LOCUS       NZ_BNBR01000001        26754 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000001
VERSION     NZ_BNBR01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 2104813)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1146374
            Orig. end                         :: 1173128
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26754
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26754
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26754
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16754](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16754)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(601..1494)
                     /locus_tag="IE308_RS05055"
                     /old_locus_tag="GCM10018783_10350"
     CDS             complement(601..1494)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386177.1"
                     /locus_tag="IE308_RS05055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10350"
                     /product="peptidoglycan DD-metalloendopeptidase family
                     protein"
                     /protein_id="WP_190216744.1"
                     /transl_table=11
                     /translation="MPAKGKHRRPKAQRFTRSIAVAGTGGAALALPLLGATGAHAATPQ
                     SAPDKAVQSAPVAAGKTAATKTGVRTYTVRSGDYLSKIAQTQHVSGGWKKLYADNREAI
                     GSDPSLIHPGLKLTLGKKAAASTNAERPARKPAAKSSAPKAQQSAAKAAPAAQAAPVTG
                     FSLPVSGATVGTPYHLAGSMWSSGYHTGVDFVVPTGTSLKAVAAGTVVSAGWGGAYGNQ
                     VVIKLNDGYYAQYAHLSQLSVSAGQTVTAGQQIGLSGATGNVTGPHLHFEIRTTPDYGS
                     DVDPVAYLRSHGVSVG"
     regulatory      complement(1499..1658)
                     /bound_moiety="cyclic di-AMP"
                     /db_xref="RFAM:RF00379"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00379"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cyclic di-AMP (ydaO/yuaA leader) riboswitch senses
                     the signaling molecule cyclic di-AMP; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(1768..1782)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     misc_feature    1788..1801
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.75"
                     /tool="antismash"
     gene            2150..2947
                     /locus_tag="IE308_RS05060"
                     /old_locus_tag="GCM10018783_10360"
     CDS             2150..2947
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069689.1"
                     /locus_tag="IE308_RS05060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10360"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_190216745.1"
                     /transl_table=11
                     /translation="MTQQVPSTEPELAGVRNFRDVGGLPTVDGRRVRHGVLFRSGHLAH
                     ATQEDAAFLSSLGLHTIFDFRNAADQKLEGPDVALPGVRNVNLPLSDPADGAEFWKMVR
                     DGDIEQLRGILGDGRAAARMIASYRQIIKERTAEHSRVLHALAEDSVPALMHCAAGKDR
                     AGLSIAVTLLALGVEREAIIADYLESNAKHRRYKVHRSNGSGDAYSPEVMELLSPLFDA
                     RAEYLTAAFETIEQTWGDVDTYLEQGLGLAPATRERLRERLLD"
     gene            complement(2972..3094)
                     /locus_tag="IE308_RS05065"
                     /old_locus_tag="GCM10018783_10370"
     CDS             complement(2972..3094)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009329167.1"
                     /locus_tag="IE308_RS05065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10370"
                     /product="DUF6126 family protein"
                     /protein_id="WP_190216746.1"
                     /transl_table=11
                     /translation="MNDREERFPRTLWIRLIIYIAVGHVLAAFIWLLFEVGANQ"
     gene            complement(3091..3714)
                     /locus_tag="IE308_RS05070"
                     /old_locus_tag="GCM10018783_10380"
     CDS             complement(3091..3714)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494121.1"
                     /locus_tag="IE308_RS05070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10380"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_190216747.1"
                     /transl_table=11
                     /translation="MSSSDGPPDGPAPEGLPTVAPQLRALRRRAGLTLEAAARAAGLSP
                     AHLSRLETGQRQPSLPMLLALARIYGTTVSELLGETVAERDAVVRHADMEPTAAGGWTY
                     WQAGAPGRGMQALRVRVPYGSQGDIVRVHPGEEWLYVLAGRLVLRLGDTTHRLAPGDSA
                     HFDSLTPHRIAAQDEGGAELLFVHTLLQSPTATLCLGHTPGETS"
     misc_feature    complement(3720..3740)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            complement(3777..5198)
                     /locus_tag="IE308_RS05075"
                     /old_locus_tag="GCM10018783_10390"
     CDS             complement(3777..5198)
                     /NRPS_PKS="Domain: Aminotran_3 (53-375). E-value: 6e-89.
                     Score: 290.3. Matches aSDomain:
                     nrpspksdomains_IE308_RS05075_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044658.1"
                     /locus_tag="IE308_RS05075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10390"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_190216748.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.2e-88, bitscore:
                     292.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAKSASPSPSQAGGFDLAALLAARGAERYELHGKYLNHQLPRM
                     LHTIGFDKVYERAEGAHFWDADGNDYLDMLAGFGVMGLGRHHPVVRQALHDVLDLNLAD
                     LTRFDCQPLPGLLAEKLLAHSPHLDRVFFGNSGTEAVEGALKFARYATGKPRVLYCEHA
                     FHGLTTGSLSVNGESGFRDGFAPLLPDTAVPLGDLDALARELRKGDVAALIVEPIQGKG
                     VHEAPPGYLRAAQELLHRHKALLIADEVQTGLGRTGDFYAYQHEDGVEPDLVCVAKALS
                     GGYVPVGATLGKDWIFKKVYSSMDRVLVHSASFGSNAQAMAAGLAVLSVMENEQTVANA
                     RAMGELLKSRLTALIGKYELLADVRGRGLMIGIEFGKPKSLKLRSRWTMLQAARKGLFA
                     QMVVVPLLQRHRILTQVSGDHLEVIKLIPPLVIDEADVDRFVDAFTAVMDDAHSGGGLM
                     WDFGKTLVKQAVANR"
     aSDomain        complement(4074..5039)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS05075_Aminotran_3.1"
                     /evalue="6.00E-89"
                     /label="IE308_RS05075_Aminotran_3.1"
                     /locus_tag="IE308_RS05075"
                     /protein_end="375"
                     /protein_start="53"
                     /score="290.3"
                     /tool="antismash"
                     /translation="VYERAEGAHFWDADGNDYLDMLAGFGVMGLGRHHPVVRQALHDVL
                     DLNLADLTRFDCQPLPGLLAEKLLAHSPHLDRVFFGNSGTEAVEGALKFARYATGKPRV
                     LYCEHAFHGLTTGSLSVNGESGFRDGFAPLLPDTAVPLGDLDALARELRKGDVAALIVE
                     PIQGKGVHEAPPGYLRAAQELLHRHKALLIADEVQTGLGRTGDFYAYQHEDGVEPDLVC
                     VAKALSGGYVPVGATLGKDWIFKKVYSSMDRVLVHSASFGSNAQAMAAGLAVLSVMENE
                     QTVANARAMGELLKSRLTALIGKYELLADVRGRGLMIGIEF"
     gene            complement(5195..7132)
                     /gene="dxs"
                     /locus_tag="IE308_RS05080"
                     /old_locus_tag="GCM10018783_10400"
     CDS             complement(5195..7132)
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996254.1"
                     /locus_tag="IE308_RS05080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10400"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_190216749.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 3.6e-112,
                     bitscore: 370.8, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-06, bitscore:
                     25.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILENIRGPRDLKALSEAELGELTEEIREFLVHAVARTGGHLGP
                     NLGVVELTVALHRVFESPVDRILWDTGHQSYVHKLLTGRQDFSKLRGKGGLSGYPSREE
                     SEHDVIENSHASTALGWADGLAKARQVQGGKGHVVAVIGDGALTGGMAWEALNNIAAAK
                     DRPLIIVVNDNERSYAPTIGGLANHLATLRTTDGYEKVLAWGKEVLQRTPVVGGTVYEA
                     LHGAKKGFKDAFAPQGLFEDLGLKYVGPIDGHDIKAVESALRRAKRFHGPVLVHCLTEK
                     GRGYEPALAHEEDHFHTVGVMDPLTCEPLVPAGGPSWTSVFGEEMVRIGEERDDVVAIT
                     AAMLHPVGLGTFAARFPDRVWDVGIAEQHAVVSAAGLATGGLHPVVAVYATFLNRAFDQ
                     LLMDVALHRCGVTFVLDRAGVTGVDGPSHNGMWDMSILQVVPGLRIAAPRDADQLRAQL
                     REAVAVDDAPTLVRFPKESAGPSIPAVDRVGGLDVLHRAERPEVLLVAVGVMAPVCLQA
                     AELLEARGIGCTVVDPRWVKPVDPALPGLAARHRLVAVVEDNSRSAGVGSAVALALGDA
                     DVDVPVRRFGIPEQFLAHAKRGEVLADIGLTPVEVAGRISASLAVKDIGAHAEGTGPAA
                     EEEPSKEKQA"
     gene            complement(7164..8327)
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="IE308_RS05085"
                     /old_locus_tag="GCM10018783_10410"
     CDS             complement(7164..8327)
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity (ferredoxin) [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031167.1"
                     /locus_tag="IE308_RS05085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10410"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_110633419.1"
                     /transl_table=11
                     /translation="MTAISLGVPEVPVRPVAERRVSRRIQVGPVAVGGGAPVSVQSMTT
                     TRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQPKYV
                     FAAIEAGCAAVRVNPGNIKKFDDQVREIARAAKDHGTPIRIGVNAGSLDKRLLEKYGKA
                     TPEALVESALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAG
                     PAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPVEEVKVGIQILQSLGLRQRRLEIVSC
                     PSCGRAQVDVYKLADEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQI
                     FVKGEVVKTVPESKIVETLIEEAMKIAERMEREGTAPDPGKPAVTVS"
     gene            complement(8332..9354)
                     /gene="hpnH"
                     /locus_tag="IE308_RS05090"
                     /old_locus_tag="GCM10018783_10420"
     CDS             complement(8332..9354)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386169.1"
                     /locus_tag="IE308_RS05090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10420"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_110633416.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-19, bitscore: 67.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 2.8e-09, bitscore: 33.5,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSIKVATYLAEQKLRKRDKFPLIVELEPLFACNLKCEGC
                     GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKKKYVF
                     LCTNAMLLRKKIDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGF
                     RVTTNSTFFNTDTPQTIIEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL
                     FKKAFAGGNRRKWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELIEETDWDKYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRAMRETVSGNRE
                     "
     gene            complement(9360..10001)
                     /locus_tag="IE308_RS05095"
                     /old_locus_tag="GCM10018783_10430"
     CDS             complement(9360..10001)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431357.1"
                     /locus_tag="IE308_RS05095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10430"
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_110633413.1"
                     /transl_table=11
                     /translation="MSTQPAPAPLLIACALGIEHLALRRRDRGETGGPVTVLRTGMGPR
                     AAERSVARLLADPAFADAAVLATGFCAGLAPGMHPGDLVVAEETRDPRSTVACVGTELL
                     VKELARILPGRTVHTGPLTGSDHVVRGPERSALRATGAIAVDMESAATLLSAVRSGERP
                     VAAVRVVVDAPEHELVRIGTVRGGISAFRVLRSVLPAFYEWHRNVLLPRR"
     gene            complement(10001..12049)
                     /gene="shc"
                     /locus_tag="IE308_RS05100"
                     /old_locus_tag="GCM10018783_10440"
     CDS             complement(10001..12049)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031166.1"
                     /locus_tag="IE308_RS05100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10440"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_110633410.1"
                     /sec_met_domain="T2TS (E-value: 9e-152, bitscore: 503.1,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSTGALPPRAAAASETRTDIPAAAGVPDVPDAARRAVAR
                     ATDFLLARQDAEGWWKGDLETNVTMDAEDLLLRQFLGILDEATAQAAALFIRGEQREDG
                     TWATFYGGPGELSATIEAYVALRLAGDAPDAPHMAKASAWIRAQGGIAAARVFTRIWLA
                     LFGWWKWEDLPELPPELIFFPTWVPLNIYDFGCWARQTIVPLTIVSAKRPVRPAPFPLD
                     ELHTDPAHPNPVKPLAPVASWDGAFQRLDKALHALRKVAPKRLRRAAMNTAARWIIERQ
                     ENDGCWGGIQPPAVYSIIALHLLGYDLQHPVIREGLASLERFAVWREDGARMIEACQSP
                     VWDTCLATIALVDAGLPTDHPQLVKAADWMLGEEIVRPGDWAVRRPGLPPGGWAFEFHN
                     DNYPDIDDTAEVVLALRRVRHHDPDRVEGAIARGVRWNLGMQSKNGAWGAFDVDNTSPF
                     PNRLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAHDPRTRRGIEWLLAEQEPDGSWFGR
                     WGVNYIYGTGSVVPALVAAGIPASHPAVRRAVAWLESVQNDDGGWGEDLRSYKDARKWA
                     GRGASTASQTAWALMALLAAGEKESKAVERGVAWLAATQREDGSWDEPYFTGTGFPWDF
                     SINYHLYRQVFPLTALGRYLNGDPFAGRLPAPGARAADRPRAEAKGM"
     misc_feature    12155..12170
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.62"
                     /tool="antismash"
     misc_feature    complement(12158..12173)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.27"
                     /tool="antismash"
     gene            complement(12166..13302)
                     /locus_tag="IE308_RS05105"
                     /old_locus_tag="GCM10018783_10450"
     CDS             complement(12166..13302)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656372.1"
                     /locus_tag="IE308_RS05105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10450"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_190216750.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.3e-58, bitscore:
                     194.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGERGAAGSRTPGTATRGETVPTVPPAETAARRTAVDVTALLER
                     GRTLATPVLRTAVDRLAPPMDTVAAYHFGWIDAQGNPTAGDGGKAVRPALAVLSAEVTG
                     AAPETGVPGAVAVELVHNFSLLHDDLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALA
                     NEVLLELGTVEAGRAARRLTTATRALIDGQAQDISYEHRDRVSVDECLEMEGNKTGALL
                     ACASSIGAVLGGADDATADALEKYGYHLGLAFQAVDDLLGIWGDPEATGKQTWSDLRQR
                     KKSLPVVAALAAEGPAAARLGELLAADAKSSDFENFSEEEFAARARLIEEAGGRDWTAE
                     EARRQHTIAIEALDAVDMPEQVRARFTALADFVVVRKR"
     gene            complement(13302..14729)
                     /gene="hpnE"
                     /locus_tag="IE308_RS05110"
                     /old_locus_tag="GCM10018783_10460"
     CDS             complement(13302..14729)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116598.1"
                     /locus_tag="IE308_RS05110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10460"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_190216751.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-07, bitscore:
                     28.3, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 9.1e-13, bitscore: 45.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDGTRSDGPPHHAARPGRDAVVIGGGLAGVTAALALADAGVRVT
                     LLEGRPRLGGLAFSFRRGALTVDNGQHVYLRCCTAYRWFLDRIQAADLAPLQSRLDVPV
                     VDAGKPEGRRLGRLRRDALPVPLHLGRSLATYPHLSLAERAKVGRAALALKGLDLTDPA
                     LDDQDFGSWLAAHGQSARAVEALWDLVGVATLNAVAGDASLGLAAMVFKTGLLSDPGAA
                     DIGWASVPLGDLHDRLARKALETAGVRIGLRTRVTSISIDENGRWSVQVPGDTLTADAV
                     VLAVPQRETYDLLPPGALDAPERLLDIGTAPILNVHVVYDRPVLHAPFFAALGTPVQWV
                     FDRTEASGLSGGGQYLALSQSAAQDDIDRPVAELRERYLPELGRLLPHTRHAEVLDFFV
                     TRERTATFAPTPGVGRLRPGARTKAPGLYLAGAWTATGWPATMESAVRSGVSAAEAALG
                     ALGRPRPRHLFAFEEAA"
     gene            complement(14726..14854)
                     /locus_tag="IE308_RS37415"
     CDS             complement(14726..14854)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039420.4"
                     /locus_tag="IE308_RS37415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6380 family protein"
                     /protein_id="WP_373314432.1"
                     /transl_table=11
                     /translation="MDSTSEGGMRHATLRCGAASLTATACRTAFTHLGGRAGEGVR"
     gene            complement(14854..15804)
                     /gene="hpnD"
                     /locus_tag="IE308_RS05115"
                     /old_locus_tag="GCM10018783_10470"
     CDS             complement(14854..15804)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431361.1"
                     /locus_tag="IE308_RS05115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10470"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_110633403.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.4e-56, bitscore:
                     188.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 7.7e-71,
                     bitscore: 235.5, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTVELPPPASAPVLAAYSYCEAVTGQQARNFAYGIRLLPTHKR
                     RAMSALYAFSRRVDDIGDGALSNDVKVARLEDTRALLTRIRAGEVEEDDTDPVAVALAH
                     AAEHFPIPLGGLDELIDGVQMDVRGETYETWDDLKVYCRCVAGAIGRLSLGVFGTEPGA
                     RGAERAPEYADTLGLALQLTNILRDVREDAQGGRTYLPADDLAKFGCSAGFDGPTPPQG
                     SDFAGLVHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLR
                     GRVSLPGHEKAYVAVRGLSGLDARNVSRQTVRRRA"
     gene            complement(15801..16754)
                     /gene="hpnC"
                     /locus_tag="IE308_RS05120"
                     /old_locus_tag="GCM10018783_10480"
     CDS             complement(15801..16754)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527751.1"
                     /locus_tag="IE308_RS05120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10480"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_229908706.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.2e-40,
                     bitscore: 135.5, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 6e-40, bitscore:
                     133.9, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCRPRPGQRAVTGTTAGVGTARPAHAGDPGHGTLAKAADENFPVA
                     PFFLPRAWRADLMAVYGFARLVDDIGDGDLAPGGADARLLGVAPGEAQDRLVLLDAFEA
                     DLWRVFDGTPRHPLLRRLQPTVRRCSLTPEPFLGLIAANRQDQLVSRYETFDDLLAYCE
                     LSANPVGRLVLAVTGTSTPERIRRSDAVCTALQIVEHLQDVAEDLGRDRIYLPAADMKR
                     FHVQEADLAAKTAGASVRALVAYEAQRARDLLNEGAPLVGSVHGRLKLLLAGFVAGGRA
                     ALGAIAAADYDVLPGPPRHGKLRLLREVGVTLRGEG"
     misc_feature    17018..17033
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.84"
                     /tool="antismash"
     gene            complement(17086..17874)
                     /locus_tag="IE308_RS05125"
                     /old_locus_tag="GCM10018783_10490"
     CDS             complement(17086..17874)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330378.1"
                     /locus_tag="IE308_RS05125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10490"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190216753.1"
                     /transl_table=11
                     /translation="MAEQRTDARVPTVIADDVHIVYRVNGGGGGKGSATAALSRILKRG
                     SDEAARGVRKVHAVRGVSFVAYRGEAIGLIGSNGSGKSTLLRAIAGLLPPESGKVYTDG
                     QPSLLGVNAALMNDLTGERNVILGGLAMGMSREEIKERYQDIVDFSGINEKGDFITLPM
                     RTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDAKFQKRSEERIRELRKEAGTVFLVS
                     HSNKSIRDTCNRVLWLERGELRMDGPTEEVLKEYEKFTGK"
     gene            complement(17867..18796)
                     /locus_tag="IE308_RS05130"
                     /old_locus_tag="GCM10018783_10500"
     CDS             complement(17867..18796)
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994380.1"
                     /locus_tag="IE308_RS05130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10500"
                     /product="ABC transporter permease"
                     /protein_id="WP_190216754.1"
                     /transl_table=11
                     /translation="MSETTHDDPVTLSGAASPDEGLTAAELAARYGLSVSGARPGLGEY
                     VRQLWGRRHFILAFSQAKLTAQYSQAKLGQLWQVATPLLNAAVYFFIFGVILKADRGMA
                     REVYIPFLVTGVFVFTFTQSSVMAGVRAISGNLGLVRALHFPRASLPVSFSLQQLQQLL
                     FSMIVLFLVAAGFGSYPDLSWLLIVPVLALQFLFNTGLALIMARAGAKTPDLAQLMPFV
                     MRTWMYASGVMFSIPVMLADKPDWVTTALQWNPAAIYMDLMRFALIDGYGSSNLPPHVW
                     AAAVGWAVLFAAGGFVYFWKAEERYGRG"
     misc_feature    complement(18756..18769)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    18791..18806
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.87"
                     /tool="antismash"
     gene            complement(18915..19799)
                     /locus_tag="IE308_RS05135"
                     /old_locus_tag="GCM10018783_10510"
     CDS             complement(18915..19799)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972240.1"
                     /locus_tag="IE308_RS05135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10510"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_190216755.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.3e-12,
                     bitscore: 43.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPVKVGAVVITMGNRPGELRALLESVAAQDGDPVEVVVVGNGS
                     PVPDLPAGVRTIELPENLGIPGGRNAGIEAFGPGGRDVDILLFLDDDGLLARTDTAELC
                     RQAFAADPRLGIISFRIADPASGVTQRRHVPRLRAADPMRSSRVTTFLGGANAVRTAVF
                     QQVGTLPEEFFYAHEETDLAWRALDAGWMIDYRSDMVLYHPATAPSRHAVYHRMVARNR
                     VWLARRNLPAPLVPVYLGVWLLLTLLRRPRVAALRAWFGGFREGWTTPCGPRRPMKWRT
                     VWRLTRLGRPPVI"
     gene            complement(19796..20575)
                     /locus_tag="IE308_RS05140"
                     /old_locus_tag="GCM10018783_10520"
     CDS             complement(19796..20575)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413838.1"
                     /locus_tag="IE308_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10520"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_190216756.1"
                     /transl_table=11
                     /translation="MSRPSVAELRPVVHPAGVKDRRSGEHWMGRLYMREVSLRVDRYLV
                     NTRVTPNQLTYLMTLCGVLAAPALLVPGVWGAVLGVVMVQLYLLLDCVDGEIARWKKQY
                     SLGGVYLDRVGAYLTDAAVLVGLGLRAADLFGSGRIDWLWAFLGTLAALGAILIKAETD
                     LVGVARHQAGMPPVKEVAAEMRSSGMALARRAAAALKFHRLILGIEASLLILVLAIADH
                     VRGDLYFTRLGTAVLAGIAMLQTVLHLVSVLASRRLK"
     gene            complement(20553..21614)
                     /locus_tag="IE308_RS05145"
                     /old_locus_tag="GCM10018783_10530"
     CDS             complement(20553..21614)
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494151.1"
                     /locus_tag="IE308_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10530"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_110633389.1"
                     /sec_met_domain="Fe-ADH (E-value: 5.8e-25, bitscore: 84.6,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 2.2e-08, bitscore:
                     30.3, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLLTRLIPSPVVVDIRPGALDDLGNVLADERISHSGRLAVAVSG
                     GSGARLRERIAPSLPGADWYEVGGGTLDDAIRLAGEMKAGHYDAVVGLGGGKIIDCAKF
                     AAARVGLPLVAVPTNLAHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIREAPVRF
                     VRAGIGDAISNISAIRDWELANRVNGEKIDGLAAAMARQAGEAVLRHPGGIGDNDFLQV
                     LAEALVLSGIAMSVSGDSRPSSGACHEINHAFDLLFPKRAAAHGEQCGFGAAFAMWLRG
                     APEESVFMTEVLRRHGLPVRAEDFGFSAEEFVKVVEFAPQTRPGRYTILEHLDLTTEQI
                     KDTYADYVKAIGS"
     gene            complement(21602..22354)
                     /locus_tag="IE308_RS05150"
                     /old_locus_tag="GCM10018783_10540"
     CDS             complement(21602..22354)
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983099.1"
                     /locus_tag="IE308_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10540"
                     /product="sugar phosphate nucleotidyltransferase"
                     /protein_id="WP_190216757.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.4e-10, bitscore:
                     37.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGPAGNEDSITVLDLTLG
                     NFAEIGLTEVAIIVGYRKEAVYERKEALEQKYGLKLTLIDNDKAEEWNNAYSLWCGRDA
                     LKDGVILANGDTVHPVSVEKTLLAARGDGKKIILALDTVKSLADEEMKVVVDPEKGVQK
                     ITKLMDPAEATGEYIGVTLIEGDAAAELADALKTVWETDPQQFYEHGYQELVNRGFRID
                     VAPIGDVQWVEIDNHDDLARGREIACLY"
     gene            complement(22351..24189)
                     /locus_tag="IE308_RS05155"
                     /old_locus_tag="GCM10018783_10550"
     CDS             complement(22351..24189)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431369.1"
                     /locus_tag="IE308_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10550"
                     /product="DUF5941 domain-containing protein"
                     /protein_id="WP_190216758.1"
                     /transl_table=11
                     /translation="MPTAILTGQPVPGSSIEGDLRALGFEVRPATDAAHAETLLARVPE
                     EDRVAVVDARFVGHVHALRLALTDPRFALAAIPGAVSARAAGRQALTRAMAREHSATGT
                     DAVPGAGDGTAVVVDGLADRITAALDADGADVHRPALGSLVAAVPADPQARNEARQAVA
                     AVDEEAVRLKSAVKSGDGLFTTYCISPYSRYIARWCARRGLTPNQVTTASLLTALIAAG
                     CAATGARGGFVAAGVLLIASFVLDCTDGQLARYSLQYSTLGAWLDATFDRAKEFAFYAG
                     LALGATHGGTDDVWALALAAMVLQTTRHMVDFAFIEAQQDADATSAAAPTAALSERLDG
                     VGWSVWVRRVIILPIGERWAMIALLTALTTPRVTFCALLAWMAFATLYTTAGRVLRSVT
                     RKARRTDRAAQALADLADDGPVVQLLVRLVPATGPRVAPLAAALGAAAVVLAAWSWGPS
                     WWVVLLAGLYTLCAAEAVSRPLTGPLDWLVPPLFRAGEYGTVLVLAATSGVNGVLPAAF
                     GLVAAVAYHHYDTVYRIRGNAGAPPAWLVRATGGHEGRTLLVTVLAALLTAPQFEVALT
                     ALAVAVAVLVLAESIRFWVAAHQGGAPAVHDEGETA"
     misc_feature    24385..24399
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.79"
                     /tool="antismash"
     misc_feature    complement(24517..24531)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.72"
                     /tool="antismash"
     gene            24604..25542
                     /locus_tag="IE308_RS05160"
                     /old_locus_tag="GCM10018783_10560"
     CDS             24604..25542
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009339288.1"
                     /locus_tag="IE308_RS05160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10560"
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_110633381.1"
                     /transl_table=11
                     /translation="MGAGHDHGHTHAAPAGGTAAAAYRGRLRVALGITVTVMVVEIVGG
                     LVADSLALIADAAHMATDAVGLGMALLAIHFASRPAGANRTFGYARAEILAALANCLLL
                     LGVGGYVLYEAVQRFLTPAGTEGSLMVVFGAIGLAANTLSLTLLMRGQSESLNVRAAFL
                     EVAADALGSLAVIVSAAVILATGWQAADPIASLVIGVMIVPRTLKLLRETLDVLLEAAP
                     KGVDMDEVRAHIVALDGVEDVHDLHAWTITSGMPVLSAHVVVRSDVLNAIGHEKMLHEL
                     QECLGGHFDVEHCTFQLEPVGHAEHEARLCH"
     gene            25697..26293
                     /gene="idi"
                     /locus_tag="IE308_RS05165"
                     /old_locus_tag="GCM10018783_10570"
     CDS             25697..26293
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129457.1"
                     /locus_tag="IE308_RS05165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_10570"
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_110633378.1"
                     /transl_table=11
                     /translation="MPITPATAAHSSSANGTADAILLELVDENGVTIGTAEKLTAHQPP
                     GQLHRAFSVFLFDDRGRLLLQQRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTFEE
                     LGVSPSLLAEAGTVRYNHPDPASGLVEQEFNHLFVGLVQTPPRPDPEEVGATAFVTAAE
                     LAERHARDPFSAWFMTVLDAARPAIRELTGPSAGW"
ORIGIN
        1 ggtgctgggt gcctccaacc acccggcgtg gcgcatggaa cgggcccgcg cgctcgcccg
       61 gcgcaacggc tggaccggct acacctgcgt gcagcagcgg tattcctacc tccagccgcg
      121 gttcgacgtc gccctgcccg agggcggcca tgtccatgtg acgccggaga tgctggacta
      181 cgtgcgcagc gagcccgatc tgacgctgat ggcgtactcg acgctgctgt tcggcgcgta
      241 ctcccgggac gacaagccgc tctcgccggc ctacgaccat cccggcaccg cccgtcgcct
      301 ggccgccgtg cgcgcggtgg ccgccgagct gggcgcgacg ccgggccagg tggtgctggc
      361 gtggctgctc ggcggtgacc cggccgtcct gccgatcgtg ggcgtcagct cggtcgcgca
      421 gctggaggag ctgctcggcg ccctggagct gacgctggac ccggagcagc gggaccggct
      481 cgaccgcgcc tgagagccgt gcgcagacgg gccgaaggcc ggacccaggg gaagaggtcc
      541 ggccttcggc ggcgcgtgtc gggcaggggg tggcgtcggt gagcagcccc ctggccgggg
      601 tcagccgacc gagacgccgt gcgagcgcag gtaggcgacc gggtccacgt cggagccgta
      661 gtccggcgtg gtgcggatct cgaagtgcag gtgcgggccg gtcacgttgc cggtggcgcc
      721 cgagaggccg atctgctggc ccgcggtcac ggtctgtccg gcggagacgg acagctgcga
      781 caggtgggcg tactgggcgt agtagccgtc gttcagcttg atgacgacct ggttgccgta
      841 cgcaccgccc cagcccgcgg agacgacggt gcccgcggcg acggccttga gcgaggtgcc
      901 ggtcgggacg acgaagtcga cgccggtgtg gtagccgctg gaccacatgc tgcccgccag
      961 gtggtacggc gtgccgacgg tggcgccgct cacggggagg ctgaagccgg tgacgggggc
     1021 ggcctgggcg gccggcgccg ccttggcggc ggactgctgc gccttcggcg ccgaggactt
     1081 ggcggccggc ttcctcgccg gacgctcggc gttcgtggag gccgccgcct tcttgccgag
     1141 ggtgagcttc aggccggggt ggatcagcga cgggtcgctg ccgatggcct cgcggttgtc
     1201 ggcgtacagc ttcttccagc cgccactgac gtgctgcgtc tgggcgatct tcgagaggta
     1261 gtcaccggac ctgaccgtgt aggtacgcac gccggtcttc gtcgcggccg tcttcccggc
     1321 ggcgacggga gccgactgca cggccttgtc cggggcggac tgcggggtgg ccgcgtgggc
     1381 gccggtggct cccaggagcg ggagggcgag cgcggcgcca ccggtaccgg cgacggcgat
     1441 ggaacgggtg aaacgctgag ccttgggacg acggtgctta cccttcgcgg gcatggcgaa
     1501 ttcctctccg gcgcctgcga ggtgagctgt cgggtgcgga ctggagatgt ccggccgcgc
     1561 ttttcggcgc gactaaaccc caagccgttc cgggaaccgg aacaggcggt cgtacctgtg
     1621 ggtcccccgc tcctgccggg cacgggtgag tgtgtgcggg ccccgggcgg cggcaggatt
     1681 cggcgttccg cccggatcgg tgtggaacgt aagcgagcaa gacgcacgga aacaagcgcg
     1741 gggttccaca tacgccgatt tcacgtgatc gacaggcgga atcgccggtc accctgcgtg
     1801 tattccgtac cgcttcgctc tgccaattcc ccagcagaat ggcaggtatt acgtgaacat
     1861 gacgggcgac ggacggtcac ggttatgacg ctcctcacgc acgccaccgc catgaccccc
     1921 tatttccttg cgacttggaa tgaaggctgc aattcggaca gaaagcccag aggtgccgca
     1981 gtcgggggaa atctctcgct ctgcgagcgt gccccggcgt gtgccccgtc gcgcccccgc
     2041 cgagcgcctg tggacaaccc gttgccccag gaatccatgt cgtatcgtcg aaaggcacat
     2101 cccgtcggcc tgagccgcgc cggcgggagc cgagagggag gagcccttcg tgacgcagca
     2161 ggtgccgtcg accgaacccg agctggccgg agtgcgcaac ttccgcgacg tgggcggact
     2221 gcccacggtc gacggacggc gggtgcggca cggcgtgctg ttccgcagcg gtcacctcgc
     2281 gcacgccacg caggaggacg ccgccttcct gtcctccctc ggcctgcaca cgatcttcga
     2341 cttccgcaac gcggccgacc agaagctgga gggcccggac gtcgccctgc ccggcgtgcg
     2401 gaacgtgaac ctgccgctga gcgacccggc cgacggcgcc gagttctgga agatggtccg
     2461 tgacggcgac atcgagcagc tgcgcggaat cctcggcgac ggcagggccg cggcccggat
     2521 gatcgcctcc taccggcaga tcatcaagga gcgcaccgcc gagcactccc gggtgctgca
     2581 cgcgctcgcc gaggacagcg tcccggccct gatgcactgc gcggcgggca aggaccgcgc
     2641 gggcctctcc atagccgtca cgctcctcgc cctcggggtg gagcgggagg cgatcatcgc
     2701 cgactacctg gagtccaacg ccaagcaccg ccgctacaag gtgcaccgca gcaacggctc
     2761 gggcgacgcg tactcccccg aggtcatgga gctgctcagc cccctgttcg acgcgcgcgc
     2821 cgagtacctg acggccgcct tcgagacgat cgagcagacc tggggcgacg tcgacaccta
     2881 tctggagcag ggcctcggcc tggcgcccgc gacccgcgag cggctgcgcg agcgcctgct
     2941 ggactgaccg ctccggcggg ccgtcgtacg gctactggtt ggcgcccacc tcgaacagca
     3001 gccagatgaa cgcggccagc acatggccca ccgcgatgta gatgatcagc cggatccaca
     3061 gggtgcgcgg aaacctctcc tcgcggtcgt tcatgacgtc tctccagggg tgtggccgag
     3121 gcacagcgtg gccgtcgggc tctgcagcag cgtgtggacg aagagcagct ccgccccgcc
     3181 ctcgtcctgg gcggcgatac ggtgcggggt cagcgagtcg aagtgcgcgc tgtccccggg
     3241 ggcgaggcgg tgcgtggtgt cgcccaggcg cagcacgagc cggccggcga ggacgtacag
     3301 ccactcctca ccggggtgga cgcgcacgat gtcgccctgc gagccgtagg ggacgcggac
     3361 gcgcagggcc tgcatgcccc ggcccggcgc gcccgcctgc cagtacgtcc agccgcccgc
     3421 cgccgtcggc tccatgtcgg cgtggcgcac gacggcgtcc cgctcggcga ccgtctcgcc
     3481 gagcagctcg gagaccgtcg taccgtagat acgggcgagc gcgagcagca tcggcaggga
     3541 gggctggcgc tgcccggtct ccaggcggga caggtgggcg ggcgacagtc ccgcggcgcg
     3601 ggccgccgcc tccagggtga gaccggcccg gcggcgcagg gcgcgcagct ggggcgccac
     3661 ggtcggcagg ccttcggggg ccggcccgtc gggcgggccg tcggaggagc tcatgcctcc
     3721 attgagccga agttttgcct ctgcggcaat tttcttgcct cagaggcaaa agctcgtcag
     3781 cggttggcca ccgcctgctt caccagcgtc ttgccgaagt cccacatcag cccgccgccg
     3841 ctgtgcgcgt cgtccatcac ggcggtgaag gcgtcgacga accggtccac gtccgcctcg
     3901 tcgatcacca gcggcgggat cagcttgatc acctccaggt ggtcgccgga gacctgggtg
     3961 aggatccggt gccgctggag caggggcacg accaccatct gcgcgaacag acccttgcgg
     4021 gcggcctgga gcatggtcca gcggctgcgc agtttcagcg acttcggttt cccgaactcg
     4081 atgccgatca tcaggccccg gccgcgcacg tcggccagca gctcgtactt gccgatcagg
     4141 gcggtgagcc gggacttcag cagctccccc atggcccggg cgttcgccac ggtctgctcg
     4201 ttctccatga cggacagcac cgcgagcccg gcggccatgg cctgcgcgtt ggacccgaag
     4261 ctcgccgagt ggaccagcac gcggtccatc gacgagtaca ccttcttgaa gatccagtcc
     4321 ttgccgaggg tggcgccgac cggcacatag ccgccggaga gcgccttggc gacgcacacc
     4381 aggtccggct cgacgccgtc ctcgtgctgg taggcgtaga agtcgccggt gcggccgagg
     4441 ccggtctgca cctcgtcggc gatgagcagc gccttgtgcc ggtgcagcag ctcctgcgcg
     4501 gcccgcagat agccgggcgg ggcctcgtgg acgcccttgc cctggatcgg ctcgacgatc
     4561 agcgcggcga catcgccctt gcgcagctcc cgggcgagcg cgtccaggtc gccgagcggg
     4621 acggcggtgt ccggcagcag cggggcgaag ccgtcccgga agccggactc gccgttgacc
     4681 gacagggagc cggtggtcag gccgtggaag gcgtgctcgc agtacaggac gcgcggcttg
     4741 ccggtggcgt accgggcgaa cttcagcgcg ccctcgaccg cctcggtgcc gctgttgccg
     4801 aagaacaccc ggtccaggtg cgggctgtgc gcgagcagct tctccgcgag caggccgggc
     4861 agcggctggc agtcgaaccg ggtgaggtcg gccaggttca ggtccagcac gtcgtgcagc
     4921 gcctggcgga ccacggggtg gtggcggccc aggcccatca ccccgaatcc ggcgagcatg
     4981 tccaggtagt cgttgccgtc cgcgtcccag aagtgggcgc cctcggcccg ctcgtagacc
     5041 ttgtcgaagc cgatggtgtg cagcatgcgc gggagctggt ggttgaggta cttgccgtgc
     5101 agctcgtagc gctcggcccc gcgtgcggcc agcagggcgg cgaggtcgaa cccaccggcc
     5161 tgcgagggcg acggcgacgc ggatttggcg gttgtcatgc ctgtttctcc ttggacggct
     5221 cttcctcggc ggccgggccg gtgccctcgg cgtgcgcacc gatgtccttg acggccaggc
     5281 tcgcgctgat ccggcccgcg acctcgacgg gcgtcagccc gatgtcggcc agcacctcgc
     5341 cgcgcttggc gtgcgcgagg aactgctccg ggatgccgaa ccgccgtacg gggacgtcca
     5401 cgtcggcgtc gccgagtgcc agcgccaccg cgctgccgac gccggccgag cggctgttgt
     5461 cctccacgac ggcgaccagc cggtgccggg cggcgaggcc gggcagcgcc gggtcgaccg
     5521 gcttgaccca ccgggggtcc acgaccgtgc agccgatgcc gcgcgcttcg agcagctccg
     5581 ccgcctggag gcagacgggc gccatcacgc cgaccgcgac cagcagcacc tccggccgct
     5641 cggcgcggtg caggacgtcc agtccgccca cccggtcgac cgccgggatg ctcggcccgg
     5701 ccgactcctt cgggaagcgg accagtgtcg gcgcgtcgtc cacggcgacg gcctcccgca
     5761 gctgggcgcg cagctggtcg gcgtcgcgcg gcgcggcgat cctgaggccg ggcacgacct
     5821 ggaggatgga catgtcccac atgccgttgt gcgagggccc gtcgacgccg gtgaccccgg
     5881 cccggtccag tacgaaggtg accccgcagc ggtgcagggc gacgtccatg agcagctggt
     5941 cgaaggcgcg gttgaggaag gtggcgtaga cggcgacgac cgggtgcagc ccgccggtgg
     6001 ccaggccggc cgcggagaca accgcgtgct gctcggcgat gcccacgtcc cacacccggt
     6061 cggggaagcg ggcggcgaac gtgcccaggc cgacggggtg cagcatggcc gcggtgatcg
     6121 ccacgacgtc gtcgcgctcc tcgccgatgc ggaccatctc ctcgccgaac accgacgtcc
     6181 aggacggccc gcccgcgggg acgagcggct cgcaggtgag cgggtccatc acgccgacgg
     6241 tgtggaagtg gtcctcctca tgggcgaggg cgggctcgta gccgcggccc ttctccgtga
     6301 ggcagtgcac gaggaccggc ccgtggaagc gcttggctcg ccgcagcgcc gactcgaccg
     6361 ccttgatgtc gtgcccgtcg atcgggccga cgtacttcag gcccaggtcc tcgaagaggc
     6421 cctgcggggc gaaggcgtcc ttgaagccct tcttggcgcc gtgcagggcc tcgtagacgg
     6481 tgccgccgac gaccggggtg cgctgcagga cctccttgcc ccaggcgagg accttctcgt
     6541 agccgtcggt ggtgcgcagg gtcgccaggt ggttggcgag gccgccgatg gtcggcgcgt
     6601 acgaccgctc gttgtcgttg acgacgatga tcagcggccg gtccttggcg gccgcgatgt
     6661 tgttcagcgc ctcccaggcc atgccgccgg tgagcgcgcc gtccccgatg acggcgacga
     6721 cgtgcccctt cccgccctgc acctggcgtg ccttggcgag gccgtccgcc cagccgaggg
     6781 cggtggaggc gtggctgttc tcgatgacgt cgtgctcgga ctcctcgcgc gagggatagc
     6841 cggacagacc gcccttgccg cgcagcttgg agaagtcctg acgtcccgtc agaagcttgt
     6901 ggacatagct ctggtgtccg gtgtcccaca ggatgcggtc gaccggcgac tcgaagaccc
     6961 ggtgcagggc gacggtgagc tccaccacgc ccaggttggg gccgaggtga ccgccggtcc
     7021 tggcgaccgc gtgcaccagg aactcccgta tctcctcggt cagttcaccg agttccgcct
     7081 cggacagcgc cttcaggtcg cgtggtcccc ggatgttctc cagaatggtc acgctcgggc
     7141 cccctctcgg tccgtgccgt acgtcagctc accgtcactg ccggtttccc cgggtccggg
     7201 gcggtgccct cccgttccat ccgctcggcg atcttcatcg cctcctcgat cagcgtctcg
     7261 acgatcttcg actcggggac cgtcttgacg acctcgccct tgacgaagat ctggcccttg
     7321 ccgttgccgg aggcgacgcc gaggtcggcc tcgcgggcct cgccggggcc gttgacgacg
     7381 cagcccatga cggcgacccg cagcggcacc tccatgccct ccaggcccgc cgtgacctcg
     7441 tccgccagct tgtacacgtc gacctgggcg cgcccgcagg acgggcagga gacgatctcc
     7501 agccgccgct gccgcagccc cagcgactgg aggatctgga tgccgacctt gacctcctcg
     7561 acgggaggcg cggacaggga cacccggatc gtgtcgccga tgccctggga gagcagcgcg
     7621 ccgaaggcca ccgcggactt gatcgtgccc tggaaggccg ggcccgcctc ggtcacgccg
     7681 aggtggaggg ggtagtcgca ctgggcggcg agctggcggt aggcctcgat catcacgacg
     7741 gggtcgttgt gcttgaccga gatcttgatg tcgcggaagt cgtgctcctc gaagagggat
     7801 gcctcccaca gcgccgactc gaccagcgcc tccggggtcg ccttgccgta cttctccagc
     7861 agccgcttgt cgagcgaacc ggcgttgacg ccgatccgga tcggcgtgcc gtggtccttc
     7921 gcggcccgcg cgatctcgcg cacctggtcg tcgaacttct tgatgttccc cgggttcacc
     7981 cgcaccgccg cgcagccggc ctcgatggcg gcgaagacgt acttcggctg gaagtggatg
     8041 tcggcgatga ccgggatctg cgacttccgg gcgatcgtcg cgagggcgtc cgcgtcgtcc
     8101 tgcgtcggac aggcgacgcg gacgatctgg cagccggacg cggtgagttc ggcgatctgc
     8161 tggagcgtgg cgccgatgtc cgacgtacgg gtcgtcgtca tggactgcac cgacaccggc
     8221 gccccgcccc cgaccgccac cggcccgacc tggatccgcc gcgacacccg ccgctcggcg
     8281 accggccgga ccggtacctc gggaacgccc agggaaatgg cggtcatgac gtcactcccg
     8341 gtttccggag accgtctcgc gcatcgcccg cagggactcc ttcagcgagc ccatggtggc
     8401 gaggacggcg gtgggctcgt agccgcagtg cgccatgcag ttggcgcagc gcgggtcctt
     8461 gccccggccg tacttgtccc agtcggtctc ctcgatgagt tcgcggtacg tcggcacgta
     8521 gccgtcgctc atcaggtagc agggccgctg ccagccgaag agggagtagt tggggatcgc
     8581 ccacgcggtg cacgggaagt ccaccttgcc ctccaggaag tccaggaaga gcggggagtg
     8641 gttgagccgc cacttgcgcc ggttgccgcc cgcgaaggcc ttcttgaaca gctcgcgggt
     8701 ctgctccacg cccaggaagt gctcctggtc gggcgccttc tcgtaggcgt aggcgggcga
     8761 gatcatcatc tcgtcgacct tgaggtcgtc gttgaggaag ttcaggacct cgatgatggt
     8821 ctgcggggtg tcggtgttga agaaggtgga gttggtggtc acccggaagc cgcgccgctt
     8881 ggcctccttg atggcctcga ccgcctcgtc gaacacgccc tccttcgcga cggactcgtc
     8941 gtgccgctca cgcagcccgt cgatgtgcac ggcgaaggcg aaatagggag agggcttgaa
     9001 cttgtcgatc ttcttgcgca gcagcatggc gttggtgcac aggaagacgt acttcttctt
     9061 ggccaccagc tggcgcacga tctcgtcgat ctgggggtgc atcagcggct caccgccggc
     9121 gatggacacc atcggcgcgc ccgactccag cacggcaccc acggcctgcg cgaccggcat
     9181 gcgctgcttc agcacacccg ccgggtgctg gatcttgccg cagccctcgc acttgagatt
     9241 gcaggcgaac agcggttcaa gctccacgat cagcgggaac ttgtcccgct tgcgcagttt
     9301 ctgttcggcc aggtatgtag cgaccttgat ggactggcgc agcggcatgg ccatcgggct
     9361 tacctcctcg ggagcagcac attgcggtgc cattcgtaaa aagcaggtag tacggaacga
     9421 agaacgcgga aagccgatat tccaccgcgc accgtgccga tccggacgag ttcatgttct
     9481 ggagcgtcca cgaccacccg gacggccgca accgggcgct cgcccgagcg cacggcgctc
     9541 aggagcgtgg ccgccgactc catgtcgacg gcgatcgcgc cggtcgcgcg cagcgcggag
     9601 cgctccgggc cgcggaccac atggtccgag ccggtgagcg ggccggtgtg gaccgtgcgc
     9661 ccgggcagga tccgggcgag ttccttgacg agcagttcgg tgccgacgca ggccaccgtg
     9721 gaccgcgggt cccgggtctc ctcggcgacg accaggtcgc cggggtgcat gccgggcgcg
     9781 agtcccgcgc agaagccggt ggcgagcacg gcggcgtcgg cgaacgcggg gtcggccagc
     9841 agccgggcga ccgacctctc ggccgccctc ggacccatgc cggtgcgcag cacggtgacc
     9901 ggcccgcccg tctcaccgcg atcgcgccgg cgcagggcga ggtgctcgat gccgagcgcg
     9961 caggcgatca gcagcggggc cggggcgggc tgggtgctca tcacatcccc ttggcctcgg
    10021 cccggggccg gtccgcggcg cgggcgccgg gtgccggaag ccggccggcg aaggggtcgc
    10081 cgttgaggta ccggccgagc gcggtgagcg ggaacacctg ccggtacagg tggtagttga
    10141 tggagaagtc ccacgggaag ccggtgccgg tgaaatacgg ctcgtcccag gagccgtcct
    10201 cgcgctgggt ggcggccagc cacgcgacgc cgcgctcgac ggccttggac tccttctccc
    10261 ccgccgccag cagcgccatc agcgcccacg cggtctgcga ggcggtggag gcgccgcgcc
    10321 cggcccactt gcgggcgtcc ttgtaggagc gcaggtcctc gccccagccg ccgtcgtcgt
    10381 tctgcacgga ctccagccag gccaccgcgc gccggaccgc cgggtgcgag gcggggatcc
    10441 cggcggccac cagggcgggt acgacggatc cggtgccgta gatgtagttg acgccccagc
    10501 gtccgaacca cgagccgtcc ggctcctgtt cggcgagcag ccactcgatg ccgcgccggg
    10561 tgcgcgggtc gtgtgcgagg ccctccacgg cgagcatctc caccacgtgc gcggtgacgt
    10621 ccgccgacgg cgggtcgatg acctcaccga agtcgcagaa cggcagccgg ttggggaagg
    10681 ggctggtgtt gtcgacgtcg aaggcgcccc acgcgccgtt cttcgactgc atgccgaggt
    10741 tccagcgcac cccgcgcgcg atggccccct cgacccggtc ggggtcgtgg tgccggaccc
    10801 tgcgcagcgc gaggaccacc tcggcggtgt cgtcgatgtc gggatagttg tcgttgtgga
    10861 actcgaacgc ccagccgccg ggcggcagtc cggggcggcg tacggcccag tcgccggggc
    10921 ggacgatctc ctcgccgagc atccagtccg cggccttcac cagctgcgga tggtcggtcg
    10981 gcagtcccgc gtcgacgagg gcgatggtgg ccaggcaggt gtcccacacc ggcgactggc
    11041 aggcctcgat catgcgggcg ccgtcctcgc gccacacggc gaaccgttcc agcgaggcga
    11101 gcccctcgcg gatcaccggg tgctggaggt cgtagccgag caggtgcagc gcgatgatcg
    11161 agtacacggc cgggggctgg atgccgcccc agcagccgtc gttctcctgc cgttcgatga
    11221 tccagcgggc ggcggtgttc atcgcggccc tgcgcagccg cttcggggcg accttgcgca
    11281 gcgcgtgcag cgccttgtcc aggcgctgga aggcgccgtc ccaactggcc accggggcaa
    11341 ggggcttgac cgggttgggg tgggcggggt cggtgtgcag ctcgtccagc gggaagggtg
    11401 ccgggcgcac cgggcgcttg gcggagacga tggtcagcgg cacgatcgtc tgccgggccc
    11461 agcagccgaa gtcgtagatg ttgagcggga cccaggtggg gaagaagatc agctcgggcg
    11521 ggagttcggg caggtcctcc cacttccacc agccgaacag cgcgagccag atccgggtga
    11581 agacccgggc ggcggcgatg ccgccctgcg cgcggatcca cgcggaggcc ttcgccatgt
    11641 gcggcgcgtc cggcgcgtca ccggccagcc gcagggcgac gtacgcctcg atggtggcgg
    11701 acagctcgcc cggcccgccg tagaaggtgg cccaggtgcc gtcctcgcgc tgctcgccgc
    11761 ggatgaacag cgcggcggcc tgggcggtgg cctcgtcgag gatgcccagg aactggcgga
    11821 gcagcaggtc ctcggcgtcc atggtgacgt tggtctcgag gtcgcccttc caccagccct
    11881 cggcgtcctg ccgcgccagc aggaagtcgg tggcacgcgc caccgcgcgc cgggcggcgt
    11941 ccggtacatc cggtaccccg gccgccgcgg ggatgtcggt gcgggtttcg ctggccgcgg
    12001 cagcgcgggg cggcagtgcc ccggtgcttc cgtcggtcgt cgctgtcatg gcttcccctt
    12061 cgtgcagtcg tgcaagtcgt gctgctgtgg gtccgccgtc ggccggtgcc gtgtctgccg
    12121 cggcaccggc cggcgactac gcgtcgggtg ttcgaccgat agtgatcatc tcttccgtac
    12181 gacgacgaag tccgcgagcg ccgtgaaccg cgcccggacc tgctcgggca tgtcgacggc
    12241 gtcgagggct tcgatggcga tggtgtgctg gcggcgcgcc tcctcggcgg tccagtcccg
    12301 gccgccggcc tcctcgatga ggcgggcgcg ggccgcgaac tcctcctcgg agaagttctc
    12361 gaagtcgctg ctcttggcgt cggcggcgag cagctcgccg agtcgcgcgg cagcggggcc
    12421 ctcggcggcg agcgcggcga cgaccggcag ggacttcttg cgctggcgca ggtcgctcca
    12481 ggtctgcttg ccggtggcct ccgggtcgcc ccagatgccg agcaggtcgt cgacggcctg
    12541 gaaggcgagg ccgaggtggt agccgtactt ctccagcgcg tcggcggtgg cgtcgtccgc
    12601 gccgccgagc accgcgccga tggaggaggc gcaggcgagc agggcgccgg tcttgttgcc
    12661 ctccatctcc aggcactcat cgacgctgac gcggtcgcgg tgctcgtagg agatgtcctg
    12721 ggcctggccg tcgatcagcg cgcgggtggc ggtggtcagc cggcgggcgg cgcggccggc
    12781 ctccacggtg cccagctcca gcagcacctc gttggcgagg gcgaacaggg cgtcgccgac
    12841 caggatggcc tgggcggggc cgtgcacctt ccagacggtg tcgcggtggc ggcgctgctc
    12901 gtcgccgtcc atcaggtcgt cgtgcagcag cgagaagttg tgcaccagct cgacggcgac
    12961 cgcgccgggc acgccggtct cgggggcggc gccggtgacc tcggcggaca gcacggcgag
    13021 ggcggggcgt acggccttgc cgccgtcgcc ggcggtgggg ttgccctgtg cgtcgatcca
    13081 gccgaagtgg taggcggcaa cggtgtccat gggcggcgcc aggcggtcga cggccgtccg
    13141 cagcaccggc gtggcaagcg tccggccgcg ctccagcagc gcggtcacgt ccaccgcggt
    13201 cctccgagcg gccgtctcgg ccgggggcac agtgggcaca gtctctcctc ttgttgcggt
    13261 accgggggtg cgggagcctg ccgcgccgcg ctcgccgatc atcacgccgc ctcctcgaac
    13321 gcgaagagat ggcgggggcg gggccggccc agggcgccga gcgcggcctc cgccgcgctc
    13381 acaccgctgc ggaccgcact ctccatggtc gcgggccacc cggtggcggt ccacgctccg
    13441 gccaggtaca ggccgggggc cttggtgcgg gcgccgggcc gcagccgccc gacgccgggg
    13501 gtgggagcga acgtggcggt gcgctcccgg gtcacgaaga agtccagcac ctcggcgtgc
    13561 cgggtgtgcg gcagcagccg cccgagttcc gggaggtagc gctcgcgcag ctcggcgacc
    13621 ggccggtcga tgtcgtcctg cgccgccgac tgggacagcg ccaggtactg gccgccgccg
    13681 ctcagcccgg aggcctcggt gcggtcgaac acccactgca cgggcgtgcc gagggcggcg
    13741 aagaaggggg cgtggaggac gggacggtcg tagacgacgt gcacgttgag gatcggcgcg
    13801 gtgccgatgt ccagcagccg ctcgggggcg tcgagcgcgc cgggcggcag caggtcgtac
    13861 gtctcgcgct ggggtacggc gagcacgacg gcgtcggcgg tgagcgtgtc gccgggaacc
    13921 tgaacgctcc aacgcccgtt ctcgtcaata gagatggagg tgacgcgtgt acggagtccg
    13981 atgcgcacgc ccgcggtctc gagcgccttg cgggccagcc ggtcgtgcag atcgcccagg
    14041 gggacgctcg cccagccgat gtcggcggca cccgggtcgg acagcagacc ggtcttgaac
    14101 accatggcgg cgagccccag cgaggcgtcg ccggcgaccg cgttgagggt ggcgacgccg
    14161 accaggtccc acagggcctc gacggcacgc gccgactggc cgtgcgcggc cagccagctg
    14221 ccgaagtcct ggtcgtccag ggccggatcg gtgaggtcga gccccttgag cgcgagcgcg
    14281 gcgcgcccca ccttggcgcg ctcggcgagc gagaggtgcg ggtaggtggc gaggctgcgt
    14341 cccaggtgca gcgggacggg cagcgcgtcg cgccgcagcc ggccgagccg gcgcccctcg
    14401 ggcttgccgg cgtccacgac gggcacgtcg agacggctct gcagcggagc caggtcggcg
    14461 gcctggatcc ggtcgaggaa ccagcggtag gcggtgcagc agcgcaggta gacgtgctgt
    14521 ccgttgtcga cggtcagtgc gccgcgccgg aaggagaagg cgaggccgcc cagtctcggt
    14581 ctgccctcca gcagggtgac gcggacgccc gcgtcggcga gcgccagggc ggcggtgacg
    14641 ccggcgaggc cgccgccgat caccacggcg tcccggccgg gccgggcggc gtgatgtggt
    14701 ggcccgtcgg accgggtccc gtcggtcatc gcacgccctc ccctgcccgt ccgccgagat
    14761 gggtgaatgc tgtacggcag gccgtcgcag tcagggacgc cgcgccgcac cggagggttg
    14821 cgtgccgcat gccgccttcc gaggtcgagt ccatcaggcg cgcctcctga cggtctgccg
    14881 ggagacgttc cgcgcgtcca ggccggacag gccgcgcacg gcgacgtagg ccttctcgtg
    14941 cccgggcagc gagacccggc cgcgcagcac ggcctccggg tcgcgctcga tgcggtcgag
    15001 caggcggcgg tagatgccgg ccatggcggc gacgcaggcg ccgctgcgcc ggtcgagcat
    15061 gggcagcagg cggtagccct cggcgaaaag agcgcgggcc cgccgcactt cgaagtgcac
    15121 gaggcccgcg aagtcggagc cctgtggtgg ggtcggcccg tcgaacccgg cggagcagcc
    15181 gaacttggcc aggtcgtcgg ccgggaggta ggtgcgtccg ccctgggcgt cctcgcggac
    15241 gtccctcagg atgttggtga gctggagcgc gagcccgagc gtgtcggcgt actccggcgc
    15301 gcgttccgcg ccgcgcgccc ccggttcggt gccgaacacg cccagggaga gccgcccgat
    15361 ggcgcccgcc acgcagcggc agtacacctt caggtcgtcc caggtctcgt aggtctcgcc
    15421 gcgtacgtcc atctggacgc cgtcgatcag ctcgtcgaga ccgccgagcg ggatcgggaa
    15481 gtgctcggcg gcgtgcgcga gggcgaccgc gacggggtcg gtgtcgtcct cctcgacctc
    15541 gcccgcgcgg atacgcgtga gcagcgcccg ggtgtcctcc agccgtgcga ccttgacatc
    15601 gttgctcagc gccccgtcgc cgatgtcgtc gacgcggcgg gagaacgcgt acagggccga
    15661 catcgcgcgc cgcttgtgcg tgggcagcag ccggatgccg taggcgaagt ttcgggcctg
    15721 ctgtccggtg acggcctcgc agtagctgta ggcggcgagt accggtgcgg acgcgggcgg
    15781 tggcagctcc acggtccgga tcacccctct cctcgcagag tcacgcccac ctcacgcagc
    15841 aaccggagct tgccgtgccg gggcgggccg ggaagtacgt cgtagtcggc ggcggcgatc
    15901 gcgccgaggg ccgcccgtcc ccccgccacg aaccctgcga gcagcagttt caacctgccg
    15961 tggacgctac ccaccagggg ggcgccttca ttcagcagat cgcgggcgcg ttgtgcctcg
    16021 tatgcaacca gggcgcgcac cgatgcgccc gcggttttcg ccgcgaggtc cgcctcctgg
    16081 acgtgaaaac gcttcatgtc ggcggcgggg aggtagatac ggtcgcggcc gaggtcctcg
    16141 gccacgtcct ggaggtgctc gacgatctgc agcgcggtgc agacggcgtc ggagcggcgg
    16201 atccgctcgg gggtcgaggt gccggtgacg gcgaggacga ggcggccgac ggggttggcg
    16261 gacagttcgc agtaggcgag gaggtcgtcg aaggtctcgt agcggctgac gagctggtcc
    16321 tgccggttgg cggcgatcag gccgaggaag ggctcggggg tgagcgagca gcggcgcacg
    16381 gtcggctgca ggcggcgcag cagcgggtgc cggggcgtgc cgtcgaagac ccgccacagg
    16441 tcggcctcga aggcgtcgag caggacgagc cggtcctggg cctcgccggg ggctaccccg
    16501 agcaggcggg cgtcggcgcc gccgggcgcc aggtcgccgt cgccgatgtc gtcgacgagg
    16561 cgggcgaagc cgtagacggc catgaggtcg gcgcgccagg cgcggggcag gaagaagggg
    16621 gccacgggga agttctcgtc cgcggccttg gcgagcgtgc cgtgcccggg gtcgcccgcg
    16681 tgcgccggcc gcgcggtccc cactcccgct gtcgttcccg tcaccgcgcg ctgccccggg
    16741 cggggacggc acatgctgcg ttgagctggg gagtttccgt agccattgcc gtcacatctc
    16801 ccgttctaca ctgccgaccc aatacacact atttcggaca cgccgcccgg cggtccgcac
    16861 ggctgcccca agtgagggtg tcgcgcatta tctccccact tgccgccttt ggggaccggt
    16921 acagcttacg ttgtacaacg cagcggggac cgcgggggtg tcctgcacat cacaacaaca
    16981 caccgattgg ctccaagatt ccttacggga gccgtagttg acgtttcttt tgcagacgca
    17041 gggccccgcc ggagcagttc cggcggggcc ctgggccggt cggggtcact tccccgtgaa
    17101 cttctcgtac tccttgagca cctcttccgt gggcccgtcc atgcgcagtt cgccgcgctc
    17161 cagccacagc acacggttgc aggtgtcacg gatggacttg ttgctgtggc tgaccaggaa
    17221 caccgtgccc gcctccttgc gcagctcccg gatgcgctcc tcggagcgct tctggaactt
    17281 cgcgtcaccg gtggcgaggg cctcgtcgat catcaggacg tcgtggtcct tggcggcggc
    17341 gatggagaag cgcagccggg cggccatgcc ggaggagtag gtgcgcatcg gcagggtgat
    17401 gaagtcgccc ttctcgttga tgccggagaa gtcgacgatg tcctggtagc gctccttgat
    17461 ctcctcccgg gacatgccca tggcgagccc gccgaggatc acgttgcgct cgccggtgag
    17521 gtcgttcatc agcgccgcgt tcacgccgag gagcgagggc tggccgtcgg tgtagacctt
    17581 gcccgactcc gggggcagca ggccggcgat ggcgcgcagc agggtggact tgccggagcc
    17641 gttggagccg atcaggccga tggcctcgcc gcggtaggcg acgaaggaga ccccccgcac
    17701 ggcgtgcacc ttgcgcaccc cgcgcgcggc ctcgtcggag ccccgcttca ggatgcggct
    17761 gagggccgcg gtggcgctgc ccttgccgcc cccgccgccg ttgacccggt agacgatgtg
    17821 cacgtcgtcg gcgatgacgg tggggacgcg ggcgtcggtg cgctgctcag ccacggccgt
    17881 acctctcctc ggccttccag aagtacacga agccgccggc cgcgaagagc acggcccagc
    17941 cgaccgccgc cgcccacacg tggggaggca gattggacga gccgtagccg tcgatgaggg
    18001 cgaagcgcat caggtccatg tagatggcgg cggggttcca ctgcagggcg gtggtgaccc
    18061 agtccggctt gtccgccagc atcaccggga tggagaacat cacgccggac gcgtacatcc
    18121 aggtccgcat gacgaacggc atcagctgcg cgaggtcggg ggtcttggcg ccggcccgcg
    18181 ccatgatcag ggcgaggccg gtgttgaaca ggaactgcag cgccagcacc ggcacgatca
    18241 gcagccagga caggtccggg tagctgccga acccggccgc caccagaaac agcacgatca
    18301 tcgagaacag cagctgctgg agctgctgga gggagaagga gaccggcagc gaggcgcgcg
    18361 ggaagtgcag cgcgcgcacc aggccgaggt tgccggagat cgcacggacg cccgccatca
    18421 cggacgactg cgtgaaggtg aagacgaaga cgcccgtgac gaggaacggg atgtacacct
    18481 cgcgggccat cccgcggtcc gccttgagga tcacgccgaa gatgaagaag tacacggccg
    18541 cgttcagcag cggcgtggcc acctgccaga gctggccgag cttggcctgg ctgtactggg
    18601 cggtcagctt cgcctgggag aacgcgagga tgaagtggcg gcgcccccac agctgccgga
    18661 cgtactcgcc gaggccgggc cgggcaccgc tcacggacag cccgtaccgg gcggcgagct
    18721 cggccgccgt gaggccctcg tcgggcgatg cggccccgct cagcgtgacg gggtcgtcat
    18781 gcgttgtctc actcacaagt ggaaactttc gtcttcggat tgcgcggcct gtacgggcgt
    18841 gcggccggga ccgggtcggt ccctccggcc ggagccgtcg ggtcacggcc cgcacgctct
    18901 cacggtcgag cctgtcagat gaccggcggg cggcccagtc tcgtcagccg ccacacggta
    18961 cgccacttca tgggccggcg gggcccgcac ggggtggtcc agccctcccg gaacccgccg
    19021 aaccaggccc tcagcgccgc cacccgcggc cggcgcagca gcgtcagcag cagccagacc
    19081 ccgaggtaga cggggacgag cggggcgggc aggttgcggc gggccagcca gacccggttg
    19141 cgggcgacca tgcggtggta gaccgcgtgc cgcgagggcg cggtcgccgg gtggtacagc
    19201 accatgtcgg accggtagtc gatcatccag cccgcgtcga gggcccgcca tgccaggtcg
    19261 gtttcctcat gggcgtagaa gaattcctcc ggcagcgtcc cgacctgctg gaagaccgcg
    19321 gtgcgtacgg cgttggcgcc gccgaggaag gtggtgaccc gcgaggagcg catcgggtcg
    19381 gcggcgcgca gccgcggcac gtggcggcgc tgggtgacgc cggaggcggg gtcggcgatg
    19441 cggaagctga tgatgccgag ccgcggatcg gccgcgaagg cctgccggca cagctcggcg
    19501 gtgtcggtgc gggcgagcag cccgtcgtcg tcgaggaaca gcaggatgtc gacgtcccgg
    19561 ccgcccgggc cgaacgcctc gatgccggcg ttgcgcccgc ccgggatgcc gaggttctcc
    19621 ggcagctcga tcgtgcgcac cccggcgggc aggtccggca ccggggagcc gttgccgacg
    19681 acgaccacct cgacggggtc gccgtcctgc gcggcgacgg actccagcag cgcccgcagt
    19741 tccccggggc ggttgcccat ggtgatgacg accgcgccga ccttcaccgg aacgctcact
    19801 tcagcctgcg cgaggcgagc acggacacca ggtgcagcac ggtctgcagc atcgcgatgc
    19861 cggccagcac ggcggtgccg aggcgggtga agtacaggtc gccgcggacg tggtcggcga
    19921 tcgcgaggac gaggatcagc agggacgcct cgatgccgag gatcagccgg tggaacttga
    19981 gcgcggcggc ggcccggcgg gccagcgcca tgccggagga gcgcatctcg gcggcgacct
    20041 ccttcaccgg aggcatcccg gcctggtggc gggcgacgcc gaccaggtcg gtctcggcct
    20101 tgatgaggat cgcgccgagc gcggcgagcg tgccgaggaa ggcccacagc cagtcgatgc
    20161 gcccgctgcc gaacaggtcg gcggcgcgca ggccgagccc gaccagcacg gccgcgtcgg
    20221 tcagataggc gccgacccgg tccaggtaga ccccgccgag ggagtactgc ttcttccagc
    20281 gggcgatctc gccgtcgacg cagtcgagca gcaggtacag ctgcaccatg accacgccca
    20341 gcacggcccc ccacacgccc ggcaccagca gcgccggggc ggcgaggacg ccgcacaggg
    20401 tcatcaggta ggtgagctgg ttgggcgtga cccgggtgtt gaccaggtag cggtcgacgc
    20461 gcagggacac ctcgcgcatg tagaggcgtc ccatccagtg ctcgccgctg cgccggtcct
    20521 tcacgcccgc ggggtggacg acgggccgga gttcagctac cgatggcctt gacatagtcg
    20581 gcgtaggtgt ccttgatctg ctcggtcgtg aggtcgaggt gttccaggat ggtgtagcgg
    20641 ccggggcggg tctgcggggc gaactcgacg accttcacga actcctccgc cgagaagccg
    20701 aagtcctccg cgcgcaccgg cagcccgtgc cggcgcagca cctcggtcat gaacaccgac
    20761 tcctccggcg ccccgcgcag ccacatcgcg aaggccgcgc cgaagccgca ctgctcgccg
    20821 tgggcggcgg cccgcttggg gaagagcagg tcgaaggcgt ggttgatctc gtggcaggcc
    20881 ccggaggacg gccgggagtc accggagacc gacatggcga tgccgctgag gaccagcgcc
    20941 tcggcgagca cctgcaggaa gtcgttgtcg ccgatgccgc cggggtggcg gagcaccgcc
    21001 tcgccggcct ggcgggccat cgccgcggcc aaaccgtcga tcttctcgcc gttgacccgg
    21061 ttggccagct cccagtcgcg gatcgcggag atgttggaga tcgcgtcgcc gatgccggcc
    21121 cggacgaagc gcaccggcgc ctcgcggatg acgtcgaggt cgatcaccac ggcgatcggg
    21181 ttgggcacgc cgtaggagcc gcggccggcg tcgttgtcga gggtcgccac cggggagcac
    21241 aggccgtcgt gggccaggtt ggtggggacc gcgaccagcg gcaggccgac ccgcgccgcg
    21301 gcgaacttgg cgcagtcgat gatcttcccg ccgccgaggc cgacgacggc gtcgtagtgg
    21361 ccggccttca tctcgccggc cagccggatc gcgtcgtcga gggtgccgcc gccgacctcg
    21421 taccagtcgg cgccgggcag cgacggcgcg atccgctcgc gcagcctggc tcccgagccg
    21481 ccgctgaccg cgacggcgag cctgccggag tgcgagatcc gctcgtcggc gaggacgttg
    21541 ccgaggtcgt ccagggcgcc ggggcggatg tcgacgacga ccggcgaggg gatgagccgg
    21601 gtcagtagag gcacgcgatc tcccgtccgc gggccaggtc gtcgtggttg tcgatctcga
    21661 cccactggac gtcaccgatg ggggcgacgt cgatgcggaa gccgcggttg accagctcct
    21721 ggtagccgtg ctcgtagaac tgctgggggt cggtctccca cacggtcttc agcgcgtcgg
    21781 ccagctcggc cgcggcgtcg ccctcgatga gcgtgacacc gatgtactcg ccggtcgcct
    21841 cggcggggtc catcagcttg gtgatcttct ggacgccctt ctccgggtcg acgacgacct
    21901 tcatctcctc gtcggcgagg ctcttcaccg tgtcgagggc gaggatgatc ttcttgccgt
    21961 cgccgcgggc ggcgagcagg gtcttctcga cggagaccgg gtggacggtg tcgccgttgg
    22021 cgaggatcac gccgtccttg agggcgtcac ggccgcacca cagggagtag gcgttgttcc
    22081 actcctcggc cttgtcgttg tcgatcaggg tgagcttgag gccgtacttc tgctccaggg
    22141 cctccttgcg ctcgtacacg gcctccttgc ggtagccgac gatgatcgcg acctcggtca
    22201 ggccgatctc ggcgaagttg ccgagggtga ggtcgagcac cgtgatgctg tcctcgttgc
    22261 ctgcgggccc caccggcacc agcgccttgg gcagcgtgtc ggtgtagggg cgcagacgcc
    22321 gtccggcgcc ggccgccagc acgaggccga tcatgcggtt tctccttcgt cgtgtacggc
    22381 gggcgcgcca ccctggtggg cggccaccca gaagcggatg ctctcggcga gcaccagcac
    22441 ggcgacggcc acggcgagtg ccgtgagcgc cacctcgaac tgcggggcgg tgagcagtgc
    22501 ggccaggacg gtgacgagca gcgtccggcc ctcgtgtccc ccggtggccc tgacgagcca
    22561 ggccgggggt gctccggcgt tgccgcggat gcggtacacc gtgtcgtagt gatggtaggc
    22621 gacggccgcc accagcccga aagccgccgg aagcacgccg ttcacccccg atgtcgcggc
    22681 gaggaccagc acggtgccgt actcgccggc gcggaagagc ggcgggacga gccagtccag
    22741 gggcccggtc agcgggcggg agacggcctc ggcggcgcac agcgtgtaca ggccggcgag
    22801 caggacgacc caccagctcg ggccccagga ccaggcggcg agcacgacgg cggcggcgcc
    22861 gagggcggcg gcgagcgggg cgacgcgggg gccggtcgcc ggcaccaggc ggacgagcag
    22921 ctgcacgacc ggaccgtcgt ccgcgaggtc ggccagcgcc tgcgccgccc ggtcggtgcg
    22981 gcgggccttg cgggtgacgg agcgcaggac gcggccggcg gtggtgtaga gggtggcgaa
    23041 ggccatccag gcgaggagcg cgcagaaggt gacgcgcggg gtggtgagcg cggtcagcag
    23101 ggcgatcatg gcccagcgct cgccgatggg caggatgatc acgcgccgga cccacacgct
    23161 ccagccgacg ccgtcgagcc gttcggacag ggcggcggtg ggggccgcgg cggaggtggc
    23221 gtcggcgtcc tgctgggcct cgatgaaggc gaagtccacc atgtgccggg tggtctgcag
    23281 gaccatcgcg gcgagcgcga gcgcccatac gtcgtcggtg ccgccgtggg tggcgccgag
    23341 cgcgaggccg gcgtagaagg cgaactcctt ggcccggtcg aaggtggcgt ccagccaggc
    23401 gccgagcgtg gagtactgca gggagtagcg ggcgagctgg ccgtcggtgc agtccagcac
    23461 gaaggaggcg atgagcagca cgccggccgc gacgaagccg ccgcgggcgc ctgtggcggc
    23521 gcagccggcc gcgatcagcg cggtgagcag cgaggcggtg gtgacctggt tgggggtcag
    23581 gccgcgccgg gcgcaccagc gggcgatgta gcgcgagtag gggctgatgc agtacgtggt
    23641 gaacaggccg tcgccggact tcacggccga cttcaggcgt acggcctcct cgtcgacggc
    23701 ggcgacggcc tgccgtgcct cgttgcgggc ctgcgggtcg gcgggcacgg cggcgaccag
    23761 gctgccgagg gcggggcggt gcacgtcggc gccgtccgcg tcgagcgcgg cggtgatgcg
    23821 gtcggcgagg ccgtccacga cgaccgcggt gccgtccccg gcgccgggga cggcgtccgt
    23881 gccggtcgcg gagtgctcac gggccatggc gcgggtgagg gcctggcggc cggccgcgcg
    23941 cgccgagacg gcgcccggta tcgcggcgag cgcgaagcgc gggtcggtca gggccagccg
    24001 cagggcgtgc acatggccga cgaagcgggc gtcgacgacg gcgacccggt cctcctcggg
    24061 gacccgggcg agcagcgtct ccgcgtgggc ggcgtcggtg gcggggcgta cctcgaaccc
    24121 cagcgcccgc agatcgccct cgatcgacga gccggggacc ggctgaccgg tgaggatggc
    24181 ggtcggcaac cgaactcact tccctgggtg ccggcgcgct gcgccggtgc tgagcatggt
    24241 ggggacgccc ctgggcttgc cagccgggcg gcatgtccgg cagaggctat ccgatacggg
    24301 atgagcggtg ttcaccgccc gttcacgggc cgctccccgc cggatccgcg ccggttccgt
    24361 gcggctcgcg gggcctgtgc cgagatcatc atcggcgatg ggccgcgcgc ccgacaaacc
    24421 gtgcacgcat acccggcatt cgggacatcg gggcgctctg acctgcggaa gcccgcagat
    24481 cgcggccggc gatgcgtttc tgcaggtcag agcagatgac aacggtgttc agtaccgcgt
    24541 tgccggatac cccccacccg tagttcactg ggggttccgg acggccggcg gaagggcggg
    24601 ttcatggggg ctgggcacga tcacgggcat acgcacgcgg cgccggcggg cggcaccgcc
    24661 gccgcggcgt accgcggccg gctgcgggtg gcgctgggga tcacggtcac cgtcatggtg
    24721 gtcgagatcg tcggcgggct cgtcgccgac tcgctcgcgc tgatcgccga cgcggcccac
    24781 atggcgaccg acgccgtcgg gctgggcatg gcactgctgg ccatccactt cgcgagccgc
    24841 ccggccggcg ccaaccgcac cttcgggtac gcccgcgcgg agatcctcgc cgccctcgcc
    24901 aactgtctgc tgctgctcgg ggtcggcggc tacgtcctgt acgaggcggt gcagcggttc
    24961 ctcacgcccg cggggaccga gggctccctg atggtcgtct tcggcgcgat cggcctggcg
    25021 gcgaacacgc tgtcgctgac gctgctgatg cgcgggcagt cggagagcct gaacgtgcgg
    25081 gcggcgttcc tggaggtggc ggcggacgcg ctggggtcgc tggcggtgat cgtctcggcc
    25141 gcggtgatcc tggccaccgg ctggcaggcg gccgacccga tcgcctcgct ggtcatcggc
    25201 gtgatgatcg tgccgcggac gctgaagctg ctgcgcgaga cgctcgacgt gctgctggag
    25261 gcggcgccca agggggtcga catggacgag gtgcgggccc acatcgtcgc cctggacggg
    25321 gtggaggacg tccacgacct gcacgcctgg acgatcacct ccggcatgcc ggtgctgtcg
    25381 gcgcacgtgg tggtgcgctc ggacgtcctg aacgcgatag ggcacgagaa gatgctgcac
    25441 gagctgcagg agtgcctcgg cggtcacttc gacgtggagc actgcacctt ccagctggag
    25501 ccggtcgggc acgcggagca cgaggcgcgg ctctgccact gacgcccgca ctcccgtact
    25561 ggcgttcagg cggttcccgg accgcggcac cgggaatgat cacctatcgg gccccgcttc
    25621 cggacgccgt ggcgtgccgg gagtgcctga ggtgtacggc agactggggg cgcgaggacc
    25681 gatgcgaagg atgggtatgc cgatcactcc tgccaccgcg gcgcacagtt cgtcggcgaa
    25741 cggcaccgcg gatgcgattt tgctcgaact ggtcgacgag aacggcgtga cgatcggcac
    25801 ggcggagaag ctcaccgccc atcagccgcc cgggcagctg caccgggcgt tctcggtgtt
    25861 cctcttcgac gaccgggggc ggctgctgct ccagcagcgg gcgctgggca agtaccactc
    25921 ccccggcgtg tggtccaaca cctgctgcgg ccacccctac ccgggtgagg cgccgttcgc
    25981 ggcggcggcc cggcgcacct tcgaggagct gggggtctcc ccgtcgctcc tcgcggaggc
    26041 gggcaccgtg cgctacaacc acccggatcc ggcctcgggc ctggtggagc aggagttcaa
    26101 ccacctgttc gtgggcctgg tgcagacccc gccgcggccg gacccggagg aggtcggggc
    26161 gaccgccttc gtgaccgccg ccgagctggc ggagcggcat gcgcgcgacc cgttctcggc
    26221 gtggttcatg acggtgctgg acgcggcccg tcccgcgatc agggagctga cgggcccgtc
    26281 ggccggctgg tgagccgtcg gctccctttc ctccacggaa gccgtacggc ggttctaacg
    26341 cagtgcggcg ggtttgagcg gcagggcggc ccagatcacc ttgccgccgc tcgccgtgtg
    26401 ctcgacgtcg cagacgccgc ccgcctccct ggtgatctcg cggacgagga gcagtccgcg
    26461 gccgccgacc tgtgcgtggt cggcctccag ggcggtcggg cggtaggggt ggttgtcctc
    26521 gacggacacc cgcacccact cggcgccgac ggccacctcg acggcgagca tcggggacag
    26581 cagggcggcg tgtttgaccg cgttggtcac cagttccgac acgatcagca gcagcccctg
    26641 caccaggtcg tcggaggcgg gcacgccctg gcggtacagc aggtcgcgca cggcgtgccg
    26701 cgcctgcggg acggaggagt cggcggcggg agcggtgaac cgccacaccc cttc
//
