LOCUS       NZ_BNBR01000002        21830 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000002
VERSION     NZ_BNBR01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1230061)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 107817
            Orig. end                         :: 129647
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21830
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="blactam"
                     /region_number="2"
                     /rules="(BLS or CAS or tabtoxin)"
                     /tool="antismash"
     cand_cluster    1..21830
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(BLS or CAS or tabtoxin)"
                     /kind="single"
                     /product="blactam"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21830
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11830](+)"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11830
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
     gene            complement(138..881)
                     /locus_tag="IE308_RS09570"
                     /old_locus_tag="GCM10018783_19650"
     CDS             complement(138..881)
                     /NRPS_PKS="Domain: PKS_KR (11-186). E-value: 8.8e-09.
                     Score: 27.5. Matches aSDomain:
                     nrpspksdomains_IE308_RS09570_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104168.1"
                     /locus_tag="IE308_RS09570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19650"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_110625927.1"
                     /transl_table=11
                     /translation="MSETNTVNHPKVALVTGANKGIGYEIAAGLGALGWSVGIGARNEE
                     RREAAVDKLRAAGADAFGVPLDVTDDASVTAAARLIEERAGRLDALVNNAGITGGGPQE
                     PTTVDVNRVRAAVETNVIGVIRVTNALLPLLRRSPAPRIVNVSSSVGSLTRQSTPGAET
                     GPIAVAYAPSKTFLNAVTVQYARELADTNILINAVCPGYTATDLNGFRGVRTPRQGAAI
                     AIRLATVSADGPTGRFFDDEGEVPW"
     aSDomain        complement(324..848)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS09570_PKS_KR.1"
                     /evalue="8.80E-09"
                     /label="IE308_RS09570_PKS_KR.1"
                     /locus_tag="IE308_RS09570"
                     /protein_end="186"
                     /protein_start="11"
                     /score="27.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGANKGIGYEIAAGLGALGWSVGIGARNEERREAAVDKLRA
                     AGADAFGVPLDVTDDASVTAAARLIEERAGRLDALVNNAGITGGGPQEPTTVDVNRVRA
                     AVETNVIGVIRVTNALLPLLRRSPAPRIVNVSSSVGSLTRQSTPGAETGPIAVAYAPSK
                     TFLNAVTVQYAR"
     gene            986..1834
                     /locus_tag="IE308_RS09575"
                     /old_locus_tag="GCM10018783_19660"
     CDS             986..1834
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524838.1"
                     /locus_tag="IE308_RS09575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19660"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_190217504.1"
                     /transl_table=11
                     /translation="METRELRYFVAVAEELHFGRAAQRLGIAQPPLSRAVAGLERRLGT
                     LLLERSSRGVTLTGAGAVLLREARAALDAVEAAERRTRRAALAATGHPTVVLAAKAGAS
                     GELLAKLLDAYAAEPGAVAVDVVLCGPGEQARLLHDGRADVALLHRPFDDTAGFDTEDL
                     HTEGQVAILPAAHPLSARPHLRLAEVTDLPDLPLPRWPHPDGTFPDGPGPQVRDHTQLT
                     QLIALGRACAVVPESGSTGLREGLTAVPVPDAPHVTTVIAWPPHSHSTAVAALVRAATD
                     L"
     gene            complement(1936..3123)
                     /locus_tag="IE308_RS09580"
                     /old_locus_tag="GCM10018783_19670"
     CDS             complement(1936..3123)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="IE308_RS09580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19670"
                     /product="MFS transporter"
                     /protein_id="WP_190217505.1"
                     /transl_table=11
                     /translation="MGDGLWFSMWAVYLTAVQGVPAATMGLAMGLGGGLGLLAALPVGT
                     LTDRLGARETLVAVTVLRAAFSLTFLATHTFWPLLVAAALFTSMETAAKGSKVALVHLL
                     VPERDCLPVLARARVVQHILYAAGAGAAAWVLSRQSAAPYHGAVVVNSLTFVVSAALLA
                     RLPHVPPAPAARRHLSTEALRNIPFTAIMSSTALLALCWALLSSGLPLWLKEDTTAPVW
                     IAPLSVLASSLLIALFQVRVTRTGQRLAGAVRSSWRASVALAACCLVFAAAAWPAGPAV
                     AAVVVLAGLALHVLGELYYVAARWGLSIKLMAHGAQGQYQAVAATTEGAVVAIGPALVV
                     TLISGAGGAGWGILALILLTCSLPVAPLCRSAVRRAGSRSVKGSSEPERVSHPQG"
     misc_feature    3391..3404
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.29"
                     /tool="antismash"
     gene            3695..4435
                     /locus_tag="IE308_RS09585"
                     /old_locus_tag="GCM10018783_19680"
     CDS             3695..4435
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (12-242). E-value: 9.9e-27. Score:
                     86.3. Matches aSDomain:
                     nrpspksdomains_IE308_RS09585_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014698.5"
                     /locus_tag="IE308_RS09585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19680"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_110625930.1"
                     /sec_met_domain="TauD (E-value: 1.9e-25, bitscore: 86.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHSPLSILSQVDFNGDPLTDELLMKTFHQLMDEHGYVLMCNVPE
                     EFDPVRFCRNLGRFVPNYTGAVVGDVRPEPGMDDVYHAGNTRPLTPHSEGYDFAVVPPR
                     YIALWCVTPAGGPGGETTLADTRPWVESFTAEEREWFLTHEYDWKTTEGVQRLGLDLKT
                     RHPVLEETDQGTIVRFSCNNLIRDDGDPAAELQQRWHAAFDREHVSIDYSEKDMLVWDN
                     WRLLHARNAFSDRNRHLRRIQIAA"
     aSDomain        3731..4420
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS09585_TauD.1"
                     /evalue="9.90E-27"
                     /label="IE308_RS09585_TauD.1"
                     /locus_tag="IE308_RS09585"
                     /protein_end="242"
                     /protein_start="12"
                     /score="86.3"
                     /tool="antismash"
                     /translation="DFNGDPLTDELLMKTFHQLMDEHGYVLMCNVPEEFDPVRFCRNLG
                     RFVPNYTGAVVGDVRPEPGMDDVYHAGNTRPLTPHSEGYDFAVVPPRYIALWCVTPAGG
                     PGGETTLADTRPWVESFTAEEREWFLTHEYDWKTTEGVQRLGLDLKTRHPVLEETDQGT
                     IVRFSCNNLIRDDGDPAAELQQRWHAAFDREHVSIDYSEKDMLVWDNWRLLHARNAFSD
                     RNRHLRRI"
     gene            4462..4899
                     /gene="panD"
                     /locus_tag="IE308_RS09590"
                     /old_locus_tag="GCM10018783_19690"
     CDS             4462..4899
                     /EC_number="4.1.1.11"
                     /GO_function="GO:0004068 - aspartate 1-decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006523 - alanine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136515.1"
                     /locus_tag="IE308_RS09590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19690"
                     /product="aspartate 1-decarboxylase"
                     /protein_id="WP_190217506.1"
                     /transl_table=11
                     /translation="MYRTMLHSKIHRATVTQADLHYVGSLTLDRDLMDAADLLPGEKVD
                     IVDINNGNRLSTYVIEGERGSGVVGINGAAARLISPGDLVIVIAYQSVSAAEARDLQPN
                     IVFVDQHNRPLDIGGDPAHVPADPAAASLMRGDTLAHGAVR"
     misc_feature    4762..4764
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4896..6266
                     /locus_tag="IE308_RS09595"
                     /old_locus_tag="GCM10018783_19700"
     CDS             4896..6266
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040296.4"
                     /locus_tag="IE308_RS09595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19700"
                     /product="DUF6002 family protein"
                     /protein_id="WP_229908795.1"
                     /transl_table=11
                     /translation="MTTVSPAPATALAPAGPGTVCRALLRYYDDLSRVLADTGSRDRTA
                     GFSPGWRLPAPGPALERFFEPGGISAQDLGSYHDTPLRFLNLMHNPRTRTTKTLASLLI
                     VARAVDHIQRTGESVLIITPSSANKATALRDAVLRAHETGLVGADQLRIVCVVPAASSH
                     KLWRSPLTDDDVLRARNPLAVLDASQPLHVKELARALADREADALFARYGVRLWHTMDL
                     SNYAVADTARALFERDHLPAAPRVHAHSVSSAFGLLGHFYGQQQHTGRDWPGTGARYFL
                     VQHLGTPDMVSSYYHGRFDYRPQWQYRDGLHVQDSDPRFPGRTFAPDEQLDTTFYTRTP
                     ATSERMNEIIRRQGGGGIVVSLAECLDRYPLVRDLLQPAGVELPADPRQIREWSLVMAV
                     TGVLNALDRGLLDETEILVHGSGSYHADDYRAPQADQLRPITGYGDLRDLVHTAAVS"
     misc_feature    5421..5423
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6279..7529
                     /locus_tag="IE308_RS09600"
                     /old_locus_tag="GCM10018783_19710"
     CDS             6279..7529
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024871.5"
                     /locus_tag="IE308_RS09600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19710"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190217507.1"
                     /transl_table=11
                     /translation="MTTQDHTLPTAAAPPSPTPAGVGGGGRPARHHPLAPVRARIAYWW
                     NNTPAPGWRAVRSRTDSLPRSVPVLSSLTGQDGPSIGYAGLPVGRTNILQLLEHQRTQL
                     GWATVRRTDSTLRWGDLAAGDWPDTDLVVVGAEERVLRHLPEQGSVTAPFRLHLVVDVP
                     PSQEELARLISKRERWQFRRDQREHQWVLEEDSSPEALTFFYNRMHGPTMRNRHGDRSR
                     TEPLDVARYAVLRRGTLFFLSQAGTRVAGVLCHWSKDRRTLTTRLLGVLDGLDEHYRTG
                     AFKALYHHLLRWACEQRVARVDLFGTEAYISKGIFQWKRRLGAHPEWPANHFATKRVRI
                     YPRRDTPAVRDFLVANPLVRTDARGGLTPVYYTDDDRPPRLDLSARCPGLAEPEVVHLD
                     TVLQPVALHEPSRGGRR"
     gene            7526..8632
                     /locus_tag="IE308_RS09605"
                     /old_locus_tag="GCM10018783_19720"
     CDS             7526..8632
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS09605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_19720"
                     /product="potassium transporter TrkA"
                     /protein_id="WP_190217508.1"
                     /transl_table=11
                     /translation="MNRSRHVVVLGTGAFARALVKAFAQRAGGPTVVHIVSGDHDRARH
                     LAGLANAHAALADRPVRCCPHRLDVPDGADLRPLLGRHQPDVLAVCASEYSPAETRGTK
                     TAWAELIRAAGFGVTLPLQAATALRAASAAAEASPRTAVLNACFPDAVNPVLHGAGLPV
                     LCGLGNVSTLVSLIRSELRIGDESRLKVLAHHAHLHAPPTPDQEVRAWLDEQPLTAVHD
                     ILRRERRRPRADLNEIGATAGAAVLDALTHPRDYFAGHAAAPQGRPGGYPVVITGRSIA
                     LRLPPGMSERQAVARNQEWSALDGITVDQQGKAHFTPRALDALRDHWPDAPATFGPQDV
                     EELRTRQLALRERLHQLPAPTARAQEGA"
     gene            8629..9960
                     /locus_tag="IE308_RS09610"
                     /old_locus_tag="GCM10018783_19730"
     CDS             8629..9960
                     /NRPS_PKS="Domain: Aminotran_3 (44-373). E-value: 2.8e-72.
                     Score: 235.5. Matches aSDomain:
                     nrpspksdomains_IE308_RS09610_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009085825.1"
                     /locus_tag="IE308_RS09610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19730"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_190217509.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2e-80, bitscore:
                     266.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQDLPDRPLDDRPLQDRPLHDRHRRVLPRWVTTYYEQPLHPVS
                     ATGRVVTDAHGRDHLDFFAGILTNSLGYDVADFRRALDRQLDTGIVHTSTLYLIDAQVR
                     LAERLAEQSGIDDAVVFFVNSGTEANDTALLAATCHTGSNHVIALTDSYHGRSLTSTAV
                     SGLPGWRPSPYSPFQVTFASNGRTSPSDDEHPPEDPAADLEAQLAGQAPPAALIVEPVQ
                     GLGGFHTPPTALLQRYARIAADHGAVLICDEVQTAWGRTGRAWWGHQLHRLKPDVITFA
                     KGIANGLPLGGVIARRDILDSVAGKSISTFGGNPLACTAALATLDHIHDHDLQRNAETA
                     GQSLLAQLRRLAADHPHLADARGQGLMLAVDIVDPRSGRPDPDAARAHVETCRAQGLLI
                     GLGGRHGNTLRIAPPLTVTRDEIEEATRILAAAARHHTPAPATA"
     aSDomain        8761..9747
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS09610_Aminotran_3.1"
                     /evalue="2.80E-72"
                     /label="IE308_RS09610_Aminotran_3.1"
                     /locus_tag="IE308_RS09610"
                     /protein_end="373"
                     /protein_start="44"
                     /score="235.5"
                     /tool="antismash"
                     /translation="SATGRVVTDAHGRDHLDFFAGILTNSLGYDVADFRRALDRQLDTG
                     IVHTSTLYLIDAQVRLAERLAEQSGIDDAVVFFVNSGTEANDTALLAATCHTGSNHVIA
                     LTDSYHGRSLTSTAVSGLPGWRPSPYSPFQVTFASNGRTSPSDDEHPPEDPAADLEAQL
                     AGQAPPAALIVEPVQGLGGFHTPPTALLQRYARIAADHGAVLICDEVQTAWGRTGRAWW
                     GHQLHRLKPDVITFAKGIANGLPLGGVIARRDILDSVAGKSISTFGGNPLACTAALATL
                     DHIHDHDLQRNAETAGQSLLAQLRRLAADHPHLADARGQGLMLAVDIV"
     gene            10001..11830
                     /gene="asnB"
                     /locus_tag="IE308_RS09615"
                     /old_locus_tag="GCM10018783_19740"
     CDS             10001..11830
                     /EC_number="6.3.5.4"
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="asnB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: tabtoxin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607724.1"
                     /locus_tag="IE308_RS09615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19740"
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="WP_190217510.1"
                     /sec_met_domain="tabtoxin (E-value: 1.1e-167, bitscore:
                     555.2, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 3.7e-46, bitscore:
                     152.2, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 4.9e-89, bitscore:
                     295.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIVGWTDFTRDLSQEHTTLQRMTGTMALRGPDAAGTWLGPHTA
                     LGHRRLSIIDLEGGTQPAVASTEPHQEPVVLVYSGEVYNFRELRAALETRGHRFTTRSD
                     TEVVLRSYLEWGAACVDHFNGMFAFAVWDARREELLLARDRIGIKPLYYFAYPGGILFA
                     SEPKGIMANPLFQPVVEEDSLPILFNARLALPGETPLRGLRELPPGHILRFSRSGSHEY
                     PYWRLVSREHRDDLTTTVTTVRDLLEDIVDRQLVADVPRSAMMSGGLDSTIMSALANRR
                     LNAAGEGPLHTFAVEFAGDEKDFKPTELRPERDAPYARLASRHLGTVHHNITLHTDDVL
                     AALPAARRARDLPSLGQFDTSMYLLFKAIREQSTVALSGEAADEVFGGYPWYHDERLVW
                     RDRFPWIGDAPRLADAFAPDLHRRVRPADAENDRYLTLKAEVPRLPGEQGLNARMREVM
                     YYSLKGPLAYLLDRKDRMSMAVGLEVRVPYCDHRLVEYVWNVPWEMKNADGRWKSLLRL
                     AFADVLPQETLDRPKSGYPGTHDPAYDAEVMRSIDKVLSDPSSPLHGVFDPQRVEGLTR
                     SGSKTMTWLNSSHLLLPILEVDAWMRAYNVSLA"
     misc_feature    10925..10927
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11992..12879
                     /locus_tag="IE308_RS09620"
                     /old_locus_tag="GCM10018783_19750"
     CDS             11992..12879
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-164). E-value:
                     9.3e-30. Score: 95.9. Matches aSDomain:
                     nrpspksdomains_IE308_RS09620_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122916.1"
                     /locus_tag="IE308_RS09620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19750"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190217511.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-23, bitscore: 80.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.3e-18, bitscore:
                     62.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFPDFTLETVDLGEVRLRVRHGGRGPAVLLVHGHPRTHTTWHRLA
                     PLLAEDHTVVCPDLRGYGQSSKPPTDDDHAPYSKRRMAADCLALMRSLGHETFHVVGHD
                     RGGYVATRLALDHPSAVTHLTTLDVVPIGEALARCDAEFATRWWHWFFRAQPSPGPETV
                     IGNNLSLWYPETPEDMGQENWDDFQHALSDPRTIHAMCEDYRAGLGIDRRHDDEDRAAG
                     RRVQCGTLVLWGTKSDLPLLYEDIAGIWRNWVAGELTAKGIDSDHHIAEEAPAELGEEL
                     RRAWAEAEAAGHGA"
     aSDomain        12067..12483
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS09620_Abhydrolase_1.1"
                     /evalue="9.30E-30"
                     /label="IE308_RS09620_Abhydrolase_1.1"
                     /locus_tag="IE308_RS09620"
                     /protein_end="164"
                     /protein_start="25"
                     /score="95.9"
                     /tool="antismash"
                     /translation="PAVLLVHGHPRTHTTWHRLAPLLAEDHTVVCPDLRGYGQSSKPPT
                     DDDHAPYSKRRMAADCLALMRSLGHETFHVVGHDRGGYVATRLALDHPSAVTHLTTLDV
                     VPIGEALARCDAEFATRWWHWFFRAQPSPGPETVI"
     gene            complement(12958..14286)
                     /locus_tag="IE308_RS09625"
                     /old_locus_tag="GCM10018783_19760"
     CDS             complement(12958..14286)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547856.1"
                     /locus_tag="IE308_RS09625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19760"
                     /product="hypothetical protein"
                     /protein_id="WP_190217512.1"
                     /transl_table=11
                     /translation="MFRRRAAWAAIGTVALLLAGAPAADAVEGQAPDVRWASSVSDDLG
                     TLAVSAGSDSAITEIRAHIVSAATQQEVAVVENDAFVLVSGTPQDGVWHTRQPLDLADL
                     GSYTVRVEAADADGDRTTDNSAGTLAYYVVPVFEDVRTDRAEVDIDHREVRVDGVLKGR
                     WPATRELKPLADHPVDLDVDYWTENTVRTDAEGHFSGTVTVNGAVPVQAVHRHNNAHPY
                     VLYGESASIQMGVRQVATRWTVQSPAEARTIDFGQQVTITATLERETPQGWVPFEGQSG
                     GVLFEPSSGGQFASVGYFTTGADGTVTFTHAPWETGTFRVASHSDDPFIAPASVNSARI
                     TVLRASVFTSFSATRTPDRGVHVEGAMDFPDGWTPATIPVHIQYSRDGKQWTDLLTTEA
                     TWSGSGHAFAADIADARHGYFRAHFEATDSFRAATSQSVRASR"
     misc_feature    14328..14346
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    14393..14402
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            complement(14445..15764)
                     /locus_tag="IE308_RS09630"
                     /old_locus_tag="GCM10018783_19770"
     CDS             complement(14445..15764)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.5"
                     /locus_tag="IE308_RS09630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19770"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_268256470.1"
                     /transl_table=11
                     /translation="MPAAAPAPPPQGTATLWVAPPAQPIPSPRVRAVETEDRPPLTIDV
                     DAERRLWTLSAPPGVPSRPVVTGGTVYLFLADGRLAAVDPDRGRVLWCSAPLTQPDTAR
                     LVSVGEVVVIAVQRESGRCGYVALDAATGTVRWTRIKSDLHRVAVAGSTLVLWNDTYDE
                     RAKIAGVDALTGELLWQNEFERIWRLLVRGERVILDTGGLRALDARSGEELWRKGHGNP
                     LPGQQGTDDAAVFHAWKDGTEPELSLCASDTGEQLAATRFPRRAMRHFSEPPILLDGGR
                     ALFAKSYGRRIQVYAHSGLAAAEPLLELRLARWRFTYFSEGPVCVGDWLYAVGGRRHHV
                     YAAECGGGSGPRALPVTAPNGRAVTWPRTIAGPSHVFLSDGRTVAAVREGRVLWTTATD
                     VFDSWPVPLGPDRVLFSSRSRTGDGYLLHCADAETGRRHT"
     gene            complement(15828..16652)
                     /locus_tag="IE308_RS09635"
                     /old_locus_tag="GCM10018783_19780"
     CDS             complement(15828..16652)
                     /EC_number="3.1.-.-"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014178958.1"
                     /locus_tag="IE308_RS09635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19780"
                     /product="dienelactone hydrolase family protein"
                     /protein_id="WP_229908796.1"
                     /transl_table=11
                     /translation="MTIMRGQSDPLDDFSRRAVSVDDVDKTVYVTGSGPAVILMPEMPG
                     ISPDVARFARWVRDAGFSVYLPSLFGVDGAYPLAEAGEAVVRRACVSAEFRAFAGGGTS
                     PVVTWLRGLARLAHAERGGPGVGAVGLCFTGNFALTMALEPAVIAPVVNHPSLPLDDPG
                     GLEISDEDAAAVAERVAREGLKVLAYRFDNDRWCTGQRFAAYRALLGDAFDGRVLKAEA
                     ANTDPPPFFRDVVGCAHSVVTAHLVDQDGHPTMQARDEIIAFLAERLVMSAE"
     gene            16779..17789
                     /locus_tag="IE308_RS09640"
                     /old_locus_tag="GCM10018783_19790"
     CDS             16779..17789
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891605.1"
                     /locus_tag="IE308_RS09640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19790"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_190217514.1"
                     /transl_table=11
                     /translation="MSPLRVGVLAYPGCFASEVFGVPDLLAMASHVAAAQGAVQPAYET
                     SVISPRRRVIAAGGSVLDVAAVRPVDVLIVPGFELSPTLDLNATLAHLKPEAASIRSQA
                     ASGAAVVSICVGAFLVAEAGLLDGRQATTSWLFADRFARRYADVRLRPESLVVTDRGVT
                     TTAAFSAMYDFALQLIREHDGPRVARSTARIALVDDARSTQAPYVDPDLIPTVGREFSL
                     SVKRWLDQNLTARYDLPALAQEFHVSTRTLLRRFRDEAGETPLAYLQTVRVRRARHLLE
                     TTDRTVASIAADVGYGDPGTFSSVFARHTGQRPREYRAIFRRRRDPHGSIRRTET"
     gene            complement(17815..19191)
                     /locus_tag="IE308_RS09645"
                     /old_locus_tag="GCM10018783_19800"
     CDS             complement(17815..19191)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018471371.1"
                     /locus_tag="IE308_RS09645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19800"
                     /product="S41 family peptidase"
                     /protein_id="WP_190217515.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 8.1e-27, bitscore:
                     89.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIVTATAAALALAGQAVPAATAHHPTADGIWRMDGYGTVLSIRN
                     GTFQEYQTTTVSCLKGDSAERSGPGTYTMPDGTVLTVRVQGGGDRGSLRVDGSVGDRNL
                     HRIPELPDACTRPAPEGPLAAFDVFWQSFEENYPFFAAKGIDWHAVRDRYRPRVHAGTT
                     RDELYAVFSEMVKPLHDAHVAVQDGDRVFAQVRPGTAVPTEELDTKVKQFVVARDLKNA
                     RNLQDFANGRITYADLPGAQGYVRISGFGGYAGHGASYAAQLAELDRALDTVLSRERTQ
                     RLKGLIIDVRINGGGSDALGVHIAERLTDTAYLAYSKRARNDPADPSRHTRPQPVYVTP
                     AQGPRYTGPVAVLTGGSTFSAGETFTQALMYRPGKTVRIGRPTQGVFSDVMSRTLPNGM
                     SAWLPNEEFLTRSGRTFDGTGIPPHLTEPVFTKEEFDKQRDSAFDRALDVLRNSDGTTS
                     "
     gene            complement(19486..20091)
                     /locus_tag="IE308_RS09650"
                     /old_locus_tag="GCM10018783_19810"
     CDS             complement(19486..20091)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010232182.1"
                     /locus_tag="IE308_RS09650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_19810"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_190217516.1"
                     /transl_table=11
                     /translation="MSELLVDFITSLDGYASGRGWPGFWGLEGPEYLAWLGEQPEATYL
                     MGANTYRLMSGFAAGEVPEGQDEFRPEEEESVDQLTQAPKVVFSSSLEEPLTWANSTLV
                     RDDAVETVRAMKSSGSGLLSTIGSLSLCRSLLRAGLVDRFRVVMFPVITGATGEERIYD
                     GYPDVALEMIDHRTFDGRIQLVEYKPRVLEHPPLGAPE"
     misc_feature    complement(20512..20526)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.63"
                     /tool="antismash"
ORIGIN
        1 gtgctgggct ggttcctcac cagtaccggc atggacccgg acgacgccgc gcgagcggtg
       61 gagcgggcga tcggcggccg gttgtcacga ggacgcgcag gcgccatctc cccggtgggg
      121 cgcgaaccct gagcgtgtca ccacggcacc tctccctcgt cgtcgaagaa gcggcccgtc
      181 ggcccgtcgg ccgatacggt ggccagccgg atcgcgatgg ctgcgccctg ccggggggtg
      241 cgcactccgc ggaagccgtt gaggtcggtc gccgtgtagc cggggcagac ggcgttgatc
      301 aggatgttgg tgtcggccag ttccctggcg tactgcacgg tgacggcgtt gaggaacgtc
      361 ttcgacggag cgtaggcgac ggcgatgggg ccggtctcgg cgcccggcgt ggattggcgt
      421 gtgagggagc cgacgctgct ggagacgttc acgatcctgg gcgcaggcga gcggcgcagc
      481 agcgggagca gggcgttggt gacgcggatg acgccgatca cgttggtctc cactgccgcg
      541 cgtacccggt tcacgtcgac cgtggtgggc tcctgcggcc cgccgccggt gatccccgcg
      601 ttgttgacga gcgcgtcgag ccgcccggcc cgctcctcga tcagccgggc cgccgctgtc
      661 acgctggcgt cgtcggtcac atccagcggc acgccgaacg cgtcggctcc ggccgcgcgc
      721 agcttgtcca cggcggcctc gcgccgctcc tcgttccgcg cgccgatgcc gacggaccag
      781 ccgagggctc cgagcccggc ggcgatctcg tacccgatgc ccttgttggc cccggtcacc
      841 agcgcgacct tggggtggtt cacggtgttc gtctcactca tggcatcgat ccttctcccc
      901 cgccgggcga ggcgtccaag accgactggg tggacggcga taccgcccgg gtatcggtgc
      961 tggtcgcgcc agttaggctg gcggggtgga gacacgtgag ctgcggtact tcgtcgcggt
     1021 cgccgaagag ctgcacttcg gtcgggccgc acagcggctc gggatcgccc agccaccgct
     1081 gtcgcgggcc gtcgccggac tcgaacggcg cctgggcacc ctcctgctgg agcgaagcag
     1141 ccggggtgtc accctcaccg gggcaggggc ggtgctgctg cgggaagcgc gggctgcgct
     1201 ggacgccgtc gaggccgccg aacggcgcac ccgccgggcc gccctcgcgg cgaccggcca
     1261 cccgaccgtg gtcctcgccg cgaaagcggg cgcctccggt gaactgctgg ccaaactcct
     1321 cgacgcctat gccgccgagc ccggcgccgt cgccgtggac gtcgtgttgt gcgggccggg
     1381 cgagcaggca cggttgctgc acgacggccg ggccgacgta gcgctgctgc accggccgtt
     1441 cgacgacacg gccggcttcg acaccgaaga cctgcacacc gagggtcagg tcgcgatcct
     1501 cccggcggcc cacccgctca gcgcccgccc ccacctgcgg ctggccgagg tcaccgacct
     1561 acccgacctg cccctgcccc gctggcccca ccccgacggc accttcccgg acggccccgg
     1621 accgcaggta cgcgaccaca cccaactcac ccagctcatc gccctcggcc gcgcctgcgc
     1681 ggtcgtgccg gagtcaggca gcaccggact gcgcgagggc ctgaccgccg taccggtccc
     1741 cgacgccccc cacgtcacca ccgtcatcgc ctggccccca cacagccact cgacagcggt
     1801 cgcggcactg gtccgcgccg ccaccgacct gtgaccgacg gcggagacca ctggggaaac
     1861 ctgccgcgca cgccgtgcca tcgaccggga ccgcgatcgt acgcaagtag ccatacgccc
     1921 cgcggcgaaa gctgcttagc cctggggatg agaaacccgc tccggctctg aactcccctt
     1981 caccgagcgg gagcctgcgc gccgcaccgc agatcggcac agaggcgcga ccggcaggga
     2041 gcaggtgagg aggatcagtg cgaggatgcc ccaacccgcc cctccggcgc cgctgatcag
     2101 cgtgacgacc agcgcgggtc cgatggccac cacggcgcct tccgtggtgg ccgcgacggc
     2161 ttggtactgg ccttgggcgc cgtgtgccat gagcttgatg gacagtcccc aacgggctgc
     2221 cacgtagtac agctccccca ggacgtgcag ggccagtccg gcgaggacga cgacggcggc
     2281 cacggccggg ccggcgggcc aggcggctgc ggcgaagacc aggcagcatg cggcgagcgc
     2341 gacactggcg cgccatgagg agcgtacggc tccggccaga cgttgcccgg ttcgggtgac
     2401 gcgcacctgg aagagcgcga tcaggaggga gctggccagt accgacaggg gggcgatcca
     2461 taccggtgcc gtggtgtcct ccttcagcca caggggcagg ccgctcgaca ggagcgccca
     2521 gcacagggcc agcagtgcgg tactgctcat gatcgccgtg aaggggatgt tgcggagtgc
     2581 ctctgtgctg aggtgccgcc gcgcggcggg cgccggcggg acgtgcggga ggcgggccag
     2641 cagcgcggcc gagacgacga aggtgaggct gttgaccact acggcgccgt ggtagggggc
     2701 agccgactgg cgggagagca cccaggcggc ggcgcccgcg ccggcggcgt agaggatgtg
     2761 ctggacgacg cgggcccggg cgaggacggg caaacagtcc cgttctggca ccagcaggtg
     2821 gacgagcgcc accttgctgc ccttggcggc cgtctccatc gaggtgaaca gggcggcagc
     2881 gaccaggagc ggccagaagg tgtgcgtggc caggaaggtg agcgagaagg cggcgcgcag
     2941 gacagtgacg gccacgaggg tctcgcgtgc gccgagacgg tccgtcagcg tgccgacggg
     3001 cagggcggcc aggaggccga gcccccctcc gagccccatc gcgagaccca tcgtcgcggc
     3061 ggggacgccc tgaacggcgg tcaggtagac cgcccacatg ctgaaccaga gtccgtctcc
     3121 cacggcggtc gtgccttcgc tgagcagcag ccggcggacg actaagcgat ctttcgactc
     3181 tttttcggcc ctagtgtggc tcaattctcg ccttccctta ccgtcgcggc gctctgggga
     3241 cccgcggccg cttcgaaact cacttcagga caccgtccgg aggagcgcca tttcagccat
     3301 cctctgcctt gaaaccacgc cctccggcgt gactctgcgg attcggacac aggtggtcag
     3361 tcgtgggtac ccgacgcccc ttcgagcaaa cagaattact ttaagcagac atcaacgccc
     3421 gtctggaaaa ctccatgagc agcggttact acacgctgtg actcgactgc cggcggtgca
     3481 tgcatacgga acgttaaata cttgcggcgc ttgacacgcg tccgcccgct ccggatatcg
     3541 tgacgacgcg tcaccggtta tttcaactgg gcccccggtc tttgaggccc ccccgcttcg
     3601 ccatgcattc cacgatgccc gtgctcaatt caccgccacc tgctctgaaa cgcatgggcg
     3661 catacttccg cctgctttcg tcggaggaaa agaaatggcg cactcacctc tcagcattct
     3721 ctcccaggtc gatttcaacg gcgatccgtt gaccgacgag ctgctgatga agacgttcca
     3781 ccagctcatg gacgagcacg gctacgtcct gatgtgcaac gtgccggagg aattcgaccc
     3841 ggtcaggttc tgccggaacc tgggccgctt cgtgcccaac tacaccggcg cggttgtcgg
     3901 tgacgtacgt cctgagcccg gtatggacga cgtctaccac gcgggcaaca cccgcccgct
     3961 gaccccgcac tccgagggat acgacttcgc cgtcgtcccc ccgcgctaca tcgcgctgtg
     4021 gtgcgtcaca ccggccggcg ggccgggcgg cgagaccacg ctcgccgaca ccaggccctg
     4081 ggtcgagtcc ttcacggcgg aggaacgcga gtggttcctc acgcacgagt acgactggaa
     4141 gaccaccgaa ggcgtgcagc gcctggggct cgacctgaag acccgccacc ccgtcctcga
     4201 agagaccgac cagggcacga tcgtccgctt cagctgcaac aacctgatac gggacgacgg
     4261 cgatccggcc gccgagctgc agcagcgctg gcacgcggcg ttcgaccgcg agcacgtgtc
     4321 catcgactac tccgagaagg acatgctcgt gtgggacaac tggcggctgc tgcacgcccg
     4381 taacgccttc agcgaccgca accggcacct gcgccgcatc cagatcgccg cctgaccccc
     4441 ggacagtgag gaagcacccg catgtaccgc accatgctgc acagcaagat ccacagggcc
     4501 accgtgaccc aggccgacct gcactacgtc ggctccctga ccctggaccg cgacctgatg
     4561 gacgccgctg acctgctgcc gggcgagaaa gtcgacatcg tcgacatcaa caacggcaac
     4621 cggctgagca cctacgtcat cgagggcgag cgcggcagcg gcgtcgtcgg catcaacggc
     4681 gcggcggccc ggctgatctc gcccggcgac ctggtgatcg tcatcgccta ccagagcgtt
     4741 tccgcggccg aggcgaggga cttacagccg aacatcgtct tcgtcgacca gcacaaccgc
     4801 cccctggaca tcggcggcga cccggcccac gtacccgccg accccgccgc cgcctcattg
     4861 atgcgcggcg acacgctcgc ccatggagcg gtgcgatgac caccgtctcc cccgccccgg
     4921 ccaccgccct ggcgccggcc ggccccggca ccgtctgccg cgccctcctg cggtactacg
     4981 acgacctctc ccgcgtcctc gcggacaccg gcagccggga ccggacggcc ggcttctccc
     5041 ccgggtggcg gctgccggcc cccggtccgg ccctggagcg gttcttcgaa ccgggcggca
     5101 tcagcgccca ggacctgggc agctaccacg acaccccgct gcggttcctg aacctgatgc
     5161 acaacccgag gacccgcacc accaagacgc tggcgtccct gctgatcgtg gcccgcgcgg
     5221 tcgaccacat ccagcgcacc ggcgagtccg tcctgatcat cacgccgtcc agcgcgaaca
     5281 aggcgaccgc tctgcgcgac gccgtactgc gggctcacga gaccggtctg gtcggcgccg
     5341 accagctccg gatcgtctgt gtcgtgcccg ccgcctccag ccacaagctg tggcgctcgc
     5401 ccctgaccga cgacgacgtc ttacgcgccc gcaacccgct cgccgtcctc gacgcctccc
     5461 aaccgctcca cgtcaaggaa ctcgcgcgcg cactggccga ccgggaggcc gacgccctct
     5521 tcgcccggta cggcgtccgg ctctggcaca ccatggatct gagcaactac gcggtcgcgg
     5581 acaccgcgcg ggccctgttc gagcgcgacc acctcccggc cgcgccgcgt gtgcacgccc
     5641 attccgtctc cagcgctttc ggactgctcg gtcacttcta cggccagcag cagcacaccg
     5701 gccgcgactg gcccggcacg ggagcccgtt acttcctggt gcagcacctg ggcacgcccg
     5761 acatggtctc cagctactac cacggcaggt tcgactaccg gccgcagtgg cagtaccgcg
     5821 acggcctgca cgtccaggac tccgaccccc ggttccccgg ccggaccttc gcgcccgacg
     5881 agcaactgga caccaccttc tacacccgga ctcccgccac gtcggaacgg atgaacgaga
     5941 tcatccgccg tcagggaggc ggaggcatcg tcgtctcgct cgccgagtgc ctcgaccgct
     6001 acccgctcgt ccgcgacctg ctgcaaccgg ccggcgtcga actgcctgcc gacccccggc
     6061 agatccgcga gtggtccctc gtgatggcgg tgaccggcgt cctcaacgcc ctggaccgcg
     6121 gactgctcga cgagacggag atcctggtcc acgggtccgg ctcctaccac gcggacgact
     6181 accgggcgcc gcaggcagac cagttgcgtc cgatcaccgg gtacggggac ctgcgggacc
     6241 tcgtgcacac agcggcagtc agctgaggac gagcacccat gacgacgcag gaccacaccc
     6301 tgcccaccgc ggcggccccg ccctccccca ccccggcagg ggtgggcggc gggggccgcc
     6361 cggcgcggca ccatcccctc gccccggtca gggcgcgcat cgcctactgg tggaacaaca
     6421 ccccggctcc cggctggcgc gccgtccgca gcaggaccga cagcctcccg cgcagcgtgc
     6481 ccgtcctgtc ctccctcacc ggccaggacg gtccgagcat cggctacgcc gggcttccgg
     6541 tgggccgtac gaacatcctc cagctcctcg aacaccagcg aacccagctc ggctgggcga
     6601 ccgtccggcg cacggacagc accctccgct ggggcgacct ggccgcgggc gactggcccg
     6661 acaccgacct cgtcgtggtc ggggccgagg agcgcgtact gcggcacctg cccgaacagg
     6721 gcagcgtgac ggcgccgttc cgcctccacc tggtggtgga cgtcccgccc tcacaggagg
     6781 agttggcgcg gctgatctcc aaacgggaac gctggcagtt ccgccgcgac cagcgcgagc
     6841 accagtgggt gctggaggag gactcctcgc ccgaggcact caccttcttc tacaaccgca
     6901 tgcacggccc caccatgcgc aaccggcacg gcgaccgcag ccgtaccgag cctctcgacg
     6961 tggcacgcta cgccgtgctg cgccggggca ccctgttctt cctcagccag gcgggcaccc
     7021 gcgttgccgg ggtgctgtgc cactggtcca aggaccggcg caccctcacc acccggctcc
     7081 tgggcgtact cgacggcctc gacgagcact accgcaccgg cgcgttcaag gcgctctacc
     7141 accatctgct gcgctgggcc tgcgagcagc gtgtcgcgcg cgtggacctg ttcggcaccg
     7201 aggcgtacat cagcaagggc atcttccagt ggaagcgcag gctgggcgcc cacccggagt
     7261 ggcccgccaa ccacttcgcc accaaacgcg tccggatcta cccgcgccgg gacacccccg
     7321 ccgtccgcga cttcctcgtg gcgaacccgc tggtgcgcac ggacgcccgg ggcgggctga
     7381 cgccggtgta ctacaccgac gacgaccgcc cgccccgcct cgacctcagc gcccggtgcc
     7441 ccgggctcgc cgagcccgag gtcgtccatc tcgacaccgt gctgcagccc gtcgccctgc
     7501 acgagccgtc gaggggaggc cgacggtgaa ccgctcccgt cacgtcgtcg tcctcggcac
     7561 cggtgccttc gcccgcgcgc tggtcaaagc cttcgcccag cgagccggcg ggccgaccgt
     7621 cgtccacatc gtcagcggcg accacgaccg cgcccggcac ctcgccggcc tcgccaacgc
     7681 ccacgccgcc ctggcggacc gtcccgtgcg ctgctgcccg caccggctgg acgtgccgga
     7741 cggagccgac ctgcgccccc tgctcggccg ccaccagccg gacgtcctgg cggtgtgcgc
     7801 ctcggagtac tcgcccgccg agacccgcgg gacgaagacc gcgtgggccg aactcatccg
     7861 cgcggcggga ttcggcgtca cgctgccgct gcaggcggcg accgcactgc gcgccgcgtc
     7921 cgccgcggcc gaggccagcc cccgcacggc cgtgctgaac gcctgcttcc ccgacgccgt
     7981 caatcccgtc ctgcacggtg ccgggctgcc cgtcctgtgc gggctgggca acgtctccac
     8041 gctcgtcagc ctcatccgca gcgagctgcg gatcggcgac gagtcacggc tgaaggtcct
     8101 cgcccaccac gcccacctgc acgctcctcc gacgcccgac caggaggtgc gggcctggct
     8161 cgacgaacag cccctgaccg ccgtacacga catcctccgg cgagagcgcc gccggccgcg
     8221 cgcggatctc aacgagatcg gcgcgaccgc cggcgcggcg gtgctggacg ccctgacgca
     8281 tccgcgtgac tacttcgccg ggcacgcagc cgccccccag ggcaggccgg gcgggtaccc
     8341 cgtcgtcatc accgggcgca gcatcgcgct gcgactgccg ccaggcatgt cggaacgcca
     8401 ggccgtcgcc cgcaaccagg agtggtccgc cctcgacggc atcacggtcg accagcaggg
     8461 caaggctcac ttcaccccta gggcgctgga cgcgctgcgc gaccactggc ccgacgcccc
     8521 ggccaccttc gggccgcagg acgtggagga actgcgtacc cggcagctcg ccctgcgcga
     8581 gcgactgcac cagctgcccg caccgaccgc ccgagcccag gagggcgcat gacctcccag
     8641 gatcttcccg accgccctct cgacgaccgc cctctccaag accgccctct ccacgaccgc
     8701 catcgccgcg tcctgccccg ctgggtcacc acctactacg agcagccgct gcaccccgtg
     8761 tccgccaccg gacgcgtcgt caccgacgcc cacggccgcg accatctcga cttcttcgcc
     8821 ggcatcctca ccaactcgct cggctacgac gtcgctgatt tccgccgcgc cctggaccgc
     8881 cagctcgaca ccggcatcgt ccacacctcc accctgtatc tcatcgacgc ccaggtacgg
     8941 ctggccgaac gcctcgccga gcagtccggc atcgacgacg cggtggtctt cttcgtcaac
     9001 tcgggcacgg aggccaacga caccgctctg ctggccgcca cctgccacac cggcagcaac
     9061 cacgtcatcg ccctcaccga cagctaccac ggccggtcgc tcaccagcac cgcggtgtcc
     9121 gggctgccgg gctggcggcc gagtccgtac tcaccgttcc aggtcacctt cgcctccaac
     9181 ggcaggacct cgcccagcga tgacgagcac ccgcccgagg atcccgcggc cgatctggag
     9241 gctcagctcg ccggccaagc accgcccgcc gccctcatcg tggaacccgt gcagggcctc
     9301 ggcggcttcc acacaccgcc caccgcgctg ctccagcggt acgcgcgcat cgccgccgac
     9361 cacggagcgg tcctcatctg cgacgaggtg cagaccgcct ggggacgcac cggccgcgcc
     9421 tggtggggcc atcaactcca ccggctgaag cccgatgtga tcacgttcgc caaggggata
     9481 gccaacggtc tgccgctcgg cggcgtgatc gcccgccggg acatcctgga cagcgtcgcg
     9541 ggcaagtcca tctccacctt cggcggcaac ccgctggcct gcaccgccgc actggccacc
     9601 ctcgaccaca tccacgacca cgacctgcag cgcaatgcgg agacggccgg gcagagtctc
     9661 ctggcacagc tgcgccgcct cgccgcggat catccgcacc tggcggacgc ccgcggtcag
     9721 gggctgatgc tggccgtgga catcgtcgac ccgcgaagcg gacggcccga ccccgacgcg
     9781 gcccgcgccc acgtcgagac gtgccgcgcc cagggcctcc tcatcggcct cggcggacgc
     9841 cacggcaaca ccctgcggat cgccccgccg ctgaccgtca cccgggacga gatcgaggaa
     9901 gccacccgca tcctcgccgc agccgcgcgg caccacaccc ccgcaccggc aaccgcctga
     9961 caccgtcggc cccgctccag cagtcccaga aaggacatcc atgtgcggca tcgtcggatg
    10021 gaccgacttc acccgcgacc tcagccagga gcacacgacg ctccagcgca tgaccggcac
    10081 catggccctg cggggccctg acgccgccgg cacctggctc ggcccccaca ccgctctcgg
    10141 tcaccgccgc ctctccatca tcgacctgga gggcggcaca caaccggccg tcgcctcgac
    10201 cgaaccccac caggagcccg tcgtcctcgt ctacagcggt gaggtctaca acttccgaga
    10261 actgcgcgct gccctcgaaa cacgcgggca ccggttcacc acccgctccg acaccgaggt
    10321 cgtcctgcgc tcctacctcg aatggggcgc ggcctgcgtc gaccacttca acgggatgtt
    10381 cgccttcgcc gtctgggacg cccggcgcga ggaactcctc ctggcccgcg accgcatcgg
    10441 catcaagccc ttgtactact tcgcctaccc cggcggcatc ctcttcgcct ccgaacccaa
    10501 ggggatcatg gcgaaccccc tcttccagcc ggtcgtggag gaggacagcc tgcccatcct
    10561 gttcaacgcc cgtctggccc tccccggcga gacaccgctg cgcggcctgc gcgagctccc
    10621 tccgggccac atcctgcgct tctcacgcag cggcagccac gagtacccgt actggcgcct
    10681 ggtcagccgc gaacaccgcg acgacctgac caccaccgtg acgaccgtcc gggaccttct
    10741 cgaggacatc gtcgaccgcc agctcgtcgc cgacgtcccg cgctccgcga tgatgtcggg
    10801 agggctggac tccaccatca tgtccgccct ggccaaccgc cgtctgaacg cggccggcga
    10861 aggccccctg cacaccttcg ccgtcgaatt cgccggtgac gagaaggact tcaagccgac
    10921 cgagttacga cccgaacggg acgcccccta cgcccggctc gcctcccgcc acctgggcac
    10981 cgtgcaccac aacatcaccc tgcacaccga cgacgtcctc gcggccctgc ccgccgcccg
    11041 gcgagcacgc gacctgccgt ccctggggca gttcgacacc tcgatgtacc tgctgttcaa
    11101 ggcgatccgg gaacagtcca cggtggcgct gtccggagag gcggccgacg aggtcttcgg
    11161 aggctacccc tggtaccacg acgagcggct cgtgtggcgc gaccggttcc cgtggatcgg
    11221 tgacgccccg cgcctggccg acgccttcgc tcccgatctg caccggcgcg tccgtccggc
    11281 cgacgcggag aacgaccgct acctcaccct caaggcggaa gtcccccgcc tgcccgggga
    11341 gcaggggctg aacgcccgta tgcgcgaggt catgtactac agcctgaaag gccccctcgc
    11401 ctacctcctc gaccgcaagg accgtatgag catggcggtg ggcctggagg tacgtgtccc
    11461 gtactgcgat caccggctgg tcgagtacgt gtggaacgtg ccgtgggaga tgaagaacgc
    11521 cgacggccgc tggaagagcc tgctgcggct cgccttcgcc gacgtcctcc cgcaggagac
    11581 cctggaccgg cccaagagcg gataccccgg cacccacgac ccggcctacg acgcggaggt
    11641 catgcgctcc atcgacaagg tgctcagcga tccctcctcc cccttgcacg gcgtgttcga
    11701 tccgcagcgc gtggaggggc tcacccggtc ggggtcgaag accatgacgt ggctcaactc
    11761 cagccacctc cttcttccca tcctggaagt ggacgcctgg atgcgggcgt acaacgtgtc
    11821 cctcgcctga ccgtgccacg gcaccagggc cggcagcggc cttccgtcct cctcccgtac
    11881 acccgtccgg cggctcagcg gcgggccgga cgggtgtacc ggaggagcgg aacagccgta
    11941 ccggccggtg gccgggagtt cgcccctcgc aatcaaggga agaggtggtt cgtgtttccc
    12001 gacttcacac tcgagaccgt cgacctcggc gaggtccgcc tgcgcgtgcg ccacggcggg
    12061 cgcggaccgg ccgtgctcct cgtacacgga cacccgcgca cccacaccac atggcaccgg
    12121 ctggccccgc tgctcgccga ggaccacacg gtcgtctgtc ccgacctgcg cgggtacggc
    12181 cagtcctcca aaccccccac cgacgacgac cacgcgccct actccaagcg ccggatggcc
    12241 gcggactgcc tggcgctcat gcggtccctg ggccacgaga cgttccatgt cgtcggacac
    12301 gaccgaggcg gctacgtcgc cacccgcctg gccctggacc acccgtcggc tgtcacgcac
    12361 ctgaccacac tggacgtcgt ccccatcggc gaggccctcg cacgctgcga cgccgaattc
    12421 gccacccggt ggtggcactg gttcttccgg gcccagccca gtcccggacc ggagaccgtc
    12481 atcggcaaca acctcagcct gtggtatccg gaaacccccg aggacatggg ccaggagaac
    12541 tgggacgact tccagcacgc gctcagcgat ccgcggacca tccacgccat gtgcgaggac
    12601 taccgggccg gactcggcat cgaccgccgc cacgacgacg aggaccgggc ggccggacga
    12661 cgcgtgcaat gcggcaccct cgtgctgtgg ggcacgaaga gcgatctccc cctgctgtac
    12721 gaggacatcg ccggcatctg gcggaactgg gtcgcgggcg aactgacggc gaagggcatc
    12781 gacagcgacc accacatcgc cgaggaggct cccgcggaac tgggcgagga actgcgcagg
    12841 gcttgggcgg aggccgaggc ggcaggtcac ggcgcttgac ctcgcaccca cggccccttt
    12901 ttgacgggcg ctgtgcgagc gggcccggcc ggtccctacc ttgtgtatcg ccggaggtca
    12961 gcggctcgcc cgcacggact gcgaagtcgc cgcgcggaac gagtcggtcg cctcgaagtg
    13021 cgcgcggaag tagccgtgcc gtgcatcggc gatgtccgcc gcgaaggcgt ggccactgcc
    13081 ggaccaggtg gcctcggtcg tgagcagatc ggtccactgc ttgccgtcac gcgagtactg
    13141 gatgtgcacc gggatggtgg cgggcgtcca gccgtcgggg aagtccatcg caccctcgac
    13201 gtgcacgccg cggtccggcg tgcgggtggc cgagaacgag gtgaagacgg aggcgcgcag
    13261 cacggtgatc cgggcgctgt tcacggatgc gggggcgatg aacgggtcgt cgctgtgcga
    13321 cgccacgcgg aaggtgccgg tctcccacgg ggcgtgggtg aaggtgaccg tgccgtccgc
    13381 acccgtggtg aagtagccga cggaggcgaa ctggcctccg gaggacggct cgaagagcac
    13441 gccaccgctc tgcccctcga aggggaccca gccctgtggg gtctcccgct ccagcgtggc
    13501 ggtgatcgtg acctgctgtc cgaagtcgat cgtccgggcc tctgcggggc tctggacggt
    13561 ccagcgggtg gccacctgcc ggacgcccat ctggatggac gcggactctc cgtacagcac
    13621 gtaggggtgc gcgttgttgt gccggtgcac ggcctggacc ggcaccgcgc cgttgacggt
    13681 gaccgtgccg gagaagtgtc cctcggcgtc ggtgcggacg gtgttctccg tccagtagtc
    13741 cacatcgagg tcgaccgggt ggtccgccag gggcttcagc tcgcgggtcg ccggccaccg
    13801 gcccttgagg acgccgtcga cgcgcacctc acggtggtcg atgtccactt ccgcgcggtc
    13861 ggtccgtacg tcctcgaaca ccggcacgac gtagtaggcg agggtgcccg cggagttgtc
    13921 ggtggtgcgg tcgccgtcgg cgtccgcggc ctcgacgcgg acggtgtagc tgcccagatc
    13981 ggcgaggtcc agcggctgcc tggtgtgcca cacgccgtcc tgtggcgtgc cggagacgag
    14041 gacgaacgcg tcgttctcga cgacggcgac ctcctgctgt gtggcggctg agacgatatg
    14101 cgccctgatc tccgtgatcg cgctgtcgga gccggcgctg acggcgagag ttccgaggtc
    14161 gtcggagacg ctgctcgccc accggacgtc gggagcctgc ccctccacgg cgtccgccgc
    14221 cggagcaccg gccaggagca gcgcgacggt accgatggcg gcccaagccg cccgtcttct
    14281 gaacacaagt ccccccagaa ttggtcgaga gcgcaaccgc aactccgtac gtgtctacgg
    14341 tgtgcgctga gtctgaaggg ctttctaccg cacgggaccg acatcggccc catgagtttt
    14401 gaccaccggg ccggacaaag caggggaagc ggacggaagc gcggtcaggt gtgacggcgg
    14461 ccggtctccg cgtccgcgca gtgcagcagg tacccgtccc cggtccggct gcgcgaggag
    14521 aacagcacgc ggtcggggcc gaggggcacc ggccagctgt cgaacacgtc cgtggccgtc
    14581 gtccacagca cccgcccctc ccggaccgcg gcgacggtcc ggccgtcgga gaggaagacg
    14641 tggctcgggc cggcgatcgt ccgcggccac gtcaccgccc ggccgttcgg cgcggtcacc
    14701 ggcagtgccc gcgggccgga cccgccaccg cactcggcgg cgtacacatg gtggcggcga
    14761 ccgccgacgg cgtacagcca gtcgccgacg cagaccggac cctcggagaa gtacgtgaag
    14821 cgccagcgag cgagccgcag ttccagcagg ggctctgccg cggccaggcc ggagtgggcg
    14881 tagacctgga tgcgccggcc gtaactcttc gcgaacaggg cccggccgcc gtcgagcagg
    14941 atgggcggct cggagaagtg ccgcatcgcc cgccgcggga agcgggtggc ggcgagctgt
    15001 tcaccggtgt ccgaggcaca cagggacagt tcgggctcgg tgccgtcctt ccatgcgtgg
    15061 aagaccgccg cgtcgtccgt cccctgctgt ccgggaaggg ggttgccgtg gcccttgcgc
    15121 cacagctcct caccactgcg ggcgtccagc gcacggaggc ccccggtgtc gaggatcacc
    15181 cgctccccgc gcaccagcag gcgccagatc cgctcgaact cgttctgcca caggagttcg
    15241 ccggtcagcg cgtcgacccc ggcgatcttc gcacgctcgt cgtaggtgtc gttccacagc
    15301 accagcgtcg aaccggcgac cgctacgcgg tgcagatcac tcttgatacg cgtccaccgc
    15361 accgtgccgg tcgcggcgtc cagggccacg tacccacagc gcccgctctc cctctgtacg
    15421 gcgatcacga cgacctcgcc cacggacacc aggcgtgcgg tgtccggctg ggtgagcggc
    15481 gcgctgcacc acagcacgcg gccgcggtcc gggtcgacgg cggcgagacg gccgtccgcc
    15541 aggaacaggt agacggtgcc gccggtcacg accggccggc tcggcacgcc gggcggcgcg
    15601 ctgagcgtcc acaggcggcg ctccgcgtcg acgtcgatcg tcaagggcgg tctgtcttcg
    15661 gtttccacgg cacgtactct cgggctcggg atgggctggg cgggcggggc gacccagagc
    15721 gtagcggtgc cctgcggcgg cggggcaggg gcggccgcag gcatcggggt aacacccaga
    15781 caggacggcc gggacgggcc cgaactccta cccggagcgt caagggctca ctcagcgctc
    15841 atgacgagcc gctcggccag gaaggcgatg atctcgtccc gggcctgcat cgtgggatga
    15901 ccgtcctggt cgaccaggtg tgccgtgacc acgctgtggg cgcagccgac gacgtcacgg
    15961 aagaagggcg gagggtccgt gttcgctgcc tcggccttga ggacgcggcc gtcgaaggcg
    16021 tccccgagca gcgcccggta agccgcgaac cgctgaccag tgcaccacct gtcgttgtcg
    16081 aagcggtagg cgagaacctt caatccctct cgcgccacgc gttcagcaac ggcggcagcg
    16141 tcttcgtcgc tgatctccag accgccggga tcgtcgagcg gcagcgacgg atggttgacc
    16201 actggtgcga tgacagccgg ttcgagcgcc atggtcaggg cgaagttgcc agtgaaacac
    16261 agaccgacgg cgccgacgcc aggcccgcca cgctcggcgt gcgccaggcg ggcgaggccg
    16321 cgcagccatg tgacgacggg gctggtgccg ccaccggcga acgcccggaa ctcggcgctg
    16381 acgcaggcgc gtcgaacgac agcttcgcct gcctcggcga gcggataggc gccgtcgacg
    16441 ccgaaaagag agggcaggta cacggagaag ccggcatcac gcacccaccg cgcgaaccgc
    16501 gcgacgtcgg ggctgatacc cggcatctcg ggcatgagga tgactgccgg tcccgacccc
    16561 gtgacgtaca cggtcttgtc gacgtcatcg acgctgacgg ctctgcgtga gaagtcgtcc
    16621 agggggtcgc tctgtcctcg catgatggtc atgaccgaga tgatgacgag cggccgccct
    16681 tccccagaag cggcgtcatc gccacgtatc acggtaatat cgccacccgt tcgaggctgc
    16741 cggaaagccg gaggagctgg cggagctgga ggggccgcat gagtccgctg cgcgtcggcg
    16801 tgctggcgta ccccggctgc ttcgcgtcgg aggtgttcgg cgtcccagac ctcctggcca
    16861 tggcctctca cgtcgccgcg gcacaaggag cggtccagcc ggcctacgag acgtcggtca
    16921 tctcgccccg gcgtcgggtg atcgcagccg gcggctccgt cctcgacgtg gcggcggttc
    16981 gcccggtgga cgtcctgatc gtgccggggt tcgagctttc gcccacgctc gatctgaacg
    17041 cgacactcgc ccacctgaaa ccggaagcgg cgtcgatccg gtcgcaggcg gcctcggggg
    17101 ccgctgtcgt atcgatctgc gtgggtgcct tcctggtcgc cgaagcaggg ctgctcgacg
    17161 gacgccaggc gaccacgtcc tggctgttcg cggatcggtt cgcccgccgg tacgccgacg
    17221 tgcgcctgcg cccggagagc ttggtcgtca ccgaccgggg ggtgacgacc acagcggcct
    17281 tcagtgccat gtacgacttc gccctgcagc tcatccgcga gcacgacggt ccccgtgtcg
    17341 cacggagcac cgcgcgcatc gcgctggtag atgacgcgcg ttccacgcag gctccctatg
    17401 tcgacccgga tctcataccc actgtgggca gggagttctc gctcagcgtc aagcggtggc
    17461 tcgaccagaa cctcactgct cgctacgacc tgcccgccct cgcccaggag ttccacgtca
    17521 gcaccagaac cttgctccgc cgcttccgcg acgaggccgg cgagacgcca ctcgcgtacc
    17581 tgcagacagt tcgggtacgt cgggcccgac acctgctgga gacgaccgac aggaccgtcg
    17641 cgagcatcgc cgccgacgtc gggtacggcg accctgggac attcagcagc gtcttcgcca
    17701 gacatacagg ccagcggcca agggagtacc gcgcgatatt ccgtcgccgc cgcgaccctc
    17761 acggatccat tcggcgaacg gagacttgag cgtcccggtc ccgctgctcc tgcgtcagct
    17821 cgtggtgccg tcggagttcc tcaggacgtc gagagccctg tcgaaggccg agtccctctg
    17881 cttgtcgaac tcttccttcg tgaagaccgg ctccgtgagg tgcggcggaa tgcccgtgcc
    17941 gtcgaaggtc ctgcccgacc gggtcaggaa ctcctcgttg ggcagccagg ccgacatgcc
    18001 gttggggagg gtgcgcgaca tgacgtccga gaagactccc tgggtgggcc ggccgatccg
    18061 gacggtcttg ccgggccggt acatgagggc ctgggtgaag gtctcccccg cgctgaaggt
    18121 cgagccgccg gtcagcacgg cgaccggccc ggtgtaacgg ggtccttggg cgggcgtgac
    18181 gtagacgggc tgggggcggg tgtgccggga ggggtcggcg gggtcgttgc gggccctttt
    18241 ggagtaggcg aggtaggcgg tgtcggtgag gcgctcggcg atgtggacac ccagggcgtc
    18301 ggaaccgccg ccattgatcc gcacgtcgat gatcaggccc ttcaggcgct gggtgcgctc
    18361 ccggctgagg accgtgtcca gcgccctgtc cagctcggcc aactgggcgg cgtaggaggc
    18421 gccatgaccc gcgtatccgc cgaacccgga gatccgcaca tagccctgtg cgccggggag
    18481 gtcagcgtag gtgatccgcc cgttggcgaa gtcctgcagg ttccgggcgt tcttgaggtc
    18541 gcgcgccacg acgaactgct tgaccttggt gtccaactcc tcggtgggca cggcggtgcc
    18601 gggtcgaacc tgtgcgaaga cgcggtcgcc gtcctggacg gcgacgtggg catcgtggag
    18661 cggcttgacc atctcgctga agacggcgta cagctcgtcc ctcgtcgtcc cggcgtgtac
    18721 ccgggggcgg taccggtcgc gtactgcgtg ccagtcgatg cccttggcgg cgaagaaggg
    18781 gtagttctcc tcgaaggact gccagaagac gtcaaaggcg gcgagcgggc cttcgggggc
    18841 cggacgcgtg caggcgtcgg gcaactcagg gatccgatgc aggttccggt cgccgaccga
    18901 gccgtccacc cgcaaggacc cgcggtcgcc gcctccttgg acgcgcaccg tgaggacggt
    18961 gccgtcaggc atggtgtagg tgccggggcc gctccgctcg gcggaatcgc ccttgagaca
    19021 gctgacggtg gtggtctggt actcctggaa ggttccgttc cggatggaca ggacggtgcc
    19081 gtagccgtcc atgcgccaga ttccgtcggc ggtcgggtgg tgggcggtgg cggccggaac
    19141 ggcttggccg gcgagggcca aggcagcggc ggtggccgtg acaatgcgca cgatcttgcc
    19201 ttctctgggg gcgacttgct cgggacaggt ccacagtcgc cgccaaggcg ttctcccggc
    19261 catccggctg tccggttgat cgaaggtggg gccagccccc gctgtcggca gcgtcaggga
    19321 gcgatcgccg tatcggctcg cagggcgatg cggggcgcgg accccggcag cgcggccgtc
    19381 gcaggccctg ctcgcggctg cgcccgaaga gcgacggcgt ccctcgttgc tccgcacccg
    19441 tcggcgccgg actcggggcc gtccggaccg gcgggcgggg cgacgtcact caggggcgcc
    19501 gagcggcggg tgctcgagca cgcggggctt gtactcgacc agctggatgc ggccgtcgaa
    19561 ggtgcggtgg tcgatcatct caagggcgac gtccggatag ccgtcgtaga tgcgttcctc
    19621 gcccgtggcc ccggtgatca ccgggaacat cacgacccgg aagcggtcga cgagtccggc
    19681 ccgtagcagg gaccggcaca ggctgagact gccgatcgtg ctgaggagtc ccgagccgct
    19741 ggacttcatg gcgcggaccg tctccacggc gtcgtcgcgc acgagcgtgg agttggccca
    19801 cgtcagtggc tcctcgagcg aggaggagaa caccaccttg ggggcctgtg tgagttggtc
    19861 gacggactcc tcttcctccg gcctgaactc gtcttggccc tccgggacct cgcctgcggc
    19921 gaaccctgac atcaggcgat aggtgttcgc tcccatcagg taggtggctt cgggctgctc
    19981 accgagccat gcgaggtact ccgggccctc caggccccag aacccgggcc atccccgtcc
    20041 cgatgcgtag ccgtcgaggg aggtgatgaa gtcgacgaga agctccgaca tggcggtgtc
    20101 cttcctggag tgtcatgagc ttggaccggc cgggatccac gaactcatcg gccgcgccga
    20161 cctgggcttg gtcgcgcccc tcgccgtggc cctctggcgg cgcgcgttac gcagcaggcg
    20221 tcgtctcact cctcccccgg cccggcaccg atccgcgcca ggtccgccgt cagtgattcc
    20281 agccacgaca ccgtcgcgta gtacagccgc ggtgcgtccg tcggctcggt cgtggattcc
    20341 gcgagggtca tctcgatcga cggcacgggc gcggtgggcg tgtcgccgcc cgggtccagg
    20401 gctgccgaga ccagcagcat ccggcccgcc acgcgttcgc cgacgccggt gagcgcctcc
    20461 gccgcggccg ggcccagtac ggcgtgcggt ggctccagca gcctctgcga gccccacagg
    20521 gtgtggtggc ccgccatcag cgtcgcctgc cagtccaccg cgggtgaggt cgctcggcca
    20581 ccgaggcgtg cgggttcgct ctggtactgg gcgtacgcgg actcagcgag gatgaccgag
    20641 cggtgcagcg accggtggcc gggcggtgcc cccgagggca gggccgacgc cgtgccccgc
    20701 gcggccgagg cgctggtcgc cacgacgatc tccgccgccc tgcgcagcag ctccgcggcc
    20761 gcgtagcgca gctcgtcatg ggcgccgcgc ggccaggcca gcagtccgaa gaccgcgccg
    20821 atcgcgctgc cgaccagcac gtcgagcatc cgcacctccg ccaggtgcca ggtgggcggc
    20881 gcgagctgcg cgaagaccag tgccacgagc acggtgaaca tgccctgtgc ccagccgaca
    20941 ccccgcaccg gcccgaccgt gaagacgatc agcatccaca gcggcagcag caccgcgtag
    21001 aaacgggtgt ccgtcccggc cagggtcagc gtcccggcgg tcaccagcgc gccgacgagg
    21061 gtgccggtga gcgccaggcg gacggtgtgg cgggtctcgt ccagcgtcgt acgggtgagg
    21121 gtgagggtcg ccagcatggc ccagaacccg tgcggcagcg tgtccacccc ggccaccagc
    21181 cgtgcggccg tcagcgccag ggcgatgcgc accgcgttct ggaagaacac cgagcggcgc
    21241 ccggcgtgcc cgcgcagccg gtgccaccac agcagcggcg cccccatcga ggcgtaccag
    21301 aagcggcccg gcgggatcgg cacccgggcg tgccggccgt gtacggcgag gtcggcggcc
    21361 acgcccatgg cgagtgccgc gtcggccacc tccagcacgg cggcgtgccc gcgcagcacc
    21421 gcggccggga aggccggcgc acaagcggtg ccgggaaacg gcccggcgga gacggccgac
    21481 aggcgtgcgc gcgccccgac cagcgcctgg tacggcccca gcggtgacgg cccggaaccc
    21541 agacagccgg cggtcgcctc ccccagctcg gccaccgcgc ggagcacggc tgtgacctcg
    21601 gtgtccgccg cgttgcggtc tgtgcgcaga cccgccagcc ggctgagcag ggtgcgggtc
    21661 gcgaggccgg tgtgcgccag ggcgcgctca cgtctgcccg gcccggccgg gcgtaccgcc
    21721 tccggcacat gcagtggccg gagcccttgc acggcatcct gggccgccgc ccggtcctcg
    21781 ccggtcaggg tgtacggcgg tgcggcgagg cctcgcgcgc accgcgcggc
//
