LOCUS       NZ_BNBR01000005        41161 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence05, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000005
VERSION     NZ_BNBR01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 764915)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 497897
            Orig. end                         :: 539058
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..41161
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="arylpolyene"
                     /region_number="3"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     cand_cluster    1..41161
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..41161
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="False"
                     /core_location="[20000:21161](-)"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..21161)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     misc_feature    complement(841..856)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.44"
                     /tool="antismash"
     misc_feature    complement(849..865)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.61"
                     /tool="antismash"
     gene            1022..2530
                     /locus_tag="IE308_RS25345"
                     /old_locus_tag="GCM10018783_51440"
     CDS             1022..2530
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845918.1"
                     /locus_tag="IE308_RS25345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51440"
                     /product="MFS transporter"
                     /protein_id="WP_190219674.1"
                     /transl_table=11
                     /translation="MAGRGEGAGGFPAPASVRLASPTGRWLVLTTVLGSSMALLDSTVV
                     NVALPRIGRDLGADLAALQWTVNAYLVTLAGLILLGGALGDRYGRRKVFVVGVVWFAAA
                     SLLCGLAPNAGVLIAARALQGVGGALLTPGSLALIQASFHPDDRGRAVGLWSGFGGIGA
                     AVGPFLGGWLVDGPGWRWVFLLNVPLAAVCVPVALRHVPESSDGRADHGRFDALGAGLG
                     ALALALLTYALIEAREGSLVVAVTGVAGVAAAVAFVVVERRRPDPMMPLDVFRSRQFTA
                     VNLVTLCVYAAFGGFFFLAALQLQVVAGWSALGAGTALLPTTVLMLLFSARSGALADRI
                     GPRIPLTVGPLLCAAAMLLMLRVGADADYLTDVLPALLVMGTGMVTLVAPLTATVLASV
                     DSARAGLASGINNAAARAAGLVAVAALPLLAGMGPEAYRSATEFDRAFDKAMVWCAGVL
                     VLGAVVAVATVRRPVPGCARPECRRHGSVLAPPLEGRKPSESNR"
     gene            2688..3101
                     /locus_tag="IE308_RS25350"
                     /old_locus_tag="GCM10018783_51460"
     CDS             2688..3101
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009309423.1"
                     /locus_tag="IE308_RS25350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51460"
                     /product="DUF3151 domain-containing protein"
                     /protein_id="WP_110629412.1"
                     /transl_table=11
                     /translation="MTIHENLLGGPPPTRLPDDPEPRELLAAGTPAADVAAKYPTSSLA
                     WARLADEAFERGSVVESYAYARTGYHRGLDALRRNGWKGHGPIPWEHEPNRGFLRALHG
                     LARAAQAIGEQEEYERCAQFLKDSSETAAQTLG"
     gene            3261..4100
                     /locus_tag="IE308_RS25355"
                     /old_locus_tag="GCM10018783_51470"
     CDS             3261..4100
                     /GO_function="GO:0004833 - tryptophan 2,3-dioxygenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070378.1"
                     /locus_tag="IE308_RS25355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51470"
                     /product="tryptophan 2,3-dioxygenase family protein"
                     /protein_id="WP_190219675.1"
                     /transl_table=11
                     /translation="MSQEAQDIQEPETPHLDFEGTTPYEDYVKADVLTHLQHTLSDDPG
                     EMVFLVTTQVMELWFTVIVHEWETAARALRSDDVPTAIAALKRSVRELEALNASWKPLG
                     QLTPQQFNSYRSALGEGSGFQSAMYRRMEFLLGDKSASMLVPHRGAPRVHAELEKALHE
                     PSLYDEVLRLLARRGHAIPDELLTRDVSRRYEPSEAVEAAWTAVYAGDPGDDVARLGEA
                     LTNVAELVWRWRNDHLVATRRAMGAKPGTGGSAGVAWLEKRAQKNVFPELWTARSHV"
     gene            4093..5319
                     /gene="kynU"
                     /locus_tag="IE308_RS25360"
                     /old_locus_tag="GCM10018783_51480"
     CDS             4093..5319
                     /EC_number="3.7.1.3"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0030429 - kynureninase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006569 - tryptophan catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (33-319). E-value: 7.9e-22.
                     Score: 69.6. Matches aSDomain:
                     nrpspksdomains_IE308_RS25360_Aminotran_5.1"
                     /codon_start=1
                     /gene="kynU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975293.1"
                     /locus_tag="IE308_RS25360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51480"
                     /product="kynureninase"
                     /protein_id="WP_190219676.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-17, bitscore:
                     58.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPTSELALRAEKSDAADELAGLRERFVLDDTVYLDGNSLGALP
                     AHVPDRVADVVRRQWGELRIRSWEESGWWTAPERIGDRIAPLVGAAPGQIVVGDSTSVN
                     VFKALVAAVRMAGEGRDEIVVDASTFPTDGYIAESAARLTGCALRPVLPAEVPGVLGER
                     TAAVLLNHVDYRTGRLHDLPSLTAAVHAAGALAVWDLCHSAGALPVGLDEHGVDLAVGC
                     TYKYLNGGPGAPAYLYVRRELQPRFDSPLPGWNSHAEPFGMRPEYAPAEGAPRGRVGTP
                     DILSMLALEAALDVWDGVSVEAVRAKSLALTDFFLECVGRYVPEGRVECVTPLAHAERG
                     SQVALRCPDAGDVMRRLIERGVVGDYRAPDVLRFGFTPLYVGFADVERAARVLAETLAE
                     TVEGTSPGF"
     aSDomain        4192..5049
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS25360_Aminotran_5.1"
                     /evalue="7.90E-22"
                     /label="IE308_RS25360_Aminotran_5.1"
                     /locus_tag="IE308_RS25360"
                     /protein_end="319"
                     /protein_start="33"
                     /score="69.6"
                     /tool="antismash"
                     /translation="VYLDGNSLGALPAHVPDRVADVVRRQWGELRIRSWEESGWWTAPE
                     RIGDRIAPLVGAAPGQIVVGDSTSVNVFKALVAAVRMAGEGRDEIVVDASTFPTDGYIA
                     ESAARLTGCALRPVLPAEVPGVLGERTAAVLLNHVDYRTGRLHDLPSLTAAVHAAGALA
                     VWDLCHSAGALPVGLDEHGVDLAVGCTYKYLNGGPGAPAYLYVRRELQPRFDSPLPGWN
                     SHAEPFGMRPEYAPAEGAPRGRVGTPDILSMLALEAALDVWDGVSVEAVRAKSLALTDF
                     FLECV"
     misc_feature    5418..5431
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(5419..5432)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.0"
                     /tool="antismash"
     gene            5549..6418
                     /locus_tag="IE308_RS25365"
                     /old_locus_tag="GCM10018783_51490"
     CDS             5549..6418
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032061.1"
                     /locus_tag="IE308_RS25365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51490"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_110629415.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-08, bitscore:
                     30.5, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.3e-10, bitscore:
                     35.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDDVAAARAAAEEESAFSHPPVAPDTSAAYGDHPDQVIDFYAPR
                     AERGPGGPAPLVVVLHGGAWRAPYDRRHVSPFAAFLAGRGFGVALVEYRRGTEGDATLA
                     GRWPDTFDDVAAALDALPALARQALPQTDPRRTVVTGHSAGGHLALWAAARHVLPAGAP
                     WRLDGPPQLRGVVALAPIADFTVAEKLDVCGNAALQLLGGNELFAERQPYADPALLLPT
                     GIATTLVQGRADLDVPQAVAEAYADAAAKAGEVVGLTLLEDVGHFPLIDPVADACAVVA
                     EEIAQLAW"
     gene            6705..7646
                     /locus_tag="IE308_RS25370"
                     /old_locus_tag="GCM10018783_51500"
     CDS             6705..7646
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029137.1"
                     /locus_tag="IE308_RS25370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51500"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_308440126.1"
                     /transl_table=11
                     /translation="MRALPAAVVVTAIVLPLSAAARPVVPAPPPARLAPATAATLAGTY
                     AAHRGNAEKASRMAAAHGDDRRAAADRALAAPGRQLLAFDGRGSGRAVEVLGDLARADR
                     VAVLVPGSDTSLDTYGRFRATATALYDRLVHEAPPGTGVAVVAWLGYETPGTVGTAVLT
                     PDRADEAAPELRELIRQLPLITGPGSHVALLCHSYGSVVCARAASGPAVDDIVLIGSPG
                     TGAKDVTALRTTARVWAARGADDWIADVPHARAELLGVTVGFGTDPVSPQFGARVFAAG
                     DGGHGDYFRPGSVSLANLARIVLGEQAEVSRA"
     gene            7660..8913
                     /locus_tag="IE308_RS25375"
                     /old_locus_tag="GCM10018783_51510"
     CDS             7660..8913
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569000.1"
                     /locus_tag="IE308_RS25375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51510"
                     /product="acyltransferase"
                     /protein_id="WP_110636821.1"
                     /transl_table=11
                     /translation="MAARIDSATPADRDRAVDALRACAILGVVLGHWLVTALVSEGGTL
                     RTDSPLRALPWLAPVSWVFQTLAVFFLVGGHTATAGLASARARGVPYRRWLAARLARLW
                     RPAAAMLALWTVVAALLLATGAEFTTVRTLVKLALSPLWFLLVFAGLTAATPLLTRLSP
                     LWPLAVVLHVDLVRFGLGGPSWLGWVNVAAGWLVPYTLGAAWTRGELEGRRAGWALLAG
                     GAAATAALVAGAGYPASMVGVPGAEVSNLNPPTLAAVAFGLAQCGGALLLRGPLRRAMR
                     RRPVAWAGVAVANLSAMTVFLWHQTALMAATAAALPAGPLPGLHTRPDDLRWVAARLVW
                     LPLFALGLVVCRSAFHGFESRRGRTERRGSTGSDSRVVRARRPAGAAAGGRPEPAGDGP
                     EPVGKGPATAGEEVGRRA"
     misc_feature    7670..7684
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.71"
                     /tool="antismash"
     gene            8924..10339
                     /locus_tag="IE308_RS25380"
                     /old_locus_tag="GCM10018783_51520"
     CDS             8924..10339
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009309342.1"
                     /locus_tag="IE308_RS25380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51520"
                     /product="sensor histidine kinase"
                     /protein_id="WP_190219678.1"
                     /transl_table=11
                     /translation="MNGVGERLAREARVLWGELWAAGRAPLPPSVWLRWLPHGLVCLVA
                     FGVVIANGDQVGQGYRQGTEYALLCSLALGAGVVLALWWPVQGWWLSTAVNVVTAVGAR
                     SQLISGQAEPDSPWPWTPPGIVAEAMVLLLLALRMPTRVSVKILGLTALVTAVVQGWLG
                     GSNYAPTGTFAVALFAGVVLLGTALRGRREARHQLVEQAGITAEERARRALLEERSRIA
                     RELHDVVAHHMSVISIQAQVAPHLVENPSQELKENLAGIRNNALEALTELRRVLGVLRS
                     EHPEDASGVAAPGTGPAPDAPQPTLDRLDALLDNARSAGLTIATGIQGERRPYPQAVEL
                     SAYRIVQEALSNAIRHAPGSAVKVEIAHLPDGLFLGVTNSRPTRPAAPSPGVGHGLLGM
                     RERAAMLGGHVTAVPSLHGGFMVTAFLPRDGRRRAPATPPAPDTRLPAADLMFPTSPTS
                     PTSPDSPTGEETP"
     gene            10336..11010
                     /locus_tag="IE308_RS25385"
                     /old_locus_tag="GCM10018783_51530"
     CDS             10336..11010
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383571.1"
                     /locus_tag="IE308_RS25385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51530"
                     /product="response regulator transcription factor"
                     /protein_id="WP_110629417.1"
                     /transl_table=11
                     /translation="MTSGTIRVLIADDQQMVRQGFTVLLNTQPDIEVIGQAVDGLDAVA
                     RVADLAPDVVLMDIRMPELGGIEATRRIKGATPEIKVLVLTTFDLDEYVYDALRAGASG
                     FLLKDASAEQLADAVRVVAAGDALLAPGVTRRLIAEFARLDGTPRPPLKERVGDLTERE
                     TEVLTLIAQGLSNAEIAQRLVVAEQTVKTHVGRILVKLGLRDRTQAAVFAYESGLVRPA
                     GY"
     gene            complement(11222..11608)
                     /locus_tag="IE308_RS25390"
                     /old_locus_tag="GCM10018783_51540"
     CDS             complement(11222..11608)
                     /EC_number="2.7.8.7"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (4-64). E-value: 6.2e-13. Score:
                     40.7. Matches aSDomain:
                     nrpspksdomains_IE308_RS25390_ACPS.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948600.1"
                     /locus_tag="IE308_RS25390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51540"
                     /product="holo-ACP synthase"
                     /protein_id="WP_190219679.1"
                     /transl_table=11
                     /translation="MIRGVGADVVDVARLSRSLGRTPALADRLFTPAERRSPAGTDRAP
                     ASLAARFATKEAVLKALGGPLGVGWRDIEVTQCASGRPAVHTHGPASAHATRLGITTWH
                     VSLSHDAGIATAVVVAEGADTRQH"
     aSDomain        complement(11417..11596)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS25390_ACPS.1"
                     /evalue="6.20E-13"
                     /label="IE308_RS25390_ACPS.1"
                     /locus_tag="IE308_RS25390"
                     /protein_end="64"
                     /protein_start="4"
                     /score="40.7"
                     /tool="antismash"
                     /translation="VGADVVDVARLSRSLGRTPALADRLFTPAERRSPAGTDRAPASLA
                     ARFATKEAVLKALGG"
     gene            complement(11605..12273)
                     /locus_tag="IE308_RS25395"
                     /old_locus_tag="GCM10018783_51550"
     CDS             complement(11605..12273)
                     /EC_number="2.7.4.3"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016776 - phosphotransferase activity,
                     phosphate group as acceptor [Evidence IEA]"
                     /GO_function="GO:0019205 - nucleobase-containing compound
                     kinase activity [Evidence IEA]"
                     /GO_process="GO:0006139 - nucleobase-containing compound
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014144334.1"
                     /locus_tag="IE308_RS25395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51550"
                     /product="adenylate kinase"
                     /protein_id="WP_110629419.1"
                     /transl_table=11
                     /translation="MRLVLLGPPGAGKGTQAGRLAERFGVPHLSTGDLLREQVAAGTVL
                     GRRAADFIDSGRLVPDALITAIVRGRLHSGRAADGYVLDGYPRSAVQAKALETILAETG
                     TALTAALDLVVDEEEVIRRIGGRQVCLRDSGHIFHLRTAPPIVRGLCDQCGGELYQRSD
                     DRPATVRDRLAVHAEQTAPVARFYADAGLLRTVDAEGTADEVTRRVLDTLGLAGVGGRR
                     "
     gene            complement(12273..13625)
                     /locus_tag="IE308_RS25400"
                     /old_locus_tag="GCM10018783_51560"
     CDS             complement(12273..13625)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389562.1"
                     /locus_tag="IE308_RS25400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51560"
                     /product="MFS transporter"
                     /protein_id="WP_229909050.1"
                     /transl_table=11
                     /translation="MTTPLTSTRAAEAARAGQTIAADRLYAKVARRLLPLLGLLYLVSY
                     LDRSNIAFAAPNGMNEALNLSSSAFGLASGIFFLGYSVVEVPSNMALRRFGARAWLVRI
                     LVSWGVVATLTAFVTSAGQLQTARLLLGVAEAGCLPGIVFYLTLWLPKNVRTRLMAVFF
                     VALPLSTALGAPLSGLIVQYADGLAGLPGWRAMFLLEGVPALLLAVVVWRALPDGPREA
                     RWLTEAERDWLLARVAEDEPEPSVKRRGAGWFTPRTFALGFAYFGIVYGLYALSFFLPT
                     IIAGFQGDNGREFSIVERGLINAVPYALGAVAMLVWGRRAQRTPGAAWTVALPAVLAGV
                     TVPVALYMHGPLATMVVISVCAIGVLSAIPVFWALPTAMLGKEGAAAGIALVNTIGSLG
                     GFAAPYFTGWLKDWTGSVRPGLWLTGGLLICSALIVTALRRGAPRPAEEVV"
     gene            complement(13622..14299)
                     /locus_tag="IE308_RS25405"
                     /old_locus_tag="GCM10018783_51570"
     CDS             complement(13622..14299)
                     /EC_number="2.7.7.87"
                     /GO_function="GO:0003725 - double-stranded RNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0061710 - L-threonylcarbamoyladenylate
                     synthase [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00057.1"
                     /locus_tag="IE308_RS25405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51570"
                     /product="L-threonylcarbamoyladenylate synthase"
                     /protein_id="WP_110629420.1"
                     /transl_table=11
                     /translation="MTVDTYANVAAPTDENLRTAGTLVRTGGVVVAPSDTNLALTLDPW
                     NRAAVERAFAIKRRPPTSPLTLFVRHPQEWEEYTEVPAELREAVRRLTDAFWPGPFNIV
                     LPRNHRIPDHLVCGGPTVALGCLSNPTIQRLIEFTGHPVAMTSANLSGQADGVLVDLDL
                     AVQQIGASVDMVIRGEKQGTTASSTIVTAAELPFKVLRLGDITHAQIKDALGDLAHLLE
                     DAS"
     gene            complement(14343..15812)
                     /locus_tag="IE308_RS25410"
                     /old_locus_tag="GCM10018783_51580"
     CDS             complement(14343..15812)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (65-407). E-value: 4.5e-41.
                     Score: 132.7. Matches aSDomain:
                     nrpspksdomains_IE308_RS25410_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="IE308_RS25410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51580"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_190219680.1"
                     /sec_met_domain="AMP-binding (E-value: 7.6e-46, bitscore:
                     151.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTAQALLGGPAGAGAAPGGVASGGVAPGGASEAGAGWVHPAAS
                     VTEYTPRGVRVLDAAALVAGVAERAEQWAGHGFAPGDRVLVGTGSRLTTLLDVAAAWEA
                     GLVPVLLSDALAPDSYRLLAAATGAVAGRLTPAVARTWAARGGGPLARDAGTVLLRLDG
                     EPGTGAPPYDEPSLVLATSGSTGLPKAVVHRRSRLLRNAGMHWDSVGGLGPGDRYLLSQ
                     SMYFSSAFVCGVLGVLAAGAGLALIEPPFATANWFDAGRGFGATHTALTPHLLMRVLDS
                     GERFPASLRQVTVGGDRLGRTALTELRARGVPDVRTTYGLTEAGPRVATHTPGGTAHDG
                     GLGRPLAGVSWRLGPDGELVVRTPTAQAGGYTDGAYVPYAGDEVPTGDICEELPDGTYQ
                     LVGRARRVTSVAGEKVFLGLVERVLADHPEVSAARVAADGDKGLAAQILPRPGGAGVDA
                     AELRRWCRGRLRAVEVPRTFTLVDPSTQLSK"
     aSDomain        complement(14592..15617)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS25410_AMP-binding.1"
                     /evalue="4.50E-41"
                     /label="IE308_RS25410_AMP-binding.1"
                     /locus_tag="IE308_RS25410"
                     /protein_end="407"
                     /protein_start="65"
                     /score="132.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VAERAEQWAGHGFAPGDRVLVGTGSRLTTLLDVAAAWEAGLVPVL
                     LSDALAPDSYRLLAAATGAVAGRLTPAVARTWAARGGGPLARDAGTVLLRLDGEPGTGA
                     PPYDEPSLVLATSGSTGLPKAVVHRRSRLLRNAGMHWDSVGGLGPGDRYLLSQSMYFSS
                     AFVCGVLGVLAAGAGLALIEPPFATANWFDAGRGFGATHTALTPHLLMRVLDSGERFPA
                     SLRQVTVGGDRLGRTALTELRARGVPDVRTTYGLTEAGPRVATHTPGGTAHDGGLGRPL
                     AGVSWRLGPDGELVVRTPTAQAGGYTDGAYVPYAGDEVPTGDICEELPDGTYQLVGRAR
                     RV"
     CDS_motif       complement(15234..15284)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS25410_0001"
                     /evalue="7.20E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="IE308_RS25410"
                     /protein_end="193"
                     /protein_start="176"
                     /score="15.6"
                     /tool="antismash"
                     /translation="LVLATSGSTGLPKAVVH"
     gene            complement(15809..16549)
                     /locus_tag="IE308_RS25415"
                     /old_locus_tag="GCM10018783_51590"
     CDS             complement(15809..16549)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS25415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_51590"
                     /product="hypothetical protein"
                     /protein_id="WP_190219681.1"
                     /transl_table=11
                     /translation="MTTVFFHGLRGAVRLRAAVVLATPGFRADLSQDHVPEALVTEVAA
                     QDVRGKQDPASLLGALAARELTTASPAGDDDPFSRGVFVSTRRGNQRSVRAFAGALAAG
                     RRSPSTFSVAGYNIVAQSTARELAARGPSVVLAGQRATLDGALFLAALRLGSGAIRTGY
                     VGHVTWLPDATGRSGEGLAVLAAVEHVDSAVSVSEQHVVALDPADLYAPRGTDGPGGAP
                     AAEDFAAAHRVAPLLADARTAGVR"
     gene            complement(16546..16917)
                     /locus_tag="IE308_RS25420"
                     /old_locus_tag="GCM10018783_51600"
     CDS             complement(16546..16917)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS25420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_51600"
                     /product="hypothetical protein"
                     /protein_id="WP_110629423.1"
                     /transl_table=11
                     /translation="MAEPYAPATGWFLGLCGPLEVDGDAARAELVLPAGDLTGAGPLIA
                     VEAMHQIACRLAARARGANRCVPARIDELEITDEAVAPAGAVLEARLLRSGRLSTVRAS
                     LSVQGRVHSSATVRTQEVT"
     gene            complement(16910..17761)
                     /locus_tag="IE308_RS25425"
                     /old_locus_tag="GCM10018783_51610"
     CDS             complement(16910..17761)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="IE308_RS25425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51610"
                     /product="enoyl-ACP reductase"
                     /protein_id="WP_110629424.1"
                     /sec_met_domain="adh_short_C2 (E-value: 3.8e-68, bitscore:
                     225.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTGTLAPATEAPARTGLLAGRRGLVLGVVNQRSIAWGIARRLAA
                     EGAELGFTYRASSAGQWLQRATPRLVADGAEAPYLGHCDVLEEGALERVCAEFAERHGG
                     IDFVVHAVAHADKDELAGGLASTSRSGFTHAMESSVYSLIGLAGAVRPYLTPNSSVLTL
                     SYLGAERVCHGYNVLGVAKAALESAARYLAAELGPSGTRVNVLSAGPVRTLATFGLPNF
                     AASLAQRAGRSPLGRAITTEDVAGTALYLLSDLSSGTTGETVYVDAGYHMMGTWPGDAG
                     HG"
     gene            complement(17794..18558)
                     /locus_tag="IE308_RS25430"
                     /old_locus_tag="GCM10018783_51620"
     CDS             complement(17794..18558)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (17-178). E-value: 4.1e-10.
                     Score: 31.8. Matches aSDomain:
                     nrpspksdomains_IE308_RS25430_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="IE308_RS25430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51620"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_110629425.1"
                     /transl_table=11
                     /translation="MTDSVQTTEGSEPGGRPVAVVTGGARGIGRAVVRRLTQEGYDVEF
                     TYLSSKRAADELTEATGGLARGSQVDGRDAEQVRAFMDRVAATGRLQALVNNQGLTVDR
                     LVNQVTWPELEQLLDTNLGSAVTFTHAALPHMLRHRRGDVVFISSQARRNARVGNAMYG
                     VSKAALTRYAANIALEGARFNVFANVVEPGFVETDLTKVMLDGKDRKKYLQEIPLRRFT
                     NPRDVAQVVAALVTRNPELVGAVLPVAGGAQL"
     CDS_motif       complement(18025..18156)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS25430_0002"
                     /evalue="1.90E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE308_RS25430"
                     /protein_end="178"
                     /protein_start="134"
                     /score="-1.9"
                     /tool="antismash"
                     /translation="HMLRHRRGDVVFISSQARRNARVGNAMYGVSKAALTRYAANIAL"
     aSDomain        complement(18025..18507)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS25430_PKS_KR.1"
                     /evalue="4.10E-10"
                     /label="IE308_RS25430_PKS_KR.1"
                     /locus_tag="IE308_RS25430"
                     /protein_end="178"
                     /protein_start="17"
                     /score="31.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGGARGIGRAVVRRLTQEGYDVEFTYLSSKRAADELTEATG
                     GLARGSQVDGRDAEQVRAFMDRVAATGRLQALVNNQGLTVDRLVNQVTWPELEQLLDTN
                     LGSAVTFTHAALPHMLRHRRGDVVFISSQARRNARVGNAMYGVSKAALTRYAANIAL"
     CDS_motif       complement(18364..18501)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE308_RS25430_0001"
                     /evalue="3.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE308_RS25430"
                     /protein_end="65"
                     /protein_start="19"
                     /score="16.6"
                     /tool="antismash"
                     /translation="VVTGGARGIGRAVVRRLTQEGYDVEFTYLSSKRAADELTEATGGL
                     A"
     gene            complement(18533..18910)
                     /locus_tag="IE308_RS25435"
                     /old_locus_tag="GCM10018783_51630"
     CDS             complement(18533..18910)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS25435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_51630"
                     /product="hypothetical protein"
                     /protein_id="WP_190219682.1"
                     /transl_table=11
                     /translation="MSGNLLGIPVAPDVRHTDGTVTAVLDLDPGWPVFAEHFPGNPVLP
                     GSAAAHLLLGLARRLDPAARGLRDVRFARPLVPPARVRLTATADDAGAVTCTALIEEED
                     GREVVAVRGEVVTDDRQRADD"
     gene            complement(18907..20004)
                     /locus_tag="IE308_RS25440"
                     /old_locus_tag="GCM10018783_51640"
     CDS             complement(18907..20004)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (6-223). E-value: 2.1e-20.
                     Score: 64.9. Matches aSDomain:
                     nrpspksdomains_IE308_RS25440_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019605.5"
                     /locus_tag="IE308_RS25440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51640"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_190219683.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.1e-06, bitscore:
                     22.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.4e-19, bitscore:
                     64.9, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRNLVVTGAGGLVGTALTAALLPAFDRVLLLTAGAPDTERLRRR
                     IGRVLEAAGTEGRDGLLDRVTALPLDGLTPAALRGAGLDSVAQVWNVGASLSYDQDKLA
                     ATVAANTAVPLRLLELCAPDERFFHISTVGVTGPGAPARRETVPEAPVWRPDAVNPYVL
                     SKLLAEHMLDNLRAHTGAPVSMLRLGSVIGPDGHAAVQDNRAGYYTLVEMLAKVVARRA
                     ALTIDAEPGNAPPLAHVDQLAASCAALADRAARGAEVAAYYHLGDQTLTNAAAADAVNA
                     ALGAEVLRLGPPATALDRAYASVNADNVAFMSCGFRFDHAVLDAHVPAAARPRVDADSY
                     ARFVTGQLARLTARRGARREAAVAA"
     aSDomain        complement(19336..19986)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS25440_NAD_binding_4.1"
                     /evalue="2.10E-20"
                     /label="IE308_RS25440_NAD_binding_4.1"
                     /locus_tag="IE308_RS25440"
                     /protein_end="223"
                     /protein_start="6"
                     /score="64.9"
                     /tool="antismash"
                     /translation="VTGAGGLVGTALTAALLPAFDRVLLLTAGAPDTERLRRRIGRVLE
                     AAGTEGRDGLLDRVTALPLDGLTPAALRGAGLDSVAQVWNVGASLSYDQDKLAATVAAN
                     TAVPLRLLELCAPDERFFHISTVGVTGPGAPARRETVPEAPVWRPDAVNPYVLSKLLAE
                     HMLDNLRAHTGAPVSMLRLGSVIGPDGHAAVQDNRAGYYTLVEMLAKVVARRAA"
     gene            complement(20001..21161)
                     /locus_tag="IE308_RS25445"
                     /old_locus_tag="GCM10018783_51650"
     CDS             complement(20001..21161)
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (125-381). E-value:
                     2.1e-34. Score: 111.1. Matches aSDomain:
                     nrpspksdomains_IE308_RS25445_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012337.5"
                     /locus_tag="IE308_RS25445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51650"
                     /product="beta-ketoacyl synthase N-terminal-like
                     domain-containing protein"
                     /protein_id="WP_190219684.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 4.6e-19, bitscore:
                     64.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="APE_KS2 (E-value: 3.6e-55, bitscore:
                     183.0, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGDTPVRVAVAAAGATTCLAGSADATWASVRAGASGLGPLSLFE
                     AGSTGRSGTVGEVAGLAGLTGGPRLAALAEAALTEALRQAEAAGVDRRELAEAWVTVGI
                     SLGDIFEQTGPDVELDHFWDEVAGRLGLTGPVVVLSSACSSGTDAVGYGADLVASGIAP
                     VVLAVGVDSLEPGKYAGHSGLKTMSPDRCRPYDADGDGTTLAEGACALVLTAADRLPGV
                     PFAELRGWAASTDIDALTSPDLSGEGAARMLRAALAMAGATPADVAHLNGHGSGTPVND
                     ALEAAVYAAVFPERDVAVSGTKGALGHSLGATGAVEALLTAYALRERVAPPTAGLRTPH
                     DRWAGAPVATGEAPLPLDADRALGVSVTYGFGGANSCVVLTAGGAA"
     aSDomain        complement(20019..20786)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS25445_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="2.10E-34"
                     /label="IE308_RS25445_PKS_KS.1"
                     /locus_tag="IE308_RS25445"
                     /protein_end="381"
                     /protein_start="125"
                     /score="111.1"
                     /tool="antismash"
                     /translation="VAGRLGLTGPVVVLSSACSSGTDAVGYGADLVASGIAPVVLAVGV
                     DSLEPGKYAGHSGLKTMSPDRCRPYDADGDGTTLAEGACALVLTAADRLPGVPFAELRG
                     WAASTDIDALTSPDLSGEGAARMLRAALAMAGATPADVAHLNGHGSGTPVNDALEAAVY
                     AAVFPERDVAVSGTKGALGHSLGATGAVEALLTAYALRERVAPPTAGLRTPHDRWAGAP
                     VATGEAPLPLDADRALGVSVTYGFGGANSCVVLT"
     gene            complement(21158..21571)
                     /locus_tag="IE308_RS25450"
                     /old_locus_tag="GCM10018783_51660"
     CDS             complement(21158..21571)
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024675.5"
                     /locus_tag="IE308_RS25450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51660"
                     /product="thioesterase family protein"
                     /protein_id="WP_190219685.1"
                     /sec_met_domain="4HBT_2 (E-value: 1.8e-09, bitscore: 33.5,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILSLEHPVRDAEVDEFEVVHFSNYLKWYSNALKEFLGRYSSPPG
                     FFGEGVEIRVARVRASYSNSALRNDTVQVSVTRAENLGRALQLHFRAEARGKLLARAEL
                     NLVFVQKEPYRLLPVPEAFARQLPAPKTAERAA"
     gene            complement(21612..21893)
                     /locus_tag="IE308_RS25455"
                     /old_locus_tag="GCM10018783_51670"
     CDS             complement(21612..21893)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (28-87). E-value: 2.5e-11.
                     Score: 35.7. Matches aSDomain:
                     nrpspksdomains_IE308_RS25455_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1147: putative acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="IE308_RS25455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51670"
                     /product="acyl carrier protein"
                     /protein_id="WP_110629430.1"
                     /sec_met_domain="PP-binding (E-value: 2.4e-10, bitscore:
                     36.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTANETFAADAVAAHLKQFIVDALFIDMEPAEITDDMLLGTDV
                     GVDSLGFAELLAHLEDEYGISVTDGEFVPDNFATVGRIVALVGRKLAG"
     aSDomain        complement(21633..21809)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS25455_PP-binding.1"
                     /evalue="2.50E-11"
                     /label="IE308_RS25455_PP-binding.1"
                     /locus_tag="IE308_RS25455"
                     /protein_end="87"
                     /protein_start="28"
                     /score="35.7"
                     /tool="antismash"
                     /translation="DMEPAEITDDMLLGTDVGVDSLGFAELLAHLEDEYGISVTDGEFV
                     PDNFATVGRIVALV"
     gene            complement(21974..22402)
                     /locus_tag="IE308_RS25460"
                     /old_locus_tag="GCM10018783_51680"
     CDS             complement(21974..22402)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015862.5"
                     /locus_tag="IE308_RS25460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51680"
                     /product="heme-binding protein"
                     /protein_id="WP_190219686.1"
                     /transl_table=11
                     /translation="MSAQVRQRAALSNELARQLVDAALKAAAELGQPSTVAVVDESGHL
                     NALARMDGAALLTLEIAQDKAYTAAGFGLPTDQWHEFIKDDQPLAMGAPTGIRRLIVFG
                     GGLPIVVDGQVVGGIGVSGGHWSDDIKIAKAALATLED"
     misc_feature    22402..22419
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.54"
                     /tool="antismash"
     gene            complement(22449..23654)
                     /locus_tag="IE308_RS25465"
                     /old_locus_tag="GCM10018783_51690"
     CDS             complement(22449..23654)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS25465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_51690"
                     /product="hypothetical protein"
                     /protein_id="WP_190219687.1"
                     /transl_table=11
                     /translation="MLSAPRLFTGYRVLSRSYFHLTILFVFLYDRGLSLPTVELTLAVY
                     GAALALAGPVTKPLAARLSLTGAVATGEWLKAAGLVLLALPGGLPVAIAGQIIAALGFS
                     LASGTDSALLAEVCRRDGADARAWEGRSGSLTFAAALVAGVLGAILYQASHTAPFYLSA
                     AMSALAALTAPLVGRGLEPAVKPTATAPKDTPAQRAKGPAYAAVLRWSAYYTVVRAFVL
                     ALFIGFLPYLLYLRLHVSLPVFGLVLGSYTLSGYFTARYGRAAVDRFGARATATASASL
                     AGAGLLILLWQPNTAGAAVATLALGAGVGAVRPVAVGAIGELLADRPAAEKAAALRANE
                     ARFAAVNTLLILLAGLLLDRVGFPQLLLGVVVGYLALAAAAVVALPRTAAADTPAKAPV
                     AV"
     gene            complement(23689..24282)
                     /gene="leuD"
                     /locus_tag="IE308_RS25470"
                     /old_locus_tag="GCM10018783_51700"
     CDS             complement(23689..24282)
                     /EC_number="4.2.1.33"
                     /GO_component="GO:0009316 - 3-isopropylmalate dehydratase
                     complex [Evidence IEA]"
                     /GO_function="GO:0003861 - 3-isopropylmalate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470070.1"
                     /locus_tag="IE308_RS25470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51700"
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="WP_190219688.1"
                     /transl_table=11
                     /translation="MEPFVSHTGRMLPLRRSNVDTDQLIPVRFLKRLTRTGYADGLFAV
                     WRTDPEFVLNQPRHEGATVLVAGPEFGTGSSREHAVWALLDHGFRVVLSPRFADIFRGN
                     SLKNGLLTIQLPDEVIAELWRRAEEFPEEPVTVDLAALEVRAGELTVPFELDPYHRMRL
                     MEGLDEIDATLRHADRIRAYEDRRPSFKPTVTAA"
     gene            complement(24285..25709)
                     /gene="leuC"
                     /locus_tag="IE308_RS25475"
                     /old_locus_tag="GCM10018783_51710"
     CDS             complement(24285..25709)
                     /EC_number="4.2.1.33"
                     /GO_component="GO:0009316 - 3-isopropylmalate dehydratase
                     complex [Evidence IEA]"
                     /GO_function="GO:0003861 - 3-isopropylmalate dehydratase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145098.1"
                     /locus_tag="IE308_RS25475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51710"
                     /product="3-isopropylmalate dehydratase large subunit"
                     /protein_id="WP_110629434.1"
                     /transl_table=11
                     /translation="MPGQTLAEKVWDAHLVHRAEGEPDILYIDLHLLHEVTSPQAFDGL
                     ELRGRKVARPDLTLATEDHNTPTQDIGLPIADPTSRAQVEAIRKNSEKFGVTLYPLGDP
                     GQGIVHVIGPETGLSQPGTTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLRLRP
                     FRTMAVNLRGTPRPGVTAKDIILAVIGKIGTGGGQGHVIEYRGEVIAGLSMEARMTICN
                     MSIEAGARAGMIAPDDTTFAYLKGRKHAPRGADWDAAVEYWRTLRTDEDAVFDKEVDVD
                     LDTLTPYVSWGTNPSQVAPLDSLVPAPESFADPAQRAACERALAYQGLTPGTPLAGIPV
                     DAVFLGSCTNGRIEDLRAAAEVLRGRRVDPRVRMLVVPGSDRVKAAAEAEGLDRVFSEA
                     GAEWRNAGCSMCMAMNPDFLQPGQRAASTSNRNFEGRQGAGSHTHLVSPAVAAATAVAG
                     ALASPESLPEPVFAEV"
     gene            25886..26794
                     /locus_tag="IE308_RS25480"
                     /old_locus_tag="GCM10018783_51720"
     CDS             25886..26794
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.5"
                     /locus_tag="IE308_RS25480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51720"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_162655564.1"
                     /transl_table=11
                     /translation="MSIVAERHRPLTDRRLGHRLLLCVQEARPLVQAAFVLRFALGALC
                     TLGSGRAPGLTVLAGAAAWWAATTCAYLFNGLMDLPEDRANGSSRPLAGGRLDVRTARA
                     GVVALAVTALALSLFAPRTTGCVLVFLVLGYLYSAPRGAAKLRAWSASCVTTAATFATY
                     LGGALSTGRTPSATALLFGAVMSLWVGLIGAVAKDLGSTGGDALAGRRTLAVVRGEAAT
                     RTFCALAALCLAQFSLLGAPWTTTPVPLTTGALALAVGATLLTARCLAPRTVAPRSPYR
                     VAMATQYGVHLATAAALLLGM"
     misc_feature    26048..26050
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    26861..26874
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.58"
                     /tool="antismash"
     misc_feature    26889..26905
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    26897..26913
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.44"
                     /tool="antismash"
     gene            26980..28080
                     /locus_tag="IE308_RS25485"
                     /old_locus_tag="GCM10018783_51730"
     CDS             26980..28080
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554096.1"
                     /locus_tag="IE308_RS25485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51730"
                     /product="sensor histidine kinase"
                     /protein_id="WP_190219689.1"
                     /transl_table=11
                     /translation="MSATAGSPPERRAAVVEAVIAAYAAGLREADSALVRNDRIWNSAR
                     DQARDILTECLAALHGEQVQVAMEAELTSMALGMRRAFEQIPPIDSLFAAHVLFEVGTD
                     ALVEEARAFPAGTGMSRLTRAVRMLHSSISTRVRAAAIGYEASTLRGVGAANTARRDQL
                     ARDIHDHIGSSLALALRCLDLYEADLAAGGSAQSRIADARQALRDTFRFTRSLVSGLRS
                     YELRDSLQAEISSYTQAATDGAQVVVGINGDEAWLPADRREEIFLVVRECLRNAFTHAA
                     ASRIDVDVTIAPDCVACTVEDDGRGFDPAAPATGRSGGMSSMRERVTGLGGTLRVASYP
                     GIGTRVHFQVPLPEVAAVDLVEREHT"
     gene            28331..28948
                     /locus_tag="IE308_RS25490"
                     /old_locus_tag="GCM10018783_51740"
     CDS             28331..28948
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554095.1"
                     /locus_tag="IE308_RS25490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51740"
                     /product="response regulator transcription factor"
                     /protein_id="WP_229909053.1"
                     /transl_table=11
                     /translation="MAGGRREIRILAADDHSLLRGALCELLDLHDGLTVVAQAGDGPSA
                     VALAAEHQPDIVLLDVEMPGPGPLQTVRALRERAPQARIVVLTMHDDARLIESLLKAGT
                     SAYLHKEVDREILVSAIRSAMAGGKTTFLPRPVPPSGPHPLTDRERELMTLVAEGLSNR
                     QIGTRLGIAEGTVKRHLRNVFDKLGAASRLDAVNRLREFEPF"
     gene            29060..30433
                     /locus_tag="IE308_RS25495"
                     /old_locus_tag="GCM10018783_51750"
     CDS             29060..30433
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437239.1"
                     /locus_tag="IE308_RS25495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51750"
                     /product="sensor histidine kinase"
                     /protein_id="WP_190219691.1"
                     /transl_table=11
                     /translation="MAETTKTHPTTSGPGEGDHPAYVPRSPEFRAAAQALRGMRQDLLH
                     DVFAYRPLPRLAADAPFVRRFPAPLRRHAVWARHALVLLLAWATLAAGASTGYDLASPV
                     YVVTSVIPAAAVVLTLLRPVAAFWLSLGSAALLAVLGVDWDGWPFQPAGFAGHLSVLTV
                     VALRTRPRTAAWMWLVTAAYGVLTGPFAAYPYGGSDSVEFLFLSALVLLAVTVWHIRRD
                     AEEEVTAQQTVTEHERSRRTLLEERTTIARELHDVVAHHMSVVAIQAEAAPYRVENPPP
                     ELAKAFATIRENAVAALTELRRVLGVVRAEDYEAPDAPQPTLADLDALLANVREAGLTV
                     DRTVTGAVRELPQGVELSAYRIVQEALSNTLRHAPGATARVEIGYVIGGLGLRVVNTPP
                     PAPAPSAASPGAGHGLTGMRERVTMLNGEMTAGPTPEGGYEVTVYLPARTPGEDGGTA"
     gene            30430..31095
                     /locus_tag="IE308_RS25500"
                     /old_locus_tag="GCM10018783_51760"
     CDS             30430..31095
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013001893.1"
                     /locus_tag="IE308_RS25500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51760"
                     /product="response regulator transcription factor"
                     /protein_id="WP_110629439.1"
                     /transl_table=11
                     /translation="MTIRVLVADDQMMVREGFSVLLNAMPDIEVTGEAVNGREAVAKVR
                     ELAPDVVLMDIRMPELNGIEATREIVAADGTAKVLVLTTFDLDEYVYQALRAGASGFLL
                     KDASARQLADAVRVVAAGEALLAPSVTRRLITEFSRLSEPSHPLSGAHAAYGDLTDRET
                     EVLVLIAQGLSNAEIAGRLVVAESTIKTHVSRILVKLGLRDRTQAAVFAYEARLVTPG"
     gene            31126..31770
                     /locus_tag="IE308_RS25505"
                     /old_locus_tag="GCM10018783_51770"
     CDS             31126..31770
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268585.1"
                     /locus_tag="IE308_RS25505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51770"
                     /product="hypothetical protein"
                     /protein_id="WP_190219692.1"
                     /transl_table=11
                     /translation="MTTLAGYENRPLADGGPLLGRPGFWPNHLWAPCCQEAGAGPERFG
                     ADGADVDALYETLTDPGRWPVFRVPCADGREVTVVYHNLVDDPGVAYLLTAPGDSGPRP
                     LRALTWRELDRAAHGPLPATGADGITDPAARLLLLFPLLDDHAVPDEAAATVESALVAV
                     GAPQDTAPATARHLLDHAAGEVWHDPEWDSPLSGAEPEAARSPWSDPGPPR"
     gene            31780..33000
                     /locus_tag="IE308_RS25510"
                     /old_locus_tag="GCM10018783_51780"
     CDS             31780..33000
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006141953.1"
                     /locus_tag="IE308_RS25510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51780"
                     /product="cytochrome P450"
                     /protein_id="WP_190219693.1"
                     /sec_met_domain="p450 (E-value: 3.9e-20, bitscore: 67.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDVARLAFDPWDPAFLADPYPAYAELRARGRVLYYEPTDQWLVP
                     RHADVSALLRERRLGRTYLHRFSHEEFGRTPPPAEHEPFHTLNDHGMLDLEPPDHTRIR
                     RLVSKAFTPRTVERLKPYVEQLAGDLVARLVEAGRGDLLTDVAEPLPVAVIAEMLGIPD
                     ADRPLLRPWSADICGMYELNPSAEAADRAVRASVEFSDYLRDLIAARRREPGDDLISGL
                     IAAHDEGDRLTEQEMISTAVLLLNAGHEATVNATVNGWWALFRNPAQLAALRADHSLVP
                     TAVEELMRYDTPLQLFERWVLDDLEIDGTTIPRGAEIAMLFGSANHDPDVFDVPDRLDL
                     TRRDNPHISFSAGIHYCIGAPLARIELAASMRALLTRAPTLTLAAEPERKPNFVIRGLE
                     GLSVEVG"
     gene            33088..33681
                     /locus_tag="IE308_RS25515"
                     /old_locus_tag="GCM10018783_51790"
     CDS             33088..33681
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437242.1"
                     /locus_tag="IE308_RS25515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51790"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_110629442.1"
                     /transl_table=11
                     /translation="MTVMAERASSQLSVSMFERIAEFAEREDEAVRFEFIDGRIGLNKV
                     TNGNHGEIAMWLVFQCKQARPELTLNTTQGLKVEAYRKGRARPDGVLAPVGHFAGKGDW
                     ADPDGVLMAVEITSYDADTHNRDRIEKPRAYAEAGIPVYLLIDRDRLSVLVHSDPDFED
                     GYRDIHVVRLGGKVTLPEPVGIELDTAHLKQYLD"
     gene            complement(33724..35328)
                     /locus_tag="IE308_RS25520"
                     /old_locus_tag="GCM10018783_51800"
     CDS             complement(33724..35328)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999308.1"
                     /locus_tag="IE308_RS25520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51800"
                     /product="ABC transporter permease"
                     /protein_id="WP_190219694.1"
                     /transl_table=11
                     /translation="MTATLAVRRSGGGRQLAGTGTLLRFALRRDRVMTPVWIAVNALMV
                     LSMPNTLRNLYATDAERADLLRQMAANSSLRAMVGPVFGDSLGALTAWRIGVYAGALAA
                     VMSLLIVVRHTRDEEESGRAELVASGAVGRRASLTAALLAAAVADAVLAVLLAAGLARL
                     GAAGAVAFALGAAATGLVFATTAAIAAQLTESARLARGIAAGVLGAAFVLRAAGDAATD
                     DGSSVLTWLSPLGWPENVRAYAGERWWVLLLSGAAVAVQAAVAYGLAGRRDVGMSFLPT
                     RPGPAAGRLASAGALAWRLQRGGVLGWSIGFFLAGVVYGGMTEGAADLVGDNERAREIF
                     ERMGGQSGLTDAFLASMIGVMGLVAGLFVVASVLRLYGEETSGRAEPVLAGAVGRLRWA
                     SGHLLIAFAGVVWLMLLTGLGFTAGYGGEAGPILAACLVQVPAVWVVGGLAVLLYGLLP
                     RAAVAAWAVAGAVLLLGWIGPALDVPQTVLDLSPFGHLPKLPGGEMRWGPAGVLLGVAA
                     VCTAAGLAGVRRRDLES"
     gene            complement(35325..36218)
                     /locus_tag="IE308_RS25525"
                     /old_locus_tag="GCM10018783_51810"
     CDS             complement(35325..36218)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991822.1"
                     /locus_tag="IE308_RS25525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51810"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190219695.1"
                     /transl_table=11
                     /translation="MTKAITVSGLHKAFGRTHALDGLDLEVEAGEVHGFLGPNGAGKST
                     IIRVLLGLLRADSGAAHVLGRDPWADAVEVHRRIAYVPGDVTLWRNLSGGEIIDLFGRL
                     RGGLDPKRRAELVERFELDPTKKGRTYSKGNRQKVALVAAFASDVDLLILDEPTSGLDP
                     LMEEVFRRCVEEERERGRTVLLSSHILSEVEELCDRVSIIRKGRTVETGSLADLRHLTR
                     TSVTAELAGPPDGLARLPGVHDLDVRGSRVRLQVDTGHLDAVLRRLSESGVRSLTSTPP
                     TLEELFLRHYQDEVTA"
     misc_feature    36235..36249
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.22"
                     /tool="antismash"
     misc_feature    complement(36239..36254)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    complement(36244..36258)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.39"
                     /tool="antismash"
     misc_feature    36246..36259
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.24"
                     /tool="antismash"
     gene            36323..36817
                     /locus_tag="IE308_RS25530"
                     /old_locus_tag="GCM10018783_51820"
     CDS             36323..36817
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135108.1"
                     /locus_tag="IE308_RS25530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51820"
                     /product="GbsR/MarR family transcriptional regulator"
                     /protein_id="WP_110629445.1"
                     /transl_table=11
                     /translation="MTEPKEAGRDPETLSRFVEHFAAQLVEAGLPRMPARVFAALLASD
                     TGTLTSAELGEQLRISPAAVSGAVRYLSQVHMLSREREPGSRRERYRVHSDQWYEALTN
                     REAVIKRWEDALREGITSLGPTTPAGRRLTETLAFFEFIEKDVAGMMERWRAHREERFG
                     A"
     gene            36874..37494
                     /locus_tag="IE308_RS25535"
                     /old_locus_tag="GCM10018783_51830"
     CDS             36874..37494
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032044.1"
                     /locus_tag="IE308_RS25535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51830"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_190219696.1"
                     /transl_table=11
                     /translation="MTLMTVRPMASGSDPFSFEELLDALDELDAPGFRAEVIRGSIVLS
                     PWSKGYYRRVMRAVLEQLEPRLPDGHEIELAPFLYVFPGEERAYGPDIHAAPREAFETT
                     SNRLDGEALSFVAELTSASTRDDDLTDKVLVYGRAGIPVYLVLDMQEEQATVFWTPSPT
                     KGYESHCTRPFGEKLPIPAPFDCTLDTDGFRAPAADQDQNTAS"
     gene            complement(37510..38364)
                     /locus_tag="IE308_RS25540"
                     /old_locus_tag="GCM10018783_51840"
     CDS             complement(37510..38364)
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032042.1"
                     /locus_tag="IE308_RS25540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51840"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_190219697.1"
                     /transl_table=11
                     /translation="MATYPTSEQLLVIVDPIARRTDGEAVRIAKDVLSAGAATKLCLPD
                     DPEEFARALARRGSRRPVVIGDDRALVRAVSVLHRQRELAGSVLSVVPVGPAVTVARSL
                     GVPTGAVAAARAVLDGAVRRLDVLVDDSDGVVLGTVGIPPLRERMPEAEADPEGARPWL
                     RTCQSLVRTLVPLRPVRTLPAAGPSRLRVEVDGVTVVDLDQPVEAVSLTPGTSGTAFVE
                     VRPSSVGAEASPLLSEGRTVSVSGADFRYHADDRVSGPVRRRTWTVLEGALGITLPAGP
                     GAR"
     gene            38560..39843
                     /locus_tag="IE308_RS25545"
                     /old_locus_tag="GCM10018783_51850"
     CDS             38560..39843
                     /EC_number="6.3.4.4"
                     /GO_function="GO:0004019 - adenylosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975310.1"
                     /locus_tag="IE308_RS25545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51850"
                     /product="adenylosuccinate synthase"
                     /protein_id="WP_110629447.1"
                     /transl_table=11
                     /translation="MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVV
                     GDQKYALHLLPSGILSPGCTPVIGNGVVVDPSVLLSELSGLNERGVDTSKLLISGNAHI
                     ITPYNVTVDKVTERFLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILQQKVEAA
                     LDVKNQILTKLYNRRAIAADQVVEELLGYAEKIKPYVADTVLVLNQALEDDKVVLFEGG
                     QGTLLDIDHGTYPFVTSSNPTAGGACTGAGVGPTKISRVIGILKAYTTRVGAGPFPTEL
                     FDEDGEALRRIGGERGVTTGRDRRCGWFDAVIARYATRVNGLTDFFLTKLDVLTGWEQI
                     PVCVAYEIDGKRVEELPYSQTDFHHAKPVYEMLPGWSEDISKAKSFSDLPKNAQAYVKA
                     LEEMSGAPISAIGVGPGRDETIEINSFL"
     gene            39950..40144
                     /locus_tag="IE308_RS25550"
                     /old_locus_tag="GCM10018783_51860"
     CDS             39950..40144
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547873.1"
                     /locus_tag="IE308_RS25550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_51860"
                     /product="hypothetical protein"
                     /protein_id="WP_110629448.1"
                     /transl_table=11
                     /translation="MTRREVRCLGPYGGEVEDTGCGEPARFELVRHRRPPLHLCPVHLG
                     PALLLADGVLWPPEIRLIA"
ORIGIN
        1 cccccgaggt ctacaacgag atgctcgacc gggcgaaggc aggcaagttc gcctacccgg
       61 ccatcaacgt cacctcgtcg cagaccctgc acgcggctct gcgcggcttc gccgaggccg
      121 agagcgacgg catcatccag atctcgaccg gcggcgccga gttcctgggc ggccagcaca
      181 acaaggacat ggtgaccggc gcggtcgccc tggccgagtt cgcgcacatc gtcgcgcaga
      241 agtacgacat caccgtcgcc ctgcacaccg accactgccc gaaggacaag ctcgacgggt
      301 acgtccgccc gctgctcgcc gtctccgagg agcgcgtcgc ccgcggcgag aacccgctct
      361 tccagtccca catgtgggac ggctcggccg agaccctggc cgacaacctt cagatcgcgc
      421 aggagctgct ggcccgcgcc gccgccgcga agatcatcct ggaggtcgag atcaccccga
      481 ccggcggtga ggaggacggc gtctcgcacg agatcaacga ctccctgtac accacggtcg
      541 acgacgcgat ccgcaccgcc gaggcgctcg gcctgggcga gaagggccgc tacctgctcg
      601 ccgcgtcctt cggcaacgtg cacggcgtgt acaagccggg caacgtggtc ctccgtcccg
      661 agctgctgaa ggagctgaac gacggcgtcg ccgccaagta cggcaaggcc tcgccgttcg
      721 acttcgtctt ccacggcggt tccggctcca cggtcgagga gatccacacc gcgctggaga
      781 acggcgtggt caagatgaac atcgacacgg acacgcagta cgccttcacg cgtccggtcg
      841 tcgaccacat gttcaagaac tacgacggcg tcctgaaggt cgacggcgag gtcggctcca
      901 agaagaccta cgacccgcgc acctggggca agctcgccga ggcgggcatg gcccagcgcg
      961 tcgtcgaggc ctgtcagagc ctccgctccg ccggtacgaa gatcaagtaa ggcaggcggt
     1021 catggcgggc cggggcgagg gggccggagg gttccccgcc ccggcctccg tgcgtctggc
     1081 ctcgcccacc gggcggtggc tcgtcctcac caccgtcctc ggctccagca tggccctgct
     1141 ggactcgacc gtcgtcaacg tcgcgctgcc ccgcatcggc cgcgacctcg gcgcggacct
     1201 cgccgccctg cagtggacgg tcaacgccta cctcgtcacg ctggccgggc tgatcctgct
     1261 cggcggggcg ctgggcgacc ggtacggccg ccggaaggtc ttcgtcgtcg gcgtcgtctg
     1321 gttcgccgcg gcctcgctgc tgtgcgggct cgccccgaac gccggggtgc tgatcgcggc
     1381 ccgtgccctc cagggcgtcg gcggcgccct gctcaccccg ggctcgctcg ccctcatcca
     1441 ggcctccttc caccccgacg accggggccg ggccgtcggc ctgtggtcgg ggttcggcgg
     1501 catcggcgcg gccgtcggac cgttcctcgg cggctggctg gtggacgggc ccggctggcg
     1561 ctgggtgttc ctgctgaacg tgccgctggc cgcggtgtgc gtgccggtgg cgctgcggca
     1621 cgtccccgag tcctccgacg gacgcgccga ccacggccgg ttcgacgcgc tcggcgccgg
     1681 gctcggcgcg ctggcgctcg cgctgctgac gtacgccctg atcgaggccc gcgaggggtc
     1741 cctggtggtg gcggtgacgg gggtcgcggg tgtggcggcg gccgtcgcgt tcgtcgtcgt
     1801 cgagcggcgg cggcccgacc cgatgatgcc gctcgacgtc ttccgctccc gccagttcac
     1861 cgccgtcaac ctggtcacgc tgtgcgtgta cgcggccttc ggcggcttct tcttcctcgc
     1921 cgcgctccag ctgcaggtcg tggccggctg gtccgcgctc ggcgccggta cggcgctgct
     1981 gccgacgacc gttttgatgc tgctgttctc ggcgcgctcc ggcgccctgg ccgaccggat
     2041 cggcccgcgc atcccgctca ccgtcgggcc gctgctgtgc gcggcggcga tgctgctgat
     2101 gctgcgggtc ggcgcggacg cggactacct gaccgacgtg ctgcccgcgc tgctggtgat
     2161 gggcaccggc atggtcaccc tggtggcccc gctgaccgcg accgtgctgg cctcggtcga
     2221 cagcgcgcgg gccggcctgg ccagcggcat caacaacgcg gcggcgcggg cggccggcct
     2281 ggtcgccgtg gcggcgctgc cgctgctcgc cgggatgggg ccggaggcgt accgctccgc
     2341 caccgagttc gaccgcgcgt tcgacaaggc gatggtgtgg tgcgccgggg tgctggtgct
     2401 cggcgcggtg gtggccgtcg cgacggtacg ccgcccggtg cccgggtgcg cgcgcccgga
     2461 gtgccgccgg cacggcagcg tgctggcacc tccgctggag ggacgtaagc cctcggaatc
     2521 gaaccggtga ctgagggcgc gtgggcccgc ggagtcggac cggtgaggga gggcgcgcag
     2581 aaccgcgcag tcggaccggt gagggagggc gcgcaggccc gcgcgatcga accggtgaca
     2641 gaggggacgc cggccctcgg aatcggaccg gtgacagact ggaacccatg accatccacg
     2701 agaacctcct cgggggcccg cccccgaccc gactgcccga cgaccccgag ccgcgtgagc
     2761 tgctggccgc cggcaccccg gccgccgacg tcgccgcgaa gtacccgacg tcctcgctgg
     2821 cctgggcccg gctggccgac gaggcgttcg agcggggctc ggtcgtcgag tcgtacgcct
     2881 acgcgcgtac cggctaccac cgcggcctgg acgcgctgcg ccgcaacggc tggaagggcc
     2941 acggtccgat cccctgggag cacgagccga accgcggctt cctgcgcgcc ctgcacggcc
     3001 tcgcccgcgc cgcgcaggcg atcggcgagc aggaggagta cgagcgctgc gcgcagttcc
     3061 tgaaggactc ctcggagacc gcggcccaga ccctcggctg agcgcccggc cgggccgggt
     3121 gcgaccgtac ggcccgtctg tgaccaggcg ggccttgcgg tgaccgggcc cattgcggag
     3181 gatgcgggtg gggaccgggg cccccgtgcc ggtaacggca ggggcggacc gctacccgga
     3241 gtacacagca ggagacagcg atgtcccaag aggctcagga cattcaggag cccgagactc
     3301 cgcatctcga tttcgaaggc acgacgccgt acgaggacta cgtcaaggcg gacgtgctca
     3361 cccatctcca gcacaccctc tccgacgatc ccggagagat ggtcttcctg gtcacgaccc
     3421 aggtgatgga gctgtggttc accgtcatcg tccacgagtg ggagacggcc gcgcgtgccc
     3481 tgcgctcgga cgacgtgccg accgcgatcg ccgcactgaa acgatccgtc cgtgagctgg
     3541 aggcgctgaa cgcctcctgg aagccgctag gccagctcac cccgcagcag ttcaactcct
     3601 accggtccgc cctcggcgag ggctccggct tccagtcggc gatgtaccgc cgtatggagt
     3661 tcctgctcgg cgacaagtcc gcctccatgc tcgtcccgca ccgcggcgcg ccccgcgtcc
     3721 acgccgagct ggagaaggcg ctgcacgaac cgagcctgta cgacgaggtc ctgcggctcc
     3781 tcgcgcggcg cggccacgcg atcccggacg agctgctcac gcgtgacgtc tcccgccgct
     3841 acgaaccgtc ggaggcggtc gaggcggcct ggacggccgt ctacgcgggc gaccccggcg
     3901 acgacgtggc ccgcctcggc gaggcgctga ccaatgtcgc cgaactggtg tggcgctggc
     3961 gcaacgacca cctcgtcgcc acccgccgcg ccatgggcgc caagcccggc accggcggct
     4021 cggccggagt ggcgtggctg gagaagcgcg cgcagaagaa cgtgttcccg gagctgtgga
     4081 cggcgcggtc ccatgtctga accgacgagt gaactcgccc tgagggcgga gaagtccgac
     4141 gccgccgacg aactggcggg cctgcgcgag cggttcgtcc tcgacgacac cgtctacctc
     4201 gacggcaact cgctcggcgc gctgcccgcg cacgtgccgg accgggtggc ggacgtcgtc
     4261 cgccgccagt ggggcgagct gcgcatccgc tcctgggagg agagcggctg gtggacggcg
     4321 ccggagcgga tcggtgaccg gatcgccccg ctggtgggcg cggcacccgg ccagatcgtg
     4381 gtcggcgact cgaccagcgt caacgtcttc aaggcgctcg tggccgccgt ccggatggcc
     4441 ggtgagggcc gggacgagat cgtcgtcgac gcgtcgacct tccccacgga cgggtacatc
     4501 gccgagtcgg cggcccggct gaccgggtgc gccctgcgcc cggtcctccc ggccgaggtg
     4561 cccggtgtcc tgggtgagcg caccgccgcc gtcctgctca accacgtcga ctaccgcacc
     4621 ggccgcctgc acgacctgcc gtccctgacg gcggcggtcc acgcggccgg cgcgctcgcc
     4681 gtgtgggacc tgtgccacag cgcgggcgcc ctgccggtcg ggctcgacga gcacggcgtg
     4741 gacctcgccg tcggttgcac gtacaagtac ctcaacggcg gcccgggcgc cccggcgtac
     4801 ctgtacgtac gacgggaact ccagccccgc ttcgactcgc cgctgcccgg ctggaactcc
     4861 cacgcggagc ccttcgggat gcgcccggag tacgcgccgg ccgagggcgc cccgcgcggc
     4921 cgggtcggca cgccggacat cctctccatg ctcgcgctgg aggccgccct ggacgtgtgg
     4981 gacggggtgt cggtcgaggc ggtgcgcgcc aagtcgctcg cgctgacgga cttcttcctg
     5041 gagtgcgtcg ggcggtacgt ccccgagggc cgcgtcgagt gcgtgacgcc cctcgcccac
     5101 gcggagcgcg gcagccaggt cgcgctgcgc tgcccggacg ccggggacgt gatgcggcgg
     5161 ctgatcgaac ggggcgtcgt cggcgactac cgcgcccccg acgtcctgcg cttcggcttc
     5221 accccgctgt acgtcggttt cgccgacgtg gagcgggcgg cgcgggtgct ggcggagacg
     5281 ctggcggaga cggtggaggg cacctcgccc ggcttctgac cagccgtatg cgacgtcggc
     5341 gaggccctgc cccctacccg gtgggacagg gcctcgccgt gctttccggt cacctggccg
     5401 tggcgaaccg tttacccctc accctgagtg acgtccaggc tgtccgtgca cgtcaccggc
     5461 ctgataacgt cccggccaac ggcctgattc tctcctggtc cgtccccgcc ggttcatcaa
     5521 gtacgttttg ccgctgagag gttggagcat gccggacgac gtcgcagcag cccgggccgc
     5581 cgccgaggag gagtcggcct tctcgcaccc gcccgtcgct cccgacacca gcgccgccta
     5641 cggcgaccac cccgaccagg tgatcgactt ctacgccccg cgcgccgagc ggggccccgg
     5701 tggaccggcc ccgctggtcg tcgtcctgca cggcggcgcc tggcgcgccc cttacgaccg
     5761 gcggcacgtc agcccgttcg ccgccttcct ggccgggcgc ggcttcggcg tggccctggt
     5821 ggagtaccgg cggggcacgg agggcgacgc gacgctggcc gggcgctggc ccgacacctt
     5881 cgacgacgtc gccgccgcgc tggacgcgct gcccgccctg gcccggcagg cgctgccgca
     5941 gacagacccg cgccgcacgg tcgtcaccgg ccactcggcc ggcggccacc tcgccctgtg
     6001 ggcggcggcc cggcacgtcc tgcccgccgg cgccccctgg cgcctggacg gcccgccgca
     6061 gctgcggggc gtggtcgcgc tcgccccgat cgccgacttc acggtcgcgg agaagctcga
     6121 cgtgtgcggg aacgcggcgc tccaactcct gggcggaaac gagctgttcg ccgaacggca
     6181 gccgtacgcc gaccccgccc tgctcctccc gaccggcatc gcgacgaccc tcgtccaggg
     6241 ccgcgccgac ctcgacgtcc cccaggcggt cgccgaggcc tacgcggacg cggcggccaa
     6301 ggcgggcgag gtggtcggcc tgaccctgct ggaggacgtc gggcacttcc cgctgatcga
     6361 cccggtggcg gacgcgtgcg cggtggtggc ggaggagatc gcacagttgg cgtggtgacg
     6421 ccgtggctct cggagggctc cgaccgcccc gcttgcgggc gggccccgtc gtacccgtaa
     6481 tacctgagag ctacgcggcg gatgagctcc ccggcgggac gcggacgagg cgtcgcgctc
     6541 cgtaacttcc ttgtcggacg ggcccgatgg gcgggccgga cggcggggag acgacgatgg
     6601 gtgcggggga gcgcggcggg ggccggtggc ctgtacggca gcgggcggtg cgggggcgga
     6661 cggcgtcgcc ggtgcggccg gggtctgcgc gaggacgcgg gcttgtgcgg gcgttgccgg
     6721 cggcggtcgt cgtcaccgcg atcgtgctgc ccctgtccgc cgcggcgcgg cccgtcgtgc
     6781 ccgccccgcc gccggcgcgg ctcgcaccgg cgaccgcggc cacgctcgcc gggacgtacg
     6841 cggcccaccg gggcaacgcc gagaaggcgt cccggatggc cgcggcgcac ggcgacgacc
     6901 ggagggccgc cgcggaccgt gccctcgccg cgccgggcag acagctgctg gcgttcgacg
     6961 ggcgcgggtc cgggcgggcc gtcgaggtgc tcggcgacct ggcccgcgcc gaccgggtcg
     7021 ccgtgctcgt gccgggctcg gacacctccc tggacaccta cggccggttc cgcgcgacgg
     7081 ccacggccct gtacgaccgg ctggtccacg aggccccgcc cggcaccggc gtcgcggtcg
     7141 tcgcctggct cgggtacgag actccgggca cggtcggcac ggccgtcctg acaccggacc
     7201 gggccgacga ggccgcgccg gaactgcgcg agctgatacg gcagttgccg ctcatcacag
     7261 gaccgggcag ccacgtggcg ctgctgtgcc actcctacgg ttccgtggtg tgcgcccgcg
     7321 ccgcctccgg accggccgtg gacgacatcg tcctgatcgg cagccccggc accggcgcga
     7381 aggacgtgac cgcgctgcgc acgaccgcgc gtgtgtgggc ggcccggggc gcggacgact
     7441 ggatcgccga cgttccgcac gcccgtgccg aactgctcgg cgtgaccgtc gggttcggca
     7501 ccgacccggt gtcgccgcag ttcggcgccc gcgtcttcgc ggccggcgac ggcggccacg
     7561 gcgactactt ccggccgggt tcggtgtccc tggcgaacct ggcccggatc gtgctcggtg
     7621 agcaggcgga ggtgtcccgt gcgtgacggc atccggcaca tggccgcccg gatcgactcc
     7681 gccaccccgg cggaccggga ccgggccgtg gacgcgctgc gggcgtgcgc catcctcggc
     7741 gtggtgctcg gccactggct ggtgaccgcc ctggtctccg agggcggcac cctgcgcacg
     7801 gacagccccc tgcgcgccct gccctggctg gccccggtct cctgggtctt ccagacgctc
     7861 gccgtgttct tcctggtcgg cgggcacacc gcgaccgccg gtctggcctc ggcccgggcc
     7921 cgcggggtgc cgtaccggag atggctggcg gcccggctgg cgcggctgtg gcggccggcc
     7981 gcggcgatgc tcgcgctgtg gacggtggtg gcggcgctgc tgctcgcgac gggcgcggag
     8041 ttcacgaccg tccgcacact ggtgaagctg gcgctgtccc cgctgtggtt cctgctggtc
     8101 ttcgccgggc tgaccgcggc gaccccgctg ctgacccggc tcagcccgct gtggccgctc
     8161 gccgtcgtcc tccacgtgga cctggtgcgc ttcggcctcg gtggcccgtc ctggctcggc
     8221 tgggtgaacg tggcggcggg ctggctggtg ccctacaccc tcggcgcggc ctggacccgg
     8281 ggcgagctgg agggccgccg cgccgggtgg gcgctgctgg ccggcggggc ggcggcgacg
     8341 gcggcactcg tcgcgggggc cgggtatccg gcgtcgatgg tcggggtgcc gggcgcggag
     8401 gtgtccaacc tgaacccgcc cacgctggcc gcggtcgcct tcggcctggc ccagtgcggc
     8461 ggcgccctgc tgctgcgcgg gccgctgcgg cgggcgatgc ggcggcggcc ggtggcctgg
     8521 gcgggggtgg ccgtggccaa cctgtcggcg atgacggtgt tcctgtggca ccagacggcg
     8581 ctgatggcgg cgacggccgc cgcgctgccc gccggcccgc tgcccggcct gcacacccgc
     8641 cccgacgacc tgcgctgggt cgccgcccgc ctcgtctggc tgccgctgtt cgcgctgggg
     8701 ctcgtggtgt gccggtcggc gttccacggc ttcgagagcc gacggggccg tacggagcgg
     8761 cgggggtcca cgggcagcga ctcccgggtg gtgcgggcac ggcggccggc gggggcggcg
     8821 gcgggcggca ggccggagcc ggcgggcgac ggacccgaac cggtgggcaa ggggccggcg
     8881 acggccggtg aggaggtggg gcggcgtgcg tagggtggtg ccgatgaacg gggtggggga
     8941 gcggctggcc cgcgaagcgc gggtgctgtg gggcgagctg tgggcggccg ggcgggcgcc
     9001 gttgccgccg tcggtgtggc tgcgctggct gccgcacggg ctggtgtgcc tggtggcgtt
     9061 cggtgtcgtg atcgccaacg gggaccaggt ggggcagggc taccggcagg gcacggagta
     9121 cgcgctgctg tgctcgctgg cgctcggcgc gggcgtggtg ctggcgctgt ggtggccggt
     9181 gcagggctgg tggctgtcga cggcggtgaa cgtggtgacc gcggtgggcg cgcggtcgca
     9241 gctgatctcg ggtcaggccg agcccgattc gccgtggccg tggaccccgc cgggcatcgt
     9301 ggcggaggcc atggtgctgc tgctgctggc actgcggatg cccacccggg tctccgtcaa
     9361 gatcctgggg ctgaccgcgc tggtgacggc cgtcgtgcag ggctggctcg gcgggtcgaa
     9421 ctacgcgccc accggcacct tcgccgtcgc cctgttcgcc ggtgtcgtcc tgctcggcac
     9481 cgccctgcgc ggccggcgcg aggcccgcca ccagctcgtc gagcaggccg gcatcaccgc
     9541 cgaggagcgg gccaggcggg cgctgctgga ggagcgcagc aggatcgccc gggagctgca
     9601 cgacgtggtc gcgcaccaca tgtcggtgat ctccatccag gcgcaggtcg ccccgcacct
     9661 ggtggagaac ccgtcgcagg agctgaagga gaacctcgcc ggcatccgca acaacgcgct
     9721 ggaagccctc acggaactgc gccgggtgct cggcgtcctg cgctccgaac acccggagga
     9781 cgcgtccggt gtggccgccc ccggcaccgg gcccgcgccg gacgccccgc agccgacgct
     9841 cgaccggctc gacgccctcc tggacaacgc gcgctcggcg gggctcacca tcgccaccgg
     9901 catccagggc gaacggcggc cgtatccaca ggccgtggag ctgtcggcgt accggatcgt
     9961 gcaggaggcg ctgagcaacg cgatacgcca cgcgccgggc tccgccgtaa aggtggagat
    10021 cgcgcacctt cccgacggac tgttcctcgg ggtgaccaac tcccgcccca cgcggcccgc
    10081 ggcgccgtcc ccgggcgtgg ggcacggcct gctcggcatg cgggagcgcg ccgcgatgct
    10141 cggcggccat gtgacggcgg tgcccagtct gcacggcggg ttcatggtca cggcgttcct
    10201 gccacgcgac ggccgccgcc gcgcaccggc cacgccaccg gcaccggaca cccgcctgcc
    10261 cgcggcagac ctgatgttcc cgacctcccc gacctccccg acctcccccg actccccgac
    10321 cggagaagag accccatgac cagcggcacc atccgggtac tgatcgccga cgaccagcag
    10381 atggtccgcc agggcttcac cgtgctgctc aacacccagc cggacatcga ggtgatcggg
    10441 caggcggtgg acggcctgga cgccgtggcg cgggtcgcgg acctcgcgcc ggacgtcgtc
    10501 ctgatggaca tccgcatgcc ggagctgggc ggcatcgagg cgacccggcg catcaagggc
    10561 gccacccccg agatcaaggt gctggtgctg acgaccttcg acctcgacga gtacgtgtac
    10621 gacgcgctgc gcgccggagc gtccggcttc ctgctcaagg acgcctctgc cgagcaactg
    10681 gccgacgcgg tacgagtggt ggcggccggg gacgcgctgc tcgcgcccgg cgtcacacgg
    10741 cggctgatcg cggagttcgc ccgcctggac ggcaccccgc gtcccccgct gaaggagcgc
    10801 gtcggtgatc tgaccgagcg ggagacggag gtgctcacgc tgatcgcgca gggcctgtcc
    10861 aacgcggaga tcgcccagcg gctggtcgtc gccgagcaga cggtgaagac ccacgtcggc
    10921 cgcatcctgg tcaagctggg cctgcgggac cggacccagg cggcggtgtt cgcgtacgag
    10981 tcggggctgg tgagaccggc gggatactga gcgagccggg ctgcggcggg cggccggacc
    11041 agcgcagggc aggccggcgc aggccaggcc aggccaggcc aggccagcgc agggcaggcc
    11101 ggcgcaggcc agggctggtc aggccagggc gggccaggcc agggtggggc aggccaaggc
    11161 agccagggca gggccgcgcc cgccggacgg gttccccgag gggtgtccgg cgggcgcggg
    11221 gtcagtgctg ccgggtgtcc gcgccctccg ccaccaccac cgccgtcgcg atgcccgcgt
    11281 cgtggctgag ggagacatgc caggtggtga tgcccaggcg ggtggcgtgg gcgctggccg
    11341 ggccgtgggt gtggacggcc gggcggcccg aggcgcactg ggtgacctcg atgtcccgcc
    11401 agcccacccc gagcgggccg ccgagcgcct tcaggaccgc ctccttggtg gcgaagcggg
    11461 ccgcgaggga ggcgggggcc cggtccgtgc cggcggggga gcggcgttcg gcgggggtga
    11521 agaggcggtc ggccagggcc ggggtgcggc ccaggctgcg ggagaggcgg gccacgtcga
    11581 ccacgtcggc gccgaccccg cggatcaccg cctgcccccg acgcccgcga ggcccagggt
    11641 gtccagcacc cggcgggtca cctcgtccgc cgtgccctcg gcgtcgaccg tgcgcagcag
    11701 gccggcgtcg gcgtagaacc gggcgacggg cgcggtctgt tcggcgtgga ccgcgagccg
    11761 gtcccgtacg gtggcgggcc ggtcgtcgct gcgctggtac agctcgccgc cgcactggtc
    11821 gcacaggccg cgcacgatcg gcggcgcggt gcgcaggtgg aagatgtggc cgctgtcgcg
    11881 caggcacacc tgccggccgc cgatccgccg gatcacctcc tcctcgtcca cgacgaggtc
    11941 gagcgccgcg gtcagggccg taccggtctc ggcgaggatc gtctccagtg ccttcgcctg
    12001 gacggcgctg cgcgggtagc cgtcgaggac gtacccgtcg gcggcccggc cggagtgcag
    12061 gcggccgcgg acgatcgccg tgatgagggc gtccgggacg aggcggccgg agtcgatgaa
    12121 gtccgccgcg cggcggccca ggaccgtgcc ggccgccacc tgttcgcgca gcaggtcacc
    12181 cgtcgacaga tgcggtacgc cgaagcgttc cgccagccgt ccggcctggg tgcccttgcc
    12241 cgcgcccggc gggcccagca ggacgaggcg catcagacga cctcctccgc cggccggggc
    12301 gccccgcgcc gcagcgccgt cacgatcagc gccgagcaga tcagcagtcc gccggtcagc
    12361 cacaggccgg gccgtaccga acccgtccag tccttcagcc agccggtgaa gtagggggcc
    12421 gcgaagccgc cgaggctgcc gatggtgttg accagcgcga taccggccgc ggcgccctcc
    12481 ttgccgagca tcgccgtggg cagcgcccag aacaccggga tcgccgacag cacaccgatc
    12541 gcgcagacgc tgatcacgac catcgtggcg agcgggccgt gcatgtagag ggcgacgggg
    12601 acggtcacgc cggccagtac ggcgggcagt gccaccgtcc aggccgcgcc cggggtgcgt
    12661 tgcgcccgcc ggccccacac cagcatggcc accgcgccca gcgcgtacgg cacggcgttg
    12721 atcaggccgc gctcgacgat ggagaactcg cggccgttgt cgccctggaa cccggcgatg
    12781 atcgtcggga ggaagaagct gagcgcgtac aggccgtaga cgatgccgaa gtaggcgaag
    12841 ccgagggcga aggtgcgcgg ggtgaaccag ccggcgccgc gtcgcttgac cgacggctcc
    12901 ggctcgtcct ccgcaacccg ggccagcagc cagtcccgtt cggcctcggt cagccagcgc
    12961 gcctcgcgcg ggccgtcggg cagcgcccgc cacaccacga ccgccagcag cagcgccggg
    13021 acgccctcca gcaggaacat cgcccgccag ccgggcagtc cggccagccc gtcggcgtac
    13081 tggacgatca ggccggacag cggggcgccc agcgcggtcg acaggggcag cgccacgaag
    13141 aagaccgcca tcaggcgggt gcggacgttc ttcggcagcc acagcgtcag gtagaagacg
    13201 atgccgggca ggcagcccgc ctccgcgacg ccgagcagca gccgggccgt ctggagctgg
    13261 cccgcgctcg tcacgaacgc ggtgagcgtg gccaccacgc cccaggagac gaggatgcgc
    13321 accagccagg cgcgggcgcc gaagcggcgc agcgccatgt tgctggggac ctccaccacc
    13381 gagtagccga ggaagaagat cccggaggcg aggccgaacg cggacgacga caggttcagg
    13441 gcctcgttca tgccgttcgg cgcggcgaag gcgatgttgc tgcggtccag gtagctgacc
    13501 aggtacagca ggccgagcag gggcagcaga cggcgggcga ccttggcgta gagccggtcg
    13561 gcggcgatcg tctggcccgc ccgggccgcc tcggcggccc gggtcgaggt caggggagtg
    13621 gtcacgaggc gtcctccagg aggtgtgcca gatcgcccag ggcgtccttg atctgcgcgt
    13681 gcgtgatgtc gcccaggcgc agcaccttga acggcagttc ggccgcggtg acgatggtgg
    13741 aggaggcggt ggtgccctgc ttctcgccgc ggatcaccat gtccacggag gcgcctatct
    13801 gctggacggc caggtccagg tcgaccagca cgccgtcggc ctgaccggac aggttggccg
    13861 aggtcatcgc gaccgggtgg ccggtgaact cgatcaggcg ctggatggtc gggttggaca
    13921 ggcagcccag ggcgacggtc gggccgccgc acaccaggtg gtccgggatg cggtggttgc
    13981 ggggcaggac gatgttgaac gggccgggcc agaaggcgtc cgtcagccgg cgcacggcct
    14041 cccgcagctc ggcggggacc tcggtgtact cctcccactc ctgcgggtgc cgcacgaaca
    14101 gggtcagcgg cgaggtcggc gggcggcgct tgatggcgaa cgcccgctcc acggcggccc
    14161 ggttccacgg gtccagggtc agcgccaggt tggtgtccga gggcgccacc acgaccccgc
    14221 cggtgcggac cagggtgccc gcggtgcgca ggttctcgtc ggtgggggcg gcgacattgg
    14281 cgtacgtgtc gacagtcatg tgtctcactt ccggtgttgt tcgaagaagg ctgtgggggg
    14341 cgttacttgc tgagctgggt cgacgggtcg accagggtga aggtgcgcgg cacctccacc
    14401 gcgcgcagcc ggccgcggca ccagcgccgc agctcggcgg cgtcgacgcc ggctccgccg
    14461 gggcggggca ggatctgcgc ggccaggccc ttgtcgccgt cggcggcgac gcgggcggcg
    14521 ctcacctcgg ggtggtcggc gaggacgcgt tcgacgaggc cgaggaagac cttctcgccg
    14581 gccaccgagg tgacccggcg cgcgcggccg accaactggt aggtgccgtc gggcagttcc
    14641 tcgcagatgt cgccggtggg cacctcgtcc ccggcgtacg gcacgtacgc gccgtcggtg
    14701 tagccgcccg cctgggcggt gggggtgcgg acgaccagct cgccgtccgg gccgagccgc
    14761 cagctcaccc cggccagcgg ccggccgagc ccgccgtcgt gcgcggtgcc gcccggcgtg
    14821 tgggtggcga cgcgcggtcc tgcctccgtc agcccgtagg tcgtacggac gtcgggcacg
    14881 ccgcgggcgc gcagctcggt cagcgcggtc cggccgagcc ggtcgccgcc gacggtgacc
    14941 tggcgcagcg acgccgggaa gcgctcgccg ctgtccagca cccgcatcag caggtgcggg
    15001 gtgagcgcgg tgtgcgtggc gccgaagccg cggcccgcgt cgaaccagtt cgcggtggcg
    15061 aacggcggct cgatcagggc gagtccggcg ccggcggcga ggacgccgag gactccgcag
    15121 acgaacgcgg acgagaagta catcgactgc gacagcagat agcggtcgcc ggggccgagc
    15181 ccgccgacgc tgtcccagtg catgccggcg ttgcgcagca gccgggagcg gcggtgcacg
    15241 acggccttcg ggagtccggt gctgccggag gtggccagca ccagcgacgg ctcgtcgtac
    15301 ggcggcgcgc ccgtgcccgg ctccccgtcc agccgcagca gtacggtgcc cgcgtcccgc
    15361 gcgaggggtc cgccgccgcg cgccgcccag gtccgggcga cggccggggt gagccggccg
    15421 gcgacggcgc cggtggccgc cgcgagcagc cggtagctgt ccggggcgag cgcgtccgac
    15481 agcagcaccg gcaccagccc ggcctcccag gcggcggcga cgtccagcag ggtggtgagc
    15541 cggctgccgg tgccgaccag cacccggtcg cccggcgcga agccgtgccc ggcccactgc
    15601 tcggcgcgct ccgcgacgcc cgccaccagc gcggccgcgt ccagcacccg caccccgcgg
    15661 ggcgtgtact cggtgacgga ggcggcggga tggacccagc cggcgcccgc ctcggacgcc
    15721 ccaccgggag caacaccgcc ggaggcgaca ccgccgggag cagcacccgc cccggccggc
    15781 cccccgagga gagcctgtgc ggtcccgctc atcgcacccc cgccgtcctg gcgtccgcca
    15841 gcagcggggc gacccggtgg gccgccgcga agtcctccgc ggccggggcg ccgcccgggc
    15901 cgtccgtgcc gcgcggcgcg tacaggtcgg ccgggtccag cgccaccacg tgctgctcgg
    15961 agacggacac cgcgctgtcc acgtgctcga cggcggcgag gacggccagg ccctccccgg
    16021 agcgcccggt ggcgtccggc agccacgtga cgtggccgac gtagcccgtg cggatcgcgc
    16081 cggagccgag ccgcagcgcg gccaggaaca gcgccccgtc gagggtggcg cgctgcccgg
    16141 cgagcaccac cgacggtccg cgggcggcga gttcgcgggc ggtgctctgg gcgacgatgt
    16201 tgtagccggc gacggagaac gtcgacggcg agcgccgccc ggccgcgagc gccccggcga
    16261 aggcgcgcac cgagcgctgg ttgccgcgcc gcgtgctcac gaacaccccg cgggagaacg
    16321 ggtcgtcgtc cccggccggg gacgcggtgg tcagttcgcg ggcggcgagc gcgccgagca
    16381 gcgacgccgg gtcctgcttg ccgcgcacgt cctgcgcggc gacctcggtg acgagggctt
    16441 cgggcacatg gtcctgggac aggtccgcgc ggaagccggg ggtggcgagg accaccgccg
    16501 cacgcagccg gacggctccg cgcaggccgt ggaagaacac ggtcgtcatg tcacctcctg
    16561 ggtgcggacg gtggccgagg agtggacccg gccctggacg gacagtgagg cgcgcacggt
    16621 ggacagccgg ccggagcgca gcagccgcgc ctccagcacg gccccggccg gggcgacggc
    16681 ctcgtcggtg atctccagct cgtcgatccg ggccgggacg cagcggttcg cgccgcgcgc
    16741 ccgggccgcg agccggcagg cgatctggtg catcgcctcg acggcgatca gcggcccggc
    16801 gccggtcaga tccccggcgg gcaggacgag ttcggcgcgc gcggcgtccc cgtccacctc
    16861 cagcggcccg cacaggccga ggaaccagcc ggtggcgggg gcgtacggct cagccatggc
    16921 cggcgtcccc cggccaggtg cccatcatgt ggtagccggc gtcgacgtac accgtctcgc
    16981 cggtcgtccc ggacgacagg tcgctgagca ggtacagcgc ggtgcccgcc acgtcctcgg
    17041 tggtgatggc gcggccgagc gggctgcgtc cggcgcgctg ggcgagggag gccgcgaagt
    17101 tgggcagccc gaaggtggcc agggtgcgca ccggcccggc ggacagcacg ttgacgcggg
    17161 tgccggacgg gccgagttcg gcggccaggt agcgggcggc ggactccagc gcggccttgg
    17221 ccacgccgag cacgttgtag ccgtggcaga cgcgttcggc gcccaggtag gacagggtca
    17281 gcacgctgga gttcggggtg aggtacggcc gtaccgcgcc cgcgagcccg atcagcgagt
    17341 agacgctgga ctccatcgcg tgggtgaagc cggaccggct ggtgctcgcc aggccgccgg
    17401 ccagctcgtc cttgtcggcg tgggcgacgg cgtgcacgac gaagtcgatg ccgccgtgcc
    17461 gctcggcgaa ctcggcgcac acccgctcca gcgcgccctc ctccagcacg tcgcagtgcc
    17521 cgaggtacgg cgcctcggcg ccgtcggcga ccagccgggg cgtggcccgc tgcagccact
    17581 gcccggcgga ggacgcccgg taggtgaagc ccagttcggc gccctcggcg gccaggcggc
    17641 gggcgatgcc ccaggcgatg gagcgctggt tgaccacgcc gaggaccagg ccccggcggc
    17701 cggccagcag cccggtgcgg gcgggggcct ccgtggcggg ggcgagggtg ccggtggaca
    17761 tgtgcggtcc cttctcaacg gtcgtcgtgg tactcacagc tgggcacctc cggccaccgg
    17821 cagcaccgcg ccgaccagtt ccgggttgcg ggtcaccagc gcggccacca cctgggcgac
    17881 atcgcgcggg ttggtgaacc ggcgcagcgg gatctcctgg aggtacttct tgcggtcctt
    17941 gccgtcgagc atcaccttgg tcaggtcggt ctcgacgaag ccgggttcga cgacgttggc
    18001 gaacacgttg aaccgggcgc cctccagcgc gatgttggcg gcgtaccggg tcagggccgc
    18061 cttgctgacg ccgtacatgg cgttgccgac gcgggcgttc cggcgggcct gggaggagat
    18121 gaagacgacg tcgccgcggc ggtgccggag catgtgcggc agtgcggcgt gggtgaaggt
    18181 gacggcgctg cccaggttgg tgtcgaggag ctgctccagc tccggccagg tgacctggtt
    18241 gaccagccgg tccacggtga gcccctggtt gttcaccagg gcctggagcc ggccggtggc
    18301 ggcgacgcgg tccatgaacg cgcggacctg ttcggcgtcg cggccgtcga cctgggagcc
    18361 gcgggccagt ccgccggtgg cctcggtcag ttcgtccgcg gcccgctttg agctgaggta
    18421 cgtgaactcg acgtcgtagc cctcctgggt gagcctcctc accacggccc ggccgatgcc
    18481 ccgggccccg ccggtcacca ccgcgaccgg ccgcccgccg ggctcggaac cctcagtcgt
    18541 ctgcacgctg tcggtcatcg gtgaccacct cccctcgtac ggcgacgacc tcccggccgt
    18601 cctcttcttc gatcagtgcg gtgcaggtga cggcgccggc gtcgtcggcg gtcgccgtga
    18661 ggcggacccg ggcgggcggc accagcgggc gcgcgaaccg cacgtcccgc aggccgcgcg
    18721 cggccgggtc caggcggcgg gccaggccga gcagcaggtg cgcggcggcc gagccgggca
    18781 gcaccgggtt gcccgggaag tgctcggcga agacgggcca gccggggtcg aggtcgagca
    18841 cggcggtcac cgtgccgtcg gtgtgccgga cgtccggggc gaccggaatg cccagcaggt
    18901 tcccgctcat gcggccaccg ccgcttcccg ccgcgccccg cgccgggccg tcagccgggc
    18961 caactgccct gtgacaaaac gggcgtagga gtccgcgtcc acccgggggc gggccgcggc
    19021 cggtacgtgc gcgtcgagca cggcgtggtc gaagcggaag ccgcagctca tgaacgccac
    19081 gttgtcggcg ttgaccgagg cgtacgcccg gtccagtgcc gtcgcgggcg gcccgagccg
    19141 cagcacctcc gcgcccagtg ccgcgttgac ggcgtccgcc gcggcggcgt tcgtcagggt
    19201 ctggtcgccc aggtggtagt aggcggccac ctcggcgccc cgcgcggccc ggtccgccag
    19261 cgcggcgcag ctcgcggcga gctggtcgac gtgggcgagc ggcggcgcgt tgccgggctc
    19321 ggcgtcgatc gtgagcgccg cgcggcgggc gacgaccttg gcgagcatct cgacgagcgt
    19381 gtagtacccg gcgcggttgt cctgcacggc cgcgtgcccg tcgggcccga tgaccgagcc
    19441 gagccgcagc atcgacacgg gcgcgccggt gtgcgcgcga aggttgtcca gcatgtgctc
    19501 ggcgagcagc ttcgacagca cgtacgggtt gaccgcgtcc ggccgccaca ccggcgcctc
    19561 ggggacggtc tcccgccgcg cgggcgcgcc cggtccggtg acgccgacgg tggagatgtg
    19621 gaagaaccgc tcgtcgggcg cgcacagctc cagcagccgc agtggtacgg ccgtgttggc
    19681 ggcgaccgtc gcggccagct tgtcctggtc gtacgacagg gacgcgccga cgttccacac
    19741 ctgcgcgacg gagtccagcc cggccccgcg cagcgcggcg ggggtcagcc cgtccagcgg
    19801 cagcgcggtg acccggtcga gcagaccgtc ccgcccctcc gtgccggccg cctccagcac
    19861 ccgtccgatc cggcggcgca gccgctcggt gtccggtgcc ccggcggtga gcagcagcac
    19921 ccggtcgaag gcgggcagca gtgcggcggt cagtgcggtg ccgaccaggc cgccggcgcc
    19981 ggtgaccacg aggttccggc tcatgccgcg cccccggcgg tcaggacgac gcaggagttc
    20041 gcgccgccga agccgtaggt gacgctcacg cccagggcgc ggtccgcgtc cagcggcagc
    20101 ggcgcctcgc cggtcgcgac aggggcgccg gcccagcggt cgtgcggggt gcgcaggccc
    20161 gcggtcggcg gggcgacccg ctcgcgcagc gcgtacgccg tgagcagcgc ctccaccgcg
    20221 ccggtcgcgc ccagcgagtg gccgagggcg cccttggtgc cggagacggc gacgtcccgc
    20281 tcggggaaga ccgccgcgta caccgcggcc tccagcgcgt cgttgacggg cgtgccggag
    20341 ccgtgcccgt tgaggtgggc gacgtcggcc ggggtcgcgc cggccatcgc gagcgccgcg
    20401 cgcagcatcc gcgccgcgcc ctcgccggac aggtccgggg aggtcagcgc gtcgatgtcg
    20461 gtgctggcgg cccagccgcg caactcggcg aagggcactc cgggcagccg gtcggcggcg
    20521 gtgaggacga gcgcgcaggc gccctcggcg agggtggtgc cgtcgccgtc ggcgtcgtag
    20581 gggcggcagc ggtccgggga catggtcttc agcccggagt ggcccgcgta cttgccgggc
    20641 tccagggagt ccacgccgac cgcgaggacg accggggcga tcccggaggc gaccaggtcg
    20701 gcgccgtagc cgaccgcgtc ggtgccggag gagcaggccg aggagagcac cacgaccggg
    20761 ccggtcaggc cgagccggcc cgcgacctcg tcccagaagt ggtcgagttc cacgtcgggc
    20821 ccggtctgct cgaagatgtc gccgagactg atcccgacgg tcacccacgc ctcggcgagt
    20881 tcccggcggt ccacgccggc cgcctccgcc tgccgcagcg cctcggtcag cgcggcctcg
    20941 gccagcgccg cgaggcgcgg cccgccggtg aggccggcca gcccggccac ctcaccgacg
    21001 gtgccgctgc ggcccgtgct gcccgcctcg aacaggctga gcgggccgag cccgctggcc
    21061 ccggcccgca ccgacgccca ggtggcgtcg gcggaaccgg cgaggcaggt ggtcgcgccg
    21121 gccgcggcca cggcgacgcg gacgggggtg tcgccgctca tgcggcccgc tccgcggtct
    21181 tcggcgcggg gagctgccgg gcgaaggcct ccggcaccgg cagcagccgg tagggctcct
    21241 tctgcacgaa gacgaggttc agctcggcgc gggccagcag cttgccgcgg gcctcggcgc
    21301 ggaagtgcag ctggagcgcg cggcccaggt tctcggcacg ggtcacggac acctgcacgg
    21361 tgtcgttgcg cagcgccgag ttgctgtagg aggcgcggac gcgggcgacg cggatctcca
    21421 cgccctcgcc gaagaagccg ggcggcgagc tgtagcggcc gaggaactcc ttcagcgcgt
    21481 tgctgtacca cttcaggtag ttggagaagt gcacgacctc gaactcgtcc acttcggcgt
    21541 cccggacggg atgctccagg ctgaggatca tcaggtttcc ccccttgtcg tgtctgcgtg
    21601 tcgtggcgtg gtcagccggc gagcttgcgg ccgaccaggg cgacgatgcg gccgacggtg
    21661 gcgaagttgt ccgggacgaa ctcgccgtcg gtgacggata tgccgtactc gtcctccagg
    21721 tgggcgagca gctcggcgaa gccgagggag tcgacgccga cgtcggtgcc gaggagcatg
    21781 tcgtcggtga tctcggcggg ctccatgtcg atgaacagcg cgtccacgat gaactgcttc
    21841 aggtgggcgg cgacggcgtc ggcggcgaag gtctcgttgg cggtgacggt catgacgtac
    21901 tccttgcgaa acggtgggtg ggaggccggg cggcgggcgg tccgccgccc ggctgaggaa
    21961 ggtgtggcga gggtcagtcc tcgagcgtgg ccagcgcggc cttggcgatc ttgatgtcgt
    22021 cgctccagtg gccgccgctg acgccgatgc cgccgacgac ctggccgtcc acgacgatcg
    22081 gcaggccgcc gccgaagacg atgaggcggc ggatgccggt gggggcgccc atggcgagcg
    22141 gctggtcgtc cttgatgaac tcgtgccact ggtcggtcgg caggccgaag ccggccgccg
    22201 tgtacgcctt gtcctgggcg atctccaggg tgagcagggc ggcgccgtcc atccgggcca
    22261 gggcgttgag gtggccggac tcgtcgacga cggcgacggt ggagggctgg ccgagctcgg
    22321 cggcggcctt gagggccgcg tcgacgagct gccgggcgag ctcgttgctg agggcggcac
    22381 gctggcggac ctgggcagac atggtcaact ccttgtgaat cacgaacaga tgggtggggg
    22441 tggtggtctc agaccgcgac cggcgccttc gcgggggtgt ccgcggcggc ggtgcggggc
    22501 agggcgacga cggccgcggc ggcgagcgcc aggtagccga cgacgacccc gaggagcagc
    22561 tgcgggaagc cgacccggtc gagcagcagc ccggcgagca ggatcagcag cgtgttgacc
    22621 gcggcgaacc gggcctcgtt ggcgcgcagc gcggcggcct tctcggcggc gggccggtcg
    22681 gccagcagct ccccgatggc gccgaccgcg accggccgca ccgcgcccac acccgcgccg
    22741 agcgcgaggg tggcgacggc ggcaccggcg gtgttcggct gccacagcag gatcagcagg
    22801 ccggccccgg cgagcgaggc gctggcggtg gcggtggcgc gggcgccgaa ccggtccacg
    22861 gccgcgcggc cgtaccgggc ggtgaagtag ccgctcagcg tgtacgagcc gaggaccagc
    22921 ccgaacaccg gcagcgacac atgcagccgc aggtagagca gatacggcag gaagccgatg
    22981 aacagcgcca gcacgaaggc ccgtacgacg gtgtagtacg cgctccagcg cagcacggcg
    23041 gcgtacgcgg ggcccttggc ccgctgggcc ggcgtgtcct tcggcgcggt ggccgtcggc
    23101 ttgaccgccg gttcgagccc ccgcccgacc agcggcgcgg tcagcgcggc cagcgcggac
    23161 atcgccgccg acaggtagaa cggcgcggtg tgcgaggcct ggtagaggat cgcgccgagc
    23221 acaccggcga cgagcgcggc ggcgaaggtc agcgagccgc tgcggccctc ccaggcgcgg
    23281 gcgtcggccc cgtcgcggcg gcacacctcg gcgagcagcg ccgagtcggt gccgctggcc
    23341 agggagaagc cgagcgcggc gatgatctgg ccggcgatcg ccacgggcag cccgcccggc
    23401 agggcgagca gcaccagacc ggccgccttc agccactcgc cggtggcgac ggcaccggtg
    23461 aggctcagcc gggcggcgag cggcttggtg acgggtccgg cgagggccag ggcggcgccg
    23521 tacacggcga gcgtcagctc cactgtgggc agcgacaggc cgcggtcgta gaggaagacg
    23581 aacaggatcg tgaggtggaa gtagctgcgg gacaggaccc ggtagccggt gaacagacgt
    23641 ggggcggaga gcatcgcacc tcccggggcg acggtgacgg acggaccgtc aggcggcggt
    23701 gaccgtcggc ttgaaggagg ggcgccggtc ctcgtacgcc cggatcctgt cggcgtgccg
    23761 cagggtggcg tcgatctcgt cgaggccctc catcagccgc atgcggtggt aggggtccag
    23821 ctcgaacggc acggtcagct caccggcccg cacctccagc gcggccaggt cgacggtgac
    23881 cggctcctcg gggaactcct cggcgcgccg ccacagttcg gcgatgacct cgtcggggag
    23941 ctggatggtg agcagcccgt tcttcagcga gttgccgcgg aagatgtccg cgaagcgggg
    24001 cgagagcacg acccggaagc cgtggtcgag cagcgcccac acggcgtgct cgcgcgagga
    24061 tccggtgccg aactcggggc ccgcgaccag cacggtggcg ccctcgtggc gcggctggtt
    24121 gagcacgaac tccgggtcgg tgcgccacac ggcgaacagg ccgtcggcgt agccggtgcg
    24181 ggtgagccgc ttcaggaagc ggaccgggat gagctggtcg gtgtcgacgt tgctgcggcg
    24241 cagcggcagc atgcggccgg tgtgggagac gaagggttcc atggtcagac ctcggcgaag
    24301 acgggctcgg gcagggactc gggcgaggcg agggccccgg cgacggcggt cgcggcggcc
    24361 accgcgggcg acaccaggtg ggtgtgggac ccggcgccct ggcgtccctc gaagttgcgg
    24421 ttggaggtgg acgcggcgcg ctgcccgggc tgcaggaagt cggggttcat ggccatgcac
    24481 atcgagcagc ccgcgttgcg ccactcggcg ccggcctcgc tgaacacccg gtccaggccc
    24541 tccgcctcgg cggccgcctt gacccggtcg gagcccggta cgacgagcat ccgcacccgg
    24601 gggtcgacgc gccggccgcg cagcacctcg gccgccgccc gcaggtcctc gatccggccg
    24661 ttggtgcacg agccgaggaa gacggcgtcg acggggatgc cggccagcgg ggtgcccggg
    24721 gtgagtccct ggtaggcgag ggcccgctcg caggcggccc gctgcgcggg gtcggcgaag
    24781 gactcggggg ccggcacgag cgagtcgagc ggggcgacct ggctggggtt ggtgccccag
    24841 ctgacgtacg gcgtcagcgt gtcgaggtcg acgtcgacct ccttgtcgaa gacggcgtcc
    24901 tcgtcggtgc gcagcgtgcg ccagtactcg acggccgcgt cccagtccgc gccgcgcggg
    24961 gcgtgcttgc ggcccttgag gtaggcgaac gtggtgtcgt cgggggcgat catcccggcg
    25021 cgggcgcccg cctcgatgga catgttgcag atggtcatcc gcgcttccat cgacagcccg
    25081 gcgatcacct cgccgcggta ctcgatgacg tggccctgcc cgccgccggt gccgatcttc
    25141 ccgatgaccg cgaggatgat gtccttcgcg gtgaccccgg gccggggcgt gccgcgcagg
    25201 ttcacggcca tcgtgcggaa cggccgcagg cgcagcgtct gcgtggcgag cacgtgctcc
    25261 acctcgctgg tgccgatacc gaaggcgagc gccccgaagg caccgtgcgt ggaggtgtgg
    25321 gaatccccgc acacaatggt cgtacccggc tggctcaatc ccgtttccgg accgatcaca
    25381 tggacaattc cctgtcccgg atcgcccagc ggataaagcg tgaccccgaa tttctcactg
    25441 ttctttcgaa ttgcctcgac ctgcgcccgg gaggtcgggt cggcgatcgg cagaccgatg
    25501 tcctgggtgg gcgtgttgtg gtcctcggtc gccagggtga ggtccgggcg ggccaccttc
    25561 ctgccgcgca gctccaggcc gtcgaaggcc tgcgggctgg tgacctcgtg cagcagatgc
    25621 aggtcgatgt agaggatgtc gggctcgccc tcggcccggt ggaccagatg cgcgtcccag
    25681 accttctcgg ctagcgtctg ccccggcacg tcgactcctg tctcgtgggt gttgttccga
    25741 cgagtagaac tgaaacagga ggggaatgac gtcctcaata gaagtgcccc gcagggcaca
    25801 tgggcgtacc actaaagtga cacggcccca cggaatgcca tattcctcgt gcgatttccg
    25861 cacctgccga tctagattcg ctgccgtgag catcgtcgcc gaacgtcatc gaccccttac
    25921 cgaccgccgc ctcgggcacc ggctgctgct gtgcgtccag gaggcgcggc cgctggtgca
    25981 ggccgccttc gtcctgcggt tcgcgctggg cgcgctgtgc acgctgggca gcggccgggc
    26041 gccgggctta acggtgctgg ccggtgccgc cgcctggtgg gcggccacca cctgcgcgta
    26101 cctcttcaac ggcctgatgg acctgcccga ggaccgcgcc aacggctcct cccgtccgct
    26161 ggccggcggc cgcctcgacg tacgcaccgc ccgcgccgga gtggtggccc tcgccgtcac
    26221 cgcgctcgcg ctcagcctgt tcgcgccgcg caccaccggc tgcgtcctgg tcttcctcgt
    26281 cctcggctac ctgtactcgg cgccccgcgg cgcggccaag ctgcgcgcct ggtccgccag
    26341 ttgtgtcacc accgccgcca ccttcgccac ctacctgggc ggtgccctct ccacgggccg
    26401 cacgcccagc gccaccgccc tgctgttcgg cgccgtcatg tcgctgtggg tggggctgat
    26461 cggcgccgtc gccaaggacc tcggctccac cggcggcgac gcgctggccg gccgccgcac
    26521 cctcgccgtc gtccgcggcg aggcggccac ccgcaccttc tgcgccctgg ccgcactctg
    26581 cctcgcccag ttctccctgc tcggcgcccc ctggaccacg acgcccgtgc cgctgaccac
    26641 cggcgcgctg gccctcgccg tcggcgccac cctgctgacc gcccgctgcc tcgccccgcg
    26701 cacggtcgcc ccgcgcagcc cctaccgcgt cgccatggcc acccagtacg gcgtccatct
    26761 cgccaccgcc gccgccctgt tgctcggtat gtgagacatg cccggcatat gagacgcgta
    26821 gtgccgatca caggcacgcg gcgcacactg ccaggggttc ttgaatgatt ctttgcggca
    26881 ggccacgttg catgtaatgg aacattgcta cggtctgcca cgtcggctgg agcggcccca
    26941 cacgtcccgg ctgtcgagac aggaggggga agcgccggga tgtctgccac cgccgggtca
    27001 ccgcccgagc ggcgcgccgc cgtggtcgag gcggtgatcg ccgcgtacgc cgcaggactc
    27061 agggaggccg acagcgccct cgtacgcaac gacaggatct ggaactccgc gcgcgaccag
    27121 gcgcgcgaca tcctcaccga gtgcctcgcc gcgctgcacg gcgagcaggt gcaggtcgcc
    27181 atggaggccg aactcacttc catggccctc gggatgcgcc gcgccttcga gcagatcccg
    27241 cccatcgact cgctgttcgc cgcgcacgtg ctgttcgagg tcggcaccga cgccctcgtg
    27301 gaggaggccc gcgccttccc cgccgggacc ggcatgagcc gcctcacgcg cgcggtgcgc
    27361 atgctgcaca gctccatctc cacgcgcgtg cgggccgccg ccatcggcta cgaggcgtcc
    27421 acgctgcgcg gcgtcggcgc ggccaacacc gcgcgccgcg accagctggc ccgcgacatc
    27481 cacgaccaca tcggctccag cctggccctc gcgctgcgct gcctggacct gtacgaggcc
    27541 gacctggccg ccggcggcag cgcgcagagc cggatcgcgg acgcccggca ggcgctgcgc
    27601 gacacgttcc gcttcacccg ctcgctggtc agcgggctgc gcagctacga actgagggac
    27661 agcctgcagg ccgagatcag ctcctacacg caggccgcga ccgacggcgc gcaggtcgtc
    27721 gtcggtatca acggcgacga ggcgtggctg cctgccgacc gccgcgagga gatcttcctc
    27781 gtggtccggg agtgcctgcg caacgccttc acgcacgccg ccgcctcccg gatcgacgtg
    27841 gacgtcacca tcgccccgga ctgcgtcgcc tgcaccgtcg aggacgacgg ccggggcttc
    27901 gacccggcgg cgccggcgac cggccgcagc ggcggcatgt cgtcgatgcg ggagcgggtg
    27961 accggcctcg gcggcaccct gcgggtggcg agctatccgg ggatcggcac acgggtccac
    28021 ttccaggtgc cgctgccgga ggtggcggcg gtggacctgg tggaacggga acacacctga
    28081 ccgacgaacg aacggacaag ggggacatcg ggggatgaac gggggacttg agatgagtga
    28141 ggacatcggt gcgccgggcg gcgcggatac gacgaggccg ggccacgggg gtccggtgag
    28201 gccggcctac ggggatccgg tgaagccggc cggcgggggt tcggtcgggc cggccggcgg
    28261 gaggaccgcg gggcaggtcg gcgcgcggcc ggtcggcgcg gccggtgggc ggcgagagct
    28321 atggcccgcc gtggccggtg gccggcggga gatccggatc ctcgccgcgg acgaccacag
    28381 cctgctgcgg ggcgcgctgt gcgagctgct ggacctgcac gacgggctga ccgtggtcgc
    28441 ccaggccggc gacggcccgt ccgcggtcgc gctcgcggcc gagcaccagc cggacatcgt
    28501 gctgctggac gtggagatgc cgggcccggg cccgctgcag acggtgcggg cgctgcgcga
    28561 gcgggccccg caggccagga tcgtcgtcct gaccatgcac gacgacgcgc ggctgatcga
    28621 gtcgctgctc aaggcgggca cctccgccta cctgcacaag gaggtcgacc gggagatcct
    28681 cgtctcggcg atccgcagcg cgatggcggg cggcaagacc acgttcctgc cccgcccggt
    28741 gcccccgtcc ggaccgcacc cgctgaccga ccgggaacgc gagctgatga ccctggtcgc
    28801 ggagggcctg agcaaccgcc agatcggcac ccggctcggc atagcggagg gcacggtcaa
    28861 acggcacctg cggaacgtgt tcgacaagct gggcgcggcg tcacggctgg acgcggtgaa
    28921 ccggctgcgg gagttcgaac cgttctgacc ggcggaccgg gtgcccgccg cccgcagacc
    28981 ccgtagtacc tgagagggac gccgaggaac cccctccaag gggacgaccg cgcgggcggg
    29041 gccgccttac ggttccgaca tggccgagac gaccaagacg caccccacca cgagcggacc
    29101 gggcgagggc gaccaccccg cgtacgtgcc gcgcagcccg gagttccgcg cggccgcgca
    29161 ggcgctgcgc ggcatgcggc aggacctgct gcacgacgtg ttcgcctacc gcccgctgcc
    29221 ccgcctcgcc gcggacgcgc ccttcgtacg gcgcttcccg gcaccgctgc gccgccacgc
    29281 ggtgtgggcg cggcacgcgc tcgtgctcct cctagcgtgg gcgaccctgg cggccggcgc
    29341 ctccacgggc tacgacctgg cctccccggt ctacgtcgtg accagcgtga tcccggcggc
    29401 ggcggtggtg ctgacgctgc tgcggccggt ggccgcgttc tggctgtcgc tcggctcggc
    29461 cgcgctgctc gccgtgctcg gcgtcgactg ggacggctgg ccgttccagc cggccggctt
    29521 cgccgggcac ctgtcggtgc tgacggtggt ggcgctgcgc acccggccgc gtacggcggc
    29581 gtggatgtgg ctggtgaccg cggcgtacgg cgtgctgacg gggccgttcg ccgcctaccc
    29641 ctacggcggc tcggactcgg tggagttcct cttcctctcc gcgctcgtcc tgctcgccgt
    29701 gacggtctgg cacatacgcc gggacgcgga ggaggaggtg accgcccagc agacggtgac
    29761 ggagcacgaa cgctcgcggc gcaccctgct ggaggagcgc acgaccatcg cccgcgagct
    29821 gcacgacgtg gtggcgcacc acatgtcggt ggtggcgatc caggccgagg cggcgcccta
    29881 ccgggtggag aacccgccgc cggagctggc caaggcgttc gccacgatcc gggagaacgc
    29941 ggtggcggcc ctgaccgagc tgcgccgcgt cctgggcgtg gtccgcgccg aggactacga
    30001 ggcccccgac gcgccccagc cgaccctggc cgacctggac gccctgctcg cgaacgtgcg
    30061 cgaggcgggc ctgacggtgg acaggacggt gacgggcgcc gtccgcgaac tcccgcaggg
    30121 ggtggagctg tcggcgtacc ggatcgtcca ggaggcgctg agcaacacgc tgcggcacgc
    30181 gccgggcgcg acggcacggg tggagatcgg ctatgtcatc ggcggcctgg gcctgcgcgt
    30241 ggtgaacacg cccccgccgg cgcccgcgcc gtccgccgcc tcgccgggcg cgggacacgg
    30301 cctgacgggc atgcgcgaac gcgtgacgat gctgaacggc gagatgacgg cgggcccgac
    30361 accggagggc ggctacgagg tgacggtgta cctgccggcg cgcacgcccg gtgaggacgg
    30421 cgggacggca tgacgatccg cgtactggtc gccgacgacc agatgatggt ccgcgagggc
    30481 ttctcggtcc tgctgaacgc gatgccggac atcgaggtga ccggcgaggc ggtgaacggc
    30541 cgcgaggcgg tggcgaaggt ccgcgaactc gccccggacg tcgtcctgat ggacatccgc
    30601 atgccggagc tgaacggcat cgaggcgacg cgtgagatcg tcgcggcgga cggcaccgcg
    30661 aaggtgctgg tcctgacgac gttcgacctc gacgagtacg tctaccaggc gctgcgcgcg
    30721 ggcgcgtcgg gcttcctcct gaaggacgcc tcggcccgtc agctggcgga cgcggtccgc
    30781 gtggtggccg cgggggaggc gctgctggcc ccgtcggtca ccagacgcct gatcaccgag
    30841 ttctcccggc tctcggaacc gtcccacccc ctgtccggcg cccacgcggc ctacggcgac
    30901 ctgaccgacc gcgagacgga ggtcctggtc ctcatcgcgc agggcctgtc caacgcggag
    30961 atcgccggac gcctggtggt ggcggagtcc accatcaaga cccacgtgag ccgcatcctg
    31021 gtcaagctgg gcctgcgcga ccgcacgcag gcggcggtgt tcgcgtacga ggcacggctg
    31081 gtgacccccg gctgacggcc gcggcggctc tggaaggctg acggcatgac gacgctcgcg
    31141 ggatacgaga accgccccct ggcggacggc gggccgctgc tcggcaggcc gggcttctgg
    31201 ccgaaccacc tctgggcgcc ctgctgccag gaggccgggg ccgggccgga gcggttcggc
    31261 gccgacgggg cggacgtgga cgcgctgtac gagacgctga cggatcccgg ccgctggccg
    31321 gtgttccggg tgccgtgcgc ggacggccgc gaggtgacgg tcgtctacca caacctcgtc
    31381 gacgaccccg gtgtcgcgta cctgctcacc gcccccggcg acagcggccc gcgcccgctg
    31441 cgggcgctga cctggcggga gctggaccgc gccgcccacg gaccgctccc cgccaccggc
    31501 gccgacggga tcaccgaccc cgcggcccgc ctcctgctgc tgttcccgct gctcgacgac
    31561 cacgccgtcc cggacgaggc ggcggcgacg gtcgagtccg ccctggtcgc ggtgggcgcc
    31621 ccgcaggaca cggcccccgc cacggcccgg cacctgctgg accacgcggc gggcgaggtg
    31681 tggcacgacc cggagtggga ttccccgctc agcggcgcgg agccggaagc cgcgcggagc
    31741 ccctggtcag accccggtcc gccgcgttag cgtcgccgca tgtccgacgt ggcccgcctc
    31801 gccttcgacc cctgggaccc ggccttcctc gccgacccct accccgccta cgccgagctg
    31861 cgggcgcgcg gacgggtgct gtactacgag ccgacggacc agtggctcgt gccccggcac
    31921 gcggatgtgt cggcgctgct gcgggagcgg cggctggggc ggacgtatct gcaccggttc
    31981 tcgcacgagg agttcggccg gaccccgccg ccggcggaac acgagccgtt ccacaccctc
    32041 aacgaccacg gcatgctcga cctggagccc ccggaccaca cccggatccg gcggctggtg
    32101 tcgaaggcgt tcaccccgcg gaccgtcgag cggctcaagc cgtacgtcga acagctcgcc
    32161 ggcgacctcg tcgcccggct cgtcgaggcg ggccgcggcg atctgctcac cgacgtcgcc
    32221 gaaccgctgc ccgtcgccgt gatcgccgag atgctcggca tccccgacgc cgaccgcccg
    32281 ctgctgcggc cctggtcggc ggacatctgc gggatgtacg agctgaaccc ctccgccgag
    32341 gccgccgatc gggccgtccg cgcctccgtc gagttctccg actacctgcg cgacctgatc
    32401 gccgcccgcc gcagggaacc cggcgacgac ctgatctccg ggctgatcgc cgcccacgac
    32461 gagggcgacc ggctcaccga gcaggagatg atctccacgg cggtcctgct gctcaacgcc
    32521 ggccacgagg ccaccgtcaa cgccacggtc aacggctggt gggcgctgtt ccgcaacccc
    32581 gcccagctgg ccgccctgcg ggccgaccac tccctcgtgc ccacggccgt ggaggagctg
    32641 atgcggtatg acaccccgct ccagctgttc gagcgctggg tgctggacga cctcgagatc
    32701 gacgggacga cgatcccgcg cggcgccgag atcgccatgc tgttcggctc cgccaaccac
    32761 gatccggacg tcttcgacgt ccccgaccgc ctcgacctca cccgccgcga caacccgcac
    32821 atctccttca gcgcgggcat ccactactgc atcggcgccc cgctggcccg catcgaactg
    32881 gccgcgtcca tgcgggccct cctcacccgg gcgccgacgc tgaccctggc ggcggagccg
    32941 gaacgcaagc cgaacttcgt catccggggg ctggaggggc tgagcgtcga ggtcgggtga
    33001 tcactcgttc ggatgagcgc cgatcgaatt cgggccgggg cggctcgcaa cacgtcacgc
    33061 tggtgccggc ctgcggaggg aggcaccatg acggtcatgg cagagcgcgc gtcgtctcag
    33121 ttgtcggtgt ccatgttcga gcggatcgcc gagttcgccg agcgtgagga cgaggccgtc
    33181 aggttcgagt tcatcgacgg acggatcggg ctcaacaagg tgacgaacgg taaccacggc
    33241 gagatcgcca tgtggctcgt gttccagtgc aagcaagctc gccctgaact caccctcaac
    33301 accacacagg gactcaaggt cgaggcctac cgcaagggcc gggcccgtcc cgacggcgtg
    33361 ctcgcgcctg tcggccactt cgccgggaag ggcgactggg cggaccccga cggcgtgctg
    33421 atggccgtgg agatcacgtc gtacgacgcg gacacgcaca accgcgaccg gatcgagaag
    33481 ccccgtgcct acgccgaggc cggcatcccg gtctacctgc tcatcgaccg cgacaggctg
    33541 tcggtcctcg tgcacagcga ccccgacttc gaggacggat accgggacat ccacgtggtc
    33601 cgtctcggcg gcaaggtcac cctccccgaa ccggtcggca tcgaactcga cacggcgcat
    33661 ctcaagcagt acctcgactg agcccacgga cgcgcacccc acgccgccgg gtcgccgcag
    33721 gcctcagctc tccaggtccc gcctccgcac ccccgccagc cccgccgccg tgcacaccgc
    33781 cgccaccccc agcagcaccc ccgccggccc ccaccgcatc tccccgcccg gcagcttggg
    33841 gaggtggccg aagggggaga ggtccaggac cgtctgcggg acgtccagcg cggggccgat
    33901 ccagccgagc aggaggaccg cgccggccac cgcccacgcg gcgaccgccg ccctgggcag
    33961 cagcccgtac agcaggaccg ccagtccgcc gaccacccac accgccggca cctggaccag
    34021 gcacgccgcc aggatcgggc ccgcctcgcc gccgtagccg gccgtgaagc cgaggcccgt
    34081 cagcagcatc agccacacca cccccgcgaa cgcgatcagc agatgcccgg acgcccagcg
    34141 cagccggccc accgcgcccg ccagcaccgg ctccgcccgg cccgaggtct cctccccgta
    34201 cagccgcagc accgacgcga ccacgaacag cccggcgacc aggcccatca ccccgatcat
    34261 cgacgcgagg aacgcgtccg tgagcccgga ctgcccgccc atccgctcga agatctcgcg
    34321 ggcccgctcg ttgtcgccga ccagatcggc cgccccctcg gtcatcccgc cgtagacgac
    34381 ccccgcgagg aagaagccga tcgaccagcc cagcacgccg ccccgctgca accgccaggc
    34441 cagcgccccc gccgaggcca gtcggcccgc cgccggtccg ggccgcgtcg gcaggaagct
    34501 catgccgacg tcccggcggc ccgccagccc gtacgccacc gccgcctgca cggccaccgc
    34561 cgcgccggac agcagcagca cccaccagcg ctcaccggcg tacgcgcgga cgttctccgg
    34621 ccagcccagc ggcgacagcc aggtcagcac cgacgagccg tcgtccgtcg ccgcgtcccc
    34681 cgccgcgcgc agcacgaacg ccgcgcccag cacgcccgcc gcgatgcccc gggccagccg
    34741 cgcgctctcc gtcagctggg ccgcgatcgc ggccgtcgtc gcgaacacca ggcccgtggc
    34801 cgcggccccg agcgcgaagg ccacggcacc cgccgcgccc agccgggcga gaccggcggc
    34861 cagcagcacc gcgaggacgg cgtcggcgac ggccgccgcg agcagcgccg ccgtcaggga
    34921 cgcccgccgc cccaccgccc cggacgccac cagctccgcc cggccgctct cctcctcgtc
    34981 ccgggtgtgc cgtacgacga tcagcaggct catcaccgcg gcgagcgcac cggcgtacac
    35041 gccgatccgc caggccgtca gcgcgccgag ggagtcgccg aacacggggc cgaccatcgc
    35101 gcgcagcgag gagttggcgg ccatctgccg cagcaggtcg gcgcgttcgg cgtcggtggc
    35161 gtacaggttc cgcagggtgt tcggcatgga cagcaccatc agggcgttga ccgcgatcca
    35221 caccggggtc atcacccggt cgcggcgcag cgcgaaccgc agcagcgtgc cggtcccggc
    35281 gagttggcgt ccgccgccgg accgtcgtac cgcgagcgtg gccgtcatgc cgtcacctcg
    35341 tcctggtagt ggcgcaggaa cagctcctcc agcgtgggcg gcgtcgaggt cagcgaccgc
    35401 acccccgact cgctcaacct ccgcagtacg gcgtccaggt ggccggtgtc gacctggagg
    35461 cggacgcggc tgccgcgcac gtcgaggtcg tgcacgccgg ggaggcgggc gaggccgtcg
    35521 ggcggtccgg ccagctcggc ggtgacgctg gtgcgggtga ggtggcgcag gtcggcgagc
    35581 gagccggtct ccacggtccg gcccttgcgg atgatgctca cccggtcgca cagctcctcg
    35641 acctcgctga ggatgtggga actgagcagg accgtccggc cgcgctcgcg ttcctcctcc
    35701 acgcaccgcc ggaagacctc ctccatcagc gggtcgaggc cggaggtcgg ttcgtcgagg
    35761 atcagcaggt cgacgtccga ggcgaacgcg gcgaccaggg cgaccttctg ccggttgccc
    35821 ttggagtacg tgcggccctt cttggtcggg tccagctcga accgctcgac cagctcggcc
    35881 cgccgcttgg ggtcgaggcc gccgcggagc ctgccgaaca ggtcgatgat ctcgccgccg
    35941 gagaggttgc gccacagggt gacgtcgccg gggacgtagg cgatccggcg gtgcacctcc
    36001 accgcgtccg cccagggatc gcggccgagg acatgggctg cgccggagtc ggcgcgcagc
    36061 aggccgagca ggacacggat gatggtggac ttgccggcgc cgttcgggcc gaggaagccg
    36121 tgcacctcac cggcctcgac ctccaggtcc agcccgtcga gcgcgtgcgt ccgtccgaac
    36181 gccttgtgca gtccggagac ggtgatggcc ttcgtcatgc ttcagaacgt acgcttactt
    36241 cagaaatttg tgaagttaag gaaccatcaa aacggggcga tagactggcg gaggccggcc
    36301 gaccagggga gatgatcgag cgatgacgga gccgaaggag gcggggcgcg accccgagac
    36361 gctctcccgg ttcgtggagc acttcgccgc acagctcgtg gaggcggggc tgccgcgcat
    36421 gccggcccgc gtcttcgcgg ccctgctcgc ctccgacacc ggcacgctga cctccgccga
    36481 gctgggcgaa cagctccgga tcagcccggc cgccgtctcc ggcgcggtcc gctacctctc
    36541 ccaggtccac atgctctccc gcgaacgcga gccgggctcg cgccgcgagc gctaccgcgt
    36601 ccacagcgac cagtggtacg aggccctcac caaccgcgag gccgtcatca agcgctggga
    36661 ggacgccctc cgagagggca tcaccagcct cggccccacc accccggccg gccgccgcct
    36721 caccgagacc ctggccttct tcgagttcat cgagaaggac gtggccggaa tgatggaacg
    36781 ctggcgcgcc caccgggagg agaggttcgg agcctgagta actgatcgga tacgctgcgt
    36841 gctgggtggt ctgcggcagg gggaaggcgc atcatgacgt tgatgacagt gcgaccgatg
    36901 gcaagcggca gcgatccctt cagcttcgag gaactgctcg acgctctcga cgagttggac
    36961 gcacctggct tccgggccga ggtcatcagg gggagcatcg tcttgtcgcc gtggtccaag
    37021 gggtactacc gccgcgtcat gcgcgcggta ctcgagcagc ttgagccccg tcttcccgac
    37081 gggcacgaga tcgagctggc cccgttcctg tacgtcttcc cgggagaaga gcgggcgtac
    37141 ggcccggaca tccacgccgc accccgagag gccttcgaga cgacgagcaa ccgcctcgac
    37201 ggcgaagccc tctccttcgt ggccgagctg acctcggcct ccacccgcga cgatgacctg
    37261 accgacaagg tgctcgtcta cggcagggcc ggtatccccg tctacctcgt cctggacatg
    37321 caggaagaac aggccaccgt cttctggacc ccgtcgccca ccaagggcta cgagtcccac
    37381 tgcacgaggc ccttcggcga gaagctgccg atcccggccc cgttcgactg caccctcgac
    37441 accgacggct tccgcgcccc ggcagcggac caggaccaga acaccgcctc ctgatgccgg
    37501 ggccgggact cagcgcgccc ccggccccgc cggcagcgtg atccccaggg ccccctccag
    37561 taccgtccac gtccggcggc gtaccgggcc cgagacgcgg tcgtcggcgt ggtagcggaa
    37621 gtccgcgccc gagacggaga ccgtgcggcc ctcgctgagc agcggggacg cctccgcgcc
    37681 gaccgaggac gggcggacct ccacgaaagc ggtgccggag gtgccggggg tcagggacac
    37741 cgcctcgacc ggctggtcca ggtccaccac cgtcaccccg tccacctcca cgcgcagccg
    37801 ggacgggccg gccgccggca gcgtgcggac cgggcgcagc gggaccagcg tgcggaccag
    37861 ggactggcag gtgcgcagcc acggccgggc cccctccgga tccgcttccg cctccggcat
    37921 ccgctcccgc agcggcggga tcccgaccgt ccccagcacc accccgtcgc tgtcgtccac
    37981 gaggacgtcc agccgccgta ccgccccgtc cagcaccgcg cgcgccgccg ccaccgcgcc
    38041 cgtcggcacg ccgagggagc gggccacggt cacggccggg ccgaccggga cgaccgacaa
    38101 cacggatccg gccagctccc gctgccggtg cagcaccgac accgcgcgca ccagcgcccg
    38161 gtcgtcaccg atcaccaccg gccgccgcga cccgcggcgc gccagcgcgc gggcgaactc
    38221 ctccgggtcg tccggcaggc acagcttcgt cgccgcaccc gcgctgagca cgtcttttgc
    38281 gatccggacc gcctctccgt ccgtcctccg ggcgatcgga tcgacgatca ccagcaactg
    38341 ttcggacgtc ggataggtcg ccacctcggt cctgcctcgc ttcctcgggt agcatctttg
    38401 tgcaagagcc ccttgcgcta ttgcgccagg ggcttcgtct attccggggc atccggtccg
    38461 acggttggcg gccaatgacg gccgcggtgc acgcggcggt agaccctccg cgtacgcccc
    38521 tgaccctgga catgccccgc ccggaagggg tgtacgcgcg tgcccgcact tgtgctgctc
    38581 ggtgctcagt ggggtgacga gggcaaggga aaggccaccg acctgctcgg tggatcggtg
    38641 gattatgtag tgcgctacca gggcggcaac aacgccggcc acacggtcgt cgtgggtgac
    38701 cagaagtacg cactccacct cctcccctcc ggaatcctct cccccggttg tacgcccgtc
    38761 atcggcaacg gcgtcgtcgt cgacccgtcg gtcctgctct ccgagctgag cggtctgaac
    38821 gagcgcggcg tcgacacgtc gaagctcctg atcagcggta acgcgcacat catcacgccg
    38881 tacaacgtga ccgtcgacaa ggtcaccgag cggttcctcg gcaagcgcaa gatcggcacc
    38941 accggccggg gcatcggccc gacctacgcc gacaagatca accgcgtcgg catccgggtc
    39001 caggacctgt acgacgagtc gatcctccag cagaaggtgg aggcggcgct cgacgtcaag
    39061 aaccagatcc tcaccaagct gtacaaccgg cgggccatcg ccgccgacca ggtggtcgag
    39121 gagctgctgg gctacgccga gaagatcaag ccgtacgtcg ccgacacggt cctggtcctc
    39181 aaccaggccc tggaggacga caaggtcgtg ctcttcgagg gcggccaggg caccctgctc
    39241 gacatcgacc acgggaccta cccgttcgtc acgtccagca acccgaccgc gggcggtgcg
    39301 tgcaccggcg cgggcgtcgg cccgacgaag atcagccggg tcatcggcat cctcaaggcg
    39361 tacaccaccc gggtcggcgc cggtccgttc ccgaccgagc tgttcgacga ggacggcgag
    39421 gcgctgcgcc gcatcggcgg cgagcggggt gtgaccaccg gccgggaccg ccgctgcggc
    39481 tggttcgacg ccgtcatcgc ccggtacgcc acccgcgtca acggcctgac ggacttcttc
    39541 ctcaccaagc tggacgtcct caccggctgg gagcagatcc ccgtctgcgt cgcctacgag
    39601 atcgacggca agcgggtcga ggagctgccg tactcgcaga ccgacttcca ccacgcgaag
    39661 ccggtctacg agatgctgcc gggctggagc gaggacatca gcaaggcgaa gtccttctcc
    39721 gacctgccga agaacgccca ggcgtacgtg aaggcgctgg aggagatgtc cggcgccccg
    39781 atctccgcga tcggcgtcgg cccgggccgg gacgagacga tcgagatcaa ctcgttcctg
    39841 taggtcacac gccggtcggt cacgcgccgg taggtcacac gtcggccaca gctgacggaa
    39901 acgggcgcct cccgcaagcg gaggcgcccg tttggcgttc gaatggagca tgacccggcg
    39961 cgaggtgcgg tgcctggggc cgtacggcgg tgaggtcgag gacaccggct gcggcgagcc
    40021 cgcccggttc gagctcgtcc gccaccggcg cccgccgctg cacctgtgcc ccgtccacct
    40081 cggcccggcc ctgctcctcg cggacggcgt gctgtggccg cccgagatcc ggctcatcgc
    40141 ctgaccgccg gccgtcggtg cgcggcccgc tcactccgtg cgcagcgccc tcaccgtgtc
    40201 cgtccgggcc gcccacccgg ccggggccag cgcccccgcc accgcgatca ccacgccgcc
    40261 cagcgcgagg gcggccgtca ccgcgggcgc gtacaccgcg atgtccggct ccggcaggcg
    40321 catgccgacc gcgtcgccca tcagcggggc gatccagtgg tgcagggcca ccccgagcgg
    40381 cacccccgcg gccccggcga gcaggcccag cgcgcccgtc gaggtgagca ccatggcgac
    40441 ggtctgccgg ggtgtcatcc cgaccgcctt catgatcccg aggtcgcgga cccggtcccg
    40501 ggtgtccagc acgaccgtgt tgagcacgcc cagcccggcc accgcgacca gcagcgcggt
    40561 cagcgtgccg atcagcgcgt ccatggctgc gatcacgctg gaggcgcggt cgggagcggg
    40621 ccgcgcggtc gcgccgagcg gctccagggc cgtacgcacc gaggccgcgt aggcggaggc
    40681 ggacaggccc ggcgagggtt tcacgtgaaa ccgttccggc acggcggacg ggtccagccg
    40741 ccgcagcgtg cccagcgagg tgagcagccg catcccgtcg ccctcggtga agaacgcctc
    40801 cccggtgatg cggacggcgg tccggcggcc gtggccggcc agcgtgacct cgtcgccgac
    40861 ccgcacaccg gccgcgtcca ggaaccgccg ggtgaccacc gcctcgccgt ccccgccgag
    40921 ccagcgcccc gacaccagct gcggggcggc ccaggaggcg tcgccgtcgt aggcgaggac
    40981 gggggtgcgg ccgctgacgc cggtcgcggt gacctcggcc tgcgtggtgg cgtagaagcg
    41041 gtccgtgtgc cggtcggcgc gcagcgcggc ggcgacccgg accgggtcgg ccgggggccg
    41101 gtcggacggg ccgcccacgt gcacggccag agcgccgggc ggagcgctgc cccggccggt
    41161 g
//