LOCUS       NZ_BNBR01000001        22160 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000001
VERSION     NZ_BNBR01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 2104813)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1739773
            Orig. end                         :: 1761933
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22160
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="terpene"
                     /product="butyrolactone"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..22160
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22160
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12160](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12160)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(216..1538)
                     /locus_tag="IE308_RS07660"
                     /old_locus_tag="GCM10018783_15640"
     CDS             complement(216..1538)
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125306.1"
                     /locus_tag="IE308_RS07660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15640"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_190217114.1"
                     /transl_table=11
                     /translation="MDELADKAAALVARRPRHARLRRVGTSRAGAPLWLLSVGHGSRQA
                     LVVAGPHANEPVGGATALRLAERVLADPSLTEGADATWNLLLCLDPDGLRRNEDWLSGP
                     YTLGHYFRHFFRPGFLEQPEWLPDGAAAAVLPETRTLLALQDELKPFFQASLHGVDVGG
                     GFVELTHDLPGLADRMAGIARRLGVPRELGPYDTLYWPVLGPAVHLIPPPQRGDLAAAI
                     TEAAVESTWYHPHRYGTVTAIVEAPMWGVAAVEDGSPPADRDAVLRTISRTLRHDARTL
                     ELLLARIRPLLAAVPDAARLLAPVGDYLLVCPGLADAWDPDRGVQDRPLPPLMTAHLAA
                     LRIAGRRLALRTAGLLHQLVTGAGAVAAGALPELDRLIDAWCADYRDGCGARWIPVARQ
                     VEYQARVVLAAFELAAHRAPEGARSGEPGWCSGTAVPMHQE"
     misc_feature    complement(612..614)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1684..2235)
                     /locus_tag="IE308_RS07665"
                     /old_locus_tag="GCM10018783_15650"
     CDS             complement(1684..2235)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385491.1"
                     /locus_tag="IE308_RS07665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15650"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_110632097.1"
                     /transl_table=11
                     /translation="MTSSFEFHTYPARLSDAERDRALKVLRDGVALGRLSHDTFIRRME
                     LALAARRSDELAALTADLPQDNRVSRALFGAVEAVSGFTVRLRRAWQAERLPKLLLPHP
                     GTGHPLRIGRDPGNGLRLTHETVSRMHAELSRQGGLWVLRDLGSTNGTTVNGRRVIGAA
                     VVREGDQVGFGSVAYRLSAH"
     gene            2410..4155
                     /gene="treZ"
                     /locus_tag="IE308_RS07670"
                     /old_locus_tag="GCM10018783_15660"
     CDS             2410..4155
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034231.1"
                     /locus_tag="IE308_RS07670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15660"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_190217115.1"
                     /sec_met_domain="Alpha-amylase (E-value: 5.2e-12, bitscore:
                     42.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRVSLECDGVTRALERDPQRAGWWTGEAEARDGSR
                     YGFAVDDGPLRPDPRSRRQPDGPDGLSAVVDHGRYEWRTEWAGRPLPGAVLYELHVGTY
                     TPEGTLDAAADRLGHLVELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHELGLGVVLDVVHNHLGPSGNYLPVFGPYFTDRHQTPWGSAVNLDAPGSDEVR
                     AYLVGSALAWLRDYRIDGLRLDAVHALVDTRACHFLEELSAAVDTLAAETGRPLFLIAE
                     SDLNDPRLITPREEHGLGLHAQWNDDFHHALHTALTGESQGYYADFARAPFAALAKTLT
                     GGYFHDGSYSSFRGRSHGRPLDRGRVGGHRLLGYSQTHDQVGNRAQGDRLSASLSPGLL
                     ACAAALTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPVLADAVRRGRRREFAAHGWAED
                     EVPDPQDPATRERSCLDWSEPEREPHARVLAWYRRLIALRHTQPDLTDPDLADLKVAYD
                     EEARWLAFRRGDVRVAVNLSKEPAAIPLGTRPARVLAAWDEVSGPGEDGMLRLPGESCV
                     VLEQD"
     gene            complement(4224..5174)
                     /locus_tag="IE308_RS07675"
                     /old_locus_tag="GCM10018783_15670"
     CDS             complement(4224..5174)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125303.1"
                     /locus_tag="IE308_RS07675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15670"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_190217116.1"
                     /sec_met_domain="APH (E-value: 5.1e-20, bitscore: 69.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRTLLKEGKGADGTAGPDVRPVAGDGEHST
                     WWVGTRHVLRLAPDREAAVRQRRELRLRDLVRPHVPVAVPTSVAHGEWTPGLTYTLDTK
                     VPGATAEDHDVSAVGEADLAGLLTGLREVPARQAEALGVPRAAPRSLEALRRMAVSAAR
                     GLGDADEFDPARLSQLTPPGAAQLAAQPGAAVLVHHALRGEHLVVSADGRVRGVLDWTQ
                     AVLGDPAEDIAGLALAVGSGAAVRAATLAGYGARPCLRGLWLARCDTVLHLAARLDGRD
                     TAPLPLLRTQLRRAWEAILLERVTELREGGPEDEA"
     gene            complement(5222..6349)
                     /locus_tag="IE308_RS07680"
                     /old_locus_tag="GCM10018783_15680"
     CDS             complement(5222..6349)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="IE308_RS07680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15680"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_190217117.1"
                     /transl_table=11
                     /translation="MTGTAAAPFTADDYRARMERAVTAAADAGLAGLLVAPGPDLVWLT
                     GYAPTAVTERLTLLVLTPDRDPVLVVPALEAPDAAKAAGASALTLRDWTDGKDPYAATA
                     ALLDARGRYGISDTTWALHLLALQRALPDSGYASLTDALPMLRAVKDAAELGLLAAAGA
                     AADRAFEEIRTMRFAGRRETEVGADLADLLRRFGHSQVDFTIVGSGPNGANPHHEVGDR
                     VIEPGDMVVLDFGGLKDGYGSDTTRTVHVGEPTEEERRVHDIVRAAQEAGVAAVRPGAA
                     CQDVDRAARAVITDAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGI
                     YLPGRFGVRIEDIVTVTGDGGRRLNNTTREMVIVD"
     misc_feature    6578..6589
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.45"
                     /tool="antismash"
     gene            6616..7380
                     /locus_tag="IE308_RS07685"
                     /old_locus_tag="GCM10018783_15690"
     CDS             6616..7380
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385485.1"
                     /locus_tag="IE308_RS07685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15690"
                     /product="metallophosphoesterase"
                     /protein_id="WP_190217118.1"
                     /sec_met_domain="Metallophos_2 (E-value: 1.9e-07, bitscore:
                     28.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVLAHISDLHLDGSARATERAERVRDHLWGLPGPVDALLVTGDI
                     ADHAAEPEYEEAARLLGLREDGGSAPAPFPVLTCPGNHDSRAPYRKALLGQEPSGAPVN
                     SVRVFEGGAVLMCDSSVPGEDDGALEEETYAWIEATLDDLGGRLPVLLAFHHPPVALHH
                     PLPDSYRLGRPEALAALMERRPEIAGLITGHAHTPAATSFAGRPLVVGPGVTWTLRLPW
                     EGEQIADRDAPVGLAFHILTDDGRLTSHFRVV"
     gene            complement(7426..8007)
                     /locus_tag="IE308_RS07690"
                     /old_locus_tag="GCM10018783_15700"
     CDS             complement(7426..8007)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675702.1"
                     /locus_tag="IE308_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15700"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_190217119.1"
                     /transl_table=11
                     /translation="MEPTALRPKPMPGQEPGGPRSGGPAPRRPHAARRRGRRLSTLLLG
                     LVLLLAGVGLGTVGATVIGMSKLADLQRQASHTPQAPHAAHAPDRPAPAPPSASPSPTP
                     PVRAGLGVEAMDAEKAGALVVGVHVPGPGYAAGLVRGDILLAFDHTRIDSAADLARAVA
                     HARPGSEVTLTVRHRSGGYQQLTAVLGVVV"
     gene            complement(8136..9002)
                     /locus_tag="IE308_RS07695"
                     /old_locus_tag="GCM10018783_15710"
     CDS             complement(8136..9002)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890208.1"
                     /locus_tag="IE308_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15710"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_190217120.1"
                     /transl_table=11
                     /translation="MDPHLLRTYVTVARLASFSEAARELGYTQSAVSQHIAALEQDLGA
                     PLLTRRPVAPTAAGERLLEHAGPLLLRLDAARADVARMAAAPQQGLTLAAAPTALAPGV
                     LAALPPAGTTLRVLARDEIPAAVATGAVELGLVDGLAAPSDPLRLPDVAPLTTRGVTEE
                     PVSVLLPAGHPLARRPALRLGDLADARWLDAPGAGLPLAQLRATDGGRGFRPSLRYDGT
                     DLRTLTALAAAGHGLALLPASAAAGVPGAVAVPVTEPRVVHRVELVYASVPRGAAAALA
                     DTLTGAS"
     gene            9098..9832
                     /locus_tag="IE308_RS07700"
                     /old_locus_tag="GCM10018783_15720"
     CDS             9098..9832
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547157.1"
                     /locus_tag="IE308_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15720"
                     /product="hypothetical protein"
                     /protein_id="WP_190217121.1"
                     /transl_table=11
                     /translation="MTHTASPAARIALVGDRSPNVVSHTRIPLLLDALAERDRLVLDAY
                     WIPSEDAAAEGAVRGFDAVWVLPGSPYRSEEGVLAAVRAAREDGVPFLGTCGGFQHALL
                     EYARHVCGLTRVAHAENDPDAEDFLIEPLACSLVGHEAAVVIEPGSLAQSVIGAERTVE
                     RYFCAYGPSRHLDTLRAHGMRFSGHDEEGHVRVAELPGHPFFLATLFQPELYGDGSRPH
                     PVVRALARAAVAHARGEAPQPV"
     gene            9829..10014
                     /locus_tag="IE308_RS07705"
                     /old_locus_tag="GCM10018783_15730"
     CDS             9829..10014
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE308_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018783_15730"
                     /product="hypothetical protein"
                     /protein_id="WP_190217122.1"
                     /transl_table=11
                     /translation="MTYDEHYRLTLALTDADLPEEARALRTAAASLLGELSEDAAAGVR
                     ELAREAAAHIGQVSRG"
     gene            complement(10001..12160)
                     /gene="cyc2"
                     /locus_tag="IE308_RS07710"
                     /old_locus_tag="GCM10018783_15740"
     CDS             complement(10001..12160)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675700.1"
                     /locus_tag="IE308_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15740"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_190217123.1"
                     /sec_met_domain="T1TS (E-value: 3.1e-80, bitscore: 267.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPYPARLNPHVDEARAHSTQWARDMGMLEGSGIW
                     EQADLDAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLDMFKRTQDRAAGKAH
                     LDRLPLFMPLDLATPVPEPRNPVEAGLADLWARTVPAMSVDWRRRFAVATEHLLNESMW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPASVAGARPLRVLMETFSD
                     AVHLRNDLFSYQREVEDEGENSNGVLVLETFFGCTTQQAADTVNDILTSRLHQFEHTAL
                     TEVPALAVEKGLGPAEVAAVAAYTKGLQDWQSGGHEWHLRSSRYMNEGARSSSPWQVIG
                     GRGTSAADVGALLAGAAQDRLRAYRHVPFQKVGPSRIPDFYMPFELQLSPHLDGTRARL
                     ADWCRAMGILQEGVWDEDKLRAYDLALCSAGLDPDATREALDLSACWLAFGTYGDDYYP
                     LVYGHRRDLAAARLTTARLSACMPLDGEEPIAPANAMERALIDLWERTTASMTLEQRRS
                     VKASVDVMTESWVWELSNQIQNRIPDPVDYLEMRRQTFGSDLTLSLCRMGHGPDVPPEV
                     YASGPVTSLETAAMDYACLLNDIFSYQKEIEYEGEIHNAILVVQNFFGCDYPQALGVVH
                     DLTTQRMQQFEHVVAHELPVLYDDLGLSAEARAAMHGYVADLRNWLAGILNWHRSVDRY
                     RAEWLARRAHGFLPDRPPAPVLSLG"
     cand_cluster    10556..21458
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    10556..21458
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[15555:16458](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(15556..16458)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     gene            12312..13556
                     /locus_tag="IE308_RS07715"
                     /old_locus_tag="GCM10018783_15750"
     CDS             12312..13556
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575915.1"
                     /locus_tag="IE308_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15750"
                     /product="cytochrome P450"
                     /protein_id="WP_190217124.1"
                     /sec_met_domain="p450 (E-value: 2.2e-21, bitscore: 72.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPDVFDPRRYAAGVPYADYRALRDHHPVAWQEEPEVLGWPAGP
                     GFWAVTRHADVVRVLKDAATYSSHLGATQIRDPDPDDLPFIRRMMLNQDPPAHGRLRRL
                     VSRAFTPGRVERFTAVAEERARTLLGDALARARAGDGTVDVVAAVTDDYALLNLADLLG
                     VPESDRGLLLHWTRRVIGYQDPDEAGPEVRDTAGRPVDPRSPAMLRDMFAYAHRLAAHK
                     RRHPGDDVLTTLAQERELADGELEMFFFLLTVAGNDTVRSAAPGGLLELAGHPEAYRRL
                     RTGQAELGAAVEELLRRHPPVLTFRRTAARDTELAGRRIRAGDKVVVFHASANRDERVF
                     ADPDGLDLGRSPNPHVSFGDGPHVCLGAHFARLQLRVLYRQVLLALPELRTAAPPRRLV
                     SNFINGIKSLELQVT"
     gene            complement(13564..14790)
                     /locus_tag="IE308_RS07720"
                     /old_locus_tag="GCM10018783_15760"
     CDS             complement(13564..14790)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675697.1"
                     /locus_tag="IE308_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15760"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_190217125.1"
                     /transl_table=11
                     /translation="MPDSPAPTPGAPVLVGGAPGTFPHSVLAERHPAIIRQVRDAFPYG
                     PGIRRALDALLESCTDGVIEPLPAEAPDRDRWHTWGLGEHTGRSWFEVPWLWAESYFYR
                     RLLEATGYFTPGPWQGIDPFRPSKLAELDSAETEEELAALDDLTSRPSDERAQALLHGS
                     LWGNRADLGFRLSAGAAGAAGPGTGADAPRTPVAPALVADDSAALWALLPPGGAGTLCL
                     VADNAGRELIPDLLLLAHLLDAGRVARAVLHLKPQPYYVSDATTADLLDALRRLAAAPG
                     AARAYGRRLWEALSDGTLTVRAHPFSAGPLPYAAMPGDLRAEFAGYTLTVLKGDLNYRR
                     LVGDRLWPPTTSFADVTAHFPGPVAALRTLKSDVITGLDAATEAALVAAEGQRWRTGGT
                     HALIQVREK"
     gene            complement(14829..15485)
                     /locus_tag="IE308_RS07725"
                     /old_locus_tag="GCM10018783_15770"
     CDS             complement(14829..15485)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381314.1"
                     /locus_tag="IE308_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15770"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_190217126.1"
                     /transl_table=11
                     /translation="MPRQLRAEQTRATIITAAADLFDQRGYEATSLSDIVQHAKVTKGA
                     LYFHFAAKEDLAHAIMELQSEVSRQVTGEVDGHDYPSLEALIRIVFAMTRLSVEGPVTR
                     AGLRLATGPVPLREPLRHPFSEWLEIVTHRLQSAVRESDLHPDVDVDAVAHSLVSFFVG
                     TRVVGRSLEPVARLPRRTAEMWRVLVRGLVPVPRRPRYMTLITRLEREVMAAAAV"
     misc_feature    complement(15471..15473)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15556..16458)
                     /locus_tag="IE308_RS07730"
                     /old_locus_tag="GCM10018783_15780"
     CDS             complement(15556..16458)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657052.1"
                     /locus_tag="IE308_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15780"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_190217127.1"
                     /sec_met_domain="AfsA (E-value: 6.7e-22, bitscore: 74.2,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQPRQLAGNPAMTATVPRQLVHRAAVAETLLTGWHRLADDRFTV
                     AAQWPRAHGLHVSADWTAYDPLLAVETVRQSGTLLTHAEYDVPLGHRFVLDAFDVTTFP
                     EHLGVGALPAEIEVDVVFTDVQYRGRRPVSARYTAEVLRCGERAATADVAFTCMSEAVY
                     RRLRSGRTPETVTALPAPAGLPPEAVDRALPGDVVLAPADRRGRWRLRVDTAHPVFFDH
                     PLDHVPGTLLLEAARQATVVHTAGQRVPVAYRSRFHRYAELDEPAWIEVRRTDAAGIQV
                     VGVQGGSTLFECLVATADR"
     misc_feature    complement(16294..16296)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16551..16564
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.47"
                     /tool="antismash"
     gene            16646..17332
                     /locus_tag="IE308_RS07735"
                     /old_locus_tag="GCM10018783_15790"
     CDS             16646..17332
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007502447.1"
                     /locus_tag="IE308_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15790"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_190217128.1"
                     /transl_table=11
                     /translation="MARQERAIRTRRMILEAAGAVFDEHGYASTTIAMVLERAEVTKGA
                     LYFHFPSKESLAQAVLAEQVLFGAVPSRSSKLQEVIDMTFAVGQRLRSNALLRGGVRLA
                     VDQETPSGIDRGEPFRQWSRRLTALLERAAEQGELLPTVRPADTVDLLVGAFTGIQLMS
                     RALTDRADLADRLAVLWAHMLPSIAVPGLLPGLDSRADRGVRVLAEIDPAQAGAEAEER
                     TPAGVR"
     assembly_gap    17358..17391
                     /estimated_length=34
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(17478..19283)
                     /locus_tag="IE308_RS07740"
                     /old_locus_tag="GCM10018783_15800"
     CDS             complement(17478..19283)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125294.1"
                     /locus_tag="IE308_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15800"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_190217129.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.1e-52, bitscore:
                     176.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTPHATGRKLISVAAVSAALLTAATAAVAAAPQAPTAEAAVPAA
                     QTEAAPGVPAERLIVGYKPGAEEATSNRAAEADAAAKGKEAGTDADFRRRLGTGAALVD
                     LGARATRADVADVVAEFRADPQVAYVVPDRLNKPMATPNDTEYGKQWDLFEETAGMRVP
                     GAWDIATGSGVTVAVIDTGYVAHSDLAANIVGGYDFISDTAVSVDGDGRDSNPADPGDW
                     YADNECGTNVPGSNSSWHGTHVAGTIAAVTNNGKGVAGIAYGAKISPLRVLGKCGGYDS
                     DIIDAITWASGGTVSGVPANSNVAKVINMSLGGDGACTSATQNAINAAVSRGTTVVVAA
                     GNENDNVANHSPGNCNNVISVAATNRTGSKASYSNYGSLVDISAPGGQTSTGTANGILS
                     TLNSGTRTPSTESYAYYQGTSMATPHIAGLVALMKSANASLTPAQIESAIKANARPLPG
                     TCSGGCGAGLADAAKTVQAVSGSGGSTGGTTFTNSTAVAIPDAGSAITSSLAVSGLSGN
                     APATLKVAVNITHTYRGDLVIDLVAPDGTAYRLKNSSSSDSADNVNTTYTVDASSEAAN
                     GTWKLRVQDVASYDTGTLNSWALTF"
     misc_feature    19435..19451
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            19648..20595
                     /locus_tag="IE308_RS07745"
                     /old_locus_tag="GCM10018783_15810"
     CDS             19648..20595
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431988.1"
                     /locus_tag="IE308_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15810"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_190217130.1"
                     /transl_table=11
                     /translation="MPRKTTPRRRTALAATAAAPLLLGLWAAGPAGAHGAPTDPVSRVY
                     ACSPEGGAAARSAACRAAVAANGGTPFTAWDNLRVADVGGRDRRVIPDGELCSGGLAAY
                     RGLDLARTDWPSTRLTPGTTVTLRYASTIPHTGTFRLYLTEAGYDPSRPLTWSDLPERP
                     LAEVKDPPLTDGAYRIPVRLPADRTGRHVLYTVWQNSSTPDTYYSCSDVVLAGGAPTRP
                     KPSQAAPAAGPKPSGATPAGTTPASTTPAGTTPASTPPAGTAPAPTAVVGAARTAADTG
                     GASFAPGAPLLAGGAAAVLLLTGGAALAVRLRRR"
     gene            complement(20614..21267)
                     /locus_tag="IE308_RS07750"
                     /old_locus_tag="GCM10018783_15820"
     CDS             complement(20614..21267)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675693.1"
                     /locus_tag="IE308_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_15820"
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_110632053.1"
                     /transl_table=11
                     /translation="MRTRSLLTVAGAVVALALPATLPASAADTAVLTTGGAGGTPVATG
                     SVLTASLASGTAATFYSSADGTSGLRCTSSQFTATVTGNPSAPGTATESVTAHTFDAAS
                     CTSNVTGVLGVSGITVDHLPYTATVTSAGALDVTPPAGSTVQTTVKLRTLLGTVTCVYQ
                     GPGLSGTASNADNSITFDDQHFTKISGSSLCFSNAYFTAKYAPVTTGGAAVYVN"
     misc_feature    21474..21489
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.12"
                     /tool="antismash"
     misc_feature    21751..21762
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.19"
                     /tool="antismash"
ORIGIN
        1 cgcgtcaccc cgggtcacgg tgaggtacag ccagtcgtcg agcggcacga cgggcgtggg
       61 caggtcagcg gtggccggcc gctcgaccgg cccggggacg gctgcggtgg ccggcagccc
      121 gcccggcacg gccagggccg cggcggccgg ctgcgcggcg acggtgagga gggcggccga
      181 cagcaggccg ccgacgatcg atcgtgcgag gtacgtcatt cctggtgcat cggcacggcg
      241 gtgcccgagc accaccccgg ctcacccgaa cgagccccct ccggcgcgcg gtgcgccgcc
      301 agttcgaacg cggcgagcac cacccgcgcc tggtactcca cctgccgcgc gaccgggatc
      361 cagcgcgccc cgcagccgtc gcggtagtcg gcgcaccagg cgtcgatgag ccggtccagc
      421 tcgggcagcg caccggccgc gaccgccccg gcgcccgtga cgagctggtg gagcagtccc
      481 gcggtgcgca gggcgaggcg ccggccggcg atgcgcaggg cggccaggtg ggcggtcatc
      541 aggggcggca gcggccggtc ctggacgccc cggtcggggt cccaggcgtc ggccaggccg
      601 gggcagacca gtaaatagtc gccgaccggg gcgagcaggc gggcggcgtc gggcaccgcc
      661 gcgagcagcg gacggatccg ggccagcagc agctccaggg tgcgggcgtc gtggcgcagg
      721 gtcctgctga tcgtgcgcag gacggcgtcc cggtcggcgg gcggcgagcc gtcctccacg
      781 gccgccacgc cccacatggg cgcctcgacg atcgcggtga cggtgccgta gcggtgcggg
      841 tggtaccagg tggactcgac cgccgcctcg gtgatggccg cggccaggtc gccgcgctgc
      901 ggtggcggga tcagatggac ggcggggccg aggaccggcc agtacagggt gtcgtacggg
      961 cccagctcgc gcggcacgcc caggcggcgg gcgatcccgg ccatccggtc ggcgagtccg
     1021 ggcaggtcat gggtgagttc gacgaagccg ccgccgacgt cgaccccgtg cagggacgcc
     1081 tggaagaaag gtttcagttc gtcctggagg gcgagcagcg tccgcgtctc cggcaggacg
     1141 gccgccgcgg cgccgtcggg cagccactcg ggctgctcca ggaagccggg ccggaagaag
     1201 tgccggaagt agtggccgag ggtgtacggg ccggacagcc agtcctcgtt gcggcgcagc
     1261 ccgtcggggt cgaggcacag cagcaggttc caggtggcgt cggcgccctc ggtgaggctg
     1321 gggtcggcga ggacgcgttc ggcgagccgc agggcggtgg cgccgccgac gggttcgttg
     1381 gcgtgcggtc cggcgacgac gagggcctgc cggctgccgt ggccgacgga cagcagccac
     1441 aggggcgcgc ccgcgcggga ggtgccgacg cgccgcagcc gggcgtggcg ggggcggcgg
     1501 gcgacgagtg cggcggcctt gtcggccagc tcgtccacgc tcgggtagcg gaggagtggc
     1561 ggcagggcac acctccacgt gcggggccgt cggttcacct ggtgtccatg gtgtacgcac
     1621 agtcagtcac ggctcgtcgg ccacgtcaac accgcgacga ccacggaaac ttggtgaccc
     1681 ggttcagtgc gcggagagcc ggtacgccac gctgccgaag cccacctggt cgccttcgcg
     1741 gacgacggcg gcgccgatga cgcggcggcc gttgacggtg gtgccgttgg tggagccgag
     1801 gtcgcgcagc acccacaggc cgccctggcg gctgagttcg gcgtgcatgc gggagaccgt
     1861 ctcgtgggtg agccgcagcc cgttgcccgg gtcgcggccg atgcgcagcg ggtggccggt
     1921 gccggggtgc ggcagcagca gcttgggcag ccgctcggcc tgccaggccc tgcgcagccg
     1981 tacggtgaag ccggagacgg cctcgacggc gccgaacagc gcgcgggaga cgcggttgtc
     2041 ctggggcagg tcggcggtga gggcggccag ctcgtccgag cggcgggcgg cgagcgccag
     2101 ctccatccgg cggatgaacg tgtcgtggga caggcggccc agggcgacgc cgtcacggag
     2161 caccttcagc gcccggtcgc gctccgcgtc ggagagccgc gcggggtagg tatggaactc
     2221 gaaggacgac gtcacgcgtg tgattgtcgg tcagcggagt gcgggtgtcc agaaagcgga
     2281 gaaacggggc cacgcgcgcg tacctgtgcc gacacccgcc gcaaaaggaa tgattcaaaa
     2341 gcggattgat ctcgtttgac gcaggatgga cgggctacat cacggtgagc agacgaaggg
     2401 gaaccgtccg tgcagttcga ggtgtgggca ccacaggccg atcgggtgtc gctggagtgc
     2461 gacggcgtca cgcgcgcgtt ggagcgcgat ccgcagcggg cggggtggtg gacgggggag
     2521 gccgaggcgc gggacggctc gcggtacggc ttcgcggtgg acgacggccc gctgcggccg
     2581 gatccccgct cgcggcgcca gccggacggt ccggacgggc tgagcgccgt cgtggaccac
     2641 gggcggtacg agtggcgcac ggagtgggcg ggccgcccgc tgccgggcgc ggtgctgtac
     2701 gagctgcacg tgggcacgta cacccctgag ggcacgctgg acgcggcggc tgaccggctc
     2761 gggcatctgg tcgaactggg tgtgacgcac gtggagttga tgccgctgtg tccgttcccg
     2821 gggcggcacg gctgggggta cgagggggtg tcgctgtggg cggtgcacga gccgtacggc
     2881 ggccccgagg cgctgaagcg gttcgtggac cgggcgcacg agctggggct cggcgtggtc
     2941 ctggacgtgg tccacaacca cctcggtccg tccggcaact acctgccggt cttcgggccg
     3001 tacttcaccg accggcacca gacgccgtgg ggttcggcgg tgaacctgga cgcgccgggc
     3061 tcggacgagg tgcgcgcgta cctcgtgggc agtgcgctgg cgtggctgcg ggactaccgg
     3121 atcgacgggc tgcggctgga cgcggtgcac gcgctggtcg acacgcgcgc gtgccacttc
     3181 ctggaggagt tgtcggcggc ggtggacacg ctggccgcgg agaccgggcg gccgctgttc
     3241 ctgatcgccg agtccgatct gaacgacccg cggctgatca ccccgcgcga ggagcacggc
     3301 ctcggtctgc acgcccagtg gaacgacgac ttccaccacg ccctgcacac ggcgctgacc
     3361 ggtgagtcgc agggctacta cgccgatttc gcgcgcgccc ccttcgccgc cctggccaag
     3421 accctgacgg gcggttactt ccacgacggg tcgtactcca gtttccgggg ccggagccac
     3481 gggcgcccgc tggaccgggg ccgggtcggc gggcaccggc tgctcggcta cagccagacc
     3541 cacgaccagg tcggcaaccg ggcgcagggc gaccggctgt cggcgtccct gtcgcccggc
     3601 ctgctggcgt gcgcggcggc gctgacgctg acggcgccgt tcacgccgat gctgttcatg
     3661 ggcgaggagt gggcggcggg cacgccctgg cagttcttca ccgaccacac cgacccggtg
     3721 ctggccgacg cggtacggcg gggcaggcgg cgggagttcg cggcgcacgg gtgggcggag
     3781 gacgaggttc cggacccgca ggacccggcg acgcgggagc ggtcctgcct ggactggtcg
     3841 gagccggagc gtgagccgca cgcgcgcgtg ctggcctggt accgccggct gatcgccctg
     3901 cggcacaccc agcccgatct gaccgacccc gacctcgccg acctgaaggt ggcctacgac
     3961 gaggaggccc gctggctggc cttccggcgc ggggacgtgc gggtggccgt gaacctgtcc
     4021 aaggagcccg ccgcgatccc gctgggcacg cgcccggcgc gggtcctggc cgcgtgggac
     4081 gaggtgagcg ggcccgggga ggacgggatg ctgcggctgc ccggggagtc gtgcgtggtg
     4141 ctggagcagg actgacggac tgacgggggc tggggtcggg gccgcgtctg gatccgggtc
     4201 caggtccagg tccaggctca ggcctaggcc tcgtcctccg ggccgccctc cctcagctcc
     4261 gtcacccgtt ccagcaggat cgcctcccag gcgcggcgca gctgggtgcg cagcaggggc
     4321 aggggggcgg tgtcgcggcc gtcgaggcgg gcggcaaggt gcaggaccgt gtcgcagcgg
     4381 gcgagccaca ggccgcgcag gcaggggcgg gcgccgtacc cggcgagggt ggcggcgcgc
     4441 acggcggcgc cggagccgac ggcgagggcg aggcccgcga tgtcctcggc cgggtcgccg
     4501 aggaccgcct gcgtccagtc caggacgccg cggacgcggc cgtcggcgct gacgacgagg
     4561 tgttcgccgc gcagcgcgtg gtggacgagg accgcggcgc cgggctgggc ggcgagctgg
     4621 gccgcgccgg gcggggtgag ctggctcagc cgggccgggt cgaactcgtc ggcgtcgccg
     4681 aggccgcgcg cggcggagac ggccatccgg cgcagcgcct ccagggagcg cggggcggcg
     4741 cgcggcacgc cgagcgcctc ggcctgacgg gcgggcacct cgcgcagtcc ggtgaggagt
     4801 ccggccaggt cggcctcgcc gacggcggag acgtcgtggt cctcggcggt ggcgccgggc
     4861 accttggtgt cgagggtgta ggtgagcccg ggggtccact cgccgtgggc gacgctggtc
     4921 ggcacggcga ccgggacgtg cgggcggacc aggtcgcgca ggcgcagctc gcgccgctgg
     4981 cggacggcgg cctcgcggtc gggggcgagg cgcagcacat ggcgggtgcc gacccaccag
     5041 gtggagtgct cgccgtcgcc ggcgacgggc cgtacgtcgg ggccggcggt gccgtccgcg
     5101 cccttgcctt ccttcagcag ggtacggacc agtcggcgga cggtgtccgc ggtgggtgtc
     5161 ggtgcctggg tcatggtcgc gccgtcgtcg tcggtgtggg tgctggggct gccggggctg
     5221 ctcagtccac tatgaccatc tcgcgggtgg tgttgttcag gcggcgcccg ccgtccccgg
     5281 tgaccgtcac gatgtcctcg atgcgcacgc cgaaccggcc gggcaggtag atgccgggtt
     5341 ccacggagaa gcacatgccg ggcacgaggg gctgttcctc gccctcgatc atgtacggcg
     5401 gctcgtgggt ggtgacgccg atgccgtggc cggtgcggtg gatgaagtac tcgccgtacc
     5461 cggcgtcggt gatgacggcg cgggcggccc ggtcgacgtc ctggcaggcg gcgccggggc
     5521 ggacggcggc gacgccggcc tcctgggcgg cgcgcacgat gtcgtggacg cggcgctcct
     5581 cctcggtggg ttcgccgacg tggacggtgc gggtggtgtc ggagccgtag ccgtccttga
     5641 ggccgccgaa gtcgaggacg accatgtcgc cgggttcgat gacccggtcg ccgacctcgt
     5701 ggtgcgggtt ggcgccgttg gggccggagc cgacgatggt gaagtcgacc tgggagtggc
     5761 cgaagcggcg cagcaggtcg gcgaggtcgg cgccgacctc cgtctcgcgg cggccggcga
     5821 agcgcatggt gcggatctcc tcgaaggccc ggtcggccgc tgcgcccgcg gcggcgagca
     5881 ggccgagttc ggcggcgtcc ttgacggccc gcagcatcgg cagggcgtcg gtgagggagg
     5941 cgtagccgct gtcgggcagg gcgcgttgca gggcgagcag gtgcagggcc caggtggtgt
     6001 cgctgatgcc gtaccggccg cgggcgtcga ggagggcggc ggtggcggcg taggggtcct
     6061 tgccgtcggt ccagtcccgc agggtcagcg cggacgctcc ggcggccttg gcggcgtccg
     6121 gggcctccag ggcggggacg acgaggacgg ggtcgcggtc gggggtgagc accagcaggg
     6181 tgagccgttc ggtgacggcg gtgggcgcgt agccggtgag ccacaccagg tcggggcccg
     6241 gggcgacgag gagtccggcg agtcccgcgt cggcggcggc cgtgacggcg cgctccatgc
     6301 gggcgcggta gtcgtcggcg gtgaacggcg cggctgcggt gccggtcatg cggtcctccc
     6361 tgggcgggtg cggggactga cgggtgtccc tccgcgtcgg tccgttgcct gccagcatcc
     6421 tgcccgcagc gtgggggcgg cgcgagccga tgggcggttt gtcctgggcc atcgtgccgg
     6481 tgcggcggac gccggaccac tggtttcgca cacggcgatc acgggcccgg gtcgagccgc
     6541 ccttgcccgg cccgtgttgc taatgcttgg atgcgccgta aacgttaacc acgatcaggg
     6601 ggagggcgcg acaccgtgct cgtactcgca cacatcagcg atctgcatct ggacggaagc
     6661 gcgcgggcca cggagcgtgc cgagcgggtg cgcgaccatc tgtgggggct gccggggccg
     6721 gtcgacgccc tgctggtgac gggcgacatc gccgaccacg ccgccgagcc ggagtacgag
     6781 gaggccgccc ggctgctcgg cctgcgcgag gacggcgggt ccgcgccggc ccccttcccc
     6841 gtcctgacct gcccgggcaa ccacgacagc cgcgccccct accgcaaggc cctgctcggg
     6901 caggagccgt ccggtgcgcc ggtgaacagc gtgcgggtct tcgagggcgg tgccgtcctg
     6961 atgtgcgact ccagcgttcc gggcgaggac gacggggcgc tggaggagga gacgtacgcc
     7021 tggatcgagg cgacgctcga cgacctgggc ggccggctgc cggtcctcct cgccttccac
     7081 cacccgcccg tcgccctgca ccacccgctg ccggactcct accggctggg ccggcccgag
     7141 gcgctcgcgg cgctgatgga acggcgcccg gagatcgccg ggctgatcac cgggcacgcg
     7201 cacacgcccg ccgcgacctc gttcgccggg cgcccgctcg tcgtggggcc gggggtgacc
     7261 tggacgctgc gcctgccctg ggagggcgag cagatcgccg accgggacgc gccggtcggg
     7321 ctggccttcc acatcctgac cgacgacggg cggctgacca gccacttccg ggtggtctga
     7381 gacaccgggc cgacgccccc gcgtgtccct gggccccgcc tgttcctaga cgacgacgcc
     7441 cagtacggcc gtcaactgct ggtagccccc gctgcggtgc cgcaccgtca gcgtcacctc
     7501 gctgccgggg cgggcgtggg ccaccgcgcg ggcgaggtcc gcggccgagt cgatgcgggt
     7561 gtggtcgaag gcgagcagga tgtcgccgcg gaccaggccg gccgcgtaac cgggaccggg
     7621 gacgtggacg ccgacgacca gggcgcccgc cttctcggcg tccatggcct ccacgccgag
     7681 tccggcccgg acgggcggcg tcggcgaggg gctcgcggac ggcggggcgg gcgcgggccg
     7741 gtccggcgcg tgcgccgcgt gcggggcctg cggggtgtgg gacgcctgcc gctggaggtc
     7801 ggcgagcttg ctcatgccga tgaccgtggc ccccaccgtg ccgaggccga ccccggcgag
     7861 cagcaggacc aggccgagga gcagggtgga cagccgccgg ccgcggcgcc gcgcggcgtg
     7921 cgggcggcgg ggtgccgggc cgccggagcg gggcccgccg ggttcctggc cgggcatcgg
     7981 cttgggacgc aacgcagtcg gttccatgga tcgcctccgg ctggtgctct accctgcgcg
     8041 ccggcgcacg acgtgccacg aacgagtgag actgacccgg cgtcatccac gggaaggggc
     8101 ccgtgtgacg ttcccgggat cccctccgtc cggggtcagg aggccccggt gagcgtgtcc
     8161 gccagcgcgg ccgcggcccc gcgcggcacg ctcgcgtaca cgagttcgac gcggtggacg
     8221 acgcggggct ccgtcaccgg caccgcgacc gcgcccggca ccccggcggc ggccgaggcg
     8281 ggcagcaggg cgaggccgtg gcccgcggcg gccagcgcgg tcagcgtgcg caggtcggtg
     8341 ccgtcatagc gcagggacgg ccggaagccg cggccgccgt ccgtcgcacg cagctgcgcc
     8401 agcggcaggc cggccccggg ggcgtccagc cagcgcgcgt cggcgaggtc gccgagacgc
     8461 agcgccgggc ggcgggccag cggatgcccg gccgggagca ggacgctgac cggttcctcg
     8521 gtcacgccgc gcgtggtcag cggtgccacg tcgggcagcc gcagcgggtc gctgggcgcg
     8581 gcaagcccgt cgaccaggcc cagctccacg gcgcccgtgg cgacggccgc cgggatctcg
     8641 tcgcgggcca ggacgcgcag ggtcgtaccg gccgggggca gggcggcgag cacgccgggg
     8701 gcgagcgcgg tgggggcggc ggcgagggtc aggccctgct ggggcgccgc cgccatgcgc
     8761 gcgacgtcgg cgcgggccgc gtccaggcgc agcagcagcg ggcccgcgtg ctccagcagc
     8821 cgctcgccgg ccgcggtggg ggcgaccggg cggcgggtga gcagcggggc gccgaggtcc
     8881 tgctccagcg cggcgatgtg ctgggagacc gcggactggg tgtagcccag ctcgcgggcg
     8941 gcctccgaga aggaggcgag gcgggccacg gtgacgtacg tgcgcagcag gtgcgggtcc
     9001 atgcccgaca gcatcccacc ccgtataagg aacgctgatc gaccgtgcag gaatcatcgt
     9061 tggacgtgaa gtcgccggcg cgccgaggat ggctcgcatg acgcacaccg catctcccgc
     9121 cgcgcggatc gccctggtcg gcgaccgctc ccccaacgtc gtctcgcaca cgcggatccc
     9181 gctgctgctg gacgccctcg ccgagcgtga ccggctcgtc ctcgacgcct actggattcc
     9241 gagcgaggac gccgccgccg agggcgcggt gcgcggcttc gacgccgtgt gggtgctgcc
     9301 cggcagcccg taccgcagcg aggagggggt cctcgccgcg gtccgcgccg cccgcgagga
     9361 cggggtgccc ttcctcggca cgtgcggcgg tttccagcac gcgctgcttg agtacgcccg
     9421 ccatgtgtgc ggtctgaccc gggtggcgca cgccgagaac gaccccgatg ccgaggactt
     9481 cctgatcgag ccgctggcct gctcgctcgt cggccacgag gcggccgtgg tgatcgagcc
     9541 gggcagcctc gcccagtcgg tgatcggcgc ggagcggacc gtcgagcgct acttctgcgc
     9601 ctacggcccc tcccgccacc tcgacacgct gcgcgcccac ggcatgcgct tctccgggca
     9661 cgacgaggag ggccacgtcc gcgtcgccga actgcccggc caccccttct tcctggcgac
     9721 gctcttccag ccggagctgt acggcgacgg ctcgcgcccc cacccggtgg tgcgggccct
     9781 ggcccgagcc gccgtcgcgc acgcgcgcgg tgaggcgcct cagccggtgt gacctacgac
     9841 gagcactacc ggctcaccct cgctctgacc gatgcggacc tgccggagga ggcccgcgcc
     9901 ctgcgcaccg ccgccgcctc cctgctcggc gagctctccg aggacgccgc cgcgggcgtt
     9961 cgggaactcg ccagggaggc ggcggcacac atagggcagg tcagccgagg ctgaggaccg
    10021 gcgccggggg ccggtccggc aggaagccgt gggcgcggcg ggccagccac tcggcccggt
    10081 aacggtccac gctgcggtgc cagttgagga tgccggccag ccagttccgc aggtccgcga
    10141 catagccgtg catcgccgcg cgcgcctccg cggacagccc caggtcgtcg tagagcaccg
    10201 gcagttcgtg tgcgacgacg tgctcgaact gctgcatgcg ctgggtcgtc aggtcgtgga
    10261 ccacgccgag ggcctgcgga tagtcgcagc cgaagaagtt ctgcacgacg aggatcgcgt
    10321 tgtggatctc gccctcgtac tcgatctcct tctggtagga gaagatgtcg ttgagcaggc
    10381 aggcgtagtc catggcggcc gtctccaggg aggtcaccgg tccgctcgcg tacacctcgg
    10441 gcggcacatc ggggccgtgt cccatgcggc acaggctgag ggtgaggtcg gagccgaagg
    10501 tctggcggcg catctccagg tagtcgaccg ggtcggggat gcggttctgg atctggttgg
    10561 acagctccca cacccagctc tcggtcatca cgtcgaccga ggccttcacc gagcgccgct
    10621 gctccagggt catcgacgcg gtggtgcgct cccacaggtc gatcagggcg cgttccatcg
    10681 cgttggccgg ggcgatcggc tcctcgccgt ccaggggcat gcacgcggac agccgggccg
    10741 tggtcaggcg ggcggcggcc aggtcgcgcc ggtgtccgta gacgagcggg tagtagtcgt
    10801 cgccgtacgt gccgaaggcg agccagcagg cgctgaggtc gagggcctcc cgggtggcgt
    10861 ccgggtcgag gccggcggag cacagggcga ggtcgtaggc gcggagcttg tcctcgtccc
    10921 agacgccctc ctggaggatg cccatggccc ggcaccagtc ggccagacgc gcccgggtac
    10981 cgtccaggtg cgggctgagc tgcagctcga agggcatgta gaagtcgggg atgcgggacg
    11041 ggcccacctt ctggaagggc acgtgccggt aggcgcgcag ccggtcctgg gcggccccgg
    11101 cgagcagcgc gccgacgtcg gcggcggagg tgccgcgccc cccgatgacc tgccacgggg
    11161 aggaggaccg cgcgccctcg ttcatgtagc ggctggagcg cagatgccac tcgtggccgc
    11221 cggactgcca gtcctgcagc cccttggtgt acgcggcgac ggcggcgacc tccgccgggc
    11281 cgagaccctt ctccacggcc agcgcgggca cctcggtgag cgcggtgtgc tcgaactggt
    11341 gcaggcgcga ggtgaggatg tcgttgacgg tgtccgcggc ctgctgggtg gtgcagccga
    11401 agaacgtctc cagcacgagc acgccgttgc tgttctcgcc ctcgtcctcc acctcccgct
    11461 ggtaggagaa caggtcgttg cgcaggtgca cggcgtcgga gaaggtctcc atcagcaccc
    11521 gcagcggcct cgcccccgcg acggacgccg ggacctcggc ggtggcgtac tccaccagcc
    11581 ccgccgacca gggcgcgccg ccgaccttgc ggcgcatctc gatgtactcg accgggttgg
    11641 cgatccgccc ctcgttgatg ttggacagct cccacatcga ctcgttgagc aggtgctcgg
    11701 tggcgacggc gaaccggcga cgccagtcca ccgacatcgc cggcacggtc cgcgcccaca
    11761 gatcggcgag gcccgcctcg accgggttgc gcggctccgg caccggcgtg gccaggtcca
    11821 gcggcatgaa cagcgggagc cggtccaggt gggccttgcc ggcggcgcgg tcctgggtgc
    11881 gcttgaacat gtcgaggaag tggtcgtcga agaagaacac ccacacgtac cagtcggtga
    11941 tcagcgagag ggcggggccg tcgcagtcgg ggtgggtgta ggcgcagagc aggccgtagt
    12001 cgtgcgcgtc gaggtcggcc tgctcccaga tcccggaccc ctccagcatg cccatgtcgc
    12061 gggcccactg cgtggagtgg gcccgcgcct cgtccacatg cgggttgagc cgcgcgggat
    12121 acggcatgta gaagtgcggg agttcgaacg gctgcgtcat ggccgggccc tacccatgcc
    12181 tttccgggat catccggacg gcgggacatg atcacaccat cgcgtgaacc gggcccgaac
    12241 acgtgacctg cgcggaacgc gccggtgccg cgctcttgcc gggccggcga cccacgggtc
    12301 acggtggccg catgactgtg ccggacgtct tcgacccgcg ccggtacgcc gccggggtgc
    12361 cgtacgccga ctaccgcgcc ctgcgcgacc accacccggt ggcctggcag gaggagcctg
    12421 aggtgctggg ctggcccgcc gggcccggct tctgggcggt gacccggcac gcggacgtgg
    12481 tccgggtcct caaggacgcg gcgacgtact cctcgcatct cggcgcgacg cagatccgtg
    12541 acccggaccc ggacgatctg ccgttcatcc gccgcatgat gctcaaccag gacccgccgg
    12601 cgcacggccg gctgcggcgg ctggtcagcc gggccttcac gcccggccgg gtggagcggt
    12661 tcacggcggt ggccgaggag cgggcgcgca ccctgctcgg ggacgcgctg gcgcgagccc
    12721 gcgccgggga cggcaccgtc gacgtcgtcg ccgccgtcac cgacgactac gccctgctca
    12781 acctcgcgga cctgctgggc gtaccggaga gcgaccgcgg gctgctgctg cactggacgc
    12841 ggcgggtgat cggctaccag gacccggacg aggcgggccc cgaggtacgg gacacggcgg
    12901 ggagaccggt cgatccgcgg tcgccggcga tgctgcgcga catgttcgcg tacgcgcacc
    12961 ggctcgccgc gcacaagaga cggcaccccg gcgacgacgt gctgaccacc ctcgcccagg
    13021 agcgcgaact cgccgacggc gagctggaga tgttcttctt cctgctcacc gtggcgggca
    13081 acgacaccgt gcgcagcgcg gccccgggcg gtctgctgga gctggcgggg cacccggagg
    13141 cgtaccggcg gctgcggacc ggtcaagccg aactgggcgc ggccgtggag gagttgctgc
    13201 gcaggcatcc gcccgtgctg acgttccgcc gtaccgccgc ccgggacacc gagctggcgg
    13261 ggcggcggat ccgggccggg gacaaggtgg tcgtcttcca cgcctccgcc aaccgcgacg
    13321 agcgggtctt cgccgacccg gacgggctgg acctcggccg gtcgcccaac ccgcacgtgt
    13381 ccttcggcga cggcccgcac gtgtgcctgg gcgcccactt cgcccggctg caactgcggg
    13441 tgctgtaccg gcaggtgctg ctcgccctgc cggaactgcg gacggcggca ccgccgaggc
    13501 gactggtgtc gaacttcatc aacggcatca agtcgctgga gctccaggtc acttgacctg
    13561 cggttacttc tcccgcacct ggatcagcgc gtgcgtgccg ccggtgcgcc agcgctgccc
    13621 ctcggcggcg acgagcgcgg cctcggtggc cgcgtcgagg ccggtgatca cgtcggactt
    13681 cagggtgcgc agggcggcga ccggacccgg gaaatgggcg gtgacgtcgg cgaaggaggt
    13741 ggtcgggggc cacagccggt cccccaccag gcggcggtag ttgaggtcgc ccttgaggac
    13801 ggtgagcgtg tacccggcga actccgcgcg caggtcgccg ggcatcgcgg cgtacggcag
    13861 cgggcccgcg gagaaggggt gcgcccgcac ggtgagggtg ccgtcgctca gcgcctccca
    13921 caggcgccgc ccgtacgccc gggccgcacc cggggccgcg gccagccggc gcagggcgtc
    13981 gaggaggtcg gcggtggtgg cgtcggagac gtagtagggc tgcggtttca ggtgcaggac
    14041 cgcccgtgcc acgcgtccgg cgtccagcag atgggcgagg agcagcaggt cggggatgag
    14101 ttcgcgcccc gcgttgtcgg cgaccaggca cagggtgccg gcgccgccgg gcgggagcag
    14161 cgcccacagg gccgcgctgt cgtcggcgac gagggcgggc gcgacggggg tccgcggggc
    14221 gtcggcgccg gtgcccggtc cggcggcccc agcggcgccg gcggacagcc ggaatccgag
    14281 gtcggccctg ttcccccaca gcgagccgtg cagcagggcc tgggcccgct cgtcggacgg
    14341 gcgggaggtg aggtcgtcca gtgcggccag ttcctcctcc gtctcggcgg agtcgagttc
    14401 ggcgagcttg gacgggcgga acgggtcgat gccctgccag gggccgggcg tgaagtagcc
    14461 ggtcgcttcg aggagccggc ggtagaagta gctctccgcc cacagccagg gcacctcgaa
    14521 ccaggaccgg ccggtgtgct ccccgagtcc ccaggtgtgc cagcggtccc ggtcgggggc
    14581 ttcggcgggc agcggctcga tcacgccgtc ggtgcagctc tccagcagtg cgtcgagggc
    14641 gcggcggatc ccggggccgt aggggaaggc gtcccgcacc tgccggatga tcgcgggatg
    14701 ccgttcggcg agcacgctgt gcgggaaggt gccgggtgcg ccgccgacga gcacgggggc
    14761 gccgggcgtg ggagcggggc tgtcgggcat gcggctcaac ctaccgccgc ccgcgtccgc
    14821 cgggcggctc acacggccgc ggccgccatg acctcccgct ccaggcgcgt gatcagggtc
    14881 atgtagcgcg gtcggcgcgg aaccgggacc agtccgcgga cgaggacgcg ccacatctcg
    14941 gccgtcctgc gcggcagtcg ggcgacgggt tcgagggagc ggcccacgac acgggtgccg
    15001 acgaagaagg agacgaggga gtgggcgacg gcgtccacgt cgacgtccgg gtggaggtcg
    15061 gactcgcgga ccgcgctctg cagccggtgg gtgacgatct ccagccactc ggagaacggg
    15121 tgccgcaacg gctcgcgcag cggcaccggg ccggtggcga ggcggagtcc ggcccgggtg
    15181 accggtccct ccacggacag ccgggtcatg gcgaacacga tccgtatgag cgcctccagc
    15241 gacgggtagt cgtggccgtc cacctcgccg gtgacctggc gggagacctc ggactgcaac
    15301 tccatgatgg cgtgggcgag atcctccttg gccgcgaagt ggaagtagag ggcgcccttg
    15361 gtgaccttcg cgtgctggac gatgtcgctc aggctcgtcg cctcgtagcc acgctggtcg
    15421 aacaggtcgg cggccgctgt gatgatcgtc gcgcgggtct gctcggcgcg taactgcctc
    15481 ggcatcgacg ggacactcct gggacgggaa agaacgggtc atgccgtttg tttctaactc
    15541 cctgtacacg atatctcacc ggtccgccgt tgcgaccagg cattcgaaga gagtggatcc
    15601 gccctgcacg cccacgactt ggatgcctgc cgcatccgtg cgccggacct cgatccaggc
    15661 gggttcgtcc agctcagcgt agcgatggaa gcgggatcgg taggccaccg ggacccgttg
    15721 tcccgccgtg tggaccacgg tggcctggcg ggccgcctcc agcagcagcg tgcccgggac
    15781 gtgatccagc ggatggtcga agaaaacggg gtgtgcggta tctactcgca gccgccagcg
    15841 gcccctgcgg tcggcggggg cgaggacgac atcgcccggc agggcccggt cgaccgcctc
    15901 cgggggaagt cccgccggcg cgggcagggc ggtgacggtc tccggggtgc gcccggaccg
    15961 cagtcgccgg tagacggcct cactcatgca ggtgaacgcg acgtccgcgg tggcggcgcg
    16021 ctcgccgcag cgcagcacct cggcggtgta acgggcggag accgggcgcc ggccgcggta
    16081 ctgcacgtcc gtgaagacga cgtcgacctc gatctcggcg ggcagcgcgc cgaccccgag
    16141 gtgttccggg aacgtcgtca cgtcgaaggc gtcgagcacg aaccggtggc ccagcggcac
    16201 gtcgtactcg gcgtgcgtga gcagggtgcc gctctgccga accgtttcga cagcgagcag
    16261 cgggtcgtag gccgtccagt ccgccgacac gtgtaagccg tgcgcgcgcg gccactgcgc
    16321 cgctaccgtg aaacggtcgt cggccagccg gtgccagccg gtgaggaggg tttccgcgac
    16381 cgccgcgcgg tgcacgagct gacgggggac ggtcgccgtc atggccgggt tcccggccag
    16441 ctgccgcggt tgaggcatct ctctccctac gggccccgta cggtccttga gggcccggcg
    16501 ggcggcgtgg ggtccgcttc ggcgggcgct agggtacgag gcgaccggtt tgttttcaac
    16561 gagatcagtc cgtgacgccc ggtgatcagg gcgttccgta agatcgtacg ggtcgttcaa
    16621 ctgcggtgcc cgcggagggg cttacatggc aagacaggaa cgggccatcc ggactcgccg
    16681 aatgatcctg gaagccgcgg gcgcggtctt cgacgagcac gggtacgcct ccaccacgat
    16741 cgcgatggtg ctggaacggg ccgaagtcac caagggcgcc ctgtacttcc acttcccctc
    16801 caaggagtcg ctcgcccagg ccgtcctcgc cgagcaggtg ctcttcggcg cggtgccctc
    16861 gcgcagcagc aagctgcagg aggtcatcga catgaccttc gcggtggggc agcggctgcg
    16921 cagcaacgcg ctgctgcgcg gcggggtgcg gctggcggtg gaccaggaga cgccgtccgg
    16981 catcgaccgg ggggagccgt tccggcagtg gtcgcggcgg ctgacggcgc tgctggaaag
    17041 ggcggccgag cagggcgagc tgctgcccac ggtacggccc gcggacacgg tcgacctgct
    17101 ggtcggggcg ttcaccggga tccagctgat gtcgcgggcg ctgaccgacc gggccgatct
    17161 cgcggaccgg ctggcggtgc tgtgggcgca catgctgccg agcatcgcgg tgccgggtct
    17221 gctgccgggg ctggacagcc gggcggaccg gggcgtgcgg gtgctggccg agatcgatcc
    17281 ggcccaggcc ggcgcggagg ccgaggagcg gactccggcc ggggtgcggt gagcgcgtga
    17341 acgcgcggcg ggccggcnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn natccgcacc
    17401 ggccggcccg cctgttcagg gaccgctcag cggtctgtcg ctcggagggc cggcttcgtg
    17461 aagcccggcc gtccgggtca gaaggtcagc gcccagctgt tgagcgtgcc cgtgtcgtag
    17521 gacgcgacgt cctggacgcg cagcttccag gtgccgttgg ccgcctcgct ggaggcgtcc
    17581 accgtgtagg tggtgttgac gttgtccgcg gagtcggagg agctggagtt cttcagccgg
    17641 taggcggtgc cgtcgggcgc aaccaggtcg atgaccaggt cgccccggta ggtgtgggtg
    17701 atgttcaccg cgaccttcag ggtggcgggc gcgttgccgc tcaggccgct gaccgcgagg
    17761 gacgaggtga tcgcggagcc ggcgtccggg atggcgaccg cggtggagtt ggtgaaggtg
    17821 gtgccccccg tggagccgcc ggagccgctc accgcctgca cggtcttcgc cgcgtccgcg
    17881 aggccggcgc cgcagccgcc ggagcaggtg cccggcagcg ggcgggcgtt ggccttgatc
    17941 gccgactcga tctgcgccgg ggtcagggac gcgttggcgg acttcatcag cgcgaccagg
    18001 cccgcgatgt gcggggtggc catgctggtg ccctggtagt aggcgtacga ctcggtggac
    18061 ggcgtccggg tgccggagtt cagcgtggac aggatgccgt tggcggtgcc ggtgctggtc
    18121 tggccgccgg gcgcggagat gtccaccagg gagccgtagt tggagtagga ggccttcgag
    18181 ccggtgcggt tggtcgcggc gaccgagatg acgttgttgc agttgcccgg cgagtggttc
    18241 gcgacgttgt cgttctcgtt gcccgcggcc acgacgacgg tggtgccgcg gctgaccgcc
    18301 gcgttgatgg cgttctgggt ggccgaggtg caggcgccgt cgccgcccag ggacatgttg
    18361 atgaccttgg cgacgttgga gttggcgggc acgccggaga cggtgccgcc ggacgcccag
    18421 gtgatggcgt cgatgatgtc ggagtcgtag ccgccgcact tgccgaggac gcgcagcggg
    18481 gagatcttcg cgccgtaggc gatgccggcg acgcccttgc cgttgttggt gacggcggcg
    18541 atggtgccgg cgacgtgggt gccgtgccag gaggagttgc tgccggggac gttggtgccg
    18601 cactcgttgt cggcgtacca gtcgcccggg tcggccgggt tgctgtcgcg gccgtcgccg
    18661 tcgacggaga cggcggtgtc ggagatgaag tcgtatccgc cgacgatgtt ggcggccagg
    18721 tcggagtggg cgacgtagcc ggtgtcgatg acggcgacgg tgacgccgct gccggtggcg
    18781 atgtcccagg cgccgggcac gcgcatgccg gcggtctcct cgaacaggtc ccactgcttg
    18841 ccgtactcgg tgtcgttcgg cgtggccatc ggcttgttga ggcggtccgg cacgacgtag
    18901 gcgacctgcg ggtcggccct gaactcggcg accacgtcgg cgacgtccgc gcgggtggcg
    18961 cgcgcgccga ggtcgacgag ggcggcgccg gtgccgaggc ggcgccggaa gtcggcgtcc
    19021 gttccggcct ccttgccctt ggcggcggcg tcggcctcgg cggcccggtt ggaggtggcc
    19081 tcctcggcgc ccggcttgta accgacgatg agccgctcgg cgggcacgcc cggtgcggcc
    19141 tcggtctggg cggcgggaac ggcggcctcg gccgtggggg cctgcggggc ggcggcgacc
    19201 gcggcggtgg cggccgtgag cagggccgcg gagaccgcgg cgacggatat cagcttccgt
    19261 ccggtggcgt ggggtgtacg caagggcttt gcctttcgtg gccgattccg cgcagggcgg
    19321 agcggcgggt ggacgcgctt cgtcgtcgaa gcggaggggg gtgtgccgaa aagcggcgcg
    19381 atggccggcc gtgcgcgggt cgccgtccca ccggggttac ctgtgggtca gctgtgcagg
    19441 aacgataggc aaaccgcagg tcgcggggat acagaggaaa ccctcgatct ggccggaaac
    19501 tccccctgcc ctacggcggg ttgggcgggt tttacggccc ttcgtcaccc tccgggcggc
    19561 cggtgccggc cgttgaacgc acggaaccgg atgcccgtac tgatgggtgc aggccatgcc
    19621 cctcccccgg ccgaggagac ctccccgatg ccccggaaga ccacgccccg ccgccgtacc
    19681 gccctggcgg ccaccgccgc cgctcccctg ctgctcgggc tgtgggcggc gggcccggcc
    19741 ggggcgcacg gcgcgccgac ggacccggtg agccgggtgt acgcctgctc gccggagggc
    19801 ggcgcggcgg cccggtcggc ggcgtgccgg gcggcggtcg cggcgaacgg cgggacgccc
    19861 ttcacggcgt gggacaacct gcgggtggcg gacgtcggcg gccgggaccg ccgggtgatc
    19921 ccggacggtg agctgtgcag cggcgggctc gccgcctacc gcggcctgga tctcgcccgc
    19981 acggactggc cgtcgacacg gctgacgccg gggaccacgg tgacgctgcg gtacgcctcg
    20041 acgatcccgc acaccggcac gttccggctc tatctcaccg aggccggcta cgacccgtcc
    20101 cggccgctga cctggtcgga cctgcccgag cggcccctcg ccgaggtcaa ggacccgccg
    20161 ctgacggacg gggcgtaccg catcccggtc aggcttccgg cggaccgcac cggacgccat
    20221 gtgctgtaca cggtctggca gaacagcagc acgccggaca cctattactc gtgttccgac
    20281 gtggtgttgg cgggaggtgc gccaacgagg ccgaagccgt cccaggcggc ccctgccgcc
    20341 ggcccgaagc cgtccggcgc aacccccgcc ggcacgacgc ccgcgagcac gacccctgcc
    20401 ggcacgacac ccgcgagcac gccccccgcc ggcaccgcgc ccgcaccgac cgctgtcgtc
    20461 ggcgctgccc gtacggccgc ggacaccggc ggcgcctcct tcgcccccgg tgccccgctg
    20521 ctcgcgggcg gcgccgccgc ggtgctgctg ctcaccgggg gcgccgccct ggccgtacgg
    20581 ctgcgcaggc gctgaactga ccggcttggt cgctcagttg acgtagacgg cggcgcctcc
    20641 ggtcgtcacc ggggcgtact tcgcggtgaa gtaggcgttc gagaagcaca gggacgagcc
    20701 ggagatcttc gtgaagtgct ggtcgtcgaa cgtgatggag ttgtcggcgt tgctcgcggt
    20761 gccggacagg cccgggccct ggtagacaca ggtgacggtg ccgagcaggg tgcgcagctt
    20821 gacggtggtc tgcacggtgg agccggccgg cggggtgaca tcgagcgcgc ccgcggaggt
    20881 cacggtggcg gtgtagggca ggtggtcgac ggtgatgccg ctgacgccga gcaccccggt
    20941 gacgttgctg gtgcagctcg ccgcgtcgaa ggtgtgggcg gtcacggact cggtggccgt
    21001 gccgggcgcg ctggggttgc cggtgacggt ggcggtgaac tgcgaggacg tgcagcgcag
    21061 accgctggtg ccgtcggcgc tggagtagaa ggtggcggcg gtgccgctcg ccagggaggc
    21121 ggtgaggacg gagccggtgg cgaccggggt gccgcccgcg ccgccggtgg tgaggaccgc
    21181 ggtgtcggcg gcggaggccg gcagggtggc ggggagcgcg agggcgacga cggctccggc
    21241 gacggtgagc aggctgcgag tacgcatgcg ggtgcctctt tctcaggaag tgggggtcga
    21301 acgagggctg cacgcaggac gcccgtcgtg cgcccggccg aagggcgtgg ggggtgtggg
    21361 gagaccttcg gccgggccgg gcggaaaggg cttgtgccgg acgatgtgtg gcggcgcgcc
    21421 acgggcatgc cgggcgcagt ggatccggcg ccacggatcc gggctgacgt agcagagttg
    21481 tagacctgaa tttctgtcaa cgtcaaggct tcacagggaa gttgaagtac gtgcacggat
    21541 catgcacaac acccttgacc cccgactgta accatcggta acttccgatt ggctactacc
    21601 gcgtaacacg aaagcccttg cggcccacgg aaggtgcgga gggcgggcgc ggcagtcgcc
    21661 gtccgcgcca ggacatcgcg tcagtgcacg tcagtgaagg tcagcgcact ccatcacccc
    21721 gcgttcacca tgcttacggg agcagacatg gaaagcggtt ccgcagccag cgcaccggaa
    21781 gagacggcgg gcagcgcccc ggaggacacc gaaagacgcg gccgggtccg gctgcggcgc
    21841 gccgccgtgc tcgcggtgcc cgcgaccctg gtcgccgccg gcctcgcggt cctcaccgcg
    21901 cagggcgccc tcggcgtgca gttcgccatc tccggcatgc cgttcaccgt caccgccacc
    21961 gacctcgaag ggaccggctt cgagcagttc ggcgcgctgg acaacatggc ggagggcagc
    22021 cccaacgccg gtgacaccgg cggtcaggtg ctggtcgtca cctccgcgat caagaacgcc
    22081 accctgacca agctgtgcca gagcgtcgac ctcggcggca ccaacctgct gatcaccgcg
    22141 ggcggcggca aggacaaggt
//
