccacgaggcg gtgcgggacg 1801 gcaacgtgca gaaggtcacc ttcaccttca gcaagaccgg tgacgtggcg ctggacgcgt 1861 tcgtcgtccc ggccgagagc tacttctccg agtacggccc gagcgaggtg ccaagcgcgt 1921 ccgccgaggc gccctccggc aagccgtccg agtccgcctc gggcaagccg tcggcctccg 1981 cctccggcac cccgaccgac caggcctccg ccagcgcttc ggcgtccgcg tcggcctcgg 2041 agtcggccgg tcactgagac accttggata cgccggaagg gcgggacctc tccgtgaggt 2101 cccgcccttc cggcgtaccg gcgtgtccgc cccgcggtgt ctacggctcg aacttgtagc 2161 cgaggccgcg cacggtcacc aggtagcgcg gggcgcccgg gtccggctcg atcttggcgc 2221 gcagccgctt gacgtggacg tcgagggtct tggtgtcccc gacgtagtcg gcgccccaga 2281 cgcggtcgat gagctgcatg cgggtgagca cccggccggc gttgcgcagc agcatctcca 2341 gcaggtcgaa ctccttcagc ggcaggtcga ccttggagcc gccgacggtg accacgtgcc 2401 ggtcgacgtc catgcggacc gggccggcct ccagcgcggt cggggtcacc tcctccggct 2461 cgccgcggcg gcgcaggacg gcgcggatgc gggcgaccag ctcacgggag gagaagggct 2521 tggtgacgta gtcgtcggcc cctatctcca ggccgacgac cttgtcgatc tcgctgtcct 2581 tggcggtcac catgatcacg gggacgttgg agcggccgcg cagctgacgg cacacctccg 2641 tgccgggcag ccccggcagc atcaggtcga ggaggacgag gtcggcgccg ttgcgctcga 2701 actcgtcgag tccgtcgggt ccggtggccg cgacggccac ctcgaagccc tccttgcgga 2761 gcatgtacga cagggcgtcg gagaaggact cctcgtcctc gacgacgagc acacgggtca 2821 cggaaggacc tccggggcgg aaagcgtttc gtacgcggtc ggatcagggg gtgacgcagt 2881 ggatgaggca gaggtggtgc ggcgggtgcc cgcctcgtcg tcgagggcgg ggtgctgcag 2941 ggcgcggtcc cggtcgcggg ccgctcccgc ctccggcagg cgcagcgtga aggtggagcc 3001 ctgtccctcg gcgctccaca ccgtgacctc cccgccgtgc gaggcgacca cgtgcttgac 3061 gatggccagg ccgaggccgg tgccgccggt ggcccgggac cgggccgggt cgacccggta 3121 gaagcgctcg aagatgcgct ccttgtcctt gtcggagatg ccgatgccct ggtcggtcac 3181 ggcgatctcg atcatgtccc cgccgggcgc ggtcacccgg cgggcggcga tgccgacgcg 3241 ggtgcgggcc ggggagtagt tgacggcgtt ctcgacgagg ttgccgagcg cggcggcgag 3301 ctggccgcgg ttgccccaca cccgcaggtc ggccgtaccg cccgcggtca tggtgatgtt 3361 cttggtgccg gcctggtggc ggcagcggtc gatggcctcg ttgaccagtt cgtcgacgcc 3421 gacgggttcg gcgtcctcca gcgggtcgtc gttctgcacg cgggagaggt cgatcagctc 3481 ctgcacgagg ttggtcagcc gggtcgcctc gatctgcatg cggccggcga agcgctgcac 3541 ggcctccggg tcgtcggagg cgtccatgac ggcctcggac agcagggaga gcgcgccgac 3601 gggcgtcttc agctcgtggc tcacgttggc gacgaagtcg cgtcgtacgg cctcgatccg 3661 gcgggcctcg gtgaggtcct ccacgaggag cagcacgagc cgtgagccga gcggggcgac 3721 gcgcgcggag acggcgagcg cctccccgcg gccggtgccg cgccggggca ggtccagctc 3781 gacctggcgt atctcaccgt cgcgtcgcgt gtcccgggcc atctggagca tgggctcgac 3841 ggccagtttg ccgccgcgga ccagaccgag ggcgtacgcc gccgagctgg ccttgacgac 3901 gccgtccgcc tcgtcgagga cgacggcgga ggagcggagc acggacagga cggtgtcgac 3961 gccgggcggg agcaccgggt ctgtgtgcaa agaggtgcgg gtcgggcgct tcagctcccg 4021 ctcgctccag cggaacgcca gcatggcgat gacaccggtg agcaccccgg cgatcgctgc 4081 cgctgcggcg accgccgcgt tcacgtccat ggctccaggt taggcacggg atgcgggctg 4141 cccacagccg tccgggtgcg acctcgaaca ctcgtcgccc agagttcacc tgggagccag 4201 taccggttca tttggggtga cggaatccga cgcgtacggc gtcgaacgtg ggagcgtggg 4261 gttctgagcc ccgtcgacaa acctgagaag acgtacggga aaccgccgta ccggaacccc 4321 cggcgcacac gtgagagagg gaccctgatg cgggacgcgt accacgagga actggattcg 4381 atcggcgacg gtctggtgga gatggcccgg ctggtcggct cggcgatcgg gcgcgccacg 4441 acggcgatcc tcgacgccga cctgaagctg gccgagagcg tgatcgaggc cgaccagaag 4501 gtcgacgagc tgcagcacgg cctggaggcg cgggcgatag cgctgctggc ccggcagcag 4561 ccggtggcga cggatctgcg gatcgtcgtg acgtcgctgc ggatgagcgc cgacctggag 4621 cgctcgggcg acctcgccca gcatgtggcg aagctggcgc ggctgcggtt cccggagcgg 4681 gcggtgccgc aggacctgca cgcgacgatc ctggagatgg ggcagctcgc gcagcgcctg 4741 atggcgaagg ccgcggaggt gatcatcacc aaggacgtcg acctggcgct gcagctggag 4801 caggacgacg acgcgatgga cctgctgcac cgcacgctct tccagcacct gatcgacgag 4861 cggtggaagc acggcatcga gacggcggtg gacgtgacgc tgctgggccg ctactacgag 4921 cggtacgccg accacgcggt cgcggtggcc aagcgggtgg tgtacctggt gacgggtgag 4981 cacgcggacg agctgcagca ggacacgcag acggtgacgg gggtggaggg cgcctgagcc 5041 ccgctccggg tggtgttcgg gggcgcgtgc ctggggcggt gcgctgatgt gcgccgttga 5101 tgcgcccagc cgggcgggca tgcaatgggc acaggcacca gccgaggagg gaccatggcc 5161 gaatccccca gcacccccag caccccgccc gaccccacgc aggaacgccc gaccgagcag 5221 cccgccgaga tcaggaacct gatgctgatc ggcgcgtgcg ggtgcggttc ggggtgcggg 5281 tgcggttgcc agtcgggcaa tccgtgccag tgcggctgag ggtggtggcg tagccgccgg 5341 tacgacgacg agggcccggg tgcgttctgc gcgccggggc ccttcgtcgt cgtggccgcg 5401 cggtcgccgt ggagaccggt ggggcgcagg atgaggggag gaaaggacag ggcgggacgg 5461 cacggaagga ggtgcgggga tggctcggta catggacatc caccgtggca tgaagggcat 5521 cacggccgac cagctgaagc aggcccacga ggcggacctc gccatcgaga aggacgaggg 5581 cgtccacttc gagcgggcct gggccgaccc ggagaccggc acggtctact gcctctccga 5641 ggccccctcg gccgaggcgg tccagcgcat ccacgaacgc gcgggccaca aggcggacga 5701 ggtgcacgcg gtaccgctgc aggtctgacc acacgagacc caccggaacg gggacggcac 5761 gccggcgccg tccccgtcgc gcgcgcccgc gctgcggtcg cgtgggcgac acatactggt 5821 cacgcttggg tcgcggccgg gcgatcagcg gctttcggcc ttgaccggga aatgctctta 5881 ggtgaggctt acctaaatct tgctatgtac gtcctaggag ccccctgtgt ccgtcctgcc 5941 ctcggagaca tccgtgcccc cgtcggccgc ggccacccgc cgcctggggc tgtacgacac 6001 ctggtggacg gtcgcggccg gcgcactggc cgcctgcctc ggcatcgccg cctgcgcctg 6061 ggtctccctg cacctgcacg ccgacgccgc cctgcacagc gcggccctgt tcctccatct 6121 cgccgcgctg gtgctcggct tcggcgcggt gctcgtcgcc gactactacg cgctgctgtt 6181 cctgaccggc cggtgcagcc tgcgcgacgc cctcaccacg accggacgcc tgcacgcccc 6241 gatctgggcc ggcctcgtcg gcctggtggc cagcggcgcg ctgctccacc cggacctcgg 6301 ctccgtcctc acccgcgtga agctgggact ggtcctcgcc ctcaccctca acggcctgca 6361 ggccggcgtc ctgaaccggc ggatgcggga cgagacgggc accccgctca ccggccgcct 6421 cctcgcctgg ggagccggga ccgccctggt gtcccaggtc tgctggtggg gagccgtgct 6481 catcgggttc cgcaacagtc agcgctaggc ctgtcgcgga agtcccgtcg tccgccggag 6541 gacgggctcg gcggtgtccg ggtcaacggt cagggcacca ggaccaactt gcccgtcaca 6601 tggccctctt cgcccagggc gtgggcccgc gccgcctccg acagggggat gacctcctgc 6661 acgtgggccc gcagggcgcc cttgcgggcc aggtcggcga cggccgtcat gccggtgtgg 6721 tcgtgctcca ccagcatggc ggcgtaccgg acgccccggt cggcgcaggc ggccagctcc 6781 tcctccgtcg cgcccggcag cagggcgacc agcgtgccgc ccggccgcag tacctccacc 6841 gtgcggatcc gggtggcgtc cgtcatcggc accagcgcca cgtccacgtc ccgcaccacg 6901 tcacggaagt cggtggtgcg gtagtcgacg acctcgtcgg cgcccagcga gcggacgaag 6961 tcgtgcttgg ccgcgctcgc cgtaccggtg acccgggcgc ccagatgctt ggcgatctgc 7021 accgccaggt gaccgacccc gcccgccgcc gcgtggatca gcacatgctg cccgggccgc 7081 acgtcggcgg tgtcgaccag cgcctgatac gccgtcagcg cggccaacgg cagcgctccg 7141 gcctggacat ggtcgatctc gtccggcttg gccgcgaagg cgcgggccgg tccgacggcg 7201 tactcggcgt gcgagccgac cccgtgcggg tagggcagca tgccgaacac ctcgtcgccc 7261 ggccggaaca gggtgacgcc gaagccgacc tgctccaccg tgcccgacag gtcccagccg 7321 aggacccgcg gcggctgctc gaaccacacc cggcgggccc ggttcttcca gtcggtcggg 7381 ttgacgcccg cggcccgtac ccgcacgagg atctgaccgg gtccgggctg cggcaccggc 7441 aggtccacct cctgcaggac gtccaggcct ccgtaccgct gctggctgat cgcgcgcatg 7501 gtgctcctca gggaagaaga cggggtggtt ccgtcaccgt agggcgcggg cgggcggcgt 7561 aggtggtggc cgtgacacca ggatccgcac ccacttcctg gccctcttcg cggccagcac 7621 gatcgagaca tgatccagtc actgacagag gcgctgcggt cgcacgagga ccgagaggcg 7681 atcatcttcc atgggcagag cacgagttat cggacgctgc tgaccggcgt cgagaagtgg 7741 cgggcccggc tgaacgagta cggcatccgc ccggggcagg tcgtcgcgct ggagtcggcg 7801 tactcgccgc aggcctgcgc cgcgctcgtc gccctcatcg agaccggcgc gatcatcgtc 7861 ccgctggtca cgctgccgga cgccaagcgg gccgagttcc atgagatcgc cgaggttgag 7921 gcggtcatca cgctcgacgg cagcgaggcc ggctggacca tcaccaccac cggccgcacc 7981 gccggccacg agctgttcac cgcgctgcgc cgcgagcggc accccggcct ggtgctgttc 8041 agctccggca ccaccggccg cagcaaggcc tccgtgctgg acttcaccaa ggtcctcgcc 8101 cgctaccggg gcggccggcc cgcgcggacg ctgtccttcc tcaacctcga ccacatcggc 8161 ggcgtcaaca ccctgctgca cacgctggtc cacggcggcg cggtcgtcac cgtcgccgaa 8221 cgcaccccgg acagcgtctt cgccgcgatc gaggcacacc gggtggaggt gctgccgacc 8281 acgccgacct tcctcaccat ggccgtggtc tccggcgccg tccgccgcca cgacgcgtcc 8341 tcgctgcgcc tggtgacgta cggcaccgag ccgatgcccg agcagacgct gctcgccgtg 8401 cacgaggcgc tgcccgaggt gcggctgaag cagacgtacg gcctgtcgga gctgggcatc 8461 ctgccgaccc ggtccaagga cgactcctcg ctgtgggtca ggctcggcgg cagcggcttc 8521 gactacaaga tcgtcgacgg ggtgctgtgg gtccgctccg agatggccat gctcggctac 8581 ctcaacgcgc ccgccccctt cgacgaggac ggctacttca acacccagga catggtggtg 8641 gtggagggcg agtacctgcg gatcctcggc cgccgctccg agatcatcaa cgtgggcggc 8701 gagaaggtct acccggccga ggtcgagaac gtcgtcctgg aggccggcaa catcgccgac 8761 gtcaccgtct ccggccggcc cagcccggtc accggcatgg tcgtgcaggc cacggtgaag 8821 ctggtgcgcc cggaggacga ggacgccgtc gcggcccgcg tgcaggacca ctgcgcggcc 8881 cgcctggagc cgtacaaggt gcccctgatc gtgcaggtct cgcaggccga ccagcactcc 8941 gaccgcttca agaagctcag gagcgcggcg tgagcgacac gacggccggt gtcgccctcg 9001 tcagcggcgg cagccggggc ctcgggcaga ccctggtgac gcggctgctg gcggagggct 9061 ggcaggtcgc caccttcagc cgcaccgccg gcgacttcgt cgagcagacc ctgaaggccg 9121 agcccgaccg gttcttctgg accgaggccg acctgctgcg gcccgagacc gtgcgggcgg 9181 cgggcaaggc cgcgatcgac cggttcggcc ggatcgacct gctcgtcaac aacgcgggcg 9241 tgctggagca gggcctgttc gtgacgatgc cgccgcggcg ggcggaggac ctcgtcaccg 9301 ccaacctgac ctcgccggtg gtgctggcgc aggtggccgc ccggtccatg gtggcctccg 9361 gcggcggcca gatcatcaac atctcctcgg tcaacgccgt gcgcggctac cggggtgtgg 9421 ccgcctacag cgcggccaag gcgggcctgg acgggctgac ccacagcctc gcccgcgaac 9481 tgggcccggc cggcatccgc gtcaacacgg tcgtgcccgg cttcttcgac tcggacatga 9541 ccgagggcgt cggcccggag taccgcgagc gcatccagcg ccgcaccccc ctcggccggc 9601 tgggcgaccg ggccgaggtc gccgacgccg tgctgttcct ggcttctccg cgggccggtt 9661 tcgtcaccgg tcagcggctc gtcatcgacg gaggaatcac atgctgagca acacgctgac 9721 cgacacgcgg accaccgacg tgcaggccac ggtcgtccag gagatcgtcg cgatcctcga 9781 cgaggacacc gtcgacgagc tgggcgagct gaccgccgac accgagctga gcgcgctcgg 9841 cctcaactcc ctcgccttcg cccggctcat catcaagctg gagcgcgccc tcggcgtcga 9901 cccgttcagc cagggcggcg acttcgtcgc gctgcgcacc gtgggcgccc tggccggggc 9961 gtacgagcag gcgctgagcg cccgtacgga ggcctgagcc atgtccacgg cgacgacgac 10021 cctgctgcac ctgccctcgg tcgacgacta cctcggcccg tccgccaccc gcttcttctc 10081 cgccggctac cggcgcgccg aacacaccgt cgacgactta cggatatcca ccggcaccgc 10141 caccggcgac cgtccgggcg tgagcgcccg cgtctcgctc gcctacccgc gcgactggtc 10201 gaagaagaag gcctccaccg acctgttccc gcacgtcagc accgtcgaca tgctggtgat 10261 cggcatccag ctgtgcgagg cgtacctcgc ccacgtgcac cggctgggcg ccgccgaccg 10321 tcgccgggcc cgcgtccgca agatcacgct gaaggcgggg accaccccgc aggaggagct 10381 gaccggcctc accgcgggcg ccgaactgcg ccgcacccac caggacccgg cggccgccgg 10441 cgggcacgtg tcgacgttca ccgcgcacgt cggggtgatg acggcccggt acgagatcga 10501 gcacgccgtc gcggacgagc cgcgcgggga ggggacgtac gcctccctcg acgacgtcct 10561 cggcccggcc gccgcccgct actacggcga cggcttcaag ctccgcagcc acacggtcac 10621 cgacgtacgc gccgacgtgg ccgaactgac cgccaccgcg accgtcgccg cgcacgacct 10681 gccgggatac gccgacgccg tcaccgccgg tctcgacggc gagcgcctgg ccggcgaact 10741 gaccccggtc gactgcttcg tgacgaacct gcagctcatc caggtcctga tgtacgagct 10801 ggacggcatc cgccgccagg acagcaacac cctgtggatg cagcagaccg tgctgaccgc 10861 caccggcccc gcccacccgg cggaccggcc ggccaccgcc gaggccgccc tcaccggcag 10921 ctggctggtc ccgctgcgcg gcggcctgtg gcgggacgtc gcgatcagcg cccgcctggg 10981 cggctacgag atgcagtgct ccttcgccca cgaactcccg ccgttcgccg ccgccgcggc 11041 cgccgccgac ccgaccccga gggcctgaca tgaagatctc cgtatccggt acctactccg 11101 cgggcaagac ctccacggtc atggccctct cccactacct gggcctgccc cgcaccctcg 11161 ccaagaccat ccgcgagatc ctgccggagg ccgtccccgg caaggcgctc gccgaggtca 11221 cccccgccga gttcctgcac ctgatgctgc gccggcactg cggccgcgcg gtcgccgagg 11281 cccggctcgg cgactcgttc ctctccgacg gctcctccct gcaggagtgg ctgtacggcg 11341 ccgcccgcgt ccgccacggc atgaacccca acgccaccgc cgccaacgac ggcggcctcg 11401 cccccgaggt cacccccgag atgcggttct tcggcgaggt cgtcgacgag tacggcaagg 11461 cgttccgccg gcacgtgcag gagacgtacg acgtcttcat ccacctggag cacgagctgg 11521 agatcacctc ggacggccac cgcccgatga acaagggctt ccgcgacacc atcgaccgca 11581 tgctcctgga caccgtgcgg gagctgggca tcccgctgca ccggatcagc ggcacgatgc 11641 ccgagcgcat ggagaagatc accgcggtgc tcggcctgac ccccgtgatg agcatcgagg 11701 aggccctcgc cctcggcaag cgcgagtacg acgcccagga cttccgcctg gagacggaac 11761 gggcggcagc ggcatgaacg ctctcaaccg cagacgcctc ctcgtctcca ccgcggcact 11821 cacggccggc ctcggcctgc ccctggaggc ccacgccgcg tacggcgcgg acgcggcgac 11881 ctcgtcggcg tacagcgagc gctcccgcac cggccgcaag ctgcgccagc gggccgccga 11941 gcgggactac ccggccacgc tgcccgacca cccggtcaac ggcgaggagt ccctcccctc 12001 caagatcgcc agctactcga agggcctgcc gcacaacgac ctcggcgagg tcgacgtcac 12061 cgcgtacgcc cggctgatcc acgccctcac gaccggcaac cccgccgact tcgaggcgat 12121 cccctcggcg ggcgagcgca agcagctcgg cccgcagggc gggctcgcct acgacctcgc 12181 cggacccgac ccgttcaagc tggtcgtgcc gcccgccccg cgcatggaca gcgcgcaggg 12241 cgccgccgag atggccgagc tgtactggct ggcgatgctg cgggacgtga agttcaccga 12301 cttcgaggac tcaccgctcg ccgccgctgc ggccgccgac ctgtccacgt actccgacat 12361 ccacgcgccc aagcagggcg gcgggatcac cccgcagacc ctgttccgcg ggaacacccc 12421 ggccgatctg accggcccgt tcgtctcgca gttcctgctg cggaccgtcc agtacggcac 12481 cctgcgcgtc ccgcagctgc acgacaccgt cgctcccggc gtcgaccacg gcaccgactt 12541 cgcggagtgg ctcgccctcc agcgcggcgc ggcccgctcc acccagcggg acttcgccgg 12601 cacccgctac ctccagacgc cccgcgacct ggcccactac acccacttcg acgtcctgta 12661 ccaggcctac ctgaacgccg cgctgatcct gctggcgctg ccgcaggccg ccgtacagga 12721 ccggggcaac ccctacctga cgtcgaagaa ccagatgggc ttcccgacgt acggcacccc 12781 gcacctggtg tcactgctgg ccgaggcggc gatccgggcc atcaagcaca ccgagtacca 12841 gcagttctac gtccaccggc gggcccgccc ggaggccttc ggcggccgta tcgaggtgca 12901 cctgcggcgc agccccggcc gctacaccgg cctgctccac gaggagatcc tgcgctcgga 12961 ggtgctggag cggacgcgcg cggcgaccgg ctcgtacctg ctgccgctgt ccttcccgga 13021 gggctccccg atgagcccgt cgtaccagag cgggcacgcg acggtcgcgg gcgcgtgcac 13081 gaccgtcctc aaggcctggt tcgacgagtc gtacgtcctc accgacccgg tcgtgccgag 13141 cgccgacggc aagtccctgg tgccgtacac gggcgccggc caggactccc tgaccatcgg 13201 cggcgagctg aacaagctcg cggccaacat cggcgcgggc cgggccgcct cgggcgtcca 13261 ctaccgcacc gacaacacgg cggcgtacac gctcggcgag acgatcgccc tggagctgct 13321 gcgcgagcag aagccgctgt tcaacgaggg tggcggcttc tccgtcacct gcttcgacgg 13381 cacggccgtc accatctgat ccccgctcac gctgttcacg ccgaaggaag cagagaaaag 13441 acgatgcgga agacgcaact gggaacgcag ggcctcgagg tctcggcggt cggcctcggc 13501 tgcatgggca tgacgttcgg gtacggctcg gtcgaggagt cgcggtcgat cgccacgatc 13561 gagcgggcgc tggagctggg ggtcgacttc ctcgactcct ccgaccacta cggccccgag 13621 accaacgaga cgctgatcgg gcgggccatc gccggccgcc gcgacgaggt gatcgtcgcg 13681 accaagttcg gcagctactc caccgagacg ccgccgcgga tccccgacgg ccgcccggag 13741 accgtgcgct gggccgtcga gggctcgctg aagcggctcg gcaccgacta catcgacctt 13801 tactaccagc accgggtcga cccgcgcgtg ccggtcgagg agaccgtcgg cgtgatggcc 13861 gagctggtcg ccgagggcaa ggtgcgctac ctcggcctgt gcgaggcgtc ggcgcagacg 13921 atccggcggg cgcacgccgt ccacccgatc acggccgtgc agagcgagta ctcgctgtgg 13981 acgcgggacg ccgaggagga ggtgctgccg acgctgaagg agctgggcat cggcttcgtg 14041 gcgtacagcc cgctcggccg cggcttcctc accggcacga tctcctcgct ggacagcctc 14101 gcggagaacg acttccggcg gatcgcgccg cgcttccagg gcgacaacct cgacgccaac 14161 cggggcctgc tgcgccggct gcaggagatc gccggggagc ggggcgtgac gcccgcgcag 14221 gtcgcgctgg cgtgggtgct gcgcccggcc gagggcatcg tgccgatccc cggcacgacg 14281 cgcccgcagc gggtggacga gaacagcgcg gcgctggaca tcgcgctgac cgacacggag 14341 atcgcggagc tgtcggcggt gttcgcgccc ggttcggcgg tgggcgaccg ctacccggcg 14401 ccgatgatgg cgacgctgaa cggctgagcg gtggtgtgag ggacggcgag gggtgcccct 14461 ggtacgacgg gggcaccctt ctctgtgcct acaggtgggc ggcgttgagg atgccgcggg 14521 tgtccacgcc ggtctcctgc tcgggccgcg ggttgtagag gacgatcagc aggtcgggga 14581 actgcgggat gcgcatcctg gtgacgtcga agtgcagcac ccccagctcg ggatggtcga 14641 cgaccttgac gttgacccct tcggcccgca cgtcgtgccg ggcccacagt tcggcgaact 14701 ccgggctctt cttggtcagt tcaccgacga cgatctcgaa cccgaggtca ccgggccggg 14761 tggtcatccc gtaccggtac tgggcgacga tccagggcgc gagttcggcc cagttgagga 14821 cgcgggagcg caccaggggg ctggtgaaga aggtgacgag cgagttccgg tcggttttcc 14881 ggtacccgag caggtcgtac gtcgcctggt tggcggtgac caggttccag tacgggtcga 14941 cgacgaacgc cgggtacggc aggttgttct cggtaagacg cgccagcatg acatccactt 15001 cgagcggctc agaactgaga ggcagcggcg gattcagacc ggccagcaca tacaggtagg 15061 tgcgctcggc ctggtcgagc cggagcacct tggtgatggc gtcgagcacc tgcggggaca 15121 cggagatgtt ccggccctgt tccagccact ggtaccagga ggcgctgact ccggccagga 15181 aggcgacttc ctcgcgccgc agcccgggcg tcctccggcg tccgtagtgc gggatcccga 15241 cgtcgccggg cgtcagccgg ccgcgccggt tgaccaggaa gtcccgcagt tccttgcggc 15301 gacgggcctc ggaggacgag gacctgccgc tgccggtccc gaccgccccg gcggccggct 15361 tcgcagccgc cgccccctct tccggtacct ctcccgctcc gcgcggcggg gccttggcct 15421 ccgccgactt tccggtgatc gcgtacacga tctgcacccc ccattccggc cgcgcttccc 15481 cagcggcggc ctgtgttcta cgtgatccgg agcgcgtgca cagcgaacgg gaacgcccct 15541 cgcagcgaag cccccttgct tgcgtgcgac cgagccgaca ctgcacagcg cgctgccgaa 15601 ggcacagacg aagcttcccc tcgggcatgt acaactcagg ccgaaaagac caaggtttga 15661 ccgtgatgtt gcccacgttt cggacacggg gggcgcgggc gtggccggag ccggagttct 15721 tgcgggggtg agggccacgg tgtcaggtgt caggtgtcag gtgcagtcca cgggatcagt 15781 tactcaggcg tggcggtgac acgccacaag ggaggttcat actgctccgg gcggctgtcg 15841 atgaccaggc gtcgcagcgc ctcgcgctgg gaaccgggga gattcaaggc ctccgtaagc 15901 cgccgaaatg tcgtatgggt gacgccacgg cgccgcgctt ccgcctcgaa ccggtcgagc 15961 tgcgccgaca ccacgtcggc gtcgatctcc acgggcggct gctcgctcaa ccgggcggcc 16021 ttctcccgtt cgtggtcgat ctcggagatc ccgcagattt cgcgggcgta cgcctcgacc 16081 tcgtccaagg cggcggtggt catgatggcg cgggcgaggc ggttccggtt caccgcttcg 16141 tccaggtcga cagcgtgaac cctcggtccc tcgtccgtga gcgccacggc cggcccggca 16201 tcgcgcacct cacagctgcc ccgaacccct cgggcggtgg cggcgagcat ggcggccacc 16261 tcggagggat gccactccag aacgctgctc accggctcga cgtccgtcgc cgtgaaggtg 16321 tggacgacag gcccgaggag tggccgcagc gcatccggcg gaagctcgcc atccagcccc 16381 ggcccggcca ccagcaaccg cacggacgca ttgacctggc acgcggcggc cagggtaagg 16441 gcatcggcga gcggactctt cagcgtcggc tcgccgccct gcgcgagaat gtccccaccg 16501 acgtcgagga gatcgatcga ctcgggctcc aattggcgca cgacttcctc cagctgccgc 16561 gtaacaccct caacgccccg ctgcggatcg agcagcgcga aggtgtgcgg aagctccgcc 16621 gccagacgcg gcagcgtgga ccgggtgggc gcaacgggcc gagcactcgc gggcacggtc 16681 cgcacggcgg aggtcagggg ggcaagcccc tcaaagtcgc tcgtgctacg cggcccgggc 16741 acaggatcga cgaccagccg gtcccaggca taggtgagga tcacggccgg ttcctcgccg 16801 ccgtacaggg cggcgtgcag catggcggcg gcaacggcat cgcctccacc gccggccgcg 16861 acgatcagcc tcgtcatgac gccagcgtag gaggcaaaga gatacattta cgcgccacac 16921 acgctgcgct ccccgctttc ccttcgcatt gagcgtgtgg cggtcggcca cgcgggacgc 16981 ctggcccgag tcctcaacgc cctgtgacca ccacgagcaa ctggcgcaga cacgccggcg 17041 caaggagccg ggagacgatc cccggtgagc tgttcactcc gaatgtgccg ggcggcctgc 17101 ggcgagccga tcaccggccc ggacgacgtc atctacacgc tgacaggtcc cctggcctgc 17161 gcagcagggg atcctccgca aagctcccgc cacgggcaag cggggccgtt tcgtcgccgt 17221 ctcgacttgg gccggatatc cggcagaggc tgcgggtacc cgccccacag catggcccat 17281 ggccgagtcc ggtacgcggt gacagcaacg gagaaccaga tgaaggcccg ccaaacagca 17341 gccccgccga cgccgacgct ggtcccagcg gaggagcagc ccggcgaact cctttccggc 17401 cgctaccgtt tgggcgccag aatcggctcg ggaggcatgg ccgacgtgta cgagggcgtc 17461 gacacgcgcc ttcggcggtc cgtggccgtc aaggtgttcc ggcccggccc ggacccgcag 17521 acggaggacc gtctcaccgc ggaggccgtc cttctggccc gcctgcagca cccaggactg 17581 gtcaccgtct acgacgccgg ccgccacgac gaccgcacct acctggtcat gcaactgatc 17641 gaaggcccca cgctgcgcgg cattctggcg tccggagcgc tgcccgagcg gcgtgtggtg 17701 gaggtgggcg ccgccctcgc ccgggtgctg gcgtatgtcc accagtccgg cgtcgtgcac 17761 cgggacatca aaccgtcgaa tatcctcctc gacacggccg gcgctcctca cctcgccgac 17821 ttcggcatcg cgcgcctggc caacgccacc cgccacacgg caccggacgt actgataggg 17881 accgccgcct acctggcacc agagcaggtc aagggccggc agatcgggcc ggccgccgac 17941 gtctacgcgc tcggcctggt cctgctggag tgcctgaaag gggaactgga gtaccagggc 18001 acccccttgg aggcgaccgt cgcccgcctg caccgcccac ccgacgtccc cgcctggctc 18061 cccccggaac tcgcggccct gctgcgggcc atgaccgccc aggaccccga ggcccgcccg 18121 gacgccgagc agtgcgcaca agccctcgcc tcccggcaca ccgggcctgc cccctacccc 18181 ctgccgctcc cggcgccctc cgggtcggcc cttccgacgc cgccggccac tccccccggg 18241 acgaaggagc acatacgctc ccaggatgcg gtcgtcaccc ggcgcggcct ccccggcggc 18301 acgcgccacg gccgtcgtct ggcggcgggc acggccctgg ccctctccgt ggccctgggc 18361 gcgactcttg ccgccacatc gagcaccagc gaaagcgccg accggaacgc agggacaccc 18421 gccacaaccc ccgcacaccc gccctccggt accgcgacag cgaagagcgg acccggcgcc 18481 cctcccccca cccggtctca cggcactcag cccccttccg ggacatccgg tgcgtccgat 18541 cccgcggccg cgacgaccgg ctcccacgcc cagcccgctt ccaggacact cggcgcccct 18601 gatccggcgg ccgccccggg ttcgagccgc ggcgcctccg caccgcacac gagtcaccgg 18661 ccgcccggat cggcgtcacc atccacgccg accgcgaccg gcgccaccgg cccgacccag 18721 acgacacctg cggcatcgcc gaccaccggc acggcgcccg cgtcaccgcg gccctcgaag 18781 ggcaaggcca ccggcgcacc ccccaagccg agcccgacgc ggtagaggcc gacccgcccg 18841 gggcacaccc gcgtcaggag cccgccccgg agcgacggcc tacagacagc gaaaagcccc 18901 ctccgcggag aacccgcagg cagggggcca atgacatggg cgtctacttc ttcttaccct 18961 gggtcttgcc ggggatcttg atgagctgcg tttctgctgg ttagcgccgt attagaacgc 19021 ggctgcggag tcactctttg tcgttgttgg ctgctgtcga gcagcctcgg acggccccag 19081 gacggcccag agccgggctc agtgttcaga cacagagtgc ccaggccacg caaagcatca 19141 cgtcgtacag ggataggcct cgtatctatg caacaaggtc gagggagcca tacgcgacgt 19201 cggcgaagct atcccggact gcctgaaaac gctccagcag tgggtctcgg acgaagccac 19261 cgatcatctc gtcccagaac gcaacacagt tggccacttc cattacgtgc ttgacctgtt 19321 ccgcatccaa ggcgtgactc tcctgcaagg tgaactccaa gaggtcgagc ttctcccacc 19381 gctcctcatc ctccagacgc ccccactcgc ataagagccc ccaggccacg tgcgcggagt 19441 tgtggtgtgg gtcctggcac cactcggcgt tgcgagggca ccaagcgtcc tccagggcac 19501 tgatcgccga tctcagcaca gctctgcgaa gtgccaactt ctccaattgg gcgcactgct 19561 cggccaccct ctccgcttga ctgagaactg gcggcggccc cagaacggca acgccagccc 19621 gggcctgcac cacggcggtc gccttctgat cgagcagttc tcgccgtgaa gcgcgaggca 19681 tgtctggtag cgcggtgacg atccggacga agacgtctac cgcactcagg aagtcggcat 19741 aggccgagcg acgtgcactc tccaaggact cctcccgtaa cgcacgctcc tggagttggg 19801 cagccgccac tgtggcctga gattgatcaa ggcctgccgc caccgtcgca ttagcggcct 19861 tgtctgcgct acgtctggtc cagtgggcag cgagcagagt ggcaggcacc gtgatgaggg 19921 tggttagagc gctcgttgcc gctacagctt gttctagttg cacgagacgc atagtggtgt 19981 cagagcctgt cagccgcggt aaaaaggtga atcagccgag gatgaccgtc gcgccatgct 20041 aggtccctca tggggagaag cgccccatct tgcctgaccg ccgcccctgg ggggaaaccc 20101 gtatggttcc ggccctctga cctggccttt cgccgcagac ggccgcgaca cacctgtcac 20161 tgccggtcgc cgttggtcga cctcgggcac cctcgcacgg cccagggacg gcccagggct 20221 gagccgagcc gggagcgggg atcaaaagct gctgcgccgc accgacaccg gtcactcaag 20281 tggcaaggga gcgactggga gctgttcctt gtggagccac ctgaaggtcc ggtccggttc 20341 gaggtgggcc tctccccagt gaatgacgtg gatgccgttc tccgcgtcgg ccgtgaagaa 20401 cacgcagacg agcctcgtgg aggcccccag ctcctcgaat gcctcgtgca ggcccaggta 20461 ctcctccgtc gccaggccag catcgacctc gaacagcccg tctggagcct gcggcccgtg 20521 ggcccggaac agccgctgcc gggtggggga cgcgttggca ggcaaccgcg cacgatccag 20581 gggccgcggc ttgtctgcgt acctgaaggg gaagagcgcg tgctcgttga tcacggcgta 20641 ctcgtacccc cggacatccc gcacggactc ccccagctcc cgcgccgcgt ccgccaggcc 20701 ctcacgcaca gccccggcaa gggcgacacc gtaggggctc cgcttcttca gccctgccgc 20761 tatgtgcgcc gcatgagcct tggcgtgcgc cctggccagt tgtagcggaa cagcagcggc 20821 gagcgcgccg gcatgccgcc cgaaccgctc aaccgcccag tccgacggtc ctaccggctc 20881 acgaccccgc acagacatga agcgcccccc ctcgcccgat cacccgcctt tcaactgtgt 20941 gacacgtaca cgaacggcac acaagggagc gatctagcca cggcatcgcg cagacaacgc 21001 tgctgggaga gcgcgcaccc tatcttcgcc tgtatgttcg cgaacaggta gtcatcacaa 21061 cgggcgca //